CN105456856A - Pharmaceutical for treating chronic cough and preparation method thereof - Google Patents

Pharmaceutical for treating chronic cough and preparation method thereof Download PDF

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CN105456856A
CN105456856A CN201510941887.9A CN201510941887A CN105456856A CN 105456856 A CN105456856 A CN 105456856A CN 201510941887 A CN201510941887 A CN 201510941887A CN 105456856 A CN105456856 A CN 105456856A
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radix
grams
gram
rhizoma
semen
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张朝兰
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张朝兰
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Abstract

The invention discloses a pharmaceutical for treating chronic cough and a preparation method thereof. The pharmaceutical is prepared mainly from in a certain weight proportion: Cortex Mori, Flos Farfarae, Herba Houttuyniae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, Radix Ginseng, Semen Armeniacae Amarum, Herba Ephedrae, Radix Asparagi, Folium Eriobotryae, Rhizoma Dioscoreae, Exocarpium Citri Rubrum, Gypsum Fibrosum, Radix Rehmanniae Preparata, Semen Arecae, Rhizoma Bletillae, Flos Carthami, Semen Raphani, Radix et Rhizoma Rhei, Radix Scutellariae, Rhizoma Atractylodis Macrocephalae, Radix Stemonae, Pericarpium Citri Reticulatae, Herba Centipedae and Fructus Arctii. The pharmaceutical has the functions of purging lung to relieve asthma, moistening lung to remove stasis, relieving cough to reduce phlegm, regulating qi and tonifying spleen, eliminating dampness and eliminating phlegm and treating cough with excessive phlegm, and is high in acting speed and good in therapeutic effect for treating chronic cough without recurrence.

Description

A kind of medicine for the treatment of chronic cough and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of chronic cough and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Chronic cough is the protectiveness respiratory reflex action that human body removes secretions in respiratory tract or foreign body.Although there is the one side that it is favourable, violent long-term chronic cough can cause respiratory tract hemorrhage, and as a long time, frequently, violent chronic cough affects work, has a rest, even causes laryngalgia, hoarseness and breathing myalgia.The traditional Chinese medical science then thinks that chronic cough and diseases caused by exogenous pathogenic factor attack lung, phlegm dampness in lungs, liver-fire invading the lung, and lung yin loss is relevant.Because western medicine side effect is large, therefore there is great demand to the Chinese medicine of effectively treating chronic cough in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment chronic cough, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment chronic cough.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Cortex Mori, Flos Farfarae, Herba Houttuyniae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, Radix Ginseng, Semen Armeniacae Amarum, Herba Ephedrae, Radix Asparagi, Folium Eriobotryae, Rhizoma Dioscoreae, Exocarpium Citri Rubrum, Gypsum Fibrosum, Radix Rehmanniae Preparata, Radix Asteris, Semen Arecae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Carthami, Semen Plantaginis, Semen Raphani, Radix Et Rhizoma Rhei, Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae, the Radix Stemonae, Pericarpium Citri Reticulatae, Herba Centipedae, Fructus Arctii, Herba Portulacae, Rhizoma Polygonati Odorati, Semen Sinapis medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat chronic cough.Wherein, select Cortex Mori to be that cold, enter lung, spleen channel, have eliminating pathogen from the lung for relieving asthma, the function of line water detumescence, controls dyspnea and cough due to lung-heat because its nature and flavor are sweet, spit blood, edema, beriberi, dysuria.Flos Farfarae is selected to be that temperature, enters lung meridian, have nourishing the lung to keep the adverse QI downward, the function of the antitussive that reduces phlegm, control cough with dyspnea and pant, sore throat because its nature and flavor are pungent.Herba Houttuyniae is selected to be that cold, enter meridian of Hand-TAI YIN, have heat-clearing and toxic substances removing, the function of inducing diuresis to remove edema, controls pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies because its nature and flavor are pungent.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Bulbus Fritillariae Cirrhosae is selected to be because its property bitter but sweet flavor, cool, enter lung meridian, have lung moistening eliminating stagnation, the function that antitussive reduces phlegm, control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Radix Ginseng is selected to be that temperature, enters spleen, lung meridian, have strongly invigorating primordial QI because its nature and flavor are sweet micro-sweet, Gu promote the production of body fluid de-, the function of calming the nerves, controls impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Semen Armeniacae Amarum is selected to be that temperature, poisonous, enter lung, large intestine channel, have expelling phlegm for arresting cough, relieving asthma, the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation because its nature and flavor are bitter.Herba Ephedrae is selected to be that temperature, enters lung, urinary bladder channel, have diaphoresis, relieving asthma because its nature and flavor are worked hard, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache nasal obstruction, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness, cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Select Folium Eriobotryae to be because its nature and flavor are bitter, cool, attach to the lung and stomach meridians, have lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm, control lung-heat phlegmatic cough, hemoptysis, epistaxis, gastric heat is vomitted the sound of vomiting.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, have spleen invigorating, tonifying the lung, reinforce the kidney, the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Exocarpium Citri Rubrum to be that temperature, enters brothers' sun, the sun, Yangming Channel, have expectorant, promoting the circulation of QI, alleviating distention in middle-JIAO, the function of eliminating stagnation, control wind and cold phlegmatic cough because its nature and flavor are worked hard, feel sick, guttation, chest pain feeling of distension and oppression.Gypsum Fibrosum is selected to be because its property acrid-sweet flavor, cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select Radix Asteris to be because its nature and flavor are bitter, temperature, enter lung meridian, have warming the lung, the therapeutic method to keep the adverse QI flowing downwards, clearing away phlegm, the function of cough-relieving, controls wind and cold, and cough, Zhichuan, asthenia coughs vomiting bloody pus.Select Semen Arecae to be because its nature and flavor toil, temperature, enters spleen, stomach, large intestine channel, has parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, the function of row water, control malnutrition due to parasitic infestation, dyspepsia, abdominal distention, and heavy after dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium , Disorder ties.Select Pseudobulbus Bletillae (Rhizoma Bletillae) to be because its property bitter but sweet flavor, cool, enter lung meridian, have tonifying the lung, hemostasis, detumescence, raw sight, the function of sore, control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea , mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Semen Plantaginis is selected to be that cold, enter liver, spleen two warp, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, jaundice, edema, and hematodiarrhoea is had loose bowels, epistaxis, conjunctival congestion and swelling pain, sore throat tonsillitis because its nature and flavor are sweet, cough, skin ulcer.Semen Raphani is selected to be because its property acrid-sweet flavor, flat, enter lung, stomach warp, have therapeutic method to keep the adverse QI flowing downwards Dingchuan, the function eliminated indigestion and phlegm, control cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, heavy after dysentery.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi , lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.The Radix Stemonae is selected to be that tepor, enters lung meridian, has gentle lung qi, cough-relieving, and the function of parasite killing, controls cough due to wind and cold, pertussis, pulmonary tuberculosis, old cough with asthma, ascarid, enterobiasis, skin scabies, eczema because its nature and flavor sweetness and bitterness.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select Herba Centipedae to be that temperature, enters meridian of Hand-TAI YIN edema caused by disorder of QI, dispel the wind, cold expelling because its nature and flavor are pungent, victory is wet, removing nebula, the function of stuffy nose relieving plug, cure cold, asthma of cold-type, sore throat, pertussis, eruptive disease is suffered from abdominal pain, amebic dysentery, malaria, infantile malnutrition with diarrhea, nasal sinusitis, polyp, corneal nebula is puckery itches, ecthyma, scabies, traumatic injury.Select Fructus Arctii to be that cool, enter lung, stomach warp, have dispelling wind and heat pathogens, lung qi dispersing rash, the function of subduing swelling and detoxicating, controls cough due to pathogenic wind-heat, laryngopharynx swelling and pain because its nature and flavor are worked hard, macule is not saturating, and rubella is had an itch, carbuncle sore tumefacting virus.Select Herba Portulacae to be because its nature and flavor acid, cold, enter large intestine, liver, spleen channel, have heat-clearing and toxic substances removing, the function of loose blood detumescence, controls hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.Select Rhizoma Polygonati Odorati to be that flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst because its nature and flavor are sweet, control calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Semen Sinapis nature and flavor are hot, have warming spleen and stomach for dispelling cold, the function of promoting the circulation of QI eliminating phlegm, control cold syndrome of the stomach and tell food, trusted subordinate's pain, lung cold cough.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
Cortex Mori 10-20 gram, Flos Farfarae 5-15 gram, Herba Houttuyniae 5-15 gram, Radix Glycyrrhizae 15-25 gram, Bulbus Fritillariae Cirrhosae 5-15 gram, Radix Ginseng 5-15 gram, Semen Armeniacae Amarum 10-20 gram, Herba Ephedrae 7-12 gram, Radix Asparagi 10-20 gram, Folium Eriobotryae 10-15 gram, Rhizoma Dioscoreae 5-15 gram, Exocarpium Citri Rubrum 5-10 gram, Gypsum Fibrosum 7-12 gram, Radix Rehmanniae Preparata 10-15 gram, Radix Asteris 10-20 gram, Semen Arecae 5-15 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram, Flos Carthami 15-25 gram, Semen Plantaginis 10-25 gram, Semen Raphani 10-15 gram, Radix Et Rhizoma Rhei 10-20 gram, Radix Scutellariae 10-20 gram, Rhizoma Atractylodis Macrocephalae 10-15 gram, Radix Stemonae 10-15 gram, Pericarpium Citri Reticulatae 5-15 gram, Herba Centipedae 5-10 gram, Fructus Arctii 5-15 gram, Herba Portulacae 10-20 gram, Rhizoma Polygonati Odorati 10-15 gram, Semen Sinapis 5-15 gram.
Be preferably:
Cortex Mori 15 grams, Flos Farfarae 10 grams, Herba Houttuyniae 10 grams, 20 grams, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae 10 grams, Radix Ginseng 10 grams, 15 grams, Semen Armeniacae Amarum, 9 grams, Herba Ephedrae, Radix Asparagi 15 grams, Folium Eriobotryae 12 grams, Rhizoma Dioscoreae 10 grams, Exocarpium Citri Rubrum 10 grams, 9 grams, Gypsum Fibrosum, Radix Rehmanniae Preparata 12 grams, Radix Asteris 15 grams, Semen Arecae 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, 20 grams, Flos Carthami, Semen Plantaginis 15 grams, Semen Raphani 12 grams, Radix Et Rhizoma Rhei 15 grams, Radix Scutellariae 15 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, the Radix Stemonae 12 grams, Pericarpium Citri Reticulatae 10 grams, Herba Centipedae 8 grams, Fructus Arctii 10 grams, Herba Portulacae 15 grams, Rhizoma Polygonati Odorati 12 grams, 8 grams, Semen Sinapis.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;
2, Flos Farfarae: get and pick clean Flos Farfarae and add certain amount of boiling water with refined honey, mix thoroughly, slightly vexed, put in pot and fry to buff with slow fire, till tack-free, taking-up cools, every Flos Farfarae 10 jin refined honey 25 jin;
3, Herba Houttuyniae: remove impurity, removing undesirable root, cleans cutting, dries;
4, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
5, Bulbus Fritillariae Cirrhosae: pick decontamination, is soaked in water, and pulls out, and moistening peels off the heart, dries;
6, Radix Ginseng: except removing LU, cutting;
7, Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;
8, Herba Ephedrae: pick decontamination, removes most woody stems and undesirable root, washes, and cutting after micro-profit, is drying to obtain;
9, Radix Asparagi: pick decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;
10, Folium Eriobotryae: brush away fine hair, washes, and slightly moistens, and shredding is dried;
11, Rhizoma Dioscoreae: pick clean impurity, is soaked in water to Rhizoma Dioscoreae central part is softening, pulls out and slightly dry in the air, and section is dried or dried;
12, Exocarpium Citri Rubrum: pick decontamination, outwash, used time folding is broken;
13, Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;
14, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
15, Radix Asteris: pick decontamination, removes residual stem, and clean, slightly moistening, is cut into segment, dries;
16, Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;
17, Pseudobulbus Bletillae (Rhizoma Bletillae): pick decontamination, is soaked in water, and pulls out, dries in the air to humidity and is suitable for, cut into slices, dry;
18, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
19, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
20, Semen Raphani: decontamination of winnowing with a dustpan, rinses earth, pulls out, dries, and the used time smashs to pieces;
21, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, moistening is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
22, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;
23, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
24, the Radix Stemonae: pick clean impurity, removing fibrous root, cleans, runs through rear cutting, dry;
25, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
26, Herba Centipedae: pick clean impurity, cutting, dry;
27, Fructus Arctii: pick decontamination, sieve removes spare;
28, Herba Portulacae: pick clean impurity, removing undesirable root, slightly moisten with water, cutting is dried;
29, Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
30, Semen Sinapis: get former medicine and to winnow with a dustpan clean impurity, puts in pot and fries to buff, micro-savory time take out, cool;
Two, prepare
1, the Cortex Mori after the process of preparing Chinese medicine, Flos Farfarae, Herba Houttuyniae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, Radix Ginseng, Semen Armeniacae Amarum, Herba Ephedrae, Radix Asparagi, Folium Eriobotryae, Rhizoma Dioscoreae, Exocarpium Citri Rubrum, Gypsum Fibrosum, Radix Rehmanniae Preparata, Radix Asteris, Semen Arecae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Carthami, Semen Plantaginis, Semen Raphani, Radix Et Rhizoma Rhei, Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae, the Radix Stemonae, Pericarpium Citri Reticulatae, Herba Centipedae, Fructus Arctii, Herba Portulacae, Rhizoma Polygonati Odorati, Semen Sinapis are put into decocting container, add water 8 times amount for the first time, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, the medicinal residues of filtration are added 6 times amount, intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, by twice decoction liquor mixing and stirring and get final product, 4 doses are divided into take.
In prescription, Cortex Mori has eliminating pathogen from the lung for relieving asthma, controls dyspnea and cough due to lung-heat, and the function of haematemesis is monarch drug; Bulbus Fritillariae Cirrhosae lung moistening eliminating stagnation, antitussive reduces phlegm; Radix Asteris has warming the lung, the therapeutic method to keep the adverse QI flowing downwards, water expectorant, the function of cough-relieving, the two is ministerial drug, and three taste medicines play eliminating pathogen from the lung for relieving asthma jointly, lung moistening eliminating stagnation, antitussive reduces phlegm, warming the lung, the therapeutic method to keep the adverse QI flowing downwards, water expectorant, the effect of cough-relieving, treatment chronic cough effect is comprehensive, and with eliminating pathogen from the lung for relieving asthma, lung moistening eliminating stagnation, it is that master can be effected a permanent cure that antitussive reduces phlegm, Radix Glycyrrhizae has and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription, the function of separating poison of drug and alimentary toxicosis is adjuvant drug, and Pericarpium Citri Reticulatae has regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, the function controlling cough with copious phlegm, for making medicine, is take stopgap measures with all medicines of remainder.
Medicine of the present invention has eliminating pathogen from the lung for relieving asthma, lung moistening eliminating stagnation, and antitussive reduces phlegm, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, controls the function of cough with copious phlegm, is used for the treatment of chronic cough, short treating period, instant effect, non-relapse after healing.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Taking medicinal liquid super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept chronic cough out-patient totally 37 examples for medical treatment.
2, diagnostic criteria
Classical symptom is for being long-term refractory dry cough, and usually bring out after suction penetrating odor, cold air, contact allergen, motion or upper respiratory tract infection, some patients is without any inducement.How to aggravate at night or morning.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 7 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: chronic cough transference cure, body constitution recovers normal, recovery from illness;
Take a turn for the better: patient's cough with asthma, abundant expectoration phenomenon alleviates, and chronic cough symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy Chronic Cough Patients 37 example of the present invention, effective 31 examples of result, obvious effective rate is 83.78%, and take a turn for the better 5 examples, and improvement rate is 13.51%, and invalid 1 example, total effective rate is 97.29%.

Claims (3)

1. treat a medicine for chronic cough, it is characterized in that: it is made up of the crude drug in following weight range:
Cortex Mori 10-20 gram, Flos Farfarae 5-15 gram, Herba Houttuyniae 5-15 gram, Radix Glycyrrhizae 15-25 gram, Bulbus Fritillariae Cirrhosae 5-15 gram, Radix Ginseng 5-15 gram, Semen Armeniacae Amarum 10-20 gram, Herba Ephedrae 7-12 gram, Radix Asparagi 10-20 gram, Folium Eriobotryae 10-15 gram, Rhizoma Dioscoreae 5-15 gram, Exocarpium Citri Rubrum 5-15 gram, Gypsum Fibrosum 7-12 gram, Radix Rehmanniae Preparata 10-15 gram, Radix Asteris 10-20 gram, Semen Arecae 5-15 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram, Flos Carthami 15-25 gram, Semen Plantaginis 10-15 gram, Semen Raphani 10-15 gram, Radix Et Rhizoma Rhei 10-20 gram, Radix Scutellariae 10-20 gram, Rhizoma Atractylodis Macrocephalae 10-15 gram, Radix Stemonae 10-15 gram, Pericarpium Citri Reticulatae 5-15 gram, Herba Centipedae 5-10 gram, Fructus Arctii 5-15 gram, Herba Portulacae 10-20 gram, Rhizoma Polygonati Odorati 10-15 gram, Semen Sinapis 5-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Cortex Mori 15 grams, Flos Farfarae 10 grams, Herba Houttuyniae 10 grams, 20 grams, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae 10 grams, Radix Ginseng 10 grams, 15 grams, Semen Armeniacae Amarum, 9 grams, Herba Ephedrae, Radix Asparagi 15 grams, Folium Eriobotryae 12 grams, Rhizoma Dioscoreae 10 grams, Exocarpium Citri Rubrum 10 grams, 9 grams, Gypsum Fibrosum, Radix Rehmanniae Preparata 12 grams, Radix Asteris 15 grams, Semen Arecae 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, 20 grams, Flos Carthami, Semen Plantaginis 15 grams, Semen Raphani 12 grams, Radix Et Rhizoma Rhei 15 grams, Radix Scutellariae 15 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, the Radix Stemonae 12 grams, Pericarpium Citri Reticulatae 10 grams, Herba Centipedae 8 grams, Fructus Arctii 10 grams, Herba Portulacae 15 grams, Rhizoma Polygonati Odorati 12 grams, 8 grams, Semen Sinapis.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;
(2) Flos Farfarae: get and pick clean Flos Farfarae and add certain amount of boiling water with refined honey, mix thoroughly, slightly vexed, put in pot and fry to buff with slow fire, till tack-free, taking-up cools, every Flos Farfarae 10 jin refined honey 25 jin;
(3) Herba Houttuyniae: remove impurity, removing undesirable root, cleans cutting, dries;
(4) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(5) Bulbus Fritillariae Cirrhosae: pick decontamination, is soaked in water, and pulls out, and moistening peels off the heart, dries;
(6) Radix Ginseng: except removing LU, cutting;
(7) Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;
(8) Herba Ephedrae: pick decontamination, removes most woody stems and undesirable root, washes, and cutting after micro-profit, is drying to obtain;
(9) Radix Asparagi: pick decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;
(10) Folium Eriobotryae: brush away fine hair, washes, and slightly moistens, and shredding is dried;
(11) Rhizoma Dioscoreae: pick clean impurity, is soaked in water to Rhizoma Dioscoreae central part is softening, pulls out and slightly dry in the air, and section is dried or dried;
(12) Exocarpium Citri Rubrum: pick decontamination, outwash, used time folding is broken;
(13) Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;
(14) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
(15) Radix Asteris: pick decontamination, removes residual stem, and clean, slightly moistening, is cut into segment, dries;
(16) Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;
(17) Pseudobulbus Bletillae (Rhizoma Bletillae): pick decontamination, is soaked in water, and pulls out, dries in the air to humidity and is suitable for, cut into slices, dry;
(18) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
(19) Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
(20) Semen Raphani: decontamination of winnowing with a dustpan, rinses earth, pulls out, dries, and the used time smashs to pieces;
(21) Radix Et Rhizoma Rhei: pick clean impurity, size stepping, moistening is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
(22) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;
(23) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(24) Radix Stemonae: pick clean impurity, removing fibrous root, cleans, runs through rear cutting, dry;
(25) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
(26) Herba Centipedae: pick clean impurity, cutting, dry;
(27) Fructus Arctii: pick decontamination, sieve removes spare;
(28) Herba Portulacae: pick clean impurity, removing undesirable root, slightly moisten with water, cutting is dried;
(29) Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
(30) Semen Sinapis: get former medicine and to winnow with a dustpan clean impurity, puts in pot and fries to buff, micro-savory time take out, cool;
(2) prepare
(1) Cortex Mori after the process of preparing Chinese medicine, Flos Farfarae, Herba Houttuyniae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, Radix Ginseng, Semen Armeniacae Amarum, Herba Ephedrae, Radix Asparagi, Folium Eriobotryae, Rhizoma Dioscoreae, Exocarpium Citri Rubrum, Gypsum Fibrosum, Radix Rehmanniae Preparata, Radix Asteris, Semen Arecae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Carthami, Semen Plantaginis, Semen Raphani, Radix Et Rhizoma Rhei, Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae, the Radix Stemonae, Pericarpium Citri Reticulatae, Herba Centipedae, Fructus Arctii, Herba Portulacae, Rhizoma Polygonati Odorati, Semen Sinapis are put into decocting container, add water 8 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;
(2) add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;
(3) by twice decoction liquor mixing and stirring and get final product, 4 doses are divided into take.
CN201510941887.9A 2015-12-16 2015-12-16 Pharmaceutical for treating chronic cough and preparation method thereof Pending CN105456856A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075374A (en) * 2016-08-19 2016-11-09 毛德西 Cough relief traditional Chinese medicine for treating winter disease in summer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
欧阳荣等: "《常用非处方药物速查手册》", 30 April 2015, 湖南科学技术出版社 *
肖国士等: "《中医秘方全书(珍藏本)超值版》", 30 June 2012, 湖南科学技术出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075374A (en) * 2016-08-19 2016-11-09 毛德西 Cough relief traditional Chinese medicine for treating winter disease in summer

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Application publication date: 20160406