CN101279013A - Chinese medicine compound for curing chronic type aplastic anemia - Google Patents
Chinese medicine compound for curing chronic type aplastic anemia Download PDFInfo
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- CN101279013A CN101279013A CNA2008101058413A CN200810105841A CN101279013A CN 101279013 A CN101279013 A CN 101279013A CN A2008101058413 A CNA2008101058413 A CN A2008101058413A CN 200810105841 A CN200810105841 A CN 200810105841A CN 101279013 A CN101279013 A CN 101279013A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic aplastic anemia. The effective components of the invention are extracted from more than ten medicine materials such as cuscuth japonica, psoralea corylifolia, radix astragali, Chinese angelica, boschiniakia glabra, morinda officinalis, curculigo ensifolia, colla corii asini, gold theragran, dogwood, ecipta alba, epimedium macranthum, Chinese cynomorium, prepared rehmannia root, fruit of the Chinese wolfberry. The special active components of the medicine of the invention have the effects of invigorating the kidney and nourishing the blood and have good efficacy on the chronic aplastic anemia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of Chinese medicine composition for the treatment of chronic aplastic anemia.
Technical background
It is the hematopoietic disorders that Different types of etiopathogenises causes that aplastic anemia (aplastic anemia) is called for short aplastic anemia, causes the red bone marrow total capacity to reduce, and generation, hemopoietic depletion was one group of syndrome of main performance with the pancytopenia with fatty marrow.According to the municipal investigation of domestic 21 provinces (city), annual morbidity is 0.74/10 ten thousand populations, is starkly lower than leukemic sickness rate; The chronic aplastic anemia sickness rate is 0.60/10 ten thousand populations, and acute aplastic anemia is 0.14/10 ten thousand populations; Each age group all can be fallen ill, but sees with person between twenty and fifty more; Male's sickness rate is a little more than the women.Generally show as anemia, hemorrhage, infect, heating (hyperpyrexia or low grade fever), and with weak on foot, symptoms such as dizziness.
Aplastic anemia is divided congenital and acquired two big classes, and is most with acquired residence.Congenital aplastic anemia is very rare, and its main type is the Fanconi anemia.Acquired aplastic anemia can divide former and Secondary cases amphitypy, and the former is agnogenio person, accounts for 50% of acquired aplastic anemia; Can be divided into acute and chronic amphitypy by the different comprehensive classifications of clinical manifestation, hemogram and bone marrow smear again; Mark off serious type aplastic anemia by severity abroad, latter's criteria for classifying palpus hemogram possesses the binomial in following three: 1. neutrophilic granulocyte absolute value＜500/mm 3,2. platelet count＜20,000/mm 3,3. reticulocyte (packed cell volume correction value)＜1%; The medullary cell hyperplasia degree is subnormal 25%, as＜50%, and hematopoietic cell＜30% then.Wherein neutrophilic granulocyte absolute value＜200/mm claims extremely heavy aplastic anemia.The type aplastic anemia I type of in the 4th national aplastic anemia academic conference in 1987 acute aplastic anemia being weighed, the chronic aplastic anemia deuterogenesis sudden turn of events person type aplastic anemia II type of weighing.
(1) acute aplastic anemia: onset is anxious, and progress often reaches main performance with hemorrhage and infectious fever for first rapidly.Sick just anemia is often not obvious, but along with course of disease development, is carrying out property progress.Bleeding tendency is almost all arranged, visceral hemorrhage is arranged more than 60%, mainly show as digestive tract hemorrhage, hematuria, retinal hemorrhage (often with visual disorder) and intracranial hemorrhage.Skin, mucosal bleeding are extensively and serious, and is and wayward.Heating is almost all arranged in the course of disease, is due to the infection, the ulcer that necroses around be everlasting pars oralis pharyngis and the anus, thus cause septicemia.Pneumonia is also very common.Infect and hemorrhage reciprocal causation, the state of an illness is gone from bad to worse, dead in 1 year as only adopting the general treatment majority.
(2) chronic type aplastic anemia: onset is slow, is first and mainly shows with minute blood; Hemorrhage be limited to mucocutaneous, and not serious; But accompanying infection, but often based on respiratory tract, control easily.If treatment is proper, and is unremitting, many patients can obtain long-term remission so that recovery from illness, but also have part patient delay not heal for many years, even course of disease decades-long, and minority the clinical manifestation of acute aplastic anemia occurs to the later stage, is called chronic aplastic anemia sudden turn of events type.
The present invention is the crystallization of traditional traditional Chinese medical science and modern science and technology.Be on the basis of traditional traditional Chinese medical science to the understanding of aplastic anemia and treatment, to the pathogenesis of aplastic anemia and the analysis and the understanding of pathogenesis, and the pharmacological action of the uniqueness that Chinese medicine had is developed in conjunction with modern medicine.Clinical practice shows that the present invention has enriching yin and nourishing kidney, the effect of benefiting QI and nourishing blood.
Summary of the invention:
One of purpose of the present invention provides a kind of Chinese medicine composition for the treatment of chronic aplastic anemia.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1, prescription:
Semen Cuscutae 100-200 part Fructus Psoraleae 100-200 part Radix Astragali 100-200 part
Radix Angelicae Sinensis 100-200 part Herba Cistanches 100-200 part Radix Morindae Officinalis 100-200 part
Rhizoma Curculiginis 100-200 part Colla Corii Asini 100-200 part Radix Polygoni Multiflori 100-200 part
Fructus Corni 100-200 part Herba Ecliptae 100-200 part Herba Epimedii 100-200 part
Herba Cynomorii 100-200 part Radix Rehmanniae Preparata 100-200 part Radix Polygoni Multiflori 100-200 part
Fructus Lycii 100-200 part
The active component that preferred following raw materials according is made, curative effect is better:
200 parts of 150 parts of Radixs Astragali of 150 parts of Fructus Psoraleaes of Semen Cuscutae
100 parts of 150 parts of Radix Morindae Officinaliss of 200 parts of Herba Cistanches of Radix Angelicae Sinensis
150 parts of 150 parts of Radixs Polygoni Multiflori of 150 parts of Colla Corii Asini of Rhizoma Curculiginis
100 parts of 100 parts of Herba Epimedii of 150 portions of Herba Ecliptaes of Fructus Corni
150 parts of 200 parts of Radixs Polygoni Multiflori of 100 parts of Radix Rehmanniaes Preparata of Herba Cynomorii
100 parts of Fructus Lycii
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2, preparation technology:
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Semen Cuscutae, Fructus Psoraleae, Herba Cistanches, Radix Morindae Officinalis, Rhizoma Curculiginis, the Radix Polygoni Multiflori, Fructus Corni, Herba Ecliptae, Herba Epimedii, Herba Cynomorii, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, Fructus Lycii add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has enriching yin and nourishing kidney, and the effect of benefiting QI and nourishing blood has the good curing effect for chronic aplastic anemia.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
200 parts of 150 parts of Radixs Astragali of 150 parts of Fructus Psoraleaes of Semen Cuscutae
100 parts of 150 parts of Radix Morindae Officinaliss of 200 parts of Herba Cistanches of Radix Angelicae Sinensis
150 parts of 150 parts of Radixs Polygoni Multiflori of 150 parts of Colla Corii Asini of Rhizoma Curculiginis
100 parts of 100 parts of Herba Epimedii of 150 portions of Herba Ecliptaes of Fructus Corni
150 parts of 200 parts of Radixs Polygoni Multiflori of 100 parts of Radix Rehmanniaes Preparata of Herba Cynomorii
100 parts of Fructus Lycii
2. preparation technology
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Semen Cuscutae, Fructus Psoraleae, Herba Cistanches, Radix Morindae Officinalis, Rhizoma Curculiginis, the Radix Polygoni Multiflori, Fructus Corni, Herba Ecliptae, Herba Epimedii, Herba Cynomorii, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, Fructus Lycii add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
200 parts of 150 parts of Radixs Astragali of 150 parts of Fructus Psoraleaes of Semen Cuscutae
100 parts of 150 parts of Radix Morindae Officinaliss of 200 parts of Herba Cistanches of Radix Angelicae Sinensis
150 parts of 150 parts of Radixs Polygoni Multiflori of 150 parts of Colla Corii Asini of Rhizoma Curculiginis
100 parts of 100 parts of Herba Epimedii of 150 portions of Herba Ecliptaes of Fructus Corni
150 parts of 200 parts of Radixs Polygoni Multiflori of 100 parts of Radix Rehmanniaes Preparata of Herba Cynomorii
100 parts of Fructus Lycii
2. preparation technology
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Semen Cuscutae, Fructus Psoraleae, Herba Cistanches, Radix Morindae Officinalis, Rhizoma Curculiginis, the Radix Polygoni Multiflori, Fructus Corni, Herba Ecliptae, Herba Epimedii, Herba Cynomorii, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, Fructus Lycii add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
200 parts of 150 parts of Radixs Astragali of 150 parts of Fructus Psoraleaes of Semen Cuscutae
100 parts of 150 parts of Radix Morindae Officinaliss of 200 parts of Herba Cistanches of Radix Angelicae Sinensis
150 parts of 150 parts of Radixs Polygoni Multiflori of 150 parts of Colla Corii Asini of Rhizoma Curculiginis
100 parts of 100 parts of Herba Epimedii of 150 portions of Herba Ecliptaes of Fructus Corni
150 parts of 200 parts of Radixs Polygoni Multiflori of 100 parts of Radix Rehmanniaes Preparata of Herba Cynomorii
100 parts of Fructus Lycii
2. preparation technology
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Semen Cuscutae, Fructus Psoraleae, Herba Cistanches, Radix Morindae Officinalis, Rhizoma Curculiginis, the Radix Polygoni Multiflori, Fructus Corni, Herba Ecliptae, Herba Epimedii, Herba Cynomorii, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, Fructus Lycii add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of Chinese medicine composition for the treatment of chronic aplastic anemia is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Semen Cuscutae 100-200 part Fructus Psoraleae 100-200 part Radix Astragali 100-200 part
Radix Angelicae Sinensis 100-200 part Herba Cistanches 100-200 part Radix Morindae Officinalis 100-200 part
Rhizoma Curculiginis 100-200 part Colla Corii Asini 100-200 part Radix Polygoni Multiflori 100-200 part
Fructus Corni 100-200 part Herba Ecliptae 100-200 part Herba Epimedii 100-200 part
Herba Cynomorii 100-200 part Radix Rehmanniae Preparata 100-200 part Radix Polygoni Multiflori 100-200 part
Fructus Lycii 100-200 part.
2, a kind of Chinese medicine composition for the treatment of chronic aplastic anemia according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
200 parts of 150 parts of Radixs Astragali of 150 parts of Fructus Psoraleaes of Semen Cuscutae
100 parts of 150 parts of Radix Morindae Officinaliss of 200 parts of Herba Cistanches of Radix Angelicae Sinensis
150 parts of 150 parts of Radixs Polygoni Multiflori of 150 parts of Colla Corii Asini of Rhizoma Curculiginis
100 parts of 100 parts of Herba Epimedii of 150 portions of Herba Ecliptaes of Fructus Corni
150 parts of 200 parts of Radixs Polygoni Multiflori of 100 parts of Radix Rehmanniaes Preparata of Herba Cynomorii
100 parts of Fructus Lycii.
3, according to the described a kind of Chinese medicine composition for the treatment of chronic aplastic anemia of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Semen Cuscutae, Fructus Psoraleae, Herba Cistanches, Radix Morindae Officinalis, Rhizoma Curculiginis, the Radix Polygoni Multiflori, Fructus Corni, Herba Ecliptae, Herba Epimedii, Herba Cynomorii, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, Fructus Lycii add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of Chinese medicine composition for the treatment of chronic aplastic anemia among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of Chinese medicine composition for the treatment of chronic aplastic anemia of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| CNA2008101058413A CN101279013A (en) | 2008-05-04 | 2008-05-04 | Chinese medicine compound for curing chronic type aplastic anemia |
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| CNA2008101058413A CN101279013A (en) | 2008-05-04 | 2008-05-04 | Chinese medicine compound for curing chronic type aplastic anemia |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758485A (en) * | 2015-04-01 | 2015-07-08 | 青岛云天生物技术有限公司 | Traditional Chinese medicine composition for treating aplastic anemia and preparation method of traditional Chinese medicine composition |
| CN104940516A (en) * | 2015-06-09 | 2015-09-30 | 江苏省中医院 | Traditional Chinese medicine composition for treating chronic aplastic anemia, and preparation method and application thereof |
| CN105343518A (en) * | 2015-11-23 | 2016-02-24 | 刘永华 | Traditional Chinese medicine formula for treating chronic aplastic anemia and preparation method thereof |
| CN108671076A (en) * | 2018-07-31 | 2018-10-19 | 李少伦 | A kind of drug and preparation method thereof for treating alpastic anemia |
| CN111686201A (en) * | 2020-07-28 | 2020-09-22 | 广西中医药大学第一附属医院 | Semen cuscutae paste and preparation method and application thereof |
-
2008
- 2008-05-04 CN CNA2008101058413A patent/CN101279013A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758485A (en) * | 2015-04-01 | 2015-07-08 | 青岛云天生物技术有限公司 | Traditional Chinese medicine composition for treating aplastic anemia and preparation method of traditional Chinese medicine composition |
| CN104940516A (en) * | 2015-06-09 | 2015-09-30 | 江苏省中医院 | Traditional Chinese medicine composition for treating chronic aplastic anemia, and preparation method and application thereof |
| CN104940516B (en) * | 2015-06-09 | 2018-06-19 | 江苏省中医院 | A kind of Chinese medicine composition for treating chronic aplastic anemia and preparation method and application |
| CN105343518A (en) * | 2015-11-23 | 2016-02-24 | 刘永华 | Traditional Chinese medicine formula for treating chronic aplastic anemia and preparation method thereof |
| CN105343518B (en) * | 2015-11-23 | 2019-08-27 | 丽水市人民医院 | A kind of Chinese medicine preparation and preparation method thereof for treating chronic aplastic anemia |
| CN108671076A (en) * | 2018-07-31 | 2018-10-19 | 李少伦 | A kind of drug and preparation method thereof for treating alpastic anemia |
| CN111686201A (en) * | 2020-07-28 | 2020-09-22 | 广西中医药大学第一附属医院 | Semen cuscutae paste and preparation method and application thereof |
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Open date: 20081008 |