CN102580030A - External traditional Chinese medicine composition having effect of reducing blood sugar, preparation prepared from the external traditional Chinese medicine composition, and their preparation method - Google Patents
External traditional Chinese medicine composition having effect of reducing blood sugar, preparation prepared from the external traditional Chinese medicine composition, and their preparation method Download PDFInfo
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Abstract
The invention discloses an external traditional Chinese medicine composition having an effect of reducing blood sugar, a preparation prepared from the external traditional Chinese medicine composition, and their preparation method. The external traditional Chinese medicine composition having an effect of reducing blood sugar comprises: by weight, 1 to 6 parts of cassia bark, 1 to 5 parts of dry ginger, 2 to 8 parts of suncured ginseng, 2 to 8 parts of dendrobium, 2 to 12 parts of rhizoma atractylodis, 1 to 5 parts of fructus evodiae, 1 to 5 parts of fructus amomi, 1 to 3 parts of clove, and 1 to 3 parts of semen brassicae. Through external use, the preparation prepared from the external traditional Chinese medicine composition can produce good effects of reducing blood sugar, and solves the problem that the existing western medicine and the existing traditional Chinese medicine for treating diabetes are metabolized by the liver thus producing the damage on a human body. A result of a clinical test shows that through combining oral hypoglycemic western medicines or insulin injections, the preparation prepared from the external traditional Chinese medicine composition can effectively reduce a use amount of a western medicine, gradually produces effects of reducing blood sugar and a use amount of a western medicine, is safe and reliable, and reduces the western medicine dependence of patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition with blood sugar lowering effect, preparation and preparation method thereof.
Background technology
Diabetes (diabetes) are to act on that body causes hypoinsulinism, insulin resistant etc. and a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors or the like various virulence factors; Be main feature clinically with the hyperglycemia; Performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin; I.e. " three-many-one-little " symptom; Diabetes (blood glucose) cause complication in case control bad meeting, cause the depleted pathological changes at positions such as kidney, eye, foot, and can't cure.
At present diabetes prevalence grows with each passing day, and mainly is insulin injection or oral promotion insulin secretion and the medicine that reduces insulin resistant to the treatment of diabetics.Doctor trained in Western medicine insulin and integrative therapy diabetes respectively have length, are that secondary lost efficacy though simple western medicine treatment has easy drug resistance, and side effect such as stomach discomfort, erythra because of its hypoglycemic effect is rapid, is convenient to take or is used and taken like a shot by the patient.Simple treatment by Chinese herbs, though have no adverse reaction, and the generation of may command clinical symptoms and complication; But blood sugar reducing function is slow, and dynamics is less, only therapy of combining Chinese and Western medicine; Both can improve clinical symptoms, prevent and treat complication, and can avoid the untoward reaction of medicine and secondary to lose efficacy again.
Therefore, can be used in combination with Western medicine and have no adverse reaction at present and eutherapeutic Chinese medicine preparation is the focus that those skilled in the art study.But oral Preparation absorbs liver metabolism through gastrointestinal, all more or less has certain toxic and side effects, so eutherapeutic external preparation is inventor's a research emphasis.
Summary of the invention
The objective of the invention is to propose a kind of can the associating use or use, have the external medicine composition of effect of lowering blood sugar with Western medicine.
Second purpose of the present invention is to propose the method for preparing and the most preferred dosage form of above-mentioned Chinese medicine composition.
The first inventor Zhang Runqi doctor of the present invention, four more than ten years of taking up a job as a doctor, at the beginning of taking part in Taoism both the self-passing on of traditional Chinese medical science famous expert Li Zheng, eager to learn because of its natural endowment, smart diligent tireless; And receive liking of name among the people traditional Chinese medical science doctor Su Zhixuan (" reviving one time " doctor Lao Su that common people's public praise is told from mouth to mouth with approbation) deeply, and formally receive and be disciple, from then on master and apprentice two people are together morning and night; Learn and pass on the art industry; Moral becomes skill smart, and teacher people and clay figurine are not doublely got the chief.Zhang Runqi doctor has made creative contribution in R&D process of the present invention; After doctor Zhang Runqi was dead in 2011, attendes Zhao chief physician of China-Japan Friendship Hospital east doctor on the basis of initial research of the present invention and further put in order, study and improve, remedied the deficiency of original formulation; Draw final scheme of the present invention; Thereby produce brand-new exterior-applied formulation, make the patient can break away from the misery of the side effect of taking medicine, the dependence that alleviates the orally-taken blood sugar reducing medicine; And long-term orally-taken blood sugar reducing medicine is to the probability infringement that health causes, and reaches progressively blood sugar lowering and make its purpose of rehabilitation gradually of auxiliary patient.Zhao east doctor is engaged in tcm clinical and studies more than 20 year, and Senile disease is had its original opinion, is good at senile cardiovascular and cerebrovascular disease of treatment and diabetes, and is particularly quite effective aspect the Chinese medicine diabetes.
The present invention selects Cortex Cinnamomi, Rhizoma Zingiberis, Radix Ginseng, Herba Dendrobii, Rhizoma Atractylodis, Fructus Evodiae, Fructus Amomi, Flos Caryophylli, Semen Sinapis Albae nine flavor medicine combinations for use, is prepared into external preparation and can plays effect in reducing blood glucose, unites result of use more with Western medicine.The effect of the said medicine of respectively distinguishing the flavor of is following:
Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet.Gui Jing: return kidney, spleen, the heart, Liver Channel.Function: it is supporing yang to mend fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, the cold extremities faint pulse, the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, the amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor are hot, and are hot in nature.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.
Radix Ginseng: practise and claim " Rhizoma Zingiberis Recens is sun-dried ", in ground, dig out clean drying, be " Radix Ginseng "; The source is the dry root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..Can be used for that weak body and prostration, dyspnea with shortness of breath, spontaneous perspiration limb are cool, tired mind, lack of appetite and vomiting, dyspnea due to deficiency of vital energy or chronic cough, thirst due to body fluid deficiency, insomnia and dreamful sleep, palpitation with fear are forgetful, the disease of sexual impotence, frequent micturition, all qi-blood-body fluid deficiencies.
Herba Dendrobii: another name: Herba Dendrobii, Shi Lan, bracketplant, Dendrobium nobile, maple bean.Nature and flavor are sweet, cold nature.The ability replenishing YIN and removing heat, reinforcing stomach reg fluid.
Rhizoma Atractylodis: nature and flavor are hot, bitter, temperature.Return spleen, stomach, Liver Channel.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness; The asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention.
Fructus Evodiae: another name: bent medicine, volt spicy, peppery, the smelly lake of tea.Hot in nature, acrid in the mouth, hardship.Function: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be used for headache, colic, beriberi, dysmenorrhea, abdominal distention, vomiting acid regurgitation, aphtha.
Fructus Amomi: nature and flavor: acrid in the mouth, warm in nature.Return spleen channel, stomach warp, kidney channel.Function: the removing dampness appetizing, warming spleen and stopping diarrha, it is antiabortive to regulate the flow of vital energy.Cure mainly: be used for turbid damp obstructing in middle-JIAO, the gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Flos Caryophylli: property is hot, temperature.Go into stomach, spleen, kidney channel.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.
Semen Sinapis Albae: another name: hot food.Nature and flavor are hot, heat.Go into meridian of Hand-TAI YIN.Function: warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.Cure mainly: be used for cold-phlegm and breath with cough, distending pain in the chest and hypochondrium, the expectorant meridians that stagnate, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.
In order to realize the object of the invention, the present invention adopts following concrete technical scheme:
A kind of external medicine composition with effect of lowering blood sugar, said Chinese medicine composition is processed by following weight parts proportion raw material medicine:
Cortex Cinnamomi 1-6 part, Rhizoma Zingiberis 1-5 part, Radix Ginseng 2-8 part, Herba Dendrobii 2-8 part, Rhizoma Atractylodis 2-12 part, Fructus Evodiae 1-5 part, Fructus Amomi 1-5 part, Flos Caryophylli 1-3 part, Semen Sinapis Albae 1-3 part.
Each crude drug optimum weight part proportioning of said Chinese medicine composition is:
2 parts of Cortex Cinnamomis, 1 part of Rhizoma Zingiberis, 2 parts of Radix Ginseng, 2 parts of Herba Dendrobiis, 2 parts of Rhizoma Atractylodis, 1 part of Fructus Evodiae, 2 parts of Fructus Amomis, 2 parts of Flos Caryophyllis, 2 parts of Semen Sinapis Albaes.
A kind of external Chinese medicine extract with effect of lowering blood sugar, said extract are extracted through conventional Chinese medicine extraction method by described Chinese medicine composition and obtain.
The purposes of described Chinese medicine extract in preparation blood sugar lowering Chinese medicine for outer use.
A kind of Chinese medicine for outer use with effect of lowering blood sugar, said Chinese medicine preparation is processed by acceptable auxiliary on said Chinese medicine composition and the pharmaceutics.
Said Chinese medicine for outer use is external pulvis or emplastrum.
A kind of method for preparing said Chinese medicine composition, said method step is following:
(1) take by weighing each crude drug according to above-mentioned consumption, subsequent use;
(2) each crude drug is dried, mixed grinding is crossed the 100-200 mesh sieve to Powdered;
(3) packing gets final product.
Cross 100 mesh sieves in the said step (2).
What said method prepared is external pulvis.
The method for using that external pulvis of the present invention is recommended is: the SHENQUE acupoint of applying ointment or plaster, be about to outside the present invention the medical adhesive-bonded fabric bag of packing into powder 10g-15g, and non-woven bag directly is applied to around the umbilicus, suitably to fix, use continuously more than 12 hours every day.
Formulation principle of the present invention and use principle:
Chinese medicine is attached great importance to the umbilicus position of human body, claims that it is " Shenque ".Shenque has another name called: " umbilical cord ", Qizhong, Qishe, Huan Gu, dimension meeting are commonly called as " navel "." can first science of acupuncture and moxibustion " says when explaining its physiological location, characteristic: the Shenque person, god's house is in wherein also, on sky portion then, in be people portion; Umbilicus occupies the center, and is like the rank of nobility of door, magic congenital.God fall because of its about the person, about the middle part, be " between two parties upright the utmost point ", be total pivot that ascending or descending movement of vital Qi is come in and gone out, so can divide pure and impure and other negative and positive, excite the generation and the operation of internal organs passages through which vital energy circulates QI and blood.Dissecting credit from the modern times analyses: umbilical part is near the abdominal cavity, and skin is relatively thin tenderer, and neural blood vessel enriches and has characteristics such as sensitivity height, penetration is strong, absorption is fast.Umbilicus is the last closed place of stomach wall in embryo development procedure, and horny layer of epidermis is the thinnest, and barrier function is relatively poor, and fat-free mass under the umbilicus, and the skin fascia directly links to each other with peritoneum, so penetration is strong.The present invention utilizes ten medicines to carry out being prepared into external pulvis behind the compatibility or emplastrum is used for the umbilicus position, absorbs administration through skin.
Beneficial effect of the present invention:
Preparation external of the present invention has good effect of lowering blood sugar, and has overcome the Western medicine of existing treatment diabetes and the infringement that Chinese medicine causes human body through liver metabolism.And draw through clinical verification, the present invention unites the Therapeutic Method of doctor trained in Western medicine OHA or injection of insulin administration, can reduce the Western medicine consumption effectively, plays the effect that subtracts the medicine blood sugar lowering gradually, and the present invention is safe and reliable, has alleviated the drug dependence of patient to Western medicine.
The specific embodiment
The used medical material of present embodiment all can meet 2005 editions one ministerial standards of Pharmacopoeia of People's Republic of China available from Chinese Medicinal Materials Co.
The preparation of embodiment 1 external pulvis of the present invention
(1) take by weighing each crude drug according to following proportioning, subsequent use;
Cortex Cinnamomi 2g, Rhizoma Zingiberis 1g, Radix Ginseng 2g, Herba Dendrobii 2g, Rhizoma Atractylodis 2g, Fructus Evodiae 1g, Fructus Amomi 2g, Flos Caryophylli 2g, Semen Sinapis Albae 2g.
(2) each crude drug is dried, mixed grinding is crossed 100 mesh sieves to Powdered;
(3) packing gets final product.
The preparation of embodiment 2 external pulvis of the present invention
(1) take by weighing each crude drug according to following proportioning, subsequent use;
Cortex Cinnamomi 1g, Rhizoma Zingiberis 5g, Radix Ginseng 4g, Herba Dendrobii 6g, Rhizoma Atractylodis 8g, Fructus Evodiae 5g, Fructus Amomi 1g, Flos Caryophylli 3g, Semen Sinapis Albae 1g.
(2) each crude drug is dried, mixed grinding is crossed 200 mesh sieves to Powdered;
(3) packing gets final product.
The preparation of embodiment 3 external pulvis of the present invention
(1) take by weighing each crude drug according to following proportioning, subsequent use;
Cortex Cinnamomi 6g, Rhizoma Zingiberis 3g, Radix Ginseng 8g, Herba Dendrobii 8g, Rhizoma Atractylodis 12g, Fructus Evodiae 2g, Fructus Amomi 5g, Flos Caryophylli 1g, Semen Sinapis Albae 3g.
(2) each crude drug is dried, mixed grinding is crossed 200 mesh sieves to Powdered;
(3) packing gets final product.
The preparation of embodiment 4 emplastrumes of the present invention
Method for preparing:
It is subsequent use to press following consumption weighting raw materials, adds the alcohol reflux of 50%-90%, reclaims extracting solution, crosses 120 order stainless steel sifts and filters; In vacuum is 0.07～0.08Mpa, and 70 ℃ of temperature are with extracting solution simmer down to thick paste; Drying makes dry extract; Pulverize, cross 100 mesh sieves, process active component of the present invention; Get rubber, clean, at 50～60 ℃ of heat dryings or dry, be cut into bulk; In rubber mixing machine, plasticating reticulates thin slice, eliminates static after 18～24 hours, is dipped in an amount of gasoline, treats to move in the adhesive supplier after the swelling; Stir, gradation adds vaseline, lanoline, zinc oxide and Colophonium etc. and processes substrate, adds medicine activity component of the present invention etc. again, stirs; Be coated with cream, the lid lining, section promptly makes finished product.
Crude drug and consumption:
Cortex Cinnamomi 2g, Rhizoma Zingiberis 1g, Radix Ginseng 2g, Herba Dendrobii 2g, Rhizoma Atractylodis 2g, Fructus Evodiae 1g, Fructus Amomi 2g, Flos Caryophylli 2g, Semen Sinapis Albae 2g.
Clinical trial of the present invention and result
Clinical data:
1.1 material
Observe 30 routine cases altogether, be the traditional Chinese medical science Diabetes Clinic patient of the court.Male's 12 examples wherein, women's 18 examples, year at age (40～70), the course of disease (6～20) year.
1.2 diagnostic criteria
Western medicine diagnose standard reference The World Health Organization (WHO) in 1999 expert consulting report: fasting glucose >=7.0mmol/L; Or clothes sugar back 2h blood glucose >=11.1mmol/L in the carbohydrate tolerance test; Or the patient of random blood sugar >=11.1mmol/L goes into the anthology experiment.
1.3 Therapeutic Method
All case is up to standard according to conventional hypoglycemic medicine (OHA acarbose, metformin hydrochloride, Gliclazide sustained-release tablet and/or the insulin) blood sugar control of using of blood sugar level.Continue conventional Western medicine glucose-lowering treatment during the treatment, the external pulvis of the dual-purpose embodiment of the invention 1 preparation is packed into and is sticked umbilicus, 24 hours (or being no less than 12 hours every day) in the non-woven bag.
1.4 judgment criteria
Effectively: orally-taken blood sugar reducing dose or insulin injection amount reduce, and glycemic control is steady.
Invalid: orally-taken blood sugar reducing dose or insulin injection amount reduce, blood sugar increasing.Or glycemic control is stable, but orally-taken blood sugar reducing dose or insulin injection amount no change.
1.5 observation of curative effect
After experiment 1 month, OHA or insulin injection glucose-lowering treatment person are under the glycemic control good situations, and medication decrement person reaches 24 people; Effective percentage reaches 80%; Rapid-action, one month promptly effective in cure, explains that the present invention and Western medicine are united to use when good effect of lowering blood sugar is arranged; Reduced the consumption of oral western medicine, avoided infringement and other side effect the human liver.
Claims (9)
1. the external medicine composition with effect of lowering blood sugar is characterized in that, said Chinese medicine composition is processed by following weight parts proportion raw material medicine:
Cortex Cinnamomi 1-6 part, Rhizoma Zingiberis 1-5 part, Radix Ginseng 2-8 part, Herba Dendrobii 2-8 part, Rhizoma Atractylodis 2-12 part, Fructus Evodiae 1-5 part, Fructus Amomi 1-5 part, Flos Caryophylli 1-3 part, Semen Sinapis Albae 1-3 part.
2. the external medicine composition with effect of lowering blood sugar according to claim 1 is characterized in that, said Chinese medicine composition is processed by following weight parts proportion raw material medicine:
2 parts of Cortex Cinnamomis, 1 part of Rhizoma Zingiberis, 2 parts of Radix Ginseng, 2 parts of Herba Dendrobiis, 2 parts of Rhizoma Atractylodis, 1 part of Fructus Evodiae, 2 parts of Fructus Amomis, 2 parts of Flos Caryophyllis, 2 parts of Semen Sinapis Albaes.
3. the external Chinese medicine extract with effect of lowering blood sugar is characterized in that, said extract is extracted through conventional Chinese medicine extraction method by claim 1 or 2 described Chinese medicine compositions and obtains.
4. the purposes of the described Chinese medicine extract of claim 3 in preparation blood sugar lowering Chinese medicine for outer use.
5. the Chinese medicine for outer use with effect of lowering blood sugar is characterized in that, said Chinese medicine preparation is processed by acceptable auxiliary on claim 1 or 2 said Chinese medicine compositions and the pharmaceutics.
6. Chinese medicine preparation according to claim 5 is characterized in that, said Chinese medicine for outer use is external pulvis or emplastrum.
7. method for preparing claim 1 or 2 said Chinese medicine compositions is characterized in that said method step is following:
(1) take by weighing each crude drug according to claim 1 or 2, subsequent use;
(2) each crude drug is dried, mixed grinding is crossed the 100-200 mesh sieve to Powdered;
(3) packing gets final product.
8. method according to claim 7 is characterized in that, crosses 100 mesh sieves in the said step (2).
9. method according to claim 8 is characterized in that, what said method prepared is external pulvis.
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| CN104873949A (en) * | 2015-06-19 | 2015-09-02 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treating old dampness accumulation pattern diabetic foot ulcer |
| CN105079660A (en) * | 2015-09-21 | 2015-11-25 | 蒋丁贵 | Traditional Chinese medicine for treating diabetes and preparation method thereof |
| CN107184838A (en) * | 2017-06-06 | 2017-09-22 | 合肥先智商贸有限责任公司 | A kind of Chinese medicine preparation with effect of lowering blood sugar and preparation method thereof |
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| CN105079660A (en) * | 2015-09-21 | 2015-11-25 | 蒋丁贵 | Traditional Chinese medicine for treating diabetes and preparation method thereof |
| CN107184838A (en) * | 2017-06-06 | 2017-09-22 | 合肥先智商贸有限责任公司 | A kind of Chinese medicine preparation with effect of lowering blood sugar and preparation method thereof |
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| CN102580030B (en) | 2013-11-06 |
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