CN103550284A - Traditional Chinese medicine composition for treating urinary calculus and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating urinary calculus and preparation method thereof Download PDFInfo
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- CN103550284A CN103550284A CN201310513780.5A CN201310513780A CN103550284A CN 103550284 A CN103550284 A CN 103550284A CN 201310513780 A CN201310513780 A CN 201310513780A CN 103550284 A CN103550284 A CN 103550284A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating urinary calculus and a preparation method thereof. The traditional Chinese medicine composition for treating urinary calculus comprises 20-50 parts of kiwi, 20-50 parts of smooth hawksbeard, 20-50 parts of Balanophora polyandra Griff, 20-50 parts of silverfish, 15-35 parts of emilia sonchifolia and 15-35 parts of Lespedeza bicolor. The traditional Chinese medicine composition can be prepared into any clinically-acceptable oral pharmaceutical preparation by a traditional Chinese medicine conventional preparation method. The traditional Chinese medicine composition has the effects of clearing heat, eliminating dampness, inducing diuresis for treating stranguria and removing urinary calculus; and the clinical curative effect indicates that the traditional Chinese medicine composition has definite and reliable curative effect on urinary calculus, can treat both the symptoms and root causes, and has the advantages of high clinical application safety and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of urinary system calculus and preparation method thereof, belong to the treatment by Chinese herbs field of urinary system calculus.
Background technology
Urinary system calculus is the calculus occurring at the kidney of human body urinary system, ureter, bladder, urethra, also claims urinary calculus, is that the sickness rate of global commonly encountered diseases ， China is also higher.Its clinical symptoms reaction can be pain, hematuria, frequent micturition, urgent micturition, generates heat, shivers, and patient is very painful, if treatment not in time, also can threat to life.
Urinary system calculus belongs to the category of Chinese medicine " stranguria caused by urinary stone ", how because of part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels accumulated heat, decocts due to water liquid.< < General Treatise on the Cause and Symptoms of Diseases stranguria caused by urinary stone is waited > >: " stranguria caused by urinary stone person is drenched and gone out stone also.The main water of kidney, water knot turns to stone, therefore kidney visitor sandstone.Suffer from a deficiency of the kidney and taken advantage of by heat, heat becomes to drench.The shape of its disease, urine is pain in stem, urine can not finally go out, pain extending to the lower abdomen, bladder pain in the abdomen, sandstone are said from urine, very person fill in pain close vexed absolutely." control should be clear in accumulated heat, wash its sandstone.
At present, the Chinese patent medicine that is used for the treatment of urinary system calculus all in various degree exist slow, the defect such as curative effect is remarkable not that takes effect, have much room for improvement.
Summary of the invention
That technical problem to be solved by this invention is that overcome existing treatment urinary system calculus existing takes effect is slow, curative effect not significantly, the defect such as toxic and side effects is large, the Chinese medicine composition of the treatment urinary system calculus that provide a kind of instant effect, determined curative effect, has no side effect;
Another technical problem to be solved by this invention is to provide a kind of method of preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for urinary system calculus, comprise that each component of following weight portion forms: Fructus Averrhoae Carambolae, Herba youngiae japonicae, Herba Balanophorae polyandrae, lepismae saccharinae, Herba Emiliae and Caulis Seu Folium Lespedezae Bicoloris.
Preferably, the weight portion of each component is: Fructus Averrhoae Carambolae 20-50 part, Herba youngiae japonicae 20-50 part, Herba Balanophorae polyandrae 20-50 part, lepismae saccharinae 20-50 part, Herba Emiliae 15-35 part, Caulis Seu Folium Lespedezae Bicoloris 15-35 part.
Preferred, the weight portion of each component is: Fructus Averrhoae Carambolae 25-45 part, Herba youngiae japonicae 25-45 part, Herba Balanophorae polyandrae 25-45 part, lepismae saccharinae 25-45 part, Herba Emiliae 20-30 part, Caulis Seu Folium Lespedezae Bicoloris 20-30 part.
Most preferred, the weight portion of each component is: 35 parts of Fructus Averrhoae Carambolaes, 35 parts of Herba youngiae japonicae, 35 parts of Herba Balanophorae polyandraes, 35 parts of lepismae saccharinaees, 25 parts of Herba Emiliae, 25 parts of Caulis Seu Folium Lespedezae Bicoloris.
Fructus Averrhoae Carambolae: be the fruit of Oxalidaceae plant Fructus Averrhoae Carambolae.Nature and flavor: cold in nature, sweet in the mouth acid.Return lung, the heart, small intestine meridian.Function cures mainly: clearing away heat and promoting production of body fluid, promoting diuresis to remove toxic substance, the therapeutic method to keep the adverse QI flowing downwards and in, inducing diuresis for treating stranguria syndrome.Control cough due to pathogenic wind-heat, pharyngalgia, excessive thirst, stranguria caused by urinary stone, erosion of the oral mucosa, toothache, malaria with splenomegaly, the diseases such as urinary obstruction.
Herba youngiae japonicae: be herb or the root of feverfew Herba youngiae japonicae.Nature and flavor: sweet, micro-hardship, cool.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, pain relieving.For pharyngitis, mastitis, toothache, dysuria, cirrhotic ascites; Furuncle toxic swelling is controlled in external.
Herba Balanophorae polyandrae: be the Herb of Balanophoraceae plant Herba Balanophorae polyandrae.Gather: gather autumn.Function cures mainly: enriching yin and nourishing kidney.Control blood deficiency, hemorrhage, gonorrhea.
Lepismae saccharinae: be the Scorpio of Lepismatidae insecticide.Nature and flavor: salty, temperature.Gui Jing: < < book on Chinese herbal medicine is asked former > >: " enter small intestinal, bladder, liver." function cures mainly: diuresis, treating stranguria, dispel the wind, removing toxic substances.Control gonorrhea, dysuria, pediatric epilepsy scared, furuncle, corneal nebula.
Herba Emiliae: be herb or the whole herb with root of feverfew Herba Duchesneae Indicae.Nature and flavor: hardship, cool.Function cures mainly: heat clearing away, diuretic, removing heat from blood, removing toxic substances.Control dysentery, diarrhoea, have blood in stool, edema, acute appendicitis, engages ear, order also, throat moth, furuncle, toxic swelling.
Caulis Seu Folium Lespedezae Bicoloris: be root or the root bark of leguminous plant Caulis Seu Folium Lespedezae Bicoloris.Nature and flavor: sweet, flat.Function cures mainly: moistening lung and clearing heat, relieving stranguria by diuresis.Control cough due to lung-heat, pertussis, epistaxis, gonorrhea.
Chinese medicine composition of the present invention is to the pathogenetic research of the deep layer of urinary system calculus and Therapeutic Principle thereof based on inventor, simultaneously according to inventor clinical experience and pharmaceutical research achievement for many years, filter out clearing heat and expelling damp, inducing diuresis for treating stranguria syndrome, fossil calculus removing crude drug, forms according to certain weight proportion prescription.
The effect while further adding the raw material of following weight portion in above-mentioned Chinese medicine composition with better treatment urinary system calculus: Herba Equiseti Arvinsis 5-15 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 5-15 part, Radix Mirabilis 4-10 part, Caulis Panici miliacei 3-8 part; Preferably, the consumption of each component is: 8 parts of Herba Equiseti Arvinsiss, 8 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s, 6 parts of Radix Mirabiliss, 4 parts of Caulis Panici miliacei.
Herba Equiseti Arvinsis: be the herb of Equisetaceae plant Herba Equiseti Arvinsis.Nature and flavor: hardship, cool.Function cures mainly: heat clearing away, removing heat from blood, cough-relieving, diuresis.Control haematemesis, epistaxis, has blood in stool, vicarious menstruation, cough and asthma, gonorrhea.
Radix achyranthis asperae (Herba Achyranthis Asperae): be the herb of amaranthaceous plant coarse wool Radix Achyranthis Bidentatae.Nature and flavor: toil, cold.Function cures mainly: heat clearing away, induce sweat, and diuretic, invigorates blood circulation.The heating that cures cold, dysentery, malaria, laryngalgia, beriberi, gonorrhea.Edema, traumatic injury.
Radix Mirabilis: be the tuber of Nyctaginaceae plant Mirabilis jalapa.Nature and flavor: sweetness and bitterness, flat.Function cures mainly: diuresis, purge heat, and promoting blood circulation to remove blood stasis.Control stranguria with turbid discharge, leukorrhagia, impairment of the lung caused by overstrain is spitted blood, carbuncle carbuncle on the back, acute arthritis.
Caulis Panici miliacei: be the stem of grass broomcorn millet.Nature and flavor: < < detailed outline > >: pungent, hot, slightly poisonous.Function cures mainly: control dysuria, edema, hematuria during pregnancy.
In side of the present invention, each medicine compatibility is played clearing heat and expelling damp together altogether, inducing diuresis for treating stranguria syndrome, the effect of fossil calculus, Chinese medicine composition of the present invention is for urinary system calculus treating both the principal and secondary aspects of a disease, clinical observation on the therapeutic effect confirmation, Chinese medicine composition of the present invention is reliable, true for urinary system calculus determined curative effect.Chinese medicine composition of the present invention is nontoxic, safe and reliable, after taking, has no adverse reaction, clinical use safety.
The present invention's each taste crude drug used can be bought and obtain at pharmacy.
Medicine activity component of the present invention can add various adjuvants required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., with conventional method of Chinese medicinal, be prepared into any suitable clinical oral administration preparation, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid, drop pill etc.
A kind of preparation method of Chinese medicine composition of the present invention: after each crude drug of the present invention is taken by described weight portion proportioning, pulverize, sieve (can be for example 80-200 mesh sieve), obtains.Certainly, after also each crude drug can being pulverized, add the required adjuvant of preparations shaping or excipient, according to conventional method, be prepared into capsule, tablet or pill.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; Each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, and preparations shaping, obtains.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factors such as concrete dosage form, patient's age, health status.As guidance: usage and dosage: capsule, 0.4 gram of crude drug of each capsule content, each oral 1 to 3,2 times on the one 10 days is a course for the treatment of.
The specific embodiment
Below in conjunction with specific embodiment, further describe the present invention; these embodiment are only exemplary; what those skilled in the art should understand that is; lower without departing from the spirit and scope of the present invention, can the details of technical solution of the present invention and form modified or be replaced, but these modifications and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
By following weight, take each crude drug (unit: g): Fructus Averrhoae Carambolae 20, Herba youngiae japonicae 20, Herba Balanophorae polyandrae 20, lepismae saccharinae 20, Herba Emiliae 15, Caulis Seu Folium Lespedezae Bicoloris 15; Above-mentioned each crude drug is decocted with water to secondary, add for the first time 4 times of weight of water, decoct 2 hours, add for the second time 5 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 2 capsules
By following weight, take each crude drug (unit: g): Fructus Averrhoae Carambolae 50, Herba youngiae japonicae 50, Herba Balanophorae polyandrae 50, lepismae saccharinae 50, Herba Emiliae 35, Caulis Seu Folium Lespedezae Bicoloris 35; Above-mentioned each crude drug is decocted with water to secondary, add for the first time 6 times of weight of water, decoct 2 hours, add for the second time 4 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 3 capsules
By following weight, take each crude drug (unit: g): Fructus Averrhoae Carambolae 35, Herba youngiae japonicae 35, Herba Balanophorae polyandrae 35, lepismae saccharinae 35, Herba Emiliae 25, Caulis Seu Folium Lespedezae Bicoloris 25; Above-mentioned each crude drug is decocted with water to secondary, add for the first time 4 times of weight of water, decoct 2 hours, add for the second time 5 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.30-1.35(55 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 4 capsules
By following weight, take each crude drug (unit: g): Fructus Averrhoae Carambolae 20, Herba youngiae japonicae 20, Herba Balanophorae polyandrae 20, lepismae saccharinae 20, Herba Emiliae 15, Caulis Seu Folium Lespedezae Bicoloris 15, Herba Equiseti Arvinsis 5, Radix achyranthis asperae (Herba Achyranthis Asperae) 5, Radix Mirabilis 4, Caulis Panici miliacei 3; Above-mentioned each crude drug is decocted with water to secondary, add for the first time 4 times of weight of water, decoct 2 hours, add for the second time 5 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.30-1.35(55 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 5 capsules
By following weight, take each crude drug (unit: g): Fructus Averrhoae Carambolae 50, Herba youngiae japonicae 50, Herba Balanophorae polyandrae 50, lepismae saccharinae 50, Herba Emiliae 35, Caulis Seu Folium Lespedezae Bicoloris 35, Herba Equiseti Arvinsis 15, Radix achyranthis asperae (Herba Achyranthis Asperae) 15, Radix Mirabilis 10, Caulis Panici miliacei 8; Above-mentioned each crude drug is decocted with water to secondary, add for the first time 6 times of weight of water, decoct 2 hours, add for the second time 4 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 6 capsules
By following weight, take each crude drug (unit: g): Fructus Averrhoae Carambolae 35, Herba youngiae japonicae 35, Herba Balanophorae polyandrae 35, lepismae saccharinae 35, Herba Emiliae 25, Caulis Seu Folium Lespedezae Bicoloris 25, Herba Equiseti Arvinsis 8, Radix achyranthis asperae (Herba Achyranthis Asperae) 8, Radix Mirabilis 6, Caulis Panici miliacei 4; Above-mentioned each crude drug is decocted with water to secondary, add for the first time 6 times of weight of water, decoct 2 hours, add for the second time 4 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating urinary system calculus of the present invention
One, physical data: 120 routine patients all meet the clinical criteria of urinary system calculus, is divided into 2 groups at random by patient, every group of 60 examples; 2 groups of no significant difference differences on sex, age, the course of disease and coincident with severity degree of condition.
Two, trial drug
The medicine that embodiment of the present invention 1-6 is prepared.
Three, Therapeutic Method
120 patients are divided into respectively to 2 groups at random, that is: test 2 groups of 1 group and tests, every group of each 60 examples, test 1 group and adopt the prepared capsule treatment of embodiment 1-3, test 2 groups and adopt the prepared capsules treatment of embodiment 4-6; Oral, one time 3 (0.4g crude drug/grain), 2 times on the one 10 days is a course for the treatment of, treats altogether 4 courses for the treatment of; Period in a medicine is withdrawn other related drugs and other treatment.
Four, efficacy assessment standard
Cure: clinical symptoms, sign disappear, and calculus is discharged;
Effective: clinical symptoms, sign disappear, but calculus is not discharged or part calculus excretes;
Effective: clinical symptoms, sign make moderate progress, and calculus is dwindled;
Invalid: clinical symptoms, sign have no variation, calculus is also unchanged.
Five, clinical observation result
Clinical observation result is in Table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating urinary system calculus of the present invention
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for Patients with Urinary Stone, and wherein, the curative effect of testing 2 groups will be better than testing the curative effect of 1 group significantly.Safety observe to be found, does not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (8)
1. a Chinese medicine composition for the treatment of urinary system calculus, is characterized in that, following component, consists of: Fructus Averrhoae Carambolae, Herba youngiae japonicae, Herba Balanophorae polyandrae, lepismae saccharinae, Herba Emiliae, Caulis Seu Folium Lespedezae Bicoloris.
2. according to Chinese medicine composition claimed in claim 1, it is characterized in that, the weight portion of each component is: Fructus Averrhoae Carambolae 20-50 part, Herba youngiae japonicae 20-50 part, Herba Balanophorae polyandrae 20-50 part, lepismae saccharinae 20-50 part, Herba Emiliae 15-35 part, Caulis Seu Folium Lespedezae Bicoloris 15-35 part.
3. according to Chinese medicine composition claimed in claim 2, it is characterized in that, the weight portion of each component is: Fructus Averrhoae Carambolae 25-45 part, Herba youngiae japonicae 25-45 part, Herba Balanophorae polyandrae 25-45 part, lepismae saccharinae 25-45 part, Herba Emiliae 20-30 part, Caulis Seu Folium Lespedezae Bicoloris 20-30 part.
4. according to Chinese medicine composition claimed in claim 3, it is characterized in that, the weight portion of each component is: 35 parts of Fructus Averrhoae Carambolaes, 35 parts of Herba youngiae japonicae, 35 parts of Herba Balanophorae polyandraes, 35 parts of lepismae saccharinaees, 25 parts of Herba Emiliae, 25 parts of Caulis Seu Folium Lespedezae Bicoloris.
5. treat a Chinese medicine composition for urinary system calculus, comprise that each component of following weight portion forms: Fructus Averrhoae Carambolae 20-50 part, Herba youngiae japonicae 20-50 part, Herba Balanophorae polyandrae 20-50 part, lepismae saccharinae 20-50 part, Herba Emiliae 15-35 part, Caulis Seu Folium Lespedezae Bicoloris 15-35 part, Herba Equiseti Arvinsis 5-15 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 5-15 part, Radix Mirabilis 4-10 part, Caulis Panici miliacei 3-8 part.
6. according to Chinese medicine composition claimed in claim 5, it is characterized in that, the weight portion of each component is: 35 parts of Fructus Averrhoae Carambolaes, 35 parts of Herba youngiae japonicae, 35 parts of Herba Balanophorae polyandraes, 35 parts of lepismae saccharinaees, 25 parts of Herba Emiliae, 25 parts of Caulis Seu Folium Lespedezae Bicoloris, 8 parts of Herba Equiseti Arvinsiss, 8 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s, 6 parts of Radix Mirabiliss, 4 parts of Caulis Panici miliacei.
7. a method of preparing claim 1-6 Chinese medicine composition described in any one, comprises the following steps:
(1) by described weight proportion, take each crude drug;
(2) each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, and preparations shaping, obtains.
8. claim 1-6 Chinese medicine composition purposes in preparation treatment urinary system calculus medicine described in any one.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267427A (en) * | 2015-12-01 | 2016-01-27 | 臧海阳 | Traditional Chinese medicine composition for treating lower-jiao damp-heat type urinary calculi |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829295A (en) * | 2010-05-01 | 2010-09-15 | 中山市中医院 | Preparation for treating urinary tract stones and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101829295A (en) * | 2010-05-01 | 2010-09-15 | 中山市中医院 | Preparation for treating urinary tract stones and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 汤祝捷: "泌尿系结石中医治疗进展", 《现代中西医结合杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105267427A (en) * | 2015-12-01 | 2016-01-27 | 臧海阳 | Traditional Chinese medicine composition for treating lower-jiao damp-heat type urinary calculi |
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Application publication date: 20140205 |