CN101530537A - Formula for treating diabetes mellitus and preparation method thereof - Google Patents

Abstract

The invention discloses a formula for treating diabetes mellitus and a preparation method thereof, the formula consists of ten traditional Chinese medicinal materials of radix hedysari, white paeony root, common yam rhizome, heterophylly falsestarwort root, kudzuvine root, cassia twig, white mustard seed, glossy privet fruit, feather cockscomb seed and motherwort herb, and the formula is prepared into traditional Chinese medicine tablets, pills, granules and capsules by adopting the conventional process method for extracting active ingredients. The comprehensive effect after extracting the active ingredients of the various medicinal materials in the formula is mainly used for treating diabetes mellitus, the effect is significant and the formula has the functions of clearing heat, nourishing yin, nourishing kidney, promoting production of fluid, quenching thirst and so on.

Description

A kind of prescription and method for making thereof for the treatment of diabetes

Technical field

The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of prescription and method for making thereof for the treatment of diabetes.

Technical background

Diabetes are because the h and E factor interaction, cause that absolute or relative hyposecretion of insulin and target tissue cell reduce insulin sensitivity, cause a series of metabolism disorder syndromes such as protein, fat, power and water Xie Zhi, wherein a hyperglycemia is an outstanding feature.Performance such as polyuria, polydipsia, polyphagia can appear in clinical model case, become thin, i.e. " three-many-one-little " symptom.

Diabetes are one of modal chronic diseases.Along with the raising of people's living standard, the increase of aged tendency of population and fat incidence rate, the sickness rate of diabetes is ascendant trend year by year.It can be summarized as following characteristics:

Sickness rate increases year by year, and quickening trend is arranged, and this is relevant with the living habit that people have changed ancestors' maintenances.The one, the change of dietary habit has generally been had enough, and the meat and vegetables proportional imbalance; The 2nd, physical exertion reduces, and gos out by bus, upstairs takes a lift, and the chance of walking has all lost.The 3rd, because social change is fast, people's mental pressure increases, and can not be eased for a long time.

Chronic complicating diseases of diabetes increases sharply.Patient's majority was to be in hospital because of glycemic control is bad in the past, and now substantially all was the diabetics (〉 85% that merges multiple complications).The patient who wherein is associated with severe complications such as resembling blind, apoplexy, neuralgia, mashed foot, renal failure, heart failure is also a lot.

The good patient of glycemic control seldom.Blood glucose is not up to standard for a long time, (HbAlc 〉=7%) is very fearful, because diabetes are exactly each organs and tissues nervus vasculairs especially that damaging human body in the initial several years unawares, if blood glucose can (HbAlc＜7%---energy＜6.5% is better) up to standard for a long time can equally be had good health and a long life with the normal person away from chronic complicating diseases.

Summary of the invention

The object of the invention is to provide a kind of prescription and method for making thereof for the treatment of diabetes, to improve the medication condition of diabetics.

Be achieved through the following technical solutions order of the present invention:

1, the present invention is the Chinese medicine of being made by the following weight proportion raw material:

Radix Hedysari 30-100g Radix Paeoniae Alba 20-80g Rhizoma Dioscoreae 30-100g

Radix Pseudostellariae 10-60g Radix Puerariae 30-100g Ramulus Cinnamomi 10-60g

Semen Sinapis Albae 20-80g Fructus Ligustri Lucidi 10-60g Semen Celosiae 20-80g

Herba Leonuri 10-60g

2, best each the raw material weight proportioning of prescription of the present invention is:

Radix Hedysari 65g Radix Paeoniae Alba 55g Rhizoma Dioscoreae 65g

Radix Pseudostellariae 45g Radix Puerariae 65g Ramulus Cinnamomi 45g

Semen Sinapis Albae 55g Fructus Ligustri Lucidi 45g Semen Celosiae 55g

Herba Leonuri 45g

3, method for making:

(1) get the Radix Paeoniae Alba 1/5 amount, Rhizoma Dioscoreae 1/4 amount, Radix Pseudostellariae 1/3 amount, Radix Puerariae 1/2 amount mixing, be ground into fine powder, stand-by;

(2) get Radix Hedysari and Ramulus Cinnamomi and mix, add 80～100% alcohol heating reflux and extract twice, each 2 hours, collect alcohol extract, filter, decompression filtrate recycling ethanol makes and contains the alcohol amount and reach 50% approximately, and is stand-by;

(3) Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Pseudostellariae, Radix Puerariae and Semen Sinapis Albae, Fructus Ligustri Lucidi, Semen Celosiae, the Herba Leonuri of getting surplus decocts with water three times, and each 1～2 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds the ethanol of equivalent, stirs evenly, leave standstill, precipitation filters.Filtering residue 50% washing with alcohol, washing liquid and filtrate and above-mentioned alcohol extract merge, decompression recycling ethanol, and be concentrated into the thick paste that relative density is 1.35～1.39 (65～85 ℃), after the cold drying, be ground into fine powder, add fine powders such as the above-mentioned Radix Paeoniae Alba, Rhizoma Dioscoreae then, the mixing that sieves, stand-by;

(4) 1. add the magnesium stearate of appropriate amount of starch and 1～3%, make granule, drying, compacting promptly gets tablet in flakes; 2. use water pill, drying, polishing promptly gets the watered pill; 3. add starch or dextrin is an amount of, mixing is used certain density alcohol granulation, and drying is sieved, and makes granule, promptly gets granule; 4. make granule with certain density ethanol, dry below 60 ℃, the adding Pulvis Talci is an amount of, and mixing incapsulates, and promptly gets capsule.

The prescription that relates among the present invention by Radix Hedysari, the Radix Paeoniae Alba etc. totally ten the flavor Chinese crude drugs form, adopted the process of traditional effective component extracting, the Chinese medicinal tablet of making, pill, granule, capsule.Comprehensive function in its utilization side behind each medicinal material extract effective ingredient cures mainly diabetes, and effect is remarkable, has functions such as clearing away heat and nourishing YIN, nourishing kidney promote the production of body fluid, promoting the production of body fluid to quench thirst.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1: a kind of tablet for the treatment of diabetes

[prescription]

Radix Hedysari 65g Radix Paeoniae Alba 55g Rhizoma Dioscoreae 65g

Radix Pseudostellariae 45g Radix Puerariae 65g Ramulus Cinnamomi 45g

Semen Sinapis Albae 55g Fructus Ligustri Lucidi 45g Semen Celosiae 55g

Herba Leonuri 45g

[method for making]

(1) get Radix Paeoniae Alba 11g, Rhizoma Dioscoreae 16g, Radix Pseudostellariae 15g, Radix Puerariae 32g, mix, be ground into fine powder, stand-by;

(2) get Radix Hedysari 65g and Ramulus Cinnamomi 45g, mix, add 80% alcohol heating reflux and extract twice, each 2 hours, collect alcohol extract, filter, decompression filtrate recycling ethanol makes and contains the alcohol amount and reach 50% approximately, and is stand-by;

(3) get the Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Pseudostellariae, Radix Puerariae and Semen Sinapis Albae 55g, Fructus Ligustri Lucidi 45g, Semen Celosiae 55g, the Herba Leonuri 45g of surplus, decoct with water three times, each 1～2 hour, collecting decoction, filter, filtrate is concentrated in right amount, put cold, the ethanol of adding equivalent, stir evenly, leave standstill, precipitation filters.Filtering residue 50% washing with alcohol, washing liquid and filtrate and above-mentioned alcohol extract merge, decompression recycling ethanol, and be concentrated into the thick paste that relative density is 1.38 (80 ℃), after the cold drying, be ground into fine powder, add fine powders such as the above-mentioned Radix Paeoniae Alba, Rhizoma Dioscoreae then, the mixing that sieves, stand-by;

(4) add the about 2.2g of magnesium stearate of the about 105g of starch and 1%, make granule, drying is pressed into 1000, promptly.

Embodiment 2: a kind of pill for the treatment of diabetes

[prescription]

Radix Hedysari 85g Radix Paeoniae Alba 75g Rhizoma Dioscoreae 85g

Radix Pseudostellariae 55g Radix Puerariae 85g Ramulus Cinnamomi 55g

Semen Sinapis Albae 75g Fructus Ligustri Lucidi 55g Semen Celosiae 75g

Herba Leonuri 55g

[method for making]

(1) get Radix Paeoniae Alba 15g, Rhizoma Dioscoreae 21g, Radix Pseudostellariae 18g, Radix Puerariae 42g, mix, be ground into fine powder, stand-by;

(2) get Radix Hedysari 85g and Ramulus Cinnamomi 55g and mix, add 90% alcohol heating reflux and extract twice, each 2 hours, collect alcohol extract, filter, decompression filtrate recycling ethanol makes and contains the alcohol amount and reach 50% approximately, and is stand-by;

(3) get the Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Pseudostellariae, Radix Puerariae and Semen Sinapis Albae 75g, Fructus Ligustri Lucidi 55g, Semen Celosiae 75g, the Herba Leonuri 55g of surplus, decoct with water three times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated in right amount, put cold, the ethanol of adding equivalent, stir evenly, leave standstill, precipitation filters.Filtering residue 50% washing with alcohol, washing liquid and filtrate and above-mentioned alcohol extract merge, decompression recycling ethanol, and be concentrated into the thick paste that relative density is 1.35 (65 ℃), after the cold drying, be ground into fine powder, add fine powders such as the above-mentioned Radix Paeoniae Alba, Rhizoma Dioscoreae then, the mixing that sieves, stand-by;

(4) use water pill, drying, polishing, promptly.

Embodiment 3: a kind of granule for the treatment of diabetes

[prescription]

Radix Hedysari 100g Radix Paeoniae Alba 80g Rhizoma Dioscoreae 100g

Radix Pseudostellariae 60g Radix Puerariae 100g Ramulus Cinnamomi 60g

Semen Sinapis Albae 80g Fructus Ligustri Lucidi 60g Semen Celosiae 80g

Herba Leonuri 60g

[method for making]

(1) get Radix Paeoniae Alba 16g, Rhizoma Dioscoreae 25g, Radix Pseudostellariae 20g, Radix Puerariae 50g, mix, be ground into fine powder, stand-by;

(2) get Radix Hedysari 100g and Ramulus Cinnamomi 60g, mix, add 85% alcohol heating reflux and extract twice, each 2 hours, collect alcohol extract, filter, decompression filtrate recycling ethanol makes and contains the alcohol amount and reach 50% approximately, and is stand-by;

(3) get the Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Pseudostellariae, Radix Puerariae and Semen Sinapis Albae 60g, Fructus Ligustri Lucidi 60g, Semen Celosiae 80g, the Herba Leonuri 60g of surplus, decoct with water three times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into about 250ml, put cold, adding ethanol 250ml, stir evenly, leave standstill, precipitation filters.Filtering residue washs with 50% alcohol, and washing liquid and filtrate and above-mentioned alcohol extract merge, decompression recycling ethanol, and be concentrated into the thick paste that relative density is 1.35 (80 ℃), and after the cold drying, be ground into fine powder, add fine powders such as the above-mentioned Radix Paeoniae Alba, Rhizoma Dioscoreae then, the mixing that sieves, stand-by;

(4) add the about 180g of starch, mixing, the alcohol granulation with 85%, drying is sieved, and makes granule, promptly.

Embodiment 4: a kind of capsule for the treatment of diabetes

[prescription]

Radix Hedysari 30g Radix Paeoniae Alba 20g Rhizoma Dioscoreae 30g

Radix Pseudostellariae 10g Radix Puerariae 30g Ramulus Cinnamomi 10g

Semen Sinapis Albae 20g Fructus Ligustri Lucidi 10g Semen Celosiae 20g

Herba Leonuri 10g

[method for making]

(1) get Radix Paeoniae Alba 4g, Rhizoma Dioscoreae 7.5g, Radix Pseudostellariae 3.3g, Radix Puerariae 15g, mix, be ground into fine powder, stand-by;

(2) get Radix Hedysari 30g and Ramulus Cinnamomi 10g, mix, add 90% alcohol heating reflux and extract twice, each 2 hours, collect alcohol extract, filter, decompression filtrate recycling ethanol makes and contains the alcohol amount and reach 50% approximately, and is stand-by;

(3) get the Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Pseudostellariae, Radix Puerariae and Semen Sinapis Albae 20g, Fructus Ligustri Lucidi 10g, Semen Celosiae 20g, the Herba Leonuri 10g of surplus, decoct with water three times, each 1 hour, collecting decoction, filter, filtrate is concentrated into about 80ml, put cold, adding ethanol 80ml, stir evenly, leave standstill, precipitation filters.Filtering residue 50% washing with alcohol, washing liquid and filtrate and above-mentioned alcohol extract merge, decompression recycling ethanol, and be concentrated into the thick paste that relative density is 1.38 (70 ℃), after the cold drying, be ground into fine powder, add fine powders such as the above-mentioned Radix Paeoniae Alba, Rhizoma Dioscoreae then, the mixing that sieves, stand-by;

(4) make granule with 90% ethanol, dry below 60 ℃, add the about 24g of Pulvis Talci, mixing incapsulates, promptly.

Claims (4)

1, a kind of prescription for the treatment of diabetes is characterized in that it comprises that weight is that raw material is formed by the following Chinese crude drug of g:

Radix Hedysari 30-100g Radix Paeoniae Alba 20-80g Rhizoma Dioscoreae 30-100g

Radix Pseudostellariae 10-60g Radix Puerariae 30-100g Ramulus Cinnamomi 10-60g

Semen Sinapis Albae 20-80g Fructus Ligustri Lucidi 10-60g Semen Celosiae 20-80g

Herba Leonuri 10-60g.

2, a kind of prescription for the treatment of diabetes as claimed in claim 1 is characterized in that the weight g proportioning of this prescription is:

Radix Hedysari 65g Radix Paeoniae Alba 55g Rhizoma Dioscoreae 65g

Radix Pseudostellariae 45g Radix Puerariae 65g Ramulus Cinnamomi 45g

Semen Sinapis Albae 55g Fructus Ligustri Lucidi 45g Semen Celosiae 55g

Herba Leonuri 45g.

3,, it is characterized in that the method for making of being made Chinese medicine by this prescription is as the described a kind of prescription for the treatment of diabetes of claim 1-2:

(1) get the Radix Paeoniae Alba 1/5 amount, Rhizoma Dioscoreae 1/4 amount, Radix Pseudostellariae 1/3 amount, Radix Puerariae 1/2 amount mixing, be ground into fine powder, stand-by;

(2) get Radix Hedysari and Ramulus Cinnamomi and mix, add 80～100% alcohol heating reflux and extract twice, each 2 hours, collect alcohol extract, filter, decompression filtrate recycling ethanol makes and contains the alcohol amount and reach 50% approximately, and is stand-by;

(3) Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Pseudostellariae, Radix Puerariae and Semen Sinapis Albae, Fructus Ligustri Lucidi, Semen Celosiae, the Herba Leonuri of getting surplus decocts with water three times, and each 1～2 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds the ethanol of equivalent, stirs evenly, leave standstill, precipitation filters.Filtering residue 50% washing with alcohol, washing liquid and filtrate and above-mentioned alcohol extract merge, decompression recycling ethanol, and be concentrated into the thick paste that relative density is 1.35～1.39 (65～85 ℃), after the cold drying, be ground into fine powder, add fine powders such as the above-mentioned Radix Paeoniae Alba, Rhizoma Dioscoreae then, the mixing that sieves, stand-by;

(4) 1. add the magnesium stearate of appropriate amount of starch and 1～3%, make granule, drying, compacting promptly gets tablet in flakes; 2. use water pill, drying, polishing promptly gets the watered pill; 3. add starch or dextrin is an amount of, mixing is used certain density alcohol granulation, and drying is sieved, and makes granule, promptly gets granule; 4. make granule with certain density ethanol, dry below 60 ℃, the adding Pulvis Talci is an amount of, and mixing incapsulates, and promptly gets capsule.

4, as the described a kind of prescription for the treatment of diabetes of claim 1-3, the dosage form that it is characterized in that making behind the preparation can be tablet, pill, granule, capsule, but is not limited thereto.