CN103638502A - Medicament for treating behcet disease and preparation method of medicament - Google Patents

Abstract

The invention discloses a medicament for treating behcet disease and a preparation method of the medicament. The medicament is mainly prepared from rhizoma curculiginis, tripterygium glycosides, honeysuckle stem, amomum tsao-ko, dark plum, gecko, dandelion, carpesium abrotanoides, talc, juncus effuses, feather cockscomb seed and the like in a certain weight ratio. The medicament has the efficacies of clearing heat, stopping blood, killing pests and diminishing inflammation, and has a quick effect and a good treatment effect when the medicament is used for treating the behcet disease; the behcet disease does not relapse after being cured.

Description

A kind of medicine for the treatment of Behcet disease and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of Behcet disease and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Behcet disease is a kind of general disease of immune system, can encroach on a plurality of organs of human body, comprise oral cavity, skin, articular muscle, eyes, blood vessel, heart, lung and nervous system etc., main manifestations is oral cavity and perineal position ulcer, erythra, lower limb erythema nodosa, eye iritis, esophageal ulcer, small intestinal or colonic ulcer and arthralgia etc. repeatedly.At present, because Western medicine cannot effectively be treated Behcet disease, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effective treatment Behcet disease.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment Behcet disease, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can effectively treat Behcet disease.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Rhizoma Curculiginis, Radix Tripterygii Wilfordii, Caulis Lonicerae, Fructus Tsaoko, Fructus Mume, Gekko Swinhonis, Herba Taraxaci, Radix Carpesii, Talcum, Medulla Junci, Semen Celosiae, Semen Cuscutae, Semen Ziziphi Spinosae, Carapax Trionycis, Herba Dendrobii, Nidus Vespae, Radix Pseudostellariae, Cortex Lycii, Carapax et Plastrum Testudinis, Rhizoma Zingiberis, Radix Gentianae, Radix Curcumae, Ramulus Cinnamomi, Cornu Bubali, Herba Portulacae Grandiflorae, the Rhizoma Anemarrhenae, Folium Isatidis, Folium Bambusae, Bulbus Lilii, Flos Chrysanthemi Indici, Herba Schizonepetae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat Behcet disease.Wherein select Rhizoma Curculiginis to be because its nature and flavor are pungent, temperature, poisonous, enter kidney, Liver Channel, there is the kidney warming sun, the function of strengthening bone and muscle, controls sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula.Select Radix Tripterygii Wilfordii to be because its nature and flavor are bitter, poison, has parasite killing, antiinflammatory, the function of removing toxic substances greatly.Select Caulis Lonicerae to be because its nature and flavor are sweet, cold, enter the heart, lung meridian, there is heat clearing away, removing toxic substances, the function of dredging collateral, controls epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.Select Fructus Tsaoko to be because its property and flavor of peppery and warm is returned taste warp, have dampness warming middle-JIAO, the function of expectorant preventing the attack (or recurrence) of malaria, controls cold warm internal resistance, feeling of fullness vomiting.Select Fructus Mume to be because its nature and flavor are sour, temperature, enters liver, spleen, and lung, large intestine channel, has convergence to promote the production of body fluid, and the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, dysentery, has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.Select Gekko Swinhonis to be because its nature and flavor are salty, cold, slightly poisonous, dispel the wind, arresting convulsion, eliminating stagnation, the function of removing toxic substances, controls paralysis due to windstroke, severe and migratory arthralgia pain, wind-phlegm Jing Epilepsy, scrofula, malignant boil.Select Herba Taraxaci to be because its property bitter but sweet flavor is cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select Radix Carpesii to be because its nature and flavor are pungent, cold, enter liver, lung meridian, eliminate the phlegm, heat clearing away, removing blood stasis, hemostasis, removing toxic substances, the function of parasite killing, controls tonsillitis, sore throat, malaria, acute hepatitis, anxious chronic infantile convulsion, malnutrition due to parasitic infestation, abdominal mass due to blood stasis, epistaxis, stranguria with blood, the furuncle sore that swells, itchy skin eruption.Select Talcum to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, there is inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat, controls hematodiarrhoea, gonorrhea, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Select Medulla Junci to be because its property slightly sweet flavor is cold, enter the heart, lung, small intestine meridian, have clearing heart fire, the function of inducing diuresis for treating stranguria syndrome, controls gonorrhea, edema, dysuria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, wound.Select Semen Celosiae to be because its nature and flavor are bitter, cool, enter Liver Channel, the heat of dispeling the wind, the function of clearing away liver-fire, controls conjunctival congestion and swelling pain, hides from view, hypertension, epistaxis, skin wind heat pruritus, mange.Select Semen Cuscutae to be because its property acrid-sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quenches one's thirst, dripping urination, order is dark.Select Semen Ziziphi Spinosae to be because its nature and flavor are sweet, flat, enter the heart, spleen, liver, gallbladder meridian, there is nourishing the liver, mind calming, calms the nerves, and the function of arresting sweating, controls restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Select Carapax Trionycis to be because its nature and flavor are salty, flat, enter liver, spleen channel, there is replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, controls consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly ， mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Select Herba Dendrobii to be because its property slightly sweet flavor is micro-salty, cold, enter to have, lung, kidney channel, there is the stomach reinforcing of promoting the production of body fluid, the function of clearing away heat and nourishing YIN, controls consumption of body fluid caused by febrile disease, and xerostomia is tired drinks, deficiency-heat after being ill, it is dark that the moon is hindered order.Select Nidus Vespae to be because its nature and flavor are sweet, flat, poisonous, enter Yangming Channel, dispel the wind, counteracting toxic substances, the function of parasite killing, Zhi Jing Epilepsy, migratory arthralgia, urticaria pruritus, acute mastitis, furunculosis, scrofula, anal fistula, acute toothache, tinea capitis, honeybee stings swollen pain.Selecting Radix Pseudostellariae is that tepor, enters the heart, spleen, lung three warps, has the function of tonifying the lung, spleen invigorating, controls cough due to deficiency of the lung because of its nature and flavor sweetness and bitterness, insufficiency of the spleen lack of appetite, and cardiopalmus order antiperspirant, spirit is tired.Select Cortex Lycii to be because its nature and flavor are sweet, cold, enter lung, liver, kidney channel, there is heat clearing away, the function of removing heat from blood, controls asthenia hectic fever night sweat, and lung-heat cough with asthma is spitted blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Select Carapax et Plastrum Testudinis to be because its nature and flavor are salty sweet, flat, enter liver, kidney channel, there is YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the function of strong bone, controls deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.Select Rhizoma Zingiberis to be because its nature and flavor are pungent, heat, enters spleen, stomach, lung meridian, has warming middle-JIAO by cold, and the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomit and diarrhoea, and cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.Select Radix Gentianae to be because its nature and flavor are bitter, cold, enter liver, gallbladder meridian, there is eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Radix Curcumae to be because its nature and flavor are arduous, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, controls all pains of breast abdomen side of body rib, loses the heart demented, calentura coma, spits blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Selecting Ramulus Cinnamomi is that temperature, enters bladder, the heart, lung meridian, has diaphoresis expelling pathogenic factors from muscles because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Cornu Bubali to be because its nature and flavor hardship is salty, tremble with fear, have the function of heat clearing away, removing heat from blood, removing toxic substances, control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.Select Herba Portulacae Grandiflorae to be because its nature and flavor are bitter, cold, there is heat clearing away, the function of removing toxic substances, controls laryngopharynx swelling and pain, scalds traumatic injury, eczema.Select the Rhizoma Anemarrhenae to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, there is nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Folium Isatidis to be because its nature and flavor are bitter, cold, enter liver, the heart, stomach warp, there is heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Selecting Folium Bambusae is because its property slightly sweet flavor, cold, enters the heart, lung, gallbladder, stomach warp, has clearing heat and relieving fidgetness, and the function of the diuresis of promoting the production of body fluid controls that calentura is tired drinks, and little youngster shies Epilepsy, and cough with dyspnea is told nosebleed, flushed complexion, oliguria with reddish urine, erosion of the oral mucosa tongue boil.Select Bulbus Lilii to be because its property sweet and slightly bitter taste is flat, enter the heart, lung meridian, have nourishing the lung to arrest cough, the function of clearing away heart-fire for tranquillization, controls pulmonary tuberculosis chronic cough, cough and spit expectorant blood, and after calentura, waste heat is unclear, fidgets due to deficiency palpitation with fear, staring spells, beriberi edema.Select Flos Chrysanthemi Indici to be because its nature and flavor toil is cool, enter lung, Liver Channel, have wind and heat dispersing, the function of subduing swelling and detoxicating, controls anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters.Select Herba Schizonepetae to be because its nature and flavor are pungent, temperature, enters lung, Liver Channel, delivers, dispel the wind, and the function for the treatment of blood disorders, parch to black hemostasis, the heating that cures cold, headache, laryngopharynx swelling and pain, apoplexy locked mouth, spits blood, and epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.

The specific embodiment

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

5-15 gram of Caulis Lonicerae 5-15 gram of Rhizoma Curculiginis 5-15 Cray Tripterygium wilfordii

Fructus Tsaoko 15-25 gram of Fructus Mume 25-35 gram of Gekko Swinhonis 10-20 gram

Herba Taraxaci 10-20 gram of Radix Carpesii 10-20 gram of Talcum 10-20 gram

Medulla Junci 25-35 gram of Semen Celosiae 25-35 gram of Semen Cuscutae 25-35 gram

Semen Ziziphi Spinosae 5-15 gram of Carapax Trionycis 5-15 gram of Herba Dendrobii 5-15 gram

Nidus Vespae 15-25 gram of Radix Pseudostellariae 15-25 gram of Cortex Lycii 15-25 gram

Carapax et Plastrum Testudinis 10-20 gram of Rhizoma Zingiberis 10-20 cron gallbladder 10-20 gram

Radix Curcumae 15-25 gram of Ramulus Cinnamomi 15-25 gram of Cornu Bubali 15-25 gram

Herba Portulacae Grandiflorae 15-25 gram of Rhizoma Anemarrhenae 25-35 gram of Folium Isatidis 10-20 gram

Folium Bambusae 5-15 gram of Bulbus Lilii 5-15 gram of Flos Chrysanthemi Indici 5-15 gram

Herba Schizonepetae 10-20 gram

Preferable amount is

10 grams of 10 grams of Caulis Loniceraes of Rhizoma Curculiginis 10 Cray Tripterygium wilfordii

15 grams of 30 grams of Gekko Swinhonis of 20 grams of Fructus Mumes of Fructus Tsaoko

15 grams, 15 grams of Talcums of 15 grams of Radix Carpesiis of Herba Taraxaci

30 grams of 30 grams of Semen Cuscutae of 30 grams of Semen Celosiae of Medulla Junci

10 grams of 10 grams of Herba Dendrobiis of 10 grams of Carapax Trionycis of Semen Ziziphi Spinosae

20 grams of 20 grams of Cortex Lycii of 20 grams of Radix Pseudostellariaes of Nidus Vespae

15 grams, 15 grams of Rhizoma Zingiberiss of Carapax et Plastrum Testudinis, 15 cron gallbladder

20 grams of 20 grams of Cornu Bubalis of 20 grams of Ramulus Cinnamomi of Radix Curcumae

15 grams of 30 grams of Folium Isatidiss of 20 grams of Rhizoma Anemarrhenaes of Herba Portulacae Grandiflorae

10 grams of 10 grams of Flos Chrysanthemi Indicis of 10 grams of Bulbus Liliies of Folium Bambusae

15 grams of Herba Schizonepetae

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Rhizoma Curculiginis: get clean Rhizoma Curculiginis and mix thoroughly with yellow wine, after running through, put pot interior micro-stir-fry to dry, take out, dry, 100 jin of every Rhizoma Curculiginises, with 10-20 jin of yellow wine;

2, Radix Tripterygii Wilfordii: remove residual root bark, soak, clean, run through, cut sheet, dry, sieve removes chip;

3, Caulis Lonicerae: choose decontamination, be soaked in water, run through, section, dries;

4, Fructus Tsaoko: choose clean impurity, put pot interior slow fire and fry to shell coke yellow micro-heaving, take out slightly coolly, stone roller shells, and sieves and gets core;

5, Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;

6, Gekko Swinhonis: get crude drug, remove impurity;

7, Herba Taraxaci: choose decontamination, clean earth, cutting, dries;

8, Radix Carpesii: choose clean impurity, dry;

9, Talcum: get crude drug, remove impurity, cleaning, drying;

10, Medulla Junci: get Medulla Junci and put in pot, above cover the smaller pot of a bore, paste with blank sheet of paper, two pots of junctions, use brine sludge sealing, do not make to lose heart, is calcined to blank sheet of paper and is coke yellow truce, after cooling completely, takes out;

11, Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, removes impurity, dries;

12, Semen Cuscutae: sieve and remove impurity, clean, dry;

13, Semen Ziziphi Spinosae: former medicine is put into bamboo square-bottomed bamboo basket, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, and Semen Ziziphi Spinosae is pulled out, dries;

14, Carapax Trionycis: be soaked in water, remove skin and flesh, clean, dry;

15, Herba Dendrobii: get dry Herba Dendrobii, saturating with approximately to eighty per cant of blister, stewing profit, removes undesirable root and black branch, and cutting, hits thin film, dries;

16, Nidus Vespae: clean, steam thoroughly, decoct into fritter, dry;

17, Radix Pseudostellariae: extract fibrous root, dry;

18, Cortex Lycii: choose decontamination and core, slightly wash, cutting, dries;

19, Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, clean, dry knock fritter;

20, Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices after moistening or dice, dry;

21, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;

22, Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;

23, Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;

24, Cornu Bubali: rive, with hot-water soak, pull out, pound sheet, dries;

25, Herba Portulacae Grandiflorae: choose clean impurity, remove rhizome, dry;

26, the Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, softens, and section is dried;

27, Folium Isatidis: choose decontamination and dead leaf, clean, slightly moisten, cutting, dries;

28, Folium Bambusae: choose clean impurity, except destemming leaf, dry;

29, Bulbus Lilii: choose decontamination, black lobe, the ash disposal of winnowing with a dustpan bits;

30, Flos Chrysanthemi Indici: remove impurity, remove undesirable root, clean cutting, dry;

31, Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries.

Two, preparation

1, the Rhizoma Curculiginis of described weight, Radix Tripterygii Wilfordii, Caulis Lonicerae, Fructus Tsaoko, Fructus Mume, Gekko Swinhonis, Herba Taraxaci, Radix Carpesii, Talcum, Medulla Junci, Semen Celosiae, Semen Cuscutae, Semen Ziziphi Spinosae, Carapax Trionycis, Herba Dendrobii, Nidus Vespae, Radix Pseudostellariae, Cortex Lycii, Carapax et Plastrum Testudinis, Rhizoma Zingiberis, Radix Gentianae, Radix Curcumae, Ramulus Cinnamomi, Cornu Bubali, Herba Portulacae Grandiflorae, the Rhizoma Anemarrhenae, Folium Isatidis, Folium Bambusae, Bulbus Lilii, Flos Chrysanthemi Indici, Herba Schizonepetae medicine are decocted with water to secondary, add for the first time 8 times of amounts of water, soak after 100 minutes, intense fire decocts boiling 15 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time.

2, the medicinal residues of filtration are added to 6 times of amounts of water, first boil with high heat, then use slow fire boiling 40 minutes, filter to obtain decoction liquor for the second time.

3,, by twice decoction liquor mixing and stirring, be divided into 6 doses and take.

Medicine of the present invention has heat clearing away, hemostasis, and parasite killing, antiinflammatory, the effect of removing toxic substances, treatment Behcet disease instant effect, short treating period, do not recur.

By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 172 examples for medical treatment.

2, diagnostic criteria

Clinical manifestation

1. send out well crowd: this disease is found in all kinds of crowds of China, all can be ill from teenager to old man, the young and the middle aged is more common, and men and women all can fall ill.

2. oral ulcer: patient's main manifestations is oral ulcer, pain repeatedly, and ulcer surface is dark, bottom mostly is white or yellow, can occur that a plurality of ulcer (is commonly called as that " aphtha ") comprises tongue, lip, maxillary, pharyngeal etc. simultaneously at a plurality of positions.Most ulcer can take a turn for the better voluntarily, but Chang Fanfu outbreak, severe patient sharp ache, very impact feed.

3. genital ulcer: except oral ulcer, patient also can occur external genital ulcer, and as male and ulcers of female genital organs, the ulcer at these positions can be larger, can be single-shot.

4. eye pathological changes: some patients were also can show as eyes pathological changes, occurs inflamed eyes, pain, photophobia or visual deterioration, blurring of vision, can one or two eyes get involved.

5. cutaneous manifestations: also dermatosis appears in some patient, " " sample erythra, or be similar to the performance of " furuncle ", can take a turn for the better comedo voluntarily, but easily outbreak repeatedly to show as face, chest and back or other position.The patient who has in addition there will be that lower limb are blue, swelling and pain, can touch " pimple ", the patient's lower limb that also have there will be the erythema of outbreak repeatedly, not of uniform size, can be big or small from Semen Glycines size to copper coin, pain while pressing, this phenomenon is called " erythema nodosa ".The patient who also has there will be redness or vesicle or pustule in transfusion or blood drawing pinprick part, most appearance in 24～72 hours after injection, and this phenomenon is called as the " acupuncture reaction " positive.

6. arthropathy: many patients there will be arthralgia or swelling, can single or multiple joints, and joint of the lower extremity is common, can accompany arms and legs pain, and hydrarthrosis, synovitis appear in severe patient.

7. digestive tract pathological changes: the more common performance of another one is symptom of digestive tract, chest pain when comprising dysphagia or swallowing, return that acid is heartburn, have pus or blood in stomachache, diarrhoea, stool, or oneself touch abdominal part and have enclosed mass, weight loss, become thin, there is no appetite, these symptoms can all occur or only occur one of them, and the patient who did gastroscope or intestinal mirror can be apprised of " ulcer ".

8. vascular lesion: thrombophlebitis and deep venous thrombosis can appear in small part patient, severe patient can also pulmonary embolism, and patient can breathe hard, feel suffocated after appearance activity, and chest pain is even fainted.Can there is aneurysm in the patient who also has, cause local thromboembolism, ischemia, can massive hemorrhage, even threat to life after aneurysm rupture.

9. nervous system lesion: the patient who has can have one's fingers all thumbs, headache dizziness, nausea and vomiting, trick stolidity, pain or unable, also can there is the trick paralysis of a side, serious have a convulsion, show the whites of one's eyes etc. similar " take out epilepsy " performance, these are likely that Behcet disease has damage nervous system.The position that nervous system is the most often got involved is brain stem, is also found in spinal cord, cerebral hemisphere, cerebellum and meninges, can occur brain atrophy.

10. General Symptoms: many patients accompany weak, poor appetite, low grade fever and the General Symptoms such as become thin.

3, Therapeutic Method

Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 7 days was a course for the treatment of, took continuously 4 courses for the treatment of.

4, efficacy assessment standard

Effective: transference cure, it is normal that body constitution is recovered, and observes 1 year without recidivist;

Take a turn for the better: the state of an illness is clearly better, and body constitution is progressively recovered.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy Behcet disease patient of the present invention 172 examples, effective 163 examples of result, obvious effective rate is 94.77%, 7 examples that take a turn for the better, and improvement rate is 4.07%, invalid 2 examples, total effective rate is 98.84%.

Claims (3)

1. a medicine for the treatment of Behcet disease, is characterized in that: it is to be made by the crude drug in following weight range:

5-15 gram of Caulis Lonicerae 5-15 gram of Rhizoma Curculiginis 5-15 Cray Tripterygium wilfordii

Fructus Tsaoko 15-25 gram of Fructus Mume 25-35 gram of Gekko Swinhonis 10-20 gram

Herba Taraxaci 10-20 gram of Radix Carpesii 10-20 gram of Talcum 10-20 gram

Medulla Junci 25-35 gram of Semen Celosiae 25-35 gram of Semen Cuscutae 25-35 gram

Semen Ziziphi Spinosae 5-15 gram of Carapax Trionycis 5-15 gram of Herba Dendrobii 5-15 gram

Nidus Vespae 15-25 gram of Radix Pseudostellariae 15-25 gram of Cortex Lycii 15-25 gram

Carapax et Plastrum Testudinis 10-20 gram of Rhizoma Zingiberis 10-20 cron gallbladder 10-20 gram

Radix Curcumae 15-25 gram of Ramulus Cinnamomi 15-25 gram of Cornu Bubali 15-25 gram

Herba Portulacae Grandiflorae 15-25 gram of Rhizoma Anemarrhenae 25-35 gram of Folium Isatidis 10-20 gram

Folium Bambusae 5-15 gram of Bulbus Lilii 5-15 gram of Flos Chrysanthemi Indici 5-15 gram

Herba Schizonepetae 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

10 grams of 10 grams of Caulis Loniceraes of Rhizoma Curculiginis 10 Cray Tripterygium wilfordii

15 grams of 30 grams of Gekko Swinhonis of 20 grams of Fructus Mumes of Fructus Tsaoko

15 grams, 15 grams of Talcums of 15 grams of Radix Carpesiis of Herba Taraxaci

30 grams of 30 grams of Semen Cuscutae of 30 grams of Semen Celosiae of Medulla Junci

10 grams of 10 grams of Herba Dendrobiis of 10 grams of Carapax Trionycis of Semen Ziziphi Spinosae

20 grams of 20 grams of Cortex Lycii of 20 grams of Radix Pseudostellariaes of Nidus Vespae

15 grams, 15 grams of Rhizoma Zingiberiss of Carapax et Plastrum Testudinis, 15 cron gallbladder

20 grams of 20 grams of Cornu Bubalis of 20 grams of Ramulus Cinnamomi of Radix Curcumae

15 grams of 30 grams of Folium Isatidiss of 20 grams of Rhizoma Anemarrhenaes of Herba Portulacae Grandiflorae

10 grams of 10 grams of Flos Chrysanthemi Indicis of 10 grams of Bulbus Liliies of Folium Bambusae

15 grams of Herba Schizonepetae.

3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Rhizoma Curculiginis: get clean Rhizoma Curculiginis and mix thoroughly with yellow wine, after running through, put pot interior micro-stir-fry to dry, take out, dry, 100 jin of every Rhizoma Curculiginises, with 10-20 jin of yellow wine;

(2) Radix Tripterygii Wilfordii: remove residual root bark, soak, clean, run through, cut sheet, dry, sieve removes chip;

(3) Caulis Lonicerae: choose decontamination, be soaked in water, run through, section, dries;

(4) Fructus Tsaoko: choose clean impurity, put pot interior slow fire and fry to shell coke yellow micro-heaving, take out slightly coolly, stone roller shells, and sieves and gets core;

(5) Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;

(6) Gekko Swinhonis: get crude drug, remove impurity;

(7) Herba Taraxaci: choose decontamination, clean earth, cutting, dries;

(8) Radix Carpesii: choose clean impurity, dry;

(9) Talcum: get crude drug, remove impurity, cleaning, drying;

(10) Medulla Junci: get Medulla Junci and put in pot, above cover the smaller pot of a bore, paste with blank sheet of paper, two pots of junctions, use brine sludge sealing, do not make to lose heart, is calcined to blank sheet of paper and is coke yellow truce, after cooling completely, takes out;

(11) Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, removes impurity, dries;

(12) Semen Cuscutae: sieve and remove impurity, clean, dry;

(13) Semen Ziziphi Spinosae: former medicine is put into bamboo square-bottomed bamboo basket, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, and Semen Ziziphi Spinosae is pulled out, dries;

(14) Carapax Trionycis: be soaked in water, remove skin and flesh, clean, dry;

(15) Herba Dendrobii: get dry Herba Dendrobii, saturating with approximately to eighty per cant of blister, stewing profit, removes undesirable root and black branch, and cutting, hits thin film, dries;

(16) Nidus Vespae: clean, steam thoroughly, decoct into fritter, dry;

(17) Radix Pseudostellariae: extract fibrous root, dry;

(18) Cortex Lycii: choose decontamination and core, slightly wash, cutting, dries;

(19) Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, clean, dry knock fritter;

(20) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices after moistening or dice, dry;

(21) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;

(22) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;

(23) Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;

(24) Cornu Bubali: rive, with hot-water soak, pull out, pound sheet, dries;

(25) Herba Portulacae Grandiflorae: choose clean impurity, remove rhizome, dry;

(26) Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, softens, and section is dried;

(27) Folium Isatidis: choose decontamination and dead leaf, clean, slightly moisten, cutting, dries;

(28) Folium Bambusae: choose clean impurity, except destemming leaf, dry;

(29) Bulbus Lilii: choose decontamination, black lobe, the ash disposal of winnowing with a dustpan bits;

(30) Flos Chrysanthemi Indici: remove impurity, remove undesirable root, clean cutting, dry;

(31) Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;

(2) preparation

(1) Rhizoma Curculiginis of described weight, Radix Tripterygii Wilfordii, Caulis Lonicerae, Fructus Tsaoko, Fructus Mume, Gekko Swinhonis, Herba Taraxaci, Radix Carpesii, Talcum, Medulla Junci, Semen Celosiae, Semen Cuscutae, Semen Ziziphi Spinosae, Carapax Trionycis, Herba Dendrobii, Nidus Vespae, Radix Pseudostellariae, Cortex Lycii, Carapax et Plastrum Testudinis, Rhizoma Zingiberis, Radix Gentianae, Radix Curcumae, Ramulus Cinnamomi, Cornu Bubali, Herba Portulacae Grandiflorae, the Rhizoma Anemarrhenae, Folium Isatidis, Folium Bambusae, Bulbus Lilii, Flos Chrysanthemi Indici, Herba Schizonepetae medicine are decocted with water to secondary, add for the first time 8 times of amounts of water, soak after 100 minutes, intense fire decocts boiling 15 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time;

(2) medicinal residues of filtration are added to 6 times of amounts of water, first boil with high heat, then use slow fire boiling 40 minutes, filter to obtain decoction liquor for the second time;

(3), by twice decoction liquor mixing and stirring, be divided into 6 doses and take.