CN105194298A - Traditional Chinese medicine oral solution for treating coronary heart diseases and preparation method of traditional Chinese medicine oral solution - Google Patents
Traditional Chinese medicine oral solution for treating coronary heart diseases and preparation method of traditional Chinese medicine oral solution Download PDFInfo
- Publication number
- CN105194298A CN105194298A CN201510759264.XA CN201510759264A CN105194298A CN 105194298 A CN105194298 A CN 105194298A CN 201510759264 A CN201510759264 A CN 201510759264A CN 105194298 A CN105194298 A CN 105194298A
- Authority
- CN
- China
- Prior art keywords
- parts
- filtrate
- radix
- chinese medicine
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a traditional Chinese medicine oral solution for treating coronary heart diseases and a preparation method of the traditional Chinese medicine oral solution. The traditional Chinese medicine oral solution is prepared from the following raw materials in parts by weight: 48-52 parts of astragalus, 13-17 parts of fructus trichosanthis, 38-42 parts of calcined dragon bone, 8-12 parts of white ginseng, 13-17 parts of allium macrostemon, 28-32 parts of concha margaritifera, 18-22 parts of radix ophiopogonis, 28-32 parts of salvia miltiorrhiza, 5-9 parts of sandalwood, 10-14 parts of schisandra chinensis, 4-8 parts of leeches, 28-32 parts of fried semen ziziphi spinosae, 13-17 parts of dogwoods, 2-6 parts of cassia twigs and 6-10 parts of honey-fried licorice roots. The traditional Chinese medicine oral solution has the effects of benefiting heart qi, tonifying heart yang, nourishing heart yin and stabilizing mind and will and is a traditional Chinese medicine composition which is safe, reliable, free of any toxic or side effects, high in effective component utilization ratio and capable of rapidly taking effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine oral liquid for the treatment of coronary heart disease, belong to the field of Chinese medicines.
Background technology
Coronary heart disease heart stricture of vagina pain, the traditional Chinese medical science is referred to as " thoracic obstruction ", its clinical main manifestations is suffocating pain over the chest, shortness of breath and palpitation, very then chest pain to the bone etc., a kind of commonly encountered diseases and frequently-occurring disease, patient is in the majority with middle-aged and elderly people, as treated not in time, often can secondary myocardial infarction and even extremely broken, the traditional Chinese medical science thinks that the etiology and pathology of angina pectoris mostly is " imbalance of YIN and YANG, qi-movement disturbance causes painstaking effort tired stagnant, blockage of the cardiac vessels, stagnation of QI and blood may bring about pain ", according to statistics, the whole world is every year because the number of angina pectoris death is more than ten million, it seriously compromises the mankind's particularly health of mid-aged population and life.Western medicine mainly nitrate compound, B receptor blocking agent and the calcium antagonist etc. of current treatment coronary heart disease, these medicines can only relief of symptoms, is difficult to effect a permanent cure, and has certain toxic and side effects, and treat angina pectoris Chinese patent medicine used in the current clinical practice of the traditional Chinese medical science as FUFANG DANSHEN PIAN, it is not comprehensive that DANQI PIAN etc. also also exist medication mostly, curative effect is low, the defect that onset is slow, and toward contact needs and multi-medicament drug combination, although the action intensity of the single target spot of Chinese medicine is lower than Western medicine, but its multipath, Mutiple Targets, dynamic whole is treated, the characteristic that toxic and side effects is little is then far from reached by Western medicine, the Comprehensive Treatment effect of the Chinese patent medicine of determined curative effect will exceed Western medicine, but the treatment by Chinese herbs time of routine is long, be difficult to fundamentally cure coronary heart disease, Hospitals at Present treatment coronary heart disease develops very fast in nearly twenty or thirty year really, but present problems faced is that the sickness rate of coronary heart disease is very high, the patient needing treatment is also more and more, this is also open question all the time, although the Drug therapy of hospital has reasonable clinical efficacy in addition, but also may there is some bad reactions, therefore carrying out treatment with Chinese medicine is safest approach.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine oral liquid for the treatment of coronary heart disease, it has effect of the beneficial motive, reinforcing the heart sun, the moon that nourishes heart, centering will.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine oral liquid for coronary heart disease, be made up of following raw material: Radix Astragali 48-52 part, Fructus Trichosanthis 13-17 part, Os Draconis (calcined) 38-42 part, Radix Ginseng 8-12 part, Bulbus Allii Macrostemonis 13-17 part, Concha Margaritifera 28-32 part, Radix Ophiopogonis 18-22 part, Radix Salviae Miltiorrhizae 28-32 part, Lignum Santali Albi 5-9 part, Fructus Schisandrae Chinensis 10-14 part, Hirudo 4-8 part, Semen Ziziphi Spinosae (parched) 28-32 part, Fructus Corni 13-17 part, Ramulus Cinnamomi 2-6 part, Radix Glycyrrhizae Preparata 6-10 part.
Preferably, each parts by weight of raw materials is: the Radix Astragali 50 parts, Fructus Trichosanthis 15 parts, Os Draconis (calcined) 40 parts, Radix Ginseng 10 parts, Bulbus Allii Macrostemonis 15 parts, Concha Margaritifera 30 parts, Radix Ophiopogonis 20 parts, Radix Salviae Miltiorrhizae 30 parts, 7 parts, Lignum Santali Albi, Fructus Schisandrae Chinensis 12 parts, Hirudo 6 parts, Semen Ziziphi Spinosae (parched) 30 parts, Fructus Corni 15 parts, Ramulus Cinnamomi 4 parts, Radix Glycyrrhizae Preparata 8 parts.
Pharmacological action:
The Radix Astragali: nature and flavor with return through: sweet, temperature; Return lung, spleen channel, function with cure mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation; Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Fructus Trichosanthis: nature and flavor with return through: sweet, micro-hardship, cold; Return lung, stomach, large intestine channel, function with cure mainly: clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation; For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Os Draconis (calcined): sweet, puckery is flat; GUIXIN, liver, kidney channel; There is tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, the effect of promoting tissue regeneration and ulcer healing; Demented with controlling infantile convulsion, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Radix Ginseng: nature and flavor: sweet, flat, micro-hardship, slightly cold; There is the function of tonifying QI to produce body fluid, the mind calming and mentality promoting, it can promote the production of body fluid, yin nourishing and clearind deficient heat; Various processing beyond Radix Ginseng Rubra, as Radix Ginseng, white sugar ginseng, suncured white ginseng root etc., are generally referred to as Radix Ginseng.
Bulbus Allii Macrostemonis: nature and flavor with return through: pungent, bitter, temperature; Return lung, stomach, large intestine channel, function with cure mainly: activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving; For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery.
Concha Margaritifera: nature and flavor with return through: salty, cold; Return liver, heart channel, function with cure mainly: suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight; Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Radix Ophiopogonis: nature and flavor with return through: sweet, micro-hardship, is slightly cold; GUIXIN, lung, stomach warp, function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; For dryness of the lung dry cough; Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Radix Salviae Miltiorrhizae: nature and flavor with return through: bitter, be slightly cold; GUIXIN, Liver Channel, function with cure mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness; For menoxenia, amenorrhea dysmenorrhea, note of the ancient Chinese abdominal mass is gathered, breast ventral spine pain, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Lignum Santali Albi: nature and flavor with return through: pungent, temperature; Return spleen, stomach, the heart, lung meridian, function with cure mainly: circulation of qi promoting warming middle-JIAO, appetizing pain relieving; For QI stagnated by cold, chest pain, stomachache, stomachache lack of appetite; Coronary heart disease, angina pectoris.
Fructus Schisandrae Chinensis: nature and flavor with return through: sour, sweet, temperature; Return lung, the heart, kidney channel, function with cure mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Hirudo: nature and flavor with return through: salty, bitter, flat; Slightly poisonous; Return Liver Channel, function with cure mainly: removing blood stasis, removing blood stasis, stimulates the menstrual flow; Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.
Semen Ziziphi Spinosae: nature and flavor with return through: sweet, sour, flat; Return liver, gallbladder, heart channel, function with cure mainly: tonifying liver, mind calming, arresting sweating, promotes the production of body fluid; For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Fructus Corni: nature and flavor with return through: sour, puckery, tepor; Return liver, kidney channel, function with cure mainly: liver and kidney tonifying, essence astringing and desertion stemming; For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed; Interior-heat is quenched one's thirst.
Ramulus Cinnamomi: nature and flavor with return through acrid, sweet, warm; GUIXIN, lung, urinary bladder channel, function with cure mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins; For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Glycyrrhizae Preparata: meridian distribution of property and flavor: sweet is flat; GUIXIN, lung, spleen, stomach warp; Function cures mainly: spleen reinforcing stomach function regulating, Yiqi and vein recovery; For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse, can separate Radix Aconiti Lateralis Preparata poison, zhigancao decoction has benefiting qi and nourishing yin, and activate yang multiple arteries and veins therapeutic efficiency.
Another technical problem to be solved by this invention is to provide a kind of preparation method preparing above-mentioned Chinese medicine oral liquid.
Another technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a preparation method for the Chinese medicine oral liquid of coronary heart disease, be prepared from by following methods:
(1) get the raw material Radix Astragali, Fructus Trichosanthis, Radix Ginseng, Bulbus Allii Macrostemonis, Concha Margaritifera, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Lignum Santali Albi, Fructus Schisandrae Chinensis, Hirudo, Fructus Corni, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata clean after put into boiling machine, with cold water soak 30-50 minute, then above-mentioned raw materials volume 5-10 soak by water secondary is doubly added, each 2-4 hour, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) get raw material Semen Ziziphi Spinosae (parched) to clean, dry, after pulverizing, put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(3) get raw material Os Draconis (calcined) to clean, dry, pulverize and put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(4) gained filtrate in gained filtrate in gained filtrate in step (1) and step (2) and step (3) is put into container to be fully uniformly mixed, agitator revolution is 300-500r/min, then the ethanol of 50-80% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilters, obtain admixing medical solutions, for subsequent use;
(5) gained admixing medical solutions in step (4) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-50nm, and the pressure limit crossed in filter fly is 0.1-0.4MPa, and the scope of the crossflow velocity in filter process is 3-6m/s, obtain filtrate, for subsequent use;
(6) gained filtrate in step (5) is sent into receiver, in receiver, be evaporated to the clear paste of relative density 1.01-1.08 during 60-65 DEG C, obtain clear paste, for subsequent use;
(7) by gained clear paste in step (6) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in soda-lime glass tubular oral liquid bottle again, and fill is rolled lid and is placed on 95-98 DEG C of condition, sterilizing 15-18min, warehouse-in is finished product, must treat the Chinese medicine oral liquid of coronary heart disease.
Preferably, a kind of preparation method for the treatment of the Chinese medicine oral liquid of coronary heart disease, is prepared from by following methods:
(1) get the raw material Radix Astragali, Fructus Trichosanthis, Radix Ginseng, Bulbus Allii Macrostemonis, Concha Margaritifera, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Lignum Santali Albi, Fructus Schisandrae Chinensis, Hirudo, Fructus Corni, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata clean after put into boiling machine, by cold water soak 30 minutes, then the soak by water secondary of above-mentioned raw materials volume 10 times is added, each 2 hours, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) get raw material Semen Ziziphi Spinosae (parched) to clean, dry, after pulverizing, put into boiling machine, by cold water soak 30 minutes, then add the soak by water secondary of above-mentioned raw materials volume 10 times, each 2 hours, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(3) get raw material Os Draconis (calcined) to clean, dry, pulverize and put into boiling machine, by cold water soak 30 minutes, then add the soak by water secondary of above-mentioned raw materials volume 10 times, each 2 hours, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(4) gained filtrate in gained filtrate in gained filtrate in step (1) and step (2) and step (3) is put into container to be fully uniformly mixed, agitator revolution is 400r/min, then the ethanol of 70% is added by volume, leave standstill 48 hours, filter, filtrate recycling ethanol, refilters, obtain admixing medical solutions, for subsequent use;
(5) gained admixing medical solutions in step (4) is put into ultrafilter to filter, the average pore size of the filter membrane of described ultrafilter is 50nm, and the pressure limit crossed in filter fly is 0.4MPa, and the scope of the crossflow velocity in filter process is 5m/s, obtains filtrate, for subsequent use;
(6) gained filtrate in step (5) is sent into receiver, when being evaporated to 65 DEG C in receiver, the clear paste of relative density 1.08, obtains clear paste, for subsequent use;
(7) by gained clear paste sodium hydroxide solution adjust ph to 6.8 in step (6), then embedding is in soda-lime glass tubular oral liquid bottle, and fill is rolled lid and is placed on 98 DEG C of conditions, sterilizing 15min, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of coronary heart disease.
Beneficial effect: the present invention has effect of the beneficial motive, reinforcing the heart sun, the moon that nourishes heart, centering will, be a kind of safe and reliable, without any side effects, effective ingredient utilization rate is high, the Chinese medicine composition of instant effect.
The present invention adopts pure Chinese medicine to be raw material, according to pathogenic factor and the Clinical symptoms of coronary heart disease, under instruction of Chinese Medicine theory, carry out prescription be prepared from the basis not being raw-material activity, show through clinical efficacy, this medicine has definite curative effect to coronary heart disease, is a kind of ideal treatment medication of patients with coronary heart disease.
Model case
Case 1: Mr. Yu, 66 years old, medical history: main suit's paroxysmal precordial pain 10 days, increase the weight of 3 days, patient felt precordialgia when climbing the mountain before 7 days, and takeed on radiation left, can alleviate through having a rest, also have analogue to occur over 3 days during work, each lasting 3-5 minute, hospital examines as coronary heart disease, take Drug therapy of the present invention 10 days, the conscious obvious minimizing of patient after treatment, after taking three courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 2: Mr. Jin, 56 years old, medical history: main suit's squeezing property chest pain, companion's Nausea and vomiting 3 hours, feels chest pain suddenly when patient defecated before 3 hours, in squeezing property, there is dying sense, have a rest and suck nitroglycerin and all can not alleviate, companion's profuse sweating, to feel sick, vomitted 2 times, hospital examines as coronary heart disease, takes Drug therapy of the present invention 10 days, the conscious obvious minimizing of patient after treatment, after taking three courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 3: Xiang Mr., 60 years old, medical history: main suit's persistence precordialgia 2 hours, sense precordialgia of dashing forward when removing weight before 2 hours, accompanies the acid of left shoulder arm swollen, companion feels suffocated, weak, perspiration, hospital examines as coronary heart disease, takes Drug therapy of the present invention 10 days, the conscious obvious minimizing of patient after treatment, after taking three courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 4: Mr. Shu, 50 years old, medical history: patient main suit, suffered from coronary heart disease 1 year, cardiopalmus, the symptom such as uncomfortable in chest is recurred after nearly one week anger, cardiopalmus, uncomfortable in chest repeatedly, increase the weight of one week, hospital examines as coronary heart disease, take Drug therapy of the present invention 10 days, the conscious obvious minimizing of patient after treatment, after taking four courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 5: Mrs Li, 62 years old, medical history: patient is because precordialgia, can not alleviate after rest, examine, be diagnosed as coronary heart disease, take Drug therapy of the present invention 10 days, the conscious obvious minimizing of patient after treatment, after taking three courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 6: Mrs Wei, 48 years old, medical history: have paroxysmal cardiopalmus, uncomfortable in chest, examine as coronary heart disease, take Drug therapy of the present invention 10 days, the conscious obvious minimizing of patient after treatment, after taking three courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappeared, and follows up a case by regular visits to 1 year without recurrence.
Case 7: Mr. Qi, 46 years old, medical history: often have uncomfortable in chest, angina pectoris, and have premature beat, examine as coronary heart disease, take Drug therapy of the present invention 10 days, conscious uncomfortable in chest, premature beat disappearance, also do not have angina pectoris to occur, after taking three courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Clinical data
Physical data: patients with coronary heart disease 70 example, male 40 example, women 30 example, age 38-75 year.
Diagnostic criteria: 1. clinical manifestation: mainly comprise sings and symptoms, has typical angina pectoris symptom; 2. electrocardiogram: have its typical ECG Change; 3. coronarography.
Therapeutic Method: take oral liquid of the present invention, every day 2 times, each 30ml 10 days is a course for the treatment of.
Curative effect determinate standard: recovery from illness: the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: the blood supply of electrocardio diagram artery chronic improves, and malaise symptoms alleviates or partial disappearance, and energy and muscle power strengthen; Invalid: malaise symptoms is unchanged.
Therapeutic effect: by this side treatment patients with coronary heart disease 70 example, recovery from illness 60 example, effective 10 examples, invalid 0 example, total effective rate 100%.
Detailed description of the invention
Embodiment 1
The present invention treats the preparation of coronary heart disease Chinese medicine oral liquid, and the weight portion of each raw material is: the Radix Astragali 52 parts, Fructus Trichosanthis 17 parts, Os Draconis (calcined) 42 parts, Radix Ginseng 12 parts, Bulbus Allii Macrostemonis 17 parts, Concha Margaritifera 32 parts, Radix Ophiopogonis 22 parts, Radix Salviae Miltiorrhizae 32 parts, 9 parts, Lignum Santali Albi, Fructus Schisandrae Chinensis 14 parts, Hirudo 8 parts, Semen Ziziphi Spinosae (parched) 32 parts, Fructus Corni 17 parts, Ramulus Cinnamomi 6 parts, Radix Glycyrrhizae Preparata 10 parts;
Be prepared from by following methods:
(1) get the raw material Radix Astragali, Fructus Trichosanthis, Radix Ginseng, Bulbus Allii Macrostemonis, Concha Margaritifera, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Lignum Santali Albi, Fructus Schisandrae Chinensis, Hirudo, Fructus Corni, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata clean after put into boiling machine, with cold water soak 30-50 minute, then above-mentioned raw materials volume 5-10 soak by water secondary is doubly added, each 2-4 hour, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) get raw material Semen Ziziphi Spinosae (parched) to clean, dry, after pulverizing, put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(3) get raw material Os Draconis (calcined) to clean, dry, pulverize and put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(4) gained filtrate in gained filtrate in gained filtrate in step (1) and step (2) and step (3) is put into container to be fully uniformly mixed, agitator revolution is 300-500r/min, then the ethanol of 50-80% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilters, obtain admixing medical solutions, for subsequent use;
(5) gained admixing medical solutions in step (4) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-50nm, and the pressure limit crossed in filter fly is 0.1-0.4MPa, and the scope of the crossflow velocity in filter process is 3-6m/s, obtain filtrate, for subsequent use;
(6) gained filtrate in step (5) is sent into receiver, in receiver, be evaporated to the clear paste of relative density 1.01-1.08 during 60-65 DEG C, obtain clear paste, for subsequent use;
(7) by gained clear paste in step (6) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in soda-lime glass tubular oral liquid bottle again, and fill is rolled lid and is placed on 95-98 DEG C of condition, sterilizing 15-18min, warehouse-in is finished product, must treat the Chinese medicine oral liquid of coronary heart disease.
Usage: oral, every day 2 times, each 30ml.
Embodiment 2
The present invention treats the preparation of coronary heart disease Chinese medicine oral liquid, and the weight portion of each raw material is: the Radix Astragali 50 parts, Fructus Trichosanthis 15 parts, Os Draconis (calcined) 40 parts, Radix Ginseng 10 parts, Bulbus Allii Macrostemonis 15 parts, Concha Margaritifera 30 parts, Radix Ophiopogonis 20 parts, Radix Salviae Miltiorrhizae 30 parts, 7 parts, Lignum Santali Albi, Fructus Schisandrae Chinensis 12 parts, Hirudo 6 parts, Semen Ziziphi Spinosae (parched) 30 parts, Fructus Corni 15 parts, Ramulus Cinnamomi 4 parts, Radix Glycyrrhizae Preparata 8 parts;
Be prepared from by following methods:
(1) get the raw material Radix Astragali, Fructus Trichosanthis, Radix Ginseng, Bulbus Allii Macrostemonis, Concha Margaritifera, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Lignum Santali Albi, Fructus Schisandrae Chinensis, Hirudo, Fructus Corni, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata clean after put into boiling machine, with cold water soak 30-50 minute, then above-mentioned raw materials volume 5-10 soak by water secondary is doubly added, each 2-4 hour, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) get raw material Semen Ziziphi Spinosae (parched) to clean, dry, after pulverizing, put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(3) get raw material Os Draconis (calcined) to clean, dry, pulverize and put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(4) gained filtrate in gained filtrate in gained filtrate in step (1) and step (2) and step (3) is put into container to be fully uniformly mixed, agitator revolution is 300-500r/min, then the ethanol of 50-80% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilters, obtain admixing medical solutions, for subsequent use;
(5) gained admixing medical solutions in step (4) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-50nm, and the pressure limit crossed in filter fly is 0.1-0.4MPa, and the scope of the crossflow velocity in filter process is 3-6m/s, obtain filtrate, for subsequent use;
(6) gained filtrate in step (5) is sent into receiver, in receiver, be evaporated to the clear paste of relative density 1.01-1.08 during 60-65 DEG C, obtain clear paste, for subsequent use;
(7) by gained clear paste in step (6) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in soda-lime glass tubular oral liquid bottle again, and fill is rolled lid and is placed on 95-98 DEG C of condition, sterilizing 15-18min, warehouse-in is finished product, must treat the Chinese medicine oral liquid of coronary heart disease.
Usage: oral, every day 2 times, each 30ml.
Embodiment 3
The present invention treats the preparation of coronary heart disease Chinese medicine oral liquid, and the weight portion of each raw material is: the Radix Astragali 48 parts, Fructus Trichosanthis 13 parts, Os Draconis (calcined) 38 parts, Radix Ginseng 8 parts, Bulbus Allii Macrostemonis 13 parts, Concha Margaritifera 28 parts, Radix Ophiopogonis 18 parts, Radix Salviae Miltiorrhizae 28 parts, 5 parts, Lignum Santali Albi, Fructus Schisandrae Chinensis 10 parts, Hirudo 4 parts, Semen Ziziphi Spinosae (parched) 28 parts, Fructus Corni 13 parts, Ramulus Cinnamomi 2 parts, Radix Glycyrrhizae Preparata 6 parts;
Be prepared from by following methods:
(1) get the raw material Radix Astragali, Fructus Trichosanthis, Radix Ginseng, Bulbus Allii Macrostemonis, Concha Margaritifera, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Lignum Santali Albi, Fructus Schisandrae Chinensis, Hirudo, Fructus Corni, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata clean after put into boiling machine, with cold water soak 30-50 minute, then above-mentioned raw materials volume 5-10 soak by water secondary is doubly added, each 2-4 hour, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) get raw material Semen Ziziphi Spinosae (parched) to clean, dry, after pulverizing, put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(3) get raw material Os Draconis (calcined) to clean, dry, pulverize and put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(4) gained filtrate in gained filtrate in gained filtrate in step (1) and step (2) and step (3) is put into container to be fully uniformly mixed, agitator revolution is 300-500r/min, then the ethanol of 50-80% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilters, obtain admixing medical solutions, for subsequent use;
(5) gained admixing medical solutions in step (4) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-50nm, and the pressure limit crossed in filter fly is 0.1-0.4MPa, and the scope of the crossflow velocity in filter process is 3-6m/s, obtain filtrate, for subsequent use;
(6) gained filtrate in step (5) is sent into receiver, in receiver, be evaporated to the clear paste of relative density 1.01-1.08 during 60-65 DEG C, obtain clear paste, for subsequent use;
(7) by gained clear paste in step (6) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in soda-lime glass tubular oral liquid bottle again, and fill is rolled lid and is placed on 95-98 DEG C of condition, sterilizing 15-18min, warehouse-in is finished product, must treat the Chinese medicine oral liquid of coronary heart disease.
Usage: oral, every day 2 times, each 30ml.
Claims (6)
1. treat a Chinese medicine oral liquid for coronary heart disease, it is characterized in that: be made up of following raw material: Radix Astragali 48-52 part, Fructus Trichosanthis 13-17 part, Os Draconis (calcined) 38-42 part, Radix Ginseng 8-12 part, Bulbus Allii Macrostemonis 13-17 part, Concha Margaritifera 28-32 part, Radix Ophiopogonis 18-22 part, Radix Salviae Miltiorrhizae 28-32 part, Lignum Santali Albi 5-9 part, Fructus Schisandrae Chinensis 10-14 part, Hirudo 4-8 part, Semen Ziziphi Spinosae (parched) 28-32 part, Fructus Corni 13-17 part, Ramulus Cinnamomi 2-6 part, Radix Glycyrrhizae Preparata 6-10 part.
2. a kind of Chinese medicine oral liquid for the treatment of coronary heart disease according to claim 1, is characterized in that: the weight portion of each raw material is: the Radix Astragali 50 parts, Fructus Trichosanthis 15 parts, Os Draconis (calcined) 40 parts, Radix Ginseng 10 parts, Bulbus Allii Macrostemonis 15 parts, Concha Margaritifera 30 parts, Radix Ophiopogonis 20 parts, Radix Salviae Miltiorrhizae 30 parts, 7 parts, Lignum Santali Albi, Fructus Schisandrae Chinensis 12 parts, Hirudo 6 parts, Semen Ziziphi Spinosae (parched) 30 parts, Fructus Corni 15 parts, Ramulus Cinnamomi 4 parts, Radix Glycyrrhizae Preparata 8 parts.
3. a kind of Chinese medicine oral liquid for the treatment of coronary heart disease according to claim 1, is characterized in that: the weight portion of each raw material is: the Radix Astragali 52 parts, Fructus Trichosanthis 17 parts, Os Draconis (calcined) 42 parts, Radix Ginseng 12 parts, Bulbus Allii Macrostemonis 17 parts, Concha Margaritifera 32 parts, Radix Ophiopogonis 22 parts, Radix Salviae Miltiorrhizae 32 parts, 9 parts, Lignum Santali Albi, Fructus Schisandrae Chinensis 14 parts, Hirudo 8 parts, Semen Ziziphi Spinosae (parched) 32 parts, Fructus Corni 17 parts, Ramulus Cinnamomi 6 parts, Radix Glycyrrhizae Preparata 10 parts.
4. a kind of Chinese medicine oral liquid for the treatment of coronary heart disease according to claim 1, is characterized in that: the weight portion of each raw material is: the Radix Astragali 48 parts, Fructus Trichosanthis 13 parts, Os Draconis (calcined) 38 parts, Radix Ginseng 8 parts, Bulbus Allii Macrostemonis 13 parts, Concha Margaritifera 28 parts, Radix Ophiopogonis 18 parts, Radix Salviae Miltiorrhizae 28 parts, 5 parts, Lignum Santali Albi, Fructus Schisandrae Chinensis 10 parts, Hirudo 4 parts, Semen Ziziphi Spinosae (parched) 28 parts, Fructus Corni 13 parts, Ramulus Cinnamomi 2 parts, Radix Glycyrrhizae Preparata 6 parts.
5. a kind of preparation method for the treatment of the Chinese medicine oral liquid of coronary heart disease according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) get the raw material Radix Astragali, Fructus Trichosanthis, Radix Ginseng, Bulbus Allii Macrostemonis, Concha Margaritifera, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Lignum Santali Albi, Fructus Schisandrae Chinensis, Hirudo, Fructus Corni, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata clean after put into boiling machine, with cold water soak 30-50 minute, then above-mentioned raw materials volume 5-10 soak by water secondary is doubly added, each 2-4 hour, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) get raw material Semen Ziziphi Spinosae (parched) to clean, dry, after pulverizing, put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(3) get raw material Os Draconis (calcined) to clean, dry, pulverize and put into boiling machine, with cold water soak 30-50 minute, then add above-mentioned raw materials volume 5-10 soak by water secondary doubly, each 2-4 hour, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(4) gained filtrate in gained filtrate in gained filtrate in step (1) and step (2) and step (3) is put into container to be fully uniformly mixed, agitator revolution is 300-500r/min, then the ethanol of 50-80% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilters, obtain admixing medical solutions, for subsequent use;
(5) gained admixing medical solutions in step (4) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-50nm, and the pressure limit crossed in filter fly is 0.1-0.4MPa, and the scope of the crossflow velocity in filter process is 3-6m/s, obtain filtrate, for subsequent use;
(6) gained filtrate in step (5) is sent into receiver, in receiver, be evaporated to the clear paste of relative density 1.01-1.08 during 60-65 DEG C, obtain clear paste, for subsequent use;
(7) by gained clear paste in step (6) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in soda-lime glass tubular oral liquid bottle again, and fill is rolled lid and is placed on 95-98 DEG C of condition, sterilizing 15-18min, warehouse-in is finished product, must treat the Chinese medicine oral liquid of coronary heart disease.
6. a kind of preparation method for the treatment of the Chinese medicine oral liquid of coronary heart disease according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) get the raw material Radix Astragali, Fructus Trichosanthis, Radix Ginseng, Bulbus Allii Macrostemonis, Concha Margaritifera, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Lignum Santali Albi, Fructus Schisandrae Chinensis, Hirudo, Fructus Corni, Ramulus Cinnamomi, Radix Glycyrrhizae Preparata clean after put into boiling machine, by cold water soak 30 minutes, then the soak by water secondary of above-mentioned raw materials volume 10 times is added, each 2 hours, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) get raw material Semen Ziziphi Spinosae (parched) to clean, dry, after pulverizing, put into boiling machine, by cold water soak 30 minutes, then add the soak by water secondary of above-mentioned raw materials volume 10 times, each 2 hours, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(3) get raw material Os Draconis (calcined) to clean, dry, pulverize and put into boiling machine, by cold water soak 30 minutes, then add the soak by water secondary of above-mentioned raw materials volume 10 times, each 2 hours, collecting decoction, filter, collect filtrate, obtain filtrate, for subsequent use;
(4) gained filtrate in gained filtrate in gained filtrate in step (1) and step (2) and step (3) is put into container to be fully uniformly mixed, agitator revolution is 400r/min, then the ethanol of 70% is added by volume, leave standstill 48 hours, filter, filtrate recycling ethanol, refilters, obtain admixing medical solutions, for subsequent use;
(5) gained admixing medical solutions in step (4) is put into ultrafilter to filter, the average pore size of the filter membrane of described ultrafilter is 50nm, and the pressure limit crossed in filter fly is 0.4MPa, and the scope of the crossflow velocity in filter process is 5m/s, obtains filtrate, for subsequent use;
(6) gained filtrate in step (5) is sent into receiver, when being evaporated to 65 DEG C in receiver, the clear paste of relative density 1.08, obtains clear paste, for subsequent use;
(7) by gained clear paste sodium hydroxide solution adjust ph to 6.8 in step (6), then embedding is in soda-lime glass tubular oral liquid bottle, and fill is rolled lid and is placed on 98 DEG C of conditions, sterilizing 15min, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of coronary heart disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510759264.XA CN105194298A (en) | 2015-11-10 | 2015-11-10 | Traditional Chinese medicine oral solution for treating coronary heart diseases and preparation method of traditional Chinese medicine oral solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510759264.XA CN105194298A (en) | 2015-11-10 | 2015-11-10 | Traditional Chinese medicine oral solution for treating coronary heart diseases and preparation method of traditional Chinese medicine oral solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105194298A true CN105194298A (en) | 2015-12-30 |
Family
ID=54942483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510759264.XA Pending CN105194298A (en) | 2015-11-10 | 2015-11-10 | Traditional Chinese medicine oral solution for treating coronary heart diseases and preparation method of traditional Chinese medicine oral solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105194298A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963509A (en) * | 2016-05-10 | 2016-09-28 | 青岛市第三人民医院 | Traditional Chinese medicinal dropping pill preparation for treating myocardial ischemia |
| CN110627036A (en) * | 2018-06-22 | 2019-12-31 | 北京中医药大学 | Preparation and application of dragon bone carbon quantum dots (nano particles/nano particles) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1970069A (en) * | 2006-12-26 | 2007-05-30 | 曹国胜 | Chinese medicinal pill for treating coronary heart disease |
| CN102631542A (en) * | 2011-02-15 | 2012-08-15 | 李明哲 | Chinese medicament for treating coronary heart disease and preparation method thereof |
-
2015
- 2015-11-10 CN CN201510759264.XA patent/CN105194298A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1970069A (en) * | 2006-12-26 | 2007-05-30 | 曹国胜 | Chinese medicinal pill for treating coronary heart disease |
| CN102631542A (en) * | 2011-02-15 | 2012-08-15 | 李明哲 | Chinese medicament for treating coronary heart disease and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 凌沛学: "《中药学概论》", 31 August 2007, 中国轻工业出版社 * |
| 刘会忠等: "辨证分型治疗冠心病532例", 《中国中医药现代远程教育》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963509A (en) * | 2016-05-10 | 2016-09-28 | 青岛市第三人民医院 | Traditional Chinese medicinal dropping pill preparation for treating myocardial ischemia |
| CN110627036A (en) * | 2018-06-22 | 2019-12-31 | 北京中医药大学 | Preparation and application of dragon bone carbon quantum dots (nano particles/nano particles) |
| CN110627036B (en) * | 2018-06-22 | 2021-12-17 | 北京中医药大学 | Preparation and application of dragon bone carbon quantum dots (nano particles/nano particles) |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104983818A (en) | Traditional Chinese medicine for treating gynecologic diseases, and preparation method thereof | |
| CN102579708B (en) | Chinese medicinal formula for tonifying yang and reinforcing kidney, liver and lung | |
| CN107029182A (en) | One kind treats infertile Chinese medicine and preparation method | |
| CN103977217A (en) | Medicinal composition for treating renal carcinoma | |
| CN102058870A (en) | Medicine for treating rheumatism, rheumatoid arthritis and stroke hemiplegia and preparation method thereof | |
| CN103142895B (en) | Kidney nourishing mixture and preparation method thereof | |
| CN103285279B (en) | Traditional Chinese medicine composition for promoting gravid postpartum recovery, and applications thereof | |
| CN102988639B (en) | Medicament for treating cervical spondylosis and preparation method of medicament | |
| CN102988939B (en) | Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method thereof | |
| CN103877512A (en) | Traditional Chinese medicine for treating arrhythmia and preparation method thereof | |
| CN103919910A (en) | Medicine for treating coronary heart disease | |
| CN105194298A (en) | Traditional Chinese medicine oral solution for treating coronary heart diseases and preparation method of traditional Chinese medicine oral solution | |
| CN105232955A (en) | Traditional Chinese medicine composition capable of tonifying kidneys and preparation method thereof | |
| CN102526581B (en) | Chinese medicinal composition for treating hypertension diseases | |
| CN102988938A (en) | Traditional Chinese medicine composition for treating arrhythmia or atrial fibrillation and preparation method thereof | |
| CN104042930A (en) | Traditional Chinese medicine composition for nourishing blood and tonifying kidney | |
| CN104257813B (en) | A kind of Chinese medicine composition of QI and blood regulating and preparation method thereof | |
| CN103182035B (en) | Traditional Chinese medicine composition used for treating chronic arrhythmia of elderly people and preparation method of traditional Chinese medicine composition | |
| CN106266427A (en) | A kind of Traditional Chinese medicinal liquor treating nephropathy and preparation method thereof | |
| CN104998241A (en) | Astragalus membranaceus qi-tonifying traditional Chinese medicine liquor | |
| CN104606537A (en) | Qi-reinforcing and blood-nourishing medicated diet for improving chemotherapy-induced myocardial ischemic injury and preparation method | |
| CN105194181A (en) | Traditional Chinese medicine oral solution for treating lumbar hyperosteogeny and preparation method thereof | |
| CN105250618A (en) | Antiviral traditional Chinese medicine composition for treating liver cirrhosis and preparation method thereof | |
| CN105213890A (en) | A kind of Chinese medicine oral liquid and preparation method for the treatment of spontaneous perspiration hyperhidrosis | |
| CN103933296A (en) | Traditional Chinese medicine for treating chromic glomerulonephritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151230 |
|
| WD01 | Invention patent application deemed withdrawn after publication |