CN102657773B - Medicament for treating appendicitis and preparation method thereof - Google Patents

Medicament for treating appendicitis and preparation method thereof Download PDF

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CN102657773B
CN102657773B CN201210178641.7A CN201210178641A CN102657773B CN 102657773 B CN102657773 B CN 102657773B CN 201210178641 A CN201210178641 A CN 201210178641A CN 102657773 B CN102657773 B CN 102657773B
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王光华
王萍
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王光华
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Abstract

The invention discloses a medicament for treating appendicitis and a preparation method thereof. The medicament is mainly prepared from moutan bark, dried rehamnnia root, honeysuckle, immature citron fruit, dried body of ground beetle, liquorice and Patrinia scaniosaefolia according to a certain weight proportion. The medicament disclosed by the invention has the functions of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, and dispersing carbuncle to removing stagnation, and has the advantages of good curative effect, quick acting and high cure rate for appendicitis.

Description

One is treated typhlitic medicine and preparation method thereof
Technical field
The present invention relates to one and treat typhlitic medicine and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Appendicitis is a kind of common frequently-occurring disease, often has clinically the performances such as right lower abdomen pain, fervescence, vomiting and neutrophilic leukocytosis.The typical clinical performance of acute appendicitis is epigastrium or the umbilicus dull pain around occurring gradually, and after a few hours, stomachache is transferred to right lower abdomen.Often with inappetence, n or V, their early stage except low grade fever, weak, many without obvious General Symptoms.If acute appendicitis is early treatment not, can develop into vermiform appendix gangrene and perforation, concurrent limitation or diffuse peritonitis.If delay diagnosis and treatment can cause serious complication, even cause death.
Once most acute appendicitiss are made a definite diagnosis, and all implement appendectomy, but operation risk are large, expense is high, also easily causes complication, and it is larger to take the impact of Western medicine antibiotic side effect.
Summary of the invention
Therefore there is great demand to the good Chinese medicine of curative effect in people, also do not find up to now the relevant report about medicine of the present invention at present.The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the typhlitic medicine of quick curing, thereby has completed the present invention.
The typhlitic Chinese medicine composition for the treatment of that object of the present invention is just to provide a kind of evident in efficacy, taking convenience, has no side effect.
Another object of invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Cortex Moutan, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Radix Rehmanniae, the Radix Aucklandiae, Radix Bupleuri, Flos Lonicerae, Fructus Aurantii Immaturus, eupolyphaga (different name Eupolyphaga Seu Steleophaga), Semen Persicae, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, Folium Camelliae sinensis, Fructus Mume, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, Herba Patriniae to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat typhlitic recurrence.Wherein select Cortex Moutan to be because its nature and flavor are arduous, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, sends out speckle , Jing Epilepsy, and tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea , mass in the abdomen, carbuncle and ulcer, flutters damage.Select the Rhizoma Anemarrhenae to be because its nature and flavor hardship is cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid, controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.Select the Radix Aucklandiae to be because its nature and flavor are arduous, warm.Enter lung, liver, spleen channel.Promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.Select Radix Bupleuri to be because its nature and flavor hardship is slightly cold, return liver, gallbladder meridian.Treating SHAO YANG disease by mediation, brings down a fever soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Fructus Aurantii Immaturus to be because its nature and flavor hardship is cold, enter spleen, stomach warp, have dispelling the stagnated QI, loose painful abdominal mass, rushes down expectorant, and the function of removing food stagnancy, controls chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.It is salty because of its nature and flavor, cold, slightly poisonous selecting eupolyphaga.Return Liver Channel.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea , mass in the abdomen mass in the abdomen.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnantly, the function of strengthening the spleen and stomach, controls food stagnation distension, vomiting regurgitation, and dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Select Folium Camelliae sinensis to be because its property bitter but sweet flavor, cool.Enter the heart, lung, stomach warp.Refresh oneself, relieving thirst and restlessness, reduces phlegm, helps digestion, diuresis, removing toxic substances.Control headache, blurred vision, kind the sleeping of sleeping more, restlessness and thirst, food stagnation expectorant is stagnant, malaria, dysentery.Selecting Fructus Mume is that temperature, enters liver because of its nature and flavor acid, spleen, and lung, large intestine channel, has convergence to promote the production of body fluid, and the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, dysentery, has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.Select Radix Et Rhizoma Rhei to be because its nature and flavor hardship, cold enters stomach, large intestine, liver footpath, have the poison of purging heat, removing mass is stagnant, the function of clots absorbing blood, controls excess-heat constipation, and delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi , lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Herba Patriniae to be because its nature and flavor are pungent, hardship, cool.Return stomach, large intestine, Liver Channel.Heat-clearing and toxic substances removing, removing blood stasis and expelling pus.For appendicitis, dysentery, enteritis, hepatitis, eye conjunctivitis, postnatal blood stasis stomachache, carbuncle furuncle.
The consumption of composition of medicine of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight:
10-20 grams of 12-20 grams of Radixs Angelicae Dahuricae of 10-20 grams of Rhizoma Anemarrhenaes of Cortex Moutan
10-20 grams of 10-20 grams of Radix Bupleuri of 10-20 grams of Radix Aucklandiae of Radix Rehmanniae
10-15 grams of 10-15 grams of eupolyphaga of 25-35 grams of Fructus Aurantii Immaturuss of Flos Lonicerae
8-15 grams of 5-12 grams of Endothelium Corneum Gigeriae Galli of 10-12 grams of Radix Paeoniae Albas of Semen Persicae
8-15 grams of 8-12 grams of Radix Et Rhizoma Rhei of 5-12 grams of Fructus Mumes of Folium Camelliae sinensis
90-110 grams of 5-8 grams of Herba Patriniaes of Radix Glycyrrhizae
Wherein, be preferably
15 grams of 15 grams of Radixs Angelicae Dahuricae of 15 grams of Rhizoma Anemarrhenaes of Cortex Moutan
15 grams of 15 grams of Radix Bupleuri of 15 grams of Radix Aucklandiae of Radix Rehmanniae
12 grams of 12 grams of eupolyphaga of 30 grams of Fructus Aurantii Immaturuss of Flos Lonicerae
10 grams of 10 grams of Endothelium Corneum Gigeriae Galli of 10 grams of Radix Paeoniae Albas of Semen Persicae
10 grams of 9 grams of Radix Et Rhizoma Rhei of 10 grams of Fructus Mumes of Folium Camelliae sinensis
100 grams of 6 grams of Herba Patriniaes of Radix Glycyrrhizae
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
2, the Rhizoma Anemarrhenae: choose decontamination, separately size, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
3, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then moistening, chip drying;
4, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;
5, the Radix Aucklandiae: crude drug in whole is put in clear water and cleaned, pull out, moistening 12-24 hour makes soft, section, dries;
6, Radix Bupleuri: get crude drug, remove residual stem, impurity, cleans, and softens, and cuts sheet, dry, and sieve removes chip;
7, Flos Lonicerae: sieve removes silt, chooses clean impurity;
8, Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant saturating, pull out, profit is to interior without hard-core, and section, dries;
9, eupolyphaga: get crude drug, cleaning, drying;
10, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
11, the Radix Paeoniae Alba: choose decontamination, separately size, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
12, Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
13, Folium Camelliae sinensis: get crude drug, remove impurity, branch stalk;
14, Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;
15, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stews to moisten to inside and outside humidity evenly, cuts into slices or is cut into small pieces, dries;
16, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, dry;
17, Herba Patriniae: get crude drug, remove impurity, water spray, slightly dries in the air, and cutting is dry.
Two, preparation
1, the Cortex Moutan of described weight, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Radix Rehmanniae, the Radix Aucklandiae, Radix Bupleuri, Flos Lonicerae, Fructus Aurantii Immaturus, eupolyphaga, Semen Persicae, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, green tea, Fructus Mume, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, Herba Patriniae are put into medicine pot, add 3 times of amounts of clear water to soak 2 hours, decoct with high heat boiling, use again slow fire boiling 10 minutes, filter to obtain decoction liquor for the first time.
2, the medicinal liquid filtering is for the first time poured out, then added 3 times of amounts of clear water, decoct with high heat boiling, then use slow fire boiling 10 minutes, filter to obtain secondary decoction liquor.
3, secondary is decocted to medicinal liquid and merge, heating garment is used.While taking for the first time, will decoct for the second time medicinal liquid and be incorporated in for the first time mix homogeneously in decoction liquor, then pour out 500 milliliters and take, while taking for the second time, medicinal liquid is placed on to the upper heating of fire can be taken.
Medicine of the present invention has reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, and circulation of qi promoting removing heat from blood, heat-clearing and toxic substances removing, effect of loose carbuncle removing food stagnancy, is used for the treatment of appendicitis instant effect, and cure rate is high.
The specific embodiment
Further set forth below the beneficial effect of medicine of the present invention by test example, these test examples comprise the report of animal toxicity test and clinical observation test.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get 40 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 20 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is by after drug dilution, adopts administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention:
1, physical data:
Accept out-patient's 350 examples for medical treatment, 35-40 years old age, 100 examples, 41-50 years old 120 example, 50-70 example 130 examples.
2, diagnostic criteria:
Light-duty class appendicitis: morbidity is from the beginning of, patient's Right Lower Abdomen pain, inappetence, low grade fever is weak, n or V.
Heavy class appendicitis: epigastrium or umbilicus be dull pain around, after a few hours, stomachache shifts in right lower abdomen, and with inappetence, n or V symptom.
3, Therapeutic Method:
Oral: every day sooner or later respectively once, each 500 milliliters.Ante cibum warm boiled water.Period in a medicine, patient answers diet life, cold, stodge.Light-duty 1-3 day, heavy 4-5 day fully recovers.
4, efficacy assessment standard:
Effective: degree type class appendicitis is after treatment, and patient's colic symptoms disappears, it is normal that body is recovered.Follow up a case by regular visits to unmanned recurrence in 1-10 years.
Take a turn for the better: patient's symptom progressively alleviates, pain disappears, and feels good, and it is normal that body constitution is recovered substantially.
Invalid: not reach improvement standard person.
5, therapeutic outcome
In the treatment of 1-3 day, by light-duty Appendicitis Patients 215 examples of Drug therapy of the present invention, effective 206 examples, 9 examples that take a turn for the better, total effective rate 100%; In the treatment of 4-5 day, with heavy Appendicitis Patients 135 examples of Drug therapy of the present invention, effective 90 examples, 43 examples that take a turn for the better, total effective rate 98.50%.

Claims (3)

1. the typhlitic medicine for the treatment of, is characterized in that: it is to be made up of the crude drug in following weight range:
10-20 grams of 12-20 grams of Radixs Angelicae Dahuricae of 10-20 grams of Rhizoma Anemarrhenaes of Cortex Moutan
10-20 grams of 10-20 grams of Radix Bupleuri of 10-20 grams of Radix Aucklandiae of Radix Rehmanniae
10-15 grams of 10-15 grams of eupolyphaga of 25-35 grams of Fructus Aurantii Immaturuss of Flos Lonicerae
8-15 grams of 5-12 grams of Endothelium Corneum Gigeriae Galli of 10-12 grams of Radix Paeoniae Albas of Semen Persicae
8-15 grams of 8-12 grams of Radix Et Rhizoma Rhei of 5-12 grams of Fructus Mumes of Folium Camelliae sinensis
90-110 grams of 5-8 grams of Herba Patriniaes of Radix Glycyrrhizae.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
15 grams of 15 grams of Radixs Angelicae Dahuricae of 15 grams of Rhizoma Anemarrhenaes of Cortex Moutan
15 grams of 15 grams of Radix Bupleuri of 15 grams of Radix Aucklandiae of Radix Rehmanniae
12 grams of 12 grams of eupolyphaga of 30 grams of Fructus Aurantii Immaturuss of Flos Lonicerae
10 grams of 10 grams of Endothelium Corneum Gigeriae Galli of 10 grams of Radix Paeoniae Albas of Semen Persicae
10 grams of 9 grams of Radix Et Rhizoma Rhei of 10 grams of Fructus Mumes of Folium Camelliae sinensis
100 grams of 6 grams of Herba Patriniaes of Radix Glycyrrhizae.
3. the preparation method of medicine as claimed in claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
(2) Rhizoma Anemarrhenae: choose decontamination, separately size, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(3) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then moistening, chip drying;
(4) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;
(5) Radix Aucklandiae: crude drug in whole is put in clear water and cleaned, pull out, moistening 12-24 hour makes soft, section, dries;
(6) Radix Bupleuri: get crude drug, remove residual stem, impurity, cleans, and softens, and cuts sheet, dry, and sieve removes chip;
(7) Flos Lonicerae: sieve removes silt, chooses clean impurity;
(8) Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant saturating, pull out, profit is to interior without hard-core, and section, dries;
(9) eupolyphaga: get crude drug, cleaning, drying;
(10) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
(11) Radix Paeoniae Alba: choose decontamination, separately size, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(12) Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
(13) Folium Camelliae sinensis: get crude drug, remove impurity, branch stalk;
(14) Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;
(15) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stews to moisten to inside and outside humidity evenly, cuts into slices or is cut into small pieces, dries;
(16) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, dry;
(17) Herba Patriniae: get crude drug, remove impurity, water spray, slightly dries in the air, and cutting is dry;
(2) preparation
(1) Cortex Moutan of described weight, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Radix Rehmanniae, the Radix Aucklandiae, Radix Bupleuri, Flos Lonicerae, Fructus Aurantii Immaturus, eupolyphaga, Semen Persicae, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, Folium Camelliae sinensis, Fructus Mume, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, Herba Patriniae are put into medicine pot, add 3 times of amounts of clear water to soak 2 hours, decoct with high heat boiling, use again slow fire boiling 10 minutes, filter to obtain decoction liquor for the first time;
(2) medicinal liquid filtering is for the first time poured out, then added 3 times of amounts of clear water, decoct with high heat boiling, then use slow fire boiling 10 minutes, filter to obtain secondary decoction liquor;
(3) secondary is decocted to medicinal liquid and merge, heating garment use, each serving with 500 grams.
CN201210178641.7A 2012-06-03 2012-06-03 Medicament for treating appendicitis and preparation method thereof Expired - Fee Related CN102657773B (en)

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