CN106581299B - Traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and old people and application thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and old people and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of codonopsis pilosula, 15-25 parts of radix astragali preparata, 12-18 parts of angelica, 15-25 parts of fructus psoraleae, 15-25 parts of pyrola, 10-20 parts of wolfberry fruit and 10-20 parts of red paeony root. Clinical tests show that the traditional Chinese medicine composition can obviously improve the symptoms and the life quality of middle-aged and elderly patients with kidney qi deficiency, so that the traditional Chinese medicine composition can be used for preparing medicines for treating the kidney qi deficiency and delaying senility, and has the advantages of few medicinal components, convenience in preparation and low cost.

Description

A traditional Chinese medicine composition for improving kidney-qi deficiency syndrome in middle-aged and elderly people and its application

technical field

The present invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicinal composition for improving kidney-qi deficiency syndrome of middle-aged and elderly people and its application.

Background technique

At present, with the development of society, we are gradually entering an aging society. How to delay the aging process and improve the quality of life of middle-aged and elderly people is receiving more and more attention. The understanding of human aging or premature aging in traditional Chinese medicine has a long history and is extremely rich in content, which is recognized by most scholars. And those who have better actual effects should take the theory that kidney deficiency causes failure as the most important. The kidney stores the essence, which is the foundation of the innate and the source of life. The kidney is the master to preside over and maintain all the physiological functions of the human body, so that it can be unified and balanced, and can self-regulate and stabilize normal activities, thereby resisting diseases. Deficiency of kidney qi results in a lack of biochemical sources of qi, blood and body fluids in the five internal organs, and various aging diseases are increasingly exposed. Chinese medicine also believes that there is no chronic disease or chronic disease that does not damage the kidney qi, so there is a saying that "diseases that have been ill for a long time and poverty will affect the kidneys". If the kidney qi is damaged, symptoms of kidney qi deficiency such as soreness of the waist and weak knees, fatigue and fatigue are common.

At present, there are many traditional Chinese medicine prescriptions for kidney-qi deficiency syndrome in traditional Chinese medicine treatment. For example, Chinese patent document CN200510075262.5, published on 2006.12.13, discloses a pharmaceutical composition for treating kidney-qi deficiency syndrome and a quality control method thereof. The pharmaceutical composition is prepared from the following raw materials: Cnidium 20- 40 parts by weight, 20-40 parts by weight of Chuanxiong, 50-80 parts by weight of Dodder, 20-40 parts by weight of Bakuchi, 20-40 parts by weight of Poria, 15-25 parts by weight of red ginseng, 10-20 parts by weight of cumin, 30-40 parts by weight of Schisandra, 60-120 parts by weight of Jinyingzi, 10-20 parts by weight of Atractylodes, 40-60 parts by weight of Angelica sinensis, 25-40 parts by weight of raspberries, 60-90 parts by weight of Polygonum multiflorum, 10 parts by weight of psyllium -20 parts by weight, 60-120 parts by weight of Rehmannia glutinosa, 50-80 parts by weight of Lycium barbarum, 40-60 parts by weight of Chinese yam, 60-120 parts by weight of Epimedium, 60-120 parts by weight of Fenugreek, 40-60 parts by weight of Astragalus Parts by weight, 40-60 parts by weight of Cistanche deserticola, 10-20 parts by weight of Zhigancao, the pharmaceutical composition and its granules have the functions of reconciling yin and yang, warming yang and tonifying the kidney, soothing the nerves and strengthening the essence, strengthening the body and strengthening the body, and are clinically used for impotence, Nocturnal emission, soreness in waist and legs, lack of energy, frequent urination at night, chills and chills, menorrhagia in women, and thin leucorrhea. For another example, the Qilu Jianshen Granule disclosed by the applicant in the paper "Qilu Jianshen Granule Improves the Clinical Observation of Kidney Qi Deficiency Syndrome in Middle-aged and Elderly" published in the Chinese journal "Liaoning Journal of Traditional Chinese Medicine" in 2012, Vol. 39, No. 7, is formulated with Ginseng, Qi, Zhu Yiqi and spleen; Gui, peony to nourish blood and nourish the heart and liver; Tsubaki, Psoralea, Lu Hancao, Lycium barbarum and Yigui tonic together, strengthen tendons and bones. This recipe is the patent applicant's homemade preparation in the hospital. It was founded in the 1980s. It is composed of the crystallization of the wisdom of many famous and old Chinese medicine practitioners, and has achieved good clinical effects.

However, the theory of traditional Chinese medicine is broad and profound, there are many ways of compatibility of traditional Chinese medicine prescriptions, and the compatibility relationship between medicinal materials is even more subtle. Therefore, Chinese medicine scholars will have their own unique experience of prescriptions and improve them. Based on the profound theoretical basis of traditional Chinese medicine and his own understanding of the compatibility of prescriptions, the inventor of the present application has made further improvements on the basis of the original Qilu Jianshen Granules, in order to improve the therapeutic effect of the prescription.

SUMMARY OF THE INVENTION

The purpose of the present invention is to aim at the deficiencies in the prior art, and to provide a traditional Chinese medicine composition for improving middle-aged and elderly people with kidney-qi deficiency syndrome.

Another object of the present invention is to provide the use of the Chinese medicine composition.

Another object of the present invention is to provide a preparation method of the traditional Chinese medicine composition granules.

For realizing above-mentioned first purpose, the technical scheme that the present invention takes is:

A traditional Chinese medicine composition for improving kidney-qi deficiency syndrome in middle-aged and elderly people, which is prepared from the following raw materials by weight: 15-25 parts of Codonopsis Radix, 15-25 parts of Zhi Huangqi, 12-18 parts of Angelica sinensis, 15-25 parts of Psoraleae 15-25 parts of deer containing grass, 10-20 parts of wolfberry fruit, 10-20 parts of red peony.

Preferably, it is made from the following raw materials by weight: 18-22 parts of Codonopsis Radix, 18-22 parts of Sunburn Astragalus, 15-18 parts of Angelica sinensis, 18-22 parts of Psoraleae, 18-22 parts of Deer Radix, 14-18 parts of wolfberry and 14-18 parts of red peony.

More preferably, it is made of the following raw materials by weight: 20 parts of Codonopsis pilosula, 20 parts of Sunburn Astragalus, 16.67 parts of Angelica sinensis, 20 parts of psoralen, 20 parts of Deer Radix, 15 parts of wolfberry fruit, 15 parts of red peony root .

As a specific embodiment of the present invention, the dosage form of the traditional Chinese medicine composition is granule, capsule, tablet or mixture.

For realizing the above-mentioned second purpose, the technical scheme that the present invention takes is:

Application of any one of the above-mentioned traditional Chinese medicine compositions in the preparation of medicines for improving kidney-qi deficiency syndrome in middle-aged and elderly people.

Application of any one of the above-mentioned traditional Chinese medicine compositions in the preparation of anti-aging medicines.

For realizing the above-mentioned third purpose, the technical scheme that the present invention takes is:

The preparation method of the granules of the traditional Chinese medicine composition as described in any one of the above, comprising the following steps: weighing each raw material, adding 6-10 times and 2-6 times of water respectively and decocting twice, after each boiling Incubate at 80-90°C for 10-30 minutes, filter the decoction, combine the filtrates and concentrate to a relative density of more than 1.0, leave it for more than 10 hours, take the supernatant and add it to a conventional pharmaceutical carrier, mix well, dry, and pulverize into fine powder , add an appropriate amount of ethanol to granulate, and dry to obtain the final product.

In this article, the roasted Astragalus is the processed product of Astragalus, and the preparation method is as follows: take astragalus slices, stir-fry them according to the method of honey roasting until they are not sticky; Dried whole grass of Pyrola calliantha H.Andres.

The advantages of the present invention are:

1, Chinese medicinal composition prescription of the present invention selects lycium barbarum, deer containing grass as the king, and wolfberry fruit is sweet and flat in nature, and returns to the two meridians of liver and kidney, and its function is to invigorate kidney yin; Gong can invigorate the kidneys, help the yang, strengthen the muscles and bones; the two are combined as a king drug, tonic for the liver and kidney, yi and gui tonic, nourishing the yin and warming the yang. Select Psoralea as the minister. Psoralea is hard-working and warm in nature. It belongs to the two meridians of the spleen and kidney. Its functions can invigorate the kidney, help the yang and strengthen the waist. The group formula is supplemented with Codonopsis, Astragalus, Angelica. Codonopsis is sweet and flat in nature, and belongs to the spleen and lung meridians. Its functions can invigorate the middle and invigorate the qi, and the stomach and produce body fluid. The effect of Wei Gubiao; Angelica is sweet and pungent in nature, warm in nature, returns to the liver, heart and spleen meridians, and has the effect of invigorating blood and activating blood; these three herbs, in addition to assisting the monarch and minister medicine, can also invigorate qi, generate body fluid, nourish blood and activate blood, tonic without stagnation, qi and blood Co-adjustment makes Qi and blood biochemically active, and blood stasis cannot remain. In addition, there is red peony root in the prescription, which is bitter in taste and slightly cold in nature. It belongs to the liver and spleen meridians. In addition to its effect of promoting blood circulation and dissipating blood stasis, it is also used for its slightly cold nature. trouble. Although the name of this prescription is for strengthening the kidney, it is actually a supplement for the five viscera, qi, blood, yin and yang because the kidney is the foundation of the five zang organs and the most important point of nourishment. Clinical experiments show that compared with the original Qilu Jianshen prescription, the traditional Chinese medicine composition of the present invention can improve the symptoms and quality of life of middle-aged and elderly patients with kidney-qi deficiency syndrome more significantly, and the compatibility is more precise, and it has great advantages in the treatment of clinically related diseases. potential.

2. The traditional Chinese medicine composition of the present invention has less medicinal taste, is more convenient to prepare, and has low cost.

Detailed ways

The specific embodiments provided by the present invention will be described in detail below.

The preparation of embodiment 1 Chinese medicine composition mixture of the present invention (1)

15 parts of Codonopsis Radix, 25 parts of Astragalus root, 12 parts of Angelica sinensis, 25 parts of Psoralea, 15 parts of Luhancao, 20 parts of Lycium barbarum, 10 parts of red peony, decocted by conventional method.

The preparation of embodiment 2 Chinese medicine composition mixture of the present invention (two)

25 parts of Codonopsis Radix, 15 parts of Sunburn Astragalus, 18 parts of Angelica sinensis, 15 parts of Psoralea, 25 parts of Luhancao, 10 parts of Lycium barbarum, 20 parts of red peony root, decocted by conventional method.

The preparation of embodiment 3 Chinese medicine composition mixture of the present invention (three)

15 parts of Codonopsis, 15 parts of Astragalus root, 18 parts of Angelica sinensis, 25 parts of Psoralea, 15 parts of Luhancao, 10 parts of Lycium barbarum, 20 parts of red peony, decocted by conventional method.

The preparation of embodiment 4 Chinese medicine composition mixture of the present invention (four)

25 parts of Codonopsis pilosula, 25 parts of roasted astragalus, 12 parts of Angelica sinensis, 15 parts of psoralen, 25 parts of Luhancao, 20 parts of wolfberry fruit, 10 parts of red peony root, decocted by conventional method.

The preparation of embodiment 5 Chinese medicine composition mixture of the present invention (5)

15 parts of Codonopsis Radix, 15 parts of Sunburn Astragalus, 12 parts of Angelica sinensis, 15 parts of Psoralea, 25 parts of Luhancao, 20 parts of Lycium barbarum, 20 parts of red peony root, decocted by conventional method.

The preparation of embodiment 6 Chinese medicine composition mixture of the present invention (six)

25 parts of Codonopsis, 25 parts of Astragalus root, 18 parts of Angelica sinensis, 15 parts of Psoralea, 15 parts of Luhancao, 10 parts of Lycium barbarum, 10 parts of red peony, and boiled by conventional method.

The preparation of embodiment 7 traditional Chinese medicine composition mixture of the present invention (seven)

18 parts of Codonopsis Radix, 22 parts of Sunburn Astragalus, 15 parts of Angelica sinensis, 22 parts of Psoralea, 18 parts of Luhancao, 18 parts of Lycium barbarum, 14 parts of Red Peony, decocted by conventional method.

The preparation of embodiment 8 traditional Chinese medicine composition mixture of the present invention (eight)

22 parts of Codonopsis, 18 parts of Astragalus root, 18 parts of Angelica sinensis, 18 parts of Psoralea, 22 parts of Luhancao, 14 parts of Lycium barbarum, 18 parts of red peony root, decocted by conventional method.

The preparation of embodiment 9 Chinese medicine composition mixture of the present invention (nine)

18 parts of Codonopsis Radix, 18 parts of Sunburn Astragalus, 18 parts of Angelica sinensis, 22 parts of psoralen, 18 parts of Luhancao, 14 parts of wolfberry fruit, 18 parts of red peony root, decocted by conventional method.

Embodiment 10 Preparation of Chinese medicine composition mixture of the present invention (ten)

22 parts of Codonopsis Radix, 22 parts of Sunburn Astragalus, 18 parts of Angelica sinensis, 18 parts of Psoralea, 18 parts of Luhancao, 14 parts of Lycium barbarum, 18 parts of red peony root, decocted by conventional method.

Embodiment 11 Preparation of Chinese medicine composition mixture of the present invention (Eleven)

20 parts of Codonopsis, 20 parts of Astragalus root, 16.67 parts of Angelica sinensis, 20 parts of Psoralea, 20 parts of Luhancao, 15 parts of Lycium barbarum, 15 parts of Chishao, decocted by conventional method.

Example 12 Preparation of Chinese medicine composition granules of the present invention

Weigh each raw material according to the proportion by weight described in any one of Examples 1-11, add 8 times of water and 4 times of water and decocted for two times respectively, and keep the temperature at 85°C for 20 minutes after each boil. Filter, combine the filtrates and concentrate to a relative density of more than 1.0, leave it for more than 10 hours, take the supernatant, add an appropriate amount of dextrin and steviol, mix well, dry, pulverize into fine powder, add an appropriate amount of ethanol to granulate, and dry to obtain .

Example 13 Preparation of Chinese medicine composition capsules of the present invention

Weigh each raw material according to the proportion by weight described in any one of Examples 1-11, add 8 times of water and 4 times of water and decocted for two times respectively, and keep the temperature at 85°C for 20 minutes after each boil. Filter, combine the filtrates and concentrate to a relative density of more than 1.0, leave for more than 10 hours, take the supernatant, add an appropriate amount of dextrin and steviol, mix well, dry, pulverize into fine powder, add an appropriate amount of ethanol to granulate, dry, pulverize, Filled capsules.

Example 14 Preparation of Chinese medicine composition tablet of the present invention

Weigh each raw material according to the proportion by weight described in any one of Examples 1-11, add 8 times of water and 4 times of water and decocted for two times respectively, and keep the temperature at 85°C for 20 minutes after each boil. Filter, combine the filtrates and concentrate to a relative density of more than 1.0, leave for more than 10 hours, take the supernatant, add an appropriate amount of dextrin and steviol, mix well, dry, pulverize into fine powder, add an appropriate amount of ethanol to granulate, dry, pulverize, Compressed into tablets.

Example 15 Clinical trial

1 Materials and methods

1.1 General information

A total of 160 patients in the outpatient and inpatient wards of the geriatric department of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine from January 2013 to August 2014 were collected and divided into two groups according to the random table method. There were 80 patients in the treatment group, including 57 males and 23 females; the age ranged from 46 to 88 years, with an average age of (65.88±6.27) years; the average weight was (62.90±10.05) kg. The control group consisted of 80 patients, 52 males and 28 females; the age ranged from 47 to 90 years, with an average age of (64.08±8.73) years; the average weight was (61.41±7.99) kg. There was no significant difference in age, weight and gender between the two groups (P>0.05), and they were comparable. Follow the principle of voluntary and informed consent.

1.2 Case selection

1.2.1 Inclusion criteria

Refer to the "Traditional Chinese Medicine Disease Diagnosis and Treatment Standards" promulgated by the State Administration of Traditional Chinese Medicine in 1994. (1) Age > 45 years; (2) Meet the diagnostic criteria of kidney-qi deficiency syndrome: have 2 main symptoms of kidney-qi deficiency syndrome; or 1 main symptom plus 2 secondary symptoms.

Diagnostic criteria for TCM syndromes: Main symptoms: lumbar pain, fatigue, or edema, anorexia or abdominal distention; secondary symptoms: loose stools, frequent urination or nocturia, pale red tongue, tooth marks, thin white coating, Thin pulse.

1.2.2 Exclusion criteria

(1) Those who do not meet the inclusion criteria; (2) Those who do not belong to the scope of action; (3) Those who have obvious concurrent or combined syndromes; Drugs that strengthen tendons and bones, calm and nourish; (5) The patient has participated in other clinical trials within 3 months; (6) Women who are breastfeeding pregnant or preparing to become pregnant; (7) Allergic constitutions and those allergic to multiple drugs (8) Suspect or have a history of drug abuse, or, according to the judgment of the investigator, have other diseases or conditions that reduce the possibility of enrollment or complicate enrollment, such as frequent changes in the working environment and other conditions that are likely to cause loss to follow-up; (9) Patients with serious primary diseases such as liver, kidney, hematopoietic system, endocrine system, and mental illness; (10) Critical illness (such as severe cardiac insufficiency, severe infection and tumor, etc.), it is difficult to determine the effectiveness and safety of drugs Sexuality makes an accurate assessment.

1.3 Treatment methods

The treatment group was given the granules of the traditional Chinese medicine composition of the present invention, and the preparation method was as follows: Weigh 200 g of Codonopsis Radix, 200 g of Astragalus root, 166.7 g of Angelica sinensis, 200 g of psoralen, 200 g of Luhancao, 150 g of wolfberry fruit, and 150 g of red peony root, add 8 times The amount and 4 times the amount of water were decocted twice, after each boiling, the temperature was kept at 85 ° C for 20 minutes, the decoction was filtered, the filtrate was combined and concentrated to a relative density of 1.5, placed for 12 hours, and the supernatant was added. Add an appropriate amount of dextrin , Steviolin 4.2g, mix well, dry, pulverize into fine powder, add appropriate amount of ethanol to granulate, dry to make 1000g, 12g per bag.

The control group was given Qilu Jianshen granules, and the preparation method was as follows: Weigh 200 g of Codonopsis Radix, 200 g of Astragalus root, 166.7 g of Angelica sinensis, 200 g of Danggui, 200 g of psoralen, 200 g of Luhancao, 150 g of Lycium barbarum, 150 g of Atractylodes Rhizoma, 150 g of Paeonia lactiflora , respectively add 8 times and 4 times the amount of water to decoct twice, after each boil, keep the temperature at 85 ° C for 20 minutes, filter the decoction, combine the filtrate and concentrate it to a relative density of 1.5, leave it for 12 hours, take the supernatant Add an appropriate amount of dextrin and 4.2g of steviol into the liquid, mix well, dry, pulverize into fine powder, add an appropriate amount of ethanol to granulate, and dry to make 1000g, 12g per bag.

The above medicines are taken with boiled water, 12g each time, 2 times a day. The dose cannot be changed during this period. The first day after qualifying enrollment was taken as the first day of study medication. A total of 6 weeks of treatment.

1.4 Observation items

(1) Safety indicators: general items such as heart rate, respiration, blood pressure; routine examination of blood, urine and stool; liver and kidney function; electrocardiogram. (2) Efficacy evaluation: Symptom score: The main symptoms include lumbar pain, cold pain in the lumbar spine, fatigue, edema, lack of gas and lazy speech, chills, cold limbs, dizziness, tinnitus, etc. No or disappearance of symptoms was scored as 0; mild symptoms or occasional symptoms were scored as 1; moderate symptoms were scored as 2 scores when mild and severe; 3 scores were scored as obvious symptoms.

Quality of life score (refer to the paper "Qilu Jianshen Granule Improves Kidney-Qi Deficiency Syndrome in Middle-aged and Elderly" published in "Liaoning Journal of Traditional Chinese Medicine", Vol. 39, No. 7, 2012): mainly include appetite, sleep, general activity, mental state, mood , relationship with people, interest in life, etc. The score is scored as 0 points for very good, and 10 points for extremely poor, which are selected between 0 and 10 respectively.

Evaluation standard: case score=sum of each symptom score. Clinical recovery: TCM clinical symptoms and signs disappeared or basically disappeared, and the syndrome score decreased by ≥95%. Significantly effective: TCM clinical symptoms and signs were significantly improved, and the syndrome score was reduced by ≥70%. Effective: TCM clinical symptoms and signs have improved, and syndrome scores have been reduced by ≥30%. Invalid: TCM clinical symptoms and signs were not significantly improved, or even worsened, and the syndrome score was reduced by <30%.

Note: Calculation formula (Nimodipine method)=(Total score before treatment-Total score after treatment)/Total score before treatment×100%.

1.5 Statistical processing

表示，计量资料用t检验及方差分析，计数资料用χ²检验作统计学处理。The data were analyzed using SPSS 18.0 software.

The measurement data were analyzed by t test and variance analysis, and the count data were analyzed by χ ² test.

2 Results and Analysis

After the test, a total of 5 cases dropped out, with a drop-out rate of 3.13%, including 1 case in the treatment group and 4 cases in the control group. The trial finally included 155 cases, 79 cases in the treatment group and 76 cases in the control group.

2.1 Comparison of symptoms and curative effects between the two groups

After treatment, the symptoms of lumbar spine pain, lumbar spine cold pain, fatigue, edema, lack of breath and lazy speech, chills, dizziness, tinnitus and other symptoms were significantly improved in the two groups of patients. The statistical results of the total effective rate are shown in Table 1. Compared with the control group, the total effective rate of the treatment group was significantly different (P<0.01).

Table 1 Comparison of the symptoms and curative effects of the two groups

group Number of cases (cases) Clinical recovery (case) Effective (example) Valid (example) invalid (example) total efficiency therapy group 79 18 33 twenty two 6 92.41%*** control group 76 6 17 34 19 75.00%

Note: Compared with the control group, **P<0.01.

2.2 Comparison of quality of life between the two groups

After treatment, the appetite, sleep, general activities, mental state, mood, interpersonal communication and interest in life of the two groups of patients were significantly improved. The statistical results of the improvement rate of quality of life are shown in Table 2. Compared with the control group, the improvement rate of quality of life in the treatment group was statistically significant (P<0.01) in appetite, mental state and mood, and in sleep, general activities and interest in life (P<0.01). 0.05), there was no statistically significant difference in interacting with people (P>0.05), which may be related to the influence of personal personality, living environment and many other factors in the relationship with people in addition to physical health.

Table 2 Comparison of quality of life improvement rates

Project/Group therapy group control group appetite 0.84±0.33 0.55±0.20** sleep 0.76±0.32 0.58±0.31* general activities 0.72±0.40 0.57±0.29* mental state 0.85±0.36 0.64±0.30** mood 0.77±0.42 0.52±0.27** interact with people 0.69±0.39 0.59±0.34 life interest 0.71±0.28 0.56±0.24*

Note: Compared with the control group, *P<0.05, **P<0.01.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the method of the present invention, several improvements and supplements can be made, and these improvements and supplements should also be regarded as It is the protection scope of the present invention.

Claims (7)

1. A traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and elderly people is characterized by being prepared from the following raw material medicines in parts by weight: 15-25 parts of codonopsis pilosula, 15-25 parts of radix astragali preparata, 12-18 parts of angelica, 15-25 parts of fructus psoraleae, 15-25 parts of pyrola, 10-20 parts of wolfberry fruit and 10-20 parts of red paeony root; the preparation method of the traditional Chinese medicine composition comprises the following steps: weighing the raw materials, adding 6-10 times and 2-6 times of water respectively, decocting twice, keeping the temperature at 80-90 ℃ for 10-30 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a conventional medicinal carrier, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, and drying to obtain the traditional Chinese medicine composition.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw material medicines in parts by weight: 18-22 parts of codonopsis pilosula, 18-22 parts of radix astragali preparata, 15-18 parts of angelica, 18-22 parts of fructus psoraleae, 18-22 parts of pyrola, 14-18 parts of wolfberry fruit and 14-18 parts of red paeony root.

3. The traditional Chinese medicine composition according to claim 2, which is prepared from the following raw material medicines in parts by weight: 20 parts of codonopsis pilosula, 20 parts of radix astragali preparata, 16.67 parts of angelica, 20 parts of fructus psoraleae, 20 parts of herba pyrolae, 15 parts of wolfberry fruit and 15 parts of red paeony root.

4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the Chinese medicinal composition is in the form of granules, capsules or tablets.

5. The use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of a medicament for improving kidney qi deficiency in the middle-aged and elderly.

6. Use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of an anti-aging medicament.

7. A method for preparing granules of the Chinese medicinal composition according to any one of claims 1 to 3, which comprises the following steps: weighing the raw materials, adding 6-10 times and 2-6 times of water respectively, decocting twice, keeping the temperature at 80-90 ℃ for 10-30 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a conventional medicinal carrier, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, and drying to obtain the traditional Chinese medicine composition.