Background technology
Kidney is the vitals of human body, its basic function generates urine, so as to removing interior metabolism product and some refuse, poisonous substance, retain moisture and other utilities through heavy absorption function simultaneously, as glucose, protein, aminoacid, sodium ion, potassium ion, sodium bicarbonate etc., to regulate water, electrolyte balance and to safeguard acid-base balance.Kidney also has endocrine function simultaneously, and generating feritin, erythropoietin, activity of vitamin d3, prostaglandin, kassinin kinin etc., is again the degraded place of body part endocrine hormone and the target organ of kidney pheromone.These functions of kidney, ensure that the stable of organismic internal environment, metabolism are normally carried out.
Chinese medicine thinks that kidney is human body " the congenital foundation ", and taste are " the foundation of acquired constitution ", and kidney and taste are mutual subsidy, mutual dependence for existence, the main Physiological Function of kidney is store essential substances, main water, main improving inspiration by invigorating kidney-QI, main reproduction, the raw marrow of main bone, has one's ideas straightened out in ear, its Hua Fa.Kidney is owing to keeping congenital essence, for internal organs negative and positive basis, also be the source of growth in humans, growth, reproduction, that vital movement is basic, spleen sun relies on the replenishing vital QI with drugs of warm nature competence exertion transporting effect of kidney yang, it is weak that insufficiency of kidney-YANG can cause deficiency of spleen-YANG, transformation failure of spleen, occurs the symptoms of suffering from a deficiency of the kidney such as abdominal distention, dyspepsia, edema, ascites.
Deficiency of the kidney be suffer from a deficiency of the kidney, being commonly called as of deficiency of kidney-QI, the age along with people increases and modern society's work, life stress increase, and living habit is not good, has many people to suffer from a deficiency of the kidney.Suffer from a deficiency of the kidney and be divided into insufficiency of kidney-YANG and deficiency of the kidney yin, person's lumbago that the symptom of insufficiency of kidney-YANG is mainly manifested in insufficiency of kidney-YANG and send out cool, trick is ice-cold, with frequent micturition, and male's sexual is not normal, there are sexual impotence, seminal emission, premature ejaculation etc., the cardinal symptom of deficiency of the kidney yin shows as deficiency of the kidney yin patient waist knee joint ache, vertigo and tinnitus, insomnia and dreamful sleep, and man's postcoital protrusion is easily lifted, seminal emission, the amenorrhea of women's infrequent menstruation, or see metrorrhagia, emaciated physique, hectic fever night sweat.Have some the kidney invigorating products to suffer from a deficiency of the kidney certain effect to treatment in the market, but effect is undesirable.
Summary of the invention
The object of the present invention is to provide a kind of kidney tonifying mixture, can strengthening by means of tonics, essence-enriching kidney-nourishing, replenishing QI to invigorate the spleen, the invention also discloses the preparation method of described kidney tonifying mixture.
For achieving the above object, the technical scheme that the present invention takes is: a kind of kidney tonifying mixture, the active component of described kidney tonifying mixture is made up of the raw material of following portions by weight: Fructus Jujubae 25-30 part, Radix Astragali 20-25 part, Poria 15-20 part, Cornu Cervi Degelatinatum 15-20 part, Radix Rehmanniae Preparata 15-20 part, Radix Angelicae Sinensis 15-20 part, Radix Rehmanniae 10-15 part, Semen Allii Tuberosi 10-15 part, Fructus Corni 10-15 part, Fructus Lycii 10-15 part, Radix Codonopsis 10-15 part, Carapax Et Plastrum Testudinis 10-15 part, Fructus Hordei Germinatus 10-15 part, Radix Notoginseng 10-15 part, Herba Cistanches 10-15 part, Radix Ophiopogonis 5-8 part, Cortex Cinnamomi 5-8 part, Radix Ginseng 2-5 part, Fructus Schisandrae Chinensis 2-5 part.
Wherein, the parts by weight of the raw material of the active component of described kidney tonifying mixture are preferably: 30 parts, Fructus Jujubae, the Radix Astragali 22 parts, 18 parts, Poria, Cornu Cervi Degelatinatum 18 parts, Radix Rehmanniae Preparata 18 parts, Radix Angelicae Sinensis 18 parts, Radix Rehmanniae 12 parts, Semen Allii Tuberosi 12 parts, Fructus Corni 12 parts, Fructus Lycii 12 parts, Radix Codonopsis 12 parts, Carapax Et Plastrum Testudinis 12 parts, 12 parts, Fructus Hordei Germinatus, Radix Notoginseng 12 parts, Herba Cistanches 12 parts, Radix Ophiopogonis 5 parts, Cortex Cinnamomi 5 parts, Radix Ginseng 2 parts, Fructus Schisandrae Chinensis 2 parts.
Prepare the method for above-mentioned kidney tonifying mixture, comprise the following steps:
(1) take each crude drug by ratio of weight and the number of copies, add crude drug weight 4-6 water doubly, boil 45 minutes;
(2) be 1.2-1.5 by concentration of liquid medicine to the proportion after boiling, centrifugally go precipitation;
(3) in concentrated medicinal liquid, add betacyclodextrin 1% (g/mL), aspartame 0.02% (g/mL), citric acid 0.1% (g/mL), is filled into bottle, then sterilizing and labeling, to obtain final product.
The property of medicine and the pharmacological action of each prescription of the present invention are as follows:
Fructus Jujubae: sweet in the mouth, warm in nature.Return spleen, stomach warp.Can invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
The Radix Astragali: there is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
Poria: Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.
Cornu Cervi Degelatinatum: salty in the mouth, warm in nature; Return liver, kidney channel.Can warming the kidney to activate YANG, astringing to arrest bleeding.For spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule.
Radix Rehmanniae Preparata: sweet in the mouth; Warm in nature; Return liver, kidney channel; Enrich blood moist; Benefit essence fills out marrow; Cure mainly: blood tiger is sallow; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney dyspnea with rapid and short breath.
Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation; Cure mainly: all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Radix Rehmanniae: sweet-bitter flavor, cool in nature; Enter the heart, liver, spleen, lung four warp; Control fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon hinders constipation.
Semen Allii Tuberosi: acrid in the mouth, sweet; Warm in nature.Return kidney, Liver Channel; Can temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs, warm waist knee joint.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.Can liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapses, hidroschesis, promoting the production of body fluid to quench thirst.For soreness of waist and knee joint, dizziness and tinnitus, forgetful, emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses menoxenia, profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Fructus Lycii: sweet in the mouth; Property is put down.Can nourishing the liver; Nourishing kidney; Lung moistening.
Radix Codonopsis: have invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Carapax Et Plastrum Testudinis: salty in the mouth, sweet, cold nature.Return liver, kidney, heart channel.Nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.
Fructus Hordei Germinatus: sweet in the mouth, property is put down.Return spleen, stomach warp, Liver Channel.Can promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.Cure mainly food stagnation not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, and women weans.
Radix Notoginseng: sweet in the mouth, micro-hardship; Warm in nature.Return liver, stomach, the heart, lung, large intestine channel.Can stop blooding; Loose blood; Analgesic therapy.Congestive edema is flutterred, thoracic obstruction angor, lump in the abdomen for falling; Blood stasis amenorrhea; Dysmenorrhea; Puerperal, stasis of blood the moon was suffered from abdominal pain; Sore, carbuncle and painful swelling.
Herba Cistanches: sweet in the mouth, salty, warm in nature.Can kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature.GUIXIN, lung, stomach warp.Can YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet.Return kidney, spleen, the heart, Liver Channel.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.
Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian, heart channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves.
Fructus Schisandrae Chinensis: warm in nature; Sour in the mouth, sweet; Return lung, the heart, kidney channel.Astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.
Medicine of the present invention to the research of suffering from a deficiency of the kidney based on the traditional Chinese medical science, with reference to collocation rationally, based on the kidney invigorating, being taken into account the heart, liver, spleen, stomach, by nursing one's health the entirety of function of human body, can be reached preferably the kidney invigorating effect.
Detailed description of the invention
Be further described the specific embodiment of the present invention below in conjunction with embodiment, advantage and disadvantage of the present invention will be more clear along with description.But these embodiments are only exemplary, do not form any restriction to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments and replacement all fall within the scope of protection of the present invention.
Embodiment 1
Divide another name Fructus Jujubae 25kg, Radix Astragali 20kg, Poria 15kg, Cornu Cervi Degelatinatum 15kg, Radix Rehmanniae Preparata 15kg, Radix Angelicae Sinensis 15kg, Radix Rehmanniae 10kg, Semen Allii Tuberosi 10kg, Fructus Corni 10kg, Fructus Lycii 10kg, Radix Codonopsis 10kg, Carapax Et Plastrum Testudinis 10kg, Fructus Hordei Germinatus 10kg, Radix Notoginseng 10kg, Herba Cistanches 10kg, Radix Ophiopogonis 5kg, Cortex Cinnamomi 5kg, Radix Ginseng 2kg, Fructus Schisandrae Chinensis 2kg.Add the water of crude drug weight 4 times, boil 45 minutes; Be 1.2-1.5 by concentration of liquid medicine to the proportion after boiling, centrifugally go precipitation; In concentrated medicinal liquid, add betacyclodextrin 1% (g/mL), aspartame 0.02% (g/mL), citric acid 0.1% (g/mL), is filled into bottle, then sterilizing and labeling, to obtain final product.
Embodiment 2
Divide another name Fructus Jujubae 30kg, Radix Astragali 25kg, Poria 20kg, Cornu Cervi Degelatinatum 20kg, Radix Rehmanniae Preparata 20kg, Radix Angelicae Sinensis 20kg, Radix Rehmanniae 15kg, Semen Allii Tuberosi 15kg, Fructus Corni 15kg, Fructus Lycii 15kg, Radix Codonopsis 15kg, Carapax Et Plastrum Testudinis 15kg, Fructus Hordei Germinatus 15kg, Radix Notoginseng 15kg, Herba Cistanches 15kg, Radix Ophiopogonis 8kg, Cortex Cinnamomi 8kg, Radix Ginseng 5kg, Fructus Schisandrae Chinensis 5kg.Add the water of crude drug weight 4 times, boil 45 minutes; Be 1.2-1.5 by concentration of liquid medicine to the proportion after boiling, centrifugally go precipitation; In concentrated medicinal liquid, add betacyclodextrin 1% (g/mL), aspartame 0.02% (g/mL), citric acid 0.1% (g/mL), is filled into bottle, then sterilizing and labeling, to obtain final product.
Embodiment 3
Divide another name Fructus Jujubae 30kg, Radix Astragali 22kg, Poria 18kg, Cornu Cervi Degelatinatum 18kg, Radix Rehmanniae Preparata 18kg, Radix Angelicae Sinensis 18kg, Radix Rehmanniae 12kg, Semen Allii Tuberosi 12kg, Fructus Corni 12kg, Fructus Lycii 12kg, Radix Codonopsis 12kg, Carapax Et Plastrum Testudinis 12kg, Fructus Hordei Germinatus 12kg, Radix Notoginseng 12kg, Herba Cistanches 12kg, Radix Ophiopogonis 5kg, Cortex Cinnamomi 5kg, Radix Ginseng 2kg, Fructus Schisandrae Chinensis 2kg.Add the water of crude drug weight 4 times, boil 45 minutes; Be 1.2-1.5 by concentration of liquid medicine to the proportion after boiling, centrifugally go precipitation; In concentrated medicinal liquid, add betacyclodextrin 1% (g/mL), aspartame 0.02% (g/mL), citric acid 0.1% (g/mL), is filled into bottle, then sterilizing and labeling, to obtain final product.
Clinical treatment observation
By the clinicing symptom observation to 822 routine Patients with Kidney Deficiency Types, patient is divided into insufficiency of kidney-YANG and deficiency of the kidney yin two class, every class is divided into four groups, and treatment group 1 patient takes the embodiment of the present invention 1 mixture every day once, each 20mL, within 1 month, is a course for the treatment of; Treatment group 2 patient takes 2-in-1 dose of the embodiment of the present invention every day once, each 20mL, within 1 month, is a course for the treatment of; Treatment group 3 patient takes the embodiment of the present invention 3 mixture every day once, each 20mL, within 1 month, is a course for the treatment of; Matched group patient daily the commercially available power of adopting mixture (Qingdao Haier Pharmaceutical Co., Ltd) once a day, each 20mL; Above four groups at treatments period without other treatment method, one month statistics curative effect.
To insufficiency of kidney-YANG patient, with decrease in edema, soreness of the waist and knees improves, and have a headache dizzy alleviating, and frequency symptoms is improved as effective standard, and the transference cures such as, sexual impotence, easily perspiration unable with edema, aversion to cold and cold limbs, soreness of the waist and knees are for criterion of cure.To deficiency of the kidney yin patient, improve with soreness of the waist and knees, vertigo and tinnitus alleviates, and insomnia alleviates, and hectic fever is reduced to effective standard, with soreness of the waist and knees, two skelasthenia, vertigo and tinnitus, alopecia tooth pine, night sweat, insomnia, xerostomia, yellowish urine, the transference cure such as to be hard and dry is criterion of cure.Concrete data are in table 1 and table 2.
Table 1 insufficiency of kidney-YANG patient outcomes
|
Treatment group 1(105 people) |
Treatment group 2(101 people) |
Treatment group 3(110 people) |
Matched group (108 people) |
Effective percentage |
49.5%(52 people) |
55.4%(56 people) |
57.3%(63 people) |
45.4%(49 people) |
Cure rate |
45.5%(50 people) |
34.7%(35 people) |
40.9%(45 people) |
30.6%(33 people) |
Inefficiency |
2.9%(3 people) |
9.9%(10 people) |
1.8%(2 people) |
24.1%(26 people) |
Total effective rate |
97.1% |
90.1 |
98.2% |
75.9% |
Table 2 deficiency of the kidney yin patient outcomes
|
Treatment group 1(98 people) |
Treatment group 2(100 people) |
Treatment group 3(105 people) |
Matched group (95 people) |
Effective percentage |
45.9%(45 people) |
47%(47 people) |
45.7%(48 people) |
31.6%(30 people) |
Cure rate |
42.9%(42 people) |
40%(40 people) |
47.6%(50 people) |
33.7%(32 people) |
Inefficiency |
11.2%(11 people) |
13%(13 people) |
6.7%(7 people) |
34.7%(33 people) |
Total effective rate |
88.8% |
87% |
93.3% |
65.3% |
Table 1 and table 2 data show kidney tonifying mixture of the present invention to insufficiency of kidney-YANG patient still to cure rate and the total effective rate of deficiency of the kidney yin patient, all higher than the commercially available power of adopting mixture to the effective percentage of these two groups of patients and cure rate.
Treatment case
1. grandson, female, 57 years old, accounting, headache and dizzy 5 years, head was numb, and shortness of breath and palpitation, conscious half body has formication, and insomnia and dreamful sleep is forgetful, and patient is impatient irritability usually, does things and aspires after perfection, again because job specification is tired over a long time.Red tongue, yellow and thin fur, stringy,thready and rapid pulse.Chinese medical discrimination belongs to deficiency of yang of liver and kidney yang hyperactivity.Take the mixture of the embodiment of the present invention 3 after 15 days, all diseases alleviate, and after taking 1 month, various symptom is eliminated.
2. Wang, man, 40 years old, complexion was shaken white, spontaneous perspiration, spiritlessness and weakness, soreness of the waist and knees, aversion to cold and cold limbs, and libido reduces, and has impotence and premature ejaculation symptom, is diagnosed as deficiency of kidney-YANG syndrome.Take 2-in-1 dose of the embodiment of the present invention after 1 month, above-mentioned symptom disappears.