CN105250563A - Chinese herb preparation for treating pediatric intestinal parasites and preparing method thereof - Google Patents
Chinese herb preparation for treating pediatric intestinal parasites and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herb preparation for treating pediatric intestinal parasites and a preparing method thereof, and belongs to the technical field of traditional Chinese medicine. The Chinese herb preparation is prepared from portulaca oleracea, pumpkin seeds, areca-nuts, golden cypress, quispualis indica, rhizoma corydalis, fructus ulmi macrocarpae, Chinaberry roots, spina gleditsiae, cyrtomium fortunei, horseradish tree leaves and liquorice. The Chinese herb preparation is mainly used for infants suffering from an intestinal parasitic disease, has the effects of expelling water retention, relaxing the bowels, dissolving phlegm and retained fluid, killing parasites, removing stagnancy, relieving pain, arresting vomiting, improving appetite, invigorating stomach and tonifying spleen and has the advantages of being simple in preparation process, good in treatment effect, low in side effect, convenient to take, high in pertinency and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to one and treat parasitic Chinese medicine preparation of children intestinal and preparation method thereof.
Background technology
The disease that parasite causes at human body intestinal canal endoparasitism is referred to as intestinal parasitical diseases.Common are protozoon class and Vermes (comprising ascarid, ancylostome, pinworm, cestode, whipworm, ameba, giardia lamblia, infusorian etc.).The kind of Enterozoa is many, and complicated in people's endobiosis process, the pathological changes caused is not limited to intestinal.According to the immune state infecting parasitic kind and position and human body host, clinical symptoms and sign different.The factors such as most of intestinal parasitism and local sanitary condition, living habit, health perception, economic level and clustering of disease in family are relevant.
Infant modal intestinal parasitical diseases in period is ascariasis and enterobiasis.Absorb nutrition in the small intestinal that ascarid colonizes in people, cause children's to have no appetite, become thin, evening, sleep was ground one's teeth in sleep, and sometimes suffered from abdominal pain, and formed worm group when worm is many, can also block intestinal tube and form intestinal obstruction, cause violent stomachache, even can cause intestinal perforation.Ascarid pierces bile duct can cause ascariasis of biliary tract, and epigastrium angor is very harmful to infant growth.Pinworm is a kind of short and thin white nematicide, and about have a centimeter length, colonize in small intestinal lower end and large intestine, night of being everlasting is climbed out of by anus, and female worm lays eggs at anal area, thus causes anus very to itch, affects baby sleeping.
Present western medical treatment intestinal parasitical diseases has a lot of medicine and method, mainly adopt the method for parasite killing, but often the course of disease is longer for the patient of trouble intestinal parasitical diseases, cause very large infringement to health and digestive system, adopt western medical treatment can increase the weight of, to the infringement of patient body, also often to have side effect.Chinese medicine has its advantageous advantage controlling in worm, and it can on the basis of parasite killing, and conditioning nourishing digestive system, improve taste and digestive tract function, toxic and side effects is smaller.
Chinese patent application 201410774091.4 discloses the purposes of a kind of Chinese medicine preparation in preparation treatment Enterozoa medicine, the raw material of this Chinese medicine has the 18 taste medical materials such as Fructus Mume, Fructus Toosendan, Fructus Carpesii, Semen Arecae, Omphalia, Fructus Aurantii, Rhizoma Coptidis, Rhizoma Atractylodis, Herba Pogostemonis, Fructus Quisqualis, the Radix Aucklandiae, Semen Torreyae core, Rhizoma Zingiberis, Fructus Zanthoxyli, Radix Bupleuri, Fructus Crataegi, Spina Gleditsiae, Radix Glycyrrhizae, this Chinese medicine has the effect such as function of spleen and stomach regulating, the stagnant relieving distension of row, but specific aim is not strong, especially unstable to the parasitic therapeutic effect of children intestinal, not significantly.
Summary of the invention
The technical problem to be solved in the present invention is to provide one and treats parasitic Chinese medicine preparation of children intestinal and preparation method thereof, this Chinese medicine preparation has removing water retention by purgation relieving constipation, drink is washed in expectorant, parasite killing attacks long-pending, pain relieving preventing or arresting vomiting, increase effect of appetite and stomach invigorating strengthening the spleen, also have that preparation technology is simple, good effect, side effect be low, taking convenience and the advantage such as with strong points, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is:
One treats the parasitic Chinese medicine preparation of children intestinal, is prepared from by the raw material of following parts by weight: Herba Portulacae 2-20 part, Semen Cucurbitae 5-20 part, Semen Arecae 2-10 part, Cortex Phellodendri 2-12 part, Fructus Quisqualis 4-16 part, Rhizoma Corydalis 2-12 part, Fructus Ulmus preparatium 2-8 part, chinaberry root 2-8 part, Spina Gleditsiae 2-10 part, Rhizoma Osmundae 2-10 part, leaf of Moringa 2-8 part and Radix Glycyrrhizae 1-10 part.
Preferably, described Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 2 parts, Semen Cucurbitae 5 parts, Semen Arecae 2 parts, Cortex Phellodendri 2 parts, Fructus Quisqualis 4 parts, Rhizoma Corydalis 2 parts, Fructus Ulmus preparatium 2 parts, chinaberry root 2 parts, Spina Gleditsiae 2 parts, Rhizoma Osmundae 2 parts, leaf of Moringa 2 parts and 1 part, Radix Glycyrrhizae.
Preferably, described Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 20 parts, Semen Cucurbitae 20 parts, Semen Arecae 10 parts, Cortex Phellodendri 12 parts, Fructus Quisqualis 16 parts, Rhizoma Corydalis 12 parts, Fructus Ulmus preparatium 8 parts, chinaberry root 8 parts, Spina Gleditsiae 10 parts, Rhizoma Osmundae 10 parts, leaf of Moringa 8 parts and 10 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 12 parts, Semen Cucurbitae 10 parts, Semen Arecae 6 parts, Cortex Phellodendri 7 parts, Fructus Quisqualis 10 parts, Rhizoma Corydalis 7 parts, Fructus Ulmus preparatium 5 parts, chinaberry root 5 parts, Spina Gleditsiae 6 parts, Rhizoma Osmundae 6 parts, leaf of Moringa 5 parts and 6 parts, Radix Glycyrrhizae.
Further, described Chinese medicine preparation is oral formulations; Described oral formulations is tablet, capsule, granule, powder or oral liquid.
Accordingly, the preparation method of described Chinese medicine preparation comprises following step:
(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 60-80 mesh sieve, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 240-300W, and Extracting temperature is 40-60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;
(2): get Semen Cucurbitae, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, Fructus Ulmus preparatium, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, leaf of Moringa and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, surveys the extractum that relative density is 1.10-1.20 at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;
(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;
(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine preparation of the present invention.
Source, the nature and flavor of Chinese medicine preparation of the present invention Chinese crude drug used, return through and effect:
Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae; Sour in the mouth, cold in nature; Return liver, large intestine channel; Removing toxic substances, inhibiting bacteria and diminishing inflammation, diuresis dysentery relieving, intestine moistening disappear stagnant, debug, improving eyesight and suppression metrorrhagia.
Semen Cucurbitae: this product is the seed of cucurbitaceous plant Fructus Cucurbitae moschatae; Sweet in the mouth, property is put down; Return stomach, large intestine channel; Anthelmintic, stimulating milk secretion, inducing diuresis to remove edema.
Semen Arecae: this product is the seed of babassu Semen Arecae; Bitter in the mouth, pungent, warm in nature; Return stomach, large intestine channel; Killing insect and eliminating accumulation, sending down the abnormal ascending QI, row water, preventing the attack (or recurrence) of malaria.
Cortex Phellodendri: this product is the bark of rutaceae Cortex Phellodendri or wampee; Bitter in the mouth, cold in nature; Return kidney, urinary bladder channel; Heat-clearing and toxic substances removing, heat clearing and damp drying.
Fructus Quisqualis: this product is the mature fruit of Combretum Racemosum plant Fructus Quisqualis; Sweet in the mouth, warm in nature; Return spleen, stomach warp; Parasite killing, removing food stagnancy, spleen invigorating.
Rhizoma Corydalis: this product is for being Papaveraceae Corydalis herbaceos perennial; Acrid in the mouth, hardship, warm in nature; GUIXIN, spleen, liver, lung meridian; Blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.
Fructus Ulmus preparatium: this product is the finished product of seed after processing of the large fruit elm of Ulmaceae Elm plant; Acrid in the mouth, hardship, property is put down; Return spleen, stomach warp; Parasite killing, removing food stagnancy.
Chinaberry root: this product is the root of Meliaceae plant chinaberry and Fructus Toosendan; Bitter in the mouth, cold in nature; Return spleen, stomach, Liver Channel; Parasite killing; Treat tinea.
Spina Gleditsiae: this product is the dry Spina jujubae of leguminous plant Fructus Gleditsia; Acrid in the mouth, warm in nature; Return liver, stomach warp; Detumescence poison holding, evacuation of pus, parasite killing.
Rhizoma Osmundae: this product is rhizome and the petiole residual base of Dryopteridaceae plant dryopteris crassirhizoma; Bitter in the mouth, cold in nature; Return liver, stomach warp; Kill ascarid, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis.
Leaf of Moringa: this product is the leaves of deciduous tree Moringa tree; Sweet in the mouth, warm in nature; Return lung, the heart, stomach warp; Blood sugar lowering, blood fat reducing, blood pressure lowering, antitumor, antioxidation, relieving constipation, diuresis, anthelmintic, improving water flood.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; Heat-clearing and toxic substances removing, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription, invigorating the spleen and replenishing QI.
The prescription analysis of Chinese prescription of the present invention:
According to the traditional Chinese medical science to the compatibility theory with the dialectical and Chinese crude drug for the treatment of children intestinal parasite effect, in conjunction with the body constitution of modern and the feature of modern pharmaceutical technology, the collocation ingredients of reasonable science, forms Chinese prescription of the present invention.Prescription of the present invention is with MAZHIXIAN, Semen Cucurbitae for monarch drug, diuresis dysentery relieving, anthelmintic; With Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis and Fructus Ulmus preparatium for ministerial drug, killing insect and eliminating accumulation, heat-clearing and toxic substances removing, promoting the circulation of QI to relieve pain; With chinaberry root, Spina Gleditsiae, Rhizoma Osmundae and leaf of Moringa for adjuvant drug, detumescence poison holding, anthelmintic; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; The all medicines of monarch coordinate, and collaborative promotion, complements each other, finally reach diuresis dysentery relieving, parasite killing, effect of removing food stagnancy, have very significant therapeutic effect to children intestinal parasite.
The present invention also discloses a kind of purposes of above-mentioned Chinese medicine composition, i.e. the application of above-mentioned Chinese medicine composition in preparation treatment children intestinal parasite medicine.The clinical experimental study result display of Chinese medicine composition of the present invention, the cure rate more than 80.0% of Chinese medicine composition of the present invention, total effective rate more than 90.0%, higher than cure rate and the total effective rate of matched group, and take Chinese medicine preparation of the present invention do not have untoward reaction occur, visible, the good effect of Chinese medicine preparation of the present invention, cure rate is high, has no adverse reaction, and can be used as the parasitic drug use for the treatment of children intestinal.
Compared with prior art, Chinese medicine preparation of the present invention has following technical advantage:
1, Chinese medicine preparation of the present invention has removing water retention by purgation relieving constipation, drink is washed in expectorant, parasite killing attacks long-pending, pain relieving preventing or arresting vomiting, increases effect of appetite and stomach invigorating strengthening the spleen.
2, Chinese medicine preparation of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine preparation effect of the present invention is comprehensive, and medication effect is better.
3, Chinese medicine preparation of the present invention also have that compatibility science, preparation technology are simple, curative effect and the advantage such as side effect is low.
4, Chinese medicine preparation of the present invention is compared with the medicine of other treatment Enterozoa, and specific aim is stronger, mainly for children intestinal parasite disease.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1: the preparation of present composition granule
Embodiment 1 Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 2 parts, Semen Cucurbitae 5 parts, Semen Arecae 2 parts, Cortex Phellodendri 2 parts, Fructus Quisqualis 4 parts, Rhizoma Corydalis 2 parts, Fructus Ulmus preparatium 2 parts, chinaberry root 2 parts, Spina Gleditsiae 2 parts, Rhizoma Osmundae 2 parts, leaf of Moringa 2 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 60 mesh sieves, adding medical material gross weight 8 times amount volume fraction is the ethanol of 60%, microwave extraction 8 minutes, microwave power is 240W, and Extracting temperature is 40 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;
(2): get Semen Cucurbitae, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, Fructus Ulmus preparatium, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, leaf of Moringa and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 15 times amount, soak 20 minutes, reflux, extract, 2 times, each 1 hour, filter, merging filtrate, surveys the extractum that relative density is 1.10-1.20 at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40%, 4 DEG C leave standstill 12 hours, filter and retain filtering residue, obtaining filtrate A;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4 times amount volume fraction is the ethanol of 40%, 4 DEG C leave standstill 3 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2 times of 40% again, collects and merges cleaning mixture;
(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;
(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 100 mesh sieves, obtain Chinese medicine preparation of the present invention;
(6): in above-mentioned Chinese medicine preparation, add the filler Icing Sugar of equivalent, wetting agent distilled water, disintegrating agent hydroxypropyl starch and lubricant Pulvis Talci; mix homogeneously; obtain soft material processed; soft material processed is put into rotary extrusion type granulator; obtain wet granular, dry, cross 20 mesh sieve removing big particles; make uniform particles, obtain Chinese medicinal composition granules of the present invention.
embodiment 2: the preparation of present composition granule
Embodiment 2 Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 20 parts, Semen Cucurbitae 20 parts, Semen Arecae 10 parts, Cortex Phellodendri 12 parts, Fructus Quisqualis 16 parts, Rhizoma Corydalis 12 parts, Fructus Ulmus preparatium 8 parts, chinaberry root 8 parts, Spina Gleditsiae 10 parts, Rhizoma Osmundae 10 parts, leaf of Moringa 8 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 80 mesh sieves, adding medical material gross weight 10 times amount volume fraction is the ethanol of 80%, microwave extraction 15 minutes, microwave power is 300W, and Extracting temperature is 60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;
(2): get Semen Cucurbitae, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, Fructus Ulmus preparatium, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, leaf of Moringa and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 20 times amount, soak 30 minutes, reflux, extract, 3 times, each 3 hours, filter, merging filtrate, surveys the extractum that relative density is 1.10-1.20 at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 60%, 4 DEG C leave standstill 24 hours, filter and retain filtering residue, obtaining filtrate A;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 6 times amount volume fraction is the ethanol of 60%, 4 DEG C leave standstill 5 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 3 times of 60% again, collects and merges cleaning mixture;
(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;
(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 200 mesh sieves, obtain Chinese medicine preparation of the present invention;
(6): in above-mentioned Chinese medicine preparation, add the filler Icing Sugar of equivalent, wetting agent distilled water, disintegrating agent hydroxypropyl starch and lubricant Pulvis Talci; mix homogeneously; obtain soft material processed; soft material processed is put into rotary extrusion type granulator; obtain wet granular, dry, cross 20 mesh sieve removing big particles; make uniform particles, obtain Chinese medicinal composition granules of the present invention.
embodiment 3: the preparation of present composition granule
Embodiment 3 Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 12 parts, Semen Cucurbitae 10 parts, Semen Arecae 6 parts, Cortex Phellodendri 7 parts, Fructus Quisqualis 10 parts, Rhizoma Corydalis 7 parts, Fructus Ulmus preparatium 5 parts, chinaberry root 5 parts, Spina Gleditsiae 6 parts, Rhizoma Osmundae 6 parts, leaf of Moringa 5 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
clinical observation on the therapeutic effect
1, case selection: in 400 routine children intestinal parasite clinical volunteers patients, boy patient 220 example, girl patient 180 example, age bracket be 1-12 year, the mean age is 7.5 years old, and all patients are no difference of science of statistics in sex, age, the course of disease.
2, efficacy assessment standard:
Cure: Enterozoa all kills discharge, and related symptoms all disappears, and makes a definite diagnosis fully recover through doctor;
Effective: Enterozoa does not all kill, related symptoms partial disappearance or improvement, still needs further treatment;
Invalid: intestinal parasitical diseases related symptoms is without any improvement, even more serious;
Untoward reaction: patient when according to dosage positive common medicine, the adverse reaction irrelevant with made disease of appearance;
Total effective rate=(cure+effective)/total number of cases × 100%.
3, instructions of taking: 400 patients are divided into 4 groups at random, often organize 100 people, be respectively treatment A group, treatment B group, treatment C group and matched group, treatment A group, treatment B group, treatment component C do not take the granule that the embodiment of the present invention 1,2,3 prepares, every day 2 times, each 10g, serve on two weeks.Matched group takes albendazole tablet (Sino-America Tianjin Shike Pharmaceutical Co., Ltd., the accurate word H12020496 of traditional Chinese medicines), oral, one time 1,3 times on the one, take two weeks.
4, therapeutic outcome: as shown in table 1.
Table 1 therapeutic outcome
This test adopts albendazole tablet as a control group, and albendazole tablet can control parasitic disease, cerebral cysticercosis, anthelmintic, trichuriasis, cysticercosis, enterobiasis, biliary ascariasis, echinococcosis granulosa, filaricide, ancylostomiasis, ascariasis, echinococcosis, infantile ascariasis, trichonematosis.Make inventor surprisingly, the cure rate more than 80.0% of Chinese medicine composition of the present invention, total effective rate more than 90.0%, higher than cure rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of C group, and take Chinese medicine preparation of the present invention and do not have untoward reaction generation, visible, the good effect of Chinese medicine preparation of the present invention, cure rate is high, have no adverse reaction, can be used as the parasitic drug use for the treatment of children intestinal.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (8)
1. the parasitic Chinese medicine preparation for the treatment of children intestinal, it is characterized in that, described Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 2-20 part, Semen Cucurbitae 5-20 part, Semen Arecae 2-10 part, Cortex Phellodendri 2-12 part, Fructus Quisqualis 4-16 part, Rhizoma Corydalis 2-12 part, Fructus Ulmus preparatium 2-8 part, chinaberry root 2-8 part, Spina Gleditsiae 2-10 part, Rhizoma Osmundae 2-10 part, leaf of Moringa 2-8 part and Radix Glycyrrhizae 1-10 part.
2. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 2 parts, Semen Cucurbitae 5 parts, Semen Arecae 2 parts, Cortex Phellodendri 2 parts, Fructus Quisqualis 4 parts, Rhizoma Corydalis 2 parts, Fructus Ulmus preparatium 2 parts, chinaberry root 2 parts, Spina Gleditsiae 2 parts, Rhizoma Osmundae 2 parts, leaf of Moringa 2 parts and 1 part, Radix Glycyrrhizae.
3. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 20 parts, Semen Cucurbitae 20 parts, Semen Arecae 10 parts, Cortex Phellodendri 12 parts, Fructus Quisqualis 16 parts, Rhizoma Corydalis 12 parts, Fructus Ulmus preparatium 8 parts, chinaberry root 8 parts, Spina Gleditsiae 10 parts, Rhizoma Osmundae 10 parts, leaf of Moringa 8 parts and 10 parts, Radix Glycyrrhizae.
4. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is prepared from by the raw material of following parts by weight: Herba Portulacae 12 parts, Semen Cucurbitae 10 parts, Semen Arecae 6 parts, Cortex Phellodendri 7 parts, Fructus Quisqualis 10 parts, Rhizoma Corydalis 7 parts, Fructus Ulmus preparatium 5 parts, chinaberry root 5 parts, Spina Gleditsiae 6 parts, Rhizoma Osmundae 6 parts, leaf of Moringa 5 parts and 6 parts, Radix Glycyrrhizae.
5. the parasitic Chinese medicine preparation for the treatment of children intestinal as described in any one of claim 1-4, is characterized in that: described Chinese medicine preparation is oral formulations.
6. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 5, is characterized in that: described oral formulations is tablet, capsule, granule, powder or oral liquid.
7. the parasitic Chinese medicine preparation for the treatment of children intestinal as described in any one of claim 1-4, is characterized in that, the preparation method of described Chinese medicine preparation comprises following step:
(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 60-80 mesh sieve, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 240-300W, and Extracting temperature is 40-60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;
(2): get Semen Cucurbitae, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, Fructus Ulmus preparatium, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, leaf of Moringa and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, surveys the extractum that relative density is 1.10-1.20 at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;
(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;
(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine preparation of the present invention.
8. the application of Chinese medicine composition according to claim 1 in preparation treatment children intestinal parasite medicine.
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| CN (1) | CN105250563A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749223A (en) * | 2016-03-29 | 2016-07-13 | 广州暨南生物医药研究开发基地有限公司 | Folium-artemisiae-argyi-containing traditional Chinese medicine preparation for preventing and treating child intestinal parasites |
-
2015
- 2015-10-28 CN CN201510709719.7A patent/CN105250563A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749223A (en) * | 2016-03-29 | 2016-07-13 | 广州暨南生物医药研究开发基地有限公司 | Folium-artemisiae-argyi-containing traditional Chinese medicine preparation for preventing and treating child intestinal parasites |
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Application publication date: 20160120 |