CN102805824B

CN102805824B - Drug for curing apoplexy and preparation method thereof

Info

Publication number: CN102805824B
Application number: CN201210304734XA
Authority: CN
Inventors: 兰恒志
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-25
Filing date: 2012-08-25
Publication date: 2013-10-30
Anticipated expiration: 2032-08-25
Also published as: CN102805824A

Abstract

The invention discloses a drug for curing apoplexy and a preparation method thereof. The drug is mainly prepared by adopting drugs of salvia miltiorrhiza, liquorice, kudzuvine roots, carthamus tinctorius, caulis spatholobi, raw rhubarb, radix paeoniae rubra, bungarus parvus, gastrodia elata, fructus crataegi, and the like according to a certain weight ratio. The drug disclosed by the invention achieves the effects of calming the liver, suppressing yang, promoting blood circulation promotion to remove meridian obstruction, eliminating phlegm, calming wind, unbosoming depression and inducing resuscitation, is used for curing the apoplexy and has the advantages of quick effectiveness, short treatment course, no relapse and high cure rate.

Description

A kind of medicine for the treatment of apoplexy and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of apoplexy and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Apoplexy is that Chinese medicine is to the general designation of acute cerebrovascular disease.Hurried because falling ill, disease is seen multiterminal, and change of illness state is rapid, and is similar to the benefaction number change characteristics of wind, therefore named apoplexy, apoplexy.It is suddenly to faint, syncope, the distortion of commissure that occurs together, dysphonia and the class disease that hemiplegia is cardinal symptom occurs.Because the primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as its same coronary heart disease, cancer one of three large diseases that threaten human health.At present, because Western medicine can't effectively be treated apoplexy, and has certain side effect, therefore, there is great demand in people to the Chinese medicine of effective treatment apoplexy.

Summary of the invention

The inventor has finally found the medicine of effective treatment apoplexy, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

Purpose of the present invention just provides a kind of composition of medicine that can treat apoplexy.

Another object of the present invention has just provided the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Radix Puerariae, Flos Carthami, Arisaema Cum Bile, Concretio Silicea Bambusae, Radix Notoginseng, the Radix Astragali, Caulis Spatholobi, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Bungarus Parvus, Semen Persicae, Rhizoma Gastrodiae, Fructus Crataegi, Concha Haliotidis, Fructus Evodiae medicine to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby can effectively treat the recurrence of apoplexy.Wherein select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor enters the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, evacuation of pus, the function of pain relieving is controlled angina cordis, menoxenia, and dysmenorrhea, to close, metrorrhagia leukorrhagia mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select Radix Puerariae to be because the sweet suffering of its nature and flavor is flat, enter spleen, stomach warp, the yang invigorating expelling pathogenic factors from muscles is arranged, rash antidiarrheal, the function that relieving restlessness is quenched the thirst, it is cold to cure the wound, warm, headache, stiffness of the nape, dysphoria with smothery sensation disappears and drinks, and has loose bowels, and dysentery, abnormal pigmentary deposit on the skin are examined not saturating, hypertension, angina pectoris, deafness.Select Flos Carthami to be because its nature and flavor are hot, temperature enters the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Arisaema Cum Bile to be because its nature and flavor are bitter, cool in nature, enter the heart, liver, lung three warps, clearing away fire and eliminating phlegm is arranged, the relieving convulsion Epilepsy of Dinging, phlegm-fire is breathed heavily and is coughed, phlegm-accumulating vertigo.Select Concretio Silicea Bambusae to be because its nature and flavor are sweet, GUIXIN, Liver Channel have clear heat and eliminate phlegm, and the function of cool heart arresting convulsion is controlled the calentura coma, middle wind-phlegm fan, and the hot infantile convulsion of children's's expectorant is twitched night cry.Selecting Radix Notoginseng is that temperature enters liver, stomach, large intestine channel, and hemostasis is arranged because of its property sweet and slightly bitter taste, dissipating blood stasis, and detumescence, the function of analgesic therapy is controlled haematemesis, hemoptysis, epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, retention of lochia falls and pounces on blood stasis, traumatic hemorrhage, carbuncle pain.Select the Radix Astragali to be because its nature and flavor are sweet, tepor enters lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting is controlled spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature enters the heart, spleen two warps, have invigorate blood circulation, the function of Shujin, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Radix Et Rhizoma Rhei to be because its nature and flavor are bitter, cold, enter stomach, large intestine, liver footpath, the poison of purging heat is arranged, removing mass stagnates, the function of clots absorbing blood is controlled the excess-heat constipation, and delirium is gone mad, the food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood epistaxis, YANG jaundice, edema, stranguria with turbid discharge, it is red to urinate, the carbuncle and ulcer toxic swelling, furuncle, burn.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, clearing away heat and cooling blood is arranged, the function of eliminating stasis to stop pain is controlled warm poison and is gone mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Bungarus Parvus to be because its nature and flavor are sweet, salty, temperature, poisonous, return Liver Channel, dispel the wind, collateral dredging, relieving convulsion, the function of counteracting toxic substances is controlled hemiplegia, numb limbs and tense tendons, tic spasm, tetanus, joint aches, rheumatoid arthritis stubborn, leprosy.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Rhizoma Gastrodiae to be because its nature and flavor are sweet, flat, enter Liver Channel, endogenous wind stopping is arranged, the function of arresting convulsion is controlled dizzy pupil, wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia, Xiao Jing Epilepsy wind symptom.Select Fructus Crataegi to be because its nature and flavor acid is sweet, tepor enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function is controlled meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's's breast food is stagnated.Select Concha Haliotidis to be because its nature and flavor are salty, flat, enter liver, kidney channel, suppressing the hyperactive liver and subsiding YANG is arranged, heat extraction, the function that makes eye bright is controlled wind-yang and up-boring, and it is dizzy to have a headache, and shies and jerks hectic fever due to YIN-deficiency consumptive fever, optic atrophy.

The specific embodiment

The consumption of medicine of the present invention also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Radix Salviae Miltiorrhizae 15-25 gram Radix Glycyrrhizae 5-15 gram Radix Puerariae 25-35 gram

Flos Carthami 10-20 gram Arisaema Cum Bile 20-30 gram Concretio Silicea Bambusae 15-25 gram

Radix Notoginseng 20-30 gram Radix Astragali 10-20 gram Caulis Spatholobi 15-25 gram

Radix Et Rhizoma Rhei 20-30 gram Radix Paeoniae Rubra 5-15 gram Bungarus Parvus 10-20 gram

Semen Persicae 5-15 gram Rhizoma Gastrodiae 15-25 Keshan short, bristly hair or beard 10-14 gram

Concha Haliotidis 15-25 gram

Wherein, be preferably

Radix Salviae Miltiorrhizae 20 gram Radix Glycyrrhizaes 10 gram Radix Puerariaes 30 grams

Flos Carthami 15 gram Arisaema Cum Bile 25 gram Concretio Silicea Bambusaes 20 grams

The Radix Notoginseng 25 gram Radixs Astragali 15 gram Caulis Spatholobis 20 grams

Radix Et Rhizoma Rhei 25 gram Radix Paeoniae Rubra 10 gram Bungarus Parvus 15 grams

Semen Persicae 10 gram Rhizoma Gastrodiaes 20 Keshan short, bristly hair or beards 12 grams

Concha Haliotidis 20 grams

The preparation method of medicine of the present invention is as follows

One, gets the raw materials ready

1, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

2, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;

3, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;

4, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

5, Arisaema Cum Bile: get crude drug, choose decontamination;

6, Concretio Silicea Bambusae: get crude drug, remove impurity, ash bits;

7, Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;

8, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

9, Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

10, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

11, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;

12, Bungarus Parvus: get crude drug, remove bamboo let and head, the time spent cutting;

13, Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

14, Rhizoma Gastrodiae: Rhizoma Gastrodiae slice is tiled on the watch core paper that sprayed water, puts in the pot, burn to the paper color with slow fire sallow, constantly tablet is stirred to the two sides strong yellow for the degree;

15, Fructus Crataegi: choose clean impurity, the sieve enucleation;

16, Concha Haliotidis: clean and dry the knock fragment.

Two, preparation

1, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Radix Puerariae, Flos Carthami, Arisaema Cum Bile, Concretio Silicea Bambusae, Radix Notoginseng, the Radix Astragali, Caulis Spatholobi, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Bungarus Parvus, Semen Persicae, Rhizoma Gastrodiae, Fructus Crataegi, Concha Haliotidis, the Fructus Evodiae with described weight decocts with water, add for the first time 6 times of amounts of water, intense fire decocts boiling 30 minutes, use again slow fire boiling 40 minutes, and namely got for the first time decoction liquor.

2, will filter for the first time rear medicinal residues and add 4 times of amounts of water, decoct boiling, namely get for the second time decoction liquor in 15 minutes with slow fire boiling again.

3, twice decoction liquor mixed, namely get and take medicament.

Medicine of the present invention has suppressing the hyperactive liver and subsiding YANG, promoting blood circulation to remove obstruction in the collateral, and eliminating phlegm and calming wind, the effect that Xuan Yu has one's ideas straightened out, treatment apoplexy instant effect, short treating period do not recur.

Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day twice, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 140 examples for medical treatment, male patient's 100 examples wherein, female patient 40 examples.

2, diagnostic criteria

Paralytic's common sympton has

1. mouthful out-of-the-way facial paralysis that is commonly called as, cardinal symptom is facial hemiparalysis, how with pain behind the ear, because of facial hemiparalysis sometimes wake saliva, slurred speech.How by positive QI-insufficiency, ailment said due to cold or exposure people's median nexus is due to the resistance of QI and blood numbness, all ages and classes all can be suffered from, and apoplexy crooked mouth and tongue person is many with quadriplegia or hemianesthesia, and is sick disorderly contrary by QI and blood, bleeding resulting from adverse flow of QI, on disturb the brain key and to cause the refreshing machine of brains impaired, and take middle-aged and elderly people as many.

2. the ailing disease of epilepsy and Apoplexy Hitting Viscera all have the right dusk servant's of soldier the disease of seeing.And the epilepsy disease is paroxysmal disease, tic of the limbs during stupor, and slobbering, two fixed staring upward, or make unusual cry, and it is rear just like ordinary person to wake up, and how normal limb activity is, and it is in the majority with teenager to fall ill.

3. faint the card coma often with the extremity cold of the limbs, revive when generally moving, it is rear without diseases such as hemiplegia, crooked mouth and tongue, aphasias to wake up.

4. convulsive diseases are with tic of the limbs, stiffness of the nape and back, even opisthotonus is primary symptom.Sick sending out also can be accompanied coma, but without symptoms such as hemiplegia, crooked mouth and tongue, aphasias.

The flaccidity disease relax take brothers' weakness, muscle arteries and veins do not receive, amyotrophy is as primary symptom, onset is slow, during onset without the syncope of fainting suddenly, crooked mouth and tongue, aphasia.Take two lower limb or extremity as common, or see that the limb of suffering from amyotrophy is arranged, or see that muscular twitching pities.Apoplexy also has the limb muscle of opinion atrophy person, be more common in sequela stage by hemiplegia useless with due to.

3, Therapeutic Method

Select above-mentioned medicament, take to the patient, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 20 days is a course for the treatment of, takes continuously four courses for the treatment of.

4, efficacy assessment standard

Produce effects: clinical symptom disappearance after the treatment, body constitution recover normal, observe half a year without the recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;

Invalid: clinical partial symptoms disappears or without change, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, with Drug therapy paralytic's 140 examples of the present invention, produce effects 134 examples as a result, obvious effective rate is 95.71%, 4 examples that take a turn for the better, improvement rate is 2.86%, invalid 2 examples, total effective rate is 98.57%.

Claims

1. medicine for the treatment of apoplexy, it is characterized in that: it is to be made by the crude drug in the following weight scope:

Concha Haliotidis 15-25 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Concha Haliotidis 20 grams.

3. the preparation method of described medicine according to claim 1 and 2, it is characterized in that: it comprises the following steps:

(1) gets the raw materials ready

(1) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(2) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;

(3) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;

(4) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(5) Arisaema Cum Bile: get crude drug, choose decontamination;

(6) Concretio Silicea Bambusae: get crude drug, remove impurity, ash bits;

(7) Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;

(8) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(9) Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

(10) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

(11) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;

(12) Bungarus Parvus: get crude drug, remove bamboo let and head, the time spent cutting;

(13) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

(14) Rhizoma Gastrodiae: Rhizoma Gastrodiae slice is tiled on the watch core paper that sprayed water, puts in the pot, burn to the paper color with slow fire sallow, constantly tablet is stirred to the two sides strong yellow for the degree;

(15) Fructus Crataegi: choose clean impurity, the sieve enucleation;

(16) Concha Haliotidis: clean and dry the knock fragment;

(2) preparation

(1) Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Radix Puerariae, Flos Carthami, Arisaema Cum Bile, Concretio Silicea Bambusae, Radix Notoginseng, the Radix Astragali, Caulis Spatholobi, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Bungarus Parvus, Semen Persicae, Rhizoma Gastrodiae, Fructus Crataegi, the Concha Haliotidis with described weight decocts with water, add for the first time 6 times of amounts of water, intense fire decocts boiling 30 minutes, use again slow fire boiling 40 minutes, and namely got for the first time decoction liquor;

(2) will filter for the first time rear medicinal residues and add 4 times of amounts of water, decoct boiling, namely get for the second time decoction liquor in 15 minutes with slow fire boiling again;

(3) twice decoction liquor mixed, namely get and take medicament.