CN108653373A - A kind of ginseng Tu parasitism cream of external application and preparation method thereof - Google Patents

A kind of ginseng Tu parasitism cream of external application and preparation method thereof Download PDF

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CN108653373A
CN108653373A CN201810674411.7A CN201810674411A CN108653373A CN 108653373 A CN108653373 A CN 108653373A CN 201810674411 A CN201810674411 A CN 201810674411A CN 108653373 A CN108653373 A CN 108653373A
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parts
ginseng
parasitism
cream
chinese medicine
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沈坚华
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Guangzhou Liwan District Tcm Hospital
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Guangzhou Liwan District Tcm Hospital
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
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    • A61K36/06—Fungi, e.g. yeasts
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract

The invention discloses ginseng Tu parasitism cream of a kind of external application and preparation method thereof, and ginseng Tu parasitism cream is made by Chinese medicine and auxiliary material；The Chinese medicine is made of the raw material of following parts by weight：28 parts of Semen Cuscutae, 4 12 parts of Ramulus Taxilli, 3 10 parts of teasel root, 1 part of folium artemisiae argyi, 15 parts of Cortex Eucommiae, 4 12 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 28 parts of Poria cocos.Ginseng Tu parasitisms patch will be made after the tabletting of ginseng Tu parasitism cream, lid lining, slice.The ginseng Tu parasitism cream of the present invention is clinical experience side for many years, has effects that tocolysis is rushed in kidney tonifying admittedly, curative for effect for speen-kidney dificiency, the threatened abortion of the debility of chong and ren channels and fetal irritability.The effect of to further increase this prescription, ensures the quality of the pharmaceutical preparations, facilitates patient to carry and solve traditional Chinese medicine and decocts loaded down with trivial details defect, the present invention is further developed as ointment patch, is convenient for carrying and is used.

Description

A kind of ginseng Tu parasitism cream of external application and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of ginseng Tu parasitism cream of external application and preparation method thereof.
Background technology
Miscarriage is one of gynemetrics's common disease, is mainly shown as colporrhagia with abdominal pain, pregnant thing discharge when serious and it is pregnant It is pregnent termination.Miscarriage also has the possibility that repeated, and leads to recurrent miscarriage (Chinese medicine claims " habitual abortion "), is injured to patient's physical and mental health It is larger.Before threatened abortion refers to 28 weeks pregnant, there is a small amount of colporrhagia and/or hypogastralgia, opening of the cervix is not opened, and fetal membrane is not broken, Product of conception is not yet discharged, and gestation is not still hopeful person.Threatened abortion belongs to " threatened abortion, fetal irritability ", " pregnant abdomen described in Chinese medicine The scopes such as bitterly ".If it is timely to diagnose correct treatment, prognosis bona.
Currently, optional tocolysis class drug of preventing miscarriage is more in the market.Wherein, prevent miscarriage Chinese medicine due to its Small side effects and by More and more favors.
The tocolysis of Chinese medicine is treated, and generally based on dialectical traditional Chinese medicine for oral administration or Chinese patent drug, but is sent out in clinical and experimental study It is existing, there are liver metabolisms to influence for peroral dosage form, dietary factor influences etc..Due to hormonal effects, gastrointestinal function reduces gravid woman, Absorb poor, the bioavilability reduction of drug.And the general mouthfeel of traditional Chinese medicine for oral administration is poor, gravid woman is difficult due to physiological reaction In adhering to taking orally.
104623502 A of Chinese patent application CN disclose a kind of Chinese medicine composition for tocolysis, and formula contains 20 Kinds of traditional Chinese medicines, range is very big, and the efficacy of a drug not enough essence is specially.And " there's no such thing as a totally safe medicine ", Chinese medicine are free from side effects also and non-fully, flavour of a drug Too many side effect can also increase therewith.
External application antiabortive medicine will not aggravate the physiological reaction of gestation, avoid the dry of liver and gastrointestinal tract " first pass effect " It disturbs, is a kind of alternative preferably for oral administration.In externally applied drug object space face, there are body surface smearing, point-application, stifling, sachet etc. more Kind form of medication.
Chinese patent application CN 103845537A disclose a kind of miscarriage prevention health sachet, which contains prepared fleece flower root, sea The kinds of traditional Chinese medicines such as wind rattan, Herba Cistanches, Semen Cuscutae, raspberry, eclipta, radix boehmeriae, Rhizoma Atractylodis Macrocephalae, safflower, Radix Paeoniae Alba.The formula is almost Ingredient without containing strengthening the spleen and replenishing qi Gu Chong, and caulis piperis futokadsurae therein plays the role of degrading the channel, safflower play the role of it is promoting blood circulation and removing blood stasis, Both drugs can be used for pregnant and folder hemostasis orThe patient of lump in the abdomen, but be not suitable for general tocolysis patient, in medicine Safflower is even had an abortion in allusion quotation.
Chinese patent application CN 106075090A disclose a kind of Chinese medicine tocolysis emulsifiable paste, the emulsifiable paste by Herba Cistanches, Radix Paeoniae Alba, The kinds of traditional Chinese medicines such as Radix Glycyrrhizae, the fruit of Chinese wolfberry, Semen Cuscutae, Cortex Eucommiae, radix rehmanniae preparata, caulis perllae, pedicellus cucurbitae, radix boehmeriae, lotus seeds, dendrobium candidum are made. The dynamics of this part of patent strengthening the spleen and replenishing qi Gu Chong is insufficient, and adds the drug of a variety of clearing heat and nourishing yin, such as the stem of noble dendrobium, pedicellus cucurbitae, ramie Root is suitable for gestation and folder yin defiency patient, restricted application.
Invention content
In order to overcome the defect of existing class tocolysis Chinese medicine for oral administration, the primary purpose of the present invention is that providing a kind of ginseng of external application Tu parasitism cream.
Another object of the present invention is to provide the production methods of above-mentioned ginseng Tu parasitism cream.
It is still another object of the present invention to provide join Tu parasitisms patch made from above-mentioned ginseng Tu parasitism cream.
The purpose of the invention is achieved by the following technical solution：
One seed ginseng Tu parasitism cream, is made by Chinese medicine and auxiliary material；
The Chinese medicine is made of the raw material of following parts by weight：
Semen Cuscutae：2-8 parts
Ramulus Taxilli：4-12 parts
Teasel root：3-10 parts
Folium artemisiae argyi：1 part
Cortex Eucommiae：1-5 parts
Radix Codonopsis：4-12 parts
Rhizoma Atractylodis Macrocephalae：1-5 parts
Poria cocos：2-8 parts；
The formula of Chinese medicine can have a value range, clinically be adjusted further according to situations such as state of an illness weight, patient's constitution It is whole；
Preferably, the Chinese medicine is made of the raw material of following parts by weight：
Semen Cuscutae：2 parts
Ramulus Taxilli：5 parts
Teasel root：3.33 part
Folium artemisiae argyi：1 part
Cortex Eucommiae：1.66 part
Radix Codonopsis：5 parts
Rhizoma Atractylodis Macrocephalae：1.66 part
Poria cocos：2 parts.
The auxiliary material preferably includes sodium alginate, gelatin, glycerol and water.The dosage of auxiliary material can be by those skilled in the art It is determined according to specific production method.
Gynaecology of Guangzhou Liwan District T.C.M. Hospital (former specialized department for sterility namely applicant) is as in national level Pivot Subjects, gynaecology of State Administration of Traditional Chinese Medicine cooperative groups infertility and fetal irritability disease Deputy Chief of Branch's unit are cured, by more than 20 The patient of year treatment more than 30 ten thousand person-times of threatened abortions and recurrent miscarriage, statistics find that " speen-kidney dificiency, the debility of chong and ren channels " is clinical Most common card type.
It is found based on above, this patent devises above-mentioned Chinese medicine preparation, and Radix Codonopsis is tonified Qi of the kidney in side, Rhizoma Atractylodis Macrocephalae invigorating the spleen benefit Gas, tocolysis, cloud Siberian cocklebur invigorating the spleen excreting dampness, Cortex Eucommiae tonifying liver and kidney and strengthening bones and muscles, tocolysis, Semen Cuscutae tonifying kidney and benefiting sperm, tocolysis, Ramulus Taxilli nourish liver Kidney, nourishing blood and preventing abortion, teasel root (also known as teasel, dipsacus root) tonifying liver is dirty, adjusts blood vessels, only threatened abortion, folium artemisiae argyi rationale blood, expel cold-dampness, Wen Jing, Hemostasis, tocolysis.The benefits of medicine-feeding shares, and is pasted on SHENQUE acupoint, and acting on punching by channels and collaterals appoints, and tocolysis is rushed in kidney tonifying of gathering altogether admittedly.
Good Chinese medicine preparation, is that medication is precise and appropriate, the present invention join Tu parasitisms cream with the tocolysis side head " SHOUTAI WAN " (Semen Cuscutae, Ramulus Taxilli, teasel root, folium artemisiae argyi) based on side, be added in strengthening the spleen and replenishing qi substantially square " Sijunzi Tang " (Radix Codonopsis, Poria cocos, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae) Three taste medicines, add kidney-reinforcing drug Cortex Eucommiae, effect invigorating the spleen, kidney tonifying, QI invigorating, Gu Chong, tocolysis.One eight tastes medicine can embody completely The main idea of tocolysis, compares 20 multi-flavor medicines (104623502 A of CN), and the dynamics of tocolysis is just eager to excel very much.
The production method of above-mentioned ginseng Tu parasitism cream, includes the following steps：
Chinese medicine folium artemisiae argyi, Rhizoma Atractylodis Macrocephalae are ground into fine powder；Remaining Six-element Chinese medicine is mixed, is added water to cook 1 time or more, merges and decocts Liquid, filtering, concentrates and sequentially adds sodium alginate, gelatin, glycerol and water with folium artemisiae argyi, Rhizoma Atractylodis Macrocephalae fine powder mixing for medicinal extract, be warming up to 60 DEG C, ginseng Tu parasitism cream is made after stirring evenly；Obtained ginseng Tu parasitism cream shows brown to sepia, gas micro-perfume.
The decoction preferably decocts 1 hour every time；
The concentration is that concentration is heated at -0.08MPa, 70~80 DEG C；
Preferably, the medicinal extract, density 1.35g/cm3(55 DEG C of measuring temperature).
One seed ginseng Tu parasitisms paste, and are made after joining the tabletting of Tu parasitism cream, lid lining, slice.
The ginseng Tu parasitisms cream and ginseng Tu parasitisms patch of the present invention, strengthening the spleen and replenishing qi, kidney tonifying Gu Chong.Cure mainly spleen kidney deficiency, punching is appointed not Admittedly cause it is pregnant after colporrhagia, lower abdomen secret anguish, with the soreness of waist, knee is soft or irregular colporrhagia, and mouth is light, clear abundant urine, and stool is dilute Half congealed, pale tongue with white fur, arteries and veins is thin and delicate, i.e. threatened abortion, habitual abortion, the diseases such as menstrual disorder.
Join Tu parasitisms and paste external application, is affixed on navel.One time one patch, it is 8 hours deposited, once a day.
In current tocolysis Chinese medicine external form of medication, the drug ingedient of sachet is not directly contacted with patient, only drug " nature and flavor " enter human body by respiratory system.Chinese medicine is so-called " yang transforming qi, yin shaping up body ", and the tangible part of drug can not enter people Body, and pregnant born of the same parents' tire, belong to tangible object, most shade tolerant blood nourishes, so method is difficult to be optimal curative effect.
Stifling refers to generating steam by Heating Drug, so that drug ingedient is entered human body, advantage by body surface by fuel factor It is the volatilization and absorption that fuel factor can accelerate drug, but in gestational patients, fuel factor may disturb channels and collaterals, lead to movement of the foetus Uneasiness occurs, therefore should not use.
Body surface is smeared and point-application is all percutaneous dosing, and drug can be made to be absorbed into blood by skin, compare it His external application method, it is preferably to be used for tocolysis patient.
But the drug dose that body surface is smeared is smaller, and drug is exposed to air, it is easy to air-dry and influence to absorb.Point-application Drug have certain thickness, be not easy to air-dry, can stablize, enduringly as blood circulation diffuses to whole body.And stick dosage form side Just it uses and carries, patient compliance is relatively high, for selection optimal in external used medicine.
In terms of the selection for sticking acupuncture point, navel is also known as SHENQUE acupoint, is the congenital base of a fruit, and the Qishe of the day after tomorrow rushes, appoints, superintends and directs three Arteries and veins crosses, and claims in " source and three discriminations ", and logical with hundred pulse-phases, the inline vital organs of the human body reach four limbs bones of the body collectively, be coordinating Chong and Conception Vessels qi and blood most Excellent selection.In terms of anatomical angulation, it is at the final closure of stomach wall in embryonic development, and subcutaneous tissue is few, and skin sensitivity is high, Vascular distribution is special, and blood supply is abundant, and permeability is strong, is directly absorbed convenient for drug, receives good effect.And movement of the foetus is not Peace, most common card type are " speen-kidney dificiency, the debility of chong and ren channels ", SHENQUE acupoint be located in, it is lower it is burnt between, and be pneumatic place between kidney, It is in close relations with spleen, stomach, kidney, for improving spleen kidney, and enhancing gastrointestinal absorption function, even more best selection.
The ginseng Tu parasitisms patch energy strengthening the spleen and replenishing qi of the present invention, admittedly tocolysis is rushed, and use sticks agent, passes through acupuncture point, navel skin It absorbs.Without oral, do not aggravate stomach and intestine burden, can guarantee drug can effectively, stablize, enduringly absorb, in tocolysis process In be a kind of very superior method.
The present invention has the following advantages and effects with respect to the prior art：
1, ginseng Tu parasitism cream of the invention is clinical experience side for many years, has effects that tocolysis is rushed in kidney tonifying admittedly, for spleen kidney Two empty, the debility of chong and ren channels threatened abortions and fetal irritability, it is curative for effect.The effect of to further increase this prescription, ensures the quality of the pharmaceutical preparations, Facilitate patient to carry and solve traditional Chinese medicine and decoct loaded down with trivial details defect, the present invention is further developed as ointment patch (ginseng Tu Parasitism patch), it is convenient for carrying and uses.
2, ginseng Tu parasitism patch of the invention is administered by SHENQUE acupoint (navel).《Prescriptions for Universal Relief》Claim：" navel person, Qi Ye, root This beginning of source generates place, there is raw not poor justice ".Umbilical region is the base of a fruit that life maintains for fetus, and zang-fu diseases pass through umbilical region Administration can guide drugs to illness station.SHENQUE acupoint is located at Qizhong, and drug can penetrate through channels and collaterals by navel eye by act on whole body, and bottom left thereon Where the right side is the tortuous convergence of stomach and intestine, more can invigorating the spleen and stomach, reinforce curative effect of medication.
3, the most card type of threatened abortion patient is speen-kidney dificiency, and it is pregnant after will appear due to hormonal effects, many patients The symptom that spleen and stomach function declines, such as Nausea and vomiting, poor, difficult defecation of receiving.The ginseng Tu parasitism patch of the present invention is mended with invigorating the spleen Kidney emphasizes the congenital foundation (kidney) admittedly rushing based on tocolysis, is improved jointly with the foundation of acquired constitution (taste), is suitable for most of tocolysis Patient.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Embodiment
The production method of one seed ginseng Tu parasitisms patch, includes the following steps：
Prescriptions of traditional Chinese medicine is：
Semen Cuscutae 1105g Ramulus Taxilli 2770g teasel root 1850g folium artemisiae argyis 555g
Cortex Eucommiae 920g Radix Codonopsis 2770g Rhizoma Atractylodis Macrocephalae 920g Poria cocos 1105g；
Above eight taste, folium artemisiae argyi, Rhizoma Atractylodis Macrocephalae are ground into fine powder, spare；The Six-elements such as remaining Semen Cuscutae add water to cook twice, first Secondary plus 8 times of amount water, second plus 6 times of amount water, decoct 1 hour every time, and filtration, filtrate merges, and decompression (- 0.08MPa, 70~80 DEG C) be concentrated into the medicinal extract that relative density is about 1.35 (55 DEG C) and sequentially add sodium alginate with folium artemisiae argyi, Rhizoma Atractylodis Macrocephalae fine powder mixing 975g, gelatin 750g, glycerine 1125g and appropriate purified water are heated up to 60 DEG C, stir 20 minutes, stir evenly rear tabletting, cover Lining, slice, be made 1000 patches to get.
Guangzhou Liwan District T.C.M. Hospital's specialized department for sterility is national Chinese medicine Pivot Subjects, fetal irritability (first megastream Production) be one of emphasis disease of training, annual outpatient service and ward there are about 1.5 ten thousand person-times of threatened abortions and patients with recurrent spontaneous abortion into Row diagnosis and treatment.
By the use in more than 20 years, more than 30 ten thousand person-times of statistics, it was demonstrated that ginseng Tu parasitism patch of the invention has played heavier The effect wanted.In the hospital, there are about nearly 10,000 person-times of patients to use the patch, total effective rate especially right up to 85% or more every year The fetal irritability of spleen kidney both deficiency type has very ideal curative effect.
By random inspection principle, it is infertile to extract Guangzhou Liwan District T.C.M. Hospital out by retrospective GCP clinical research methods (diagnostic criteria is to be worked out according to Ministry of Health of the People's Republic of China to 254 threatened abortion patients of sterile training ward treatment 《New Chinese medicine guideline of clinical investigations》In the guideline of clinical investigations of threatened abortion " new Chinese medicine treat "), extracted out Case in all patients be applied with ginseng Tu parasitisms patch.
With reference to the guideline of clinical investigations of new Chinese medicine treatment threatened abortion, i.e., " cure " standard is curative effect determinate standard Follow-up was to gestation three months or more, and embryonic development is all right, the symptoms such as no abdominal pain and colporrhagia；" improvement " is follow-up to pregnant It is pregnent three months, embryonic development is normal, occasionally there is the symptoms such as abdominal pain and colporrhagia；" not being cured " is that Early-stage cervical cancer occurs for embryo.
Its treatment results shows that, wherein curing 225 person-times, cure rate is up to 88.58%, and it is 21 person-times to improve, total effective rate Reach 96.9%.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, it is other it is any without departing from the spirit and principles of the present invention made by changes, modifications, substitutions, combinations, simplifications, Equivalent substitute mode is should be, is included within the scope of the present invention.

Claims (6)

1. a seed ginseng Tu parasitism cream, it is characterised in that be made by Chinese medicine and auxiliary material；
The Chinese medicine is made of the raw material of following parts by weight：
Semen Cuscutae：2-8 parts
Ramulus Taxilli：4-12 parts
Teasel root：3-10 parts
Folium artemisiae argyi：1 part
Cortex Eucommiae：1-5 parts
Radix Codonopsis：4-12 parts
Rhizoma Atractylodis Macrocephalae：1-5 parts
Poria cocos：2-8 parts.
2. ginseng Tu parasitism cream according to claim 1, it is characterised in that：The Chinese medicine by following parts by weight raw material Composition：
Semen Cuscutae：2 parts
Ramulus Taxilli：5 parts
Teasel root：3.33 part
Folium artemisiae argyi：1 part
Cortex Eucommiae：1.66 part
Radix Codonopsis：5 parts
Rhizoma Atractylodis Macrocephalae：1.66 part
Poria cocos：2 parts.
3. ginseng Tu parasitism cream according to claim 1, it is characterised in that：The auxiliary material includes sodium alginate, gelatin, sweet Oil and water.
4. the production method that claim 1-3 any one of them joins Tu parasitism cream, it is characterised in that include the following steps：
Chinese medicine folium artemisiae argyi, Rhizoma Atractylodis Macrocephalae are ground into fine powder；Remaining Six-element Chinese medicine is mixed, is added water to cook 1 time or more, decoction liquor is merged, Filtering, concentrates and sequentially adds sodium alginate, gelatin, glycerol and water with folium artemisiae argyi, Rhizoma Atractylodis Macrocephalae fine powder mixing for medicinal extract, be warming up to 60 DEG C, ginseng Tu parasitism cream is made after stirring evenly.
5. production method according to claim 4, it is characterised in that：The concentration, be -0.08MPa, 70~80 DEG C Lower heating concentration.
6. a seed ginseng Tu parasitisms paste, it is characterised in that：It is by the tabletting of claim 1-3 any one of them ginseng Tu parasitism cream, lid It is made after lining, slice.
CN201810674411.7A 2018-06-27 2018-06-27 A kind of ginseng Tu parasitism cream of external application and preparation method thereof Pending CN108653373A (en)

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