CN103638502B - Medicament for treating behcet disease and preparation method of medicament - Google Patents

Medicament for treating behcet disease and preparation method of medicament Download PDF

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CN103638502B
CN103638502B CN201310671943.2A CN201310671943A CN103638502B CN 103638502 B CN103638502 B CN 103638502B CN 201310671943 A CN201310671943 A CN 201310671943A CN 103638502 B CN103638502 B CN 103638502B
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苏振华
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苏振华
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Abstract

The invention discloses a medicament for treating behcet disease and a preparation method of the medicament. The medicament is mainly prepared from rhizoma curculiginis, tripterygium glycosides, honeysuckle stem, amomum tsao-ko, dark plum, gecko, dandelion, carpesium abrotanoides, talc, juncus effuses, feather cockscomb seed and the like in a certain weight ratio. The medicament has the efficacies of clearing heat, stopping blood, killing pests and diminishing inflammation, and has a quick effect and a good treatment effect when the medicament is used for treating the behcet disease; the behcet disease does not relapse after being cured.

Description

A kind of medicine for the treatment of Behcet disease and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of Behcet disease and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Behcet disease is a kind of general immune system disease, the multiple organ of human body can be encroached on, comprise oral cavity, skin, articular muscle, eyes, blood vessel, heart, lung and nervous system etc., main manifestations is repeatedly oral cavity and perineal position ulcer, erythra, lower limb erythema nodosa, eye iritis, esophageal ulcer, small intestinal or colonic ulcer and arthralgia etc.At present, because Western medicine effectively cannot treat Behcet disease, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating Behcet disease.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment Behcet disease, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating Behcet disease.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Rhizoma Curculiginis, Radix Tripterygii Wilfordii, Caulis Lonicerae, Fructus Tsaoko, Fructus Mume, Gekko Swinhonis, Herba Taraxaci, Radix Carpesii, Talcum, Medulla Junci, Semen Celosiae, Semen Cuscutae, Semen Ziziphi Spinosae, Carapax Trionycis, Herba Dendrobii, Nidus Vespae, Radix Pseudostellariae, Cortex Lycii, Carapax et Plastrum Testudinis, Rhizoma Zingiberis, Radix Gentianae, Radix Curcumae, Ramulus Cinnamomi, Cornu Bubali, Herba Portulacae Grandiflorae, the Rhizoma Anemarrhenae, Folium Isatidis, Folium Bambusae, Bulbus Lilii, Flos Chrysanthemi Indici, Herba Schizonepetae medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat Behcet disease.Wherein select Rhizoma Curculiginis to be because its nature and flavor are pungent, temperature, poisonous, enter kidney, Liver Channel, have the kidney warming sun, the function of strengthening bone and muscle, controls sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula.Radix Tripterygii Wilfordii is selected to be that poison, has parasite killing, antiinflammatory, the function of removing toxic substances greatly because its nature and flavor are bitter.Caulis Lonicerae is selected to be because its nature and flavor are sweet, cold, enter the heart, lung meridian, have heat clearing away, removing toxic substances, the function of dredging collateral, control epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.Select Fructus Tsaoko to be because its property and flavor of peppery and warm, return taste warp, have dampness warming middle-JIAO, the function of expectorant preventing the attack (or recurrence) of malaria, control cold temperature internal resistance, feeling of fullness is vomitted.Fructus Mume is selected to be that temperature, enter liver, spleen, lung, large intestine channel, have convergence to promote the production of body fluid, the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, and dysentery, has blood in stool, hematuria, metrorrhagia, and the ascariasis of biliary tract is suffered from abdominal pain, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp because its nature and flavor acid.Select Gekko Swinhonis to be because its nature and flavor are salty, cold, slightly poisonous, dispel the wind, arresting convulsion, eliminating stagnation, the function of removing toxic substances, controls paralysis due to windstroke, severe and migratory arthralgia pain, wind-phlegm Jing Epilepsy, scrofula, malignant boil.Select Herba Taraxaci to be because its property bitter but sweet flavor, cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select Radix Carpesii to be because its nature and flavor are pungent, cold, enter liver, lung meridian, eliminate the phlegm, heat clearing away, removing blood stasis, hemostasis, removing toxic substances, the function of parasite killing, controls tonsillitis, sore throat, malaria, acute hepatitis, anxious chronic infantile convulsion, malnutrition due to parasitic infestation, abdominal mass due to blood stasis, epistaxis, stranguria with blood, and furuncle swells sore, itchy skin eruption.Talcum is selected to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, have inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat, control hematodiarrhoea, gonorrhea, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Select Medulla Junci to be because its property slightly sweet flavor, cold, enter the heart, lung, small intestine meridian, have clearing heart fire, the function of inducing diuresis for treating stranguria syndrome, controls gonorrhea, edema, dysuria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, wound.Semen Celosiae is selected to be that cool, enter Liver Channel, heat of dispeling the wind, the function of clearing away liver-fire, controls conjunctival congestion and swelling pain, hides from view, hypertension, epistaxis, skin wind heat pruritus, mange because its nature and flavor are bitter.Select Semen Cuscutae to be because its property acrid-sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quench one's thirst, dripping urination, order is dark.Semen Ziziphi Spinosae is selected to be that flat, enter the heart, spleen, liver, gallbladder meridian, have nourishing the liver, mind calming, calm the nerves, the function of arresting sweating, controls restlessness of asrhenia type and insomnia because its nature and flavor are sweet, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Carapax Trionycis is selected to be because its nature and flavor are salty, flat, enter liver, spleen channel, have replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, control consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly , mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Select Herba Dendrobii to be because its property slightly sweet flavor is micro-salty, cold, enter to have, lung, kidney channel, have the stomach reinforcing that promotes the production of body fluid, the function of clearing away heat and nourishing YIN, controls consumption of body fluid caused by febrile disease, and xerostomia is tired drinks, deficiency-heat after being ill, and it is dark that the moon hinders order.Select Nidus Vespae to be because its nature and flavor are sweet, flat, poisonous, enter Yangming Channel, dispel the wind, counteracting toxic substances, the function of parasite killing, Zhi Jing Epilepsy, migratory arthralgia, urticaria pruritus, acute mastitis, furunculosis, scrofula, anal fistula, acute toothache, tinea capitis, honeybee stings swollen pain.Radix Pseudostellariae is selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Optionally Cortex Lycii is because its nature and flavor are sweet, cold, and enter lung, liver, kidney channel, have heat clearing away, the function of removing heat from blood, control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Select Carapax et Plastrum Testudinis to be because its nature and flavor are salty sweet, flat, enter liver, kidney channel, have YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the function of strong bone, controls deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.Select Rhizoma Zingiberis to be that heat, enters spleen, stomach, lung meridian because its nature and flavor are pungent, have warming middle-JIAO by cold, the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomits and diarrhoea, cold extremities faint pulse, and cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, and yang deficiency is told, be defeated in battle, hematochezia.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat , Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Radix Curcumae is selected to be because its nature and flavor are worked hard, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select Ramulus Cinnamomi to be because its property acrid-sweet flavor, temperature, enter bladder, the heart, lung meridian, have diaphoresis expelling pathogenic factors from muscles, the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Cornu Bubali to be because its nature and flavor hardship is salty, cold, have the function of heat clearing away, removing heat from blood, removing toxic substances, control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.Select Herba Portulacae Grandiflorae to be that cold, have heat clearing away, the function of removing toxic substances, controls laryngopharynx swelling and pain because its nature and flavor are bitter, scald, traumatic injury, eczema.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Folium Isatidis is selected to be because its nature and flavor are bitter, cold, enter liver, the heart, stomach warp, have heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Select Folium Bambusae to be because its property slightly sweet flavor, cold, enter the heart, lung, gallbladder, stomach warp, have clearing heat and relieving fidgetness, the function of diuresis of promoting the production of body fluid, control that calentura is tired drinks, little youngster shies Epilepsy, and cough with dyspnea tells nosebleed, flushed complexion, oliguria with reddish urine, erosion of the oral mucosa tongue boil.Select Bulbus Lilii to be because its property sweet and slightly bitter taste, flat, enter the heart, lung meridian, have nourishing the lung to arrest cough, the function of clearing away heart-fire for tranquillization, control pulmonary tuberculosis chronic cough, cough and spit expectorant blood, after calentura, waste heat is unclear, and fidgets due to deficiency is palpitated with fear, staring spells, beriberi edema.Flos Chrysanthemi Indici is selected to be that cool, enter lung, Liver Channel, have wind and heat dispersing, the function of subduing swelling and detoxicating, controls anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters because its nature and flavor toil.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Rhizoma Curculiginis 5-15 Cray Tripterygium wilfordii 5-15 gram of Caulis Lonicerae 5-15 gram
Fructus Tsaoko 15-25 gram of Fructus Mume 25-35 gram of Gekko Swinhonis 10-20 gram
Herba Taraxaci 10-20 gram of Radix Carpesii 10-20 gram of Talcum 10-20 gram
Medulla Junci 25-35 gram of Semen Celosiae 25-35 gram of Semen Cuscutae 25-35 gram
Semen Ziziphi Spinosae 5-15 gram of Carapax Trionycis 5-15 gram of Herba Dendrobii 5-15 gram
Nidus Vespae 15-25 gram of Radix Pseudostellariae 15-25 gram of Cortex Lycii 15-25 gram
Carapax et Plastrum Testudinis 10-20 gram of Rhizoma Zingiberis 10-20 cron gallbladder 10-20 gram
Radix Curcumae 15-25 gram of Ramulus Cinnamomi 15-25 gram of Cornu Bubali 15-25 gram
Herba Portulacae Grandiflorae 15-25 gram of Rhizoma Anemarrhenae 25-35 gram of Folium Isatidis 10-20 gram
Folium Bambusae 5-15 gram of Bulbus Lilii 5-15 gram of Flos Chrysanthemi Indici 5-15 gram
Herba Schizonepetae 10-20 gram
Preferable amount is
Rhizoma Curculiginis 10 Cray Tripterygium wilfordii 10 grams of Caulis Loniceraes 10 grams
Fructus Tsaoko 20 grams of Fructus Mumes 30 grams of Gekko Swinhonis 15 grams
15 grams, Herba Taraxaci 15 grams of Radix Carpesiis 15 grams of Talcums
Medulla Junci 30 grams of Semen Celosiae 30 grams of Semen Cuscutae 30 grams
Semen Ziziphi Spinosae 10 grams of Carapax Trionycis 10 grams of Herba Dendrobiis 10 grams
Nidus Vespae 20 grams of Radix Pseudostellariaes 20 grams of Cortex Lycii 20 grams
15 grams, Carapax et Plastrum Testudinis 15 grams of Rhizoma Zingiberis 15 cron gallbladders
Radix Curcumae 20 grams of Ramulus Cinnamomi 20 grams of Cornu Bubalis 20 grams
Herba Portulacae Grandiflorae 20 grams of Rhizoma Anemarrhenaes 30 grams of Folium Isatidiss 15 grams
Folium Bambusae 10 grams of Bulbus Liliies 10 grams of Flos Chrysanthemi Indicis 10 grams
Herba Schizonepetae 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;
2, Radix Tripterygii Wilfordii: the root bark that removing is residual, soaks, cleans, run through, cut sheet, and dry, sieve removes chip;
3, Caulis Lonicerae: pick decontamination, is soaked in water, and runs through, and section, dries;
4, Fructus Tsaoko: pick clean impurity, to put in pot slow fire and fry to shell coke yellow and micro-ly to heave, take out slightly cool, stone roller shells, and sieves and gets core;
5, Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;
6, Gekko Swinhonis: get crude drug, removing impurity;
7, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
8, Radix Carpesii: pick clean impurity, dry;
9, Talcum: get crude drug, removing impurity, cleaning, drying;
10, Medulla Junci: get Medulla Junci and put in pot, above cover the pot that a bore is smaller, paste with blank sheet of paper, two pots of junctions, use brine sludge sealing, do not make to lose heart, and being calcined to blank sheet of paper is that coke yellow is ceased fire, and takes out after cooling completely;
11, Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, and removing impurity, dries;
12, Semen Cuscutae: sieve and remove impurity, cleans, dries;
13, Semen Ziziphi Spinosae: bamboo basket put into by former medicine, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, is pulled out by Semen Ziziphi Spinosae, dries;
14, Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;
15, Herba Dendrobii: get dry Herba Dendrobii, saturating with blister about to eighty per cant, stew to moisten, removing undesirable root and black branch, cutting, hits thin film, dries;
16, Nidus Vespae: clean, steams thoroughly, decocts into fritter, dry;
17, Radix Pseudostellariae: extract fibrous root, dry;
18, Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;
19, Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, cleans, dries, knock fritter;
20, Rhizoma Zingiberis: pick clean impurity, is soaked in water 3-6 hours, pulls out, cuts into slices or dices, dry after moistening;
21, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
22, Radix Curcumae: be soaked in water, cleans, pulls solarization out and dry in the air, run through, and section, dries;
23, Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;
24, Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;
25, Herba Portulacae Grandiflorae: pick clean impurity, removing rhizome, dries;
26, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;
27, Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;
28, Folium Bambusae: pick clean impurity, except destemming leaf, dries;
29, Bulbus Lilii: pick decontamination, black lobe, ash disposal of winnowing with a dustpan is considered to be worth doing;
30, Flos Chrysanthemi Indici: remove impurity, removing undesirable root, cleans cutting, dries;
31, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries.
Two, prepare
1, the Rhizoma Curculiginis of described weight, Radix Tripterygii Wilfordii, Caulis Lonicerae, Fructus Tsaoko, Fructus Mume, Gekko Swinhonis, Herba Taraxaci, Radix Carpesii, Talcum, Medulla Junci, Semen Celosiae, Semen Cuscutae, Semen Ziziphi Spinosae, Carapax Trionycis, Herba Dendrobii, Nidus Vespae, Radix Pseudostellariae, Cortex Lycii, Carapax et Plastrum Testudinis, Rhizoma Zingiberis, Radix Gentianae, Radix Curcumae, Ramulus Cinnamomi, Cornu Bubali, Herba Portulacae Grandiflorae, the Rhizoma Anemarrhenae, Folium Isatidis, Folium Bambusae, Bulbus Lilii, Flos Chrysanthemi Indici, Herba Schizonepetae medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 100 minutes, intense fire decocts boiling 15 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor.
2, add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 40 minutes, filters to obtain second time decoction liquor.
3, by twice decoction liquor mixing and stirring, be divided into 6 doses and take.
Medicine of the present invention has heat clearing away, hemostasis, parasite killing, antiinflammatory, effect of removing toxic substances, and treatment Behcet disease instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 172 example for medical treatment.
2, diagnostic criteria
Clinical manifestation
1. crowd is sent out well: this disease is found in all kinds of crowd of China, all can be ill from teenager to old man, the young and the middle aged is more common, and men and women all can fall ill.
2. oral ulcer: patient's main manifestations is repeatedly oral ulcer, pain, ulcer surface is comparatively dark, bottom mostly is white or yellow, can occur that multiple ulcer (is commonly called as that " aphtha ") comprises tongue, lip, maxillary, pharyngeal etc. at multiple position simultaneously.Most ulcer can take a turn for the better voluntarily, but normal recurrent exerbation, severe patient sharp ache, very affects feed.
3. genital ulcer: except oral ulcer, also can there is external genital ulcer in patient, as male and ulcers of female genital organs, the ulcer at these positions can be comparatively large, can be single-shot.
, there is inflamed eyes, pain, photophobia or visual deterioration, blurring of vision in 4. Eye disease: some patients also can show as eyes pathological changes, can one or two eyes get involved.
5. cutaneous manifestations: also dermatosis appears in some patient, shows as face, " " sample erythra, or the performance being similar to " furuncle ", can take a turn for the better comedo voluntarily, but easy recurrent exerbation for chest and back or other position.The patient had in addition there will be that lower limb are blue, swelling and pain, can touch " pimple ", the patient's lower limb also had there will be the erythema of recurrent exerbation, not of uniform size, can from Semen Glycines size to copper coin size, pain during pressing, this phenomenon is called " erythema nodosa ".The patient also had there will be redness or vesicle or pustule in transfusion or blood drawing pinprick local, and majority occurs in 24 ~ 72 hours after injection, and this phenomenon is called as, and " acupuncture reaction is " positive.
6. arthropathy: many patients there will be arthralgia or swelling, can single or multiple joint, and joint of the lower extremity is common, and arms and legs can be accompanied to ache, and hydrarthrosis, synovitis appear in severe patient.
7. Alimentary tract disease: the more common performance of another one is symptom of digestive tract, chest pain when comprising dysphagia or swallow, return that acid is heartburn, stomachache, diarrhoea, have pus or blood in stool, or oneself touch abdominal part and have enclosed mass, weight loss, to become thin, there is no appetite, these symptoms can all occur or only occur one of them, and the patient doing gastroscope or intestinal mirror can be apprised of " ulcer ".
8. vascular lesion: thrombophlebitis and deep venous thrombosis can appear in small part patient, all right pulmonary embolism of severe patient, patient breathes hard after can there is activity, feels suffocated, and chest pain is even fainted.Can there is aneurysm in the patient also had, cause localized plug, ischemia, can massive hemorrhage, even threat to life after aneurysm rupture.
9. nervous system lesion: the patient had can have one's fingers all thumbs, headache dizziness, nausea and vomiting, trick stolidity, pain or unable, also can there is the trick paralysis of side, serious to have a convulsion, to show the whites of one's eyes etc. similar " take out epilepsy " performance, these are likely that Behcet disease has damage nervous system.The position that nervous system is the most often got involved is brain stem, also shows in spinal cord, cerebral hemisphere, cerebellum and meninges, can occur brain atrophy.
10. General Symptoms: many patients accompany weak, poor appetite, low grade fever and the General Symptoms such as to become thin.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: transference cure, body constitution recovers normal, observes 1 year without recidivist;
Take a turn for the better: the state of an illness is clearly better, and body constitution is progressively recovered.
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy Behcet disease patient 172 example of the present invention, effective 163 examples of result, obvious effective rate is 94.77%, and take a turn for the better 7 examples, and improvement rate is 4.07%, and invalid 2 examples, total effective rate is 98.84%.

Claims (3)

1. treat a medicine for Behcet disease, it is characterized in that: it is made up of the crude drug in following weight range:
Rhizoma Curculiginis 5-15 Cray Tripterygium wilfordii 5-15 gram of Caulis Lonicerae 5-15 gram
Fructus Tsaoko 15-25 gram of Fructus Mume 25-35 gram of Gekko Swinhonis 10-20 gram
Herba Taraxaci 10-20 gram of Radix Carpesii 10-20 gram of Talcum 10-20 gram
Medulla Junci 25-35 gram of Semen Celosiae 25-35 gram of Semen Cuscutae 25-35 gram
Semen Ziziphi Spinosae 5-15 gram of Carapax Trionycis 5-15 gram of Herba Dendrobii 5-15 gram
Nidus Vespae 15-25 gram of Radix Pseudostellariae 15-25 gram of Cortex Lycii 15-25 gram
Carapax et Plastrum Testudinis 10-20 gram of Rhizoma Zingiberis 10-20 cron gallbladder 10-20 gram
Radix Curcumae 15-25 gram of Ramulus Cinnamomi 15-25 gram of Cornu Bubali 15-25 gram
Herba Portulacae Grandiflorae 15-25 gram of Rhizoma Anemarrhenae 25-35 gram of Folium Isatidis 10-20 gram
Folium Bambusae 5-15 gram of Bulbus Lilii 5-15 gram of Flos Chrysanthemi Indici 5-15 gram
Herba Schizonepetae 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Rhizoma Curculiginis 10 Cray Tripterygium wilfordii 10 grams of Caulis Loniceraes 10 grams
Fructus Tsaoko 20 grams of Fructus Mumes 30 grams of Gekko Swinhonis 15 grams
15 grams, Herba Taraxaci 15 grams of Radix Carpesiis 15 grams of Talcums
Medulla Junci 30 grams of Semen Celosiae 30 grams of Semen Cuscutae 30 grams
Semen Ziziphi Spinosae 10 grams of Carapax Trionycis 10 grams of Herba Dendrobiis 10 grams
Nidus Vespae 20 grams of Radix Pseudostellariaes 20 grams of Cortex Lycii 20 grams
15 grams, Carapax et Plastrum Testudinis 15 grams of Rhizoma Zingiberis 15 cron gallbladders
Radix Curcumae 20 grams of Ramulus Cinnamomi 20 grams of Cornu Bubalis 20 grams
Herba Portulacae Grandiflorae 20 grams of Rhizoma Anemarrhenaes 30 grams of Folium Isatidiss 15 grams
Folium Bambusae 10 grams of Bulbus Liliies 10 grams of Flos Chrysanthemi Indicis 10 grams
Herba Schizonepetae 15 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;
(2) Radix Tripterygii Wilfordii: the root bark that removing is residual, soaks, cleans, run through, cut sheet, and dry, sieve removes chip;
(3) Caulis Lonicerae: pick decontamination, is soaked in water, and runs through, and section, dries;
(4) Fructus Tsaoko: pick clean impurity, to put in pot slow fire and fry to shell coke yellow and micro-ly to heave, take out slightly cool, stone roller shells, and sieves and gets core;
(5) Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;
(6) Gekko Swinhonis: get crude drug, removing impurity;
(7) Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
(8) Radix Carpesii: pick clean impurity, dry;
(9) Talcum: get crude drug, removing impurity, cleaning, drying;
(10) Medulla Junci: get Medulla Junci and put in pot, above cover the pot that a bore is smaller, paste with blank sheet of paper, two pots of junctions, use brine sludge sealing, do not make to lose heart, and being calcined to blank sheet of paper is that coke yellow is ceased fire, and takes out after cooling completely;
(11) Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, and removing impurity, dries;
(12) Semen Cuscutae: sieve and remove impurity, cleans, dries;
(13) Semen Ziziphi Spinosae: bamboo basket put into by former medicine, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, is pulled out by Semen Ziziphi Spinosae, dries;
(14) Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;
(15) Herba Dendrobii: get dry Herba Dendrobii, saturating with blister about to eighty per cant, stew to moisten, removing undesirable root and black branch, cutting, hits thin film, dries;
(16) Nidus Vespae: clean, steams thoroughly, decocts into fritter, dry;
(17) Radix Pseudostellariae: extract fibrous root, dry;
(18) Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;
(19) Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, cleans, dries, knock fritter;
(20) Rhizoma Zingiberis: pick clean impurity, is soaked in water 3-6 hours, pulls out, cuts into slices or dices, dry after moistening;
(21) Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
(22) Radix Curcumae: be soaked in water, cleans, pulls solarization out and dry in the air, run through, and section, dries;
(23) Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;
(24) Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;
(25) Herba Portulacae Grandiflorae: pick clean impurity, removing rhizome, dries;
(26) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;
(27) Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;
(28) Folium Bambusae: pick clean impurity, except destemming leaf, dries;
(29) Bulbus Lilii: pick decontamination, black lobe, ash disposal of winnowing with a dustpan is considered to be worth doing;
(30) Flos Chrysanthemi Indici: remove impurity, removing undesirable root, cleans cutting, dries;
(31) Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
(2) prepare
(1) Rhizoma Curculiginis of described weight, Radix Tripterygii Wilfordii, Caulis Lonicerae, Fructus Tsaoko, Fructus Mume, Gekko Swinhonis, Herba Taraxaci, Radix Carpesii, Talcum, Medulla Junci, Semen Celosiae, Semen Cuscutae, Semen Ziziphi Spinosae, Carapax Trionycis, Herba Dendrobii, Nidus Vespae, Radix Pseudostellariae, Cortex Lycii, Carapax et Plastrum Testudinis, Rhizoma Zingiberis, Radix Gentianae, Radix Curcumae, Ramulus Cinnamomi, Cornu Bubali, Herba Portulacae Grandiflorae, the Rhizoma Anemarrhenae, Folium Isatidis, Folium Bambusae, Bulbus Lilii, Flos Chrysanthemi Indici, Herba Schizonepetae medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 100 minutes, intense fire decocts boiling 15 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor;
(2) add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 40 minutes, filters to obtain second time decoction liquor;
(3) by twice decoction liquor mixing and stirring, be divided into 6 doses and take.
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CN101091783A (en) * 2005-12-10 2007-12-26 刘汉光 Preparation of Chinese traditional medicine for treating HIV infection, AIDS, tumours etc. multiple difficult diseases
CN101121013A (en) * 2006-08-07 2008-02-13 郭占友 Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method

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* Cited by examiner, † Cited by third party
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CN101091783A (en) * 2005-12-10 2007-12-26 刘汉光 Preparation of Chinese traditional medicine for treating HIV infection, AIDS, tumours etc. multiple difficult diseases
CN101121013A (en) * 2006-08-07 2008-02-13 郭占友 Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method

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