CN104940516B - A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application - Google Patents
A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application Download PDFInfo
- Publication number
- CN104940516B CN104940516B CN201510313857.3A CN201510313857A CN104940516B CN 104940516 B CN104940516 B CN 104940516B CN 201510313857 A CN201510313857 A CN 201510313857A CN 104940516 B CN104940516 B CN 104940516B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese
- root
- aplastic anemia
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of Chinese medicine compositions for treating chronic aplastic anemia, it includes following component：Prepared rehmannia root, Chinese yam, Fructus Corni, Poria cocos, prepared fleece flower root, the fruit of glossy privet, eclipta, psoralea corylifolia, thizoma curculiginis, Herba Epimedii, deer horn glue, Herba Cistanches, dried human placenta, RADIX ANGELICAE SINEINSIS, Caulis Spatholobi, raw Radix Astragali, ginseng, cooked aconite, Chinese cassia tree, Glabrous Sarcandra Herb, selfheal, desmodium, tripterygium wilfordii, honey-fried licorice root.The invention also discloses the preparation method and application of the Chinese medicine composition of above-mentioned treatment chronic aplastic anemia.The inventive formulation CAA tool invalid to conventional western medicine treatment has a better effect, and without obvious adverse reaction, embody the advantage of the intractable CAA of Chinese medicine.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating chronic aplastic anemia
And preparation method and application.
Background technology
Alpastic anemia (aplastic anemia, AA) is a kind of marrow hematopoiesis function failure disease, is mainly shown as
Hemopoietic hypofunction of marrow, whole blood trace elements and anaemia, bleeding, infection syndrome.Wherein chronic aplastic anemia
(Chronic Aplastic Anemia, CAA) is that a kind of morbidity is slow, and the course of disease is relatively long, it is very difficult to the blood system for the treatment of
System disease, doctor trained in Western medicine more options androgen and ciclosporin in treating.CAA belongs to the traditional Chinese medical science " marrow labor disease " scope, is that the traditional Chinese medical science is hemopathic heavy
One of point and advantage disease.TCM investigation AA has the history of nearly 60 years, from the syndrome differentiation of zang-fu viscera of initial analysing and differentiating the pathological condition finally, especially
It is the combination of Chinese tradiational and Western medicine parting standard that AA is drafted in nineteen eighty-two First National traditional Chinese and western medicine blood disease forum, from this Chinese medicine
AA achieves positive effect.If 30 CAA patients treat in the simple Chinese medicine ginseng cornel side of enriching blood, 2 courses for the treatment of cure 8 substantially later,
Effective 8, effective 5, no effect 9, total effective rate 70%[1].Suhl cloud etc.[2]Suppression is immunized with Chinese medicine joint androgen in treating
The invalid SAA62 examples of preparation, it is basic to cure 12 (19.4%) through the treatment of 6-57 months, alleviate 14 (22.6%), it is bright
Aobvious progress 8 (12.9%), invalid 28 (45.2%), total effective rate 54.8%.With reference to morbidity machine of the modern medicine about AA
System, it is believed that conventional help therapy still has certain limitation.
Invention content
The technical problems to be solved by the invention are the complicated sexual compatibilities of the interpretation of the cause, onset and process of an illness and pathological factor based on CAA using multiple method
Generous treatment, so as to provide a kind of Chinese medicine composition for treating chronic aplastic anemia, which has warm kidney
The effect of invigorating the spleen, Fuzheng Jiedu.
The present invention also technical problems to be solved are to provide the preparation method of above-mentioned Chinese medicine composition.
Last technical problems to be solved of the invention are to provide the application of above-mentioned Chinese medicine composition.
In order to solve the above technical problems, the technical solution adopted by the present invention is as follows：
A kind of Chinese medicine composition for treating chronic aplastic anemia, it includes the component of following parts by weight：Cultivated land
It is 10-150 parts yellow, 10-150 parts of Chinese yam, 10-150 parts of Fructus Corni, 10-150 parts of Poria cocos, 5-50 parts of prepared fleece flower root, fruit of glossy privet 10-
150 parts, 15-150 parts of eclipta, 10-150 parts of psoralea corylifolia, 10-150 parts of thizoma curculiginis, 10-150 parts of Herba Epimedii, deer horn glue 5-50
Part, 5-50 parts of Herba Cistanches, 5-50 parts of dried human placenta, 5-50 parts of RADIX ANGELICAE SINEINSIS, 10-150 parts of Caulis Spatholobi, raw 10-150 parts of Radix Astragali, ginseng
3-25 parts, 0.6-10 parts of cooked aconite, 0.6-15 parts of Chinese cassia tree, 10-150 parts of Glabrous Sarcandra Herb, 5-50 parts of selfheal, desmodium 15-150
Part, 3-15 parts of tripterygium wilfordii, 1-30 parts of honey-fried licorice root.
The Chinese medicine composition of above-mentioned treatment chronic aplastic anemia preferably includes the component of following parts by weight：It is ripe
10-75 parts of glutinous rehmannia, 10-75 parts of Chinese yam, 10-75 parts of Fructus Corni, 10-75 parts of Poria cocos, 5-25 parts of prepared fleece flower root, fruit of glossy privet 10-75
Part, 15-75 parts of eclipta, 10-75 parts of psoralea corylifolia, 10-75 parts of thizoma curculiginis, 10-75 parts of Herba Epimedii, 5-25 parts of deer horn glue, Herba Cistanches
5-30 parts, 5-30 parts of dried human placenta, 5-30 parts of RADIX ANGELICAE SINEINSIS, 10-75 parts of Caulis Spatholobi, raw 10-75 parts of Radix Astragali, 3-15 parts of ginseng is ripe attached
It is 0.6-5 parts sub-, 0.6-7 parts of Chinese cassia tree, 10-75 parts of Glabrous Sarcandra Herb, 5-25 parts of selfheal, 10-75 parts of desmodium, 3-15 parts of tripterygium wilfordii,
3-15 parts of honey-fried licorice root.
The Chinese medicine composition of above-mentioned treatment chronic aplastic anemia most preferably includes the component of following parts by weight：
30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta,
15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, chicken
15 parts of blood rattan, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, desmodium 30
Part, 5 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
Above-mentioned most preferably formula can make the appropriate adjustments according to the situation of patient, such as：
For deficiency of vital energy severe one (deficiency of vital energy severe one, show as weak burnout, voice be humble, dynamic then sweating, arteries and veins dizziness nihility power),
The Chinese medicine composition of above-mentioned treatment chronic aplastic anemia most preferably includes the component of following parts by weight：Prepared rehmannia root 30
Part, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta, psoralea corylifolia 15
Part, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, Caulis Spatholobi 15
Part, raw 30 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium, Thunder God
5 parts of rattan, 3-6 parts of honey-fried licorice root.
For deficiency of blood severe one (it is light, dizzy to show as lustreless complexion, lip color for deficiency of blood severe one), above-mentioned treatment is chronic
The Chinese medicine composition of alpastic anemia most preferably includes the component of following parts by weight：30 parts of prepared rehmannia root, 30 parts of Chinese yam,
30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis are excessive
15 parts of the sheep leaves of pulse plants, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, 30 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali,
5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium, 5 parts of tripterygium wilfordii, honey-fried licorice root 3-
6 parts.
For deficiency of Yin severe one (it is thin to show as dysphoria in chestpalms-soles, hectic fever night sweat, mouth parched and tongue scorched, arteries and veins for deficiency of Yin severe one), above-mentioned treatment
The Chinese medicine composition of chronic aplastic anemia most preferably includes the component of following parts by weight：30 parts of prepared rehmannia root, Chinese yam 30
Part, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 30 parts of the fruit of glossy privet, 30 parts of eclipta, 15 parts of psoralea corylifolia, thizoma curculiginis 15
Part, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, 15 parts of Caulis Spatholobi, raw Radix Astragali 15
Part, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium, 5 parts of tripterygium wilfordii, toast are sweet
It is 3-6 parts careless.
For deficiency of yang severe one (it is micro- powerless to show as aversion to cold and cold limbs, pale complexion, clear abundant urine, deeptensepulse for deficiency of yang severe one), on
The Chinese medicine composition for the treatment of chronic aplastic anemia is stated, most preferably includes the component of following parts by weight：Prepared rehmannia root 30
Part, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta, psoralea corylifolia 15
Part, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 15 parts of Herba Cistanches, 30 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, Caulis Spatholobi 15
Part, raw 15 parts of Radix Astragali, 5 parts of ginseng, 10 parts of cooked aconite, 5 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium, thunder
Public 5 parts of rattan, 3-6 parts of honey-fried licorice root.
For heat toxin severe one, (heat toxin severe one shows as irritated coma, thirst and desire for cold drink, scanty drak urine, big constipation or companion and goes out
Blood, rapid pulse are strong), the Chinese medicine composition of above-mentioned treatment chronic aplastic anemia, most preferably including following parts by weight
Component：30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, eclipta
30 parts, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, RADIX ANGELICAE SINEINSIS 10
Part, 15 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 30 parts of Glabrous Sarcandra Herb, 15 parts of selfheal, money
60 parts of grass, 10 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
CAA belongs to the scopes such as the traditional Chinese medical science " consumptive disease ", " marrow labor ", " blood trouble ".It is diseases caused by external factors six external factors which cause diseases cult poison, internal injury seven that it, which is fallen ill mostly,
The factors such as feelings, eating and drinking without temperance, overstrain undermine the five internal organs such as spleen kidney and cause consumptive disease, and especially congenital nephrons is empty long, are difficult warm support
Whole body internal organs, qi and blood is difficult biochemistry, therefore treats more " kidney treating therapies "[7-8].It has been recognised by the inventors that the cause of disease hindered again, on the one hand due to
Healthy tendency is lost, it is impossible to resist exopathogen, the cult poison visitor that takes advantage of a weak point in opponent's defence enters, and further consumes healthy tendency, influences blood metaplasia；On the other hand due to heresy
Poison invagination, ying blood of burning, Jiao Zusui roads make raw ecchymosis or undermine first the foundation of acquired constitution, hinder essence consumption marrow, so that the weary source of green blood.Cause
This, because void is contaminated, because poison is more empty, forms vicious circle.As it can be seen that void, poison, the stasis of blood etc. are the major pathogenetic factor of the disease, the interpretation of the cause, onset and process of an illness
With this void with marking real Variation Features, simple qi-restoratives is difficult to demand perfection in the treatment.In view of the CAA courses of disease with the passing of time, the interpretation of the cause, onset and process of an illness it is complicated,
Become the features such as disease is numerous, touching refractory, it is proposed that multiple method is generous to treat the disease.
Our compound is made of 24 taste Chinese medicines, using tonifying speen and tonifying kidney as this, cooperation removing toxic substances, promoting blood circulation, and based on this void of spleen kidney,
It is real to take into account the marks such as volt poison, hemostasis, the complicated pathological factor of CAA is defeated in detail.《Shen Shi honors life book miscellaneous diseases source stream rhinoceros candle is empty
Damage labor illness source stream》" visceral stroage, vital essence nothing but, institute is so that damage person, says the deficiency of vital energy to cloud, the deficiency of blood, the deficiency of Yin, the deficiency of yang.Yang-energy, cloudy blood,
Essence again for blood this, not from qi and blood, regardless of extreme misery, and the deficiency of yang, the deficiency of Yin then all belong to kidney, deficiency of yang person, kidney-Yang void in kidney, the deficiency of Yin
Person, it is Kidney-Yin empty in kidney." CAA pathological characteristic for Haematopoietic failure and essence lose blood it is few, kidney yin is the material base of hematopoiesis, kidney yang
The power of blood metaplasia, causing has because in the moon, also having because in positive person, pathogenesis varies with each individual the reason of hindering again, have it is evil because
Empty and visitor has blood stasis of blood due to void, be unable to do without the essence of its kidney deficiency.Therefore, the treatment key of CAA is that help is congenital, and
The key of kidney tonifying is adjustment equilibrium between yin and yang, and above-mentioned relative medicine is adjusted flexibly according to individual patients situation in clinic in we
Dosage and compatibility, to be reached " yin and yang in equilibrium " by " treating YANG within YIN, treating YIN within YANG ".《The new side eight of Jing Yue's complete work is omited》It is so-called：
" all deficiency of vital energy persons preferably mend thereon, ginseng, Radix Astragali category be；Smart void person is preferably mended under it, cultivated land, matrimony vine category be；Deficiency of yang person
It preferably mends and simultaneous Warm, osmanthus, attached, rhizoma zingiberis category are；Deficiency of Yin person preferably mend and and it is clear, Men Dong, Chinese herbaceous peony, Radix Rehmanniae category be this Gu Yin
Sun is distinguished.It has gas void person due to essence, works as certainly and mends essence to change gas；Essence void person due to gas, from when tonifying Qi is with production of sperm.There is positive mistake again
It is cloudy and from person, the gas being scattered and lost how is received in not tonifying yinWater catches fire and the vanquished, does not mend fiery He Yi Sue and hangs down quiet the moonThis YIN and YANG promoting each other it
Magical effect.Therefore kind yang-tonifying person, treating YANG within YIN must be intended to, then it is positive to obtain cloudy help and biochemical infinite, kind tonifying yin person, treating YIN within YANG must be intended to, then
Cloudy positive life and fountainhead is inexhaustible ".Research shows that kidney tonifying drug can increase candidate stem cell number, improve bone marrow microenvironment, carry
High immunity of organisms, or even bone marrow cell DNA can be stimulated to synthesize[9-10], the traditional Chinese medical science it is so-called " QI of five ZANG-organs circulating normally, people i.e. pacify and ".Chicken
Blood rattan, Chinese angelica blood supplementing, promoting blood circulation, blood-nourishing, it is intended that eliminating evil life is new, and to reach the purpose of " lead to for use ", experimental study shows promoting blood circulationization
Stasis of blood Chinese medicine can not only improve marrow stromal cell, promote matrix growth, moreover it is possible to stimulate hematopoietic progenitor proliferation, divide
Change[11-12]；Glabrous Sarcandra Herb, selfheal, desmodium, tripterygium wilfordii etc. are clearing heat and detoxicating, it is intended that dispel visitor's heresy of invagination blood system, marrow to bone
The infringement of marrow, i.e. " Xie Quze Zhengan County ".All medicines share, negative and positive play warming kidney and strengthening spleen, life essence-filling, marrow-benefitting, benefiting qi and nourishing blood, eliminating evil altogether with mending
The work(of removing toxic substances.Heat-clearing and detoxifying drug not only has facilitation to hematopoiesis[13], also have to adjust to the immune system of body and make
With[14].It is analyzed by the traditional Chinese and western medicine of above-mentioned medication, 24 taste of the party takes into account the pathological factors such as CAA void, poison, the stasis of blood, acts on and make comprehensively
Hemocytoblast, hematopoieticmicroenviron-ment often and immune function each link, be worth carry out large sample, multicenter, random controls clinic
Experimental study.
Inventive formulation,
Monarch drug in a prescription：Prepared rehmannia root.Prepared rehmannia root, energy nourishing kidney yin, nourishing the liver blood, Tianjing Busuiye medicinal.
Ministerial drug：Fructus Corni, it is sour and astringent warm-natured, there are help, astringent method kidney essense, while tonifying liver blood, The liver and the kidney have a common source, and kidney essense is again
Being continuously replenished for liver blood is relied on, then kidney essense is sufficient for liver blood abundance.Poria cocos, Chinese yam, energy tonifying spleen are reinforced the kidney, the spleen being the foundation of acquired constitution, temper
Abundance is attributed to kidney under the essence of five ZANG-organs and six FU-organs, can increase the effect for nourishing benefiting kidney-essence.Prepared fleece flower root filling liver kidney, benefiting essence-blood；It is purple
River vehicle blood-nourishing, strengthening the essence.All medicines share plays benefiting kidney-essence altogether.Fruit of glossy privet kidney tonifying enriching yin is nourished the liver to improve visual acuity；Eclipta nourishes liver
Kidney, cooling blood and hemostasis；Two medicines share, nourishing liver and kidney the moon.Deer horn glue：Warm filling liver kidney, strengthening the essence blood-nourishing；Herba Cistanches, kidney-replenishing, strengthening the essence
Blood；Cooked aconite recuperating depleted yang, mends fire supporing yang, eliminating cold to stop pain；Chinese cassia tree complement sun, warming spleen and stomach；Psoralea corylifolia tonifying kidney and strengthening yang, controlling nocturnal emission with astringent drugs；It is celestial
Mao Wen kidney yangs are strengthened, Herba Epimedii tonifying kidney and strengthening yang.The work(of warming kidney and enhancing body is played altogether.Raw Radix Astragali, ginseng reinforce vital energy, and veins takes off admittedly has
The benefits of tonifying Qi of the kidney.
Adjutant：RADIX ANGELICAE SINEINSIS, Caulis Spatholobi is promoting blood circulation and removing blood stasis, tonifies the blood and arrest bleeding, and eliminating evil life is new.Glabrous Sarcandra Herb, selfheal, desmodium, thunder
Public rattan, it is clearing heat and detoxicating, it is intended that dispel visitor's heresy of invagination blood system, marrow, i.e., " Xie Quze Zhengan County ".
Make medicine：Honey-fried licorice root coordinating the drug actions of a prescription, to make medicine.
The preparation method of the Chinese medicine composition of above-mentioned treatment chronic aplastic anemia, by the prepared rehmannia root of formula ratio, mountain
Medicine, Poria cocos, prepared fleece flower root, the fruit of glossy privet, eclipta, psoralea corylifolia, thizoma curculiginis, Herba Epimedii, Herba Cistanches, dried human placenta, is worked as at Fructus Corni entirely
Return, Caulis Spatholobi, give birth to Radix Astragali, ginseng, cooked aconite, Chinese cassia tree, Glabrous Sarcandra Herb, selfheal, desmodium, tripterygium wilfordii and honey-fried licorice root mixing, it is cold
Water impregnates 30min, and after being boiled by fire, small fire decocts 1-2h, continuous to decoct 2 times, and Chinese cassia tree is 10 minutes before the 2nd decoction is completed
It adds in and decocts, merge and decoct liquid, wherein, traditional Chinese medicine decoction is taken after mixing it with water after deer horn glue smelt.
The Chinese medicine composition of above-mentioned treatment chronic aplastic anemia is preparing treatment chronic aplastic anemia disease
Application in drug is also within protection scope of the present invention.
Wherein, the drug, dosage form are decoction, tablet, granule or capsule.Appropriate excipient substance can be added
Prepare above-mentioned regular dosage form.
Advantageous effect：Chronic aplastic anemia (CAA) is that a kind of morbidity is slow, and the course of disease is long, it is difficult to the blood for the treatment of
Disease.Western medical treatment is based on hormone, immunosuppressor at present, and curative effect individual difference is larger, and side effect is apparent.The present invention is logical
Crossing clinical test proves, we's CAA tool invalid to conventional western medicine treatment has a better effect, and without obvious adverse reaction, body
The advantage of the intractable CAA of Chinese medicine is showed.
Specific embodiment
According to following embodiments, the present invention may be better understood.It is however, as it will be easily appreciated by one skilled in the art that real
It applies the described content of example and is merely to illustrate the present invention, without sheet described in detail in claims should will not be limited
Invention.
Embodiment 1：
A kind of Chinese medicine composition for treating chronic aplastic anemia includes the component of following parts by weight：
30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, ink drought
30 parts of lotus, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta are worked as entirely
Return 10 parts, 15 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal,
30 parts of desmodium, 5 parts of tripterygium wilfordii, 5 parts of honey-fried licorice root.
Preparation method：By the prepared rehmannia root of formula ratio, Chinese yam, Fructus Corni, Poria cocos, prepared fleece flower root, the fruit of glossy privet, eclipta, benefit
Bone fat, thizoma curculiginis, Herba Epimedii, Herba Cistanches, dried human placenta, RADIX ANGELICAE SINEINSIS, Caulis Spatholobi, raw Radix Astragali, ginseng, cooked aconite, Chinese cassia tree, Glabrous Sarcandra Herb,
Selfheal, desmodium, tripterygium wilfordii and honey-fried licorice root mixing, cold water soak 30min, after being boiled by fire, small fire decocts 1-2h, continuous to decoct
It boils 2 times, Chinese cassia tree adds in decoction in 10 minutes before decocting completion at the 2nd time, merges and decocts liquid；Traditional Chinese medicine decoction rushes after deer horn glue smelt
Clothes.
Embodiment 2：
A kind of Chinese medicine composition for treating chronic aplastic anemia includes the component of following parts by weight：
30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, ink drought
30 parts of lotus, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta are worked as entirely
Return 10 parts, 15 parts of Caulis Spatholobi gives birth to 30 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, selfheal 10
Part, 30 parts of desmodium, 5 parts of tripterygium wilfordii, 3 parts of honey-fried licorice root.
The preparation method is the same as that of Example 1.
We are suitable for deficiency of vital energy severe one, and (it is dizzy empty to show as humble weak burnout, voice, dynamic then sweating, arteries and veins for deficiency of vital energy severe one
It is powerless).
Embodiment 3：
A kind of Chinese medicine composition for treating chronic aplastic anemia includes the component of following parts by weight：
30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, ink drought
30 parts of lotus, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta are worked as entirely
Return 10 parts, 30 parts of Caulis Spatholobi gives birth to 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, selfheal 10
Part, 30 parts of desmodium, 5 parts of tripterygium wilfordii, 6 parts of honey-fried licorice root.
The preparation method is the same as that of Example 1.
We are suitable for for deficiency of blood severe one (it is light, dizzy to show as lustreless complexion, lip color for deficiency of blood severe one).
Embodiment 4：
A kind of Chinese medicine composition for treating chronic aplastic anemia includes the component of following parts by weight：
30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 30 parts of the fruit of glossy privet, ink drought
30 parts of lotus, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta are worked as entirely
Return 10 parts, 15 parts of Caulis Spatholobi gives birth to 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, selfheal 10
Part, 30 parts of desmodium, 5 parts of tripterygium wilfordii, 3 parts of honey-fried licorice root.
The preparation method is the same as that of Example 1.
We are suitable for deficiency of Yin severe one (it is thin to show as dysphoria in chestpalms-soles, hectic fever night sweat, mouth parched and tongue scorched, arteries and veins for deficiency of Yin severe one).
Embodiment 5：
A kind of Chinese medicine composition for treating chronic aplastic anemia includes the component of following parts by weight：
30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, ink drought
30 parts of lotus, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 15 parts of Herba Cistanches, 30 parts of dried human placenta are worked as entirely
Return 10 parts, 15 parts of Caulis Spatholobi gives birth to 15 parts of Radix Astragali, 5 parts of ginseng, 10 parts of cooked aconite, 5 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, selfheal 10
Part, 30 parts of desmodium, 5 parts of tripterygium wilfordii, 5 parts of honey-fried licorice root.
The preparation method is the same as that of Example 1.
We are suitable for for deficiency of yang severe one, (deficiency of yang severe one shows as aversion to cold and cold limbs, pale complexion, clear abundant urine, deeptensepulse
It is micro- powerless).
Embodiment 6：
A kind of Chinese medicine composition for treating chronic aplastic anemia includes the component of following parts by weight：
30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, ink drought
30 parts of lotus, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta are worked as entirely
Return 10 parts, 15 parts of Caulis Spatholobi gives birth to 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 30 parts of Glabrous Sarcandra Herb, selfheal 15
Part, 60 parts of desmodium, 10 parts of tripterygium wilfordii, 5 parts of honey-fried licorice root.
The preparation method is the same as that of Example 1.
We are suitable for for heat toxin severe one, (heat toxin severe one shows as irritated coma, thirst and desire for cold drink, scanty drak urine, stool
Secret or with bleeding, rapid pulse is strong).
Embodiment 7：Barrier (mixture) is put down in blood-nourishing.
A kind of compound composite medicament for treating chronic aplastic anemia includes each component of following parts by weight：It is ripe
30 parts of glutinous rehmannia, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta, Psoralen
15 parts of fat, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, Caulis Spatholobi
15 parts, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium,
5 parts of tripterygium wilfordii, 3 parts of honey-fried licorice root.
In prescription ratio, more than Chinese medicine drink is weighed, is prepared by following techniques.1. people participates in 10 times of amount water extractions two in side
Secondary, filtration takes filtrate spare.2. in addition to deer horn glue, Chinese cassia tree, add the water of 10 times of amounts of medicine materical crude slice total amount, impregnate 30min, heating decocts 1
Hour, filtration, filter residue adds 10 times of amount water heating to decoct 1 hour again, and filtration merges filtrate twice, adds in ginseng decoction liquor, then add
Enter deer horn glue, make dissolve fully, and be concentrated into appropriate.3. after separately suitable quantity of water being taken to boil, adding in Chinese cassia tree, slightly boiling 10min, filter are kept
Take filtrate.4. Chinese cassia tree extracting solution is added in above-mentioned concentrate, adjusting is added water to appropriate, packing, flowing steam sterilization
30min, you can.
:Embodiment 8：Syrup.
A kind of compound composite medicament for treating chronic aplastic anemia includes each component of following parts by weight：It is ripe
40 parts of glutinous rehmannia, 20 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta, Psoralen
15 parts of fat, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 15 parts of deer horn glue, 15 parts of Herba Cistanches, 15 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, Caulis Spatholobi
15 parts, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium,
5 parts of tripterygium wilfordii, 3 parts of honey-fried licorice root.
In prescription ratio, more than Chinese medicine drink is weighed, is prepared by following techniques.1. people participates in 12 times of amount water extractions two in side
Secondary, filtration takes filtrate spare.2. in addition to deer horn glue, Chinese cassia tree, add the water of 12 times of amounts of medicine materical crude slice total amount, impregnate 60min, heating decocts
1.5 hours, filtration, filter residue added 12 times of amount water heating to decoct 1.5 hours again, and filtration merges filtrate twice, adds in ginseng and decocts
Liquid adds deer horn glue, makes dissolve fully, and is concentrated into appropriate.3. after separately suitable quantity of water being taken to boil, adding in Chinese cassia tree, slightly boiling is kept
10 minutes, leaching filtrate.4. Chinese cassia tree extracting solution is added in above-mentioned concentrate, simple syrup is added in, adds water adjusting to appropriate, point
Dress, flowing steam sterilization 30 minutes, you can.
Embodiment 9：Granule.
A kind of compound composite medicament for treating chronic aplastic anemia includes each component of following parts by weight：It is ripe
40 parts of glutinous rehmannia, 40 parts of Chinese yam, 40 parts of Fructus Corni, 20 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta, Psoralen
10 parts of fat, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 15 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, Caulis Spatholobi
15 parts, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium,
5 parts of tripterygium wilfordii, 3 parts of honey-fried licorice root.
In prescription ratio, more than Chinese medicine drink is weighed, is prepared by following techniques.1. people participates in 12 times of amount water extractions two in side
Secondary, filtration takes filtrate spare.2. in addition to deer horn glue, Chinese cassia tree, add 10 times of bulk pharmaceutical chemicals total weight to measure water, decoct extraction 3 times, often
Secondary 1 hour.Collecting decoction is concentrated into relative density 1.10 (60 DEG C survey), adds ethyl alcohol to alcohol content up to 60%, stand 12 hours with
On.Leaching supernatant, recycling ethyl alcohol first add in ginseng decoction liquor, add deer horn glue (making dissolve fully), and be concentrated into to the greatest extent
Relative density about 1.30 or so (60 DEG C).3. separately taking suitable Chinese cassia tree, steam distillation collects volatile oil, and beta cyclodextrin inclusion is dry
It is spare.4. above-mentioned thick paste, beta cyclodextrin clathrate are mixed, appropriate dextrin, stevioside are added in, is pelletized, dry, whole grain, packing,
To obtain the final product.
Embodiment 10：Tablet.
A kind of compound composite medicament for treating chronic aplastic anemia includes each component of following parts by weight：It is ripe
30 parts of glutinous rehmannia, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 30 parts of eclipta, Psoralen
15 parts of fat, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, Caulis Spatholobi
15 parts, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 30 parts of desmodium,
5 parts of tripterygium wilfordii, 3 parts of honey-fried licorice root.
In prescription ratio, more than Chinese medicine drink is weighed, is prepared by following techniques.1. people participates in 10 times of amount water extractions two in side
Secondary, filtration takes filtrate spare.2. in addition to deer horn glue, Chinese cassia tree, add 12 times of bulk pharmaceutical chemicals total weight to measure water, decoct extraction 3 times, often
Secondary 1 hour.Collecting decoction is concentrated into relative density 1.10 (60 DEG C survey), adds ethyl alcohol to alcohol content up to 60%, stand 12 hours with
On.Leaching supernatant, recycling ethyl alcohol first add in ginseng decoction liquor, add deer horn glue (making dissolve fully), and be concentrated into to the greatest extent
Relative density about 1.30 or so (60 DEG C).3. separately taking suitable Chinese cassia tree, steam distillation collects volatile oil, and beta cyclodextrin inclusion is dry
It is spare.4. above-mentioned thick paste, beta cyclodextrin clathrate are mixed, appropriate amount of starch is added in, is pelletized, dry, whole grain, tabletting, packing, i.e.,
.
Embodiment 11：Capsule.
A kind of compound composite medicament for treating chronic aplastic anemia includes each component of following parts by weight：It is ripe
15 parts of glutinous rehmannia, 15 parts of Chinese yam, 20 parts of Fructus Corni, 15 parts of Poria cocos, 15 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, 20 parts of eclipta, Psoralen
15 parts of fat, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, 10 parts of RADIX ANGELICAE SINEINSIS, Caulis Spatholobi
10 parts, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, 20 parts of desmodium,
5 parts of tripterygium wilfordii, 3 parts of honey-fried licorice root.
In prescription ratio, more than Chinese medicine drink is weighed, is prepared by following techniques.1. people participates in 12 times of amount water extractions two in side
Secondary, filtration takes filtrate spare.2. in addition to deer horn glue, Chinese cassia tree, add 10 times of bulk pharmaceutical chemicals total weight to measure water, decoct extraction 2 times, often
Secondary 1 hour.Collecting decoction is concentrated into relative density 1.10 (60 DEG C survey), adds ethyl alcohol to alcohol content up to 60%, stand 12 hours with
On.Leaching supernatant, recycling ethyl alcohol first add in ginseng decoction liquor, add deer horn glue (making dissolve fully), and be concentrated into to the greatest extent
Relative density about 1.30 or so (60 DEG C).3. separately taking suitable Chinese cassia tree, steam distillation collects volatile oil, and beta cyclodextrin inclusion is dry
It is spare.4. above-mentioned thick paste, beta cyclodextrin clathrate are mixed, add in appropriate amount of starch, pelletize, dry, whole grain, it is encapsulated to get.
Embodiment 12：
L clinical datas
1.1 diagnostic criteria：
Western medicine diagnostic criteria：With reference to the south opened《Diagnosis of hematological diseases and criterion of therapeutical effect》[3]：(1) clinical manifestation morbidity is more acute
Hinder again slowly, anaemia, infection, bleeding are relatively light；(2) blood picture hemoglobin decrease speed is slower, granulophilocyte, neutral grain
Cell and blood platelet lower, but the degree of acute aplastic anemia is not achieved；(3) tri- systems of bone marrow smear a. or two systems are reduced, at least one portion
Position hyperplasia is bad, and such as active proliferation, then lymphocyte is opposite increases, and megacaryocyte significantly reduces；B. non-hematopoiesis in marrow granule
Cell (such as adipocyte) significantly increases；(4) such as sb.'s illness took a turn for the worse in the course of disease, clinic, blood picture and bone marrow smear and acute aplastic anemia phase
Together, then referred to as II type of Severe aplastic anemia.
Tcm diagnosis standard：With reference to Zheng Xiao cornels《New Chinese medicine guideline of clinical investigations》[4]：(1) syndrome of deficiency of kidney yin：Main symptom：
Palpitaition, dizzy, the whole body is weak, and complexion lip nail is pale, night sweat, bleeding.Secondary card：Low-heat, feverishness in palms and soles is thirsty to think drink, greatly
Just dry and hard, tongue nature is light or red tip of tongue, and tongue is thin, thready rapid pulse.(2) syndrome of deficiency of kidney yang：Main symptom：Palpitaition, dizzy, weak, the complexion mouth in the whole body
Lip nail is pale, and shape limb of trembling with fear is cold, soreness and weakness of waist and knees.Secondary card：Hypogona dism, big loose stool is mostly slight without bleeding or bleeding, tongue nature
It is light, deep thready pulse or empty big.(3) syndrome of deficiency of both yin and yang of kidney：In addition to having deficiency of blood syndrome, kidney-yin deficiency and Kidney-Yang Deficiency Syndrome are had concurrently.
1.2 are included in and exclusion criteria：
Inclusion criteria：1. meet the domestic Western medicine diagnostic criteria of chronic aplastic anemia；2. it is ready to receive traditional Chinese medicine
Treatment；3. the age is in 14-85 one full year of life；
Exclusion criteria：1. gestation or women breast-feeding their children；2. to experimental drug allergy sufferers；3. merge serious and uppity
Infected patient；4. the patient of the major organs insufficiency such as the heart, liver, kidney；5. mental patient；6. participate in other clinical tests；
7. the patient of compliance difference.
General information：21 CAA are 2009-2013 to be hospitalized and the patient of outpatient clinic in Jiangsu TCM Hospital.Its
Middle male 12, female 9；Age 14-82 Sui (average age 56 ± 2 years old)；Course of disease 0.2-27 (average course of disease 6 ± 0.8 years)：
Hemoglobin (HGB) 26-102g/L；Leucocyte (WBC) (0.9-3.49) × 109/L；Blood platelet (PLT) (0-51) × 109/
L；Myelosis severe lowers 13, hypoplasia 8.Chinese medical discrimination kidney yang deficiency syndrome 6, kidney yin deficiency type 5, kidney insufficiency
10, type.Having 12 in 21 patients, the western medicines such as deactivated androgen, immunosuppressor at least three moon, 9 patients exist
Take androgen, during immunosuppressant treatment carries out subtracting after clinical judgment is invalid medicine for 6 months to 1 year.
2. method
2.1 therapy：All patients receive compound of Chinese herbal medicine, and prescription is as follows：30 grams of prepared rehmannia root, Chinese yam 30
Gram, 30 grams of Fructus Corni, 15 grams of Poria cocos, 10 grams of prepared fleece flower root, 15 grams of the fruit of glossy privet, 30 grams of eclipta, 15 grams of psoralea corylifolia, thizoma curculiginis 15
Gram, 15 grams of Herba Epimedii, 10 grams of deer horn glue, 10 grams of Herba Cistanches, 10 grams of dried human placenta, 10 grams of RADIX ANGELICAE SINEINSIS, 15 grams of Caulis Spatholobi, raw Radix Astragali 15
Gram, 5 grams of ginseng, 3 grams of cooked aconite, 3 grams of Chinese cassia tree, 15 grams of Glabrous Sarcandra Herb, 10 grams of selfheal, 30 grams of desmodium, 5 grams of tripterygium wilfordii, toast it is sweet
Careless 3-6 grams.Deficiency of vital energy severe one, Chinese yam, raw Radix Astragali can be used to 30 grams；Deficiency of blood severe one, Caulis Spatholobi add to 30 grams；Deficiency of Yin severe one, cultivated land
Huang, Fructus Corni, the fruit of glossy privet, eclipta can be used to 30 grams；Deficiency of yang severe one, Herba Cistanches add to 15 grams, and dried human placenta adds to 30 grams, ripe
Monkshood adds to 10 grams, and Chinese cassia tree is with to 5 grams；Heat toxin severe one, Glabrous Sarcandra Herb is with to 30 grams, and selfheal adds to 15 grams, and tripterygium wilfordii adds to 10
Gram, desmodium is then adjusted to 60 grams.Above-mentioned medicinal material is provided by Pharmacy of Jiangsu TCM Hospital, daily 1 dose, decocts 2 morning and evening sub-services,
Each 150ml.Supportive treatment of generally suiting the medicine to the illness routinely is given in therapeutic process, it is anti-infective if concurrent infection；Hemoglobin is low
In 50g/L person, it is transfused Red Blood Cells Concentrate as one sees fit；Hemorrhagic tendency is apparent, and platelet count is less than 20 × 109/ L person can take the circumstances into consideration to be transfused
Blood platelet.Hematopoietic cell growth factor preparation is not used in therapeutic process.
2.2 observation index and method
Further consultation is primary every 2 weeks in therapeutic process, and checks peripheral hemogram, fecaluria routine, hepatic and renal function, electrocardiogram, simultaneously
Collect TCM syndrome (primary symptom, minor symptom, tongue vein as etc.) variation.3 months 1 courses for the treatment of are treated the 2-3 course for the treatment of and are sentenced later into row index
It is disconnected：1. clinical disease curative effect；2. TCM syndrome curative effect；3. the horizontal variation of haemocyte before and after comparison therapy；4. observation treatment phase
Close adverse reaction.
2.3 criterion of therapeutical effect
Curative effect of disease criterion, reference《Diagnosis of hematological diseases and criterion of therapeutical effect》Related the effect of hindering again standard[5]：Substantially
It cures：Anaemia and bleeding disappear, and hemoglobin reaches 120g/L (man) or 110g/L (female), and leucocyte is up to 4.0 × 109/ L,
Blood platelet is up to 100 × 109/ L, follow-up 1 year or more are not recurred.Alleviate：Anaemia and bleeding disappear, and hemoglobin male reaches
120g/L, women reach 100g/L, and leucocyte is up to 3.5 × 109/ L or so, blood platelet also have and increase to a certain degree, 3 months diseases of follow-up
Feelings are stable or will continue to improve.Apparent progress：Anaemia and bleeding are clearly better, and do not transfuse blood, 1 before hemoglobin relatively treatment
Modal value increases more than 30g/L in month, and can maintain 3 months.Judge above 3 criterion of therapeutical effect persons, it should all be not defeated in 3 months
Blood.In vain：After fully treating, symptom, blood routine be not up to apparent progress.
Tcm syndrome curative effect determinate standard, reference《New Chinese medicine guideline of clinical investigations》In related therapeutic effect of syndrome sentence
Calibration is accurate[6]：Clinical recovery：Tcm clinical practice symptom, sign disappear or mostly disappear, syndrome integral reduce >=95%；It is effective：In
Doctor's clinical symptoms, sign are obviously improved, and syndrome integral reduces >=70%；Effectively：Tcm clinical practice symptom, sign take a favorable turn, card
It waits integration and reduces >=30%；In vain：Tcm clinical practice symptom, sign are not improved, even aggravating, syndrome integral reduces insufficient
30%.
2.4 statistical methods use 13.0 statistical softwares of SPSS.Measurement data is represented using " mean ± standard deviation ", is controlled
It treats front and rear relatively using student paired t test, P<0.05 is statistically significant for difference.
3. interpretation of result
3.1 clinical efficacy
It is basic to cure 3 (14.3%) in terms of Diseases of WM curative effect, alleviate 3 (14.3%), hence it is evident that progress 5
(23.8%).Invalid 10 (47.6%), total effective rate 52.4%.
3.2 TCM syndrome curative effects
In terms of TCM syndrome curative effect, be almost recovered 4 (19%), effective 6 (28.6%), effective 5 (23.8%),
Invalid 6 (28.6%), total effective rate is up to 71.4%.
3.3 peripheral hemogram
The three of 21 patients are that blood picture is increased significantly after treatment, and compared with before treatment, difference is statistically significant
(P<0.01).(table 1).
The pretherapy and post-treatment blood routine variation of 1 21 patients of table
Note：WBC:Leucocyte；Hb:Hemoglobin；PLT:Blood platelet.
3.4 adverse reaction
There is laxativeness or dry phenomenon, the dosage and ratio of adjusted relative medicine over the course for the treatment of in few patients
After reach equilibrium between yin and yang, related symptoms are alleviated then.Also the not found heart, Liver and kidney function patients with abnormal during follow-up.
Bibliography
[1] Zeng Qing, the journey latitude people ginseng cornel side of enriching blood are 3O [J] Guangxi traditional Chinese medicine of main treatment chronic aplastic anemia
Institute's journal, 2005,8 (1):18-19.
[2] Suhl cloud, Fang Yuhua, the invalid heavy regeneration of 62 immunosuppressive therapies of Chen Hui tree therapies of combing traditional Chinese and Western medicine
Aplastic anemia clinical observation [J] China combination of Chinese tradiational and Western medicine magazine, 2012,32 (12):1616-1620.
[3] south opened, Shen are loved and respect one's elder brother the 3rd edition Beijing of diagnosis of hematological diseases and criterion of therapeutical effect [M]:Science Press, 2007:19-
20.
[4] Zheng Xiao cornels new Chinese medicines guideline of clinical investigations [M] Beijing：China Medical Science Press, 2002:
178.
[5] south opened, Shen are loved and respect one's elder brother the 3rd edition Beijing of diagnosis of hematological diseases and criterion of therapeutical effect [M]：Science Press, 2007:21-
23.
[6] Zheng Xiao cornels new Chinese medicines guideline of clinical investigations [M] Beijing：China Medical Science Press, 2002:
180.
[7] the positive treatment of chronic aplastic anemia of Li Haixia, Qu Yongkang, Sun Wei should be " using kidney as this, kidney treating therapy "
[J] traditional Chinese medicine journals, 2005,33 (1):21-22.
[8] Wang Yan, An Yuji, Cui Xing wait chronic aplastic anemia kidney treating therapy progress [J] Liaoning traditional Chinese medical science
Institute's journal, 2006,8 (3):45-46.
[9] Zhou Aixiang, village outstanding person's shield, Deng Chengshan wait cuscuta japonica Choisies drink poor for the chronic aplastic of main traditional tonic medicine treatment
The clinical observation and experimental study [J] Chinese Journal of Hematologies that blood 169 falls, 1986,8 (7):492.
[10] Wang Shuqing, Li Jianhua, Zhang Shengming wait Bushen Huayu Recipes to Bone Marrow of The Patients With Aplastic Anemia DNA's
Influence [J] China combination of Chinese tradiational and Western medicine magazine, 1996,16 (7)：411-412.
[11] Gai Yun, Gao Ruilan, ox is vast flat, and notoginseng total saponins is waited to make immune mediating Induced Aplastic Anemia Mice
Proliferation function [J] the China combination of Chinese tradiational and Western medicine magazine of blood progenitor cell, 2003,23 (9):680-683.
[12] Shu Yanjun, Chinese-English, the Liu Wenli of profit, waits compounds blood activating decoction to immune induction Induced Aplastic Anemia Mice bone
Effect study [J] the China combination of Chinese tradiational and Western medicine magazine of marrow microenvironment, 1998,18 (6)：359-360.
[13] crown army, Gao Suojun, Yi Yonglin wait the facilitation China combination of Chinese tradiational and Western medicine of the heat-clearing and detoxifying drugs to hematopoiesis
Magazine, fundamental research spy collection in 1993：110-112.
[14] progress [J] traditional Chinese medicine Leaders of Zhang Jianliang heat-clearing and detoxifying herbs immunoregulation effect, 2012,12
(18)： 87-89.
Claims (8)
1. a kind of Chinese medicine composition for treating chronic aplastic anemia, which is characterized in that it by following parts by weight group
Divide and be made：30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, eclipta
30 parts, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, RADIX ANGELICAE SINEINSIS 10
Part, 15 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, money
30 parts of grass, 5 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
2. a kind of Chinese medicine composition for treating chronic aplastic anemia, which is characterized in that it by following parts by weight group
Divide and be made：30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, eclipta
30 parts, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, RADIX ANGELICAE SINEINSIS 10
Part, 15 parts of Caulis Spatholobi, raw 30 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, money
30 parts of grass, 5 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
3. a kind of Chinese medicine composition for treating chronic aplastic anemia, which is characterized in that it by following parts by weight group
Divide and be made：30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, eclipta
30 parts, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, RADIX ANGELICAE SINEINSIS 10
Part, 30 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, money
30 parts of grass, 5 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
4. a kind of Chinese medicine composition for treating chronic aplastic anemia, which is characterized in that it by following parts by weight group
Divide and be made：30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 30 parts of the fruit of glossy privet, eclipta
30 parts, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, RADIX ANGELICAE SINEINSIS 10
Part, 15 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, money
30 parts of grass, 5 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
5. a kind of Chinese medicine composition for treating chronic aplastic anemia, which is characterized in that it by following parts by weight group
Divide and be made：30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, eclipta
30 parts, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 15 parts of Herba Cistanches, 30 parts of dried human placenta, RADIX ANGELICAE SINEINSIS 10
Part, 15 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali, 5 parts of ginseng, 10 parts of cooked aconite, 5 parts of Chinese cassia tree, 15 parts of Glabrous Sarcandra Herb, 10 parts of selfheal, gold
30 parts of money grass, 5 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
6. a kind of Chinese medicine composition for treating chronic aplastic anemia, which is characterized in that it by following parts by weight group
Divide and be made：30 parts of prepared rehmannia root, 30 parts of Chinese yam, 30 parts of Fructus Corni, 15 parts of Poria cocos, 10 parts of prepared fleece flower root, 15 parts of the fruit of glossy privet, eclipta
30 parts, 15 parts of psoralea corylifolia, 15 parts of thizoma curculiginis, 15 parts of Herba Epimedii, 10 parts of deer horn glue, 10 parts of Herba Cistanches, 10 parts of dried human placenta, RADIX ANGELICAE SINEINSIS 10
Part, 15 parts of Caulis Spatholobi, raw 15 parts of Radix Astragali, 5 parts of ginseng, 3 parts of cooked aconite, 3 parts of Chinese cassia tree, 30 parts of Glabrous Sarcandra Herb, 15 parts of selfheal, money
60 parts of grass, 10 parts of tripterygium wilfordii, 3-6 parts of honey-fried licorice root.
7. the Chinese medicine composition of the treatment chronic aplastic anemia in claim 1 ~ 6 described in any one is preparing treatment
Application in chronic aplastic anemia disease drug.
8. application according to claim 7, which is characterized in that the drug, dosage form is decoction, tablet, granule
Or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510313857.3A CN104940516B (en) | 2015-06-09 | 2015-06-09 | A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510313857.3A CN104940516B (en) | 2015-06-09 | 2015-06-09 | A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104940516A CN104940516A (en) | 2015-09-30 |
| CN104940516B true CN104940516B (en) | 2018-06-19 |
Family
ID=54155941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510313857.3A Active CN104940516B (en) | 2015-06-09 | 2015-06-09 | A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104940516B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343518B (en) * | 2015-11-23 | 2019-08-27 | 丽水市人民医院 | A kind of Chinese medicine preparation and preparation method thereof for treating chronic aplastic anemia |
| CN107198715A (en) * | 2016-03-18 | 2017-09-26 | 兰州大学 | A kind of pharmaceutical composition and its application in anti-infectives are prepared |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279013A (en) * | 2008-05-04 | 2008-10-08 | 北京中科仁和科技有限公司 | Chinese medicine compound for curing chronic type aplastic anemia |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130036800A (en) * | 2011-10-05 | 2013-04-15 | 경희대학교 산학협력단 | A composition for stimulating immune response comprising an extract of angelicae gigantis radix and astragali radix |
-
2015
- 2015-06-09 CN CN201510313857.3A patent/CN104940516B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279013A (en) * | 2008-05-04 | 2008-10-08 | 北京中科仁和科技有限公司 | Chinese medicine compound for curing chronic type aplastic anemia |
Non-Patent Citations (1)
| Title |
|---|
| 益肾生血方联合西药治疗慢性再生障碍性贫血40例;方炳木等;《中国中医药科技》;20130930;第20卷(第5期);第548-549页，尤其是第548页右栏2治疗方法 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104940516A (en) | 2015-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1742939B (en) | Medicine for treating pulmonary fibrosis and preparing method | |
| CN102772748B (en) | Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof | |
| CN102526326B (en) | Traditional Chinese medicine for treating postmenopausal osteoporosis and preparation method thereof | |
| CN102793884A (en) | Chinese medical plaster for treating dysmenorrhea and preparation method thereof | |
| CN103316205A (en) | Traditional Chinese medicine for treating iron-deficiency anemia and preparation method thereof | |
| CN105125851A (en) | Traditional Chinese medicine treating 2-type diabetes and preparation technology | |
| CN101670011A (en) | Medicament for treating rheumatism and rheumatoid and preparation method thereof | |
| CN104940516B (en) | A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application | |
| CN113134057A (en) | Compound traditional Chinese medicine preparation for treating hyperlipemia and preparation method thereof | |
| CN101940674A (en) | Chinese medicament for treating diabetic peripheral neuropathy | |
| CN103463409A (en) | Traditional Chinese medicine formula for treating heart qi deficiency | |
| CN102631518B (en) | New medicament for treating leukemia | |
| CN102319338B (en) | Chinese medicinal medicament for treating myelodysplastic syndrome (MDS) by mainly using natural indigo and realgar and preparation method of Chinese medicinal preparation | |
| CN104623314A (en) | Medicine composition for treating dry mouth and bitter taste and preparation method thereof | |
| CN104605051B (en) | Double numb tea containing leaves of Eucommia ulmoides and preparation method | |
| CN103463244A (en) | Method for extracting blood sugar lowering substance from China roses and application of blood sugar lowering substance | |
| CN101658567A (en) | Medicament for treating coronary heart disease and angina and preparation method of granular formulation thereof | |
| CN101972367A (en) | Traditional Chinese medicine for treating diabetic peripheral neuropathy | |
| CN102552677B (en) | Coptis chinensis and radix rehmanniae Anxiao capsule and preparation method thereof | |
| CN1318066C (en) | Medicine for treating dysmenorrhes and preparation thereof | |
| CN100509019C (en) | Application of Baji capsule in preparing immune enhancement medicament | |
| CN108743885A (en) | A kind of Chinese medicine and preparation method thereof for treating Diabetic Macrovascular Complications | |
| CN102727806B (en) | Traditional Chinese medicine for treating aplastic anemia by tonifying qi | |
| CN107753638B (en) | Medicine for promoting bone marrow hematopoiesis and preparation method and application thereof | |
| CN101979050A (en) | Traditional Chinese medicine for treating diabetic peripheral neuropathy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |