CN102657773B - Medicament for treating appendicitis and preparation method thereof - Google Patents

Medicament for treating appendicitis and preparation method thereof Download PDF

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CN102657773B
CN102657773B CN 201210178641 CN201210178641A CN102657773B CN 102657773 B CN102657773 B CN 102657773B CN 201210178641 CN201210178641 CN 201210178641 CN 201210178641 A CN201210178641 A CN 201210178641A CN 102657773 B CN102657773 B CN 102657773B
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王光华
王萍
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王光华
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Abstract

本发明公开了一种治疗阑尾炎的药物及其制备方法,它主要是由牡丹皮、生地黄、金银花、枳实、土元、甘草、败酱按一定重量配比制备而成,本发明药物具有活血化瘀,清热解毒,散痈消积的功能,用于治疗阑尾炎疗效好,见效快,治愈率高。 The present invention discloses a pharmaceutical preparation and a method of treating appendicitis, is mainly composed of Cortex Moutan, Radix Rehmanniae, honeysuckle, citrus aurantium, earth element, licorice, Patrinia prepared from certain weight ratios, the pharmaceutical of the present invention having blood circulation, detoxify, loose consumer product functions carbuncle, appendicitis good efficacy for the treatment, quick, high cure rate.

Description

一种治疗阑尾炎的药物及其制备方法 A pharmaceutical preparation and method of treatment of appendicitis

技术领域 FIELD

[0001] 本发明涉及一种治疗阑尾炎的药物及其制备方法,属中药领域。 [0001] The present invention relates to a pharmaceutical preparation and a method of treating appendicitis, it belongs to the field of medicine.

背景技术 Background technique

[0002] 阑尾炎是一种常见的多发病,临床上常有右下腹部疼痛、体温升高、呕吐和中性粒细胞增多等表现。 [0002] appendicitis is a common disease, clinically often right lower abdominal pain, fever, vomiting and other symptoms increase in neutrophils. 急性阑尾炎的典型临床表现是逐渐发生的上腹部或脐周围隐痛,数小时后腹痛转移至右下腹部。 Typical clinical manifestations of acute appendicitis is abdominal pain around the navel or occurs gradually, abdominal pain a few hours later transferred to the lower right abdomen. 常伴有食欲不振、恶心或呕吐,发病初期除低热、乏力外,多无明显的全身症状。 Often accompanied by loss of appetite, nausea or vomiting, in addition to the early onset of fever, fatigue, and more without obvious symptoms. 急性阑尾炎若不早期治疗,可以发展为阑尾坏疽及穿孔,并发局限或弥漫性腹膜炎。 Without early treatment of acute appendicitis, the appendix can be developed into gangrene and perforation, complicated by limited or diffuse peritonitis. 如果延误诊断和治疗可引起严重的并发症,甚至造成死亡。 If the delay in diagnosis and treatment can lead to serious complications and even death.

[0003] 绝大多数急性阑尾炎一旦确诊,都施行阑尾切除术,但手术风险大,费用高,还易引发并发症,且服用西药抗生素副作用影响较大。 [0003] The vast majority once diagnosed acute appendicitis, appendectomy are implemented, but the surgical risk, high cost, but also easily lead to complications and side effects of taking the medicine antibiotic greater impact.

发明内容 SUMMARY

[0004] 因此人们对疗效较好的中药存在极大的需求,至今为止目前还没有发现关于本发明药物的有关报道。 [0004] Therefore there is a great need for people to better efficacy of traditional Chinese medicine, so far we have not found the reports on drug invention. 本发明人依据中医理论的研究及临床反复的试验和验证,终于找到了速效治疗阑尾炎的药物,从而完成了本发明。 The present inventors have repeated based on research and clinical trials and validation of traditional Chinese medicine theory, finally found a medication available for appendicitis, and thus completed the present invention.

[0005] 本发明的目的就是提供一种疗效显著、服用方便、无毒副作用的治疗阑尾炎的中药组合物。 [0005] The object of the present invention is to provide a significant effect, easy to take, the toxic side effects of the treatment of appendicitis herbal composition.

[0006] 发明的另一个目的就是提供了该组合药物的制备方法。 Another object of the [0006] invention is to provide a method for the preparation of pharmaceutical compositions.

[0007] 本发明药物是选择牡丹皮、知母、白芷、生地黄、木香、柴胡、金银花、枳实、土元(异名土鳖虫)、桃仁、白芍、鸡内金、茶叶、乌梅、大黄、甘草、败酱进行组合的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗阑尾炎的复发。 Drug [0007] The present invention is selected tree peony bark, Anemarrhena, Angelica, Radix Rehmanniae, woody, Bupleurum, honeysuckle, citrus aurantium, earth element (synonym Eupolyphaga), peach kernel, white peony root, Gallus gallus, tea, ebony, rhubarb, licorice, Patrinia are combined, so that each of these pharmaceutical compositions the synergistic effect of drug efficacy, it is possible to effectively treat recurrent of appendicitis. 其中选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。 Where the choice of Paeonia because of its taste hard, cold, into the heart, liver, kidney, there is heat, cooling blood, and blood, Xiaoyu function, treatment of heat into the blood, hair patches, scared epilepsy, spit, bleed at the nose , blood in the stool, Gu Zheng labor hot, amenorrhea, Zheng Jia, carbuncle ulcers, flapping loss. 选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。 Selection altogether because of their sexual bitter, cold, lung, stomach, kidney, there is nourishing Yin, moistening Hua Chang function, Fanre diabetes treatment, Gu Zheng labor heat, Hyperactivity cough, dry stool knot, difficult urination. 选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。 Angelica chosen because of its spicy, warm, lungs, spleen, stomach, expelling wind, dampness, swelling, pain in the function, headache, Mei Leng bone pain, tooth pain, Bi Yuan, cold abdominal pain , intestinal wind anal fistula, vaginal discharge, ulcer sore, itchy dry skin, scabies. 选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。 Selection REHMANNIAE because of its sweet, cold, heart, liver, kidney, there is heat and cooling blood, Yin, Sheng Jin function, cure fever, thirst, deficiency heat, Gu Zheng labor heat, heat diabetes, hematemesis, hair spot rash. 选用木香是因为其性味辛苦、温。 Selected because of its woody taste hard, warm. 入肺、肝、脾经。 Lungs, liver, spleen. 行气止痛,温中和胃。 Gas pain, temperature and stomach. 治中寒气滞,胸腹胀痛,呕吐,泄泻,下痢里急后重,寒疝。 Governance in cold stagnation, abdominal pain, vomiting, diarrhea, tenesmus, diarrhea, Han Shan. 选用柴胡是因为其性味苦,微寒,归肝、胆经。 Bupleurum is chosen because of their sexual bitter, slightly cold, the liver, gall bladder. 和解少阳,退热疏肝,升阳。 Reconciliation Shaoyang, fever liver, Sun Microsystems. 用于感冒发热,寒热往来,胸胁胀痛,月经不调,子宫脱垂,脱肛。 For colds, fever, chills and fever, chest pain, irregular menstruation, uterine prolapse, rectal prolapse. 选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。 Honeysuckle is chosen because of its sweet, cold, lung, stomach, there are detoxification function, treatment of febrile disease, fever, hot sera dysentery, carbuncle ulcers, swollen poison, scrofulous, anal fistula. 选用枳实是因为其性味苦,寒,入脾、胃经,有破气,散痞,泻痰,消积的功能,治胸腹胀痛,胸痹,痞痛,痰癖,水肿,食积,便秘,胃下垂,子宫下垂,脱肛。 Citrus aurantium is chosen because it is of bitter, cold, spleen, stomach, have broken gas, loose swelling of the liver, diarrhea sputum, consumer product function, treatment abdominal pain, Chest, swelling of the liver pain, addiction sputum, edema, dyspepsia , constipation, gastroptosis, uterine prolapse, rectal prolapse. 选用土元是因为其性味咸、寒,有小毒。 Earth element is chosen because of its taste salty, cold, a small drug. 归肝经。 Owned by the liver. 破瘀血,续筋骨。 Broken blood stasis, continued bones. 用于筋骨折伤,瘀血经闭,癥瘕痞块。 Injury to bones off, bleeding amenorrhea, Zhengjia lump. 选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。 Selected because of its peach kernel of bitter sweet, flat, into the heart, liver, large intestine, have broken blood stasis, moistening slip through the function, treat amenorrhea, Zheng Jia, Xuxue fever, blood paralysis, malaria, down fight damage, bleeding throat, dryness constipation. 选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。 Selected because of its peony of bitter acid, cold, liver, spleen, nourishing liver, the pain relief, the female received convergence function Khan, treat abdominal flank pain, abdominal pain and dysentery, spontaneous sweating , Yin fever, irregular menstruation, uterine bleeding, vaginal discharge. 选用鸡内金是因为其性味甘,平,入脾、胃经,有治积滞,健脾胃的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。 Gallus gallus chosen because of its sweet, flat, spleen, stomach, there Indigestion rule, the function of spleen and stomach, cure food product fullness, nausea and vomiting, dysentery, malnutrition, diabetes, left drowning, throat Bi milk moth, Yagan mouth sores. 选用茶叶是因为其性味苦甘、凉。 Tea is chosen because of their sexual bitter sweet, cool. 入心、肺、胃经。 Into the heart, lung and stomach. 清头目,除烦渴,化痰,消食,利尿,解毒。 Clear leader, with the exception polydipsia, phlegm, digestion, diuretic, detoxifying. 治头痛,目昏,多睡善寐,心烦口渴,食积痰滞,疟,痢。 Headache, head faint, good sleep soundly, upset thirst, food product phlegm stagnation, malaria, dysentery. 选用乌梅是因为其性味酸,温,入肝,脾,肺,大肠经,有收敛生津,安蛔驱虫的功能,治久咳,虚热烦渴,久疟,痢疾,便血,尿血,血崩,蛔厥腹痛,呕吐,钩虫病,牛皮癣,胬肉。 Ebony choice because of its Pickle, warm, liver, spleen, lung, large intestine, there is convergence Sheng Jin, An roundworm worming functions, governance cough and Hot thirst, long malaria, diarrhea, blood in the stool, hematuria, vaginal bleeding , roundworm Jue abdominal pain, vomiting, hookworm disease, psoriasis, pterygium. 选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。 Rhubarb is chosen because of their sexual bitter, cold, stomach, large intestine, liver diameter, have spilled toxic heat, break stagnation, blood stasis row of function, excess heat cure constipation, delirium mad, food product fullness, dysentery early, tenesmus, stop stasis amenorrhea, Zheng Jia accumulation, when the line Fever, bug-eyed red pain, vomiting, epistaxis, sun yellow, edema, pouring muddy, steep red, swollen poison carbuncle ulcers, boils, soup burns. 选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心t季,惊痈,生用治咽喉肿痛,消化性溃瘍,痈疽疮瘍,解药毒及食物中毒。 Licorice is chosen because of its sweet, Rupi, stomach, lung, and there are priorities, lungs, detoxification, to reconcile the function of various drugs, Sunburn treatment weak stomach, eat less, loose stools, abdominal pain, fever weary, Fei Wei cough, heart t season, scared carbuncle, born with a cure sore throat, peptic ulcer, ulcer sore, antidote to poison and food poisoning. 选用败酱是因为其性味辛,苦,凉。 Patrina chosen because of its spicy, bitter, cold. 归胃、大肠、肝经。 Owned by the stomach, large intestine, liver. 清热解毒,祛瘀排脓。 Detoxification, blood stasis and drainage. 用于阑尾炎,痢疾,肠炎,肝炎,眼结膜炎,产后瘀血腹痛,痈肿疔疮。 For appendicitis, dysentery, enteritis, hepatitis, conjunctivitis, postpartum bleeding, abdominal pain, carbuncle swollen boils.

[0008] 本发明组合药物的用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好疗效: Al. [0008] The amount of the pharmaceutical composition of the present invention is summarized inventors have obtained a lot of exploration, the ratio of components in the following weight range have good effect:

[0009] 牡丹皮10 — 20克知母12 — 20克白芷10 — 20克 [0009] Paeonia 10--20 g of Anemarrhena 12--20 g of Angelica 10--20 g of

[0010] 生地黄10 — 20克木香10 — 20克柴胡10 — 20克 [0010] Rehmanniae 10--20 g of wood 10--20 g of Bupleurum 10--20 g of

[0011] 金银花25— 35克枳实10 —15克土元10 —15克 [0011] Citrus aurantium honeysuckle 25-35 g 10-15 g 10-15 g earth element

[0012] 桃仁10—12克白芍5—12克鸡内金8—15克 [0012] 10-12 g of white peony 5-12 grams walnuts Gallus gallus 8-15 g

[0013] 茶叶5—12克乌梅8—12克大黄8—15克 [0013] Kewu Mei tea 5-12 8-12 8-15 grams grams of rhubarb

[0014] 甘草5—8克败酱90 —110克 [0014] 5-8 g of licorice Patrinia 90-110 g

[0015] 其中,优选为 [0015] wherein, preferably

[0016] 牡丹皮15克 知母15克白芷15克 [0016] Paeonia Angelica 15 g 15 g 15 g Zhimu

[0017] 生地黄15克 木香15克柴胡 15克 [0017] Rehmanniae Bupleurum 15 g 15 g 15 g wood

[0018] 金银花30克 枳实12克土元12克 [0018] 30 grams of honeysuckle citrus aurantium 12 grams 12 grams earth element

[0019] 桃仁10克 白芍10克鸡内金10克 [0019] 10 grams walnuts peony 10 grams 10 grams of Gallus gallus domesticus

[0020] 茶叶10克 乌梅9克大黄10克 [0020] 10 g of tea ebony 9 grams 10 grams of rhubarb

[0021] 甘草6克 败酱100克 [0021] 6 grams of licorice Patrinia 100 g

[0022] 本发明药物的制备方法如下 Preparation [0022] The method of the present invention as medicament

[0023] 一、备料 [0023] First, preparation

[0024] 1、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干; [0024] 1, moutan: pick impurities, removing the heart wood, washed, run through, sliced, dried;

[0025] 2、知母:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥; [0025] 2, Anemarrhena: pick impurities, the size of a separated, thoroughly soaked with water to eighty percent, fish, drying in the sun, to run a uniform internal and external moisture, sliced, and dried;

[0026] 3、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润,切片干燥; [0026] 3, Angelica: sorting net impurity, washed with water, soaking, remove run through, the skin without sun to slightly greasy feel, and then moistening, drying sections;

[0027] 4、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑; [0027] 4, Rehmannia: taking raw herbs to remove impurities, washing, little run, cut into thick slices, and dried, to screen debris;

[0028] 5、木香:将原生药放清水内洗净,捞出,闷润12-24小时使软,切片,晒干;[0029] 6、柴胡:取原药材,除去残茎,杂质,洗净,润软,切厚片,干燥,筛去碎屑; [0028] 5, woody: the original crude drug release washed with water, remove, moistening 12-24 hours to make soft, sliced, dried; [0029] 6, Bupleurum: taking raw herbs to remove residual stems, impurities, washed, run soft, cut into thick slices, and dried, to screen debris;

[0030] 7、金银花:筛去泥沙,拣净杂质; [0030] 7, honeysuckle: sieve to the sediment, sorting net impurity;

[0031] 8、枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干; [0031] 8, citrus aurantium: sorting net impurities, to eighty percent water immersion lens, remove, run into the heart no hard, sliced, dry;

[0032] 9、土元:取原药材,洗净,干燥; [0032] 9, earth element: taking raw herbs, washed, and dried;

[0033] 10、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净; [0033] 10, peach: hard to remove impurities, boiling water pot boil rugulose skin, remove, immersed in cold water, to rub the seed coat, dry, toss the net;

[0034] 11、白苟:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥; [0034] 11, white Gou: pick impurities, the size of a separated, thoroughly soaked with water to eighty percent, fish, drying in the sun, to run a uniform internal and external moisture, sliced, and dried;

[0035] 12、鸡内金:拣去杂质,漂净晒干; [0035] 12, Gallus gallus: pick impurities, rinse and dried;

[0036] 13、茶叶:取原药材,除去杂质、枝梗; [0036] 13, Tea: taking raw herbs to remove impurities, panicle;

[0037] 14、乌梅:拣净杂质,筛去灰屑,洗净,晒干; [0037] 14, ebony: sorting net impurity, screening out the gray debris, washed and dried;

[0038] 15、大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干; [0038] 15, rhubarb: sorting net impurities, the size of the sub-file, to run inside and outside humidity uniformly stew, sliced ​​or cut into small pieces and dried;

[0039] 16、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干; [0039] 16, licorice: pick impurities, washed, soaked in water to Bacheng thoroughly, remove, run through sliced, dried;

[0040] 17、败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥。 [0040] 17, Patrinia: taking raw herbs to remove impurities, is sprayed with water, a little dry, cut, and dried.

[0041] 二、制备 [0041] Second, the preparation of

[0042] 1、将所述重量的牡丹皮、知母、白芷、生地黄、木香、柴胡、金银花、枳实、土元、桃仁、白芍、鸡内金、绿茶、乌梅、大黄、甘草、败酱放入药锅内,加入清水3倍量浸泡2小时,用武火煎煮沸腾,再用文火煎煮10分钟,过滤得第一次煎煮液。 [0042] 1, the weight of Cortex Moutan, Anemarrhena, Angelica, Radix Rehmanniae, woody, Bupleurum, honeysuckle, citrus aurantium, earth element, peach, peony, Gallus gallus, green, plum, rhubarb, licorice, Patrinia drug into the pot, was added 3-fold amount of water soak 2 hours, Wuhuo boiling boiling, and then slow fire boiling for 10 minutes, filtered to obtain the first boiling liquid.

[0043] 2、将第一次过滤的药液倒出,再加清水3倍量,用武火煎煮沸腾,再用文火煎煮10分钟,过滤得二次煎煮液。 [0043] 2, the first filtration liquid was decanted, plus 3 times the amount of water, boiling with high heat boil, then simmer boiling for 10 minutes and filtered to give the secondary decoction.

[0044] 3、将二次煎煮药液合并,加热服用。 [0044] 3, the secondary boiling liquid were combined and heated administration. 第一次服用时将第二次煎煮药液合并于第一次煎煮液中混合均匀,再倒出500毫升服用,第二次服用时,将药液放在火上加热即可服用。 Taking the first second to the first combined boiling liquid decoction mixed, taking 500 ml decanted, taking the second time, the liquid can be heated to take over the fire.

[0045] 本发明药物具有消肿止痛,活血化瘀,行气凉血,清热解毒,散痈消积的功效,用于治疗阑尾炎见效快,治愈率高。 Drug invention [0045] This reduction of swelling and pain, blood circulation, cooling gas, detoxification, carbuncle bulk consumer product efficacy for the treatment of appendicitis quick, high cure rate.

具体实施方式 detailed description

[0046] 以下通过试验例来进一步阐述本发明药物的有益效果,这些试验例包括动物毒性试验和临床观察试验的报告。 [0046] The following is further illustrated by test agents of the invention advantageous effects, these test examples include animal toxicity testing and clinical observation test report.

[0047][试验例I]本发明药物的动物毒性试验报告: [0047] [Experimental Example I] of the present invention, the pharmaceutical animal toxicity test report:

[0048] 取西德兔40只,雌雄兼用,体重2.0—2.5kg,分两组,每组20只,其中一组为超剂量试验组,另一组为正常量试验组。 [0048] Take 40 West rabbits of either sex, body weight 2.0-2.5kg, divided into two groups, 20 in each group, one dose of test group over the group, the other group of the normal amount of the test group. 超常量组为30ml/kg,正常量为15ml/kg,给药方式为将药物稀释后,采用灌胃法给药,每天二次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。 Supernormal group was 30ml / kg, the normal amount of 15ml / kg, will be diluted after administration of the drug using oral gavage administration, twice a day for 7 days to observe the reaction is administered per day, the results show that the two groups rabbits activity, normal diet, drugs without adverse side effects.

[0049][试验例2]本发明药物的临床观察资料: [0049] [Test Example 2] Clinical medicament of the present invention observations:

[0050] 1、一般资料: [0050] 1, General Information:

[0051] 收治门诊患者350例,年龄35—40岁100例,41—50岁120例,50— 70例130例。 [0051] 350 cases treated outpatients, aged 35-40 years 100 cases, 120 cases 41-50, 50-70 Example 130 cases.

[0052] 2、诊断标准: [0052] 2, the diagnostic criteria:

[0053] 轻型类阑尾炎:发病初起,患者右下腹疼痛,食欲不振,低热乏力,恶心或呕吐。 [0053] Light appendicitis categories: early onset, in patients with right lower abdominal pain, loss of appetite, fatigue, fever, nausea or vomiting. [0054] 重型类阑尾炎:上腹部或脐周围隐痛,数小时后腹痛转移于右下腹部,并伴有食欲不振、恶心或呕吐症状。 [0054] Heavy duty appendicitis: the upper abdomen or around the navel pain, abdominal pain a few hours later transferred to the right lower abdomen, accompanied by loss of appetite, nausea or vomiting.

[0055] 3、治疗方法: [0055] 3, treatment:

[0056] 口服:每日早晚各一次,每次500毫升。 [0056] Oral: daily morning and evening, each 500 ml. 饭前用温开水冲服。 Before meals with warm boiled water. 服药期间,患者应忌食生、寒、油腻的食物。 During medication, patients should not eat raw, cold, greasy food. 轻型1-3日,重型4-5日痊愈。 Light 1-3 days, 4-5 days of heavy recovery.

[0057] 4、疗效评定标准: [0057] 4. The evaluation standard:

[0058] 显效:轻重型类阑尾炎经治疗后,患者腹痛症状消失,病人体质恢复正常。 [0058] Effect: light and heavy like appendicitis After treatment, patients with abdominal pain disappeared, the patient returned to normal physique. 随访I一10年无人复发。 I a 10 years of follow-up no recurrence.

[0059] 好转:患者症状逐步减轻,疼痛消失,感觉良好,体质基本恢复正常。 [0059] Improvement: symptoms gradually reduced, the pain disappeared, feel good, body returned to normal.

[0060] 无效:达不到好转标准者。 [0060] is invalid: not meet those standards improved.

[0061] 5、治疗结果 [0061] 5, treatment outcome

Figure CN102657773BD00071

[0063] 在1-3日的治疗中,用本发明药物治疗轻型阑尾炎患者215例,显效206例,好转9例,总有效率100% ;在4-5日的治疗中,用本发明药物治疗重型阑尾炎患者135例,显效90例,好转43例,总有效率98.50%。 [0063] In the treatment of 1-3 days, the treatment with the drug of the present invention, 215 cases of patients with appendicitis light, 206 cases were cured, improved in 9 cases, the total efficiency of 100%; in the treatment of 4-5, with the present invention is a pharmaceutical treatment of severe patients with appendicitis 135 cases, effective in 90 cases, improved in 43 cases, the total efficiency of 98.50%.

Claims (3)

  1. 1.一种治疗阑尾炎的药物,其特征在于:它是由下列重量范围内的原料药制成: 牡丹皮10 — 20克知母12 — 20克白芷10 — 20克生地黄10 — 20克木香10 — 20克柴胡10 — 20克金银花25— 35克枳实10 —15克土元10 —15克桃仁10 —12克白芍5 —12克鸡内金8 —15克茶叶5 —12克乌梅8 —12克大黄8 —15克甘草5— 8克败酱90 —110克。 1. A method of treating a pharmaceutical appendicitis, characterized in that: it is made of a drug within the following weight ranges: Moutan 10--20 g of Anemarrhena 12--20 g of Angelica 10--20 g of Rehmanniae 10--20, wood Hong 10--20 grams of Bupleurum 10--20 grams of honeysuckle 25-35 grams 10-15 grams of citrus aurantium earth element 10-15 grams of walnuts 10-12 grams of white peony root 5-12 grams of Gallus gallus 8-15 5-12 grams of tea Kewu Mei 8-12 g of rhubarb 8-15 grams of licorice 5-8 g Patrinia 90-110 g.
  2. 2.根据权利要求1所述的药物,其中各原料药的用量为: 牡丹皮15克知母15克白芷15克生地黄15克木香15克柴胡15克金银花30克枳实12克土元12克桃仁10克白芍10克鸡内金10克茶叶10克乌梅9克大黄10克甘草6克败酱100克。 2. A medicament according to claim 1, wherein the amount of each drug was: 15 g moutan Zhimu Angelica 15 g 15 g 15 g wood Rehmanniae 15 grams 15 grams 30 grams of honeysuckle Bupleurum citrus aurantium 12 g of soil element 12 grams walnuts 10 g 10 g white peony nutrition with 10 grams of tea 10 Kewu Mei 9 grams 10 grams 6 grams of licorice rhubarb Patrinia 100 grams.
  3. 3.如权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料(1)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干; (2)知母:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;` (3)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润,切片干燥; (4)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑; (5)木香:将原生药放清水内洗净,捞出,闷润12-24小时使软,切片,晒干; (6)柴胡:取原药材,除去残茎,杂质,洗净,润软,切厚片,干燥,筛去碎屑; (7)金银花:筛去泥沙,拣净杂质; (8)枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干; (9) 土元:取原药材,洗净,干燥; (10)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水 1 2 or 3. The pharmaceutical preparation of claim 1, which comprises the steps of: (a) preparation (1) of Cortex Moutan: pick impurities, removing the heart wood, washed, run through, sliced, dried; ( 2) altogether: pick impurities, the size of a separated, thoroughly soaked with water to eighty percent, fish, drying in the sun, to run a uniform internal and external moisture, slicing, drying; `(3) Angelica: sorting net impurity, washed with water, soaked , remove run through, the skin without sun to slightly greasy feel, moistening and then, sections were dried; (4) Rehmanniae: taking raw herbs to remove impurities, washing, little run, cut into thick slices, dried, crushed to the sieve debris; (5) wood: the original crude drug release washed with water, remove, moistening 12-24 hours to make soft, sliced, dried; (6) Bupleurum: taking raw herbs, stems remove residual impurities, washed, run soft, cut into thick slices, and dried, to screen debris; (7) honeysuckle: filtering out sediment, sorting net impurity; (8) Citrus aurantium: sorting net impurities, to eighty percent water immersion lens, remove, Run into the heart no hard, sliced, dried; (9) earth element: taking raw herbs, washed, and dried; (10) peach: hard to remove impurities, boiling water pot boil rugulose skin, remove, immersed in cold water 中,搓去种皮,晒干,簸净; (11)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥; (12)鸡内金:拣去杂质,漂净晒干; (13)茶叶:取原药材,除去杂质、枝梗; (14)乌梅:拣净杂质,筛去灰屑,洗净,晒干; (15)大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干; (16)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干; (17)败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥; (二)制备(I)将所述重量的牡丹皮、知母、白芷、生地黄、木香、柴胡、金银花、枳实、土元、桃仁、白芍、鸡内金、茶叶、乌梅、大黄、甘草、败酱放入药锅内,加入清水3倍量浸泡2小时,用武火煎煮沸腾,再用文火煎煮10分钟,过滤得第一次煎煮液; (2)将第一次过滤的药液倒出,再加清 , The seed coat to rubbing, dried, toss the net; (11) TGP: pick impurities, the size of a separated, thoroughly soaked with water to eighty percent, fish, drying in the sun, to run a uniform internal and external moisture, slicing, drying; ( 12) Gallus gallus: pick impurities, rinse and dried; (13) Tea: taking raw herbs to remove impurities, rachis; (14) ebony: sorting net impurity, screening out the gray debris, washed and dried; (15) rhubarb: sorting net impurities, the size of the sub-file, to run inside and outside humidity uniformly stew, sliced ​​or cut into small pieces and dried; (16) licorice: when pick impurities, washed, soaked in water to thoroughly eighty percent, fishing off, run through sliced, dried; (17) Patrinia: taking raw herbs to remove impurities, is sprayed with water, a little dry, cut into sections, dried; (ii) preparation of (I) the weight of moutan, known mother, Angelica, traditional Chinese medicine, wood, Radix, honeysuckle, citrus aurantium, earth element, peach, white peony root, Gallus gallus, tea, plum, rhubarb, licorice, Patrina drugs into the pot, add water 3 times an amount of 2 hours of soaking Wuhuo boiling boiling, and then slow fire boiling for 10 minutes, filtered to obtain the first boiling fluid; (2) the first filtration liquid was decanted, plus clear 3倍量,用武火煎煮沸腾,再用文火煎煮10分钟,过滤得二次煎煮液; (3)将二次煎煮药液合并,加热服用,`每次服用500克。 3 times the amount, Wuhuo boiling boiling, and then slow fire boiling for 10 minutes and filtered to give the secondary decoction; (3) the secondary boiling liquid were combined and heated to take, `each taking 500 grams.
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