CN102988939B - Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating impotence and premature ejaculation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating impotence and premature ejaculation and a preparation method thereof. The traditional Chinese medicine composition comprises 25-45 parts of radix aconiti carmichaeli, 20-40 parts of herba epimedii, 20-40 parts of rehmannia glutinosa, 15-30 parts of semen cuscutae, 15-30 parts of herb of savatier monochasma, 15-30 parts of medlar, 15-30 parts of ramulus cinnamomi, 15-30 parts of Chinese pholidota herb, 10-22 parts of radix paeoniae alba, 10-22 parts of astragalus mongholicus, 10-22 parts of angelica sinensis, 6-18 parts of Chinese dates, 8-18 parts of Chinese chive seeds, 8-18 parts of ovum of mantis, 6-15 parts of Korean ginseng, 4-12 parts of gingers and 2-10 parts of honey-fried licorice root. The traditional Chinese medicine composition can be prepared to be any clinically available medicinal preparation according to the traditional Chinese medicine conventional preparation method, has the efficacies of warming liver and kidney, tonifying yang and controlling nocturnal emission, and reinforcing qi and nourishing blood, has an accurate and reliable curative effect on the treatment of impotence and premature ejaculation through the demonstration of the clinical curative effect, can be used for treating both manifestation and root cause of disease, is safe in clinical application and does not have any toxic and side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of impotence and premature ejaculation and preparation method thereof, belong to the treatment by Chinese herbs field of impotence and premature ejaculation.
Background technology
Sexual impotence and erection disturbance, refer to that, when attempting sexual intercourse, penis erecting strength is not enough to insert vagina, or penis erecting strength is held time and has been not enough to satisfied sexual life.The sickness rate of sexual impotence accounts for about 50% of adult male.Male sexual disorder comprises hyposexuality, erection disturbance, orgasm and Ejaculatory dysfunction, the weak dysfunction of penis, and wherein erection disturbance is the most common male sexual disorder.
Premature ejaculation refers to that ejaculation occurs in before penis enters vagina, or it is shorter to enter the time in vagina, not yet comes to orgasm in women, and ejaculation ahead of time and the sexual intercourse that occurs are discord obstacle.The diagnostic criteria of premature ejaculation is whether the wife's side meets.Type be divided into organic (mainly containing the diseases such as prostatitis to cause) and non-organic (psychological, habitual, and the too fast phenomenon of ejaculation to cause because of the normal reason such as redundant prepuce), cause the reason of premature ejaculation mainly can be divided into psychology and physiology two large divisions, from treatment angle, only treat premature ejaculation from psychology and physiology two sides simultaneously, could realize.
Premature ejaculation is the most common sexual dysfunction disease of male, has become one of disease the most common in Urology Surgery and andrology's clinic diagnosis all over the world.Redundant prepuce can cause premature ejaculation.Operating pressure is large, psychentonia, and sexual life is frequent, and masturbation excessively also can cause premature ejaculation.In addition, the glans penis of phimosis patient never chance leaks outside, naturally too responsive, and one touches and namely lets out, if treat not in time, also there will be premature ejaculation.The clinical manifestation of premature ejaculation is mainly ejaculated too fast.The Therapeutic Method of premature ejaculation is varied at home, comprises various Drug therapy, surgical intervention, Psychology and behavior treatment and various folk therapy method.
At present, be used for the treatment of sexual impotence, Chinese patent medicine the also existing all in various degree of premature ejaculation takes effect slow, the defect such as curative effect is remarkable not, have much room for improvement.
Summary of the invention
Technical problem to be solved by this invention be overcome existing treatment sexual impotence, premature ejaculation medicine existing for take effect slow, curative effect not significantly, the defect such as toxic and side effects is large, the Chinese medicine composition of a kind of instant effect, determined curative effect, the treatment sexual impotence had no side effect, premature ejaculation is provided;
Another technical problem to be solved by this invention is to provide a kind of method preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for sexual impotence, premature ejaculation, comprise each component composition of following weight portion:
Radix Aconiti Lateralis Preparata 25-45 part, Herba Epimedii 20-40 part, Radix Rehmanniae Preparata 20-40 part, Semen Cuscutae 15-30 part, Herba monochasmatis 15-30 part, Fructus Lycii 15-30 part, Ramulus Cinnamomi 15-30 part, Pseudobulbus Pholidotae Chinensis 15-30 part, Radix Paeoniae Alba 10-22 part, Radix Astragali 10-22 part, Radix Angelicae Sinensis 10-22 part, Fructus Jujubae 6-18 part, leek seed 8-18 part, Ootheca Mantidis 8-18 part, Korean Ginseng 6-15 part, Rhizoma Zingiberis Recens 4-12 part and Radix Glycyrrhizae Preparata 2-10 part;
Preferably, the weight portion of each component is: Radix Aconiti Lateralis Preparata 25-40 part, Herba Epimedii 20-35 part, Radix Rehmanniae Preparata 20-30 part, Semen Cuscutae 15-25 part, Herba monochasmatis 15-25 part, Fructus Lycii 15-25 part, Ramulus Cinnamomi 15-25 part, Pseudobulbus Pholidotae Chinensis 15-25 part, Radix Paeoniae Alba 10-18 part, Radix Astragali 10-18 part, Radix Angelicae Sinensis 10-18 part, Fructus Jujubae 6-15 part, leek seed 8-15 part, Ootheca Mantidis 8-15 part, Korean Ginseng 6-12 part, Rhizoma Zingiberis Recens 4-9 part, Radix Glycyrrhizae Preparata 2-8 part;
Preferred, the weight portion of each component is: Radix Aconiti Lateralis Preparata 35 parts, Herba Epimedii 30 parts, 25 parts, Radix Rehmanniae Preparata, Semen Cuscutae 20 parts, Herba monochasmatis 20 parts, Fructus Lycii 20 parts, Ramulus Cinnamomi 20 parts, Pseudobulbus Pholidotae Chinensis 20 parts, Radix Paeoniae Alba 15 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, 12 parts, Fructus Jujubae, leek seed 12 parts, Ootheca Mantidis 10 parts, Korean Ginseng 10 parts, 7 parts, Rhizoma Zingiberis Recens, Radix Glycyrrhizae Preparata 5 parts.
Radix Aconiti Lateralis Preparata: the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Meridian distribution of property and flavor: pungent, sweet is warm greatly; Poisonous.GUIXIN, kidney, spleen channel.Function: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.
Radix Rehmanniae Preparata: Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), has another name called Radix Rehmanniae Preparata or throws oneself on the ground, forming through Processing methods.Usually with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant is through repeatedly steaming solarization, to inside and outside darkish complexion glossy, quality softness is sticky.Section use, or parch to black is used.There is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, diseases such as also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst.
Semen Cuscutae: the seed of dicotyledon scammonia section plant Semen Cuscutae, Cuscuta australis, cuscuta japonica Choisy etc., has effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, solid tire stopping leak.
Ramulus Cinnamomi: the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Cure mainly: expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Effect: diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.
Herba Epimedii: Berberidaceae plant Epimedium brevicornum, has very high medical value.Taste is returned through acrid, sweet, warm.Return liver, kidney channel cures mainly function: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Herba monochasmatis: be the dry herb of Scrophulariaceae (Scrophulariaceae) plant Herba monochasmatis.Bitter in the mouth, cool in nature.Function cures mainly: for cough, spits blood, bloody dysentery, leukorrhagia, gingivitis, mastitis, furuncle and phyma.
Pseudobulbus Pholidotae Chinensis: be herb or the pseudobulb of monocotyledon medicine the orchid family peach family plant seed Pseudobulbus Pholidotae Chinensis.Effect: nourishing the lung to arrest cough, silt releasing and analgesia.Cure mainly for pulmonary tuberculosis cough, cough with asthma QI rising in reverse order person.For the traumatic injury person of swelling and ache.
Radix Paeoniae Alba: be the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Leek seed: be the dry mature seed of liliaceous plant Folium Allii tuberosi Allium tuberosum Rottler.Property pungent, sweet, temperature.Return kidney, Liver Channel.Effect: temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs, warm waist knee joint.
Ootheca Mantidis: be the ootheca of Mantidae insecticide Chinese mantid, southern mantis, wide abdomen Mantidis, have another name called Ticks Octopus ocellatus Gray, Mulberry Octopus ocellatus Gray.Ancient times claims Mantidis ovum to be the egg capsule of a mantis, originates in person on mulberry and is then called Ootheca Mantidis.Ootheca Mantidis has controlling nocturnal emission with astringent drugs reducing urination, effect of reinforcing the kidney and supporting YANG.
Korean Ginseng: call Korean ginseng, directly do not join.The root of Araliaceae Radix Ginseng band rhizome, steams through processing and forms.Divide North Korea's Radix Ginseng Rubra and South Korea Radix Ginseng Rubra.Korean Ginseng can be divided into again water ginseng, Radix Ginseng and Radix Ginseng Rubra according to shape and color.Korean Ginseng has the effect such as strongly invigorating primordial QI, promoting the production of body fluid and inducing sedation of the mind, is applicable to the insomniac that palpitates with fear, body void person, heart failure, cardiogenic shock etc.
Radix Glycyrrhizae Preparata: Radix Glycyrrhizae Preparata is the Radix Glycyrrhizae of smoking with honey.
Chinese medicine composition of the present invention is based on the pathogenetic research of the deep layer of inventor to impotence and premature ejaculation and Therapeutic Principle thereof, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, filter out the crude drug of temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs, benefiting QI and nourishing blood, form according to certain weight proportion prescription.
When adding the raw material of following weight portion in the present invention in drug composition further, for sexual impotence, there is better therapeutic efficiency: Actinolitum 10-22 part, Herba Cistanches 10-22 part, Herba Cynomorii 8-20 part, Cortex Eucommiae 8-20 part, Radix Dipsaci 8-20 part, Stalactitum 4-15 part, Placenta Hominis 3-12 part; Preferably, the weight portion of each crude drug is: Actinolitum 18 parts, Herba Cistanches 18 parts, Herba Cynomorii 12 parts, the Cortex Eucommiae 12 parts, Radix Dipsaci 12 parts, Stalactitum 8 parts, Placenta Hominis 6 parts.
Actinolitum: Actinolitum is silicates mineral, it is a member in amphibole series, and this kind of mineral are often called as amphibole asbesto.Actinolitic crystal is long column shape, needle-like or hair sample.Chemical formula is Ca
2(Mg, Fe
22)
5(Si
8o
22) (OH)
2, crystal belongs to monoclinic double chain silicate mineral.It is the essential mineral of composition nephrite.Actinolitum is thought warm in nature salty by the traditional Chinese medical science, has effect of warming the kidney to invigorate YANG, is used for treating sexual impotence, seminal emission, the symptoms such as premature ejaculation.
Herba Cynomorii: the dry meat stem of Cynomoriaceae plant Herba Cynomorii Cynomorium songaricum Rupr..Have another name called Herba Cynomorii, a kind of parasitic plant, medicine another name ground ball top, rust iron staff, Songaria Cynomorium Herb, wild in desert and Gobi, subzero 20 DEG C of growths are the most suitable, grow part not accumulated snow, do not freeze.There is the kidney invigorating intestine moistening, control sexual impotence, the effects such as hematuria.
Stalactitum (stalactite): also known as stalactite, refers to the general name of the different shape lime deposit such as stalactite, stalagmite, stone column formed in very long earth history and under specific geological conditions in cave, carbonate rock area; For carbonate mineral calcite race calcite, main containing calcium carbonate (CaCO3).After gathering, except roguing stone, clean, dry.Warming the lung, supporing yang, relieving asthma, antacid.Breath with cough for cold-phlegm, yang deficiency is cold breathes heavily, chills and pain of the waist and kness, stomachache pantothenic acid, galactostasis.
Placenta Hominis: the Placenta Hominis referring to the mankind, the traditional Chinese medical science is thought, Placenta Hominis nature and flavor are sweet, salty, warm, enters lung, the heart, kidney channel, has the kidney invigorating and essence nourishing, the merit of benefiting QI and nourishing blood.
When adding the raw material of following weight portion in the present invention in drug composition further, for seminal emission, there is better therapeutic efficiency: Fructus Corni 10-22 part, Os Draconis 4-12 part, Concha Ostreae 10-22 part, Fructus Rosae Laevigatae 8-18 part, Fructus Schisandrae Chinensis 8-18 part; Preferably, the weight portion of each crude drug is: Fructus Corni 18 parts, Os Draconis 8 parts, Concha Ostreae 15 parts, Fructus Rosae Laevigatae 12 parts, Fructus Schisandrae Chinensis 12 parts.
Fructus Corni: the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb.et Zucc..Liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapse hidroschesis in addition also have promoting the production of body fluid to quench thirst.
Os Draconis: for ancient times mammal as if the fossil of skeleton of class, rhinoceros class, Hippocampal cortex etc.Be distributed in Henan, Hebei, Shanxi, the Inner Mongol, Qinghai, Yunnan etc.Function cures mainly: tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, insomnia and dreamful sleep, spontaneous sweating, seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Fructus Rosae Laevigatae: the dry mature fruit of rosaceous plant Fructus Rosae Laevigatae Rosa laevigata Michx..There is effect of controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.
In side of the present invention, each medicine compatibility plays effect of temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs, benefiting QI and nourishing blood together altogether, Chinese medicine composition of the present invention is for impotence and premature ejaculation treating both the principal and secondary aspects of a disease, clinical observation on the therapeutic effect confirms, Chinese medicine composition of the present invention is reliable for impotence and premature ejaculation determined curative effect, true.Chinese medicine composition of the present invention is nontoxic, safe and reliable, has no adverse reaction after taking, Clinical practice safety.
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the suitable clinical preparation of any one is prepared into the method for Chinese medicinal of routine, as oral formulations or external preparation, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid, drop pill etc.; External preparation used can unguentum, washing liquid, liniment etc.
A kind of preparation method of Chinese medicine composition of the present invention: after being taken by described weight by each crude drug of the present invention, pulverize, sieve (can be such as 600-1000 mesh sieve), to obtain final product.Certainly, after also each crude drug can being pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared into capsule, tablet or pill.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as age, health status of concrete dosage form, patient.As guidance: usage and dosage: capsule, each capsule content 0.6 gram of crude drug, oral 1 to 3 at every turn, three times on the one 15 days is a course for the treatment of.
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment; these embodiments are only exemplary; what those skilled in the art should understand that is; can modify to the details of technical solution of the present invention and form lower without departing from the spirit and scope of the present invention or replace, but these amendments and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 25, Herba Epimedii 20, Radix Rehmanniae Preparata 20, Semen Cuscutae 15, Herba monochasmatis 15, Fructus Lycii 15, Ramulus Cinnamomi 15, Pseudobulbus Pholidotae Chinensis 15, Radix Paeoniae Alba 10, the Radix Astragali 10, Radix Angelicae Sinensis 10, Fructus Jujubae 6, leek seed 8, Ootheca Mantidis 8, Korean Ginseng 6, Rhizoma Zingiberis Recens 4, Radix Glycyrrhizae Preparata 2 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 2 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 45, Herba Epimedii 40, Radix Rehmanniae Preparata 40, Semen Cuscutae 30, Herba monochasmatis 30, Fructus Lycii 30, Ramulus Cinnamomi 30, Pseudobulbus Pholidotae Chinensis 30, Radix Paeoniae Alba 22, the Radix Astragali 22, Radix Angelicae Sinensis 22, Fructus Jujubae 18, leek seed 18, Ootheca Mantidis 18, Korean Ginseng 15, Rhizoma Zingiberis Recens 12, Radix Glycyrrhizae Preparata 10 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 3 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 35, Herba Epimedii 30, Radix Rehmanniae Preparata 25, Semen Cuscutae 20, Herba monochasmatis 20, Fructus Lycii 20, Ramulus Cinnamomi 20, Pseudobulbus Pholidotae Chinensis 20, Radix Paeoniae Alba 15, the Radix Astragali 15, Radix Angelicae Sinensis 15, Fructus Jujubae 12, leek seed 12, Ootheca Mantidis 10, Korean Ginseng 10, Rhizoma Zingiberis Recens 7, Radix Glycyrrhizae Preparata 5 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 4 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 25, Herba Epimedii 20, Radix Rehmanniae Preparata 20, Semen Cuscutae 15, Herba monochasmatis 15, Fructus Lycii 15, Ramulus Cinnamomi 15, Pseudobulbus Pholidotae Chinensis 15, Radix Paeoniae Alba 10, the Radix Astragali 10, Radix Angelicae Sinensis 10, Fructus Jujubae 6, leek seed 8, Ootheca Mantidis 8, Korean Ginseng 6, Rhizoma Zingiberis Recens 4, Radix Glycyrrhizae Preparata 2, Actinolitum 10, Herba Cistanches 10, Herba Cynomorii 8, the Cortex Eucommiae 8, Radix Dipsaci 8, Stalactitum 4, Placenta Hominis 3 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 5 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 45, Herba Epimedii 40, Radix Rehmanniae Preparata 40, Semen Cuscutae 30, Herba monochasmatis 30, Fructus Lycii 30, Ramulus Cinnamomi 30, Pseudobulbus Pholidotae Chinensis 30, Radix Paeoniae Alba 22, the Radix Astragali 22, Radix Angelicae Sinensis 22, Fructus Jujubae 18, leek seed 18, Ootheca Mantidis 18, Korean Ginseng 15, Rhizoma Zingiberis Recens 12, Radix Glycyrrhizae Preparata 10, Actinolitum 22, Herba Cistanches 22, Herba Cynomorii 20, the Cortex Eucommiae 20, Radix Dipsaci 20, Stalactitum 15, Placenta Hominis 12 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 6 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 35, Herba Epimedii 30, Radix Rehmanniae Preparata 25, Semen Cuscutae 20, Herba monochasmatis 20, Fructus Lycii 20, Ramulus Cinnamomi 20, Pseudobulbus Pholidotae Chinensis 20, Radix Paeoniae Alba 15, the Radix Astragali 15, Radix Angelicae Sinensis 15, Fructus Jujubae 12, leek seed 12, Ootheca Mantidis 10, Korean Ginseng 10, Rhizoma Zingiberis Recens 7, Radix Glycyrrhizae Preparata 5, Actinolitum 18, Herba Cistanches 18, Herba Cynomorii 12, the Cortex Eucommiae 12, Radix Dipsaci 12, Stalactitum 8, Placenta Hominis 6 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 7 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 25, Herba Epimedii 20, Radix Rehmanniae Preparata 20, Semen Cuscutae 15, Herba monochasmatis 15, Fructus Lycii 15, Ramulus Cinnamomi 15, Pseudobulbus Pholidotae Chinensis 15, Radix Paeoniae Alba 10, the Radix Astragali 10, Radix Angelicae Sinensis 10, Fructus Jujubae 6, leek seed 8, Ootheca Mantidis 8, Korean Ginseng 6, Rhizoma Zingiberis Recens 4, Radix Glycyrrhizae Preparata 2, Fructus Corni 10, Os Draconis 4, Concha Ostreae 10, Fructus Rosae Laevigatae 8, Fructus Schisandrae Chinensis 8 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 8 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 45, Herba Epimedii 40, Radix Rehmanniae Preparata 40, Semen Cuscutae 30, Herba monochasmatis 30, Fructus Lycii 30, Ramulus Cinnamomi 30, Pseudobulbus Pholidotae Chinensis 30, Radix Paeoniae Alba 22, the Radix Astragali 22, Radix Angelicae Sinensis 22, Fructus Jujubae 18, leek seed 18, Ootheca Mantidis 18, Korean Ginseng 15, Rhizoma Zingiberis Recens 12, Radix Glycyrrhizae Preparata 10, Fructus Corni 22, Os Draconis 12, Concha Ostreae 22, Fructus Rosae Laevigatae 18, Fructus Schisandrae Chinensis 18 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 9 capsule
Each crude drug (unit: g): Radix Aconiti Lateralis Preparata 35, Herba Epimedii 30, Radix Rehmanniae Preparata 25, Semen Cuscutae 20, Herba monochasmatis 20, Fructus Lycii 20, Ramulus Cinnamomi 20, Pseudobulbus Pholidotae Chinensis 20, Radix Paeoniae Alba 15, the Radix Astragali 15, Radix Angelicae Sinensis 15, Fructus Jujubae 12, leek seed 12, Ootheca Mantidis 10, Korean Ginseng 10, Rhizoma Zingiberis Recens 7, Radix Glycyrrhizae Preparata 5, Fructus Corni 18, Os Draconis 8, Concha Ostreae 15, Fructus Rosae Laevigatae 12, Fructus Schisandrae Chinensis 12 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating impotence and premature ejaculation of the present invention
One, physical data: 168 routine patients all meet the clinical criteria of impotence and premature ejaculation, 22 years old ~ 54 years old age, average 37 years old.Patient is divided into three groups at random, often organizes 56 examples; Three groups of no significant differences on age, the course of disease and coincident with severity degree of condition.
Two, trial drug
Capsule prepared by embodiment of the present invention 1-9.
Three, Therapeutic Method
168 routine patients are divided into 3 groups at random, that is: test 1 group, test 2 groups and test 3 groups, often organize each 56 examples, test 1 group and adopt the capsule prepared by embodiment 1-3 to treat, test the capsule treatment of 2 groups of employings prepared by embodiment 4-6; Testing 3 groups adopts the capsule prepared by embodiment 7-9 to treat; Oral, one time 3 (0.6g crude drug/grain), 3 times on the one 15 days is a course for the treatment of, treats 2 courses for the treatment of altogether; Period in a medicine withdraws other related drugs and other treatment.
Four, efficacy assessment standard
Efficacy assessment standard and foundation: criterion of therapeutical effect: treat and forward and backward objective scoring is carried out to patients symptomatic and sign.Clinical symptoms and sign are undertaken by 4 grades of point systems, and 0=is slight without, 1=, 2=moderate, 3=severe.Fully recover for integrated value reduces > 95%, effective is integrated value > 60%, transfers well integrated value to and reduces 20% ~ 60%, and invalid is integrated value minimizing < 20%.Integrated value: total mark × 100% before (before treatment the rear integration of integration-treatment)/treatment.
Five, clinical observation result
Clinical observation result is in table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating impotence and premature ejaculation of the present invention
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for impotence and premature ejaculation patient; Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (5)
1. treat the Chinese medicine composition of impotence and premature ejaculation for one kind, it is characterized in that, be made up of each crude drug of following weight portion: Radix Aconiti Lateralis Preparata 25-45 part, Herba Epimedii 20-40 part, Radix Rehmanniae Preparata 20-40 part, Semen Cuscutae 15-30 part, Herba monochasmatis 15-30 part, Fructus Lycii 15-30 part, Ramulus Cinnamomi 15-30 part, Pseudobulbus Pholidotae Chinensis 15-30 part, Radix Paeoniae Alba 10-22 part, Radix Astragali 10-22 part, Radix Angelicae Sinensis 10-22 part, Fructus Jujubae 6-18 part, leek seed 8-18 part, Ootheca Mantidis 8-18 part, Korean Ginseng 6-15 part, Rhizoma Zingiberis Recens 4-12 part, Radix Glycyrrhizae Preparata 2-10 part, Fructus Corni 10-22 part, Os Draconis 4-12 part, Concha Ostreae 10-22 part, Fructus Rosae Laevigatae 8-18 part and Fructus Schisandrae Chinensis 8-18 part.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each crude drug is: Radix Aconiti Lateralis Preparata 35 parts, Herba Epimedii 30 parts, 25 parts, Radix Rehmanniae Preparata, Semen Cuscutae 20 parts, Herba monochasmatis 20 parts, Fructus Lycii 20 parts, Ramulus Cinnamomi 20 parts, Pseudobulbus Pholidotae Chinensis 20 parts, Radix Paeoniae Alba 15 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, 12 parts, Fructus Jujubae, leek seed 12 parts, Ootheca Mantidis 10 parts, Korean Ginseng 10 parts, 7 parts, Rhizoma Zingiberis Recens, Radix Glycyrrhizae Preparata 5 parts, Fructus Corni 18 parts, Os Draconis 8 parts, Concha Ostreae 15 parts, Fructus Rosae Laevigatae 12 parts, Fructus Schisandrae Chinensis 12 parts.
3. prepare a method for Chinese medicine composition described in claim 1 or 2, comprise the following steps:
(1), each crude drug is taken by described weight proportion;
(2), by each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
4. the purposes of Chinese medicine composition described in claim 1 or 2 in preparation treatment sexual impotence medicine.
5. the purposes of Chinese medicine composition described in claim 1 or 2 in preparation treatment premature ejaculation medicine.
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