CN105617287A

CN105617287A - Medicine for treating Behcet's disease

Info

Publication number: CN105617287A
Application number: CN201610160888.4A
Authority: CN
Inventors: 刘琴兰
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-21
Filing date: 2016-03-21
Publication date: 2016-06-01

Abstract

The invention relates to a medicine for treating Behcet's disease. The medicine is prepared from the following raw herbs by weight: 22 parts of herba violae, 20 parts of caulis lonicerae, 9 parts of semen celosiae, 12 parts of rhizoma polygoni cuspidati, 6 parts of rhizoma curcumae, 10 parts of cortex dictamni, 6 parts of fructus cnidii and 6 parts of spina gleditsiae. Herba violae can clear away heat and toxic materials and cool blood to eliminate swelling; caulis lonicerae can clear away heat and toxic materials and dredge the channels; semen celosiae can eliminate wind and heat, clear away liver-fire and remove nebula; rhizoma polygoni cuspidati can promote blood flow to remove stasis, dispel wind and remove obstruction in the meridians, clear heat and promote diuresis, and detoxify; rhizoma curcumae can promote qi circulation to break blood, and remove qi stagnation to relieve pain; cortex dictamni can clear away heat and dry dampness, dispel wind and arrest itching, and detoxify; fructus cnidii can warm the kidney to strengthen yang, remove dampness and destroy parasites, and dispel wind and arrest itching; spina gleditsiae can disinfect to promote pus drainage, and search wind and destroy parasites. All the herbs are used together to achieve the effects of tonifying the spleen and kidney, activating yang and promoting blood flow, replenishing qi and enriching the blood, detoxifying to heal sores. Clinical experiments testify that the medicine provided by the invention can can safely and effectively treat Behcet's disease.

Description

A kind of medicine being used for the treatment of Behcet's disease

Technical field

The present invention relates to a kind of Chinese medicine, it is specifically related to a kind of medicine being used for the treatment of Behcet's disease.

Background technology

Behcet's disease, also known as behcet syndrome, is the general immune system disease of a kind of Multisystem damage taking tiny vasculitis as pathologic basis, belongs to the one of vasculitis. It can encroach on the multiple organ of human body, comprise oral cavity, skin, joint muscle, eyes, blood vessel, heart, lung and neural system etc., mainly show as repeatedly oral cavity and perineal position ulcer, fash, lower limb erythema nodosa, eye iritis, esophageal ulcer, small intestine or colonic ulcer and arthralgia etc. Morbidity and bacterium, virus infection, drug allergy, the factors such as autoimmune response are relevant. Behcet's disease is common with women, and the principal pathogenetic age, the general state of an illness was relatively light, and prognosis is good at 16��40 years old. Behcet's disease needs the pharmacological agent of rule, comprises the medicine of various immunity moderation, does not treat then prognosis not good, and as involved cardiovascular injuries, digestive tube, neural system person, its prognosis is then relevant with involved organs and severity thereof, and severe patient jeopardizes life. Behcet's disease belongs to " the puzzled disease of fox " category of the traditional Chinese medical science.

The cause of disease

The pathogenic factor of current Behcet's disease is not exclusively clear, it is possible to heredity (such as HLA-B51 gene), infect (part patient may with tuberculosis infection be correlated with), living environment relevant. It is now recognized that, the pathogenesis of this disease is that patient immune system dysfunction occurs under the effect of various pathogenic factor, comprise cellular immunization and humoral immunization not normal, neutrophilic granulocyte hyperfunction, endothelial cell damage and thrombosis, immunity system produce reaction for self organ-tissue, cause organ-tissue that inflammation occurs, produce to destroy.

Clinical manifestation

1. crowd is sent out well

Behcet's disease is found in all kinds of crowd of China, all can be ill from teenager to old man, and the young and the middle aged is more common, and men and women all can fall ill.

2. stomatocace

Patient mainly shows as repeatedly stomatocace, pain, and ulcer surface is relatively dark, bottom mostly is white or yellow, it is possible to multiple ulcer (being commonly called as " aphtha ") occur at multiple position simultaneously, comprises tongue, lip, maxilla, pharyngeal etc. Most ulcer can take a turn for the better voluntarily, but normal recurrent exerbation, severe patient sharp ache, affects feed very much.

3. genital ulcer

Except stomatocace, also can there is external genital ulcer in patient, and such as the male sex and female sex organs ulcer, the ulcer at these positions can be bigger, it is possible to is single-shot.

4. Eye disease

Part patient also can show as eyes pathology, inflamed eyes, pain, photophobia or visual deterioration, blurring of vision occurs, it is possible to one or two eyes are got involved.

5. cutaneous manifestations

Also there is dermatosis in some patient, shows as face, " " sample fash, or be similar to the performance of " furuncle ", can take a turn for the better comedo voluntarily, but easy recurrent exerbation for chest and back or other positions. The patient having in addition there will be lower limb cyanosis, swelling and pain, it is possible to touches " pimple ", and the patient's lower limb also having there will be the erythema of recurrent exerbation, not of uniform size, can from soya bean to copper coin size, pain during pressing, this kind of phenomenon is called " erythema nodosa ". The patient also having there will be redness or blister or warts in transfusion or blood drawing pinprick local, and majority occurs in 24��72 hours after injection, and this kind of phenomenon is called as " acupuncture reaction " positive.

6. joint pathology

Many patients there will be arthralgia or swelling, it is possible to single or multiple joint, and Joint of lower extremity is common, it is possible to companion's arms and legs pain, hydrarthrosis, synovitis occurs in severe patient.

7. Alimentary tract disease

The more common performance of another one is symptom of digestive tract, pectoralgia when comprising dysphagia or swallow, anti-sour, heartburn, stomachache, diarrhoea, defecate in have purulence or blood, or oneself touch belly and have enclosed mass, weight loss, become thin, there is no appetite, these symptoms can all occur or only occur one of them, and the patient doing gastroscope or intestines mirror can be apprised of " ulcer ".

8. blood vessel pathology

Can there is thrombophlebitis and deep venous thrombosis in small part patient, and all right concurrent pulmonary infarction of severe patient, patient breathes hard after can there is activity, feels suffocated, and chest pain is even fainted. Also have patient aneurysma can occur, cause local embolism, ischemic, after aneurysm rupture can profuse bleeding, even jeopardize life.

9. nervous system lesion

Some patients can have trick not flexibly, headache dizziness, nausea and vomiting, trick sensation numbness, pain or unable, the trick paralysis of side also can occur, the performance of serious occurred tic, show the whites of one's eyes etc. similar " taking out epilepsy ", these are likely that behcet syndrome has damage neural system. The position that neural system is the most often got involved is brain stem, it is possible to see spinal cord, hemicerebrum, cerebellum and meninges, it is possible to encephalatrophy occur.

10. constitutional symptom

Many patients accompany weak, receive poor, low-heat and the constitutional symptom such as become thin.

Pharmacological agent

1. most of patients needs longer-term to take medicine, mainly immunomodulator or immunosuppressive drug, comprises externally applied medicine, oral glucocorticoid, methotrexate, colchicine, Thalidomide, azathioprine, endoxan, ciclosporin, mycophenolate mofetile and anti-tumor necrosis factor antagonist etc.

2. treatment by Chinese herbs is started with marrow, whole body therapeutic, makes illness start to take a turn for the better, and human body recovers normal physiological function.

Medicinal material involved in the present invention is recorded in " China's book on Chinese herbal medicine " all as seen.

Summary of the invention

The medicine being used for the treatment of Behcet's disease it is desirable to provide a kind of, by selecting suitable medicinal material and proportioning thereof, reaches the object of safe and effective healing Behcet's disease.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of medicine being used for the treatment of Behcet's disease, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Philippine Violet Herb 22 parts, Japanese Honeysuckle Stem 20 parts, Semen Celosiae 9 parts, giant knotweed 12 parts, curcuma zedoary 6 parts, Root-bark of Densefruit Pittany 10 parts, Fructus Cnidii 6 parts, Spine of Chinese Honeylocust 6 parts.

Below in conjunction with theories of Chinese materia medica, the useful effect of the present invention is described:

Contriver thinks, the cause of disease of Behcet's disease, interior because ferritic yin asthenia generating intrinsic heat, outer because the heresy of impression heat poison, causes to accumulate and poisons corruption, contains and be disease in stagnant heat. Pathological change is ferritic yin asthenia generating intrinsic heat, and the heresy of multiple sensible heat poison, pents up in interior, burn bright ying blood, changes the rotten one-tenth stasis of blood, and upper erosion eye mouth, causes eye mouth and fester; Lower damage two is cloudy, causes two the moon and festers. Of a specified duration then the hepatic and renal YIN deficiency, or deficiency of spleen-YANG and kidneyYANG, deficient vital QI leading to lingering of pathogen, gas blood all loses surveys blood stasis of blood phlegm knot, and ulcer difficulty is more. Therefore treatment is then taked clearing heat and detoxicating, the moon is protected in purging intense heat, nourishing liver and kidney, removing toxic substances of invigorating blood circulation.

The present invention uses: Philippine Violet Herb is clearing heat and detoxicating, and cool blood is subsided a swelling; Japanese Honeysuckle Stem is clearing heat and detoxicating, logical network; Semen Celosiae dispels the wind heat, clearing away the liver-fire, improving acuity of vision and removing nebula; Giant knotweed promoting blood circulation to remove blood stasis, dispelling wind and removing obstruction in the collateral, clearing heat and promoting diuresis, removing toxic substances; Blood is broken in curcuma zedoary promoting the circulation of qi, and disappear long-pending pain relieving; Root-bark of Densefruit Pittany heat-clearing and damp-drying drug, dispellings wind and arresting itching, removing toxic substances; Fructus Cnidii warming the kidney to invigorate YANG, removing dampness and killing parasites, dispellings wind and arresting itching; Spine of Chinese Honeylocust is sterilized purulence, searches wind and kills worm. All medicines share, reach tonifying spleen and kidney, activating yang to invigorate blood circulation, benefiting vital QI for enriching blood, removing toxic substances sore effect.

The useful effect of the present invention is described below in conjunction with clinical experiment data:

1, physical data

Contriver collects 75 example Behcet's disease patients altogether between in March ,-2015 in June, 2012. It is divided at random: treatment group 38 example, control group 37 example. Wherein treatment group man 16 is routine, female 22 is routine, 18��63 years old age, the course of disease 2 months��3 years; Control group man 13 example, female 24 example, between 18��60 years old age, the course of disease 3 months��4 years. The data there was no significant differences such as two groups of sexes, age, courses of disease, have comparability.

Case definition

1. stomatocace repeatedly: have doctor to observe or patient has told aphtha or scar, recurrent exerbation >=3 time in 1 year.

2. genital ulcer repeatedly: have doctor to observe or patient tells that sexual organ have aphtha, the especially male sex.

3. illness in eye becomes: front and (or) posterior uveitis, has cellular infiltration as seen in vitreum during slit lamp examination, or retinal vasculitis.

4. dermatosis: erythema nodosa sample pathology, vacation folliculitis, purulence papule, acneform eruptions (not taking glucocorticosteroid and the person of appearance).

5. acupuncture reacting positive: with No. 20 aseptic syringe needles, stabbing diagonally in skin, 24��48h is by doctor's result of determination.

All have repeatedly stomatocace and with 2 persons in all the other 4, can make a definite diagnosis as this disease.

1. standard of including in meets Case definition; 2. age 18��70 years old; 3. compliance is good; 4. Informed Consent Form is signed voluntarily.

Exclusion standard is pregnant, lactating women 1.; 2. suffer from severe cardiac, lung, liver, renal disease patient; 3. there is psychosis, can not partner treatment person; 4. through the patient of other drug treatment after morbidity.

2, methods for the treatment of

The treatment group obtained capsule of oral present invention specific embodiment 3, every day 3 times. Treat 1 month.

The oral Thalidomide sheet of control group, each 40mg, every day 3 times. Treat 1 month.

3, criterion of therapeutical effect and treatment result

3.1 criterion of therapeutical effect

1. fully recovering: the symptom and signs such as oral cavity, vulva, eye, skin disappear, the every Index for examination in laboratory recovers normal;

2. effective: partial symptoms sign disappears or primary symptom shape improves, and the every Index for examination in laboratory makes moderate progress;

3. invalid: the every Index for examination of symptom and sign and laboratory is unchanged or increases the weight of.

3.2 treatment statisticses are in table 1.

Table 1 liang group comparitive study

Visible, the medicine that the present invention obtains can safe and effective treatment Behcet's disease, curative ratio height.

Embodiment

In order to understand better and implement the present invention, below in conjunction with specific embodiment, the present invention is described further.

Embodiment 1

Take: Philippine Violet Herb 22 grams, Japanese Honeysuckle Stem 20 grams, Semen Celosiae 9 grams, giant knotweed 12 grams, curcuma zedoary 6 grams, Root-bark of Densefruit Pittany 10 grams, Fructus Cnidii 6 grams, Spine of Chinese Honeylocust 6 grams; The times amount water that adds 8, decocts and boils 1.5 hours, filters; Filter residue adds 6 times amount water, decocts and boils 1 hour, filters; Merging filtrate, concentrates to 120 grams, must meet the decoction of normal adult one day consumption.

It is used for the treatment of Behcet's disease. Oral, daily once.

Embodiment 2

Take: Philippine Violet Herb 22 grams, Japanese Honeysuckle Stem 20 grams, Semen Celosiae 9 grams, giant knotweed 12 grams, curcuma zedoary 6 grams, Root-bark of Densefruit Pittany 10 grams, Fructus Cnidii 6 grams, Spine of Chinese Honeylocust 6 grams; The times amount water that adds 10, decocts and boils 2 hours, filters; Filter residue adds 8 times amount water, decocts and boils 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of normal adult one day consumption.

It is used for the treatment of Behcet's disease. Oral, divide every day and sooner or later take for twice.

Embodiment 3

Take: Philippine Violet Herb 22 grams, Japanese Honeysuckle Stem 20 grams, Semen Celosiae 9 grams, giant knotweed 12 grams, curcuma zedoary 6 grams, Root-bark of Densefruit Pittany 10 grams, Fructus Cnidii 6 grams, Spine of Chinese Honeylocust 6 grams; The times amount water that adds 6, decocts and boils 3 times, decocts every time and boils 1 hour, merges decoction liquor, concentrated, dry, loads capsule shell, must meet the capsule of normal adult one day consumption.

It is used for the treatment of Behcet's disease. Oral, divide every day take for three times morning, noon and afternoon.

Claims

1. one kind is used for the treatment of the medicine of Behcet's disease, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Philippine Violet Herb 22 parts, Japanese Honeysuckle Stem 20 parts, Semen Celosiae 9 parts, giant knotweed 12 parts, curcuma zedoary 6 parts, Root-bark of Densefruit Pittany 10 parts, Fructus Cnidii 6 parts, Spine of Chinese Honeylocust 6 parts.

2. a kind of medicine being used for the treatment of Behcet's disease as claimed in claim 1, it is characterized in that, its preparation method is: take: Philippine Violet Herb 22 parts, Japanese Honeysuckle Stem 20 parts, Semen Celosiae 9 parts, giant knotweed 12 parts, curcuma zedoary 6 parts, Root-bark of Densefruit Pittany 10 parts, Fructus Cnidii 6 parts, Spine of Chinese Honeylocust 6 parts; The times amount water that adds 8, decocts and boils 1.5 hours, filters; Filter residue adds 6 times amount water, decocts and boils 1 hour, filters; Merging filtrate, concentrates to 120 parts, obtains decoction; Above-mentioned part all refers to weight part.

3. a kind of medicine being used for the treatment of Behcet's disease as claimed in claim 1, it is characterized in that, its preparation method is: take: Philippine Violet Herb 22 parts, Japanese Honeysuckle Stem 20 parts, Semen Celosiae 9 parts, giant knotweed 12 parts, curcuma zedoary 6 parts, Root-bark of Densefruit Pittany 10 parts, Fructus Cnidii 6 parts, Spine of Chinese Honeylocust 6 parts; The times amount water that adds 10, decocts and boils 2 hours, filters; Filter residue adds 8 times amount water, decocts and boils 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight part.

4. a kind of medicine being used for the treatment of Behcet's disease as claimed in claim 1, it is characterized in that, its preparation method is: take: Philippine Violet Herb 22 parts, Japanese Honeysuckle Stem 20 parts, Semen Celosiae 9 parts, giant knotweed 12 parts, curcuma zedoary 6 parts, Root-bark of Densefruit Pittany 10 parts, Fructus Cnidii 6 parts, Spine of Chinese Honeylocust 6 parts; The times amount water that adds 6, decocts and boils 3 times, decocts every time and boils 1 hour, merges decoction liquor, concentrated, dry, loads capsule shell, obtains capsule; Above-mentioned part all refers to weight part.