CN1977899B - Medicine for treating rheumatoid arthritis - Google Patents

Medicine for treating rheumatoid arthritis Download PDF

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CN1977899B
CN1977899B CN2005101284425A CN200510128442A CN1977899B CN 1977899 B CN1977899 B CN 1977899B CN 2005101284425 A CN2005101284425 A CN 2005101284425A CN 200510128442 A CN200510128442 A CN 200510128442A CN 1977899 B CN1977899 B CN 1977899B
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medicine
rheumatoid arthritis
radix
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joint
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CN1977899A (en
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颜正东
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Abstract

The present invention discloses a Chinese medicine for curing rheumatoid arthritis with obvious therapeutic effect. Said Chinese medicine can be made into decoction, pills, capsule and ointment, etc. and its made up by using 12 Chinese medicinal materials of red ginseng, degetatinated deer antlet, ovate atractylodes root, prepared flowery knotweed root, tetrandra root, licorice root and others. Its effective rate is 98% and its cure rate is 91%.

Description

A kind of medicine for the treatment of rheumatoid arthritis
[technical field]
The present invention relates to a kind of medicine for the treatment of rheumatoid arthritis, belong to the field of Chinese medicines.
[background technology]
Rheumatoid arthritis is the chronic systemic autoimmune disease based on arthropathy, and typical clinical manifestation be the symmetric multiple little arthritis of showing effect repeatedly, and the joint is the easiest gets involved with hands, wrist, foot etc.Present red and swollen heat pain in early days, dysfunction, late period, in various degree stiff and lopsided can appear in the joint, and skeletal muscle atrophy arranged, the disability rate height.Belong to traditional Chinese medical science arthromyodynia scope, the title of " insensitive impediment " is arranged.At present, the proved recipe of the rheumatoid arthritis that heals with medicine is more, as " a surname's numbness soup ", " Radix Angelicae Sinensis is picked up pain soup " etc., though it has certain curative effect to rheumatoid arthritis, but still there is unhappy, the easy bounce-back of curative effect in existing Chinese medicine preparation, is difficult to deficiencies such as radical cure, and is still unsatisfactory.
[summary of the invention]
For a long time, there is urgent needs in people's medicine that curative effect is better treated rheumatoid arthritis.Up to now, do not find the report of relevant drug compound preparation of the present invention.The inventor is through research repeatedly, and the checking repeatedly by long-term practice and clinical trial, has found the compound Chinese medicinal preparation that the treatment of better curative effect rheumatoid arthritis is arranged finally, thereby has finished the present invention.
Purpose of the present invention just provides a kind of medicine of more effectively treating rheumatoid arthritis, and particularly a kind of treatment rheumatoid arthritis is simple and effective, treating both the principal and secondary aspects of a disease, and once healing, the compound Chinese medicinal preparation that is difficult to recur.
For achieving the above object, the present invention is realized by following technical proposals.A kind of medicine for the treatment of rheumatoid arthritis is the medicament of being made by the following traditional Chinese medicine raw weight proportion:
Radix Ginseng Rubra 8-15g Cornu Cervi Degelatinatum 10-20g Rhizoma Atractylodis Macrocephalae 5-25g baked polygonum capitatum 15-40g
Radix Stephaniae Tetrandrae 10-30g Radix Tripterygii Wilfordii 8-25g Herba Ephedrae 5-15g Hirudo 2-8g
Scolopendra 0.5-2g Natrii Sulfas 1-10g Radix Cynanchi Paniculati 10-30g Radix Glycyrrhizae 5-15g
A kind of its preferred weight proportioning of medicine for the treatment of rheumatoid arthritis of the present invention is:
Radix Ginseng Rubra 10g Cornu Cervi Degelatinatum 10g Rhizoma Atractylodis Macrocephalae 20g baked polygonum capitatum 20g
Radix Stephaniae Tetrandrae 15g Radix Tripterygii Wilfordii 15g Herba Ephedrae 6g Hirudo 6g
Scolopendra 3g Natrii Sulfas 6g Radix Cynanchi Paniculati 15g Radix Glycyrrhizae 6g
Medicine of the present invention adopts fried one-tenth Chinese medicine decoction for oral administration usually.Also can adopt the conventional method of Chinese medicine preparation to be prepared into multiple conventional oral preparations.For example above-mentioned formula material medicine pulverize mix homogeneously can be made pill, capsule or soft extract.Rheumatoid arthritis is touching and refractory belongs to the insensitive impediment in the traditional Chinese medical science arthromyodynia.At present, the world of medicine does not also have ideal Drug therapy primary disease, and western countries also just treat on antiinflammatory, pain relieving and course of disease delayer.Adopt Chinese traditional treatment, though certain curative effect is arranged, arrive the present from ancient times, ancient Chinese medicine doctor is adhered rigidly to old maxim, the principle that lattice are kept expelling wind and cold, heat clearing and damp drying, invigorated blood circulation, adopt the Therapeutic Method of general arthromyodynia, unsatisfactory, often can only relief of symptoms, can not stop the development of the state of an illness, swollen healing bitterly more cured in have even appearance, forms vicious cycle, and patient suffers untold misery.It has its source in, and just takes stopgap measures usually, and damp-clearing pain-relieving does not effect a permanent cure, and setting upright could reducing swelling and alleviating pain.
Rheumatoid arthritis is different from general rheumatic Bi syndrome, should have only the deep study cause of disease from being added on understanding with integral body in essence, just can suit the remedy to the case, and really reaches ideal treatment.The inventor thinks that the rheumatoid arthritis cause can be summarized as " empty, evil, poison " three aspects, and promptly rheumatoid " empty, evil, the poison " cause of disease is said.Void, promptly healthy energy is lost emptyly, is the intrinsic factor that disease takes place, and also is the basic reason of onset, such as congenital defect, impairment caused by overstrain, prolonged illness, day after tomorrow deficiency etc.; Heresy, promptly pathogen derives from nature, is the morbific essential condition of exopathogenic factor, such as pathogenic bacteria, virus, wind, cold, administration, wet, dry, fiery six climate exopathogens, the wetland that hangs up one's hat, underwater work, ice and snow are endured cold, and covet cold hot summer days and blow electric fan, air-conditioning etc. for a long time; Poison, i.e. " expectorant is turbid, deteriorated blood, fire ", be exopathogen invasion human body after, fight the mutually noxious substance of the pathological product that produced of knot of healthy energy and pathogen, it retains in the blood vessel, nowhere less than, specially attack the position of the capable difference of blood, as meridians, joint, muscle, film, chamber, sclerotin etc.Its property viscous can hinder that blood passes unimpeded and the supply of nutrition, excites the recurrence of the state of an illness, increases the weight of the differentiation of the state of an illness, directly destroys the sclerotin joint, causes deadlock in morning, redness and swelling of joints, burning pain, swelling, distortion, until the maimed person.Rheumatoid arthritis development and transformation mechanism: positive before this exogenous pathogen is invaded.Be the damp and hot heresy of wind and cold, behind the invasion and attack human body, vital QI cannot conquer pathogen is sympotoms caused by cold factors just mostly, with the passing of time can be converted into heat symptom-complex, and mixes to seeing with damp and hot the holding under the arm of wind and cold more.Be that heresy is invaded intoxicating again, treating the exterior first and then interior, pathogen invasion and attack flesh table, and then change human body over to, and reach meridians, cause QI-blood circulation not smooth, give birth in blood stasis expectorant is turbid, stagnate through satisfying, inaccessible obstructed, arthromyodynia of a specified duration increases the weight of to worsen.Rheumatoid arthritis is to be the special arthromyodynia of the cause of disease with " real deficiency with pseudo-excess ", " deficiency and excess is held under the arm assorted ", and is completely different with the arthromyodynia of " wind and cold is wet " three gas random thoughts.The inventor thinks that " empty, evil, poison " is the cause of disease of rheumatoid arthritis, and " real deficiency with pseudo-excess " then is the old complaint of rheumatoid arthritis.Therefore, must break traditional over the past thousands of years idea in treatment, take dialectically to combine with debating disease, not be subjected to attack in early days heresy, middle and advanced stage is just set upright; The early stage no stasis of blood stagnates and can not lead to the restriction that stagnates by blood stasis dispelling.Should adhere to " deficiency syndrome should be treated by tonifying method, sthenia syndrome requiring purgation ", no virtual image is not forgotten to consolidate yet, the no stasis of blood stagnates and not to forget also that blood stasis dispelling is logical to stagnate, only improving and strengthening under the prerequisite of patient's autoimmune function, sick just just with setting upright the logical medicine that stagnates of blood stasis dispelling, prevent stagnating of blood vessel meridians in advance, keep the unimpeded of passages through which vital energy circulates, the differentiation and the development of prevention and blocking condition are strangled " exogenous pathogen poison " among rudiment, make the turbid deteriorated blood of expectorant not have the stop of growing part, could treating both the principal and secondary aspects of a disease, reach the purpose of elimination.Say that based on above-mentioned " exogenous pathogen poison " pathology a kind of medicine for the treatment of rheumatoid arthritis of the present invention is to use and develop in conjunction with the repeated screening of modern medicine study achievement through long-term practice.The compound Chinese medicinal preparation medicine that Chinese medicine composition of the present invention selects Radix Ginseng Rubra, Cornu Cervi Degelatinatum, the Rhizoma Atractylodis Macrocephalae, baked polygonum capitatum, Radix Stephaniae Tetrandrae, Radix Tripterygii Wilfordii, Herba Ephedrae, Hirudo, Scolopendra, Natrii Sulfas, Radix Cynanchi Paniculati, Radix Glycyrrhizae combination to make, can make each efficacy of drugs produce synergism, thereby can effectively treat rheumatoid arthritis.
Select for use Radix Ginseng Rubra to be among the side of the present invention because Radix Ginseng Rubra is sweet, warm.Have strongly invigorating primordial QI, multiple arteries and veins takes off the effect of nourishing qi to stop admittedly; Cornu Cervi Degelatinatum Cheng Wen, warming the kidney to activate YANG, the bitter sweet temperature of the Rhizoma Atractylodis Macrocephalae, invigorating the spleen and benefiting QI, the dampness diuretic, the sweet temperature of baked polygonum capitatum, nourishing the liver and kidney, nourishing YIN is enriched blood.More than the pharmacodynamic feature of one group of four Chinese medicine be mainly QI invigorating and enrich blood, nourishing the liver and kidney, bone and muscle strengthening helps the function of strengthening the body resistance altogether.
In order to reach effective treatment, treating both the principal and secondary aspects of a disease, medicine of the present invention also make up with Radix Stephaniae Tetrandrae, Radix Tripterygii Wilfordii, Herba Ephedrae, Hirudo, Scolopendra, Natrii Sulfas.At this moment because Radix Stephaniae Tetrandrae hardship, cold.Has inducing diuresis to remove edema, expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, the effect of parasite killing detoxifcation; The hot temperature of Herba Ephedrae, diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; It is bitter flat, poisonous that Hirudo becomes, removing blood stasis, and removing blood stasis stimulates the menstrual flow; The hot temperature of Scolopendra, poisonous, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; The salty bitter cold of Natrii Sulfas, purging heat to relax the bowels, moistening for dryness and softening hard mass, pathogenic fire purging detumescence.Above Six-element medicine focuses on dredge the meridian passage, dispelling cold and removing dampness, and eliminate stagnation and dissolve phlegm, reducing swelling and alleviating pain is drained pyretic toxicity, and common assistant helps the monarch and his subjects' product dispersing pathogen accumulation, the capable merit that reaches reducing swelling and alleviating pain of unimpeded blood.
In order to obtain optimum curative effect, medicine of the present invention also adds Radix Cynanchi Paniculati, Radix Glycyrrhizae combination on the basis of said medicine.At this moment because of Radix Cynanchi Paniculati suffering, temperature.Has the removing dampness of dispeling the wind, the effect of antalgesic-antipruritic, antiallergic; Radix Glycyrrhizae is sweet flat, in the sweet mitigation, and heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.More than two medicines focus on coordinating the actions of various ingredients in a prescription, alleviate and cushion toxicity and untoward reaction, be aided with the merit of the QI invigorating of detoxifying simultaneously.
This shows, medicine of the present invention makes up 12 flavor medicines among the above-mentioned side, particularly with the described weight proportion combination of prescription, improve that immunologic function, nourishing the liver and kidney, blood stasis dispelling logically stagnate, unimpeded blood is capable, the effect of reducing swelling and alleviating pain, recovery function of joint is stronger, curative effect the best of treatment rheumatoid arthritis.The preferred preparation of recipe drug of the present invention is suited the remedy to the case, and specificity is strong, and treating both the principal and secondary aspects of a disease is evident in efficacy to rheumatoid arthritis, can effectively control rheumatoid arthritis acute stage and active stage, and it is fast to recover function of joint, and once healing, generally is difficult to recurrence.Simultaneously, better to the rheumatism curative effect.
Medicine of the present invention, raw material is easily got, taking convenience.It is for oral administration that medicine of the present invention is pressed the fried one-tenth Chinese medicine decoction of the conventional decocting method of Chinese medicine usually.General patient takes 30 days courses of treatment 30 pairs of Chinese medicines and can cure, and severe patient takes and can be clearly better 2-5 the course of treatment, all can cure mostly, and once healing, be difficult to later on recur.Medicine of the present invention can be made into pill, capsule or soft extract when producing in batches, temporarily called after " strengthening vital QI to eliminate pathogenic factors detoxifcation spirit ".Patient with rheumatoid arthritis people more than 1200 is successively treated in medicine of the present invention clinical practice 29 years, and effective percentage reaches 98%, and cure rate is 91%.Particularly for rheumatoid arthritis early, mid-term the patient, cure rate is up to 99%.But for back, patients with terminal, as dislocate, bone decreases, articular surface merges and lose former joint sign, obvious relief of symptoms, the function that the recovered part joint injury is light reaches the effect of improving partial function, generally still is difficult to thorough healing.
In sum, a kind of medicine for the treatment of rheumatoid arthritis of the present invention has following characteristics: the one, and selected medical material, treating both the principal and secondary aspects of a disease, evident in efficacy.This medicine is screening 12 flavor Chinese medicines in long-term practice is used, and suits the remedy to the case, and specificity is strong, particularly on prescription preparation and treatment theory, breaking conventional conception adopts QI invigorating to enrich blood, and removing blood stasis is logical to stagnate reducing swelling and alleviating pain, treating both the principal and secondary aspects of a disease, the effect uniqueness, and, be difficult to recurrence once healing.The 2nd, taking convenience, quick result.This medicine adopts fried Chinese medicine decoction for oral administration usually, also can be made into pill, capsule or soft extract, relative short treating period, good effect.This medicine adopts the innovative idea of " preventing diseases instead for the treatment of diseases " that strengthen patient's autoimmune function on the basis of curing the disease simultaneously, as long as the treatment patient with rheumatoid arthritis, everybody is effective.For reaching optimum efficiency, clinically also can be according to the weight of the inclined to one side victory of the power of the size of patient age, body constitution, cold and heat, venation obturation and picture of the tongue, pulse condition etc., suitably allocating dosage with the master of decision prescription, help, assist, transfer, reach the disease medicine and be harmonious.The medicine that is former side does not change, and only needs to change the dosage weight of former side's flavour of a drug, just can reach with the same people of Fang Zhi, same disease, the state of an illness in same period.The 3rd, raw material is easily got, promise well.This medicine is common easily to be got, and preparation easily, suitable batch production.Rheumatoid arthritis particularly, Yi Fa and common, and be called " insensitive impediment " in the traditional Chinese medical science, and being difficult to radical cure, the world of medicine does not still have desirable medicine at present.Short treating period of the present invention, good effect, the cure rate height will become the innovative product that market in urgent need is filled a vacancy, and market potential is big, and development prospect is good.
[specific embodiment]
Below further sets forth the beneficial effect of medicine of the present invention by drug test and Drug therapy example, these tests comprise the clinical observation on the therapeutic effect test of medicine of the present invention and specifically treat the case brief introduction.
The clinical observation of [test example 1] Drug therapy rheumatoid arthritis of the present invention
1, basic condition
2000 to 2004, diagnosis and treatment rheumatoid arthritis and ankylosing spondylitis and rheumatism patient 860 examples.Wherein male 238 examples, women 622 examples; Age 8-20 year 84 examples, 21-30 year 88 examples, 31-40 year 172 examples, 41-50 year 430 examples, 51-60 year 90 examples, 82 examples more than 61 years old; Peasant 439 people, workman 120 people, student 172 people, cadre 52 people, teacher 43 people, other 34 people.Early stage 344 people in patient with rheumatoid arthritis, mid-terms 301 people, late periods 129 people, other has ankylosing spondylitis and rheumatism patient 86 people.What the course of disease was the longest reaches 30 years, the shortest only 30 days.
2, diagnostic criteria
To patient with rheumatoid arthritis by medical science by stages universal standard diagnostic classification be in early days, mid-term, late period.
In early days: the overwhelming majority gets involved the joint to swelling and ache and limitation of activity; But the X line only shows soft tissue swelling and osteoporosis.
Mid-term: the function of joint activity of partly getting involved is obviously limited; X-ray film shows that the joint space narrows down and bone corrosion in various degree.
Late period: various deformities appear in the majority joint of getting involved, and fiber is tetanic, movable difficulty, and X-ray film shows the joint heavy damage, dislocation or merge.
3, Therapeutic Method
For oral administration by the fried Chinese medicine decoction of prescription of the present invention.Decoct secondary 1 pair of every day, and the morning and evening are for oral administration, 30 days courses of treatment, treats elder and took continuously five months 150 days, be i.e. 5 courses of treatment.
4, criterion of therapeutical effect
Produce effects: the arthralgia of getting involved after treatment is clearly better or disappears, and function of joint is improved or recovered normal, and RF, ESR recover normal, and can keep more than 3 months after the drug withdrawal.
Take a turn for the better: the arthralgia of getting involved after treatment or swell and ache and take a favorable turn, RF, ESR titre reduce.
Invalid: more than treatment 1-3 the course of treatment (30 days per courses of treatment), the arthralgia of getting involved does not have improvement.
5, therapeutic outcome (see Table 1 and table 2)
Table 1 is observed after treatment rheumatoid arthritis curative effect
Figure GSB00000394760700071
Table 2 is through treating five months to the rheumatoid arthritis observation of curative effect
The rheumatoid arthritis classification In early days Mid-term Late period Other rheumatism
Case before the treatment 344 301 129 86
Treatment back case 0 2 15 0
Total effective rate 100% 99% 88% 100%
Show from table 1 observation of curative effect result, patient with rheumatoid arthritis was being treated 5 months, observe 6 middle of the month, with medicine of the present invention its treatment rheumatoid arthritis people's 860 examples (wherein rheumatism patient 86 examples), produce effects 774 examples as a result, obvious effective rate is 90%, 69 examples that take a turn for the better, improvement rate is 8%, invalid 17 examples, inefficiency is 2%, and total effective rate reaches 98%.
Show from table 2 observation of curative effect result, medicine warp of the present invention is to five months observation of curative effect of rheumatoid arthritis people 860 examples (wherein rheumatism patient 86 examples) treatment, the result is 100% to rheumatoid arthritis early stage patient total effective rate, mid-term, patient's total effective rate was 99%, the patients with terminal total effective rate is 88%, is 100% to rheumatism patient total effective rate.
Further set forth instructions of taking and the preparation method and the therapeutic effect thereof of medicine of the present invention below by embodiment.
The fried Chinese medicine decoction instructions of taking of [instructions of taking 1] medicine of the present invention
Chinese medicine decoction is the liquid preparation that forms through decocting.Medicine of the present invention is assorted by prescription, become the sand jar to decoct with marmite.Wherein Natrii Sulfas does not decoct and treats that medicinal liquid is admixed in the medicinal liquid after fried again and take.During decoction, water will cover powder 2-3 centimetre, treat water boil after, fry in shallow oil again with low baking temperature and to get final product in 50 minutes.When decocting for the second time, the water yield needs only crosses powder slightly, boils to get final product in 45 minutes.Usually take 1 pair every day, should divide the morning and evening secondary after meal half an hour decoction being taken warmly.
[preparation method 1] bolus of drug preparation method of the present invention
12 flavor medicated powder in the pharmaceutical preparation of the present invention are broken into fine powder, sieve, mixing, every 100g powder adds the close 100-160g of refining and makes binding agent, makes honeyed pill with rubbing the ball method with the hands, weighs 13 and restrains, and packs with paraffin paper.In addition, also available water is made binding agent, makes the watered pill with agitation procedure.Cold drying, that is, per 100 nearly weigh 3g.Use the vial splendid attire.
[preparation method 2] medicament capsule preparation method of the present invention
11 flavor medicines (Natrii Sulfas is standby) in the pharmaceutical preparation of the present invention are added water boil twice, add in a small amount at every turn, merge decocting liquid twice, filter gained filtrate, again Natrii Sulfas is admixed in the liquid, be condensed into proportion and be 1.35 extractum not have powder to be advisable.Add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrated.With the capsule vial splendid attire that adopts the Chinese medicine conventional method to make.
[preparation method 3] medicine clear paste agent of the present invention preparation method
11 flavor medicines (Natrii Sulfas is standby) in the pharmaceutical preparation of the present invention are decocted with water twice, and each amount of water was not advisable to have powder, merged decocting liquid twice, filtered gained filtrate, Natrii Sulfas was admixed in the liquid again.Filtrate is condensed into the clear paste of proportion 1.21-1.25 (80-85 ℃ of heat is surveyed).Every 100g clear paste adds red pool 200g, and heating is dissolved, and mixing is concentrated into regulation proportion, promptly.Use the vial splendid attire, airtight, store in shady and cool dry place.
[embodiment 1-5]
Example 1 Hu Fenghua, the woman, 19 years old, married, west, Xinning County, Hunan Province was towards the village people.On June 15th, 1985.Puerperal brothers joint symmetry redness, burning pain shows effect repeatedly, irregular heating 183 days.Be diagnosed as rheumatoid arthritis, through the weary effect of multi-treatment.Its husband draws with car and send prescription on individual diagnosis, pale complexion, body to disappear to urinate, and brothers' arthrodesis is bent the position, and limitation of activity is movingly slightly then cried bitter tears.Look into both hands foot, toe, wrist, elbow, ankle, knee joint swelling, the finger toe is fusiformis and changes, the lower limb muscles atrophy, and knee joint is arthroncus of knee shape.38.9 ℃ of T, heart rate: 128 times/minute, Hb 6.5g, WBC 18.6 * 10 12/ L, ESR 108mmh, the RF positive, X line prompting: all visible obvious swelling of soft tissue of both hands toe wrist elbow ankle knee joint, gap turn narrow, knee joint has transudate, and string overflows property osteoporosis sign.Tongue body is thin, red tender, the yellow and thin fur of matter, dry no Tianjin, deep and weak pulse, stringy and thready pulse number, constipation red urine greatly.
Control survey: doctor trained in Western medicine antiinflammatory, liquid supporting treatment.The traditional Chinese medical science: symptomatic treatment in acute condition, with methods such as clearing away heat-damp and promoting diuresis regulating blood flow to alleviate pains, severe and migratory arthralgia Tonga subtracts, front and back treatment 36 days, though the symptom alleviation, all the time can not disease controlling.The fervescence of suffering from cold continued between 39.5 ℃-40.5 ℃ near day, and the state of an illness also increases the weight of thereupon, and the cooling transfusion also can only be kept 3-4 hour.Check: Hb 5g, WBC 21.5 * 12 12/ L, physical condition is poorer, seldom feed comes for three days on end, delirium lethargy, night joint severe pain and cry and cry endlessly, its husband sees this and leaves without saying good-bye.To this, the state of an illness is critical, and the inventor ruminates over, and lose blood puerperal and cause this disease, anemia, heat is not moved back with antipyretic, and it is tender dark red to scrutinize body of the tongue, and yellow fur does not have Tianjin, and deep and weak pulse, string is puckery counts accurately.Suddenly see the light, this be blood deficiency pyrogenicity also, with the passing of time the inaccessible channel tunnel of the turbid deteriorated blood of expectorant produces pyretic toxicity in addition, deficiency and excess is held under the arm assorted, must rules together by this mark, sets upright, same the executing of eliminating evil, detoxifcation can gather effect.So speed is picked up 3 doses of dense potions of frying in shallow oil of medicine of the present invention and is on the point of clothes,, fed at 8 o'clock in evening as long as can eat not-timely.Private prosecution: dizzy nausea, stomachache, dysphoria, cross and gradually to pacify half an hour approximately and sleep, 1 o'clock of evening makes the rounds of the wards, and sees its sweet sleeping soundly, and sweating is big as Semen Glycines, and survey axil temperature is not all known 37.5 ℃ of T.Show the smile next day, early 6 the time, even if stomachache is successively discharged hard black sheep dung number and picked up piece companion's mucus stench, loose stool is a lot of.Feel that health is brisk, desire is thought food.Behind 5 doses of the continuous clothes, pain, swelling obviously alleviate, obey 15 doses again by former side again after, brothers' function is more preceding flexibly, can the dining of own end bowl, comb one's hair.Along with sb.'s illness took a favorable turn, prescription is still constant, only changes the dosage of its Chinese medicine, and front and back are obeyed 116 doses of this sides altogether, patient's appetite amelioration, body is rich flushing, brothers' swelling is disappeared entirely, joint motion can arrive outdoor activity freely, road return 8 kilometers free and relaxed.Being with money to admit one's mistake after its husband hears the news leaves hospital.Obey again 2 courses of treatment for preventing to recur,, had 20 years now and do not seen recurrence, also give birth to a man and a woman to consolidate curative effect, so far healthy.
Example 2 Long Gang, man, 17 years old, the student, Xinning County, Hunan Province peace Wen Tang people from village, mountain area, first visit on July 6 in 1989, both hands joints of foot symmetrical swelling was shown effect 8 years repeatedly, was diagnosed as rheumatoid arthritis, fail to control through curing the state of an illness in many ways, existing both hands joints of foot is stiff, the fixing position of bending, walking is difficult, can't take care of oneself, discontinued one's studies 2 years, the state of an illness increases the weight of gradually.His father carries on the back out of admiration for a famous person and send prescription on individual diagnosis.Look into: the anemia looks, to become thin, both hands toe toe is fusiformis and changes, two ankle arthroncus of knee joints, the floating patella test positive, the obvious atrophy of juxtra-articular muscle, stiff in stiff 4 hours of morning, overcast and rainyly can continue until afternoon.Hb 7.0g, WBC11.8 * 10 12/ L, ESR 85mmh, the RF positive, the prompting of X line: both hands refer to the obvious swelling of toe elbow wrist knee joint soft tissue, and the joint space narrows down, visible osteoporosis sample changes.Private prosecution: be afraid of cold, dizzy weak, stomach wrist distending pain, pantothenic acid, the red tongue slight of stature is dark violet, and tongue is greasy in vain, and deep and weak pulse is thin, stringy and rolling pulse.
The rule of treatment: after obeying medicine 5 pairs of the present invention, can get on and off, have 2 kilometers roads to help from the station walking to institute.Looking into: obviously disappears in the joint of its swelling, and after continuous clothes 30 pairs, appetite heightens, and symptom further alleviates, and all joint function disturbances are obviously alleviated, and morning, deadlock shortened to 1 hour, and can arrive the playground and beat basketball, waited motion by bike, recovered to go to school.According to existing symptom, increase the dosage of setting upright medicine, withdraw decoction, change honeyed pill into, took medicine continuously 1 year.Winter vacation calendar year 2001, institute was thanked you, and the patient is glowing with health, and limbs are plentiful, tell: stiff disappearance in morning.Check: Hb12g, ESR8mmh, the RF feminine gender, the prompting of X line: gap broadening, do not see that osteoporosis changes.Joint motion freely.Look and treat before relatively become quite a different person.Work.Body is strong so far, does not see discomfort.
Example 3, Chen Guitian, woman, 56 years old, Hunan Province Xin Ning county Lang mountain people from town.On March 21st, 1997 went to a doctor, and patient's both hands foot near-end interphalangeal joint swells and ache, and dysfunction 15 years is diagnosed as rheumatoid arthritis.Fail disease controlling through the Chinese medicine and western medicine multi-treatment, symptom increases the weight of year by year, can't take care of oneself; Soreness of the waist and knees, the aversion to cold cold extremities, limbs fatigue, the spontaneous perspiration of breathing hard is accompanied tachypnea uncomfortable in chest.Look into: the swelling of both hands toe toe joint is fusiformis and changes wrist, elbow, ankle, the equal swelling pain of knee joint, function limitation, the fixing position of bending, anemia is held, cyanotic lips is breathed tachypnea, heart rate 68 times/minute, rule is neat, two lungs are covered with dried moist rale, 38.5 ℃ of Bp 165/98mmHg of T, ESR 69mmh, the RF positive, Hb 8.0g, WBC 13.5 * 10 12/ L, rabat: two lungs strand reason increases thick disorder, and the alveolar gap disappears, and podiod increases.Conclusion: chronic bronchitis companion emphysema, the prompting of X line: two brothers refer to the obvious swelling of toe Wrist elbow joint soft tissue, gap turn narrow, two ankle knee joint soft tissue swellings, the narrow visible osteoporosis calcium in gap takes off sign.The tender modest red tongue of tongue is dark violet, and tongue is greasy in vain, counts constipation, urine swelling pain a little less than the deep-slow pulse accurately.The rule of treatment: after obeying medicine 5 pairs of the present invention, asthma uncomfortable in chest is clearly better, and it is unimpeded to defecate, and brothers are more preceding, and pain subtracts slightly flexibly, and after continuing to obey 15 pairs, brothers' swelling is obviously disappeared, and can oneself have a dinner, and last lavatory not very important person is held up, and can walk lamely at the indoor rod of leaning on.After obeying 30 again, top change dosage changes honeyed pill clothes 1 year into.Come institute's check: stiff disappearance in morning, limb edema disappears entirely, Hp 10.5g, ESR 8mmh, the RF feminine gender, the prompting of X line: the broadening of all joint spaces, calcium takes off disappearance, does not see that bone decreases.Obey 3 months pills again, recovery from illness.Healthy over 7 years, can go up a hill and cut firewood, can choose 100 jin of loads, the productive labor brothers are flexible.
Example 4 Yang Lin, woman, 11 years old, student, Wan Tang township, Xinning County, Hunan Province Bai Matian people from village.First visit on May 23 in 1999 is diagnosed as " subacute allergy septicemia " through the refined Annex II in province Hunan institute, rheumatoid special type arthritis 6 years, the high fever of unknown cause repeatedly, both hands foot swelling deformity 3 years.Long-term hormone therapy.Once going to Wuhan, Guangzhou, Changsha etc. to locate to cure can not disease controlling, and its mother carries on the back out of admiration for a famous person and send prescription on individual diagnosis.Look into: anemia holds; Skinny, costa sternales appears, the soft deflation of abdominal muscle, rarely seen extremities joint enlargement deformity, amyotrophy, refreshing know, in a trance, order eyeball semi-closure partly opens extremely feeble.39.8 ℃ of T, neat 135 times/minute of the rhythm of the heart, Hb 5.0g, WBC 25.6 * 10 12/ L, ESR 136mmh, the RF positive, the prompting of X line: both hands toe toe wrist elbow ankle knee joint is all seen soft tissue swelling, gap turn narrow, the casual property osteoporosis sign of visible string.Now obey the hormone profuse sweating of then having a stomachache and drench drop.Stop hormone and then generate heat and do not move back, persistent fever is 186 days, and the critical state of an illness is very thorny.Its mother says that the present seeks medical advice out of admiration for a famous person, if the conscientious treatment of doctor, the not strange doctor of accident, professional ethics, which has the reason of seeing someone in mortal danger without lifting a finger to save him.Scrutinize corpulent tongue greatly profusely, the dark tongue quality purple is tender, and there is the tooth seal on the limit, and tongue is white thick greasy, halitosis, and the stool first quarter moon is not in a position to once, the red urine burning pain, the deep pulse onion is thin and delicate.Advise and feed, have many meals but little food at eath with congee milk powder.
The rule of treatment: it is difficult to begin to take medicine, preceding 4 days body temperature as before, obey to medicine of the present invention about the 5th day 3 o'clock of night, stomachache is cry and screamed, and vomits about 250 milliliters more than of white thickness sputum repeatedly, the thickness difficulty is taken off, the back stool has been discharged ten pieces of the hard sheep dung of black granule numbers, and stench is unpleasant, pale complexion, profuse sweating drenches drop, and the bed that falls is just slept.Inferior morning, body temperature was 37.5 ℃, and it is clear to think the Eating God, and is sick strong, imitates more not just, takes medicine altogether after 306 pairs, and body temperature just settles out, keep 37 ℃ constant.Disappear in the joint of alleviation of pain swelling.Face has color, and appetite strengthens, and stool urine recovers normal, can wear the clothes, and squats down, and upper and lower stair, and can arrive outdoor stroll, activity can help to sweep the floor, and make a fire and make meal, and housework such as feed pigs.For consolidating curative effect, advise again continue clothes medicine-feeding 30 pairs after, swelling disappears entirely, the return 6 kilometers hill paths of going to school are free and relaxed.For the Reduction of Students' Study Load load, change into and obey 5 auxiliary medicines (former side) January, continued 1 year.2002, drug withdrawal in the Spring Festival, healthy, cause heating after drenching with rain on July 3rd, 2004 because of going to school, continue not move back in 7 days, infuse No. 5, the cephalosporin of red doctor in the locality, the every day of intramuscular injection sooner or later peace is quiet each 1 and does not all bring down a fever, there is slight redness in the brothers joint, and companion's dysfunction is gone to a doctor by its female back of the body again.
Look into: T40.5 ℃, Hb8g, WBC2500 * 10 12/ ESR68mmh, RF is weak positive, and is continuous by the original dosage in top, and just constant 37 degree of continued treatment 92 days, body temperature are constant, and stiff disappearance the in morning eliminated in swelling.After medicine of the present invention dried to grind incapsulate continuous clothes clothes on March 5th, 4 months 1 constitution.The rich body of body is strong, has rosy cheeks menstrual onset.Study in middle school now, be to it among observation is visited.
Example 5 Ou Yangling, man, 65 years old, Xinning County, the Hunan Province retired cadre of grains bureau.First visit on January 15 in 2000 was made a definite diagnosis rheumatoid arthritis 24 years.Use notes such as hormone, ZHENGQINGFENGTONGNING, Radix Tripterygii Wilfordii tablet, the multiple antiacid enzyme of Serpentis, Herba Saussureae Involueratae, Yun Ke " numbness is grand pacifies clearly ", " misery is to stop " and nonsteroidal anti-inflammatory agent two, medicine such as three-way repeatedly, all fail disease controlling.Be in hospital in county people's hospital and be unable to leave the bed in 118 days.The patient also suffers from hypertension, coronary heart disease, erosive gastritis, the blood vessel of infusing can't be sought for a long time, and arrive the end of the year, and school repeatedly urges leaves hospital.Can only how the patient be unable to leave the bed, and extremity are stiff, cannot move, and its younger brother asks the inventor to go to hospital bed out of admiration for a famous person, see and cure, so that be equipped with its funeral affairs.Look into: T38.7 ℃, Bp165/95mmHg, hear sounds is weak slow, and 65 times/minute, ESR68mmh, the RF positive, Hb6.5g, WBC18.9 * 10 12/ L, the prompting of X line: brothers refer to the obvious swelling of toe joint soft tissue, and the gap is narrow, the visible part dislocation, three dactylus gaps disappear, the knee joint soft tissue swelling, the gap is narrow, and casual property osteoporosis of companion's string and part calcium take off.Moon face, pale complexion, anasarca refers to by as mud, and brothers typical case fusiformis changes, and amyotrophy around the joint is stiff, the fixing position of bending; Corpulent tongue greatly profusely, matter is dark violet, and tooth seal is arranged, tongue is greasy in vain, the deep-slow pulse stringy and rolling pulse.Can cure after looking into, risk is very big.Its younger brother says, and disease so far as long as conscientious treatment is accepted the consequences by oneself if any accident, is lifted with the stretcher four-player and gone home to cure.After obeying medicine 5 pairs of the present invention, swelling disappears for a short time, and heat is moved back alleviation of pain; When clothes to 20 were secondary, edema, swelling disappeared greatly, and oneself can be had a dinner, and the layman helps down can be in indoor limping; After obeying 100 pairs altogether, swelling disappears entirely, and life can be taken care of oneself, but stair activity is practised taijiquan, taken a walk to outdoor.Decoction changes honeyed pill into and makes the big ball of Firmiana platanifolia (Linn. f.) Marsili by former side mushroom powder Mel, each 2 of every day 2 times continues and obeys a year and a half, stiff disappearance in morning.Can make meal, mop the floor, walking comes and goes 6 kilometers does not have discomfort, and flushing body is strong.Drug withdrawal 3 years half now.Check: Hb10.5g, ESR12mmh, RF is weak positive, the prompting of X line: brothers refer to that the toe joint recovery is normal, gap broadening, calcium takes off loose the disappearance, does not see that bone decreases change, also need take medicine by the state of an illness, and the patient tells: take medicine and be afraid of, do not want to eat.The existing overcast and rainy slight discomfort that still has, but through movable and slightly after the massage symptom disappear thereupon.

Claims (2)

1. a medicine for the treatment of rheumatoid arthritis is characterized in that it is to be made by following materials of weight proportions medicine: Radix Ginseng Rubra 8-15g, Cornu Cervi Degelatinatum 10-20g, Rhizoma Atractylodis Macrocephalae 5-25g, baked polygonum capitatum 15-40g, Radix Stephaniae Tetrandrae 10-30g, Radix Tripterygii Wilfordii 8-25g, Herba Ephedrae 5-15g, Hirudo 2-8g, Scolopendra 0.5-2g, Natrii Sulfas 1-10g, Radix Cynanchi Paniculati 10-30g, Radix Glycyrrhizae 5-15g.
2. a kind of medicine for the treatment of rheumatoid arthritis according to claim 1 is characterized in that each raw material preferred weight proportioning is: Radix Ginseng Rubra 10g, Cornu Cervi Degelatinatum 10g, Rhizoma Atractylodis Macrocephalae 20g, baked polygonum capitatum 20g, Radix Stephaniae Tetrandrae 15g, Radix Tripterygii Wilfordii 15g, Herba Ephedrae 6g, Hirudo 6g, Scolopendra 3g, Natrii Sulfas 6g, Radix Cynanchi Paniculati 15g, Radix Glycyrrhizae 6g.
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US20110212198A1 (en) * 2008-09-04 2011-09-01 Academishsch Ziekenhuis Bij de Universiteit van Amsterdam Hangover relief by compositions comprising oral rehydration solution
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CN104399044A (en) * 2014-12-01 2015-03-11 郑州后羿制药有限公司 Traditional Chinese veterinary medicine for treating arthritis, rheumatoid arthritis and osteoproliferation
CN104606545A (en) * 2015-01-29 2015-05-13 张文强 Traditional Chinese medicine composition for treating arthritis caused by rheumatic fever and preparation method thereof
CN113750090A (en) * 2020-06-03 2021-12-07 司正仕 New application of penicillin G sodium salt

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CN1320445A (en) * 2001-03-24 2001-11-07 魏书箱 Chinese-medicinal pill for treating rheumatoid arthritis

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