CN104491798A - Traditional Chinese medicine preparation for treating intestinal parasites and preparation process thereof - Google Patents
Traditional Chinese medicine preparation for treating intestinal parasites and preparation process thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating intestinal parasites and a preparation process thereof and belongs to the field of traditional Chinese medicines. Traditional Chinese medicine raw materials of the traditional Chinese medicine preparation comprise eighteen medicinal materials, such as black plum, toosendan fruit, carpesium fruit, areca catechu, omphalia, fructus aurantii, cortex phellodendri, atractylodes rhizome, atractylodes macrocephala, quisqualis indica, costus root, Chinese torreya seed, dried ginger, Sichuan pepper, cassia twig, crataegus pinnatifida, spina gleditsiae and glycyrrhiza uralensis. The traditional Chinese medicines can be prepared into the traditional Chinese medicine preparation, which is convenient and easy to take, by using the preparation process disclosed by the invention. During the treatment of the intestinal parasites, the preparation not only has the treatment advantages of high effect taking speed, thoroughness in parasite killing, spleen and stomach conditioning, stagnation removing and distention relieving and the like, but also has the technical advantages of simple, convenient and easy preparation process, stable drug effect, little individual difference, easiness in popularization and application and the like.
Description
Technical field
The present invention discloses a kind of Chinese medicine preparation and the preparation technology thereof that treat Enterozoa, belongs to the field of Chinese medicines.
Background technology
The disease that parasite causes at human body intestinal canal endoparasitism is referred to as intestinal parasitical diseases.Common are protozoon class and Vermes (comprising ascarid, ancylostome, pinworm, cestode, whipworm, ameba, giardia lamblia, infusorian etc.).The kind of Enterozoa is many, and complicated in people's endobiosis process, the pathological changes caused is not limited to intestinal.According to the immune state infecting parasitic kind and position and human body host, clinical symptoms and sign different.
Present western medical treatment intestinal parasitical diseases has a lot of medicine and method, but often the course of disease is longer for the patient of trouble intestinal parasitical diseases, and cause very large infringement to health and digestive system, western medical treatment method is exactly parasite killing, also often has side effect.Chinese medicine has its advantageous advantage controlling in worm, and it can on the basis of parasite killing, and conditioning nourishing digestive system, improves taste and digestive tract function, do not have toxic and side effects.
Summary of the invention
The technical problem to be solved in the present invention is a kind of Chinese medicine for the treatment of Enterozoa of exploitation, and this Chinese medicine can meet modern clinic requirement, can make and facilitate easy-to-use finished product preparation on the basis ensureing curative effect.
In order to solve the problems of the technologies described above, the technical scheme of inventor is: according to the traditional Chinese medical science to the dialectical cognition controlling worm, in conjunction with the feature of self clinical practise medicine experience and modern Enterozoa, again compatibility medical material, through adjustment repeatedly and the checking of clinical practice, final acquisition one has the Chinese prescription of significant curative effect to Enterozoa, and by a series of scientific research, this prescription is made finished product preparation when ensureing drug effect, and preparation technology is simple and easy to do, efficacy stability, individual variation are little, be easy to apply.Chinese prescription in technical scheme is (with parts by weight):
Fructus Mume 15-25 part, Fructus Toosendan 6-14 part, Fructus Carpesii 10-20 part, Semen Arecae 15-29 part, Omphalia 14-26 part, Fructus Aurantii 8-18 part, Cortex Phellodendri 7-15 part, Rhizoma Atractylodis 9-19 part, Rhizoma Atractylodis Macrocephalae 9-17 part, Fructus Quisqualis 9-19 part, Radix Aucklandiae 7-13 part, Semen Torreyae core 12-24 part, Rhizoma Zingiberis 6-14 part, Fructus Zanthoxyli 7-15 part, Ramulus Cinnamomi 7-17 part, Fructus Crataegi 8-20 part, Spina Gleditsiae 5-10 part, Radix Glycyrrhizae 8-16 part.
Three preferred prescriptions are out:
Preferably 1: Fructus Mume 20 parts, Fructus Toosendan 10 parts, Fructus Carpesii 15 parts, Semen Arecae 22 parts, Omphalia 20 parts, Fructus Aurantii 13 parts, Cortex Phellodendri 11 parts, Rhizoma Atractylodis 14 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Fructus Quisqualis 14 parts, the Radix Aucklandiae 10 parts, Semen Torreyae core 18 parts, Rhizoma Zingiberis 10 parts, Fructus Zanthoxyli 11 parts, Ramulus Cinnamomi 12 parts, Fructus Crataegi 14 parts, Spina Gleditsiae 7 parts, 12 parts, Radix Glycyrrhizae.
Preferably 2: Fructus Mume 22 parts, Fructus Toosendan 9 parts, Fructus Carpesii 17 parts, Semen Arecae 24 parts, Omphalia 19 parts, Fructus Aurantii 12 parts, Cortex Phellodendri 10 parts, Rhizoma Atractylodis 15 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Quisqualis 12 parts, the Radix Aucklandiae 9 parts, Semen Torreyae core 19 parts, Rhizoma Zingiberis 11 parts, Fructus Zanthoxyli 13 parts, Ramulus Cinnamomi 11 parts, Fructus Crataegi 12 parts, Spina Gleditsiae 9 parts, 13 parts, Radix Glycyrrhizae.
Preferably 3: Fructus Mume 19 parts, Fructus Toosendan 11 parts, Fructus Carpesii 16 parts, Semen Arecae 23 parts, Omphalia 22 parts, Fructus Aurantii 14 parts, Cortex Phellodendri 12 parts, Rhizoma Atractylodis 12 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Fructus Quisqualis 15 parts, the Radix Aucklandiae 11 parts, Semen Torreyae core 17 parts, Rhizoma Zingiberis 9 parts, Fructus Zanthoxyli 10 parts, Ramulus Cinnamomi 11 parts, Fructus Crataegi 13 parts, Spina Gleditsiae 8 parts, 11 parts, Radix Glycyrrhizae.
The processing step this Chinese prescription being made finished product preparation is:
(1), in prescription ratio accurately take each taste raw medicinal material, pulverize respectively, for subsequent use;
(2), ingredients is mixed, add 6-11 purified water doubly, soak 12-24 hour, backflow decocts 2-4 hour, filter, add the purified water of 4-7 times of weight again, backflow decocts 1-3 hour, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the filtering residue of step (2) is added the edible ethanol solution of the 60-75% of 6-9 times of weight, backflow decocts 2-4 hour, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
(4), by water extracting liquid mix with alcohol extraction concentrated solution, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
(5), modern general Chinese medicine preparation technology is utilized Chinese medical concrete to be made the finished product preparation of clinical needs, such as: the dosage forms such as capsule, tablet, pill, granule, powder, syrup.
The character of the raw material of Chinese medicine medical material that the present invention is used and source:
Fructus Mume: this product is the dry almost ripe fruit of rose department plant plum.Sour in the mouth, puckery, property is put down; Return liver, spleen, lung, large intestine channel; Astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.
Fructus Toosendan: this product is the dry mature fruit of Meliaceae plant Fructus Toosendan.Bitter in the mouth, cold in nature; Return liver, small intestinal, urinary bladder channel; Soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.
Fructus Carpesii: be the fruit of feverfew Radix Carpesii.Bitter in the mouth; Pungent; Property is put down; Return spleen; Stomach; Large intestine channel; Killing insect and eliminating accumulation.
Semen Arecae: this product is the dry mature seed of babassu Semen Arecae.Bitter in the mouth, pungent, warm in nature; Return stomach, large intestine channel; Killing insect and eliminating accumulation, sending down the abnormal ascending QI, row water, preventing the attack (or recurrence) of malaria.
Omphalia: this product is the dry sclerotia of Bai Mo section fungus Omphalia; Mildly bitter flavor, cold in nature; Return stomach, large intestine channel; Killing insect and eliminating accumulation.
Fructus Aurantii: this product is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.Bitter in the mouth, pungent, sour, warm in nature; Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.
Cortex Phellodendri: this product is the dry bark of rutaceae wampee or Cortex Phellodendri.Bitter in the mouth, cold in nature; Return kidney, urinary bladder channel; Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. or Atractylis chinensis.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp; Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.
Fructus Quisqualis: this product is the dry mature fruit of Combretum Racemosum plant Fructus Quisqualis.Sweet in the mouth, warm in nature; Return spleen, stomach warp; Killing insect and eliminating accumulation.
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians; Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.
Semen Torreyae core: this product is the dry mature seed of taxaceae plant Chinese torreya.Sweet in the mouth, property is put down; Return lung, stomach, large intestine channel; Killing insect and eliminating accumulation, moistening dryness for relaxing bowels.
Rhizoma Zingiberis: this product is the dry rhizome of zingiber.Acrid in the mouth, hot in nature; Return spleen, stomach, kidney, the heart, lung meridian; Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.
Fructus Zanthoxyli: this product is that the dry mature skin (Pericarpium Zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)) and seed (Semen zanthoxyli) are used as medicine.Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Warming middle-JIAO to relieve pain, killing parasites for relieving itching.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi.Acrid in the mouth, sweet, warm in nature; GUIXIN, lung, urinary bladder channel; Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Fructus Crataegi: this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.Sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel; Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.
Spina Gleditsiae: this product is the dry Spina jujubae of leguminous plant Fructus Gleditsia.Acrid in the mouth, warm in nature; Return liver, stomach warp; Detumescence poison holding, evacuation of pus, parasite killing.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
The present invention is that astringing intestine to stop diarrhea promotes the production of body fluid, killing insect and eliminating accumulation, moistening dryness for relaxing bowels with Fructus Mume, Semen Arecae, Omphalia, Fructus Carpesii, Semen Torreyae core for monarch drug; With Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Fructus Quisqualis, Fructus Crataegi for ministerial drug, drying damp and strengthening spleen, invigorating the spleen and benefiting QI, killing insect and eliminating accumulation, promoting digestion and invigorating the stomach; With Fructus Toosendan, Fructus Aurantii, Fructus Zanthoxyli, Spina Gleditsiae for adjuvant drug, pain relieving anthelmintic, the stagnant relieving distension of row, warming middle-JIAO to relieve pain, detumescence poison holding; With Cortex Phellodendri, the Radix Aucklandiae, Rhizoma Zingiberis, Ramulus Cinnamomi for making medicine, pathogenic fire purging except steaming, promoting the circulation of QI to relieve pain, recuperating depleted YANG promote blood circulation, supporing yang activating QI; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, make all medicine coordinated, complement each other, jointly reach the effects such as killing insect and eliminating accumulation, moistening dryness for relaxing bowels, the stagnant relieving distension of row, detumescence poison holding, thus to the treatment of Enterozoa, there is very significant effect.
Compared with prior art, Chinese medicine preparation of the present invention not only have instant effect, parasite killing thoroughly, function of spleen and stomach regulating, the treatment advantage such as the stagnant relieving distension of row, and have that preparation technology is simple and easy to do, efficacy stability, individual variation are little, be easy to technical advantages such as applying.
Detailed description of the invention
Embodiment 1
Produce by Chinese prescription scope minimum scale of the present invention:
(1), accurately take in prescription ratio: Fructus Mume 15kg, Fructus Toosendan 6kg, Fructus Carpesii 10kg, Semen Arecae 15kg, Omphalia 14kg, Fructus Aurantii 8kg, Cortex Phellodendri 7kg, Rhizoma Atractylodis 9kg, Rhizoma Atractylodis Macrocephalae 9kg, Fructus Quisqualis 9g, Radix Aucklandiae 7kg, Semen Torreyae core 12kg, Rhizoma Zingiberis 6kg, Fructus Zanthoxyli 7kg, Ramulus Cinnamomi 7kg, Fructus Crataegi 8kg, Spina Gleditsiae 5kg, Radix Glycyrrhizae 8kg, pulverize respectively, for subsequent use;
(2), ingredients is mixed, add the purified water of 9 times, soak 14 hours, backflow decoction 3 hours, filter, add the purified water of 5 times of weight again, backflow decoction 2 hours, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the filtering residue of step (2) is added the edible ethanol solution of 70% of 7 times of weight, backflow decoction 3 hours, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
(4), by water extracting liquid mix with alcohol extraction concentrated solution, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
(5), utilize modern general Chinese medicine preparation technology that Chinese medical concrete is made granule, amounting to crude drug content is 0.18g crude drug/g granule.
Embodiment 2
Produce by Chinese prescription scope maximum ratio of the present invention:
(1), accurately take in prescription ratio: Fructus Mume 25kg, Fructus Toosendan 14kg, Fructus Carpesii 20kg, Semen Arecae 29kg, Omphalia 26kg, Fructus Aurantii 18kg, Cortex Phellodendri 15kg, Rhizoma Atractylodis 19kg, Rhizoma Atractylodis Macrocephalae 17kg, Fructus Quisqualis 19kg, Radix Aucklandiae 13kg, Semen Torreyae core 24kg, Rhizoma Zingiberis 14kg, Fructus Zanthoxyli 15kg, Ramulus Cinnamomi 17kg, Fructus Crataegi 20kg, Spina Gleditsiae 10kg, Radix Glycyrrhizae 16kg, pulverize respectively, for subsequent use;
(2), ingredients is mixed, add the purified water of 9 times, soak 14 hours, backflow decoction 3 hours, filter, add the purified water of 5 times of weight again, backflow decoction 2 hours, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the filtering residue of step (2) is added the edible ethanol solution of 70% of 7 times of weight, backflow decoction 3 hours, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
(4), by water extracting liquid mix with alcohol extraction concentrated solution, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
(5), utilize modern general Chinese medicine preparation technology that Chinese medical concrete is made granule, amounting to crude drug content is 0.18g crude drug/g granule.
Embodiment 3
Produce by arbitrary proportion within the scope of Chinese prescription of the present invention:
(1), accurately take in prescription ratio: Fructus Mume 15kg, Fructus Toosendan 14kg, Fructus Carpesii 120kg, Semen Arecae 15kg, Omphalia 26kg, Fructus Aurantii 8kg, Cortex Phellodendri 7kg, Rhizoma Atractylodis 19kg, Rhizoma Atractylodis Macrocephalae 9kg, Fructus Quisqualis 19kg, Radix Aucklandiae 7kg, Semen Torreyae core 24kg, Rhizoma Zingiberis 6kg, Fructus Zanthoxyli 7kg, Ramulus Cinnamomi 17kg, Fructus Crataegi 20kg, Spina Gleditsiae 5kg, Radix Glycyrrhizae 16kg, pulverize respectively, for subsequent use;
(2), ingredients is mixed, add the purified water of 9 times, soak 14 hours, backflow decoction 3 hours, filter, add the purified water of 5 times of weight again, backflow decoction 2 hours, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the filtering residue of step (2) is added the edible ethanol solution of 70% of 7 times of weight, backflow decoction 3 hours, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
(4), by water extracting liquid mix with alcohol extraction concentrated solution, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
(5), utilize modern general Chinese medicine preparation technology that Chinese medical concrete is made granule, amounting to crude drug content is 0.18g crude drug/g granule.
Embodiment 4
Produce by Chinese prescription preferred proportion 1 of the present invention:
(1), accurately take in prescription ratio: Fructus Mume 20kg, Fructus Toosendan 10kg, Fructus Carpesii 15kg, Semen Arecae 22kg, Omphalia 20kg, Fructus Aurantii 13kg, Cortex Phellodendri 11kg, Rhizoma Atractylodis 14kg, Rhizoma Atractylodis Macrocephalae 13kg, Fructus Quisqualis 14kg, Radix Aucklandiae 10kg, Semen Torreyae core 18kg, Rhizoma Zingiberis 10kg, Fructus Zanthoxyli 11kg, Ramulus Cinnamomi 12kg, Fructus Crataegi 14kg, Spina Gleditsiae 7kg, Radix Glycyrrhizae 12kg, pulverize respectively, for subsequent use;
(2), ingredients is mixed, add the purified water of 9 times, soak 14 hours, backflow decoction 3 hours, filter, add the purified water of 5 times of weight again, backflow decoction 2 hours, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the filtering residue of step (2) is added the edible ethanol solution of 70% of 7 times of weight, backflow decoction 3 hours, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
(4), by water extracting liquid mix with alcohol extraction concentrated solution, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
(5), utilize modern general Chinese medicine preparation technology that Chinese medical concrete is made granule, amounting to crude drug content is 0.18g crude drug/g granule.
Embodiment 5
Produce by Chinese prescription preferred proportion 2 of the present invention:
(1), accurately take in prescription ratio: Fructus Mume 22kg, Fructus Toosendan 9kg, Fructus Carpesii 17kg, Semen Arecae 24kg, Omphalia 19kg, Fructus Aurantii 12kg, Cortex Phellodendri 10kg, Rhizoma Atractylodis 15kg, Rhizoma Atractylodis Macrocephalae 14kg, Fructus Quisqualis 12kg, Radix Aucklandiae 9kg, Semen Torreyae core 19kg, Rhizoma Zingiberis 11kg, Fructus Zanthoxyli 13kg, Ramulus Cinnamomi 11kg, Fructus Crataegi 12kg, Spina Gleditsiae 9kg, Radix Glycyrrhizae 13kg, pulverize respectively, for subsequent use;
(2), ingredients is mixed, add the purified water of 9 times, soak 14 hours, backflow decoction 3 hours, filter, add the purified water of 5 times of weight again, backflow decoction 2 hours, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the filtering residue of step (2) is added the edible ethanol solution of 70% of 7 times of weight, backflow decoction 3 hours, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
(4), by water extracting liquid mix with alcohol extraction concentrated solution, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
(5), utilize modern general Chinese medicine preparation technology that Chinese medical concrete is made granule, amounting to crude drug content is 0.18g crude drug/g granule.
Embodiment 6
Produce by Chinese prescription preferred proportion 3 of the present invention:
(1), accurately take in prescription ratio: Fructus Mume 19kg, Fructus Toosendan 11kg, Fructus Carpesii 16kg, Semen Arecae 23kg, Omphalia 22kg, Fructus Aurantii 14kg, Cortex Phellodendri 12kg, Rhizoma Atractylodis 12kg, Rhizoma Atractylodis Macrocephalae 11kg, Fructus Quisqualis 15kg, Radix Aucklandiae 11kg, Semen Torreyae core 17kg, Rhizoma Zingiberis 9kg, Fructus Zanthoxyli 10kg, Ramulus Cinnamomi 11kg, Fructus Crataegi 13kg, Spina Gleditsiae 8kg, Radix Glycyrrhizae 11kg, pulverize respectively, for subsequent use;
(2), ingredients is mixed, add the purified water of 9 times, soak 14 hours, backflow decoction 3 hours, filter, add the purified water of 5 times of weight again, backflow decoction 2 hours, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the filtering residue of step (2) is added the edible ethanol solution of 70% of 7 times of weight, backflow decoction 3 hours, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
(4), by water extracting liquid mix with alcohol extraction concentrated solution, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
(5), utilize modern general Chinese medicine preparation technology that Chinese medical concrete is made granule, amounting to crude drug content is 0.18g crude drug/g granule.
Embodiment 7
Embodiment 1-6 produce granule the animal property moved test
1, acute toxicity test
(1), the granule produced of tested medicine: embodiment of the present invention 1-6, add purified water and be modulated into scattered paste shape.
(2), experimental animal: regular grade NIH mice, body weight 23g ± 4g, male and female half and half, female mice is all without pregnant.
(3), to the magma that mouse stomach Chinese medicine granules of the present invention is made, when given low reaches 667.2g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 2 hours recover normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal.
(4), result of the test shows: the maximum dosage-feeding of the made granule of mouse stomach embodiment 1-6 is 667.2g crude drug/kg/d(LD
50> 667.2g crude drug/kg).Chinese medicine powder clinical application every day total amount of the present invention is 0.12g crude drug/kg/d to the maximum; By weighing machine, the dosis tolerata of the made granule of mouse stomach embodiment 1-6 is 5560 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
2, long term toxicity test
1, test objective: the toxic reaction of viewing test animal after long-term edible Chinese medicine preparation of the present invention, assesses the basic security of Chinese medicine preparation of the present invention.
2, test material:
(1), animal: select adult healthy SD rat 210, original body mass 220 ± 11g, male and female half and half, female rats is all without pregnant.
(2), medicine: Chinese medicine granules obtained by embodiment of the present invention 1-6, adds purified water and make magma, for subsequent use.Per weight dosage is by 20 times of calculating (clinical application amount foundation Pharmacopoeia of the People's Republic of China version in 2010) of clinical application amount, and dosage is 2.4g crude drug/kg/d, and granule dose is 13.3g granule/kg/d.
3, test method
(1), by 210 SD rats be divided into 7 groups, often organize 30, male and female half and half.Experimental animal male and female sub-cage rearing, 5, every cage, quantitative feeding (every cage 1300-1500g/ week), normal feedstuff is experimental mouse full-valence pellet feed, freely drinks water.Experimental temperature (22 ± 2) DEG C, humidity 60%-80%.The natural lighting light and shade cycle.After SD rat is bought, under this laboratory rearing condition, adapt to 2 weeks, observe general behavior performance.Test pre-test animal ingestion amount, selects qualified rat.
(2), medication
With 6 kinds of granules obtained by embodiment 1-6, to wherein 6 groups of SD rat oral gavages administration, every day 2 times, each volume is 0.2ml/10g body weight, successive administration 26 weeks.Remaining one group is matched group, by same method gavage normal saline.Experimental animal is weighed weekly 1 time, according to body weight change adjustment dosage.24h after administration in the 13rd week, often organize execution 10, male and female half and half, observe and detect indices; Remaining continuation administration was observed to 26 weeks, and 24h after last 1 administration, often organizes and put to death 10 again, male and female half and half, observe and detect indices; Remaining 10 are carried out 8 week convalescent period and observe.
(3), test item and the time
General inspection: the general status observing animal every day, as the mental status, dynamic response, behavioral activity, the change of dietary amount, defecation situation, eyes and duct secretions, hair color, cleannes etc.Body weight change situation and food ration measure weekly 1 time.
Hematological examination: after administration, the 13rd, 26 week and drug withdrawal recover the end of term (the 34th week) and detect following index respectively: packed cell volume (HCT), red blood cell count(RBC) (RBC), content of hemoglobin (HGB), numeration of leukocyte (WBC), lymphocyte comparative counting (LY), platelet count (PLT), neutrophilic granulocyte comparative counting (NE), mononuclear cell comparative counting (Mon) and clotting time (CT).
Blood parameters check: after administration the 13rd, 26 week and drug withdrawal recovery the end of term (the 34th week) detect following index respectively: alanine aminotransferase (ALT), alkali phosphatase (AST), Lomefloxacin aspartate injection (AST), total bilirubin (TB), albumin (ALB), gross protein (TP), blood glucose (GLU), blood urea nitrogen (BUN), T-CHOL (TC), creatinine (Crea), uric acid (UA), blood sodium (Na
+), blood potassium (K
+), blood calcium (Ca
+) and β
2-microglobulin.
Urinate biochemical and urine routine: after administration, the 13rd, 26 week and drug withdrawal recover the end of term (the 34th week) each survey 1 time.Animal metabolism cage list cage is raised and is collected 24h urine, overnight fasting before test, detects urine bilirubin (BIL), glucose (GLU), ketoboidies (KET), protein, pH value, urobilinogen (URO), urine is occulted blood (BLO), nitrite (NIT), proportion and leukocyte (WBC); Quantitative determination of radioimmunoassay urine β
2-MG(renal tubular function obstacle sensitive indicator).
System postmortem and histopathologic examination: macroscopy is carried out to each internal organs, the organs such as heart, liver, lungs, kidney, spleen, brain, adrenal gland, thymus, thyroid, pancreas, uterus, ovary, testis, prostate are taken out and weighs, calculate organ coefficient (organ weights/body weight).With light microscopic, histological examination is carried out to above-mentioned internal organs and spinal cord, thymus, bladder, bone marrow (breastbone), duodenum, stomach, ileum, pancreas, hypophysis cerebri, optic nerve, lymph node, coton and rectal etc.
4, result of the test
The all rats of overview all do not show any abnormal conditions; Hematological examination, blood parameters inspection, urinate biochemical, urine routine, system postmortem and histopathologic examination, indices, compared with control animals, does not all have obvious difference.Therefore, Chinese medicine oral liquid of the present invention to SD rat without any toxic action, in view of 20 times of ratios of its behaviour dose, so can infer that to take be safe to this oral liquid for patient.
Embodiment 8
The clinical trial of the granule that embodiment 4-6 produces
(1), basic document is tested
The experimenter of this test provides by certain the People's Hospital of city second, this institute from February, 2010 to 2013 year 12 monthly mortgages accept Enterozoa patient 346 for medical treatment, therefrom filter out 160 to be applicable to and the patient agreeing to do clinical trial, suffer from one or more in the parasites such as ascarid, ancylostome, pinworm, cestode, whipworm, infusorian respectively, wherein man 92, age 7-39 year, female 68, age 8-41 year; All experimenters suffered from parasitic kind be divided into 4 groups according to sex, institute, is numbered matched group respectively, test 1, test 2, test 3 groups.
(2), tested medicine
Matched group: albendazole tablet, the accurate word H42020816 of traditional Chinese medicines, Hubei Zhong Jia pharmaceutcal corporation, Ltd.
The granule that test group: embodiment of the present invention 4-6 produces.
(3), test method
Matched group oral albendazole sheet, every day 2 times, each 400mg, within less than 12 years old, child reduces by half; The granule that the oral embodiment of the present invention 4-6 of test group 1-3 group difference produces, every day 2 times, it is 7.2g/ days that each 20g(amounts to crude drug content), the child of less than 12 years old reduces by half and takes, it within 1 week, is a course for the treatment of, take medicine continuously 3 courses for the treatment of, the sign change of record experimenter, state of an illness recovery situation and untoward reaction etc.
(4), evaluation methodology
Cure: Enterozoa all kills discharge, and related symptoms all disappears, and makes a definite diagnosis fully recover through doctor.
Effective: Enterozoa does not all kill, related symptoms partial disappearance or improvement, still needs further treatment.
Invalid: intestinal parasitical diseases related symptoms is without any improvement, even more serious.
Untoward reaction: patient when according to dosage positive common medicine, the adverse reaction irrelevant with made disease of appearance.
(5), result of the test statistical analysis:
Patient sign Statistical Comparison: the matched group xerostomia in various degree that had routine patient to occur, weak, dizzy, headache, the untoward reaction such as to feel sick, there is not any untoward reaction in test group; Matched group patient is after healing, the symptoms such as the original digestive system damage of health (diarrhoea, stomachache, vomiting etc.), emaciation and sallow complexion, weak unable, inappetence are improved not obvious, test group patient above-mentioned symptom after healing disappears substantially, has rosy cheeks, complexion takes a turn for the better, good, the digestive function of appetite recovers normal.
Test data record and analysis:
| Group | Case load | Cure (rate) | Effective | Invalid | Total effective rate | Untoward reaction |
| Matched group | 40 | 22（55.0%） | 13 | 5 | 87.5% | 6 |
| Test 1 | 40 | 37（92.5%） | 3 | 0 | 100% | 0 |
| Test 2 | 40 | 35（87.5%） | 5 | 0 | 100% | 0 |
| Test 3 | 40 | 38（95.0%） | 2 | 0 | 100% | 0 |
(6), conclusion (of pressure testing)
Result of the test shows: from patient sign comparing result, Chinese medicine preparation of the present invention has significant treatment advantage in untoward reaction, double conditioning two of curing the disease; From analysis of statistical data result, the average cure rate of Chinese medicine preparation of the present invention is 91.7%, and higher than matched group 36.7 percentage points, average total effective rate is 100%, higher than matched group 12.5 percentage points.Therefore, compared with prior art, the present invention has very significant technical advantage in treatment Enterozoa, achieves beat all technique effect.
Claims (6)
1. treat a Chinese medicine preparation for Enterozoa, it is characterized in that, described preparation is made up of the raw material of following weight portion:
Fructus Mume 15-25 part Fructus Toosendan 6-14 part Fructus Carpesii 10-20 part Semen Arecae 15-29 part
Omphalia 14-26 part Fructus Aurantii 8-18 part Cortex Phellodendri 7-15 part Rhizoma Atractylodis 9-19 part
Rhizoma Atractylodis Macrocephalae 9-17 part Fructus Quisqualis 9-19 part Radix Aucklandiae 7-13 part Semen Torreyae core 12-24 part
Rhizoma Zingiberis 6-14 part Fructus Zanthoxyli 7-15 part Ramulus Cinnamomi 7-17 part Fructus Crataegi 8-20 part
Spina Gleditsiae 5-10 part Radix Glycyrrhizae 8-16 part.
2. a kind of Chinese medicine preparation for the treatment of Enterozoa according to claim 1, is characterized in that, described preparation is made up of the raw material of following weight portion:
Fructus Mume 20 parts of Fructus Toosendans 10 portions of Fructus Carpesiis 15 portions of Semen Arecaes 22 parts
Omphalia 20 parts of Fructus Aurantiis 13 portions of Cortex Phellodendris 11 parts of Rhizoma Atractylodis 14 parts
The Rhizoma Atractylodis Macrocephalae 13 parts of Fructus Quisqualis 14 parts of Radix Aucklandiae 10 parts of Semen Torreyae core 18 parts
Rhizoma Zingiberis 10 portions of Fructus Zanthoxylis 11 parts of Ramulus Cinnamomi 12 portions of Fructus Crataegis 14 parts
12 parts, Spina Gleditsiae 7 portions of Radix Glycyrrhizaes.
3. a kind of Chinese medicine preparation for the treatment of Enterozoa according to claim 1, is characterized in that, described preparation is made up of the raw material of following weight portion:
Fructus Mume 22 parts of Fructus Toosendans 9 portions of Fructus Carpesiis 17 portions of Semen Arecaes 24 parts
Omphalia 19 parts of Fructus Aurantiis 12 portions of Cortex Phellodendris 10 parts of Rhizoma Atractylodis 15 parts
The Rhizoma Atractylodis Macrocephalae 14 parts of Fructus Quisqualis 12 parts of Radix Aucklandiae 9 parts of Semen Torreyae core 19 parts
Rhizoma Zingiberis 11 portions of Fructus Zanthoxylis 13 parts of Ramulus Cinnamomi 11 portions of Fructus Crataegis 12 parts
13 parts, Spina Gleditsiae 9 portions of Radix Glycyrrhizaes.
4. a kind of Chinese medicine preparation for the treatment of Enterozoa according to claim 1, is characterized in that, described preparation is made up of the raw material of following weight portion:
Fructus Mume 19 parts of Fructus Toosendans 11 portions of Fructus Carpesiis 16 portions of Semen Arecaes 23 parts
Omphalia 22 parts of Fructus Aurantiis 14 portions of Cortex Phellodendris 12 parts of Rhizoma Atractylodis 12 parts
The Rhizoma Atractylodis Macrocephalae 11 parts of Fructus Quisqualis 15 parts of Radix Aucklandiae 11 parts of Semen Torreyae core 17 parts
Rhizoma Zingiberis 9 portions of Fructus Zanthoxylis 10 parts of Ramulus Cinnamomi 11 portions of Fructus Crataegis 13 parts
11 parts, Spina Gleditsiae 8 portions of Radix Glycyrrhizaes.
5., according to the arbitrary described a kind of Chinese medicine preparation for the treatment of Enterozoa of claim 1-4, it is characterized in that, the preparation technology of described preparation is following steps:
Step 1, accurately take each taste raw medicinal material in prescription ratio, pulverize respectively, for subsequent use;
Step 2, ingredients to be mixed, add 6-11 purified water doubly, soak 12-24 hour, backflow decocts 2-4 hour, filter, add the purified water of 4-7 times of weight again, backflow decocts 1-3 hour, filters (reservation filtering residue), by twice filtrate mixing, distillation and concentration is to relative density 1.10-1.15(65-75 DEG C of survey), be water extracting liquid, for subsequent use;
Step 3, the filtering residue of step (2) is added the edible ethanol solution of the 60-75% of 6-9 times of weight, backflow decocts 2-4 hour, filters, and once, by twice filtrate mixing, ethanol is gone out in distilling under reduced pressure, is alcohol extraction concentrated solution, for subsequent use in repetitive operation;
Step 4, mixed with alcohol extraction concentrated solution by water extracting liquid, distilling under reduced pressure, being concentrated into relative density is 1.25-1.35(55-65 DEG C of survey), be Chinese medical concrete;
Chinese medical concrete is made the finished product preparation of clinical needs by step 5, the modern general Chinese medicine preparation technology of utilization.
6., according to the arbitrary described a kind of Chinese medicine preparation for the treatment of Enterozoa of claim 1-4, it is characterized in that, described Chinese medicine preparation can make capsule, tablet, pill, granule, powder or syrup.
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| CN115671193A (en) * | 2022-12-07 | 2023-02-03 | 甘肃省畜牧兽医研究所 | Chinese herbal medicine composition for preventing and treating digestive tract diseases of midnight-noon black goats and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105012609A (en) * | 2015-07-29 | 2015-11-04 | 青岛蓝盛洋医药生物科技有限责任公司 | Traditional Chinese medicine preparation for treating pediatric intestinal parasite diseases and preparation method thereof |
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| CN106109793A (en) * | 2016-06-27 | 2016-11-16 | 陆川县珊罗镇振兴猪场 | A kind of Chinese medicine preparation treating pig endoparasite and preparation method thereof |
| CN115671193A (en) * | 2022-12-07 | 2023-02-03 | 甘肃省畜牧兽医研究所 | Chinese herbal medicine composition for preventing and treating digestive tract diseases of midnight-noon black goats and preparation method thereof |
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Application publication date: 20150408 |