CN105012609A - Traditional Chinese medicine preparation for treating pediatric intestinal parasite diseases and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating pediatric intestinal parasite diseases and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine preparation for treating pediatric intestinal parasite diseases and a preparation method thereof. The traditional Chinese medicine preparation comprises the following preparation raw materials: semen pharbitidis, pumpkin seeds, smoked plum, areca catechu, cortex phellodendri, fructus quisqualis, corydalis tuber, fructus ulmi, chinaberry root, spina gleditsiae, cyrtomium fortunei, herba portulacae and liquorice. The traditional Chinese medicine preparation has the efficacy of purging water and relaxing the bowels, dissolving phlegm and flushing rheum, killing parasites and treating retention of food, relieving pain and arresting vomiting, increasing appetite as well as strengthening the stomach and boosting the spleen, and also has the advantages of being simple in preparation process, good in treatment effect, low in side effect, convenient to take and strong in pertinence. The traditional Chinese medicine preparation is mainly used for the population of infants suffering from intestinal parasite diseases.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to one and treat parasitic Chinese medicine preparation of children intestinal and preparation method thereof.
Background technology
The disease that parasite causes at human body intestinal canal endoparasitism is referred to as intestinal parasitical diseases.Common are protozoon class and Vermes (comprising ascarid, ancylostome, pinworm, cestode, whipworm, ameba, giardia lamblia, infusorian etc.).The kind of Enterozoa is many, and complicated in people's endobiosis process, the pathological changes caused is not limited to intestinal.According to the immune state infecting parasitic kind and position and human body host, clinical symptoms and sign different.The factors such as most of intestinal parasitism and local sanitary condition, living habit, health perception, economic level and clustering of disease in family are relevant.
Infant modal intestinal parasitical diseases in period is ascariasis and enterobiasis.Absorb nutrition in the small intestinal that ascarid colonizes in people, cause children's to have no appetite, become thin, evening, sleep was ground one's teeth in sleep, and sometimes suffered from abdominal pain, and formed worm group when worm is many, can also block intestinal tube and form intestinal obstruction, cause violent stomachache, even can cause intestinal perforation.Ascarid pierces bile duct can cause ascariasis of biliary tract, and epigastrium angor is very harmful to infant growth.Pinworm is a kind of short and thin white nematicide, and about have a centimeter length, colonize in small intestinal lower end and large intestine, night of being everlasting is climbed out of by anus, and female worm lays eggs at anal area, thus causes anus very to itch, affects baby sleeping.
Present western medical treatment intestinal parasitical diseases has a lot of medicine and method, mainly adopt the method for parasite killing, but often the course of disease is longer for the patient of trouble intestinal parasitical diseases, cause very large infringement to health and digestive system, adopt western medical treatment can increase the weight of, to the infringement of patient body, also often to have side effect.Chinese medicine has its advantageous advantage controlling in worm, and it can on the basis of parasite killing, and conditioning nourishing digestive system, improve taste and digestive tract function, toxic and side effects is smaller.
Chinese patent application 201410774091.4 discloses the purposes of a kind of Chinese medicine preparation in preparation treatment Enterozoa medicine, the raw material of this Chinese medicine has the 18 taste medical materials such as Fructus Mume, Fructus Toosendan, Fructus Carpesii, Semen Arecae, Omphalia, Fructus Aurantii, Rhizoma Coptidis, Rhizoma Atractylodis, Herba Pogostemonis, Fructus Quisqualis, the Radix Aucklandiae, Semen Torreyae core, Rhizoma Zingiberis, Fructus Zanthoxyli, Radix Bupleuri, Fructus Crataegi, Spina Gleditsiae, Radix Glycyrrhizae, this Chinese medicine has the effect such as function of spleen and stomach regulating, the stagnant relieving distension of row, but specific aim is not strong, especially not remarkable to the parasitic therapeutic effect of children intestinal.
Summary of the invention
The technical problem to be solved in the present invention is to provide one and treats parasitic Chinese medicine preparation of children intestinal and preparation method thereof, this Chinese medicine preparation has removing water retention by purgation relieving constipation, drink is washed in expectorant, parasite killing attacks long-pending, pain relieving preventing or arresting vomiting, increase effect of appetite and stomach invigorating strengthening the spleen, also have that preparation technology is simple, good effect, side effect be low, taking convenience and the advantage such as with strong points, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
Chinese medicine preparation of the present invention is obtained by the raw material of following parts by weight: Semen Pharbitidis 3-15 part, Semen Cucurbitae 6-15 part, Fructus Mume 6-12 part, Semen Arecae 3-9 part, Cortex Phellodendri 3-12 part, Fructus Quisqualis 6-15 part, Rhizoma Corydalis 3-15 part, Fructus Ulmus preparatium 3-10 part, chinaberry root 3-9 part, Spina Gleditsiae 3-9 part, Rhizoma Osmundae 3-10 part, Herba Portulacae 3-9 part and Radix Glycyrrhizae 1-10 part.
Further, described Chinese medicine preparation is obtained by the raw material of following parts by weight: Semen Pharbitidis 3 parts, Semen Cucurbitae 6 parts, Fructus Mume 6 parts, Semen Arecae 3 parts, Cortex Phellodendri 3 parts, Fructus Quisqualis 6 parts, Rhizoma Corydalis 3 parts, Fructus Ulmus preparatium 3 parts, chinaberry root 3 parts, Spina Gleditsiae 3 parts, Rhizoma Osmundae 3 parts, Herba Portulacae 3 parts and 1 part, Radix Glycyrrhizae.
Further, described Chinese medicine preparation is obtained by the raw material of following parts by weight: Semen Pharbitidis 15 parts, Semen Cucurbitae 15 parts, Fructus Mume 12 parts, Semen Arecae 9 parts, Cortex Phellodendri 12 parts, Fructus Quisqualis 15 parts, Rhizoma Corydalis 15 parts, Fructus Ulmus preparatium 10 parts, chinaberry root 9 parts, Spina Gleditsiae 9 parts, Rhizoma Osmundae 10 parts, Herba Portulacae 9 parts and 10 parts, Radix Glycyrrhizae.
Further, described Chinese medicine preparation is obtained by the raw material of following parts by weight: Semen Pharbitidis 10 parts, Semen Cucurbitae 10 parts, Fructus Mume 9 parts, Semen Arecae 6 parts, Cortex Phellodendri 8 parts, Fructus Quisqualis 10 parts, Rhizoma Corydalis 10 parts, Fructus Ulmus preparatium 6 parts, chinaberry root 6 parts, Spina Gleditsiae 6 parts, Rhizoma Osmundae 6 parts, Herba Portulacae 6 parts and 5 parts, Radix Glycyrrhizae.
Further, described Chinese medicine preparation is oral formulations.
Again further, described oral formulations is tablet, capsule, granule, powder or oral liquid.
Accordingly, the preparation method of described Chinese medicine preparation comprises following step:
Step one: take Semen Pharbitidis, Semen Cucurbitae, Fructus Mume, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, adds the purified water of 6-9 times of medical material weight, and backflow decocts 2-4 hour, filter, add the purified water of initial medical material 3-6 times weight in filtering residue, backflow decocts 1-3 hour, filter, by twice filtrate mixing, under 75-80 DEG C of condition, be evaporated to the extractum that relative density is 1.25-1.38, dry, pulverize, levigate, cross 100-120 mesh sieve, obtain fine powder;
Step 2: take Fructus Ulmus preparatium, Herba Portulacae and Radix Glycyrrhizae, slow fire stir-fries, cooling, levigate, cross 100-120 mesh sieve, obtain mixing fine powders, mix with the fine powder that step one obtains, stir, obtain Chinese medicine preparation of the present invention, add adjuvant, be prepared into clinical required preparation according to modern common drug preparation method.
Semen Pharbitidis has another name called Semen Pharbitidis, Semen Pharbitidis, Semen Pharbitidis, trumpet flower, Semen Pharbitidis is the seed of convolvulaceous plant Pharbitis purpurea, Semen Pharbitidis has removing water retention by purgation relieving constipation, drink is washed in expectorant, parasite killing attacks long-pending effect, Semen Pharbitidis cures mainly edema distension, constipation and anuresis, phlegm retention is gathered, QI rising in reverse order is breathed with cough, abdominal pain due to worm stagnation, and anemia of pregnant woman and deficiency of vital energy person with Spleen Deficiency are avoided and taken Semen Pharbitidis.Specially control ascarid, taeniasis.The medical value of morning glory is higher, and wide the writing the poem of Ming Dynasty Wu is praised: " herbal medicine carrying product, careless portion sees and leads a cow.Smoke between wind bamboo or twig fence, climing go out very sentimentally attached." modern pharmacological research analysis, Semen Pharbitidis contains the compositions such as pharbitin, nilic acid, gallic acid, chanoclavine, wild ergine, can stimulate intestinal, strengthen and wriggle, have strong discharge function.
Semen Cucurbitae is the seed of cucurbitaceous plant Fructus Cucurbitae moschatae, be again Fructus Cucurbitae moschatae core, Semen Benincasae, golden melon rice, " golden melon seed ", Chinese squash is sub, pumpkin is sub, effect of Semen Cucurbitae is parasite killing, stimulating milk secretion, inducing diuresis to remove edema, the nutritive value of Semen Cucurbitae is also very abundant, containing carotene, white of an egg matter, and the necessary multiple nutrients composition of the human body such as vitamin A, B1, B2.Cure mainly cestode, ascarid, schistosomicide, ancylostome and enterobiasis.
Fructus Mume another name dark plum, yellow son, conjunction Chinese prunus mume (sieb.) sieb.et zucc., dry branch prunus mume (sieb.) sieb.et zucc. are the dry almost ripe fruit of rosaceae plant deciduous tree prunus mume (sieb.) sieb.et zucc..Sour in the mouth, micro-puckery, property is put down.Return liver, spleen, lung, stomach, large intestine channel.Matter profit is held back puckery, and astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.Fructus Mume also has protection digestive function, antioxidation, purifies the blood and increases the function of appetite.
Semen Arecae is the seed of babassu Semen Arecae, Semen Arecae has effect of anthelmintic, removing food stagnancy, the therapeutic method to keep the adverse QI flowing downwards, Hang Shui, preventing the attack (or recurrence) of malaria, Semen Arecae is called core frequency, Bin Men, guest's door medicine candied fruit, white Semen Arecae, Fructus Canarii albi, is washed miasma pellet, large abdomen Semen Arecae, betel nut, green grass or young crops son, beautiful, the bulky jade of Semen Arecae, Semen Arecae cathartic, and easily consume gas, therefore insufficiency of the spleen loose stool or collapse of QI person avoid use, anemia of pregnant woman is cautious use of Semen Arecae.Children's abdominal pain due to worm stagnation person, Semen Arecae can be equal to Fructus Carpesii, chinaberry root to be used; Cold-damp phlegm retention and cause malaria Chang Fazhe, Semen Arecae is equal to Radix Dichroae, Fructus Tsaoko to be used; Disorder of emotion, QI rising in reverse order dyspnea with rapid respiration, chest and diaphragm is full vexed, anorexia person, and Semen Arecae can grind juice and take with Lignum Aquilariae Resinatum, the Radix Linderae, Radix Ginseng; Abdominal pain due to worm stagnation, dyspepsia person, Semen Arecae can with the compatibilities such as Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Quisqualis; Water is contained by wet heap soil or fertilizer over and around the roots, and disease sees edema all over, breathes dyspnea with rapid respiration, difficulty in urination and defecation person, Semen Arecae can with the compatibility such as Rhizoma Et Radix Notopterygii, Rhizoma Alismatis, Radix Phytolaccae.
Cortex Phellodendri is the bark of rutaceae Cortex Phellodendri or wampee, Cortex Phellodendri another name bark of a cork tree wood, bark of a cork tree skin, Cortex Phellodendri, effect of Cortex Phellodendri is heat-clearing and toxic substances removing, heat clearing and damp drying, the effect of Cortex Phellodendri be control hygropyretic dysentery, have loose bowels, jaundice, nocturnal emission, stranguria with turbid discharge, band be inferior, Cortex Phellodendri bitter cold injures one's stomach, Deficiency and coldness of spleen and stomach person, as diarrhea due to hypofunction of the spleen, the weak lack of appetite person of stomach avoids and takes Cortex Phellodendri.
Fructus Quisqualis is the mature fruit of Combretum Racemosum plant Fructus Quisqualis, Fructus Quisqualis another name stays asks son, history gentleman, five ribs, large rope fruit, winter equal son, sick mandarin orange, Jun Ziren, effect of Fructus Quisqualis: parasite killing, removing food stagnancy, spleen invigorating, the effect of Fructus Quisqualis: control ascarid stomachache, infantile malnutrition, the stagnation of breast food, Fructus Quisqualis medication is avoided: avoid drink hot tea when taking Fructus Quisqualis.Take in a large number and can cause the reactions such as singultus, dizzy, vomiting.
Rhizoma Corydalis has another name called Rhizoma Corydalis, Rhizoma Corydalis, and be Papaveraceae Corydalis herbaceos perennial, Rhizoma Corydalis history is loaded in " Kaibao Bencao ", warm in nature, and acrid in the mouth is bitter, enters the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is especially world-famous for effect of pain relieving.Li Shizhen (1518-1593 A.D.) concludes Rhizoma Corydalis in Compendium of Material Medica " invigorating blood circulation, promoting the circulation of QI, pain relieving, diuresis " four large effects, and praises highly Rhizoma Corydalis " can the stagnation of QI in promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body ".The traditional Chinese medical science is thought, Rhizoma Corydalis pungent loose, hardship is let out, Wen Tong, both enters blood system, and enters edema caused by disorder of QI again, can gas in promoting the circulation of blood, again can blood in circulation of qi promoting, the smooth blood of gas, general rule is not bitterly.Clinical confirmation this product analgesic effect comparatively Olibanum, Myrrha, Oletum Trogopterori is strong, is the pain relieving good medicine in Chinese medicine, has a pain and abdominal pain during menstruation particularly imitates victory to gastral cavilty, and compatibility effect is better.
Fructus Ulmus preparatium is the finished product of seed after processing of the large fruit elm of Ulmaceae Elm plant.Killing insect and eliminating accumulation.For abdominal pain due to worm stagnation, the diseases such as dysentery.Be used for infantile malnutrition, worm pain (ascarid), but the efficacy of a drug is thin, must join Semen Torreyae meat, Semen Arecae, Rhizoma Coptidis, the Radix Aucklandiae etc. to help parasite killing, stomach invigorating, pain relieving.
Medical material chinaberry root is the root of Meliaceae plant chinaberry and Fructus Toosendan, cures mainly the symptoms such as ascariasis, ancylostomiasis, enterobiasis, trichomonal vaginitis, scabies, tinea capitis.
Spina Gleditsiae has detumescence and apocenosis, pus of sterilizing, search effect of wind, parasite killing, Spina Gleditsiae is called: Fructus Gleditsia acupuncture, Spina Gleditsiae, sky fourth, SPINA GLEDITSIAE, soap pin, Spina Gleditsiae is the Spina jujubae of leguminous plant Fructus Gleditsia, and Spina Gleditsiae cures mainly swollen ulcer drug, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy.
Rhizoma Osmundae has kills ascarid, pinworm, heat clearing away, removing toxic substances, removing heat from blood, effect of hemostasis.Control anemopyretic cold, warm macule, spit blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia, skin infection, hematuria, menorrhagia, knife injury is hemorrhage, ascarid, rich worm, taeniasis, artificial abortion, the diseases such as postpartum hemorrhage.
Herba Portulacae has effect of heat-clearing and toxic substances removing, cooling blood for hemostasis.Herba Portulacae Herb be used as medicine there is removing toxic substances, inhibiting bacteria and diminishing inflammation, diuresis dysentery relieving, intestine moistening disappear stagnant, debug, the drug effect such as improving eyesight and suppression metrorrhagia; External can control the disease such as erysipelas, venom.Another name: Wu Hangcao, sour rice dish, longevity greens/mustard green.HERBA PORTULACAE, horse Herba Amaranthi tricoloris, Dens Equi dish, purslane and hairyvein agrimonia, five Medulla Tetrapanacis, long life dish, Herba Peristrophes, grey Herba Amaranthi tricoloris, horse step on dish, beans lobe grass, peaceful and comfortable dish, sour Herba Amaranthi tricoloris, bean plate dish, Semen Benincasae dish, long life Herba Amaranthi tricoloris, beans lobe bean grass, Magnoliacoco, tart flavour dish, the female dish of pig, lion grass, Ma Lai, horse Serpentis dish, Formica fusca dish, longevity greens/mustard green, resistance to Indian Rorippa Herb.
Radix Glycyrrhizae is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., Radix Glycyrrhizae contains number of chemical composition, and main component has glycyrrhizic acid, liquiritin etc., in TCM academic, carry out coordinating the actions of various ingredients in a prescription through conventional Radix Glycyrrhizae, Radix Glycyrrhizae has the effects such as heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI, expelling phlegm for arresting cough.
Compared with prior art, Chinese medicine preparation of the present invention has following technical advantage:
1, Chinese medicine preparation of the present invention has removing water retention by purgation relieving constipation, drink is washed in expectorant, parasite killing attacks long-pending, pain relieving preventing or arresting vomiting, increases effect of appetite and stomach invigorating strengthening the spleen.
2, Chinese medicine preparation of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine preparation effect of the present invention is comprehensive, and medication effect is better.
3, Chinese medicine preparation of the present invention also have that compatibility science, preparation technology are simple, curative effect and the advantage such as side effect is low.
4, Chinese medicine preparation of the present invention is compared with the medicine of other treatment Enterozoa, and specific aim is stronger, mainly for children intestinal parasite disease.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 Chinese medicine preparation comprises the raw materials of following parts by weight: Semen Pharbitidis 3 parts, Semen Cucurbitae 6 parts, Fructus Mume 6 parts, Semen Arecae 3 parts, Cortex Phellodendri 3 parts, Fructus Quisqualis 6 parts, Rhizoma Corydalis 3 parts, Fructus Ulmus preparatium 3 parts, chinaberry root 3 parts, Spina Gleditsiae 3 parts, Rhizoma Osmundae 3 parts, Herba Portulacae 3 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: take Semen Pharbitidis, Semen Cucurbitae, Fructus Mume, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, adds the purified water of 6 times of medical material weight, backflow decoction 2 hours, filter, in filtering residue, add the purified water of initial medical material 3 times of weight, backflow decoction 1 hour, filter, by twice filtrate mixing, under 75 DEG C of conditions, be evaporated to the extractum that relative density is 1.25, dry, pulverize, levigate, cross 100 mesh sieves, obtain fine powder;
Step 2: take Fructus Ulmus preparatium, Herba Portulacae and Radix Glycyrrhizae, slow fire stir-fries, cooling, levigate, cross 100 mesh sieves, obtain mixing fine powders, mix with the fine powder that step one obtains, stir, obtain the embodiment of the present invention 1 Chinese medicine preparation.Add starch, distilled water, rubber cement, mix homogeneously, be pressed into thin slice, be ground into granule, obtain the granule that the embodiment of the present invention 1 obtains.
embodiment 2:
The embodiment of the present invention 2 Chinese medicine preparation comprises the raw materials of following parts by weight: Semen Pharbitidis 15 parts, Semen Cucurbitae 15 parts, Fructus Mume 12 parts, Semen Arecae 9 parts, Cortex Phellodendri 12 parts, Fructus Quisqualis 15 parts, Rhizoma Corydalis 15 parts, Fructus Ulmus preparatium 10 parts, chinaberry root 9 parts, Spina Gleditsiae 9 parts, Rhizoma Osmundae 10 parts, Herba Portulacae 9 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: take Semen Pharbitidis, Semen Cucurbitae, Fructus Mume, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, adds the purified water of 7 times of medical material weight, backflow decoction 3 hours, filter, in filtering residue, add the purified water of initial medical material 5 times of weight, backflow decoction 2 hours, filter, by twice filtrate mixing, under 78 DEG C of conditions, be evaporated to the extractum that relative density is 1.30, dry, pulverize, levigate, cross 100 mesh sieves, obtain fine powder;
Step 2: take Fructus Ulmus preparatium, Herba Portulacae and Radix Glycyrrhizae, slow fire stir-fries, cooling, levigate, cross 100 mesh sieves, obtain mixing fine powders, mix with the fine powder that step one obtains, stir, obtain the embodiment of the present invention 2 Chinese medicine preparation.Add starch, distilled water, rubber cement, mix homogeneously, be pressed into thin slice, be ground into granule, obtain the granule that the embodiment of the present invention 2 obtains.
embodiment 3:
The embodiment of the present invention 3 Chinese medicine preparation comprises the raw materials of following parts by weight: Semen Pharbitidis 10 parts, Semen Cucurbitae 10 parts, Fructus Mume 9 parts, Semen Arecae 6 parts, Cortex Phellodendri 8 parts, Fructus Quisqualis 10 parts, Rhizoma Corydalis 10 parts, Fructus Ulmus preparatium 6 parts, chinaberry root 6 parts, Spina Gleditsiae 6 parts, Rhizoma Osmundae 6 parts, Herba Portulacae 6 parts and 5 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: take Semen Pharbitidis, Semen Cucurbitae, Fructus Mume, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, adds the purified water of 9 times of medical material weight, backflow decoction 4 hours, filter, in filtering residue, add the purified water of initial medical material 6 times of weight, backflow decoction 3 hours, filter, by twice filtrate mixing, under 80 DEG C of conditions, be evaporated to the extractum that relative density is 1.38, dry, pulverize, levigate, cross 120 mesh sieves, obtain fine powder;
Step 2: take Fructus Ulmus preparatium, Herba Portulacae and Radix Glycyrrhizae, slow fire stir-fries, cooling, levigate, cross 120 mesh sieves, obtain mixing fine powders, mix with the fine powder that step one obtains, stir, obtain the embodiment of the present invention 3 Chinese medicine preparation.Add starch, distilled water, rubber cement, mix homogeneously, be pressed into thin slice, be ground into granule, obtain the granule that the embodiment of the present invention 3 obtains.
clinical observation on the therapeutic effect
1, case selection: in 300 routine children intestinal parasite clinical volunteers patients, male patient 180 example, female patient 120 example, age bracket be 1-12 year, the mean age is 6.5 years old, and all patients are no difference of science of statistics in sex, age, the course of disease.
2, efficacy assessment standard:
Cure: Enterozoa all kills discharge, and related symptoms all disappears, and makes a definite diagnosis fully recover through doctor;
Effective: Enterozoa does not all kill, related symptoms partial disappearance or improvement, still needs to control further
Treat;
Invalid: intestinal parasitical diseases related symptoms is without any improvement, even more serious;
Untoward reaction: patient when according to dosage positive common medicine, the adverse reaction irrelevant with made disease of appearance;
Total effective rate=(cure+effective)/total number of cases × 100%.
3, instructions of taking: 300 patients are divided into 4 groups at random, often organize 75 people, be respectively treatment A group, treatment B group, treatment C group and matched group, treatment A group, treatment B group, treatment component C do not take the granule that the embodiment of the present invention 1,2,3 prepares, every day 2 times, each 15g, serve on two weeks.Matched group takes albendazole tablet (Sino-America Tianjin Shike Pharmaceutical Co., Ltd., the accurate word H12020496 of traditional Chinese medicines), oral, one time 1,3 times on the one, take two weeks.
4, therapeutic outcome: as shown in table 1.
table 1 therapeutic outcome
This test adopts albendazole tablet as a control group, and albendazole tablet can control parasitic disease, cerebral cysticercosis, anthelmintic, trichuriasis, cysticercosis, enterobiasis, biliary ascariasis, echinococcosis granulosa, filaricide, ancylostomiasis, ascariasis, echinococcosis, infantile ascariasis, trichonematosis.Make inventor surprisingly, the cure rate of Chinese medicine composition of the present invention reaches more than 80.0%, total effective rate reaches more than 90.0%, higher than cure rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of C group, and take Chinese medicine preparation of the present invention do not have untoward reaction occur, visible, the good effect of Chinese medicine preparation of the present invention, cure rate is high, can be used as the parasitic drug use for the treatment of children intestinal.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (7)
1. treat the parasitic Chinese medicine preparation of children intestinal, it is characterized in that being obtained by the raw material of following weight portion: Semen Pharbitidis 3-15 part, Semen Cucurbitae 6-15 part, Fructus Mume 6-12 part, Semen Arecae 3-9 part, Cortex Phellodendri 3-12 part, Fructus Quisqualis 6-15 part, Rhizoma Corydalis 3-15 part, Fructus Ulmus preparatium 3-10 part, chinaberry root 3-9 part, Spina Gleditsiae 3-9 part, Rhizoma Osmundae 3-10 part, Herba Portulacae 3-9 part and Radix Glycyrrhizae 1-10 part.
2. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 1, is characterized in that being obtained by the raw material of following weight portion: Semen Pharbitidis 3 parts, Semen Cucurbitae 6 parts, Fructus Mume 6 parts, Semen Arecae 3 parts, Cortex Phellodendri 3 parts, Fructus Quisqualis 6 parts, Rhizoma Corydalis 3 parts, Fructus Ulmus preparatium 3 parts, chinaberry root 3 parts, Spina Gleditsiae 3 parts, Rhizoma Osmundae 3 parts, Herba Portulacae 3 parts and 1 part, Radix Glycyrrhizae.
3. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 1, is characterized in that being obtained by the raw material of following weight portion: Semen Pharbitidis 15 parts, Semen Cucurbitae 15 parts, Fructus Mume 12 parts, Semen Arecae 9 parts, Cortex Phellodendri 12 parts, Fructus Quisqualis 15 parts, Rhizoma Corydalis 15 parts, Fructus Ulmus preparatium 10 parts, chinaberry root 9 parts, Spina Gleditsiae 9 parts, Rhizoma Osmundae 10 parts, Herba Portulacae 9 parts and 10 parts, Radix Glycyrrhizae.
4. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 1, is characterized in that being obtained by the raw material of following weight portion: Semen Pharbitidis 10 parts, Semen Cucurbitae 10 parts, Fructus Mume 9 parts, Semen Arecae 6 parts, Cortex Phellodendri 8 parts, Fructus Quisqualis 10 parts, Rhizoma Corydalis 10 parts, Fructus Ulmus preparatium 6 parts, chinaberry root 6 parts, Spina Gleditsiae 6 parts, Rhizoma Osmundae 6 parts, Herba Portulacae 6 parts and 5 parts, Radix Glycyrrhizae.
5. the parasitic Chinese medicine preparation for the treatment of children intestinal as described in as arbitrary in claim 1-4, is characterized in that: described Chinese medicine preparation is oral formulations.
6. the parasitic Chinese medicine preparation for the treatment of children intestinal as claimed in claim 5, is characterized in that: described oral formulations is tablet, capsule, granule, powder or oral liquid.
7. prepare as arbitrary in claim 1-4 as described in the method for the parasitic Chinese medicine preparation for the treatment of children intestinal, it is characterized in that comprising the steps:
(1) take Semen Pharbitidis, Semen Cucurbitae, Fructus Mume, Semen Arecae, Cortex Phellodendri, Fructus Quisqualis, Rhizoma Corydalis, chinaberry root, Spina Gleditsiae, Rhizoma Osmundae, add the purified water of 6-9 times of medical material weight, backflow decocts 2-4 hour, filter, add the purified water of initial medical material 3-6 times weight in filtering residue, backflow decocts 1-3 hour, filter, by twice filtrate mixing, under 75-80 DEG C of condition, be evaporated to the extractum that relative density is 1.25-1.38, dry, pulverize, levigate, cross 100-120 mesh sieve, obtain fine powder;
(2) take Fructus Ulmus preparatium, Herba Portulacae and Radix Glycyrrhizae, slow fire stir-fries, cooling, levigate, cross 100-120 mesh sieve, obtain mixing fine powders, mix with the fine powder that step one obtains, stir, obtain Chinese medicine preparation of the present invention, add adjuvant, be prepared into clinical required preparation according to modern common drug preparation method.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105749223A (en) * | 2016-03-29 | 2016-07-13 | 广州暨南生物医药研究开发基地有限公司 | Folium-artemisiae-argyi-containing traditional Chinese medicine preparation for preventing and treating child intestinal parasites |
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| CN103566329A (en) * | 2012-07-27 | 2014-02-12 | 范国军 | Traditional Chinese medicine composition for treating ascariasis |
| CN104208336A (en) * | 2014-09-18 | 2014-12-17 | 青岛润鑫伟业科贸有限公司 | Traditional Chinese medicine pill for repelling pests |
| CN104491798A (en) * | 2014-12-16 | 2015-04-08 | 广东聚智诚科技有限公司 | Traditional Chinese medicine preparation for treating intestinal parasites and preparation process thereof |
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| CN1205215A (en) * | 1997-07-10 | 1999-01-20 | 张富永 | Parasitosis eliminating powder |
| CN101596305A (en) * | 2009-07-03 | 2009-12-09 | 周大红 | A kind of aloxyin granule |
| CN103566329A (en) * | 2012-07-27 | 2014-02-12 | 范国军 | Traditional Chinese medicine composition for treating ascariasis |
| CN104208336A (en) * | 2014-09-18 | 2014-12-17 | 青岛润鑫伟业科贸有限公司 | Traditional Chinese medicine pill for repelling pests |
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| CN105749223A (en) * | 2016-03-29 | 2016-07-13 | 广州暨南生物医药研究开发基地有限公司 | Folium-artemisiae-argyi-containing traditional Chinese medicine preparation for preventing and treating child intestinal parasites |
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Application publication date: 20151104 |