CN102114189A - Chinese medicinal blood glucose reducing tablet for treating diabetes comprising superfine powder - Google Patents
Chinese medicinal blood glucose reducing tablet for treating diabetes comprising superfine powder Download PDFInfo
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- CN102114189A CN102114189A CN2009102267923A CN200910226792A CN102114189A CN 102114189 A CN102114189 A CN 102114189A CN 2009102267923 A CN2009102267923 A CN 2009102267923A CN 200910226792 A CN200910226792 A CN 200910226792A CN 102114189 A CN102114189 A CN 102114189A
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Abstract
The invention relates to a Chinese medicinal blood glucose reducing tablet for treating diabetes.. The Chinese medicinal blood glucose reducing tablet comprises superfine powder and is prepared from fourleaf ladybell root, dwarf lilyturf tuber, Common anemarrhena, rehmannia root, noble dendrobium stem herb, gypsum, baikal skullcap root, Chinese goldthread rhizome, snakegourd root, Chinese magnoliavine fruit, milkvetch root, moutan bark, dan-shen root and licorice root. The tablet is prepared from the following steps: taking half of each of gypsum, baikal skullcap root, snakegourd root, milkvetch root, moutan bark and dan-shen root, adding Chinese goldthread rhizome, pulverizing into superfine powder with beili pulverizer, decocting the rest raw materials with water twice, mixing decoctions, filtering, concentrating filtrate to thick extract with relative density of 1.25-1.30 (60-70 DEG C), adding superfine powder, and processing into tablets. The tablet is administered for 3 times every day, with 3-4 tablets per time. The Chinese medicinal blood glucose reducing tablet has low cost and is easy for preparation and convenient for administration, the raw materials are easily accessible, and the effective ingredients can dissolve out and be digested, absorbed and utilized to a maximum extent. The tablet has the effects of nourishing yin, moistening dryness, turning recession trend of islet functions, and promoting revivification of islet cells. In addition, through administration of the tablets, patients need not to suffer from the bitter taste of traditional decoction.
Description
Technical field
The present invention relates to traditional Chinese medical science endo-medicine, especially treat the ultra micron Chinese medicine metformin of diabetes.
Background technology
Diabetes spp common clinical, frequently-occurring disease, mainly be to act on human body by various factors such as gene, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors to cause hypoinsulinism, islet function opposing and the disorderly syndromes of a series of metabolic functions such as the sugar that causes, protein, fat, power and water Xie Zhi.Be main feature clinically with the hyperglycemia.The visible polyuria of model case, polydipsia, polyphagia, performance such as become thin, i.e. " three-many-one-little " symptom.Diabetes are divided type i diabetes and type ii diabetes.Type i diabetes is mainly in teenager, and exogenous insulin is additional to earn a bare living because of the insulin secretion shortage relies on; Type ii diabetes is more common in middle-aged and elderly people, accounts for 95% of ratio, and clinical manifestation is that human body is responsive inadequately to insulin, i.e. islet function opposing.Doctor trained in Western medicine just gives the orally-taken blood sugar reducing medicine or makes insulinize the treatment of primary disease at present, is difficult to reach the effect that recovers islet function, and toxic and side effects is in various degree arranged, and treatment time is long, the expense costliness, and part patient is difficult to accept.The traditional Chinese medical science thinks that the etiology and pathogenesis of primary disease is mainly " the plain body deficiency of YIN, the five internal organs weakness, multiple because of eating and drinking without temperance, surfeit delicious food, disorder of emotion, excessive deficiency of kidney-YIN, the lung dryness of the stomach heat of causing of labor desire.Its pathogenesis emphasis is that the deficiency of YIN is scorching, is this with the deficiency of YIN, and is scorching for marking." basis " quench one's thirst lose to control, the consume of cloudy Tianjin, deficiency of YIN affecting YANG " pathology and " empty many real less, tonify deficiency is that main, removing the relative excess is auxilliary " distinguish and control principle." liver spleen kidney is with mending solely heavily the kidney invigorating in employing; Negative and positive are all mended, and lay particular stress on YIN nourishing " the treatment main points.Though the with a long history and irreplaceable advantage of TCM treatment of diabetes, traditional production and processing method, production technology, dosage form dosage disunity, the active ingredient of medicine is difficult to utilize fully, causes curative effect of medication to be limited to.
Summary of the invention
The purpose of this invention is to provide a kind of ultra micron Chinese medicine metformin for the treatment of diabetes.It adopts ultra micron grinding and processing new technique, and the active ingredient of medicine stripping farthest, digestion, absorption with the blood operation, reach nourishing YIN to relieve dryness, reverse islet function decline trend, promote the effect that the pancreas islet gland cell brings back to life.Avoided the hardship of traditional decoction Chinese medicine simultaneously.
The proportioning of technical solution of the present invention medicine side is: Radix Adenophorae 105 restrains, restrain Radix Ophiopogonis 105, the Rhizoma Anemarrhenae 70 restrains, the Radix Rehmanniae 70 restrains, Herba Dendrobii 70 restrains, Gypsum Fibrosum 70 restrains, Radix Scutellariae 70 restrains, Rhizoma Coptidis 14 restrains, Radix Trichosanthis 70 restrains, Fructus Schisandrae Chinensis 35 restrains, the Radix Astragali 70 restrains, Cortex Moutan 70 restrains, Radix Salviae Miltiorrhizae 70 restrains, Radix Glycyrrhizae 21 restrains.From said medicine, get Gypsum Fibrosum 35 grams, Radix Scutellariae 35 grams, Rhizoma Coptidis 14 grams, Radix Trichosanthis 35 grams, the Radix Astragali 35 grams, Cortex Moutan 35 grams, Radix Salviae Miltiorrhizae 35 grams, it is standby to be ground into ultra micron medicated powder, all the other medicines decoct with water, and add 8 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 2 hours.Twice medicinal liquid merged, filters, filtrate is condensed into the thick paste (60 ℃) of relative density 1.25-1.30, add above-mentioned ultra micron medicated powder again, dry, pulverize, add about 50 grams of supplementary product starch, mix homogeneously.With 85% ethanol system soft material, make granule (crossing 12 orders), 60-70 ℃ of cold drying, granulate is crossed the 20-60 mesh sieve, adds 0.3% magnesium stearate, tabletting behind the mix homogeneously.Wrap film-coat then, every heavy 0.35 gram is made 1000, an oral 3-4 grain, every day 3 times altogether.
The ultra micron Chinese medicine metformin that said medicine is formed, be according to motherland's Traditional Chinese medical theory and pathology of Diabetes Mellitus pathogenesis: " quench one's thirst lose to control, the consume of cloudy Tianjin, deficiency of YIN affecting YANG ", " void is many in fact less, tonify deficiency is the master, removing the relative excess is auxilliary; liver spleen kidney is with benefit, solely heavily the kidney invigorating; YIN nourishing is all mended, laid particular stress on to negative and positive " differential diagnosis of diseases is distinguished disease and scientific composition, Radix Adenophorae nourishing the lung to arrest cough, nourishing the stomach to promote the production of body fluid in the side; Lung moistening Radix Ophiopogonis clears away heart-fire, reinforcing stomach reg fluid; The Rhizoma Anemarrhenae, Herba Dendrobii is nourshing Yin and drynsessmoistening prescription, the tonifying YIN nourishing the stomach to promote the production of body fluid; The Radix Rehmanniae, Cortex Moutan clearing away heat and cooling blood, move back the stasis of blood of evapotranspiring; Gypsum Fibrosum, Rhizoma Coptidis, Radix Scutellariae clear away heart-fire lung gastric heat, eliminating fire and detoxication; The Radix Trichosanthis clearing away heat and promoting production of body fluid; The Fructus Schisandrae Chinensis arresting sweating quenches the thirst; Radix Astragali supplementing QI and nourishing YIN; The Radix Salviae Miltiorrhizae removing heat from blood clears away heart-fire, stasis-dispelling and pain-killing; Radix Glycyrrhizae heat-clearing and toxic substances removing, the mediation property of medicine, invigorating the spleen and replenishing QI.Play the detoxifcation of relieving inflammation or internal heat, heat clearing and blood cooling, promoting blood circulation to remove blood stasis, nourshing Yin and drynsessmoistening prescription, stomach reinforcing yin nourishing, invigorating the spleen and replenishing QI altogether, microcirculation improvement, tonify deficiency is set upright, improve diabetes patient's fasting glucose, post-prandial glycemia improves the C peptide, reverse islet function decline trend, promote curative effects such as pancreatic cell resurrection.
Adopt ultra micron Chinese medicine metformin treatment diabetes of the present invention, have abundant raw material, easy, with low cost, the taking convenience of preparation, have no side effect, the active ingredient stripping farthest of medicine, digest, absorb, move with blood, reach nourishing YIN to relieve dryness, reverse islet function decline trend, improve diabetics fasting glucose, post-prandial glycemia, raising C peptide, promote the effect that the pancreas islet gland cell brings back to life.Clinical treatment diabetics 121 examples, total effective rate reaches 83.4%, and that has avoided decoction Chinese medicine simultaneously waits bitterly for advantage and effect.
The specific embodiment
Embodiment is described in detail in detail below
Get Radix Adenophorae 105, Radix Ophiopogonis 105 grams, the Rhizoma Anemarrhenae 70 grams, the Radix Rehmanniae 70 grams, Herba Dendrobii 70 grams, Gypsum Fibrosum 70 grams, Radix Scutellariae 70 grams, Rhizoma Coptidis 14 grams, Radix Trichosanthis 70 grams, Fructus Schisandrae Chinensis 35 grams, the Radix Astragali 70 grams, Cortex Moutan 70 grams, Radix Salviae Miltiorrhizae 70 grams, Radix Glycyrrhizae 21 grams.Get Gypsum Fibrosum 35 grams, Radix Scutellariae 35 grams, Rhizoma Coptidis 14 grams, Radix Trichosanthis 35 grams, the Radix Astragali 35 grams, Cortex Moutan 35 grams, Radix Salviae Miltiorrhizae 35 grams from said medicine, it is standby to be ground into ultra micron medicated powder with the Baily pulverizer; All the other medicines decoct with water, and add 8 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 2 hours, and twice medicinal liquid merged, and filter, and filtrate is condensed into (60 ℃) thick paste of relative density 1.25-1.30.Add above-mentioned ultra micron medicated powder, dry, pulverizing, and add supplementary product starch, about 50g mix homogeneously.With 85% ethanol system soft material, cross 12 mesh sieves and make granule.60-70 ℃ of cold drying, granulate (cross 20-60 order) adds 0.3 magnesium stearate, and behind the mix homogeneously, tabletting, bag film-coat, every heavy 0.35 gram is made 1000, an oral 3-4 grain, every day 3 times altogether.
Clinical practice divides treatment group and matched group, and 121 people are organized in treatment, and wherein male 75 people, women 46 people are associated with hyperpietic 17 people, retinopathy person 8 people.Oral ultra micron Chinese medicine metformin is organized in treatment, and once oral 3-4 sheet, serve on three months at every day 3 times.Matched group 120 people, wherein male 69 people, women 51 people are associated with hyperpietic 15 people, retinopathy person 7 people.Matched group oral western medicine glibenclamide sheet 2.5mg treatment, 30 minutes before the meal morning, noon and afternoon every day are oral, and serve on three months, therapeutic outcome: 121 philtrums are organized in treatment, produce effects 30 people, effective 71 people, invalid 20 people, total effective rate 83.47%; Matched group 120 philtrums, produce effects 31 people, effective 59 people, invalid 30 people, total effective rate 75%.
Fasting glucose (FBS) before and after two groups of treatments, 2 hours after the meal blood glucose (PBS), glycolated hemoglobin (HbAlC), serum C peptide improvement situation (x ± s) relatively on an empty stomach
Claims (1)
1. ultra micron Chinese medicine metformin for the treatment of diabetes, it is characterized in that: the composition proportioning of this medicine side is: Radix Adenophorae 105 grams, Radix Ophiopogonis 105 gram, the Rhizoma Anemarrhenae 70 grams, the Radix Rehmanniae 70 grams, Herba Dendrobii 70 grams, Gypsum Fibrosum 70 grams, Radix Scutellariae 70 grams, Rhizoma Coptidis 14 grams, Radix Trichosanthis 70 grams, Fructus Schisandrae Chinensis 35 grams, the Radix Astragali 70 grams, Cortex Moutan 70 grams, Radix Salviae Miltiorrhizae 70 grams, Radix Glycyrrhizae 21 grams.From said medicine, get Gypsum Fibrosum 35 grams, Radix Scutellariae 35 grams, Rhizoma Coptidis 14 grams, Radix Trichosanthis 35 grams, the Radix Astragali 35 grams, Cortex Moutan 35 grams, Radix Salviae Miltiorrhizae 35 grams, be ground into ultra micron medicated powder with the Baily pulverizer, all the other medicines decoct with water, add for the first time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings for the second time and decocted 2 hours.Twice medicinal liquid merging, filtration, filtrate are condensed into the thick paste that relative density is 1.25-1.30, add above-mentioned ultra micron medicated powder again, after the drying, pulverize and add appropriate amount of auxiliary materials starch mix homogeneously.Low temperature 60-70 ℃ drying, granulate is crossed the 20-60 mesh sieve, adds 0.3% magnesium stearate, tabletting behind the mix homogeneously.Wrap film-coat then, every heavy 0.35 gram is made 1000, an oral 3-4 grain, every day 3 times altogether.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716342A (en) * | 2012-06-30 | 2012-10-10 | 高秀香 | Medicine for treating diabetes |
| CN103142842A (en) * | 2013-04-07 | 2013-06-12 | 龚定军 | Traditional Chinese medicine for treating diabetes mellitus |
| CN113908235A (en) * | 2021-12-02 | 2022-01-11 | 江苏省中医院 | Traditional Chinese medicine compound preparation for treating diabetic retinopathy and preparation method and application thereof |
| US20220041842A1 (en) * | 2021-06-22 | 2022-02-10 | China Yunhong Holdings Co., Ltd. | Method for preparing low-cost fully-biodegradable plant fiber starch tableware |
-
2009
- 2009-12-31 CN CN2009102267923A patent/CN102114189A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716342A (en) * | 2012-06-30 | 2012-10-10 | 高秀香 | Medicine for treating diabetes |
| CN102716342B (en) * | 2012-06-30 | 2014-07-09 | 高秀香 | Medicine for treating diabetes |
| CN103142842A (en) * | 2013-04-07 | 2013-06-12 | 龚定军 | Traditional Chinese medicine for treating diabetes mellitus |
| CN103142842B (en) * | 2013-04-07 | 2014-06-18 | 龚定军 | Traditional Chinese medicine for treating diabetes mellitus |
| US20220041842A1 (en) * | 2021-06-22 | 2022-02-10 | China Yunhong Holdings Co., Ltd. | Method for preparing low-cost fully-biodegradable plant fiber starch tableware |
| US11820882B2 (en) * | 2021-06-22 | 2023-11-21 | China Yunhong Holdings Co., Ltd. | Method for preparing low-cost fully-biodegradable plant fiber starch tableware |
| CN113908235A (en) * | 2021-12-02 | 2022-01-11 | 江苏省中医院 | Traditional Chinese medicine compound preparation for treating diabetic retinopathy and preparation method and application thereof |
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Application publication date: 20110706 |