CN101524471A - Pharmaceutical composition for treating diabetes and preparation method thereof - Google Patents
Pharmaceutical composition for treating diabetes and preparation method thereof Download PDFInfo
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- CN101524471A CN101524471A CN 200810101423 CN200810101423A CN101524471A CN 101524471 A CN101524471 A CN 101524471A CN 200810101423 CN200810101423 CN 200810101423 CN 200810101423 A CN200810101423 A CN 200810101423A CN 101524471 A CN101524471 A CN 101524471A
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Abstract
The invention relates to a pharmaceutical composition for treating diabetes, which is prepared by trichosanthes root, rhizoma anemarrhenae, yam, astragalus root, dwarf lilyturf turber, shizandra berry, dried rhizome of rehmannia, pumpkin, medlar, tuckahoe, angelica, salvia miltiorrhiza, alisma orientale, sealwort, polygonatum, ebony, eucommia bark, cornus and/or a pharmaceutically acceptable carrier. The invention also relates to a method for preparing the pharmaceutical composition. The pharmaceutical composition has efficacies of enriching yin and nourishing kidney, strengthening spleen and replenishing qi, promoting fluid production to quench thirst and the like, and has obvious therapeutic effect on type II diabetes.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen that is used for the treatment of diabetes, and the preparation method of this drug regimen.
Technical background
Diabetes are a kind of common frequently-occurring diseases, at present nearly 2000-3000 ten thousand diabeticss of China.Up to the present this disease is a kind of can not the radical cure, but the disease that can well control.
Diabetes are because the h and E factor interaction, cause that absolute or relative hyposecretion of insulin and target tissue cell reduce insulin sensitivity, cause a series of metabolism disorder syndromes such as protein, fat, power and water Xie Zhi, wherein a hyperglycemia is an outstanding feature.Performance such as polyuria, polydipsia, polyphagia can appear in clinical model case, become thin, i.e. " three-many-one-little " symptom.
Diabetes are one of modal chronic diseases.Along with the raising of people's living standard, the increase of aged tendency of population and fat incidence rate, the sickness rate of diabetes is ascendant trend year by year.Diabetes reach 2% at the sickness rate of China, and according to statistics, the diabetics made a definite diagnosis of China reaches 4,000 ten thousand, and with annual 1000000 speed increase.Wherein, type 1 diabetes patient accounts for 10%, and the type 2 diabetes mellitus patient accounts for 90%.
The traditional Chinese medical science is thought: diabetes are the visceral dysfunctions based on internal organs such as lung, spleen, kidneys that caused by multiple reason, and with hyperactivity of fire caused by deficiency of YIN, metabolism is not normal to be its ill mechanism, and primary disease belongs to " diabete " category.Show according to interrelated data: the glycosuria patient deficiency of YIN accounts for 100%, the deficiency of vital energy accounts for 90%, suffer from a deficiency of the kidney account for 88.2%, blood stasis accounts for 55%, yang deficiency accounts for 22.7%, and single syndrome is less, majority is a deficiency of both QI and YIN, accounts for 67%.
The traditional Chinese medical science is controlled executing of diabetes and is not to be conceived to blood sugar lowering, but emphasizes determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, the differential diagnosis of diseases medication, and pay attention to whole conditioning.From Chinese medical discrimination, diabetes are based on the deficiency of YIN, and see syndrome of blood stasis more, and think that the unusual of rheological property of blood just arranged before syndrome of blood stasis occurring, and concurrent trunk and microangiopathies are so the treatment of blood circulation promoting and blood stasis dispelling should be carried throughout always.To those deficiency of spleen-QI and stomach-QI, the turbid formation of fat, expectorant in blood, the patient of fat blood stasis arteries and veins also need nurse one's health blood fat.
Studies confirm that many Chinese medicine hypoglycemic activities are stable lasting, its mechanism of action and promotion insulin secretion are improved insulin resistant, promote that glucose utilization is relevant, and the protection islet function is had better action; And have blood fat reducing, fall that blood is glutinous, microcirculation improvement, removing free radical, prevent multiple effect such as vascular endothelial injury, has good curative effect for the generation development that stops diabetic complication, and toxic and side effects is little, safety is good, and comprehensive therapeutic effect and the long-range health that ensures the patient is had positive meaning.
Summary of the invention
One of the object of the invention is to provide a kind of drug regimen that is used for the treatment of diabetes.
Two of the object of the invention is to provide the preparation method of this drug regimen.
Technical scheme of the present invention is on motherland traditional Chinese medicine theory basis, in conjunction with modern Chinese medicine pharmacology and clinical research experience for many years, preferred traditional Chinese herbal medicine develops, and has nourishing kidney yin, invigorating the spleen and benefiting QI, an effect such as quench one's thirst of promoting the production of body fluid, and type ii diabetes is had the obvious treatment effect.
A kind of medicine for the treatment of diabetes and diabetic complication provided by the invention comprises the following weight proportion raw material:
1, prescription (part is a unit of weight)
Radix Trichosanthis 2-20 part Rhizoma Anemarrhenae 2-10 part Rhizoma Dioscoreae 20-50 part
Radix Astragali 20-50 part 10-20 Radix Ophiopogonis part Fructus Schisandrae Chinensis 10-20 part
Radix Rehmanniae 10-30 part Fructus Cucurbitae moschatae 20-30 part Fructus Lycii 10-40 part
PORIA from Yunnan of China 10-30 part Radix Angelicae Sinensis 20-40 part Radix Salviae Miltiorrhizae 10-20 part
Rhizoma Alismatis 2-20 part Rhizoma Polygonati 5-15 part Rhizoma Polygonati Odorati 12-20 part
Fructus Mume 10-20 part Cortex Eucommiae 10-30 part Fructus Corni 10-20 part
Effective ingredient is preferably made by weight by following raw materials according:
30 parts of 5 portions of Rhizoma Dioscoreaes of 10 parts of Rhizoma Anemarrhenaes of Radix Trichosanthis
15 parts of the Radix Astragali 15 parts of Fructus Schisandrae Chinensis, 30 parts of Radix Ophiopogonis
30 parts of 25 parts of Fructus Lycii of 15 portions of Fructus Cucurbitae moschataes of the Radix Rehmanniae
15 parts of 20 parts of Radix Salviae Miltiorrhizaes of 15 parts of Radix Angelicae Sinensis of PORIA from Yunnan of China
15 parts of 10 portions of Rhizoma Polygonati Odorati of 15 parts of Rhizoma Polygonatis of Rhizoma Alismatis
10 parts of 15 parts of Fructus Corni of 12 parts of Cortexs Eucommiae of Fructus Mume
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
(1) get Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis and clean and be ground into fine powder, standby;
(2) Radix Trichosanthis, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Rehmanniae, Fructus Cucurbitae moschatae, Fructus Lycii, PORIA from Yunnan of China, Rhizoma Alismatis, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Mume, the Cortex Eucommiae, Fructus Corni water decoct three times, 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate concentrates, and gets thick paste;
(3) with step (1) gained fine powder and (2) gained thick paste mixing, drying and crushing, and/or pharmaceutically acceptable carrier system granule, tablet, capsule.
Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, tablet, capsule oral administration is used.
Chinese medicine composition of the present invention has nourishing kidney yin, invigorating the spleen and benefiting QI, the effect such as quench one's thirst of promoting the production of body fluid, and type ii diabetes is had the obvious treatment effect.
The specific embodiment:
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicinal composition granules of the present invention
(1) get Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis and clean and be ground into fine powder, standby;
(2) Radix Trichosanthis, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Rehmanniae, Fructus Cucurbitae moschatae, Fructus Lycii, PORIA from Yunnan of China, Rhizoma Alismatis, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Mume, the Cortex Eucommiae, Fructus Corni water decoct three times, 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate concentrates, and gets thick paste;
(3) with step (1) gained fine powder and (2) gained thick paste mixing, drying and crushing adds dextrin, lactose, with 75% ethanol wet granulation promptly.
Embodiment 2: Chinese medicinal composition capsules agent of the present invention
(1) get Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis and clean and be ground into fine powder, standby;
(2) Radix Trichosanthis, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Rehmanniae, Fructus Cucurbitae moschatae, Fructus Lycii, PORIA from Yunnan of China, Rhizoma Alismatis, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Mume, the Cortex Eucommiae, Fructus Corni water decoct three times, 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate concentrates, and gets thick paste;
(3) with step (1) gained fine powder and (2) gained thick paste mixing, drying and crushing adds magnesium stearate, and mixing, tabletting are promptly.
Embodiment 3: Chinese medicinal composition capsules agent of the present invention
(1) get Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis and clean and be ground into fine powder, standby;
(2) Radix Trichosanthis, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Rehmanniae, Fructus Cucurbitae moschatae, Fructus Lycii, PORIA from Yunnan of China, Rhizoma Alismatis, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Mume, the Cortex Eucommiae, Fructus Corni water decoct three times, 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate concentrates, and gets thick paste;
(3) with step (1) gained fine powder and (2) gained thick paste mixing, drying and crushing adds starch, mixing, in the capsulae vacuus of packing into promptly.
Claims (5)
1, a kind of drug regimen that is used for the treatment of diabetes is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:
Radix Trichosanthis 2-20 part Rhizoma Anemarrhenae 2-10 part Rhizoma Dioscoreae 20-50 part
Radix Astragali 20-50 part 10-20 Radix Ophiopogonis part Fructus Schisandrae Chinensis 10-20 part
Radix Rehmanniae 10-30 part Fructus Cucurbitae moschatae 20-30 part Fructus Lycii 10-40 part
PORIA from Yunnan of China 10-30 part Radix Angelicae Sinensis 20-40 part Radix Salviae Miltiorrhizae 10-20 part
Rhizoma Alismatis 2-20 part Rhizoma Polygonati 5-15 part Rhizoma Polygonati Odorati 12-20 part
Fructus Mume 10-20 part Cortex Eucommiae 10-30 part Fructus Corni 10-20 part.
2, a kind of drug regimen that is used for the treatment of diabetes as claimed in claim 2 is characterized in that described effective ingredient made by weight by following raw materials according:
30 parts of 5 portions of Rhizoma Dioscoreaes of 10 parts of Rhizoma Anemarrhenaes of Radix Trichosanthis
15 parts of the Radix Astragali 15 parts of Fructus Schisandrae Chinensis, 30 parts of Radix Ophiopogonis
30 parts of 25 parts of Fructus Lycii of 15 portions of Fructus Cucurbitae moschataes of the Radix Rehmanniae
15 parts of 20 parts of Radix Salviae Miltiorrhizaes of 15 parts of Radix Angelicae Sinensis of PORIA from Yunnan of China
15 parts of 10 portions of Rhizoma Polygonati Odorati of 15 parts of Rhizoma Polygonatis of Rhizoma Alismatis
10 parts of 15 parts of Fructus Corni of 12 parts of Cortexs Eucommiae of Fructus Mume.
3, according to the described a kind of drug regimen that is used for the treatment of diabetes of claim 1-2, it is characterized in that adopting following method to make:
(1) get Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis earlier and clean and be ground into fine powder, standby;
(2) Radix Trichosanthis, the Rhizoma Anemarrhenae, Rhizoma Dioscoreae, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Rehmanniae, Fructus Cucurbitae moschatae, Fructus Lycii, PORIA from Yunnan of China, Rhizoma Alismatis, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Mume, the Cortex Eucommiae, Fructus Corni water decoct three times, 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate concentrates, and gets thick paste;
(3) with step (1) gained fine powder and (2) gained thick paste mixing, drying and crushing, and/or pharmaceutically acceptable carrier system granule, tablet, capsule.
4, according to any one described a kind of drug regimen that is used for the treatment of diabetes among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen that is used for the treatment of diabetes of claim 1-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810101423 CN101524471A (en) | 2008-03-06 | 2008-03-06 | Pharmaceutical composition for treating diabetes and preparation method thereof |
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| CN 200810101423 CN101524471A (en) | 2008-03-06 | 2008-03-06 | Pharmaceutical composition for treating diabetes and preparation method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578668A (en) * | 2012-03-05 | 2012-07-18 | 福建康之味食品工业有限公司 | Beverage for assisting in reducing blood sugar |
| CN104042909A (en) * | 2014-06-28 | 2014-09-17 | 张璟璟 | Medicine for treating diabetes |
| CN104758736A (en) * | 2015-04-13 | 2015-07-08 | 蒋来明 | Blood-glucose-reducing traditional Chinese medicine composition and preparation method thereof |
| CN104840736A (en) * | 2015-04-24 | 2015-08-19 | 吴中区胥口精益生物医药研究所 | Chinese medicinal blood sugar-lowering compound preparation and preparation method thereof |
| CN104840738A (en) * | 2015-05-18 | 2015-08-19 | 申洪恩 | Medicine for treating diabetes and production method thereof |
| CN105012666A (en) * | 2015-07-07 | 2015-11-04 | 杨红光 | Anion traditional Chinese medicine based medicament for treating diabetes |
| CN105395842A (en) * | 2015-11-09 | 2016-03-16 | 长葛市新世纪机电有限公司 | Traditional Chinese medicine composition for treating diabetes and oral preparation and preparation method thereof |
| CN105475884A (en) * | 2015-11-30 | 2016-04-13 | 山东鲁健生物医药科技有限公司 | Health food for patients with diabetes |
| CN108324852A (en) * | 2018-04-19 | 2018-07-27 | 合肥市风达农业有限责任公司 | A kind of Chinese medicine composition for treating diabetes |
| CN108578605A (en) * | 2018-07-18 | 2018-09-28 | 合肥华盖生物科技有限公司 | A kind of Chinese medicine composition for treating diabetes |
| CN108704115A (en) * | 2018-08-14 | 2018-10-26 | 山东省医药生物技术研究中心（山东省病毒研究所） | A kind of Chinese prescription and production method for treating diabetes B |
| CN111358895A (en) * | 2020-05-15 | 2020-07-03 | 广东省糖尿心脑血管医学研究院 | Chinese medicinal composition for treating diabetes, cardiovascular and cerebrovascular diseases, and its preparation method |
-
2008
- 2008-03-06 CN CN 200810101423 patent/CN101524471A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578668A (en) * | 2012-03-05 | 2012-07-18 | 福建康之味食品工业有限公司 | Beverage for assisting in reducing blood sugar |
| CN102578668B (en) * | 2012-03-05 | 2015-02-25 | 福建康之味食品工业有限公司 | Beverage for assisting in reducing blood sugar |
| CN104042909A (en) * | 2014-06-28 | 2014-09-17 | 张璟璟 | Medicine for treating diabetes |
| CN104758736A (en) * | 2015-04-13 | 2015-07-08 | 蒋来明 | Blood-glucose-reducing traditional Chinese medicine composition and preparation method thereof |
| CN104840736A (en) * | 2015-04-24 | 2015-08-19 | 吴中区胥口精益生物医药研究所 | Chinese medicinal blood sugar-lowering compound preparation and preparation method thereof |
| CN104840738A (en) * | 2015-05-18 | 2015-08-19 | 申洪恩 | Medicine for treating diabetes and production method thereof |
| CN105012666A (en) * | 2015-07-07 | 2015-11-04 | 杨红光 | Anion traditional Chinese medicine based medicament for treating diabetes |
| CN105395842A (en) * | 2015-11-09 | 2016-03-16 | 长葛市新世纪机电有限公司 | Traditional Chinese medicine composition for treating diabetes and oral preparation and preparation method thereof |
| CN105475884A (en) * | 2015-11-30 | 2016-04-13 | 山东鲁健生物医药科技有限公司 | Health food for patients with diabetes |
| CN108324852A (en) * | 2018-04-19 | 2018-07-27 | 合肥市风达农业有限责任公司 | A kind of Chinese medicine composition for treating diabetes |
| CN108578605A (en) * | 2018-07-18 | 2018-09-28 | 合肥华盖生物科技有限公司 | A kind of Chinese medicine composition for treating diabetes |
| CN108704115A (en) * | 2018-08-14 | 2018-10-26 | 山东省医药生物技术研究中心（山东省病毒研究所） | A kind of Chinese prescription and production method for treating diabetes B |
| CN111358895A (en) * | 2020-05-15 | 2020-07-03 | 广东省糖尿心脑血管医学研究院 | Chinese medicinal composition for treating diabetes, cardiovascular and cerebrovascular diseases, and its preparation method |
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Open date: 20090909 |