CN105125851A - Traditional Chinese medicine treating 2-type diabetes and preparation technology - Google Patents
Traditional Chinese medicine treating 2-type diabetes and preparation technology Download PDFInfo
- Publication number
- CN105125851A CN105125851A CN201510704306.XA CN201510704306A CN105125851A CN 105125851 A CN105125851 A CN 105125851A CN 201510704306 A CN201510704306 A CN 201510704306A CN 105125851 A CN105125851 A CN 105125851A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- fructus
- poria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides traditional Chinese medicine treating 2-type diabetes and a preparation technology. The traditional Chinese medicine treating 2-type diabetes is prepared from, by weight, 20-50 parts of Chinese rhubarb, 60-90 parts of radix rehmanniae, 80-120 parts of pachyrhizua angulatus, 100-150 parts of astragalus, 50-80 parts of radix ophiopogonis, 80-120 parts of Chinese yam, 10-30 parts of liquorice, 60-90 parts of scrophulariae, 15-35 parts of cassia twigs and 85-115 parts of peach seeds.
Description
Technical field
The invention belongs to the method field of Chinese traditional treatment type 2 diabetes mellitus and chronic complicating diseases thereof, relate to a kind of Chinese patent medicine medicine for the treatment of diabetes and complication thereof.
Background technology
The metabolic disease that type 2 diabetes mellitus is is feature with blood glucose rising, persistent high blood sugar and long-term metabolic are disorderly etc. can cause body tissue's organ, causes chronic complicating diseases, lethal, disability rate is high, serious threat human health.The determined curative effect of TCM Treatment of Diabetes and chronic complicating diseases thereof.
Summary of the invention
For the problems referred to above, the invention provides a kind of rational in infrastructure, reduce and cause this, the Chinese medicine for the treatment of type 2 diabetes mellitus that can be luminous.
To achieve the above object of the invention, the present invention treats the Chinese medicine of type 2 diabetes mellitus, comprises the component of following weight portion:
Radix Et Rhizoma Rhei 20 ~ 50 parts, Radix Rehmanniae 60 ~ 90 parts, Pachyrhizua angulatus 80 ~ 120 parts, the Radix Astragali 100 ~ 150 parts, Radix Ophiopogonis 50 ~ 80 parts, Rhizoma Dioscoreae 80 ~ 120 parts, 10 ~ 30 parts, Radix Glycyrrhizae, Radix Scrophulariae 60 ~ 90 parts, Ramulus Cinnamomi 15 ~ 35 parts, 85 ~ 115 parts, Semen Persicae.
Detailed description of the invention
The present invention will be further described below.
The medicine composition of the treatment Chinese Patent Drugs for Diabetes " blood sugar lowering SANHUANG PIAN " related under the inventive method is made up of prescription Jiawei-Taohong-Siwu S oup (certainly the side of plan), concrete medicine comprises: Radix Et Rhizoma Rhei 20 ~ 50 parts, Radix Rehmanniae 60 ~ 90 parts, Pachyrhizua angulatus 80 ~ 120 parts, the Radix Astragali 100 ~ 150 parts, Radix Ophiopogonis 50 ~ 80 parts, Rhizoma Dioscoreae 80 ~ 120 parts, 10 ~ 30 parts, Radix Glycyrrhizae, Radix Scrophulariae 60 ~ 90 parts, Ramulus Cinnamomi 15 ~ 35 parts, Semen Persicae 85 ~ 115g.
The concrete method for making of said medicine formula: above ten tastes, gets Rhizoma Dioscoreae, is ground into fine powder; Nine tastes such as all the other Radix Et Rhizoma Rhei decoct with water secondary, 1.5 hours first times, second time 1 hour, merge secondary decocting liquid, filter, filtrate is concentrated into thick paste, add above-mentioned Rhizoma Dioscoreae fine powder, mixing, dry, pulverize, add dextrin 45 ~ 60g, mixing, make granule, dry, add appropriate amount of auxiliary materials: 0.5 ~ 1% magnesium stearate, 2 ~ 3% Pulvis Talci, are pressed into 1000, obtain final product.Medicine character: this product is brown to brown color chips; Bitter in the mouth.Pharmic function cures mainly: nourshing Yin and drynsessmoistening prescription, supplementing QI for promoting the production of body fluid, blood circulation promoting and blood stasis dispelling, for adult's diabetics.Usage and dosage: oral, one time 8 ~ 10,3 times on the one, half an hour ante cibum takes.User physical examination: the every regulation under Chinese Pharmacopoeia part tablet item should be met.Pharmaceutical specifications: 0.25g/ sheet, 100 slices/bottle.Drug storage method: sealing, protection against the tide.Effect duration: 24 months.Drug use points for attention: anemia of pregnant woman is cautious use of.
Experiment case study 1
Patient, man, 52 years old, first visit on February 26 in 2013.Patient is the rising of health check-up discovery blood glucose before 6 days, glycolated hemoglobin 11%, fasting glucose 11.47mmol/L.Xerostomia polydipsia usually, easily hungry, become thin 8 jin over one year, receive dormancy can, two just adjust, red tongue, tongue in vain greasy, have indentation, thready pulse.GEGEN QINLIAN TANG, SHENGMAI SAN are closed with WEIDANTANG by side, focus on invigorating the spleen for dissipating phlegm, heat clearing and damp drying, YIN nourishing and the production of body fluid promoting of holding concurrently.Prescription: Poria 20g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri Reticulatae 10g, Rhizoma Pinelliae Preparatum 10g, Fructus Aurantii 10g, Caulis Bambusae In Taenia 10g, Rhizoma Coptidis 20g, Pachyrhizua angulatus 30g, Radix Scutellariae 10g, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 20g, Rhizoma Atractylodis 30g, Radix Polygoni Multiflori 30g, Fructus Crataegi 15g, Semen Cassiae 15g, Radix Rehmanniae 20g, Radix Ophiopogonis 30g.7 doses, every day 1 dose, decocting sub-service sooner or later.Separately give Chinese patent medicine: each 8 of blood sugar lowering SANHUANG PIAN, every day 3 times, each 0.3g of Berberine Tablet, every day 3 times, each 4 of warm bladder, every day 3 times, taking medicine after meal.And advise patient to improve Diabetes specialist inspection.Two examine (on March 2nd, 2013): look into fasting glucose 12.45mmol/L, after the meal 0.5h blood glucose 21.61mmol/L, after the meal 1h blood glucose 26.2mmol/L, 2h-plasma glucose 26.76mmol/L, after the meal 3h blood glucose 19.9mmol/L; Look into insulin releasing: 17.7 μ IU/ml, after the meal 0.5h11.96 μ IU/ml, after the meal 1h23.12 μ IU/ml, after the meal 2h19.19 μ IU/ml, after the meal 3h20.69 μ IU/ml on an empty stomach.After patient takes top, xerostomia polydipsia symptom takes a turn for the better.Quarter examines: slight dry mouth with bitter taste, and stomach is received good, easily hungry, and large dry stool, every day 1 time, the micro-Huang of urine, amount are few, dormancy can, tongue is dark red, white and thin fur, stringy pulse.Continue and give WEIDANTANG conjunction GEGEN QINLIAN TANG, SHENGMAI SAN, invigorating the spleen for dissipating phlegm, heat clearing and damp drying, YIN nourishing and the production of body fluid promoting of holding concurrently, and add Rhizoma Polygoni Cuspidati with purging FU-organs except stopping up, walk help gas eliminates the phlegm.Prescription: Poria 20g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri Reticulatae 10g, Rhizoma Pinelliae Preparatum 10g, Fructus Aurantii 10g, Caulis Bambusae In Taenia 10g, Rhizoma Coptidis 30g, Pachyrhizua angulatus 45g, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 20g, Rhizoma Atractylodis 30g, Radix Polygoni Multiflori 30g, Semen Cassiae 15g, Radix Rehmanniae 20g, Radix Ophiopogonis 30g, Rhizoma Polygoni Cuspidati 30g, Radix Trichosanthis 15g, Rhizoma Zingiberis 6g.Every day 1 dose, decocting sub-service sooner or later.Chinese patent medicine is same examines.Three examine (on March 16th, 2013): look into fasting glucose 7.6mmol/L.The transference cure such as dry mouth with bitter taste, easy famine behind clothes top.Quarter examines: blurred vision, facial hot feeling, remaining without uncomfortable.Red tongue, white and thin fur, stringy pulse.No more side effects, continues keep top and add Fructus Lycii, Flos Buddlejae, Semen Celosiae with nourishing the liver to improve visual acuity.Prescription: Poria 20g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri Reticulatae 6g, Rhizoma Coptidis 20g, Pachyrhizua angulatus 30g, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 20g, Rhizoma Atractylodis 30g, Radix Polygoni Multiflori 30g, Radix Rehmanniae 30g, Radix Ophiopogonis 30g, Rhizoma Polygoni Cuspidati 30g, Radix Trichosanthis 15g, Fructus Lycii 15g, Flos Buddlejae 15g, Semen Celosiae 15g.Every day 1 dose, decocting sub-service sooner or later.Chinese patent medicine is same examines.The four diagnostic methods (on April 20th, 2013): look into fasting glucose 7.1mmol/L.Quarter examines: facial hot feeling disappears, and still has blurred vision, large dry stool, every day 1 time, yellow urine, receive dormancy can, red tongue, yellow and thin fur, floating pulse string.No more side effects, continues three diagnosis and treatment and treats.Five examine (on May 25th, 2013): look into glycolated hemoglobin 7.0%.Quarter examines: patient without significant discomfort, receive dormancy can, yellow urine, large dry stool, every day 1 time, tongue is dark red, yellow and thin fur, stringy pulse.Square Herba Sidae Rhombifoliae soup, Herba Artemisiae Scopariae Decoction, GEGEN QINLIAN TANG conjunction side, with treating SHAO YANG disease by mediation, fluent three is burnt, eliminating damp-heat.Prescription: Radix Bupleuri 10g, Radix Scutellariae 10g, Rhizoma Pinelliae Preparatum 10g, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 30g, Fructus Jujubae 10g, Radix Glycyrrhizae Preparata 6g, Pachyrhizua angulatus 30g, Rhizoma Coptidis 10g, Herba Epimedii 15g, Fructus Amomi 6g, Radix Paeoniae Alba 15g, Rhizoma Polygoni Cuspidati 30g, Radix Trichosanthis 15g, Stigma Maydis 30g, Herba Artemisiae Scopariae 20g, Radix Salviae Miltiorrhizae 10.Every day 1 dose, decocting sub-service sooner or later.Chinese patent medicine is same examines.Six examine (on June 29th, 2013): look into fasting glucose 6.3mmol/L.Behind clothes top, large dry stool disappears, and yellow urine disappears.Quarter examines: receive dormancy can, without to be obviously afraid of cold, To Be Protected from Heat, without dry mouth with bitter taste, light red tongue, white and thin fur Huang, thready pulse.No more side effects, continues five diagnosis and treatment and treats.Seven examine (on July 30th, 2013): look into fasting glucose 5.67mmol/L.Conscious of significant discomfort behind clothes top.Quarter examines: blurred vision, wears presbyopic glasses backsight thing clear, and without dizzy, uncomfortable in chest, numb limbs and tense tendons, two just adjust, sleep can, keep on a diet, light red tongue, white and thin fur, thready pulse.Square with Chai Shao Radix Rehmanniae Tonga taste, with nourishing the liver and kidney, nourishing the liver to improve visual acuity.Prescription: Radix Bupleuri 10g, Radix Paeoniae Alba 10g, Fructus Lycii 15g, Flos Chrysanthemi 10g, Radix Rehmanniae Preparata 20g, Rhizoma Dioscoreae 30g, Fructus Corni 15g, Cortex Moutan 10g, Poria 15g, Rhizoma Alismatis 10g, Flos Buddlejae 15g, Herba Senecionis Scandentis 15g, Fructus Leonuri 15g, Herba Epimedii 15g, Fructus Amomi 6g.Every day 1 dose, decocting sub-service sooner or later.Give each 8 of blood sugar lowering SANHUANG PIAN, every day 3 times, each 0.3g of Berberine Tablet, every day 3 times, each 8 of QIJU DIHUANG WAN, every day time, taking medicine after meal.Rear patient monthly timing further consultation, monthly 7 doses of Chinese medicines, took 1 dose every 3 days.Keep bavin Chinese herbaceous peony Dihuang Decoction nourishing the liver and kidney, check on November 16th, 2013 glycolated hemoglobin 5.9%.Follow up a case by regular visits to in October, 2014, patient blood glucose controlled in normal range always.Check a hepatic and renal function per March, all without exception.
Experiment case study 2
Patient, man, 34 years old, first visit on August 7 in 2012.Patient is weight loss over nearly 1 month, and occurs the symptoms such as xerostomia polydipsia, polyuria, looks into fasting glucose 15.95mmol/L, glycolated hemoglobin 11.3%.Quarter examines: dry mouth with bitter taste, and amount of drinking water is many, happiness drinking cold water, numbness of hands and feet, swelling sense, receive can, sleeps poor, Yi Xing, limbs fatigue, and yellow urine, often, abnormal smells from the patient is dense, large loose stool, every day 1 time, and red tongue has tooth print, tongue greasy in vain, stringy and rolling pulse.The product of heat clearing and damp drying close with Chaihu Guizhi Ganjiang Tang, SHENGMAI SAN in side, with few sun, temperature is lunar, heat clearing and damp drying of holding concurrently, enriching yin boost qi., prescription: Radix Bupleuri 10g, Ramulus Cinnamomi 10g, Rhizoma Zingiberis 10g, Concha Ostreae 30g, Radix Trichosanthis 15g, Fructus Jujubae 10g, Radix Glycyrrhizae Preparata 6g, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 30g, Herba Epimedii 15g, Fructus Amomi 6g, Rhizoma Atractylodis 30g, Rhizoma Coptidis 20g, Stigma Maydis 30g, Radix Rehmanniae 20g, Radix Ophiopogonis 30g, Fructus Schisandrae Chinensis 10g.7 doses, every day 1 dose, decocting sub-service sooner or later.Give each 8 of blood sugar lowering SANHUANG PIAN, every day 3 times, each 0.3g of Berberine Tablet, every day 3 times, taking medicine after meal.And enjoin patient to improve Diabetes specialist coherence check as early as possible.Two examine (on August 14th, 2012): look into fasting glucose 11mol/L.Bitter taste and limbs fatigue symptom are obviously improved.Quarter examines: To Be Protected from Heat, glutinous soapy feeling in xerostomia, mouth, and after hyperhidrosis, antiperspirant, skin sticks greasy, trick fiber crops, and neck does not relax, and difference of sleeping easily is waken up, and total urination time is many, yellow skin is highly seasoned, stool can, red tongue, tongue are greasy in vain, stringy and thready pulse.Side with GEGEN QINLIAN TANG, decoction of four noble drugs, SHENGMAI SAN add purging FU-organs and remove stagnant product, with heat clearing and damp drying, purging FU-organs except stopping up, enriching yin boost qi.Prescription: Poria 20g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri Reticulatae 10g, Rhizoma Coptidis 20g, Pachyrhizua angulatus 30g, Radix Scutellariae 10g, Radix Codonopsis 20g, Rhizoma Atractylodis 30g, Rhizoma Polygoni Cuspidati 20g, Fructus Crataegi 10g, Semen Cassiae 15g, Stigma Maydis 30g, Herba Epimedii 15g, Fructus Amomi 6g, Radix Rehmanniae 20g, Radix Ophiopogonis 20.Every day 1 dose, decocting sub-service sooner or later.Chinese patent medicine is same examines.Three examine (on August 25th, 2012), the four diagnostic methods (on JIUYUE 15th, 2012): stable disease.Quarter examines: receive dormancy can, large loose stool, frequently, light red tongue is dark, tongue is white, thready and rolling pulse for yellow urine, number of times.Cling conditions closes with GEGEN QINLIAN TANG in side, using medicines of both cold and hot natures simultaneously, clearing heat and expelling damp, warming middle-JIAO and strengthening the spleen.Prescription: Poria 20g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri Reticulatae 10g, Rhizoma Coptidis 20g, Pachyrhizua angulatus 30g, Radix Scutellariae 10g, Radix Codonopsis 30g, Rhizoma Atractylodis 30g, Semen Cassiae 15g, Stigma Maydis 30g, Herba Epimedii 15g, Fructus Amomi 6g, Radix Rehmanniae 20g, Radix Aconiti Lateralis Preparata 6g, Rhizoma Zingiberis 6g, the Radix Linderae 10.Every day 1 dose, decocting sub-service sooner or later.Chinese patent drugs for treatment is same examines.Five examine (on October 18th, 2012): period looks into fasting glucose 8 ~ 10mmol/L, 2h-plasma glucose 10mmol/L.The symptoms such as xerostomia are obviously alleviated, but still sense numb hand and foot, Mental fatigue, and lower limb are weak, the soreness of waist, stomach receive can, without dry mouth with bitter taste, difference of sleeping easily is waken up, and two just adjust, light red tongue secretly, yellow and thin fur, thready and stringy pulse.Square with Guizhi Jia Gegen Tang, Huangqi Guizhi Wuwu Tang, DANGGUI SHAOYAO SAN, Mahuang Fuzi Xixin Tang conjunction side, blood circulation promoting and blood stasis dispelling dredging collateral, simultaneously warming the kidney to activate YANG.Prescription: Ramulus Cinnamomi 10g, Radix Paeoniae Alba 10g, Fructus Jujubae 10g, Radix Glycyrrhizae Preparata 6g, Pachyrhizua angulatus 60g, Radix Angelicae Sinensis 15g, Rhizoma Alismatis 20g, Rhizoma Chuanxiong 10g, Poria 30g, Rhizoma Atractylodis Macrocephalae (parched) 20g, Radix Codonopsis 30g, Radix Astragali 30g, Herba Ephedrae 5g, Radix Aconiti Lateralis Preparata 6g, Herba Asari 3g, Rhizoma Zingiberis Recens 10g.Every day 1 dose, decocting sub-service sooner or later.Chinese patent drugs for treatment is same examines.Six examine (on November 8th, 2012): look into glycolated hemoglobin 9.6%.Patient still feels double-legged toes fiber crops, neurolysis, uneasy sleeping at night, and remaining disease alleviates, and diet two is just normal, and light red tongue has indentation, white and thin fur, stringy and thready pulse.Decoction of four noble drugs, GEGEN QINLIAN TANG are closed with Sini San by side, and add the product of calming the nerves, soothing liver and strengthening spleen, clearing heat and expelling damp, restoring normal coordination between the heart and kidney.Prescription: Radix Bupleuri 10g, Radix Paeoniae Alba 10g, Fructus Aurantii 10g, Radix Glycyrrhizae Preparata 6g, Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Pachyrhizua angulatus 15g, Radix Scutellariae 10g, Rhizoma Coptidis 20g, Semen Ziziphi Spinosae (parched) 20g, Caulis Polygoni Multiflori 30g, Spica Prunellae 15g, Rhizoma Pinelliae Preparatum 15g, Herba Epimedii 15g, Fructus Amomi 6g.Every day 1 dose, decocting sub-service sooner or later.Chinese patent drugs for treatment is same examines.Again enjoin patient to improve diabetes to be as early as possible correlated with training inspection.Seven examine (on November 17th, 2012): sugar of having a blood test: 6.69mmol/L, after the meal 0.5h12.05mmol/L, after the meal 1h16mmol/L, after the meal 2h17.06mmol/L, after the meal 3h10.61mmol/L on an empty stomach; Look into insulin releasing: fasting insulin 26.57 μ IU/ml, 0.5h41.39 μ IU/ml after the meal, after the meal 1h74.28 μ IU/ml, after the meal 2h49.63 μ IU/ml, after the meal 3h41.38 μ IU/ml.Patient sleeps takes a turn for the better, and still feel spirit tired, xerocheilia, vola is numb, and two just adjust, and light red tongue is dark, white and thin fur, thready and rolling pulse.Continue to keep Sini San and close decoction of four noble drugs, prescription: Radix Bupleuri 10g, Radix Paeoniae Alba 10g, Fructus Aurantii 10g, Radix Glycyrrhizae Preparata 6g, Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Rhizoma Coptidis 20g, Semen Ziziphi Spinosae (parched) 20g, Caulis Polygoni Multiflori 30g, Herba Epimedii 15g, Fructus Amomi 6g, Fructus Schisandrae Chinensis 5g, Stigma Maydis 30g, prepared RADIX ACHYRANTHIS BIDEN-TATAE with salt solution 10g.Every day 1 dose, decocting sub-service sooner or later.Chinese patent drugs for treatment is same examines.Eight examine (on December 29th, 2012): the symptoms such as biped numbness and uneasy sleeping at night are all clearly better, and xerostomia, halitosis recently, diet two is just normal, and spirit takes a turn for the better, red tip of the tongue, white and thin fur, stringy and thready pulse.Continue seven diagnosis and treatment to treat.Nine examine (on January 19th, 2013): look into glycolated hemoglobin 7.3%.Recent operating pressure is large, and xerostomia is thirsty, stomach receive can, extremity to be twitched sense without paralysis, and stool a line every day, urine is yellowish, abnormal smells from the patient is heavy, amount is many, and without nocturia, crouch night conscious fever of the body, and dormancy is pacified, light red tongue, white and thin fur, thready pulse.Decoction of four noble drugs closes with Sini San in side, SHENGMAI SAN adds the product of calming the nerves, with soothing liver and strengthening spleen, and tranquilizing by nourishing the heart, enriching yin boost qi.Prescription: Radix Bupleuri 10g, Radix Paeoniae Alba 10g, Fructus Aurantii 10g, Radix Glycyrrhizae Preparata 6g, Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Rhizoma Coptidis 20g, Semen Ziziphi Spinosae (parched) 20g, Caulis Polygoni Multiflori 30g, Herba Epimedii 15g, Fructus Amomi 6g, Stigma Maydis 30g, Radix Achyranthis Bidentatae 10g, Radix Rehmanniae 20g, Radix Ophiopogonis 30g.Every day 1 dose, decocting sub-service sooner or later.Chinese patent drugs for treatment is same examines.Ten examine (on February 23rd, 2013): xerostomia, halitosis, spiritlessness and weakness, foot fiber crops, sleeps poor, sleep shallow, Yi Xing, urine is highly seasoned, stool normally, light red tongue secretly, white and thin fur, stringy pulse.Keep front scheme continual cure.11 examine (on March 30th, 2013): recently often occur the hypoglycemic reactions such as dizziness, nervous, sweating, self detecting blood sugar 3.0mmol/L, remission after clothes sugar, remaining without uncomfortable.Receive dormancy can, two just adjust, light red tongue, white and thin fur, moderate pulse.Continue to keep front treatment, and advise patient to reduce Chinese patent medicine dose, each 8 of blood sugar lowering SANHUANG PIAN, every day 2 times, each 0.3g of Berberine Tablet, every day 2 times, taking medicine after meal.12 examine (on May 11st, 2013): look into glycolated hemoglobin 6.3%.The hypoglycemic reactions such as easy appearance at dusk is recently weak, sweating, can alleviate after taking sugar.Now receive dormancy can, two just adjust, light red tongue, white and thin fur, stringy and thready pulse.Square with Sini San, lizhong decoction, kidney four taste conjunction side, soothing liver and strengthening spleen, temperature male wind-supplying kidney.Prescription: Radix Glycyrrhizae Preparata 6g, Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae (parched) 30g, Rhizoma Zingiberis 5g, Fructus Psoraleae 15g, Semen Cuscutae 15g, Herba Epimedii 15g, Fructus Lycii 15g, Radix Bupleuri 10g, Radix Paeoniae Rubra 15g, Fructus Amomi 6g, Fructus Aurantii 10g, Radix Curcumae 10g, Endothelium Corneum Gigeriae Galli 10g, Fructus Forsythiae 30g, Spina Gleditsiae 30g.Every day 1 dose, decocting sub-service sooner or later.Advise patient to reduce Chinese patent medicine dose further, give each 4 of blood sugar lowering SANHUANG PIAN, every day 2 times, each 0.1g of Berberine Tablet, every day 2 times, taking medicine after meal.And advise that patient checks carbohydrate tolerance and insulin releasing.13 examine (on June 22nd, 2013): sugar of having a blood test: 6.3mmol/L, after the meal 0.5h9.48mmol/L, after the meal 1h12.87mmol/L, after the meal 2h11.63mmol/L, after the meal 3h7.69mmol/L on an empty stomach; Look into insulin releasing: fasting insulin 18.82 μ IU/ml, 0.5h50.81 μ IU/ml after the meal, after the meal 1h76.81 μ IU/ml, after the meal 2h78.52 μ IU/ml, after the meal 3h46.57 μ IU/ml.Now without significant discomfort, spirit good, without dry mouth with bitter taste, receive dormancy can, two just adjust, pale tongue, white and thin fur, stringy and thready pulse.Suspend Chinese medicine, Chinese patent drugs for treatment is examined with 12.Through the treatment of 11 months, patient's glycolated hemoglobin, carbohydrate tolerance and insulin level all had clear improvement, and follow up a case by regular visits to in October, 2014, patient blood glucose controlled in normal range always.Check a hepatic and renal function per March, all without exception.
medicine pharmacological action
By setting up diabetic cardiopathy animal model, investigation and comparison Jiawei-Taohong-Siwu S oup and the side of tearing open are to the Different therapeutical effect of diabetes and heart change thereof:
1. establish DC rat model: STZDM rat feeding surrounding can occur cardiac damage, accompany weight loss simultaneously, blood glucose increases, cardiac enlargement, T ripple are lifted, implement coronary artery ligation more on this basis, match with clinical DM coronary heart disease feature; And normal group implements coronary ligation art, then with clinical crown cardiopathia feature similarity.Experimental result shows, and DM coronary heart disease, than coronary heart disease, has the features such as myocardial ischemia-area is extensive, degree heavy, heteronomy rate is high, survival rate is low, conforms to clinical report.
2. 1 type/2 type DM rat heart muscle Electronic Speculum change is compared: 2 type cardiac damages are many compared with 1 type quantity, and pathological characters is serious, and cell trend apoptosis.
3. the impact that different method for the treatment of changes 1 type/2 type DM rat model cardiac muscle Electronic Speculum is compared respectively: each treatment group is all improved.1 type+Chinese drug-treated group, to purge heat, catharsis group is improved significantly, and supplementing QI and nourishing YIN group is taken second place; 2 types+Chinese drug-treated group, then improve significantly with blood circulation promoting and blood stasis dispelling group, the catharsis that purges heat takes second place.
4. compare the protective effect of different method for the treatment of to DC acute myocardial ischemia, show with comprehensive, comprehensive+Hirudo group effect is the most obvious.
5. compare different method for the treatment of and block 2 type DM rat height sugar, high fat, Insulin Resistance: 2 type DM models, its rat body weight does not subtract, and serum insulin levels is not low, and blood glucose, blood fat increase, high density lipoprotein reduces companion's insulin sensitivity and declines, and matches with clinical DM pathological characters.Chinese drug-treated group, except comprehensive+Hirudo group, all can stop blood glucose and triglyceride to raise, and can significantly improve high density lipoprotein, at reduction insulin simultaneously, improve insulin sensitivity index further, alleviate insulin resistant, especially with supplementing QI and nourishing YIN group effect stability.
6. different method for the treatment of is compared on DM rat blood serum and the impact of heart tissue oxygen-derived free radicals: result shows traditional Chinese medical science supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, the catharsis method that expels the heat-evil is alone or conjunctive use, all there is Function of Antioxygen Free Radical, and curative effect is better than Western medicine Captopril group in promotion LPO lowers reaction.
7. Jiawei-Taohong-Siwu S oup and different extract is compared on the Fibrotic impact of Myocardium of Diabetic Rats.Result shows, and the total collagen content of Myocardium of Diabetic Rats increases, and III Collagen Type VI content increases, and NTx content reduces, and I/III ratio declines.The full side's decoct of Jiawei-Taohong-Siwu S oup and water extract-alcohol precipitation, n-butanol extract can stop Myocardium of Diabetic Rats collagen paraplasm, and maintain I/ III Collagen Type VI normal ratio, effect is seemingly better than diamicron.
8. the impact on aorta of diabetic rats bow pathological changes of Jiawei-Taohong-Siwu S oup and different extract is compared.Electronic Speculum result shows, the n-butanol extraction composition of Jiawei-Taohong-Siwu S oup has obvious therapeutical effect to aorta of diabetic rats bow pathological changes, and curative effect is close to diamicron.
9. Jiawei-Taohong-Siwu S oup and different extract is compared on the impact of Myocardium of Diabetic Rats pathological changes.Electronic Speculum result show, the n-butanol extraction composition of Jiawei-Taohong-Siwu S oup has obvious therapeutical effect to Myocardium of Diabetic Rats pathological changes, its curative effect and diamicron close.
Drug effect effective site and to diabetic cardiovascular disease become curative effect and study mechanism:
1. the n-butanol extraction composition of Jiawei-Taohong-Siwu S oup has certain therapeutical effect to Myocardium of Diabetic Rats pathological changes, has certain therapeutical effect to aorta of diabetic rats bow pathological changes.
2. the full side's decoct of Jiawei-Taohong-Siwu S oup and water extract-alcohol precipitation, n-butanol extract can stop Myocardium of Diabetic Rats collagen paraplasm, maintain I/III Collagen Type VI normal ratio, and effect is seemingly better than diamicron.
3. the different extract component such as Jiawei-Taohong-Siwu S oup and n-butyl alcohol, water extract-alcohol precipitation, ethyl acetate all has the expression stoping Myocardium of Diabetic Rats GluT4mRNA to decline, and stablizes the effect that it is expressed, best with n-butanol extract effect
4. the different extract component such as the full side of Jiawei-Taohong-Siwu S oup and n-butyl alcohol, water extract-alcohol precipitation, ethyl acetate is improved or stablizes the effect of diabetes rat myocardial cell Na ﹢+-K ﹢+-ATP enzyme and Ca2 ﹢+-atpase activity, thus the pathological change that the myocardial hypertrophy of diabetes rat and cardiac function decline can be stoped to a certain extent. except full side's group, be excellent with the curative effect of n-butyl alcohol and ethyl acetate group in its extract.
5. Jiawei-Taohong-Siwu S oup can by suppressing the macroangiopathy caused by RI induction SMC proliferation function anti-diabetic atherosclerosis, and the active ingredient of we's suppression smooth muscle cell proliferation may be present in invigorates blood circulation+purge heat in catharsis group.
6. by unifying the clinical research of dialectical fractal and statistical analysis coronary angiography data to 91 routine diabetic coronary artery disease patients, comparatively syndrome of deficiency of QI is serious for the coronary atherosclerosis degree of discovery diabetes coronary disease pain patient yang deficiency syndrome, and the coronary atherosclerosis degree there was no significant difference of different mark excess syndrome type.
7. Jiawei-Taohong-Siwu S oup significantly can raise NO content in external HUVEC culture fluid, reduce ET-1 content, may have a better role to endothelial function of diabetes mellitus obstacle, its effective site mainly may be present in the group and adding among taste side's high dose group of invigorating blood circulation, and reduces ICAM-1 effect and then may to be present in except supplementing QI and nourishing YIN group respectively in the side of tearing open.
To being that in the former side institute of making, preparation blood sugar lowering SANHUANG PIAN carries out Clinical and experimental study with Jiawei-Taohong-Siwu S oup, primary study blood sugar lowering SANHUANG PIAN control diabetic cardiopathy comprises curative effect and the mechanism of cardiomyopathy and coronary heart disease, and Mutiple Targets observes the Effect study of this medicine to type 2 diabetes mellitus rat early nephropathy, fatty liver, pancreas simultaneously:
clinical research through following random controls finds, blood sugar lowering SANHUANG PIAN can not only improve the clinical symptoms of diabetes and coronary heart disease, can also improve myocardial ischemia; Obvious reduction E/A ratio, raise end-diastolic footpath, left room numerical value, improve ejection fraction and left LVSF, increase cardiac output, Diastole Function is improved significantly, also has desirable influence to Left ventricular systolic function;
can fat metabolic disturbance be corrected, serum total cholesterol, triglyceride and apolipoprotein B can be reduced, high density lipoprotein increasing, cholesterol and Apolipoprotein A1; Reduce blood glucose, blood pressure and body weight etc.Blood sugar lowering SANHUANG PIAN effectively can improve life quality and the health level of diabetic coronary artery disease patient, and evident in efficacy.All there is not the generation of untoward reaction situation, other severe complications and whole last event in treatment group all patients in whole process treatment, do not have toxic and side effects.
blood sugar lowering SANHUANG PIAN can improve diabetes rat glucose-lipid metabolism disorder, can reduce blood fat, improve insulin resistant, improves adiponectin, leptin content;
in control chronic complicating diseases, type 2 diabetes mellitus left ventricular remodeling in rats can not only be improved, alleviate myocardial ischemia thus cardioprotection, and early diabetic nephropathy rat urine PE can be reduced, delay the progress even reversing early diabetic nephropathy.
The present invention be should be understood that; above-described embodiment; further detailed description has been carried out to object of the present invention, technical scheme and beneficial effect; these are only embodiments of the invention; be not intended to limit the present invention, every within spiritual principles of the present invention, done any amendment, equivalent replacement, improvement etc.; all should be included within protection scope of the present invention, the protection domain that protection scope of the present invention should define with claim is as the criterion.
Claims (4)
1. treat a Chinese medicine for type 2 diabetes mellitus, it is characterized in that, comprise the component of following weight portion:
Radix Et Rhizoma Rhei 20 ~ 50 parts, Radix Rehmanniae 60 ~ 90 parts, Pachyrhizua angulatus 80 ~ 120 parts, the Radix Astragali 100 ~ 150 parts, Radix Ophiopogonis 50 ~ 80 parts, Rhizoma Dioscoreae 80 ~ 120 parts, 10 ~ 30 parts, Radix Glycyrrhizae, Radix Scrophulariae 60 ~ 90 parts, Ramulus Cinnamomi 15 ~ 35 parts, 85 ~ 115 parts, Semen Persicae.
2. the Chinese medicine for the treatment of type 2 diabetes mellitus according to claim 1, is characterized in that, also comprises the component of following weight portion: 20 parts, Poria, Radix Glycyrrhizae Preparata 6 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Pinelliae Preparatum 10 parts, Fructus Aurantii 10 parts, Caulis Bambusae In Taenia 10 parts, Rhizoma Coptidis 20 parts, Pachyrhizua angulatus 30 parts, Radix Scutellariae 10 parts, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 20 parts, Rhizoma Atractylodis 30 parts, Radix Polygoni Multiflori 30 parts, Fructus Crataegi 15 parts, Semen Cassiae 15 parts, Radix Rehmanniae 20 parts, Radix Ophiopogonis 30 parts;
Or
Also comprise the component of following weight portion: 20 parts, Poria, Radix Glycyrrhizae Preparata 6 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Pinelliae Preparatum 10 parts, Fructus Aurantii 10 parts, Caulis Bambusae In Taenia 10 parts, Rhizoma Coptidis 30 parts, Pachyrhizua angulatus 45 parts, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 20 parts, Rhizoma Atractylodis 30 parts, Radix Polygoni Multiflori 30 parts, Semen Cassiae 15 parts, Radix Rehmanniae 20 parts, Radix Ophiopogonis 30 parts, Rhizoma Polygoni Cuspidati 30 parts, Radix Trichosanthis 15 parts, Rhizoma Zingiberis 6 parts;
Or
Also comprise the component of following weight portion: 3 20 parts, Poria, Radix Glycyrrhizae Preparata 6 parts, Pericarpium Citri Reticulatae 6 parts, Rhizoma Coptidis 20 parts, Pachyrhizua angulatus 30 parts, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 20 parts, Rhizoma Atractylodis 30 parts, Radix Polygoni Multiflori 30 parts, Radix Rehmanniae 30 parts, Radix Ophiopogonis 30 parts, Rhizoma Polygoni Cuspidati 30 parts, Radix Trichosanthis 15 parts, Fructus Lycii 15 parts, Flos Buddlejae 15 parts, Semen Celosiae 15 parts.
3. the Chinese medicine for the treatment of type 2 diabetes mellitus according to claim 1, is characterized in that, also comprises the component of following weight portion:
Radix Bupleuri 10 parts, Radix Scutellariae 10 parts, Rhizoma Pinelliae Preparatum 10 parts, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 30 parts, Fructus Jujubae 10 parts, Radix Glycyrrhizae Preparata 6 parts, Pachyrhizua angulatus 30 parts, Rhizoma Coptidis 10 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Polygoni Cuspidati 30 parts, Radix Trichosanthis 15 parts, Stigma Maydis 30 parts, Herba Artemisiae Scopariae 20 parts, Radix Salviae Miltiorrhizae 10;
Or
Radix Bupleuri 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Lycii 15 parts, Flos Chrysanthemi 10 parts, Radix Rehmanniae Preparata 20 parts, Rhizoma Dioscoreae 30 parts, Fructus Corni 15 parts, Cortex Moutan 10 parts, 15 parts, Poria, Rhizoma Alismatis 10 parts, Flos Buddlejae 15 parts, Herba Senecionis Scandentis 15 parts, Fructus Leonuri 15 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts;
Or
Radix Bupleuri 10 parts, Ramulus Cinnamomi 10 parts, Rhizoma Zingiberis 10 parts, Concha Ostreae 30 parts, Radix Trichosanthis 15 parts, Fructus Jujubae 10 parts, Radix Glycyrrhizae Preparata 6 parts, stir-baked RADIX CONDONOPSIS PILOSULAE in rice 30 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts, Rhizoma Atractylodis 30 parts, Rhizoma Coptidis 20 parts, Stigma Maydis 30 parts, Radix Rehmanniae 20 parts, Radix Ophiopogonis 30 parts, Fructus Schisandrae Chinensis 10 parts;
Or
20 parts, Poria, Radix Glycyrrhizae Preparata 6 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Coptidis 20 parts, Pachyrhizua angulatus 30 parts, Radix Scutellariae 10 parts, Radix Codonopsis 20 parts, Rhizoma Atractylodis 30 parts, Rhizoma Polygoni Cuspidati 20 parts, Fructus Crataegi 10 parts, Semen Cassiae 15 parts, Stigma Maydis 30 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts, Radix Rehmanniae 20 parts, Radix Ophiopogonis 20;
Or
20 parts, Poria, Radix Glycyrrhizae Preparata 6 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Coptidis 20 parts, Pachyrhizua angulatus 30 parts, Radix Scutellariae 10 parts, Radix Codonopsis 30 parts, Rhizoma Atractylodis 30 parts, Semen Cassiae 15 parts, Stigma Maydis 30 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts, Radix Rehmanniae 20 parts, Radix Aconiti Lateralis Preparata 6 parts, Rhizoma Zingiberis 6 parts, the Radix Linderae 10;
Or
Ramulus Cinnamomi 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Jujubae 10 parts, Radix Glycyrrhizae Preparata 6 parts, Pachyrhizua angulatus 60 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Alismatis 20 parts, Rhizoma Chuanxiong 10 parts, 30 parts, Poria, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Radix Codonopsis 30 parts, the Radix Astragali 30 parts, 5 parts, Herba Ephedrae, Radix Aconiti Lateralis Preparata 6 parts, Herba Asari 3 parts, 10 parts, Rhizoma Zingiberis Recens;
Or
Radix Bupleuri 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Aurantii 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Codonopsis 30 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 15 parts, Poria, Pachyrhizua angulatus 15 parts, Radix Scutellariae 10 parts, Rhizoma Coptidis 20 parts, Semen Ziziphi Spinosae (parched) 20 parts, Caulis Polygoni Multiflori 30 parts, Spica Prunellae 15 parts, Rhizoma Pinelliae Preparatum 15 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts;
Or
Radix Bupleuri 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Aurantii 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Codonopsis 30 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 15 parts, Poria, Rhizoma Coptidis 20 parts, Semen Ziziphi Spinosae (parched) 20 parts, Caulis Polygoni Multiflori 30 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts, Fructus Schisandrae Chinensis 5 parts, Stigma Maydis 30 parts, prepared RADIX ACHYRANTHIS BIDEN-TATAE with salt solution 10 parts;
Or
Radix Bupleuri 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Aurantii 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Codonopsis 30 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 15 parts, Poria, Rhizoma Coptidis 20 parts, Semen Ziziphi Spinosae (parched) 20 parts, Caulis Polygoni Multiflori 30 parts, Herba Epimedii 15 parts, Fructus Amomi 6 parts, Stigma Maydis 30 parts, Radix Achyranthis Bidentatae 10 parts, Radix Rehmanniae 20 parts, Radix Ophiopogonis 30 parts;
Or
Radix Glycyrrhizae Preparata 6 parts, Radix Codonopsis 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, Rhizoma Zingiberis 5 parts, Fructus Psoraleae 15 parts, Semen Cuscutae 15 parts, Herba Epimedii 15 parts, Fructus Lycii 15 parts, Radix Bupleuri 10 parts, Radix Paeoniae Rubra 15 parts, Fructus Amomi 6 parts, Fructus Aurantii 10 parts, Radix Curcumae 10 parts, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Forsythiae 30 parts, Spina Gleditsiae 30 parts.
4. a preparation technology for the Chinese medicine of the arbitrary described treatment type 2 diabetes mellitus of claims 1 to 3, is characterized in that, get Rhizoma Dioscoreae, be ground into powdery, nine tastes such as all the other Radix Et Rhizoma Rhei decoct with water secondary, 1.5 hours first times, second time 1 hour, merge secondary decocting liquid, filter, filtrate is concentrated into thick paste, adds above-mentioned Rhizoma Dioscoreae fine powder, mixing, dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510704306.XA CN105125851A (en) | 2015-10-27 | 2015-10-27 | Traditional Chinese medicine treating 2-type diabetes and preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510704306.XA CN105125851A (en) | 2015-10-27 | 2015-10-27 | Traditional Chinese medicine treating 2-type diabetes and preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105125851A true CN105125851A (en) | 2015-12-09 |
Family
ID=54711664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510704306.XA Pending CN105125851A (en) | 2015-10-27 | 2015-10-27 | Traditional Chinese medicine treating 2-type diabetes and preparation technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105125851A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816664A (en) * | 2016-05-20 | 2016-08-03 | 何宏继 | Traditional Chinese medicine composition for treating metabolic syndrome and preparing method thereof |
| CN106138696A (en) * | 2016-08-16 | 2016-11-23 | 安徽天乾健食品科技有限公司 | A kind of prescription treating asthenic cold type diabetes and preparation method thereof |
| CN106237182A (en) * | 2016-08-31 | 2016-12-21 | 陈钢义 | A kind of Chinese medicine composition treating diabetes and capsule thereof and preparation method |
| CN106491990A (en) * | 2016-12-05 | 2017-03-15 | 童守信 | A kind of Chinese medicine composition for treating diabetes B |
| CN113425795A (en) * | 2021-02-25 | 2021-09-24 | 广州中医药大学第一附属医院 | Application of sanhuang hypoglycemic tablets in preparation of medicine for treating type 2diabetes and osteoporosis |
-
2015
- 2015-10-27 CN CN201510704306.XA patent/CN105125851A/en active Pending
Non-Patent Citations (17)
| Title |
|---|
| 储全根等: "加味桃核承气汤及其不同提取物对糖尿病大鼠心肌细胞GluT4mRNA表达的影响", 《中国中医基础医学杂志》 * |
| 储全根等: "加味桃核承气汤及其不同提取物对糖尿病大鼠心肌细胞钙转运的影响", 《中国中医药信息杂志》 * |
| 李赛美: "中医治疗糖尿病再实践再思考", 《全国第二十二次仲景学说学术年会论文集》 * |
| 李赛美等: "不同治法对糖尿病大鼠心脏病变影响的实验研究", 《新中医》 * |
| 李赛美等: "不同造模法糖尿病大鼠心肌电镜观察及对中药效应的影响", 《中国中医基础医学杂志》 * |
| 李赛美等: "加味桃核承气汤及不同提取物对糖尿病大鼠心肌纤维化的影响", 《南京中医药大学学报》 * |
| 李赛美等: "加味桃核承气汤及其不同提取物对糖尿病大鼠心肌细胞超微结构的影响", 《北京中医药大学学报》 * |
| 李赛美等: "加味桃核承气汤及其拆方对糖尿病损伤HUVEC培养液中tPA和PAI-1含量的影响", 《第十次全国中医糖尿病大会论文集》 * |
| 李赛美等: "加味桃核承气汤及其提取物对糖尿病大鼠主动脉弓超微结构的影响", 《广州中医药大学学报》 * |
| 李赛美等: "加味桃核承气汤对糖尿病大鼠冠状动脉结扎致心肌缺血预防作用的研究", 《中医杂志》 * |
| 李赛美等: "卡托普利对糖尿病大鼠高糖高脂及胰岛素抵抗的实验研究", 《实用医学杂志》 * |
| 李赛美等: "桃核承气汤防治糖尿病及其并发症研究概况及展望", 《中华中医药学刊》 * |
| 熊曼琪等: "加味桃核承气汤（片）治疗糖尿病临床疗效观察", 《新中医》 * |
| 熊曼琪等: "加味桃核承气汤治疗II型糖尿病的临床和实验研究", 《中国中西医结合杂志》 * |
| 熊曼琪等: "脾虚是消渴病的重要病机", 《广州中医学院学报》 * |
| 郑海霞: "三黄降糖片对糖尿病视网膜病非酶糖化影响的临床研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 陈延: "《陈延：好脾胃 不生病》", 28 February 2015, 羊城晚报出版社 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816664A (en) * | 2016-05-20 | 2016-08-03 | 何宏继 | Traditional Chinese medicine composition for treating metabolic syndrome and preparing method thereof |
| CN105816664B (en) * | 2016-05-20 | 2019-04-09 | 何宏继 | A kind of Chinese medicine composition and preparation method thereof for treating metabolic syndrome |
| CN106138696A (en) * | 2016-08-16 | 2016-11-23 | 安徽天乾健食品科技有限公司 | A kind of prescription treating asthenic cold type diabetes and preparation method thereof |
| CN106237182A (en) * | 2016-08-31 | 2016-12-21 | 陈钢义 | A kind of Chinese medicine composition treating diabetes and capsule thereof and preparation method |
| CN106491990A (en) * | 2016-12-05 | 2017-03-15 | 童守信 | A kind of Chinese medicine composition for treating diabetes B |
| CN106491990B (en) * | 2016-12-05 | 2019-09-03 | 童守信 | A kind of Chinese medicine composition for treating diabetes B |
| CN113425795A (en) * | 2021-02-25 | 2021-09-24 | 广州中医药大学第一附属医院 | Application of sanhuang hypoglycemic tablets in preparation of medicine for treating type 2diabetes and osteoporosis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1742939B (en) | Medicine for treating pulmonary fibrosis and preparing method | |
| CN102327569B (en) | Preparation method and application method of drug and herbal medicine thereof for curing chronic hepatitis B | |
| CN103071128B (en) | Externally-applied plaster for curing dysmenorrhea | |
| CN105125851A (en) | Traditional Chinese medicine treating 2-type diabetes and preparation technology | |
| CN102772748B (en) | Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN103386008A (en) | Chinese medicine composition for treating endocrine dyscrasia | |
| CN103920028A (en) | Pharmaceutical composition for treating diabetes and preparation method of preparation thereof | |
| CN102940785B (en) | Traditional Chinese medicine composition for treating vertigo | |
| CN103623292A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN100522226C (en) | Composition of Chinese traditional medicine for treating coronary heart disease | |
| CN104815166A (en) | Traditional Chinese medicine composition for treating diabetes as well as preparation and application of traditional Chinese medicine composition | |
| CN103006989B (en) | Medical composition for treating diabetic nephropathy | |
| CN105055915A (en) | Traditional Chinese medicine composition for treating hypertension | |
| CN103990078A (en) | Traditional Chinese medicine composition for treating jaundice hepatitis | |
| CN100509025C (en) | A medicine for treating diabetes | |
| CN103285343B (en) | Medicine for treating liver cancer and preparation method thereof | |
| CN101926903A (en) | Chinese medicine preparation for curing facial paralysis | |
| CN101549045B (en) | Traditional Chinese medicine preparation for treating diabetes and preparation method thereof | |
| CN103638389A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN105250954B (en) | A kind of Chinese medicine for treating IBS and preparation method thereof | |
| CN104940516B (en) | A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application | |
| CN101264237A (en) | Medicaments assembly for recuperating sub-health and preparation thereof | |
| CN1149095C (en) | Chinese medicine for treating baby's congenital heart disease | |
| CN108853340A (en) | A kind of Chinese medicine of nourishing the liver and kidney and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151209 |