CN101121013A - Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method - Google Patents

Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method Download PDF

Info

Publication number
CN101121013A
CN101121013A CNA2006100103770A CN200610010377A CN101121013A CN 101121013 A CN101121013 A CN 101121013A CN A2006100103770 A CNA2006100103770 A CN A2006100103770A CN 200610010377 A CN200610010377 A CN 200610010377A CN 101121013 A CN101121013 A CN 101121013A
Authority
CN
China
Prior art keywords
parts
portions
radix
medicine
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006100103770A
Other languages
Chinese (zh)
Inventor
郭占友
Original Assignee
郭占友
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 郭占友 filed Critical 郭占友
Priority to CNA2006100103770A priority Critical patent/CN101121013A/en
Publication of CN101121013A publication Critical patent/CN101121013A/en
Pending legal-status Critical Current

Links

Abstract

The present invention provides a medicine, which cures a refractory canker sore, Behcet disease and a sjogren syndrome and a preparation method of the medicine. The symptoms are common clinical diseases at present. The current domestic and overseas treatments can only relieve the external symptoms; a curative effect is not ideal and the diseases are easy to recrudesce. The component of the present invention includes Chinese traditional medicines, and the weight portion ratio of the Chinese traditional medicines is 10 portions dried rehmannia root, 10 portions dyers woad leaf, 8 portions danshen root, 5 portions milk vetch root, 6 portions heterophylly falsesatarwort root, 5 portions aweto, 6 portions tuber of dwarf lilyturf, 3 portions Manchurian wildginger, 8 portions cistanche, 8 portions red peony root, 6 portions lonicera, 10 portions green bristle grass, 6 portions herb of wild mint, 6 portions Chinese thorowax root, 5 portions ginseng and 10 portions largehead atractylode. The component of the present invention also includes 10 portions dangshen, 9 portions scutellaria, 9 portions moutan bark, 10 portions lophatherum, 10 portions talc, 6 portions coptis chinensis, 6 portions fresh ginger and 10 portions glycyrrhizae. A leechdom of the present invention cures the refractory canker sore, the Behcet disease and the sjogren syndrome.

Description

Treatment intractable oral cavity ulcer, behcets disease, dry syndrome medicine and method for making
Technical field:
The present invention relates to a kind of medicine and preparation method for the treatment of intractable oral cavity ulcer, behcets disease, dry syndrome.
Background technology:
Oral ulcer, behcets disease, dry syndrome are present commonly encountered diseases clinically, and nearly several the morbidity has the trend that increases year by year, and the medicine for the treatment of primary disease at present both at home and abroad is many based on antibiotic, vitamin, hormone, immune formulation.Above various kinds of drug can only be alleviated surface symptoms, and curative effect is undesirable, and drug withdrawal is easily recurred.The patient must not take medicine for a long time and keep, and is easy to generate Drug resistance and other organ of infringement, so invent the fervent expectation that a kind of this disease for the treatment of both the principal and secondary aspects of a disease treatment by Chinese herbs has become extensive patients.
Intractable oral cavity ulcer, behcets disease, dry syndrome are present commonly encountered diseases clinically, and morbidity in recent years has the trend that increases year by year, and its cardinal symptom is: 1.The ulcer that the grain of rice to Semen Glycines is differed in size appears in intractable oral cavity ulcer, oral mucosa, gingiva, tongue body throat for a long time: the traditional Chinese medical science is called " aphtha " owing to take antibiotic, sulfonamide for a long time.Make in the body strain imbalance or can not thoroughly cure repeatedly by oral ulcer, easily send out canceration or transfer behcets disease to by (as lupus erythematosus) due to the collagenosis.2。The behcets disease clinical manifestation is for being kind of an agnogenic autoimmune disease, with the oral ulcer of showing effect repeatedly.(1) eye pathological changes such as conjunctivitis, retinitis, iridocyclitis, hypopyon keratitis, choroiditis, optic papillitis, optic atrophy.(2) genital ulcer, the male mainly betides penis and glans penis also urethra can take place, and the women mainly betides big nympha also can betide vagina and cervix uteri.Between stage of attack with regional glandular enlargement.(3) skin symptom: erythra comprises, vesicle, pustule, pus skin infections, folliculitis, acne, furuncle abscess, erythema nodosum and the infringement of erythema multiforme sample.(4) the joint symptom shows as multiple wandering arthritis.Red, swollen, hot, the pain and hydrarthrosis all take place.(5) blood vessel symptom, big and small vessel all can be got involved, and the vein pathological changes is more than tremulous pulse.Be generally the shallow table of recurrent or deeply in the property thrombophlebitis.(6) nervous system lesion, brain, cerebellum, spinal cord, meninges cranial nerves etc. can cause the meningitis syndrome, group after the brain stem disease, organic mental disorder symptom etc., central nervous system's pathological changes prognosis is comparatively serious.Mortality rate is higher, the general symptom of special brain stem (7): the lighter's General Symptoms, or random thoughts are tired unable, joint aches, headache and dizzy, appetite descends, (8) oral ulcer loses weight: first symptom who with the oral ulcer is primary disease is taken up an area of about 70%, the incidence rate of oral ulcer is up to more than 95% in the whole course of disease, all the time the person is few not have the pathological change of oral cavity, rounded or the oval diameter 2-10mm of ulcer boundary is clear, and the depth is not moved the center faint yellow downright bad substrate, is scarlet tinge on every side, the dark person of ulcer, more stay cicatrix after, ulcer is single-shot or multiple, betides lip gum oral mucosa, soft palate, hard palate, tongue, tonsil, throat is so that esophagus and nasal cavity.(9) other system's pathological changes primary disease also can concurrent epididymitis, urethritis, interstitial pneumonia, myocarditis, Crohn disease, non-specific gastrointestinal tract inflammation and ulcer, pancreatitis, tonsillitis, female patient can cause the confusion of the menstrual cycle.
Sjogren syndrome is a kind of infringement external secretion body of gland, especially based on the chronic systemic autoimmune disease of salivary gland and lachrymal gland.Its characteristics are that lachrymal gland and salivary gland secretion reduce, and form keratitis sicca and xerostomia.It involves its other organs simultaneously and system causes diversified clinical manifestation.In the organ of getting involved, can see a large amount of lymphocytic infiltrations, also diversified autoantibody can occur in the serum.But the primary disease individualism also can appear at other sure autoimmune disease such as rheumatoid arthritiss, system lupus erythematosus system sclerosis etc.
(1) the body of gland symptom 1.Dry mouth levy because of saliva few due to, see 80% patient.Severe patient needs drinking-water again and again when carrying water tumbler because of speech, must send down by water when advancing food.The drinking-water of waking up midnight quenches one's thirst.2。Rampant caries: refer to that the patient a plurality of manageable dental caries 50% above patients occur and occurs.3。Sialadenitis: the parotid gland or submaxillary gland repeatedly, bilateral replaces enlargement, companion pain or tenderness have body temperature rise sometimes, see 40% patient.4。Keratoconjunctivitis sicca, promptly xerophthalmia scheorma is levied, and it is dry and astringent to go out to lose face, the few tear of foreign body sensation, severe patient is too deep for tears.Part occurs being envious, keeps in dark place, eyestrain or visual deterioration.
(2) mucocutaneous: 1.Purpura sample erythra: have more present lower limb.Be grain of rice size, clear-cut red point, color transfers to dim redly in time, occurs in batches, and every batch continues about 10 days, disappears voluntarily, and losing has pigmentation.2。Erythema nodosa sample erythra.3。Oral ulcer 4.Raynaud phenomenon.
(3) joint, muscle are as seen weak, myasthenia (90%) pain of joint muscle 70% but the arthritis space change takes place and the different person of sclerotin rare.
(4) kidney: renal tubule acidosis can occur, kidney urine collapses renal glucosuria, kidney osteomalacia, part patient can form the urinary system calculus.
(5) respiratory system: can cause dry nasal cavity, have a bad nose, persistence hoarseness, chronic bronchitis, pulmonary fibrosis interstitial pneumonia etc.
(6) gastroenteritis: pharynx and esophagus drying cause dysphagia.Achlorhydria, chronic atrophic gastritis, intestinal juice reduces can cause constipation.
(7) liver: cause the liver enlargement.Chronic active hepatitis, liver cirrhosis etc.
(8) nervous system: the concurrent intracranial vessel inflammation of minority case, hemiplegia, hemianopsia, psychological problem, and peripheral neuropathy.
(9) blood system: normal greedy blood or the leukocyte thrombocytopenia of occurring.
(10) lymphsystem: lymphatic infiltration appears at the outer internal organs of body of gland, as kidney, and interstitial lung etc.; Lymphatic infiltration mainly is confined to the external secretion body of gland; Lymphocyte malignant change occurs and becomes malignant lymphoma.
(11) other: thyropathy as chronic lymphocytic thyroiditis, also has the concurrent diabetes of small number of patients in addition.
The patient is very painful, has a strong impact on the normal live and work of patient.
The medicine of treatment primary disease is many based on antibiotic, vitamin, hormone, immune formulation both at home and abroad at present.Above various kinds of drug can only be alleviated surface symptoms, and curative effect is undesirable, and drug withdrawal is easily recurred.The patient must not take medicine for a long time and keep, and is easy to generate Drug resistance and other organ of infringement, treats this disease so invent a kind for the treatment of both the principal and secondary aspects of a disease Chinese medicine, has become the fervent expectation of extensive patients.
Summary of the invention: the object of the present invention is to provide to have blood circulation promoting and blood stasis dispelling, antiinflammatory, pain relieving, heat-clearing and toxic substances removing, Yin-nourishing and body fluid promoting, the suppressing the hyperactive liver kidney tonifying, loosening bowel to relieve constipation, the Chinese medicine composition of microcirculation improvement, this product energy human body immunity improving ability, be a kind of treatment intractable oral cavity ulcer, the dry comprehensive sick Chinese medicine of behcets disease.
Above-mentioned purpose is achieved through the following technical solutions:
The medicine of treatment intractable oral cavity ulcer, behcets disease, dry syndrome, its composition comprises: Chinese medicine, ratio of weight and number is: 10 parts in the Radix Rehmanniae, 10 parts of Folium Isatidiss, 8 parts of Radix Salviae Miltiorrhizaes, 5 parts of the Radixs Astragali, 6 parts of Radix Pseudostellariaes, 5 parts of Cordycepss, 6 parts of Radix Ophiopogonis, 3 parts of Herba Asaris, 8 parts of Herba Cistanches, 8 parts of Radix Paeoniae Rubra, 6 parts of Flos Lonicerae, 10 parts of JIUWEICAO, 6 parts of Herba Menthaes, 6 parts of Radix Bupleuri, 5 parts of Radix Ginsengs, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Codonopsis, 9 parts of Radix Scutellariae, 9 parts of Cortex Moutans, 10 parts on Folium Bambusae, 10 parts in Talcum, 6 parts of Rhizoma Coptidis, 6 parts in Rhizoma Zingiberis Recens, 10 parts in Radix Glycyrrhizae.
The medicine of described treatment intractable oral cavity ulcer, behcets disease, dry syndrome, described Chinese medicine also comprises: 10 parts of Rhizoma Polygonati Odorati, 10 parts of Fructus Ligustri Lucidi, 8 parts of the Rhizoma Anemarrhenaes, 10 parts of the Radix Paeoniae Albas, 10 parts of Herba Dendrobiis, 10 parts of Fructus Cannabis, 10 parts of Flos Chrysanthemis, 10 parts of Radix Asparagis are ratio of weight and number.
The medicine of described treatment intractable oral cavity ulcer, behcets disease, dry syndrome, described above each medicine by dry, sterilize, pulverize, sieve, mix homogeneously, packing make powder.
This technical scheme has following beneficial effect
1. through Clinical Laboratory, this product obviously has blood circulation promoting and blood stasis dispelling, antiinflammatory, pain relieving, heat-clearing and toxic substances removing, Yin-nourishing and body fluid promoting, suppressing the hyperactive liver kidney tonifying, loosening bowel to relieve constipation, microcirculation improvement, human body immunity improving ability, reduce other complication has remarkable result.
2. this product is a kind of treatment intractable recurrent oral ulceration, behcets disease, dry syndrome drug of first choice, effective, evident in efficacy, and be difficult for recurrence after the drug withdrawal, the patient does not take medicine for a long time at needs and keeps, do not develop immunity to drugs evoke complication cause other organ disease.
3. medicine of the present invention is through the evidence safety non-toxic, to the treatment intractable oral cavity ulcer, and behcets disease, dry syndrome has certain curative effect, and its toxicology and pharmacodynamic experiment data are as follows:
A. give mouse stomach with Cmax and the maximum gastric capacity of irritating, per 6 hours once, every day 4 times, observe in the administration 24 hours and afterwards 7 days, tried mice and other abnormal response do not occur extremely reaching, it is that 126.3 parts/k part is that the clinical adult of this medicine consumption every day (every day 3 times) adds up to 21.025 parts/k of crude drug part body weight for each 5 parts that experiment records the mice maximum tolerated dose) 404.32 times.The consumption per day that shows medicine of the present invention is safe.
B. long term toxicity test, give the rat oral gavage administration with 1 part/k part, 5 parts/k part (4.51 parts/k of symphysis medicine part, 21.46 parts/k part) respectively, once a day, continuous irrigation stomach 60 days, result of the test shows, is tried general state action and the diet situation of rat and shines thin indifference, hematology, liver function renal function and organ coefficient and matched group relatively do not have significant difference, show that life-time service medicine of the present invention is safe.
C. to rabbit due to the sulfanilamide, the oral ulcer behcets disease, xerotic influence, sneaking into sulphonamides (1%) at feedstuff gives around rabbit feeds continuously, simultaneously every day gastric infusion 1 time, matched group is given with pharynx-clearing throat-benefiting and is loose, horizontal type contrast to normal saline with volume, measured serum and sulphonamides content in 24 hours after the successive administration last administration all around, result of the test sees Table 1:
The influence of sulphonamides in rabbit sulfanilamide model serum and the bile due to the table 1 pair sulfanilamide
Group Dosage (part/k part) Number of animals only Sulfanilamide content in the serum (mm01/1x ± SD) Sulfanilamide content (mm01/0) in the bile (x ± SD)
The scattered reason saline of dosage group small dose group pharynx-clearing throat-benefiting in heavy dose of group 0.562 0.281 0.143 0.280 same volume 8 8 8 8 8 3.15±0.76 5.40±0.91 6.08±1.04 5.20±1 8.30±1.40 6.32±3.20 7.20±2.90 9.43±3.70 10.73±3.00 15.76±4.10
The result shows, medicine of the present invention may reduce due to the sulfanilamide in the rabbit anteserum and the sulfanilamide content (P<001) that raises in the bile
The influence of rabbit sulphonamides due to the table 2 pair sulfanilamide
Fine distinction Dosage part/k part Number of animals (only) Ulcer and dry incidence rate (%) The P value
The scattered reason saline of dosage group small dose group pharynx-clearing throat-benefiting in heavy dose of group 0.5 0.25 0.125 0.120 same volume 8 8 8 8 8 30.00 41.00 64.10 36.30 36.30 <0.05 >0.05 >0.05 >0.05
The result shows: medicine of the present invention is to rabbit sulfanilamide due to the sulfanilamide, oral ulcer behcets disease xerosis be formed with tangible resistancing action.
The main pharmacodynamics result of study shows: medicine of the present invention has effect.
Patient's clinical manifestation:
Liu, woman, 43 years old.Showed effect 5 years repeatedly in pharyngeal and perineal position place, oral cavity, the hot first quarter moon that occurs together is surplus.38 ℃ of intravenous drip glucoses of body temperature 300ml penicillin, 6,400,000/l once a day, one week of treatment, sb.'s illness took a favorable turn, body temperature is normal, and spiritlessness and weakness appears in the patient, and whole body arthralgia; yellow urine; be hard and dry and irritated irritability is diagnosed as Behcet disease (traditional Chinese medical science claims hu huo syndrome) and takes pharynx-clearing throat-benefiting and loose each one bag of every day 3 times, takes the surplus above symptom improvement of first quarter moon; take and heal full half a year, follow up a case by regular visits to after 6 years and do not see disease relapse.
Leaf, man 29 years old, it is invalid through multi-treatment to suffer from behcets disease 5 years, control disease with hormone and yield to each 8 of every day 3 times, can not work, the preceding court of a feudal ruler of visual deterioration corneal ulcer is long-pending dense, erythema nodosum appears in lower limb, arthralgia, and unable to walk rises, headache, dizzy thrombo-endarteritis, no adenopathy, cloudy joint, glans penis, many places ulcer appears in anus, and malaise is taken pharynx-clearing throat-benefiting and loose, each one bag of every day 3 times, course of treatment of medication, symptom obviously alleviates, three all symptom complete obiterations course of treatment, medication returned to one's perfect health after 1 year, followed up a case by regular visits to and did not see recurrence in 5 years.
Lee 70 years old is diagnosed as xerosis before tens, and the patient goes out xerostomia, saliva is reduced, and carries water tumbler when serious, needs drinking-water again and again during speech, feed must be sent down by water the drinking-water of waking up midnight, salivary gland, bilateral replaces enlargement, companion's pain or tenderness, fervescence sometimes, keratitis sicca, it is dry and astringent to go out to lose face, and foreign body sensation is too deep for tears when serious, occur furious, keep in dark place eyestrain or visual deterioration, joint, muscle is weak, renal tubule acidosis appears in myasthenia, dry nasal cavity chronic atrophic gastritis (traditional Chinese medical science claims axersis).Take pharynx-clearing throat-benefiting and loose, every day three times, each bag is taken remission in three months, cures fully after eight courses of treatment, follows up a case by regular visits to and does not see recurrence in 4 years.
Poplar: 6 years old, suffer from oral ulcer, more than a year, tongue abdomen, mouthful end, pharyngeal, soft or hard palate appear, gingiva a rice tears soybean grain occurs and differs in size.Ulcer (traditional Chinese medical science is called " aphtha ") is taken pharynx-clearing throat-benefiting and is loose, and every day three times, each half bag is taken and thoroughly cured in three months, follows up a case by regular visits to and does not see recurrence in 4 years.
The contrast clinical observation of medical effect: according to the degree of the state of an illness, be divided into 2 groups, every group 5 people
Use for first group 5, antibiotics,, vitamin, hormone, immune formulation treatment.
Second group of 5 people uses treatment by Chinese herbs.
The result: the state of an illness that first group of 5 people uses the said method treatment to observe the patient half a year can only controlledly can not reach cures purpose fully.Often recurrence.Second group of 5 people uses treatment by Chinese herbs, and the state of an illness that observe half a year can thoroughly not cured and can be recurred.
Using method: adult every day three times, each 8 grams.The standard of medical effect evaluation: all remissions are named effective.All transference cures, recovery from illness is named in no longer recurrence after the healing.Statistical result is effective 100%, fully recovers 98% invalid 0%.
White plug syndrome: 1. different anemias of degree, total white blood cells increases.
The physics and chemistry diagnosis: 1. class moves to left, and balances each other with a pad.2. erythrocyte sedimentation rate speeds; 3. serum a2 and r ball increase in vain, the c reactive protein positive of some cases.4. the rheumatoid factor positive.5. blood circulation immune complex (C1C) increases.6. can check autoantibody among the part patients serum to oral mucosa.7.T cell subsets CD4CD8 ratio descends; 8. acupuncture reaction.
Dry physics and chemistry result: 1. to soak kitchen range 〉=0.25mm positive for the mononuclear cell of mucous membrane of lower lip biopsy.2. have in the saliva flow rate wantonly 1 positive.3. the anti-SSA anti-SSB antibody of the serum positive.
Embodiment 1:
The treatment intractable oral cavity ulcer, behcets disease, the medicine of dry syndrome, its composition comprises: Chinese medicine, ratio of weight and number is: 10 kilograms in the Radix Rehmanniae, 10 kilograms of Folium Isatidiss, 8 kilograms of Radix Salviae Miltiorrhizaes, 5 kilograms of the Radixs Astragali, 6 kilograms of Radix Pseudostellariaes, 5 kilograms of Cordycepss, 6 kilograms of Radix Ophiopogonis, 3 kilograms of Herba Asaris, 8 kilograms of Herba Cistanches, 8 kilograms of Radix Paeoniae Rubra, 6 kilograms of Flos Lonicerae, 10 kilograms of JIUWEICAO, 6 kilograms of Herba Menthaes, 6 kilograms of Radix Bupleuri, 5 kilograms of Radix Ginsengs, 10 kilograms of the Rhizoma Atractylodis Macrocephalaes, its composition also comprises: 10 kilograms of Radix Codonopsis, 9 kilograms of Radix Scutellariae, 9 kilograms of Cortex Moutans, 10 kilograms on Folium Bambusae, 10 kilograms in Talcum, 6 kilograms of Rhizoma Coptidis, 6 kilograms in Rhizoma Zingiberis Recens, 10 kilograms in Radix Glycyrrhizae.
Embodiment 2:
The medicine of described treatment intractable oral cavity ulcer, behcets disease, dry syndrome, described Chinese medicine also comprises: 10 kilograms of Rhizoma Polygonati Odorati, 10 kilograms of Fructus Ligustri Lucidi, 8 kilograms of the Rhizoma Anemarrhenaes, 10 kilograms of the Radix Paeoniae Albas, 10 kilograms of Herba Dendrobiis, 10 kilograms of Fructus Cannabis, 10 kilograms of Flos Chrysanthemis, Radix Asparagi are counted ratio for the weight kilogram for 10 kilograms.
Embodiment 3:
Drying, the sterilization by routine of the preparation method of the medicine of described treatment intractable oral cavity ulcer, behcets disease, dry syndrome, described above each medicine, pulverize, sieve, mix homogeneously, packing make powder.

Claims (3)

1. medicine for the treatment of intractable oral cavity ulcer, behcets disease, dry syndrome, its composition comprises: Chinese medicine, ratio of weight and number is: 10 parts in the Radix Rehmanniae, 10 parts of Folium Isatidiss, 8 parts of Radix Salviae Miltiorrhizaes, 5 parts of the Radixs Astragali, 6 parts of Radix Pseudostellariaes, 5 parts of Cordycepss, 6 parts of Radix Ophiopogonis, 3 parts of Herba Asaris, 8 parts of Herba Cistanches, 8 parts of Radix Paeoniae Rubra, 6 parts of Flos Lonicerae, 10 parts of JIUWEICAO, 6 parts of Herba Menthaes, 6 parts of Radix Bupleuri, 5 parts of Radix Ginsengs, 10 parts of the Rhizoma Atractylodis Macrocephalaes is characterized in that: its composition also comprises: 10 parts of Radix Codonopsis, 9 parts of Radix Scutellariae, 9 parts of Cortex Moutans, 10 parts on Folium Bambusae, 10 parts in Talcum, 6 parts of Rhizoma Coptidis, 6 parts in Rhizoma Zingiberis Recens, 10 parts in Radix Glycyrrhizae.
2. the medicine of treatment intractable oral cavity ulcer according to claim 1, behcets disease, dry syndrome is characterized in that: described Chinese medicine also comprises: 10 parts of Rhizoma Polygonati Odorati, 10 parts of Fructus Ligustri Lucidi, 8 parts of the Rhizoma Anemarrhenaes, 10 parts of the Radix Paeoniae Albas, 10 parts of Herba Dendrobiis, 10 parts of Fructus Cannabis, 10 parts of Flos Chrysanthemis, Radix Asparagi are ratio of weight and number for 10 parts.
3. the preparation method of the medicine of claim 1 or 2 described treatment intractable oral cavity ulcers, behcets disease, dry syndrome is characterized in that: described above each medicine by dry, sterilize, pulverize, sieve, mix homogeneously, packing make powder.
CNA2006100103770A 2006-08-07 2006-08-07 Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method Pending CN101121013A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNA2006100103770A CN101121013A (en) 2006-08-07 2006-08-07 Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA2006100103770A CN101121013A (en) 2006-08-07 2006-08-07 Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method

Publications (1)

Publication Number Publication Date
CN101121013A true CN101121013A (en) 2008-02-13

Family

ID=39083651

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006100103770A Pending CN101121013A (en) 2006-08-07 2006-08-07 Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method

Country Status (1)

Country Link
CN (1) CN101121013A (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101804174B (en) * 2009-02-12 2011-08-03 上海中医药大学附属龙华医院 Traditional Chinese medicine preparation for treating sicca syndrome
CN102389537A (en) * 2011-11-11 2012-03-28 哈尔滨市天地仁医药科技有限公司 Traditional Chinese medicine for treating oral cavity ulcer
CN101601827B (en) * 2008-06-10 2012-04-18 孙开珍 Traditional Chinese medicine for preventing and/or treating dry syndrome and slowing down aging and preparation method thereof
CN102526549A (en) * 2012-02-05 2012-07-04 张爱霞 Chinese medicinal preparation for treating herpetic stomatitis
CN102526596A (en) * 2012-02-05 2012-07-04 侯丽艳 Traditional Chinese medicine for treating sicca syndrome
CN102579902A (en) * 2012-03-20 2012-07-18 长春英平药业有限公司 Chinese medicine composition for curing sicca syndrome and preparation method thereof
CN102579778A (en) * 2012-03-10 2012-07-18 楚小培 Traditional Chinese medicine for treating Behcet disease and Behcet syndrome
CN102600365A (en) * 2012-03-31 2012-07-25 孔德红 Drug for treatment of oral ulcers
CN102755544A (en) * 2012-06-24 2012-10-31 宁波市鄞州浩斯瑞普生物科技有限公司 Medicament for preventing dental ulcer
CN102935177A (en) * 2012-12-08 2013-02-20 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating sjogren syndrome as well as preparation method and application thereof
CN103520508A (en) * 2013-10-25 2014-01-22 刘晓伟 Traditional Chinese medicine for treating intestinal behcet disease
CN103610973A (en) * 2013-11-22 2014-03-05 青岛市市立医院 Chinese medicine pill for treating periodontitis and preparation method thereof
CN103638502A (en) * 2013-12-12 2014-03-19 苏振华 Medicament for treating behcet disease and preparation method of medicament
CN103751750A (en) * 2014-01-26 2014-04-30 王莉 Medicine for treating oral ulcer and preparation method thereof
CN103830707A (en) * 2014-03-12 2014-06-04 张勇 Traditional Chinese medicine for treating aphtha caused by insufficiency of heart and spleen and preparation method thereof
CN103989162A (en) * 2014-04-25 2014-08-20 贵州三泓药业股份有限公司 Health-care pseudostellaria root oral liquid
CN104069230A (en) * 2014-07-10 2014-10-01 山东青岛中西医结合医院 Toxin-expelling dampness-removing soup for treating Behcet's disease
CN104147247A (en) * 2014-09-04 2014-11-19 尹光山 Medicine for treating Yang-deficiency Qi-weakness type recurrent oral ulceration
CN104306721A (en) * 2014-11-07 2015-01-28 朱海燕 Traditional Chinese medicine composition for sjogren syndrome as well as preparation method and application
CN104997956A (en) * 2015-07-30 2015-10-28 庞群 Behcet's syndrome and treatment drug thereof
CN105497565A (en) * 2016-01-15 2016-04-20 黎余英 Traditional Chinese medicine for treating Behcet's disease

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101601827B (en) * 2008-06-10 2012-04-18 孙开珍 Traditional Chinese medicine for preventing and/or treating dry syndrome and slowing down aging and preparation method thereof
CN101804174B (en) * 2009-02-12 2011-08-03 上海中医药大学附属龙华医院 Traditional Chinese medicine preparation for treating sicca syndrome
CN102389537A (en) * 2011-11-11 2012-03-28 哈尔滨市天地仁医药科技有限公司 Traditional Chinese medicine for treating oral cavity ulcer
CN102526549A (en) * 2012-02-05 2012-07-04 张爱霞 Chinese medicinal preparation for treating herpetic stomatitis
CN102526596A (en) * 2012-02-05 2012-07-04 侯丽艳 Traditional Chinese medicine for treating sicca syndrome
CN102579778A (en) * 2012-03-10 2012-07-18 楚小培 Traditional Chinese medicine for treating Behcet disease and Behcet syndrome
CN102579902A (en) * 2012-03-20 2012-07-18 长春英平药业有限公司 Chinese medicine composition for curing sicca syndrome and preparation method thereof
CN102579902B (en) * 2012-03-20 2014-12-31 长春英平药业有限公司 Chinese medicine composition for curing sicca syndrome and preparation method thereof
CN102600365A (en) * 2012-03-31 2012-07-25 孔德红 Drug for treatment of oral ulcers
CN102755544A (en) * 2012-06-24 2012-10-31 宁波市鄞州浩斯瑞普生物科技有限公司 Medicament for preventing dental ulcer
CN102755544B (en) * 2012-06-24 2014-01-01 宁波市鄞州福瑞达生物科技有限公司 Medicament for preventing dental ulcer
CN102935177B (en) * 2012-12-08 2014-08-13 新乡医学院第一附属医院 Traditional Chinese medicine composition for treating sjogren syndrome as well as preparation method and application thereof
CN102935177A (en) * 2012-12-08 2013-02-20 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating sjogren syndrome as well as preparation method and application thereof
CN103520508A (en) * 2013-10-25 2014-01-22 刘晓伟 Traditional Chinese medicine for treating intestinal behcet disease
CN103610973A (en) * 2013-11-22 2014-03-05 青岛市市立医院 Chinese medicine pill for treating periodontitis and preparation method thereof
CN103610973B (en) * 2013-11-22 2016-01-20 青岛市市立医院 A kind of medicine pill for the treatment of periodontitis and preparation method thereof
CN103638502A (en) * 2013-12-12 2014-03-19 苏振华 Medicament for treating behcet disease and preparation method of medicament
CN103638502B (en) * 2013-12-12 2015-07-01 苏振华 Medicament for treating behcet disease and preparation method of medicament
CN103751750B (en) * 2014-01-26 2016-01-06 王莉 A kind of medicine for the treatment of oral ulcer and preparation method thereof
CN103751750A (en) * 2014-01-26 2014-04-30 王莉 Medicine for treating oral ulcer and preparation method thereof
CN103830707A (en) * 2014-03-12 2014-06-04 张勇 Traditional Chinese medicine for treating aphtha caused by insufficiency of heart and spleen and preparation method thereof
CN103989162A (en) * 2014-04-25 2014-08-20 贵州三泓药业股份有限公司 Health-care pseudostellaria root oral liquid
CN104069230B (en) * 2014-07-10 2016-06-15 山东青岛中西医结合医院 A kind of treat behcets disease gram poison wet soup
CN104069230A (en) * 2014-07-10 2014-10-01 山东青岛中西医结合医院 Toxin-expelling dampness-removing soup for treating Behcet's disease
CN104147247A (en) * 2014-09-04 2014-11-19 尹光山 Medicine for treating Yang-deficiency Qi-weakness type recurrent oral ulceration
CN104147247B (en) * 2014-09-04 2015-03-25 尹光山 Medicine for treating Yang-deficiency Qi-weakness type recurrent oral ulceration
CN104306721A (en) * 2014-11-07 2015-01-28 朱海燕 Traditional Chinese medicine composition for sjogren syndrome as well as preparation method and application
CN104997956A (en) * 2015-07-30 2015-10-28 庞群 Behcet's syndrome and treatment drug thereof
CN105497565A (en) * 2016-01-15 2016-04-20 黎余英 Traditional Chinese medicine for treating Behcet's disease

Similar Documents

Publication Publication Date Title
CN101121013A (en) Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method
CN102688420B (en) Traditional Chinese medicine decoction for treating psoriasis
CN101224282A (en) Medicine compounds for treating infantile anorexia and preparing method thereof
CN104096154A (en) Traditional Chinese medicine composition for treating oral ulcer
CN104288315A (en) Traditional Chinese medicine composition for resisting superbacteria NDM-1 drug resistance gene bacteria
CN103536742B (en) A kind ofly treat pharmaceutical composition of chronic enterogastritis disease and preparation method thereof
CN103585514A (en) Traditional Chinese medicine composition for treating stomach cancer, application and preparation
CN100364594C (en) Medicine for treating chronic superficial gastritis and peptic ulcer diseases
CN104771697A (en) Pharacetuical composition for treating cholecystitis
CN104288296A (en) Traditional Chinese medicine composition for treating cholelithiasis
CN103301353B (en) Pharmaceutical composition for treating atrophic vaginitis
CN105832991A (en) Traditional Chinese medicine composition for treating gastritis
CN103182059A (en) Traditional Chinese medicine composition for treating chronic gastritis, and application thereof
CN103705796A (en) Medicinal composition for treating diarrhea, and preparation method thereof
CN1903347A (en) Medicine composition for treating alimentary canal diseases, prepn. method and application thereof
CN104622995A (en) Pharmaceutical composition for treating chronic superficial gastritis and preparation method of pharmaceutical composition
CN100371005C (en) A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof
CN103041160B (en) Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof
CN105213780A (en) A kind of Chinese medicine composition and application thereof for the treatment of chronic gastritis
CN105267639A (en) Pharmaceutical preparation used for treating chronic gastritis
CN112891485B (en) Traditional Chinese medicine composition for treating neocoronary pneumonia
CN104547922A (en) Chinese medicinal composition for treating prostatitis and preparation method thereof
CN106563076B (en) Medicine for treating stomach disease and its preparing method
CN104367754A (en) Traditional Chinese medicine for treating rheumatoid arthritis
CN101264143B (en) Chinese medicine preparation for treating gynecologic inflammation and preparation thereof

Legal Events

Date Code Title Description
PB01 Publication
C06 Publication
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
WD01 Invention patent application deemed withdrawn after publication

Open date: 20080213

C02 Deemed withdrawal of patent application after publication (patent law 2001)