CN105079392A - Preparation for treating ischialgia and preparation method thereof - Google Patents
Preparation for treating ischialgia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a preparation for treating ischialgia. The preparation is prepared from the following active pharmaceutical ingredients in parts by weight: 8-16 parts of fructus aurantii, 10-13 parts of cordyline terminalis, 9-12 parts of jasminum grandiflorum, 3-6 parts of rosa rugosa, 8-13 parts of wood betony, 6-12 parts of ivy glorybind herb or root, 8-14 parts of crossostephium chinense (L.) Makino, 10-15 parts of hairystalk loosestrife herb, 12-17 parts of figwort, 9-15 parts of vicia amoena Fisch. ex DC., 7-13 parts of peltate yam rahizome, 6-12 parts of black medick, 8-15 parts of sharptooth incarvillea rhizome and herb, 10-14 parts of aster tagasagomontanus, 8-12 parts of mulberry fruit and 9-14 parts of root of bilobed grewia. The preparation has functions of warming channels to dredge collaterals, dispelling wind to eliminate dampness, activating blood circulation to relieve pain, strengthening muscles and bones, and benefitting qi and blood; the effect of treating ischialgia is remarkable; all the selected active pharmaceutical ingredients are traditional Chinese herbs, so that the preparation is free from any toxic and side effects.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation for the treatment of sciatica and preparation method thereof.
Background technology
Sciatica is the syndrome based on sciatic nerve pathway and distributed areas pain.Most cases of sciatica are that the pathological changes being secondary to sciatic nerve local and surrounding structure is oppressed and infringement sciatic stimulation, are called secondary sciatica; Minority system constitutional, i.e. sciatic neuritis.Sciatica is the symptom caused because sciatic nerve is oppressed.Sciatic nerve is made up of several different spinal nerves, comprise the 4th, fifth lumbar nerve and first to the 3rd group neural.This nerve, by waist, through buttocks, stretches to back of thighs, shank and foot.When sciatic nerve is subject to oppressing, this nerve just there will be pain, causes the symptom of sciatica.Although sciatic nerve comes from waist, sciatica patient is many can not complain lumbago.It is outer then that pain is more common in arm, thigh or shank.
Sciatica is divided into former and secondary two kinds.Primary sciatica is otherwise known as constitutional sciatic neuritis, and how to be caused by sciatic inflammation, be common with one-sided morbidity.Principal pathogenetic reason is that other inflammation foci such as cold wet and tonsillitis, prostatitis, gingivitis, sinusitis infect, the myositis that occurs together the while of some and fibromyositis.Secondary Sciatic Pain causes due to the compressing of adjacent lesion or stimulation, is divided into again root and dryness sciatica, refers to that pressurized position is in nerve root or in nerve trunk respectively.Root is common, and the cause of disease is the most common with intervertebral disk hernia; Dryness can caused by sacroiliitis, basin intracavitary neoplasm, gravid uterus compressing, coxitis, buttocks wound, diabetes etc.Primary disease belongs to motherland's medical science " arthromyodynia " category, and its pathogenesis is the exopathogen such as wind, cold, wet, heat invasion and attack human bodies, impatency meridians, and caused by QI-blood circulation is smooth, control suitable dredging the meridian, expelling wind and removing dampness, dispelling cold by warming the meridian is main.
Application publication number CN103893295A(application number 201210583785.0) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of sciatica, Radix Aconiti Preparata 8-10 gram is made by the raw material of following weight grams, Radix Aconiti Kusnezoffii Preparata 8-10 gram, Cortex Moutan 6-8 gram, Radix Paeoniae Rubra 6-8 gram, Herba Asari 12-15 gram, Rhizoma Atractylodis 8-12 gram, Radix Stephaniae Tetrandrae 10-12 gram, Rhizoma Chuanxiong 12-15 gram, Radix Glycyrrhizae 4-6 gram, Ramulus Cinnamomi 8-12 gram.Application publication number CN102973752A(application number 201210516624.X) Chinese invention patent document disclose a kind of medicine for the treatment of sciatica, mixed by weight by following raw materials according: Rhizoma Arisaematis (processed) 7-12 gram, Radix Angelicae Dahuricae 8-13 gram, Cortex Phellodendri 9-13 gram, Rhizoma Chuanxiong 8-12 gram, Flos Carthami 8-12 gram, Rhizoma alpiniae chinensis 7-11 gram, Radix Clematidis 22-27 gram, Rhizoma Atractylodis 12-18 gram, Semen Persicae 13-18 gram, Radix Stephaniae Tetrandrae 12-18 gram, Rhizoma Corydalis 14-16 gram, Radix Angelicae Pubescentis 13-17 gram, Radix Gentianae 4-7 gram, Massa Medicata Fermentata 10-13 gram, Ramulus Cinnamomi 10-14 gram.Application publication number CN104274548A(application number 201310296930.1) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of sciatica, configured by the raw material of Chinese medicine of following parts by weight and form: Radix Angelicae Sinensis 10-20 part, Ramulus Cinnamomi 10-15 part, Radix Paeoniae Alba 25-35 part, Herba Asari 5-10 part, Medulla Tetrapanacis 5-10 part, Aconitum carmichjaelii Debx. 8-15 part processed, Radix Glycyrrhizae 5-10 part, Radix Clematidis 10-20 part.
The therapeutic advance of current Western medicine aspect is comparatively slow, and general Therapeutic Method is for lying up, using analgesic and hormone etc.The research of Chinese traditional treatment is in recent years day by day deep, in treatment by Chinese herbs, acupuncture and moxibustion therapy, massage treatment etc., all achieve good clinical effectiveness.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, that sciatica is treated in effect rapidly, safely and effectively preparation.Invention formulation determined curative effect, is convenient to Clinical practice.
Technical scheme of the present invention is:
The preparation for the treatment of sciatica, is prepared from by following bulk drugs, is weight portion: Fructus Aurantii 8-16; Ti 10-13; Flos jasmini 9-12; Flos Rosae Davuricae 3-6; Herba Stachydis Japonicae 8-13; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6-12; Chinese mugwort 8-14 in thousand; Herba lysimachiae capillipedis 10-15; Radix Scrophulariae 12-17; Herba Viciae Amoenae 9-15; Nine sons are not from female 7-13; Herba Medicaginis Lupulinae 6-12; Suona horn flower 8-15; RADIX ET RHIZOMA LIGULARIAE 10-14; Fructus Mori 8-12; Radix grewiae bilobae 9-14.
In preferred scheme, Fructus Aurantii 10-14; Ti 11-12; Flos jasmini 10-11; Flos Rosae Davuricae 4-5; Herba Stachydis Japonicae 9.5-11.5; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 8-10; Chinese mugwort 10-12 in thousand; Herba lysimachiae capillipedis 11-14; Radix Scrophulariae 13.5-15.5; Herba Viciae Amoenae 11-13; Nine sons are not from female 9-11; Herba Medicaginis Lupulinae 8-10; Suona horn flower 10-13; RADIX ET RHIZOMA LIGULARIAE 11-13; Fructus Mori 9-11; Radix grewiae bilobae 10.5-12.5.
Be more preferably, Fructus Aurantii 12; Ti 11.5; Flos jasmini 10.5; Flos Rosae Davuricae 4.5; Herba Stachydis Japonicae 10.5; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 9; Chinese mugwort 11 in thousand; Herba lysimachiae capillipedis 12.5; Radix Scrophulariae 14.5; Herba Viciae Amoenae 12; Nine sons are not from female 10; Herba Medicaginis Lupulinae 9; Suona horn spends 11.5; RADIX ET RHIZOMA LIGULARIAE 12; Fructus Mori 10; Radix grewiae bilobae 11.5.
The preparation for the treatment of sciatica, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Flos jasmini and Flos Rosae Davuricae are cleaned respectively, are together placed in parch container, and intense fire heats, stir-baked the crude drugs into black on outside and brown in inside, take out, cool, grind into powder, for subsequent use;
(2) ti shave is placed in Sucus Zingberis and soaks 12-18 minute (be preferably placed in Sucus Zingberis soak 15 minutes), and take out, be not together placed in frying pan with Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Stachydis Japonicae and nine sons from mother, moderate heat heats, and stir-frying to buff is degree, and taking-up cools, for subsequent use;
(3) Fructus Mori and Herba Viciae Amoenae are placed in Chinese medicine pan, and add the clear water slow fire boiling 15-35 minute clear water slow fire boiling of 4 times amount (preferably add 25 minutes) of 3.5-4.5 times amount, filter, filtrate is for subsequent use;
(4) crude drug and Fructus Aurantii after step (2) being processed, within thousand, end, Herba lysimachiae capillipedis, Radix Scrophulariae, Herba Medicaginis Lupulinae, suona horn are colored, RADIX ET RHIZOMA LIGULARIAE and Radix grewiae bilobae are together placed in Chinese medicine pan, add clear water and be placed in powder 3-5cm, slow fire heating decoction twice, first time decocts 22-40 minute (preferably first time decocts 30 minutes), second time decocts 10-18 minute (preferably second time decocts 14 minutes), merge twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (3) and (4) gained filtrate are merged, add the crude drug after step (1) process, continue slow fire boiling 10-20 minute (preferably continuing slow fire boiling 15 minutes), three aspect filtered through gauze, dry heat sterilization, encapsulation, to obtain final product.
The preparation method of the decoction of above-mentioned treatment sciatica, preferred scheme is, in step (3), the temperature of dry heat sterilization is 88-102 DEG C (temperature of preferred dry heat sterilization is 92-98 DEG C, and the temperature of the dry heat sterilization be more preferably is 95 DEG C).
The preparation method of the decoction of above-mentioned treatment sciatica, preferred scheme is, in step (3), the time of dry heat sterilization is 16-30 minute (time of preferred dry heat sterilization is 20-26 minute, and the time of the dry heat sterilization be more preferably is 23 minutes).
The preparation method of described capsule is:
(1) Fructus Aurantii removes flesh, and with Fructus Gleditsia water soaking 2-4 days of 3-4 times of raw material dose the Fructus Gleditsia water soaking of 3.5 times of raw material doses (preferably use 3 days), take out, be placed on tile with Ai Yitong in thousand, intense fire heats, and dries, cools, smash into fine powder to pieces, for subsequent use;
(2) Flos jasmini and Flos Rosae Davuricae are cleaned respectively, add the Mel (preferably adding the Mel of 0.35 times of raw material dose) of 0.25-0.45 times of raw material dose, mix thoroughly, vexed 6-10 minute (preferably vexed 8 minutes), take out, slow fire heats, and frying extremely tack-free is degree, dry, smash into fine powder to pieces, for subsequent use;
(3) Chinese medicine water extraction is not adopted to extract from female and RADIX ET RHIZOMA LIGULARIAE ti, Herba Stachydis Japonicae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Radix Scrophulariae, Fructus Mori, nine sons, with the cold water of 6-8 times of raw material dose for solvent (preferably with the cold water of 7 times of raw material doses for solvent), slow fire heating extraction twice, first time extracts 30-40 minute (preferably first time extracts 35 minutes), second time is extracted 15-25 minute (preferably second time is extracted 20 minutes), merges twice Aqueous extracts, filters, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) Herba lysimachiae capillipedis, Herba Viciae Amoenae, Herba Medicaginis Lupulinae, suona horn flower and Radix grewiae bilobae are placed in Chinese medicine dehydrator, in 45-65 DEG C of dry 38-60 minute (being preferable over 55 DEG C of dryings 50 minutes), taking out, pulverize into fine powder, for subsequent use;
(5) joined in step (3) gained thick paste by the raw material medicated powder after step (1), (2) and (4) process, add sucrose fine and cross-linked cellulose while stirring, mixing, granulate, dry, granulate, incapsulates shell, to obtain final product.
The preparation method of described granule is:
(1) get thousand Chinese mugwort and Herba Viciae Amoenae be placed in Chinese medicine baking oven, in 60-80 DEG C of dry 20-30 minute (being preferable over 70 DEG C of dryings 25 minutes), taking-up, be placed in pulverizer and be ground into fine powder, for subsequent use;
(2) Fructus Aurantii, ti, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Stachydis Japonicae and Radix Scrophulariae are placed in the wheat bran made popular, continue slow fire heating, when being coke yellow to wheat bran, take out, sieve the wheat bran that defocuses, cool, for subsequent use;
(3) Flos jasmini, Flos Rosae Davuricae, Herba lysimachiae capillipedis and Herba Medicaginis Lupulinae are placed in hermetic container, the yellow wine adding 1.5-3.5 times amount is mixed thoroughly (yellow wine preferably adding 2.5 times amount is mixed thoroughly), adds a cover stewing 4-8 minute (preferably adding a cover stewing 6 minutes), takes out, for subsequent use;
(4) crude drug after step (2) and (3) process and nine sons are not together placed in frying pan from mother, suona horn flower, RADIX ET RHIZOMA LIGULARIAE, Fructus Mori and Radix grewiae bilobae, add clear water and do not have powder 3-4cm, big fire heated and boiled, turn little fire to decoct 35-55 minute (preferably turning little fire to decoct 45 minutes), filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.18-1.20, spraying dry, get dry extract powder, for subsequent use;
(5) crude drug after step (1) being processed mixes with step (4) gained dried cream powder, is placed in granulator and granulates, and dry, granulate, subpackage, to obtain final product.
The preparation method of described powder is:
(1) Fructus Mori smashs into pureed to pieces, with ti, Herba Stachydis Japonicae, within thousand, to end and Radix grewiae bilobae is together placed in traditional Chinese medicine drying device, in 55-65 DEG C of dry 35-55 minute (being preferable over 60 DEG C of dryings 45 minutes), taking out, grinds as fine powder, for subsequent use;
(2) get Fructus Aurantii, Radix Scrophulariae, suona horn flower and RADIX ET RHIZOMA LIGULARIAE mixing, the saline solution adding 15%-25% is mixed thoroughly (saline solution preferably adding 20% is mixed thoroughly), and moistening is sucked to saline solution, takes out, and slow fire heating fried dry is degree, and taking-up cools, and smashs into fine powder to pieces, for subsequent use;
(3) by the crude drug except step (1) and (2), pulverizing respectively, be placed in the penetrating bag of Chinese medicine, take ethanol as solvent, reflux, extract, twice, each respectively extraction 12-20 minute (preferably each each extraction 16 minutes), merges twice alcohol extract, filtration, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20-1.23, and vacuum drying gets dry extract powder, for subsequent use;
(4) the crude drug mixing after being processed step (1)-(3), sterilizing encapsulates, and to obtain final product.
The preparation method of the powder of above-mentioned treatment sciatica, preferred scheme is, in step (3), the amount of solvent is the 3.5-7.5 of raw material dose doubly (amount of preferred solvent is 4.5-6.5 times of raw material dose, and the amount of the solvent be more preferably is 5.5 times of raw material dose).
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,gained medicine of the present invention has promoting the flow of QI in the collateral by warming the meridian, expelling wind and removing dampness, promoting blood circulation and stopping pain, strengthening bone and muscle, the effect that fills blood, and have significant curative effect to treatment sciatica, selected materials is all Chinese medicine material, without any side effects;
3,medicine of the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the preparation for the treatment of sciatica, is prepared from by following bulk drugs, is weight portion (50g/ part): Fructus Aurantii 8 parts; Ti 10 parts; Flos jasmini 9 parts; Flos Rosae Davuricae 3 parts; Herba Stachydis Japonicae 8 parts; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6 parts; Chinese mugwort 8 parts in thousand; Herba lysimachiae capillipedis 10 parts; Radix Scrophulariae 12 parts; Herba Viciae Amoenae 9 parts; Nine sons are not from female 7 parts; Herba Medicaginis Lupulinae 6 parts; Suona horn spends 8 parts; RADIX ET RHIZOMA LIGULARIAE 10 parts; Fructus Mori 8 parts; Radix grewiae bilobae 9 parts.
The preparation method of the decoction for the treatment of sciatica is:
(1) Flos jasmini and Flos Rosae Davuricae are cleaned respectively, are together placed in parch container, and intense fire heats, stir-baked the crude drugs into black on outside and brown in inside, take out, cool, grind into powder, for subsequent use;
(2) ti shave is placed in Sucus Zingberis immersion 12 minutes, takes out, is not together placed in frying pan with Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Stachydis Japonicae and nine sons from mother, and moderate heat heats, and stir-frying to buff is degree, and taking-up cools, for subsequent use;
(3) Fructus Mori and Herba Viciae Amoenae are placed in Chinese medicine pan, add the clear water slow fire boiling 15 minutes of 3.5 times amount, and filter, filtrate is for subsequent use;
(4) crude drug and Fructus Aurantii after step (2) being processed, within thousand, end, Herba lysimachiae capillipedis, Radix Scrophulariae, Herba Medicaginis Lupulinae, suona horn are colored, RADIX ET RHIZOMA LIGULARIAE and Radix grewiae bilobae are together placed in Chinese medicine pan, add clear water and be placed in powder 3-5cm, slow fire heating decoction twice, first time decocts 22 minutes, second time decocts 10 minutes, merge twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (3) and (4) gained filtrate merged, add the crude drug after step (1) process, continue slow fire boiling 10 minutes, three aspect filtered through gauze, 88 DEG C of dry heat sterilizations 16 minutes, encapsulation, to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 100-120mL, warmly takes, 7 days courses for the treatment of.
embodiment 2the preparation for the treatment of sciatica, is prepared from by following bulk drugs, is weight portion (30g/ part): Fructus Aurantii 16 parts; Ti 13 parts; Flos jasmini 12 parts; Flos Rosae Davuricae 6 parts; Herba Stachydis Japonicae 13 parts; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 12 parts; Chinese mugwort 14 parts in thousand; Herba lysimachiae capillipedis 15 parts; Radix Scrophulariae 17 parts; Herba Viciae Amoenae 15 parts; Nine sons are not from female 13 parts; Herba Medicaginis Lupulinae 12 parts; Suona horn spends 15 parts; RADIX ET RHIZOMA LIGULARIAE 14 parts; Fructus Mori 12 parts; Radix grewiae bilobae 14 parts.
The preparation method of the capsule for the treatment of sciatica is:
(1) Fructus Aurantii removes flesh, and with the Fructus Gleditsia water soaking 3 days of 3.5 times of raw material doses, take out, be placed on tile with Ai Yitong in thousand, intense fire heats, and dries, cools, smash into fine powder to pieces, for subsequent use;
(2) Flos jasmini and Flos Rosae Davuricae are cleaned respectively, add the Mel of 0.35 times of raw material dose, mix thoroughly, vexed 8 minutes, take out, and slow fire heats, and frying extremely tack-free is degree, dries, smashs into fine powder to pieces, for subsequent use;
(3) Chinese medicine water extraction is not adopted to extract from female and RADIX ET RHIZOMA LIGULARIAE ti, Herba Stachydis Japonicae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Radix Scrophulariae, Fructus Mori, nine sons, with the cold water of 7 times of raw material doses for solvent, slow fire heating extraction twice, first time extracts 35 minutes, second time is extracted 20 minutes, merges twice Aqueous extracts, filters, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) Herba lysimachiae capillipedis, Herba Viciae Amoenae, Herba Medicaginis Lupulinae, suona horn flower and Radix grewiae bilobae are placed in Chinese medicine dehydrator, in 55 DEG C of dryings 50 minutes, take out, pulverize into fine powder, for subsequent use;
(5) joined in step (3) gained thick paste by the raw material medicated powder after step (1), (2) and (4) process, add sucrose fine and cross-linked cellulose while stirring, mixing, granulate, dry, granulate, incapsulates shell, to obtain final product.
The instructions of taking of gained capsule of the present invention is: every day three times, each 4-5 grain, and warm water takes, 7 days courses for the treatment of.
Model case: XX recklessly, man, 47 years old, the new village people in Henan, patient's readme: occurred left lower extremity pain, numbness, weak without obvious inducement before 2 months, pain emits to foot from buttocks on rear side of thigh always, pain increases the weight of when activity, slightly alleviates during rest, gives the expectant treatments such as physical therapy at local hospital, above-mentioned symptom without alleviation, difficulty in walking.Patient goes to my institute's treatment on August 22nd, 2011.Check: its pain, after left side lumbosacral region to the right lower limb, outside reaches shank and dorsal portion, right large limb joint stuffiness, can not sitting, and after movable, the pain increased, takes the photograph the inspection such as sheet, CT scan, anti-" O ", be diagnosed as sciatica through x-ray.
Take the capsule of the present embodiment gained treatment sciatica, instructions of taking: every day three times, each 4-5 grain, warm water takes, 7 days courses for the treatment of.After treating two courses for the treatment of, patient's cardinal symptom obviously alleviates, spirit can, sleep good; Again after two courses for the treatment of of continual cure, pain and other symptom all disappear, and lab testing recovers normal substantially, and patient's self-induction is fully recovered, and drug withdrawal is followed up a case by regular visits to after half a year, without recurrence.
embodiment 3the preparation for the treatment of sciatica, is prepared from by following bulk drugs, is weight portion (45g/ part): Fructus Aurantii 10 parts; Ti 11 parts; Flos jasmini 10 parts; Flos Rosae Davuricae 4 parts; Herba Stachydis Japonicae 9.5 parts; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 8 parts; Chinese mugwort 10 parts in thousand; Herba lysimachiae capillipedis 11 parts; Radix Scrophulariae 13.5 parts; Herba Viciae Amoenae 11 parts; Nine sons are not from female 9 parts; Herba Medicaginis Lupulinae 8 parts; Suona horn spends 10 parts; RADIX ET RHIZOMA LIGULARIAE 11 parts; Fructus Mori 9 parts; Radix grewiae bilobae 10.5 parts.
The preparation method of the granule for the treatment of sciatica is:
(1) get thousand Chinese mugwort and Herba Viciae Amoenae be placed in Chinese medicine baking oven, in 70 DEG C of dryings 25 minutes, taking-up, be placed in pulverizer and be ground into fine powder, for subsequent use;
(2) Fructus Aurantii, ti, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Stachydis Japonicae and Radix Scrophulariae are placed in the wheat bran made popular, continue slow fire heating, when being coke yellow to wheat bran, take out, sieve the wheat bran that defocuses, cool, for subsequent use;
(3) Flos jasmini, Flos Rosae Davuricae, Herba lysimachiae capillipedis and Herba Medicaginis Lupulinae are placed in hermetic container, the yellow wine adding 2.5 times amount is mixed thoroughly, adds a cover stewing 6 minutes, takes out, for subsequent use;
(4) crude drug after step (2) and (3) process and nine sons are not together placed in frying pan from mother, suona horn flower, RADIX ET RHIZOMA LIGULARIAE, Fructus Mori and Radix grewiae bilobae, add clear water and do not have powder 3-4cm, big fire heated and boiled, turn little fire to decoct 45 minutes, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.18-1.20, spraying dry, get dry extract powder, for subsequent use;
(5) crude drug after step (1) being processed mixes with step (4) gained dried cream powder, is placed in granulator and granulates, and dry, granulate, subpackage, to obtain final product.
The instructions of taking of gained granule of the present invention is: every day three times, each 15-20g, and warm water is taken after mixing it with water, 7 days courses for the treatment of.
embodiment 4the preparation for the treatment of sciatica, is prepared from by following bulk drugs, is weight portion (35g/ part): Fructus Aurantii 14 parts; Ti 12 parts; Flos jasmini 11 parts; Flos Rosae Davuricae 5 parts; Herba Stachydis Japonicae 11.5 parts; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 10 parts; Chinese mugwort 12 parts in thousand; Herba lysimachiae capillipedis 14 parts; Radix Scrophulariae 15.5 parts; Herba Viciae Amoenae 13 parts; Nine sons are not from female 11 parts; Herba Medicaginis Lupulinae 10 parts; Suona horn spends 13 parts; RADIX ET RHIZOMA LIGULARIAE 13 parts; Fructus Mori 11 parts; Radix grewiae bilobae 12.5 parts.
The preparation method of the powder for the treatment of sciatica is:
(1) Fructus Mori smashs into pureed to pieces, with ti, Herba Stachydis Japonicae, within thousand, to end and Radix grewiae bilobae is together placed in traditional Chinese medicine drying device, in 60 DEG C of dryings 45 minutes, takes out, grinds as fine powder, for subsequent use;
(2) get Fructus Aurantii, Radix Scrophulariae, suona horn flower and RADIX ET RHIZOMA LIGULARIAE mixing, the saline solution adding 20% is mixed thoroughly, and moistening is sucked to saline solution, takes out, and slow fire heating fried dry is degree, and taking-up cools, and smashs into fine powder to pieces, for subsequent use;
(3) by the crude drug except step (1) and (2), pulverize respectively, be placed in the penetrating bag of Chinese medicine, take ethanol as solvent, the amount of solvent is 5.5 times of raw material dose, reflux, extract, twice, each each extraction 16 minutes, merge twice alcohol extract, filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20-1.23, vacuum drying gets dry extract powder, for subsequent use;
(4) the crude drug mixing after being processed step (1)-(3), sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained powder of the present invention is: every day three times, each 7-10g, and hot water is taken after mixing it with water, 7 days courses for the treatment of.
Model case: Cui XX, female, 55 years old, people from Binzhou.Patient suffers from sciatica at examination in hospital the year before, is ached to heel, a burst of aggravation by lower waist, as acupuncture is burning hot, can not to walk or uprightly.Apply acupuncture at local hospital, the treatment such as massage, symptom has no alleviation, after once took special prescription of Chinese herbal medicine treatment, symptom has no alleviation, and within nearly two months, conditions of patients increases the weight of, and can only lie in bed stiff.After being introduced, have the attitude of trying in arms, come my institute on June 12nd, 2013 and check treatment, check: patient pain is on rear side of buttocks thigh, and after shank, outside is radiated to sufficient lateral part; Limb adynamia, numbness, check through lumbar vertebra CT, MRI etc. and be diagnosed as sciatica.
Take the powder of the present embodiment gained treatment sciatica, instructions of taking: every day three times, each 7-10g, hot water is taken after mixing it with water, 7 days courses for the treatment of.After treating two courses for the treatment of, patient pain's symptom obviously alleviates; After two courses for the treatment of of continual cure, limb activity is normal, and other malaise symptoms disappears, and self-induction is cured.Drug withdrawal is paid a return visit after half a year, and patient body is healthy, without recurrence.
embodiment 5the preparation for the treatment of sciatica, is prepared from by following bulk drugs, is weight portion (40g/ part): Fructus Aurantii 12 parts; Ti 11.5 parts; Flos jasmini 10.5 parts; Flos Rosae Davuricae 4.5 parts; Herba Stachydis Japonicae 10.5 parts; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 9 parts; Chinese mugwort 11 parts in thousand; Herba lysimachiae capillipedis 12.5 parts; Radix Scrophulariae 14.5 parts; Herba Viciae Amoenae 12 parts; Nine sons are not from female 10 parts; Herba Medicaginis Lupulinae 9 parts; Suona horn spends 11.5 parts; RADIX ET RHIZOMA LIGULARIAE 12 parts; Fructus Mori 10 parts; Radix grewiae bilobae 11.5 parts.
The preparation method of the decoction for the treatment of sciatica is:
(1) Flos jasmini and Flos Rosae Davuricae are cleaned respectively, are together placed in parch container, and intense fire heats, stir-baked the crude drugs into black on outside and brown in inside, take out, cool, grind into powder, for subsequent use;
(2) ti shave is placed in Sucus Zingberis immersion 15 minutes, takes out, is not together placed in frying pan with Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Stachydis Japonicae and nine sons from mother, and moderate heat heats, and stir-frying to buff is degree, and taking-up cools, for subsequent use;
(3) Fructus Mori and Herba Viciae Amoenae are placed in Chinese medicine pan, add the clear water slow fire boiling 25 minutes of 4 times amount, and filter, filtrate is for subsequent use;
(4) crude drug and Fructus Aurantii after step (2) being processed, within thousand, end, Herba lysimachiae capillipedis, Radix Scrophulariae, Herba Medicaginis Lupulinae, suona horn are colored, RADIX ET RHIZOMA LIGULARIAE and Radix grewiae bilobae are together placed in Chinese medicine pan, add clear water and be placed in powder 3-5cm, slow fire heating decoction twice, first time decocts 30 minutes, second time decocts 14 minutes, merge twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (3) and (4) gained filtrate merged, add the crude drug after step (1) process, continue slow fire boiling 15 minutes, three aspect filtered through gauze, 95 DEG C of dry heat sterilizations 23 minutes, encapsulation, to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 100-120mL, warmly takes, 7 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Aurantii: base is former: this product is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.Nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Effect: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Cure mainly: for the breast side of body stagnation of QI.Distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, uterine prolapse.
Ti: base is former: be leaf or the root of Agavaceae plant ti.Nature and flavor: sweet; Light; Be slightly cold.Effect: cooling blood for hemostasis; Dissipating blood stasis analgesic therapy.Cure mainly hemoptysis; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Stomachache; Bones and muscles pain; Treating swelling and pain by traumatic injury.
Flos jasmini: base is former: be the dry flower of Oleaceae plants Flos jasmini.Chemical analysis:, gas aromatic person yellow with coloured gold is good.Containing linalool in Flos jasmini, phenylmethyl acetate, benzoic acid (Z)-3-vinyl acetate, LINL-OX, indole, jasmine lactone and methyl jasmonate.Congener Flos Jasmini alabastrum spends middle ingredient different with in full bloom.Main component in alabastrum is pohytol and linalool.The especially p-chavicol of aromatic compound is detected in open spending, also containing benzyl acetate in spending, and nerol, Geraniol, indole, 4-isopropyl acid methyl ester, hexenyl benzoate, trimethyl ten five-carbon ketone, isophytol, Cinnamyl Benzoate, acetic acid isophytol ester, Geraniol base Geraniol, acetic acid phytol ester and acetic acid Geraniol base Geraniol base Geraniol ester.Nature and flavor: micro-hardship; Property is put down.Gui Jing: Liver Channel.Function cures mainly: soothing liver-QI for relieving depression; Promoting the circulation of QI to relieve pain.Side of body rib gastral cavity abdomen caused by main stagnation of QI due to depression of the liver is had a pain; Dysentery is suffered from abdominal pain.
Flos Rosae Davuricae: base is former: be the flower of rosaceous plant Rosa bella.Nature and flavor: acid; Sweet; Flat.Gui Jing: liver; Spleen channel.Function cures mainly: regulating qi-flowing for harmonizing stomach; Cough-relieving.Main menoxenia, dysmenorrhea, metrorrhagia, spits blood, intercostal neuralgia, pulmonary tuberculosis cough.
Herba Stachydis Japonicae: base is former: be herb or the root of labiate Herba Stachydis Japonicae, magnificent Herba Stachydis Japonicae or Herba Stachydis.Nature and flavor: acrid in the mouth; Cool in nature.Gui Jing: return lung; Stomach warp.Function cures mainly: heat-clearing and toxic substances removing; Cough-relieving sore-throat relieving; Hemostasia and detumescence.Main flu; Acute filthy disease; Consumptive lung disease; Lung abscess; Wind syndrome of head is dizzy; Pharyngalgia; Between mistake; Spit blood; Spitting of blood; Epistaxis; Metrorrhagia; Dysentery; Stranguria; Treating swelling and pain by traumatic injury.
Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae): base is former: be herb or the root of dicotyledon scammonia section plant DAWANHUA.Chemical analysis: rhizome, containing anti-caprolactone, slaps leaf coculine.Leaf is containing Kaempferol-half lactoside.Nature and flavor: sweet micro-hardship; Flat.Gui Jing: liver; Kidney channel.Function cures mainly: spleen invigorating; Dampness removing; Regulating menstruation.Main weakness of the spleen and stomach; Dyspepsia; Infantile milk regurgitation; Infantile malnutrition; Five types of stranguria; Leukorrhagia; Menoxenia.
Chinese mugwort in thousand: base is former: be the leaf of feverfew Hibisci Mutabilis chrysanthemum.Nature and flavor: acrid in the mouth; Bitter; Slightly warm in nature.Function cures mainly: dispersing wind and cold; Reduce phlegm dampness removing; Removing toxic substances and promoting subsidence of swelling.Main anemofrigid cold; Cough with copious phlegm; Pertussis; Have loose bowels; Stranguria with turbid discharge; Leucorrhea; Carbuncle furunculosis.
Herba lysimachiae capillipedis: base is former: be the herb of Ofthe Primulaceae Herba lysimachiae capillipedis.Chemical analysis: leaf is containing a small amount of apigenin and luteolin etc.Nature and flavor: acrid in the mouth; Warm in nature.Function cures mainly: removing dampness keeps away turbid; Inducing diuresis to remove edema.Main summer-heat is aobvious vomits and diarrhoea; Edema; Dysuria.
Radix Scrophulariae: base is former: this product is the dry root of goatweed Radix Scrophulariae.Character: this product is class prop drawing shape, and centre is slightly thick or upper coarse and lower fine, some microbends.Surface lark or taupe, has irregular longitudinal furrow, hole skin sample projection of growing crosswise and sparse transverse crack and a mark of fibrous root.Nature and flavor: sweet, bitter, salty, are slightly cold.Gui Jing: return lung, stomach, kidney channel.Effect: removing heat from blood YIN nourishing, eliminating fire and detoxication.Cure mainly: for consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, and scrofula is sick, diphtheria, carbuncle sore tumefacting virus.
Herba Viciae Amoenae: base is former: be the young stem and leaf of leguminous plant Herba Viciae Amoenae.Nature and flavor: 1. " Chinese herbal medicine handbook is commonly used in northeast ": " sweetness and bitterness, temperature." 2. " the conventional Chinese herbal medicine handbook in the north ": " sweet, flat, nontoxic.”。Function cures mainly: wind-damp dispelling, invigorates blood circulation, relaxing muscles and tendons, pain relieving.Dispelling the wind and dampness pathogens pain, sprain and contusion are hindered, innominate toxic swelling, eczema scrotum.
Nine sons are not from mother: base is former: be the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Hypoglaucae.Chemical analysis: tuber contains diosgenin, Yamogenin.Rhizome is containing steroid, except diosgenin and Yamogenin, also have: △,-deoxidation Tigogenin, △-deoxidation neotigogenin, diosgenin palmitate, Yamogenin cetylate, different narthogenin, Yamogenin-3-O-β-D-Glucose glycoside, cupreol, smilagenin ketone, chinaroot greenbrier sapogenin ketone, table smilagenin, table chinaroot greenbrier sapogenin, Yamogenin 3-O-[α-L-rhamnopyranosyl (1 → 4) β-D-glucopyanoside].Nature and flavor: bitter; Micro-pungent; Be slightly cold.Function cures mainly: expelling wind and removing dampness; Removing obstruction in the collateral to relieve pain; Heat-clearing and toxic substances removing.Main air pain of dampness syndrome; Contracture is numb; Peratodynia; Jaundice due to damp-heat; Nebulousurine; Drench pain; Leucorrhea; Traumatic pain; Eczema toxic swelling; Rubella; Eczema; Venom.
Herba Medicaginis Lupulinae: base is former: be the herb of leguminous plant shamrock.Chemical analysis: herb is containing estrogen-like composition.Seed contains Saponin, galactose.Root and in spending containing multiple Saponin, as the hydrolysis of medicagenic acid glycoside obtains medicagenic acid, hederagenin and people's bean soap alcohol B, C, D, E, F etc.4 kinds of triterpenoid saponin, i.e. soyasaponinss are got again subsequently, hederagenin-3-O-β-D-glucopyanoside, medicagenic acid-3-O-β-D-glucopyanoside and the two glucopyanoside of medicagenic acid-3,28-from root.Hua Zhongshang contains flavone compound: larix sibirica flavone and its 5 '-O-β-D-Glucose glycoside, 3,5 '-O-β-D-diglucoside, 3,7,5 '-O-β-D-tri-glucose glycoside, the glycoside of nimbecetin, Quercetin and myricetin-3-O-glucoside.Aerial parts is containing carotene, vitamin C, vitamin B1, vitamin B2, pyridoxol, pantothenic acid and nicotinic acid.Nature and flavor: sweet; Bitter; Micro-puckery; Cool in nature; Mild toxicity.Gui Jing: lung; Liver; Gallbladder; Kidney channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Relaxing muscles and tendons and activating QI and blood in the collateral; Relieving cough and asthma; Removing pathogenic heat from blood and toxic substance from the body.Main jaundice due to damp-heat; Pyretic stranguria; Stone jaundice due to damp-heat; Pyretic stranguria; Stranguria caused by urinary stone; Rheumatic arthralgia; Cough with asthma; Hemorrhoidal bleeding; Finger furuncle; Venom.
Suona horn flower: base is former: be the band rhizome herb of Bignoniaceae tree planting thing Herba Melicae Scabrosae.Chemical analysis: leaf contains hentriacontane, ursolic acid, potassium chloride, 2-Ethoxymethylene-3,5-dihydroxy-y-pyrone.Pharmacological action: 1. antiinflammatory action: Herba Melicae Scabrosae chloroform extract 200mg/kg(is about 1/44 of median lethal dose(LD 50)) gavage, the mouse peritoneal caused by Dichlorodiphenyl Acetate, dimethylbenzene and histamine and capillary of skin permeability increase obvious inhibitory action; Also can obviously suppress rat paw edema caused by the mouse ear inflammation caused by Oleum Tiglii and Ovum Gallus domesticus album.2. antioxidation.Nature and flavor: bitter in the mouth; Micro-pungent; Property is put down.Function cures mainly: invigorating spleen to remove dampness; Promoting flow of QI and blood.Master has loose bowels; Dysentery; Stomachache; Hypochondriac pain; Rheumatalgia; Menoxenia; Carbuncle; Fracture.
RADIX ET RHIZOMA LIGULARIAE: base is former: be the root and rhizome of feverfew ligularia fischeri.Pharmacological action: to eliminate the phlegm, antitussive effect: the phenol red method experiment of mice, ligularia fischeri condensed water decoct 10g/kg gavage, has obvious phlegm-dispelling functions; Condensed water decoct 20g/kg, water decoction 6g/kg and volatile oil Emulsion 500g/kg gavage cause to cough to mice ammonia and all do not show obvious antitussive effect.Nature and flavor: acrid in the mouth; Slightly warm in nature.Function cures mainly: eliminate the phlegm; Cough-relieving; Vital energy regualting and blood circulation-promoting; Pain relieving.Main cough; General many asthma; Pertussis; Lumbago and skelalgia; Impairment caused by overstrain; Traumatic injury.
Fructus Mori: base is former: be the fruit ear of moraceae plants Mulberry.Pharmacological action: 1. strengthen the positive T lymphocyte of immunologic function mice α-naphthylacetate esterase (ANAE) and spleen bone-marrow-derived lymphocyte (Plaque forming cell number), increases with the age and reduces gradually.Gavage Fructus Mori water decoction 12.5g (crude drug)/kg every day to LACA mice, continuous 10 days, can dramatically the T lymphocyte increasing age groups mice; 2. every day Fructus Mori decoct 12.5g/kg is gavaged, continuous 2 weeks to BALb/c and the LACA mouse inbred lines at 3-24 monthly age to the impact of Na+-K+-ATP enzymatic activity.Except 24 monthly age aged mouses, more all can show reduction erythrocyte membrane Na+-K+-ATP enzymatic activity with age-matched control group.Nature and flavor: sweet; Acid; Cold in nature.Gui Jing: liver; Kidney channel.Function cures mainly: nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation.
Radix grewiae bilobae: base is former: be the Herb of Tiliaceae plant bilobed grewia.Nature and flavor: sweet; Bitter; Temperature.Gui Jing: liver; Spleen; Stomach warp.Function cures mainly: invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Main insufficiency of the spleen lack of appetite; Proctoptosis of a specified duration; Infantile malnutrition; Ascariasis; Rheumatic arthralgia; Seminal emission; Metrorrhagia; Leukorrhagia; Uterine prolapse.
test example 1the clinical practice of the preparation (embodiment 5) of gained treatment sciatica of the present invention:
1, data and method
1.1 physical data
That chooses that in July, 2009, in December ,-2013 carried out the treatment of my institute is diagnosed as sciatica patient totally 368 examples, wherein male patient's totally 232 examples, female patient is totally 136 examples, age is in 43-65 year, mean age adds and subtracts 3.5 years old 56.5, all patients all take the photograph the inspection such as sheet, CT scan, anti-" O " through x-ray, are diagnosed as sciatica.
1.2 diagnostic criteria
(1) pain is on rear side of buttocks thigh, and after shank, outside is radiated to sufficient lateral part;
(2) have pressure pain point along sciatic nerve areal area, La Saige (laseque) levies the positive;
(3) motion in various degree, sensation, reflection and vegetative nerve functional disturbance is had within the scope of sciatic nerve domination.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random, and all patients are at the age, and the aspect such as the state of an illness, the course of disease is through statistical procedures, and no significant difference (P > 0.05), has comparability.Wherein experimental group takes products obtained therefrom of the present invention, instructions of taking: twice daily, each 100-120mL, warmly takes, 7 days courses for the treatment of.Matched group takes other medicines (as conventional medication such as Giraldi daphne tablet, Huoluo Xiaoling Dan, sinew-soothing Network-Quickening Pills).Observe four courses for the treatment of of treatment altogether.
1.4 curative effect determinate standard
Recovery from illness: clinical symptoms disappears completely, and movable function is normal;
Effective: clinical cardinal symptom disappears, and still have after overworking and do not accommodate pain, movable function is normal;
Effective: clinical symptoms is improved before comparatively treating, pain relief;
Invalid: after treatment, clinical symptoms is without improving or increasing the weight of.
Total effective rate=(recovery from illness number of cases+effective number of cases+effectively number of cases) ∕ total inspection case load × 100%.
1.5 therapeutic outcome
The therapeutic outcome of two groups of patients, as shown in table 1:
Table 1: the therapeutic outcome of experimental group and matched group patient compares
Therapeutic effect: experimental group is fully recovered 176 examples (71.6%), effective 53 examples (21.5%); Effective 11 examples (4.5%), invalid 6 examples (2.4%), total effective rate is 97.6%.From result, experimental group therapeutic effect is obviously better than matched group.
The present invention select Fructus Aurantii, ti, Flos jasmini, Flos Rosae Davuricae, Herba Stachydis Japonicae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Chinese mugwort, Herba lysimachiae capillipedis, Radix Scrophulariae, Herba Viciae Amoenae and nine sons in thousand not from mother etc. totally 16 taste primary raw material medicines be prepared from.Fang Zhong, Fructus Aurantii has regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row; Flos jasmini soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain; Flos Rosae Davuricae regulating qi-flowing for harmonizing stomach; Herba Stachydis Japonicae heat-clearing and toxic substances removing; Chinese mugwort dispersing wind and cold in thousand, removing toxic substances and promoting subsidence of swelling; Herba lysimachiae capillipedis inducing diuresis to remove edema; Herba Viciae Amoenae wind-damp dispelling, invigorates blood circulation, relaxing muscles and tendons, pain relieving; Suona horn flower invigorating spleen to remove dampness, promoting flow of QI and blood; Radix grewiae bilobae invigorating the spleen and benefiting QI, expelling wind and removing dampness.All medicines share, and play promoting the flow of QI in the collateral by warming the meridian, expelling wind and removing dampness, promoting blood circulation and stopping pain, strengthening bone and muscle, effect of filling blood altogether.After treating four courses for the treatment of, treatment group effective percentage can reach 97.6%, and matched group is only 80.3%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the preparation of sciatica, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Aurantii 8-16; Ti 10-13; Flos jasmini 9-12; Flos Rosae Davuricae 3-6; Herba Stachydis Japonicae 8-13; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6-12; Chinese mugwort 8-14 in thousand; Herba lysimachiae capillipedis 10-15; Radix Scrophulariae 12-17; Herba Viciae Amoenae 9-15; Nine sons are not from female 7-13; Herba Medicaginis Lupulinae 6-12; Suona horn flower 8-15; RADIX ET RHIZOMA LIGULARIAE 10-14; Fructus Mori 8-12; Radix grewiae bilobae 9-14.
2. the preparation for the treatment of sciatica as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Aurantii 10-14; Ti 11-12; Flos jasmini 10-11; Flos Rosae Davuricae 4-5; Herba Stachydis Japonicae 9.5-11.5; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 8-10; Chinese mugwort 10-12 in thousand; Herba lysimachiae capillipedis 11-14; Radix Scrophulariae 13.5-15.5; Herba Viciae Amoenae 11-13; Nine sons are not from female 9-11; Herba Medicaginis Lupulinae 8-10; Suona horn flower 10-13; RADIX ET RHIZOMA LIGULARIAE 11-13; Fructus Mori 9-11; Radix grewiae bilobae 10.5-12.5.
3. the preparation for the treatment of sciatica as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Aurantii 12; Ti 11.5; Flos jasmini 10.5; Flos Rosae Davuricae 4.5; Herba Stachydis Japonicae 10.5; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 9; Chinese mugwort 11 in thousand; Herba lysimachiae capillipedis 12.5; Radix Scrophulariae 14.5; Herba Viciae Amoenae 12; Nine sons are not from female 10; Herba Medicaginis Lupulinae 9; Suona horn spends 11.5; RADIX ET RHIZOMA LIGULARIAE 12; Fructus Mori 10; Radix grewiae bilobae 11.5.
4. the preparation of the treatment sciatica as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Flos jasmini and Flos Rosae Davuricae are cleaned respectively, are together placed in parch container, and intense fire heats, stir-baked the crude drugs into black on outside and brown in inside, take out, cool, grind into powder, for subsequent use;
(2) ti shave is placed in Sucus Zingberis and soaks 12-18 minute (be preferably placed in Sucus Zingberis soak 15 minutes), and take out, be not together placed in frying pan with Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Stachydis Japonicae and nine sons from mother, moderate heat heats, and stir-frying to buff is degree, and taking-up cools, for subsequent use;
(3) Fructus Mori and Herba Viciae Amoenae are placed in Chinese medicine pan, and add the clear water slow fire boiling 15-35 minute clear water slow fire boiling of 4 times amount (preferably add 25 minutes) of 3.5-4.5 times amount, filter, filtrate is for subsequent use;
(4) crude drug and Fructus Aurantii after step (2) being processed, within thousand, end, Herba lysimachiae capillipedis, Radix Scrophulariae, Herba Medicaginis Lupulinae, suona horn are colored, RADIX ET RHIZOMA LIGULARIAE and Radix grewiae bilobae are together placed in Chinese medicine pan, add clear water and be placed in powder 3-5cm, slow fire heating decoction twice, first time decocts 22-40 minute (preferably first time decocts 30 minutes), second time decocts 10-18 minute (preferably second time decocts 14 minutes), merge twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (3) and (4) gained filtrate are merged, add the crude drug after step (1) process, continue slow fire boiling 10-20 minute (preferably continuing slow fire boiling 15 minutes), three aspect filtered through gauze, dry heat sterilization, encapsulation, to obtain final product.
5. the preparation method of the decoction for the treatment of sciatica according to claim 4, it is characterized in that, in step (3), the temperature of dry heat sterilization is 88-102 DEG C (temperature of preferred dry heat sterilization is 92-98 DEG C, and the temperature of the dry heat sterilization be more preferably is 95 DEG C).
6. the preparation method of the decoction for the treatment of sciatica according to claim 4, it is characterized in that, in step (3), the time of dry heat sterilization is 16-30 minute (time of preferred dry heat sterilization is 20-26 minute, and the time of the dry heat sterilization be more preferably is 23 minutes).
7. the preparation of the treatment sciatica as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) Fructus Aurantii removes flesh, and with Fructus Gleditsia water soaking 2-4 days of 3-4 times of raw material dose the Fructus Gleditsia water soaking of 3.5 times of raw material doses (preferably use 3 days), take out, be placed on tile with Ai Yitong in thousand, intense fire heats, and dries, cools, smash into fine powder to pieces, for subsequent use;
(2) Flos jasmini and Flos Rosae Davuricae are cleaned respectively, add the Mel (preferably adding the Mel of 0.35 times of raw material dose) of 0.25-0.45 times of raw material dose, mix thoroughly, vexed 6-10 minute (preferably vexed 8 minutes), take out, slow fire heats, and frying extremely tack-free is degree, dry, smash into fine powder to pieces, for subsequent use;
(3) Chinese medicine water extraction is not adopted to extract from female and RADIX ET RHIZOMA LIGULARIAE ti, Herba Stachydis Japonicae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Radix Scrophulariae, Fructus Mori, nine sons, with the cold water of 6-8 times of raw material dose for solvent (preferably with the cold water of 7 times of raw material doses for solvent), slow fire heating extraction twice, first time extracts 30-40 minute (preferably first time extracts 35 minutes), second time is extracted 15-25 minute (preferably second time is extracted 20 minutes), merges twice Aqueous extracts, filters, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) Herba lysimachiae capillipedis, Herba Viciae Amoenae, Herba Medicaginis Lupulinae, suona horn flower and Radix grewiae bilobae are placed in Chinese medicine dehydrator, in 45-65 DEG C of dry 38-60 minute (being preferable over 55 DEG C of dryings 50 minutes), taking out, pulverize into fine powder, for subsequent use;
(5) joined in step (3) gained thick paste by the raw material medicated powder after step (1), (2) and (4) process, add sucrose fine and cross-linked cellulose while stirring, mixing, granulate, dry, granulate, incapsulates shell, to obtain final product.
8. the preparation of the treatment sciatica as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable granule, preparation method is as follows:
(1) get thousand Chinese mugwort and Herba Viciae Amoenae be placed in Chinese medicine baking oven, in 60-80 DEG C of dry 20-30 minute (being preferable over 70 DEG C of dryings 25 minutes), taking-up, be placed in pulverizer and be ground into fine powder, for subsequent use;
(2) Fructus Aurantii, ti, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Stachydis Japonicae and Radix Scrophulariae are placed in the wheat bran made popular, continue slow fire heating, when being coke yellow to wheat bran, take out, sieve the wheat bran that defocuses, cool, for subsequent use;
(3) Flos jasmini, Flos Rosae Davuricae, Herba lysimachiae capillipedis and Herba Medicaginis Lupulinae are placed in hermetic container, the yellow wine adding 1.5-3.5 times amount is mixed thoroughly (yellow wine preferably adding 2.5 times amount is mixed thoroughly), adds a cover stewing 4-8 minute (preferably adding a cover stewing 6 minutes), takes out, for subsequent use;
(4) crude drug after step (2) and (3) process and nine sons are not together placed in frying pan from mother, suona horn flower, RADIX ET RHIZOMA LIGULARIAE, Fructus Mori and Radix grewiae bilobae, add clear water and do not have powder 3-4cm, big fire heated and boiled, turn little fire to decoct 35-55 minute (preferably turning little fire to decoct 45 minutes), filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.18-1.20, spraying dry, get dry extract powder, for subsequent use;
(5) crude drug after step (1) being processed mixes with step (4) gained dried cream powder, is placed in granulator and granulates, and dry, granulate, subpackage, to obtain final product.
9. the preparation of the treatment sciatica as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable powder, preparation method is as follows:
(1) Fructus Mori smashs into pureed to pieces, with ti, Herba Stachydis Japonicae, within thousand, to end and Radix grewiae bilobae is together placed in traditional Chinese medicine drying device, in 55-65 DEG C of dry 35-55 minute (being preferable over 60 DEG C of dryings 45 minutes), taking out, grinds as fine powder, for subsequent use;
(2) get Fructus Aurantii, Radix Scrophulariae, suona horn flower and RADIX ET RHIZOMA LIGULARIAE mixing, the saline solution adding 15%-25% is mixed thoroughly (saline solution preferably adding 20% is mixed thoroughly), and moistening is sucked to saline solution, takes out, and slow fire heating fried dry is degree, and taking-up cools, and smashs into fine powder to pieces, for subsequent use;
(3) by the crude drug except step (1) and (2), pulverizing respectively, be placed in the penetrating bag of Chinese medicine, take ethanol as solvent, reflux, extract, twice, each respectively extraction 12-20 minute (preferably each each extraction 16 minutes), merges twice alcohol extract, filtration, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20-1.23, and vacuum drying gets dry extract powder, for subsequent use;
(4) the crude drug mixing after being processed step (1)-(3), sterilizing encapsulates, and to obtain final product.
10. the preparation method of the powder for the treatment of sciatica as claimed in claim 9, it is characterized in that, in step (3), the amount of solvent is the 3.5-7.5 of raw material dose doubly (amount of preferred solvent is 4.5-6.5 times of raw material dose, and the amount of the solvent be more preferably is 5.5 times of raw material dose).
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| CN105213646A (en) * | 2015-11-19 | 2016-01-06 | 王海鹏 | For the Chinese medicine composition and preparation method thereof of injury of sciatic nerve postoperative rehabilitation |
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