CN101549045B - Traditional Chinese medicine preparation for treating diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating diabetes and a preparation method thereof. The traditional Chinese medicine preparation comprises the following main rawmaterials by weight parts: 6-140 parts of radix aconiti, 2-80 parts of leech, 8-180 parts of radix rehmanniae, 8-180 parts of euonymus alatus, 8-180 parts cortex lycii radicis, 3-100 parts of coptisroot, and 8-180 parts of lychee seed. The preparation method comprises the steps of 1, cleaning the medicinal materials including the radix aconiti which is the processed radix aconiti, the nux vomicawhich is the processed nux vomica, the short-pedicel aconite root which is prepared by liquorice, and the leech which is the processed leech, which are processed by detoxification, drying together with other medicinal materials and crushing, decocting for two times, merging the filtrate to obtain extract, condensing to obtain thick paste, and crushing to obtain medicinal powder; 2, processing senso with wine, and crushing to form fine powder; 3, adequately mixing the fine powder of the step 1 with the powder of the step 2 uniformly to obtain the medicinal powder, or adding auxiliary materials, and making into capsules or tablets. The invention has obvious curative effect, short treatment period and low relapse rate for diabetes and achieves the purpose of treating a disease by looking into both its root cause and symptoms.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, specifically refer to a kind of treatment diabetes Chinese medicine preparation and preparation method thereof.
Background technology:
Diabetes are that polygenic inheritance and environmental factors cause defect of insulin secretion or carbohydrate metabolism defective, cause the incretion metabolism disease of multisystem, MOFE at last.Diabetes are very big to human health risk, and the complication that diabetes caused is only second to tumor, cardiovascular diseases to the mankind's harm, become the killer No. three.Blood glucose when immunologic hypofunction or metabolism disorder, just very easily takes place and increases in factor affecting such as in the modern life, people's stress is big, physical training is few, eating and drinking too much at one meal, obesity, subhealth state, heredity, causes the generation of diabetes.According to statistics, diabetes number 2.46 hundred million people are suffered from the whole world, and China is up to 5,000 ten thousand people, at present, China's treating diabetes, expense costliness not only, and rely on Drug therapy throughout one's life, be difficult to cure.
Also use in the market some the treatment diabetes Chinese medicine, but most of curative effect not obvious, cure the symptoms, not the disease, the relapse rate height.
Summary of the invention:
The object of the present invention is to provide a kind of, treatment cycle short and relapse rate low Chinese medicine preparation obvious to the treating diabetes effect.Another object of the present invention is to provide a kind of preparation method for the treatment of the diabetes Chinese medicine preparation.
The object of the present invention is achieved like this, and its primary raw material medicine and weight proportion are as follows:
6～140 parts of Radix Aconitis, 2～80 parts of Hirudos, 8～180 parts in the Radix Rehmanniae, 8～180 parts of Ramulus Euonymis, 8～180 parts of Cortex Lycii, 3～100 parts of Rhizoma Coptidis, 8～180 parts of Semen Litchis.
Optimum weight proportioning of the present invention is as follows:
70 parts of Radix Aconitis, 30 parts of Hirudos, 100 parts in the Radix Rehmanniae, 100 parts of Ramulus Euonymis, 100 parts of Cortex Lycii, 100 parts of Rhizoma Coptidis, 100 parts of Semen Litchis.
The present invention also comprises one of following crude drug or its combination:
8～180 parts of Radix Ophiopogonis, 6～140 parts of the Rhizoma Atractylodis Macrocephalaes, 3～100 parts of the Radix Paeoniae Albas, 6～140 parts of Radix Ginsengs, 4～120 parts of the Rhizoma Anemarrhenaes, 4～120 parts of Spica Prunellaes, 0.1～20 part of Venenum Bufonis, 2～80 parts of Semen Strychni, 2～60 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 4～120 parts of Fructus Corni, 4～120 parts of Rhizoma amorphophallis, 8～180 parts of Stigma Maydis, 3～100 parts in Radix Glycyrrhizae.
Radix Aconiti in the side, Radix Ophiopogonis, Hirudo, the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are the monarch drug group.The Radix Aconiti expelling wind and removing dampness, dispersing cold for relieving pain has blood circulation promoting and blood stasis dispelling, antiinflammatory hypoglycemic activity.The Radix Aconiti polysaccharide, the energy enhancing body is to the utilization of sugar, and available Radix Aconiti Lateralis Preparata replaces, and consumption is identical.Radix Ophiopogonis, YIN nourishing was quenched one's thirst, and reinforcing stomach reg fluid has the raising immunity function.Radix Ophiopogonis polysaccharide, significantly blood sugar lowering impels the beta Cell of islet restore funcitons.The Hirudo removing blood stasis has the hemocoagulase of inhibition and improves the whole blood viscosity effect, can improve hypothalamus～hypophysis～target gland s function disorder, prevent and treat nephropathy and alleviate diabetic complication.The diuresis of Radix Rehmanniae heart tonifying, lowering blood sugar and preventing thirst has the raise immunity effect.Dihuang polysaccharide has obvious hypoglycemic activity, increases hepatic glycogen content.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, the dampness diuretic has blood sugar lowering, recovers damaged islet cells, suppresses the atrophy of pancreas effect.The Radix Paeoniae Alba is nourished blood and seeks, and holds back the rising tone liver, and the effect of antiinflammatory resisting pathogenic microbes is arranged.Crow Chinese herbaceous peony compatibility can reduce Radix Aconiti toxicity, strengthens the Radix Aconiti antiinflammatory action.Above-mentioned Six-element medicine is the monarch drug group, and YIN nourishing is astringent or styptic treatment for spontaneous sweating, activating blood circulation to dissipate blood stasis, and Tong Jing Xiao wei recovers damaged islet cells, thereby reaches the blood sugar lowering purpose.
With Ramulus Euonymi, Cortex Lycii, Radix Ginseng, the Rhizoma Anemarrhenae, Spica Prunellae is the ministerial drug group.The Ramulus Euonymi removing blood stasis stimulates the menstrual flow, and removing toxic substances and promoting subsidence of swelling has blood lipid regulation and blood sugar lowering effect; can reduce high density lipoprotein and total plasma cholesterol, increase the Lecithin-cholesterol acyltransferase. vigor, and can cause islet cells propagation; regulate abnormal metabolic process, increase insulin secretion.Cortex Lycii, clearind deficient heat, purte the white has analgesic and hypoglycemic activity, and glucose hyperglycemia and epinephrine hyperglycemia are had obvious blood sugar reducing function.The Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid and inducing sedation of the mind has the immunologic function of raising, strengthens carbohydrate metabolism.Rhizoma Anemarrhenae heat-clearing and toxic substances removing, nourshing Yin and drynsessmoistening prescription, antiinflammatory, resisting pathogenic microbes effect are arranged, various bacteria such as staphylococcus, escherichia coli etc. there are stronger inhibitory action, and the blood sugar lowering effect is arranged.The Spica Prunellae liver heat removing and eyesight improving, powder detoxifcation has antiinflammatory and hypoglycemic activity.Above five kinds of Chinese medicine is the ministerial drug group, heat-clearing and toxic substances removing, and strongly invigorating primordial QI, nourshing Yin and drynsessmoistening prescription, the enhancing body function carbohydrate metabolism.
Assistant is with Rhizoma Coptidis, Venenum Bufonis, Semen Strychni, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Fructus Corni.The Rhizoma Coptidis clearing away heat-fire, the dampness detoxifcation has antiinflammatory, anti-microbial effect, can suppress gluconeogenesis and promote glycolysis.The Venenum Bufonis reducing swelling and alleviating pain, detoxifcation is warded off dirty, and the raising immunity function is arranged.The Semen Strychni removing obstruction in the collateral to relieve pain, powder detoxifcation has antiinflammatory action.The Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) activating blood circulation to dissipate blood stasis has the obvious anti-inflammatory and anti effect.The Fructus Corni liver-kidney tonifying, convergence is taken off admittedly, antiinflammatory is arranged and improve immunity function.The cornusol extract has obvious blood sugar lowering effect to adrenal gland's diabetes.Above five kinds of Chinese medicine is the adjuvant drug group, clearing away heat-fire, and detoxifcation is warded off dirty, and liver-kidney tonifying improves immunity.
With Semen Litchi, Rhizoma amorphophalli, Stigma Maydis, Radix Glycyrrhizae is the messenger drug group.Kidney is good in the Semen Litchi spleen invigorating, and regulating QI to relieve pain has blood sugar lowering, effect for reducing blood fat.Rhizoma amorphophalli can improve blood constituent, and obvious hypoglycemic activity is arranged.The Stigma Maydis inducing diuresis to remove edema, the liver heat removing function of gallbladder promoting.The Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.More than four flavors for the messenger drug group, regulating qi-flowing for strengthening spleen, the liver heat removing function of gallbladder promoting has and has slow, improves curative effect.
Press the Chinese medical discrimination theory, the main etiology and pathogenesis of diabetes is retention of damp-heat in the interior, invades in the epidemic disease poison, the hear rate stagnation of QI, QI and blood is not all right, a little less than the dry spleen of liver, suffer from a deficiency of the kidney unbalance due to, the purpose that treatment should be astringent or styptic treatment for spontaneous sweating with heat-clearing and toxic substances removing, YIN nourishing, activating blood circulation to dissipate blood stasis, liver heat removing spleen invigorating, immunomodulating reach treating both the principal and the secondary aspects of a disease at the same time.Monarch of the present invention is respectively executed its effect, has tangible adjusting liver,spleen,kidney function, strengthens insulin secretion, improves the liver function effect.And can impel and increase the anti-sugar amount of cell, strengthen the regulatory function of nervous system to metabolic system, suppress virus and inflammation, thereby blood sugar lowering, glucose in urine reduces the generation of complication, curative effect is obvious, treatment cycle is short and relapse rate is low, reaches the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time.
The preparation method of the Chinese medicine preparation of above-mentioned treatment diabetes may further comprise the steps: 1, earlier medical material is washed, wherein Radix Aconiti is a Radix Aconiti Preparata, steaming method with hot pressing handles, Semen Strychni is a Semen Strychni (processed), stir-baking in sand method detoxification is handled, and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is a Radix Glycyrrhizae system, and Hirudo is a Hirudo (processed), scalding the drum detoxification with Pulvis Talci handles, with medical material natural drying or oven dry beyond the Venenum Bufonis, pulverizing is 100～200 order medicated powder, all medicine mix homogeneously then, put into extractor, soaked 3 hours, and decocted 2.5 hours～3 hours for the first time, leach, decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get activity extract, stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, dries, is ground into 100～200 order fine powders; 2, with behind the Venenum Bufonis processed with wine, pulverizing is 100～200 order fine powders; 3, with step 1, the abundant mix homogeneously of 2 fine powders, get medicated powder, or mixed uniformly medicated powder is added appropriate amount of auxiliary materials, make capsule, tablet or granule with common process.Adjuvant is meant filler, lubricant.Filler comprises one or more in solvable or microsolubility calcium salt, mannitol, starch, dextrin, the microcrystalline Cellulose; Lubricant comprises one or more in micropowder silica gel, Pulvis Talci, the magnesium stearate.
The present invention observes through 190 examples through clinical practice for many years, and this 190 routine case is divided into 2 groups at random, and wherein 110 examples are treated with the capsule of treatment diabetes of the present invention, and 80 is routine with the treatment of glipizide western drug.Reach blood glucose of beginning per 1～2 weekly check in back, glucose in urine before the treatment to observe its variation, require the patient must adhere to taking medicine one more than the course of treatment, three months is a course of treatment, continue to keep diet and physical exertion constant during the treatment, forbid adding other hypoglycemic in, western drug, viewing duration requires suitably to keep on a diet, and takes this prescription continuously after two courses of treatment, and total effective rate reaches 97.2%.
Treatment diabetes capsule group of the present invention (110 people), each oral 2～4, every day 3 times, 3 months is a course of treatment, drug withdrawal is obeyed the next course of treatment after 3 days again.
Glipizide treatment group (80 people): each oral 5mg, every day 3 times.
2 group of 190 routine case treated Comparison of therapeutic such as following table:
| Nomenclature of drug | Produce effects | Effectively | Invalid | Effective percentage % | Inefficiency % |
| The present invention treats the diabetes capsule | 49 | ?58 | ?3 | 97.2 | ?2.3 |
| The glipizide tablet | 25 | ?41 | ?14 | 82.5 | ?17.5 |
The main pharmacodynamics result:
1, diabetes Chinese medicine preparation of the present invention is to the influence of alloxan diabetes mice hyperglycemia.
Chinese medicine preparation of the present invention is to the influence of alloxan diabetes mice hyperglycemia
Annotate: (1), number of animals: 50 of Kunming kind white mice, body weight 18-22g, male and female half and half are divided into 5 groups immediately, 10 of normal control groups, 10 of model group, 10 of heavy dose of groups, 10 of small dose group, 10 of glipizide tablet groups.
(2), compare * P＜0.05, * * P＜0.01 with model control group
As can be seen from the table, the mouse mainline alloxan is after 72 hours, and the model group blood sugar concentration is significantly higher than the normal control group.After continuous 10 days, mouse blood sugar concentration is starkly lower than model group with diabetes Chinese medicine preparation 1.14g/kg.0.57g/kg dosage also can reduce blood glucose in diabetic mice, illustrates that these diabetes Chinese medicine preparation has the effect of blood sugar lowering.
2, animal acute toxicity test
Get 40 of Kunming kind white mice, be divided into 2 groups immediately: administration group and matched group, every group 20, male and female half and half, fasting (can't help water) is after 14 hours before the test, administration group mice is irritated stomach (ig) with the Chinese medicine preparation of Cmax 1.14g crude drug/ml and gives and maximum volume 0.8ml/20g, matched group is irritated the distilled water of stomach equal volume, and administration is 2 times in one day, and the accumulative total dosage is 91.2g crude drug/kg, observed after the administration 7 days, and observed animal behavior activity etc. and survival condition every day.Chinese medicine preparation group and distilled water matched group there is no mice Deviant Behavior, the hair color light, and convenient to both normal, body weight gain does not relatively have notable difference for two groups, does not also have animal dead.Behind execution and the dissection animal, the perusal heart, liver, spleen, lung, kidney etc. are all no abnormal, show that the Chinese medicine preparation maximum dosage-feeding can reach 91.2 crude drugs/kg, convert 2660 times that are equivalent to the clinical consumption of 70kg people by kg body weight, be equivalent to 295 times of the clinical consumption of 70kg people by the body surface area conversion.The results are shown in following table:
Diabetes Chinese medicine preparation The acute toxicity tests
Compare * P＞0.05 with matched group.
As can be seen from the table, give mouse stomach, all fail to obtain LD with the Chinese medicine preparation of Cmax, maximum volume
50, its maximum dosage-feeding can reach 91.2g crude drug/kg, is equivalent to be grown up 2660 times of clinical consumption of 70kg by kg body weight conversion, and mice does not see overt toxicity or unusual, shows that the disposable administration of this Chinese medicine preparation is safe.
The specific embodiment:
Embodiment 1: get 70 parts of Radix Aconitis, 30 parts of Hirudos, 100 parts in the Radix Rehmanniae, 100 parts of Ramulus Euonymis, 100 parts of Cortex Lycii, 100 parts of Rhizoma Coptidis, 100 parts of Semen Litchis.Earlier medical material is washed, wherein Hirudo is a Hirudo (processed), and Radix Aconiti is a Radix Aconiti Preparata, then all medical material natural drying or oven dry, pulverizing is 100～200 order medicated powder, and all medicine mix homogeneously are put into extractor, soaked 3 hours, and decocted 2.5 hours～3 hours for the first time, leach; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get activity extract.Stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, dries, is ground into 100～200 order fine powders.Make capsule with common process.Usage is every day 3 times, each 2～4, and every 500mg, ante cibum or one hour after meal take, and plain boiled water is taken after mixing it with water.
Embodiment 2: get 7 parts of Radix Aconitis, 10 parts of Radix Ophiopogonis, 3 parts of Hirudos, 6 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of the Radix Paeoniae Albas, 10 parts in the Radix Rehmanniae, 10 parts of Ramulus Euonymis, 10 parts of Cortex Lycii, 7 parts of Radix Ginsengs, 5 parts of the Rhizoma Anemarrhenaes, 5 parts of Spica Prunellaes, 4 parts of Rhizoma Coptidis, 5 parts of Fructus Corni, 10 parts of Semen Litchis, 5 parts of Rhizoma amorphophallis, 10 parts of Stigma Maydis, 3 parts in Radix Glycyrrhizae.Earlier medical material is washed, wherein Hirudo is a Hirudo (processed), and Radix Aconiti is a Radix Aconiti Preparata, then all medical material natural drying or oven dry, pulverizing is 100～200 order medicated powder, and all medicine mix homogeneously are put into extractor, soaked 3 hours, and decocted 2.5 hours～3 hours for the first time, leach; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get activity extract.Stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, dries, is ground into 100～200 order fine powders.Make capsule with common process.Usage is every day 3 times, each 2～4, and every 500mg, ante cibum or one hour after meal take, and plain boiled water is taken after mixing it with water.
Embodiment 3: get 140 parts of Radix Aconitis, 180 parts of Radix Ophiopogonis, 80 parts of Hirudos, 100 parts of the Radix Paeoniae Albas, 180 parts in the Radix Rehmanniae, 140 parts of the Rhizoma Atractylodis Macrocephalaes, 180 parts of Ramulus Euonymis, 180 parts of Cortex Lycii, 140 parts of Radix Ginsengs, 120 parts of the Rhizoma Anemarrhenaes, 120 parts of Spica Prunellaes, 100 parts of Rhizoma Coptidis, 20 parts of Venenum Bufoniss, 80 parts of Semen Strychni, 60 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 120 parts of Fructus Corni, 180 parts of Semen Litchis, 120 parts of Rhizoma amorphophallis, 180 parts of Stigma Maydis, 100 parts in Radix Glycyrrhizae.Produce according to the following steps: 1, earlier medical material is washed, wherein Radix Aconiti is a Radix Aconiti Preparata, and Semen Strychni is a Semen Strychni (processed), and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is a Radix Glycyrrhizae system, Hirudo is a Hirudo (processed), with medical material natural drying or oven dry beyond the Venenum Bufonis, pulverizing is 100～200 order medicated powder, all medicine mix homogeneously then, put into extractor, soaked 3 hours, and decocted 2.5 hours～3 hours for the first time, leach; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get activity extract.Stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, dries, is ground into 100～200 order fine powders.2, with behind the Venenum Bufonis processed with wine, pulverizing is 100～200 order fine powders.3, with step 1, the abundant mix homogeneously of 2 fine powders, make capsule with common process.Usage is every day 3 times, each 2～4, and every 500mg, ante cibum or one hour after meal take, and plain boiled water is taken after mixing it with water.
Concrete case:
1, the patient woman suffered from diabetes 6 years in 51 years old, thirsty, urine is many, and dizzy tinnitus symptom is often arranged, fasting glucose 8.96mmol/l, two hours after the meal blood glucose 18.24mmol/l begin to take Chinese medicine preparation capsule of the present invention in February, 2005, after two months, fasting glucose returns to 5.9mmol/l, two hours after the meal blood glucose 8.1mmol/l keep stable so far, no longer obey any medicine.
2, patient man readme in 54 years old was suffered from diabetes 8 years, thirsty polydipsia, and fatigue and weak, the frequent micturition frequent micturition, health is become thin, fasting glucose 16.3mmol/l.Take Chinese medicine preparation capsule of the present invention after 3 months, fasting glucose remains on about 6.0mmol/l, and urine is normal, and physical recovery health is no longer obeyed any medicine.
Claims (5)
1. treat the diabetes Chinese medicine preparation for one kind, it is characterized in that: its crude drug and weight proportion are as follows: 70 parts of Radix Aconitis, 30 parts of Hirudos, 100 parts in the Radix Rehmanniae, 100 parts of Ramulus Euonymis, 100 parts of Cortex Lycii, 100 parts of Rhizoma Coptidis, 100 parts of Semen Litchis.
2. treat the diabetes Chinese medicine preparation for one kind, it is characterized in that: its crude drug and weight ratio are as follows: 7 parts of Radix Aconitis, 10 parts of Radix Ophiopogonis, 3 parts of Hirudos, 6 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of the Radix Paeoniae Albas, 10 parts in the Radix Rehmanniae, 10 parts of Ramulus Euonymis, 10 parts of Cortex Lycii, 7 parts of Radix Ginsengs, 5 parts of the Rhizoma Anemarrhenaes, 5 parts of Spica Prunellaes, 4 parts of Rhizoma Coptidis, 5 parts of Fructus Corni, 10 parts of Semen Litchis, 5 parts of Rhizoma amorphophallis, 10 parts of Stigma Maydis, 3 parts in Radix Glycyrrhizae.
3. treat the diabetes Chinese medicine preparation for one kind, it is characterized in that: its crude drug and weight ratio are as follows: 140 parts of Radix Aconitis, 180 parts of Radix Ophiopogonis, 80 parts of Hirudos, 100 parts of the Radix Paeoniae Albas, 180 parts in the Radix Rehmanniae, 140 parts of the Rhizoma Atractylodis Macrocephalaes, 180 parts of Ramulus Euonymis, 180 parts of Cortex Lycii, 140 parts of Radix Ginsengs, 120 parts of the Rhizoma Anemarrhenaes, 120 parts of Spica Prunellaes, 100 parts of Rhizoma Coptidis, 20 parts of Venenum Bufoniss, 80 parts of Semen Strychni, 60 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 120 parts of Fructus Corni, 180 parts of Semen Litchis, 120 parts of Rhizoma amorphophallis, 180 parts of Stigma Maydis, 100 parts in Radix Glycyrrhizae.
4. according to claim 1,2 or 3 described treatment diabetes Chinese medicine preparation, it is characterized in that: it is capsule, tablet, granule, drop pill or powder.
5. preparation method as treatment diabetes Chinese medicine preparation as described in the claim 3, it is characterized in that: comprise the steps: 1, earlier medical material is washed, wherein Radix Aconiti is a Radix Aconiti Preparata, steams method with hot pressing and handles, and Semen Strychni is a Semen Strychni (processed), stir-baking in sand method detoxification is handled, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is a Radix Glycyrrhizae system, and Hirudo is a Hirudo (processed), scalds the drum detoxification with Pulvis Talci and handles, then with medical material natural drying or oven dry beyond the Venenum Bufonis, pulverizing is 100～200 order medicated powder, and all medicine mix homogeneously are put into extractor, soaked 3 hours, decocted 2.5 hours～3 hours for the first time, leach, decocted 1.5 hours～2 hours for the second time, leach, twice filtrate is merged, get activity extract, stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, oven dry, be ground into 100～200 order fine powders; 2, with behind the Venenum Bufonis processed with wine, pulverizing is 100～200 order fine powders; 3,, get medicated powder with step 1, the abundant mix homogeneously of 2 fine powders; Or, make capsule, tablet or granule with common process with mixed uniformly medicated powder adding appropriate amount of auxiliary materials.
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| CN105770428A (en) * | 2016-04-25 | 2016-07-20 | 王维娜 | Traditional Chinese medicine preparation for treating diabetes and preparation method for traditional Chinese medicine preparation |
| CN105998628A (en) * | 2016-07-13 | 2016-10-12 | 黄禄成 | Traditional Chinese medicine preparation for treating diabetes as well as preparation method and application of traditional Chinese medicine preparation |
| CN107375665A (en) * | 2017-06-10 | 2017-11-24 | 朱友文 | A kind of Chinese medicine preparation for treating diabetes and preparation method thereof |
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| CN1235551A (en) * | 1996-11-01 | 1999-11-17 | 参天堂制药株式会社 | Pharmaceutical composition for diabetes |
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| CN1235551A (en) * | 1996-11-01 | 1999-11-17 | 参天堂制药株式会社 | Pharmaceutical composition for diabetes |
Non-Patent Citations (1)
| Title |
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| 李志豪 .糖尿病的中药疗法研究进展.《杭州师范学院学报(医学版)》.2007,第27卷(第1期),58-60. * |
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