CN111686201A - Semen cuscutae paste and preparation method and application thereof - Google Patents
Semen cuscutae paste and preparation method and application thereof Download PDFInfo
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- CN111686201A CN111686201A CN202010739571.2A CN202010739571A CN111686201A CN 111686201 A CN111686201 A CN 111686201A CN 202010739571 A CN202010739571 A CN 202010739571A CN 111686201 A CN111686201 A CN 111686201A
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract
The invention discloses a semen cuscutae paste and a preparation method and application thereof. The dodder paste is prepared from the following raw materials in parts by weight: 25-35 parts of semen cuscutae, 10-20 parts of cistanche, 10-20 parts of wolfberry fruit, 15-25 parts of prepared rhizome of rehmannia, 10-20 parts of glossy privet fruit, 10-20 parts of morinda officinalis, 10-20 parts of mulberry fruit, 10-20 parts of fructus psoraleae, 10-20 parts of fleece-flower root, 5-15 parts of dogwood, 10-20 parts of rhizoma polygonati and 2-12 parts of medicated leaven. The invention is suitable for patients with kidney essence deficiency and kidney qi deficiency, and the selected raw material medicines have complementary medicine properties, so that the medicines have obvious mutual reinforcement and mutual effect; meanwhile, the prepared clear paste saves the time for decocting medicinal materials for patients, avoids the condition of unstable curative effect of the medicaments caused by improper decoction, is easy to store and carry, and improves the medical compliance of the patients.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to semen cuscutae paste and a preparation method and application thereof.
Background
Semen Cuscutae decoction is prepared by Song, Taiping Huimin He Ji Ju Fang, and can be used for treating deficiency of spirit and qi, five kinds of work and seven kinds of injuries, blurred vision, tinnitus, palpitation, short breath, etc., and is clinically used for patients with kidney qi deficiency, such as female with dark skin color after menopause, fatigue and asthenia after radiotherapy and chemotherapy, or blood system diseases such as aplastic anemia and thrombocytopenic purpura, etc. The kidney-qi deficiency refers to the weak condition of kidney-qi deficiency manifested as soreness and weakness of the waist and knees, urination, seminal fluid, amenorrhea, and unconsolidation of fetal qi. At present, most of the medicines for treating the disease are decoction, the medicine taking time is different from one week to one month, but the problems of long decoction time, unchanged carrying and the like often cause poor medical compliance of patients, and the curative effect is influenced because the patients cannot insist on taking the medicines.
Disclosure of Invention
The technical problem to be solved by the invention is to provide the dodder paste which can avoid the trouble of decocting traditional Chinese medicines and ensure the curative effect for patients, and the preparation method and the application of the dodder paste.
In order to solve the technical problems, the invention adopts the following technical scheme:
firstly, the invention provides a dodder paste which is prepared from the following raw materials in parts by weight: 25-35 parts of semen cuscutae, 10-20 parts of cistanche, 10-20 parts of wolfberry fruit, 15-25 parts of prepared rhizome of rehmannia, 10-20 parts of glossy privet fruit, 10-20 parts of morinda officinalis, 10-20 parts of mulberry fruit, 10-20 parts of fructus psoraleae, 10-20 parts of fleece-flower root, 5-15 parts of dogwood, 10-20 parts of rhizoma polygonati and 2-12 parts of medicated leaven.
The preferable parts by weight of the raw materials are as follows: 28-33 parts of semen cuscutae, 13-18 parts of cistanche, 13-18 parts of wolfberry fruit, 18-23 parts of prepared rhizome of rehmannia, 13-18 parts of glossy privet fruit, 13-18 parts of morinda officinalis, 13-18 parts of mulberry fruit, 13-18 parts of fructus psoraleae, 13-18 parts of fleece-flower root, 8-13 parts of dogwood, 13-18 parts of rhizoma polygonati and 4-9 parts of medicated leaven.
The optimal weight parts of the raw materials are as follows: 30 parts of semen cuscutae, 15 parts of cistanche, 15 parts of wolfberry fruit, 20 parts of prepared rhizome of rehmannia, 15 parts of glossy privet fruit, 15 parts of morinda officinalis, 15 parts of mulberry fruit, 15 parts of fructus psoraleae, 15 parts of fleece-flower root, 10 parts of dogwood, 15 parts of rhizoma polygonati and 6 parts of medicated leaven.
The raw materials of the invention have the following effects:
semen Cuscutae, a seed of Cuscuta chinensis or Cuscuta chinensis of Convolvulaceae, has effects of nourishing liver and kidney, consolidating semen, and reducing urination.
Cistanche deserticola, succulent stem of cistanche deserticola of Orobanchaceae, has the effects of invigorating kidney yang and benefiting essence and blood.
Fructus Lycii is mature fruit of Solanaceae plant fructus Lycii or Ningxia fructus Lycii, and has effects of nourishing liver and kidney, replenishing vital essence and improving eyesight.
Radix rehmanniae Preparata is prepared from rhizome of Scrophulariaceae plant rehmanniae radix or HUAIQINGDIHUANG by steaming and sun drying, and has effects of replenishing blood, moistening, replenishing vital essence, and replenishing marrow.
Fructus Ligustri Lucidi, fruit of Ligustrum lucidum belonging to Oleaceae, has effects in nourishing liver and kidney, and strengthening waist and knee.
Morinda officinalis is the root of Morinda officinalis of Rubiaceae, and has effects of invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, invigorating kidney yang, and strengthening tendons and bones.
Mulberry fruit, the fruit ear of Moraceae plant Mulberry, has the efficacy of nourishing yin and blood.
Fructus Psoraleae is fruit of Psoralea corylifolia of Leguminosae, and has effects of warming kidney, tonifying yang, and promoting inspiration.
Polygoni Multiflori radix, a plant of Polygonaceae, has effects of nourishing liver and kidney, and replenishing essence and blood.
Corni fructus, pulp of Corni fructus of Cornaceae, has effects of nourishing liver and kidney, and arresting seminal emission.
Rhizoma Polygonati is rhizome of Liliaceae plant rhizoma Polygonati, rhizoma Polygonati Sibirici, rhizoma Polygonati Yunnanensis, and rhizoma Polygonati Odorati, and has effects of invigorating qi, nourishing yin, and invigorating kidney.
Medicated leaven is prepared by mixing herba Polygoni Hydropiperis, herba Artemisiae Annuae, and semen Armeniacae amarum, adding flour or testa Tritici, and fermenting to obtain leaven, and has effects of invigorating spleen, regulating stomach function, and resolving food stagnation.
Secondly, the invention also provides a preparation method of the dodder paste, which comprises the following steps:
1) soaking semen cuscutae, herba cistanches, fructus lycii, radix rehmanniae preparata, fructus ligustri lucidi, radix morindae officinalis, mulberries, fructus psoraleae, polygonum multiflorum, dogwood, rhizoma polygonati and medicated leaven in water for 0.4-0.6 hour, decocting twice, and combining the obtained liquid medicines;
2) filtering and concentrating the liquid medicine obtained in the step 1), adding auxiliary materials, stirring, and decocting to obtain paste to obtain the semen cuscutae paste.
In the step 1), water is added for the first time to soak the medicine surface for 10-20 cm, and the medicine is boiled and decocted for 0.8-1.2 hours; and adding water to soak the medicine powder for 3-7 cm for the second time, and decocting for 0.4-0.6 hour after boiling.
Finally, the invention also provides application of the dodder seed paste in preparing a medicine for treating kidney essence deficiency and kidney qi deficiency. It is suitable for patients with kidney essence deficiency and kidney qi deficiency, with symptoms of aversion to cold, sallow or pale complexion, dark spot on face, pale lips and teeth, no blood color, sunken eye pit, dizziness, tinnitus, soreness of waist and knees, leg and foot debilitation, and inability to concentrate attention.
And the application of the dodder seed paste in preparing the medicine for treating the lung containing the hemosiderosis.
And the application of the dodder paste in preparing the medicine for treating aplastic anemia.
And the application of the dodder paste in preparing the medicine for treating thrombocytopenic purpura.
The dodder paste is derived from the dodder drinking formula from Song, Taiping Huimin He Ji Ju Fang, and is a further improvement and modification of the formula. Semen Cuscutae can tonify kidney essence, strengthen waist and knee joint; the medlar, the glossy privet fruit and the mulberry fruit nourish kidney yin; the prepared rhizome of rehmannia is blood-fleshed, has the effect of replenishing vital essence and replenishing marrow; the morinda officinalis, the fructus psoraleae and the cistanche are matched to warm kidney yang, so that yin and yang are mutually transformed, essence is filled without being greasy, and yang is warmed without being dry; and Polygoni Multiflori radix for strengthening tendons and bones, nourishing liver and kidney, Corni fructus for nourishing liver and kidney, and Massa Medicata Fermentata for invigorating qi and nourishing yin, and invigorating spleen and regulating stomach can be used for treating deficiency of spirit and qi, five strains and seven impairments, blurred vision, tinnitus, palpitation, short breath, etc. The selected raw material medicaments are complementary in medicinal properties, so that the medicaments complement each other and have obvious mutual action; meanwhile, the prepared clear paste saves the time for decocting medicinal materials for patients, avoids the condition of unstable curative effect of the medicaments caused by improper decoction, is easy to store and carry, and improves the medical compliance of the patients.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
Example 1
The dodder paste is prepared from the following raw materials in parts by weight: 30g of semen cuscutae, 15g of cistanche, 15g of wolfberry fruit, 20g of prepared rhizome of rehmannia, 15g of glossy privet fruit, 15g of morinda officinalis, 15g of mulberry fruit, 15g of fructus psoraleae, 15g of fleece-flower root, 10g of dogwood, 15g of rhizoma polygonati and 6g of medicated leaven.
The preparation method of the dodder paste comprises the following steps:
1) soaking semen Cuscutae, Cistanchis herba, fructus Lycii, radix rehmanniae Preparata, fructus Ligustri Lucidi, radix Morindae officinalis, Mori fructus, fructus Psoraleae, Polygoni Multiflori radix, Corni fructus, rhizoma Polygonati, and Massa Medicata Fermentata in water for 15cm above the surface of the materials, soaking for 0.5 hr, boiling, decocting for 1 hr, and filtering to obtain filtrate. And decocting for the second time, adding water to the second time until the water level reaches 5cm, boiling, decocting for 0.5 hr, and mixing the obtained medicinal liquid with the medicinal liquid obtained from the previous time.
2) Filtering with multiple layers of clean gauze, concentrating the liquid medicine obtained in step 1), adding adjuvants such as walnut and maltose, stirring continuously, and decocting to obtain tablet (flag hanging) or dripping bead shape to obtain paste. And finally, filling, labeling and storing at 2-8 ℃.
Example 2
The dodder paste is prepared from the following raw materials in parts by weight: 25g of semen cuscutae, 20g of cistanche, 10g of wolfberry fruit, 25g of prepared rhizome of rehmannia, 10g of glossy privet fruit, 20g of morinda officinalis, 10g of mulberry fruit, 20g of fructus psoraleae, 10g of fleece-flower root, 15g of dogwood, 10g of rhizoma polygonati and 12g of medicated leaven.
The preparation of example 2 is similar to example 1.
Example 3
The dodder paste is prepared from the following raw materials in parts by weight: 35g of semen cuscutae, 10g of cistanche, 20g of wolfberry fruit, 15g of prepared rhizome of rehmannia, 20g of glossy privet fruit, 10g of morinda officinalis, 20g of mulberry fruit, 10g of fructus psoraleae, 20g of fleece-flower root, 5g of dogwood fruit, 20g of rhizoma polygonati and 2g of medicated leaven.
The preparation of example 3 is similar to example 1.
The efficacy of the invention is demonstrated in clinical applications, typical cases are as follows:
case 1
Li Jie, male, 6 years old, first visit 2015, 6 months and 18 days.
The main complaints are: sallow complexion for more than 3 years
The current medical history: the patient has no obvious inducement to sallow complexion, fever and headache before complaint for 3 years, is diagnosed as 'lung ferrihemoxanthin deposition disease' after relevant examination, and the complaint symptom is improved to be discharged after treatment (unrefined medication). The patients continue to see the doctor for further treatment, and the symptoms are as follows: sallow complexion, general debilitation, no headache, no fever, easy fatigue and insomnia, convenient adjustment, pale tongue with thin coating and thready pulse.
Paving and assisting in inspection: blood routine shows that: RBC3.61 × 10-12/L, HGB91.9g/L.
And (3) Western diagnosis: the lung contains hemosiderosis.
Traditional Chinese medicine diagnosis: consumptive disease (kidney essence deficiency).
Because of the inconvenience of decoction, the dodder seed paste is taken by patients every day. 7 months and 16 days. Parents complain about the improvement of the above symptoms, and the blood routine is rechecked in 18 days at 6 months: 3.51 × 110-12/L erythrocytes and 87g/L hemoglobin. Convenient adjustment, insomnia, pale tongue with thin coating and thready pulse. After the administration is continued for one year, the hemoglobin of the patient returns to normal.
Case 2
Liangjia, woman, age 13. First diagnosis in 2017, 8 months and 10 days.
The main complaints are: general fatigue and weakness for 2 years
The current medical history: patients have no obvious reason before complaints for 2 years, and have general fatigue and weakness, and have been diagnosed in hospitals, and have been diagnosed with aplastic anemia and megakaryocyte hyperplasia, and take 50mg of hormone (unrefined) per tablet for 6g per day, and the skin on the face has black spots, so that people can not sleep well and have good appetite and convenient regulation. The tongue has white blood-streaked coating and weak pulse.
Auxiliary inspection: 1. blood routine shows that: platelets: 20 × 10-9/L; 2. bone marrow biopsy: aplastic anemia.
And (3) Western diagnosis: aplastic anemia.
Traditional Chinese medicine diagnosis: blood syndrome (kidney essence deficiency).
Because of the inconvenience of decoction, the dodder seed paste is taken by patients every day. After one year of administration, the blood of the patient returns to normal routinely.
Claims (10)
1. The dodder paste is characterized by being prepared from the following raw materials in parts by weight: 25-35 parts of semen cuscutae, 10-20 parts of cistanche, 10-20 parts of wolfberry fruit, 15-25 parts of prepared rhizome of rehmannia, 10-20 parts of glossy privet fruit, 10-20 parts of morinda officinalis, 10-20 parts of mulberry fruit, 10-20 parts of fructus psoraleae, 10-20 parts of fleece-flower root, 5-15 parts of dogwood, 10-20 parts of rhizoma polygonati and 2-12 parts of medicated leaven.
2. The dodder paste as claimed in claim 1, wherein the raw materials in parts by weight are as follows: 28-33 parts of semen cuscutae, 13-18 parts of cistanche, 13-18 parts of wolfberry fruit, 18-23 parts of prepared rhizome of rehmannia, 13-18 parts of glossy privet fruit, 13-18 parts of morinda officinalis, 13-18 parts of mulberry fruit, 13-18 parts of fructus psoraleae, 13-18 parts of fleece-flower root, 8-13 parts of dogwood, 13-18 parts of rhizoma polygonati and 4-9 parts of medicated leaven.
3. The dodder paste as claimed in claim 2, wherein the raw materials in parts by weight are as follows: 30 parts of semen cuscutae, 15 parts of cistanche, 15 parts of wolfberry fruit, 20 parts of prepared rhizome of rehmannia, 15 parts of glossy privet fruit, 15 parts of morinda officinalis, 15 parts of mulberry fruit, 15 parts of fructus psoraleae, 15 parts of fleece-flower root, 10 parts of dogwood, 15 parts of rhizoma polygonati and 6 parts of medicated leaven.
4. The preparation method of semen cuscutae paste as claimed in any one of claims 1 to 3, characterized by comprising the steps of:
1) soaking semen cuscutae, herba cistanches, fructus lycii, radix rehmanniae preparata, fructus ligustri lucidi, radix morindae officinalis, mulberries, fructus psoraleae, polygonum multiflorum, dogwood, rhizoma polygonati and medicated leaven in water for 0.4-0.6 hour, decocting twice, and combining the obtained liquid medicines;
2) filtering and concentrating the liquid medicine obtained in the step 1), adding auxiliary materials, stirring, and decocting to obtain paste to obtain the semen cuscutae paste.
5. The method of claim 4, wherein: in the step 1), water is added for the first time to soak the medicine surface for 10-20 cm, and the medicine is boiled and decocted for 0.8-1.2 hours; and adding water to soak the medicine powder for 3-7 cm for the second time, and decocting for 0.4-0.6 hour after boiling.
6. The method of claim 4, wherein: the auxiliary materials in the step 2) are walnut and maltose.
7. The use of dodder paste of any one of claims 1 to 6 in the preparation of a medicament for the treatment of kidney essence deficiency and kidney qi deficiency.
8. Use of the dodder paste of any one of claims 1 to 6 in the manufacture of a medicament for the treatment of hemosiderosis in the lung.
9. Use of semen Cuscutae paste as claimed in any one of claims 1 to 6 in the preparation of a medicament for treating aplastic anemia.
10. Use of the dodder paste of any one of claims 1 to 6 in the preparation of a medicament for the treatment of thrombocytopenic purpura.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101279013A (en) * | 2008-05-04 | 2008-10-08 | 北京中科仁和科技有限公司 | Chinese medicine compound for curing chronic type aplastic anemia |
Non-Patent Citations (2)
| Title |
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| 林武红，等: "黄贵华对血液病的中医治疗思路总结", 《湖南中医杂志》 * |
| 陈奇: "《中成药名方药理与临床》", 31 March 1998, 人民卫生出版社 * |
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Application publication date: 20200922 |