CN105106817A - Yao medicine compound broadleaf globethistle inflorescence tablet for treating diabetes and preparation method thereof - Google Patents
Yao medicine compound broadleaf globethistle inflorescence tablet for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Yao medicine compound broadleaf globethistle inflorescence tablet for treating diabetes and a preparation method thereof. The tablet is prepared from 20-30 parts of broadleaf globethistle inflorescence, 10-20 parts of glutinous rice dumpling leaves or roots, 20-30 parts of paederia scandens, 20-30 parts of tomentose fevervine herb, 8-18 parts of herba polygoni avicularis, 5-15 parts of radix cudramiae, 3-13 parts of affine cudweed, 2-12 parts of garden balsam stem, 10-20 parts of puerarin, 5-15 parts of tortoise plastron, 4-15 parts of turtle shell, 2-14 parts of semen cuscutae, 1-10 parts of epimedium, 13-28 parts of yam, 12-24 parts of scrophulariae, 4-16 parts of amomum, 7-19 parts of ramulus euonyrni and 6-18 parts of mulberry. Backflow extraction is conducted on broadleaf globethistle inflorescence, glutinous rice dumpling leaves or roots, paederia scandens and tomentose fevervine herb through a traditional Chinese medicine extraction agent, and then extracts are compatible with other traditional Chinese medicine for use; the preparation method is simple, devices are easy to operate, the extraction rate of active pharmaceutical ingredients and the utilization rate of energy can be increased, and popularization value is achieved.
Description
Technical field
The present invention relates to Chinese medicinal tablet field, be specifically related to a kind of precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes and preparation method thereof.
Background technology
Diabetes are one of modal chronic diseases, claim four of current threat human health large Chronic Non-Communicable Diseasess with hypertension, coronary heart disease and tumor.Along with the raising of people's living standard, the increase of aged tendency of population and fat incidence rate, the sickness rate of diabetes is in the trend risen year by year.Diabetes mainly act on body by inherited genetic factors, immunologic function disorder and food drink multiple virulence factor such as daily life is not normal and cause body hypoinsulinism and insulin resistant, thus a series of metabolism disorder syndrome such as sugar, protein, fat, water and eletrolytes caused, its harm almost involves that whole body is any organizes internal organs, infection, heart change, cerebrovascular disease, renal failure can be caused, lose the sight of both eyes, lower limb are gangrenous, thus become the lethal main cause disabled.In addition, the hypoglycemic coma that diabetic hyperosmolar ketoacidosis and glucose-lowering treatment cause is the serious acute complication of diabetes.The treatment of diabetes is still unsatisfactory, the medicine of the treatment diabetes that exploitation is efficient, low toxicity, curative effect are lasting and solve diabetes patient throughout one's life the problem of taking medicine be the vital task for the treatment of diabetes.
At present, treat diabetes and be mostly edible Western medicine, as medicines such as sulfonylurea drugs, biguanides, alpha-glucosidase inhibitor, Thiazolidinediones, blood sugar regulator used during user having meals and insulins, these medicines all thoroughly can not cure diabetes, and having toxic and side effects in various degree, long-term taking meeting grievous injury liver, kidney, affect gastrointestinal function, its complication is difficult to control especially, and all has " knock-on " phenomenon in various degree after drug withdrawal.Therefore, need a kind of Chinese medicinal tablet for the treatment of diabetes badly, taking convenience, pharmaceutically active is large, determined curative effect, treating both the principal and secondary aspects of a disease.
The content of invention
An object of the present invention is to solve at least the problems referred to above and/or defect, and the advantage will illustrated at least is below provided.
A further object of the invention is to provide one and treats diabetes precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet, it is by Flos Echinopsis latifolii and Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate compatibility, there is synergy, evident in efficacy, effective, function carbohydrate metabolism can be recovered rapidly, reduce blood fat, promote insulin secretion, keep glucostasis.
A further object of the invention is to provide a kind of preparation method for the treatment of diabetes precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet, by Flos Echinopsis latifolii and Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate Chinese traditional medicine's extractant reflux, extract, use with other drug matchings again, preparation method of the present invention is simple, equipment is easy to operate, the extraction ratio of active constituents of medicine and the utilization rate of the energy can be improved, there is promotional value.
In order to realize these objects of the present invention and other advantage, provide a kind of precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 20 ~ 30 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 10 ~ 20 parts, fevervine 20 ~ 30 parts, hair leaf xanthate 20 ~ 30 parts, Herba Ecliptae 8 ~ 18 parts, Radix Cudraniae 5 ~ 15 parts, Herba Gnaphalii Affinis 3 ~ 13 parts, Herba speranskiae tuberculatae 2 ~ 12 parts, Radix Puerariae 10 ~ 20 parts, Carapax et Plastrum Testudinis 5 ~ 15 parts, Carapax Trionycis 4 ~ 15 parts, Semen Cuscutae 2 ~ 14 parts, Herba Epimedii 1 ~ 10 part, Rhizoma Dioscoreae 13 ~ 28 parts, Radix Scrophulariae 12 ~ 24 parts, Fructus Amomi 4 ~ 16 parts, Ramulus Euonymi 7 ~ 19 parts and Fructus Mori 6 ~ 18 parts.
Preferably, the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of described treatment diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 23 ~ 27 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 3 ~ 17 parts, fevervine 23 ~ 27 parts, hair leaf xanthate 23 ~ 27 parts, Herba Ecliptae 11 ~ 15 parts, Radix Cudraniae 8 ~ 12 parts, Herba Gnaphalii Affinis 6 ~ 10 parts, Herba speranskiae tuberculatae 5 ~ 9 parts, Radix Puerariae 13 ~ 17 parts, Carapax et Plastrum Testudinis 8 ~ 12 parts, Carapax Trionycis 7 ~ 12 parts, Semen Cuscutae 5 ~ 11 parts, Herba Epimedii 4 ~ 7 parts, Rhizoma Dioscoreae 10 ~ 25 parts, Radix Scrophulariae 15 ~ 21 parts, Fructus Amomi 7 ~ 13 parts, Ramulus Euonymi 10 ~ 16 parts and Fructus Mori 9 ~ 15 parts.
Preferably, the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of described treatment diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 25 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 10 parts, fevervine 25 part, mao leaf xanthate 25 parts, Herba Ecliptae 13 parts, Radix Cudraniae 10 parts, Herba Gnaphalii Affinis 8 parts, Herba speranskiae tuberculatae 7 parts, Radix Puerariae 15 parts, Carapax et Plastrum Testudinis 10 parts, Carapax Trionycis 10 parts, Semen Cuscutae 8 parts, Herba Epimedii 6 parts, Rhizoma Dioscoreae 13 parts, Radix Scrophulariae 18 parts, Fructus Amomi 10 parts, Ramulus Euonymi 13 parts and Fructus Mori 11 parts.
The preparation method that a further object of the invention can also chase after wind tablet by a kind of precious jade recurrence due to taking drug side for the treatment of diabetes further realizes, and comprises the following steps:
Step a, the Radix Puerariae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori to be pulverized respectively, mixing is placed in the clear water of 2 ~ 4 times amount soaks 2 ~ 4h, filter, be separated to obtain the first filtering residue and the first filtrate, by described first filtering residue by 2: 2: 6 mass ratio be divided into three parts, be numbered mixture A, mixture B and mixture C, in described first filtrate, add the alcoholic solution that ethanol is mixed with 70 ~ 80%, obtain extractant;
Step b, the Flos Echinopsis latifolii of above-mentioned parts by weight, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae to be mixed with the mixture C obtained in step a, be placed in multifunctional extracting pot, the ethanol of 1 ~ 3 times amount is added in described multifunctional extracting pot, heating evaporate to dryness ethanol, then the extractant obtained in the step a of 5 ~ 7 times amount is added, reflux, extract, 1 ~ 3 time, merge extractive liquid, collect the extraction slag in multifunctional extracting pot, obtain the second filtering residue;
Step c, the second filtering residue obtained in step b to be mixed with described mixture A, be placed in the leakage cylinder of washing tank, and the mass concentration adding 1 ~ 2 times amount is the alcoholic solution of 40 ~ 50%, stirs 20 ~ 30min, then described leakage cylinder is upwards promoted, described leakage cylinder is not contacted with alcoholic solution, extrude the washed-residue on described leakage cylinder, repeated washing 1 ~ 3 time, merge cleaning mixture, collect described washed-residue, obtain the 3rd filtering residue;
Steps d, get the extracting solution non-woven fabrics that obtains in step b and filter twice, then hydrochloric acid adjust pH 5.5 ~ 6.0 is added, after leaving standstill 1 ~ 3h, use microporous filter membrane filtration, hydro-oxidation sodium adjust pH 7.5 ~ 8.0 in filtrate, then after leaving standstill 1 ~ 3h, use microporous filter membrane filtration, collect the extracting solution after filtering and mix with the cleaning mixture obtained in step c, being placed in Three-effect concentration device and concentrating, obtain the extractum that relative density is 1.07 ~ 1.12;
Step e, the extractum obtained in steps d and described mixture B and described 3rd filtering residue are mixed to get mixed material, put into the jade articles of 60 DEG C, described mixed material is taken out after the temperature of described jade articles is down to room temperature, described jade articles is heated to 60 DEG C, again put into described mixed material and be naturally down to room temperature, then take out oven dry, pelletize, obtain label through tabletting machine;
The water that step f, the gelatin taking 60 ~ 80 weight portions add 30 ~ 40 weight portions makes it expand, the Oleum Camelliae of the glycerol and 10 ~ 15 weight portions that then add 15 ~ 20 weight portions is mixed and heated to 60 ~ 80 DEG C, after being uniformly mixed, being incubated 1 ~ 2h at 60 DEG C, then filtering to obtain coating materials;
The coating materials that step g, the label obtained by step e, the acceptable adjuvant of pharmacy and step f obtain is placed in flaker obtained precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet.
Preferably, the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of described treatment diabetes, the tank body of described washing tank is cylindrical-shaped structure, and described tank interior is provided with first body of rod, two second bodies of rod, circular plate body and described leakage cylinders from top to bottom successively:
Described first body of rod is the loop bar that can stretch up and down, described loop bar is formed by the hollow connecting rod of at least two joints successively fit, the top bearing of the upper end and described tank body that are positioned at the described connecting rod of the top is connected, and the outer wall being positioned at the described connecting rod of bottom is provided with groove vertically;
The first end of described two second bodies of rod is all flexibly connected with a slide block, and described slide block can slide up and down in described groove, and the second end of described two second bodies of rod is hinged with the upper surface of described circular plate body respectively;
Described circular plate body comprises two semicircle plate bodys, described two semicircle plate bodys are all hinged with the lower end of the described connecting rod being positioned at bottom, make the angle of the upper surface of described two semicircle plate bodys can become 0 ~ 240 °, when the upper surface of described two semicircle plate bodys forms 180 ° of angles, form the plane of level;
Described leakage cylinder is cylindrical-shaped structure, and it can slide up and down with described inner tank wall and be connected, and described leakage cylinder is 1: 1.1 ~ 1.2 with the diameter ratio of described tank body, and described leakage cylinder and described tank body aspect ratio are 1: 2 ~ 3.
Preferably, the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of described treatment diabetes, the radius of described semicircle plate body and the radius ratio of described leakage cylinder are 0.9: 1.
Preferably, the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of described treatment diabetes, the bottom of described washing tank is provided with screen pack, and the top of described washing tank is provided with dog-house, and bottom is provided with liquid outlet.
Preferably, the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of described treatment diabetes, the acceptable adjuvant of described pharmacy is one or more in Semen Maydis powder, calcium silicates, sodium carboxymethyl cellulose, myristyl alcohol, fish glue, Talcum.
The present invention at least comprises following beneficial effect:
The first, the present invention adopts Flos Echinopsis latifolii to have good blood circulation promoting and blood stasis dispelling and the effect of benefiting QI and nourishing blood, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root have the effects such as clearing away heat and promoting production of body fluid, cooling blood for hemostasis, diuresis, fevervine has expelling wind and removing dampness, analgesic antidotal, the effects such as promoting digestion and removing stagnation, the blood fat reducing of hair leaf xanthate energy, promote islet secretion, four Chinese medicine material and Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae compatibility use, and can recover function carbohydrate metabolism rapidly, thrombus, dredging and vessel softening, adjustment blood glucose, keep glucostasis;
The second, the present invention also arranges in pairs or groups the Chinese medicine of Radix Puerariae, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori, and Radix Puerariae: sweet in the mouth is pungent, expelling pathogenic factors from muscles for reducing heat; Carapax et Plastrum Testudinis: property is put down, sweet in the mouth, nourishing YIN for suppressing the hyperactive YANG, and kidney tonifying builds bone; Carapax Trionycis: taste becomes, property is put down, clearing away heat and alleviating pain; Semen Cuscutae: warm in nature, sweet in the mouth, nourishing the liver and kidney; Herba Epimedii: sweet, flat, blood pressure lowering, blood fat reducing, arrhythmia, increases cerebral blood flow; Rhizoma Dioscoreae: sweet, flat, spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission; Radix Scrophulariae: bitter in the mouth, is slightly cold, coronary artery dilator, YIN nourishing, pathogenic fire reducing; Fructus Amomi, warm in nature, acrid in the mouth, during circulation of qi promoting is adjusted, stomach function regulating is amusing; Ramulus Euonymi, bitter in the mouth, cold in nature, promoting the circulation of blood is stimulated the menstrual flow, eliminating stasis to stop pain; Fructus Mori, sweet in the mouth acid, cold in nature, the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, kind nourishing YIN and benefiting blood; Collocation uses evident in efficacy, and cost is low;
Three, Radix Puerariae, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori clear water soak and tentatively extract Effective Component of Chinese Medicine by the present invention, proportional different three parts are divided by the filtering residue after soaking, mix at the Traditional Chinese drug mixture of different phase and Flos Echinopsis latifolii, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae, the effective ingredient of two class medicinal material mixture is merged largely mutually;
Four, with the liquid dosage alcoholic solution soaking Chinese medicine, for the reflux, extract, effective ingredient of Flos Echinopsis latifolii, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae, originally the extracting solution containing Effective Component of Chinese Medicine promotes the stripping of active substance in Flos Echinopsis latifolii, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae, and is conducive to the mutual fusion of every Chinese medicine;
Five, also mass efficient material is contained in remaining Chinese medicine slag after reflux, extract, extraction slag is mixed with mixture A and is placed in washing tank, add alcoholic solution, abundant stirring, extruding is separated, reclaim cleaning mixture, improve the collection rate of Chinese medicine active ingredient, make the extraction ratio of the active constituents of medicine of Chinese medicine and utilization rate reach maximization;
Six, extracting solution is first filtered twice removing medicinal residues bits by nonwoven gauze by the present invention, by regulating the Acidity of Aikalinity of extracting solution, microporous filter membrane filtration is used respectively under solutions of weak acidity and weak basic condition, the content of highly acid in extracting solution and strong alkaline substance can be reduced, thus reduce the zest of extracting solution, unwanted impurity can be removed simultaneously, reach the effect of purification;
Seven, the present invention design washing tank in first body of rod be that loop bar can shrink up and down, operation and storage when not using time easy to use, second body of rod drives two semicircle plate bodys to rotate under the movement of slide block, thus the angle of the upper surface of two semicircle plate bodys can be regulated, when slide block moves to extreme higher position, the angle of the upper surface of two semicircle plate bodys is 0 °, realizes the function of convenient for collecting; When slide block moves down in a groove, the angle of the upper surface of two semicircle plate bodys increases gradually, when increasing to 180 °, two semicircular plate bodies form the plane of a level, and now first body of rod moves down, leakage cylinder moves up, the alcoholic solution of two semicircle plate bodys to bottom has downward pressure, cleaning mixture discharge rate is accelerated, increases work efficiency, the washed-residue on Lous cylinder can be extruded, the collection rate of raising cleaning mixture simultaneously; When slide block moves to extreme lower position, the angle of the upper surface of two semicircle plate bodys is maximum 240 °, first body of rod moves to applicable position, two semicircle plate bodys can stir the medicinal residues leaked in cylinder and alcoholic solution under the rotation of first body of rod, function diversification, save space, automaticity is high, can by slag and the effective ingredient mixed in A extract largely in advance;
Eight, jade articles can launch middle infrared (Mid-IR) under thermal condition, the jade articles of 60 DEG C is put into after extractum, mixture B and the 3rd filtering residue being mixed, ingredient in extractum, mixture B and the 3rd filtering residue produces molecular resonance in middle infrared (Mid-IR), the fusion of active substance can be promoted, repeat jade articles intensification Temperature fall, ensure Effective Component of Chinese Medicine non-inactivation;
Nine, Chinese medicine extract label outer wrap of the present invention gelatine glaze agent and the acceptable adjuvant of pharmacy, make flap-type, be convenient to clothes for patients use, have certain slow releasing function to medicine, can not hinder again stripping and the absorption of medicine.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Accompanying drawing explanation
Fig. 1 is the structural representation of washing tank described in the present invention;
The structural representation that Fig. 2 is connected with described first body of rod and described two second bodies of rod for circular slab described in the present invention.
Detailed description of the invention:
Below in conjunction with embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
< embodiment 1>
Treat a precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 20 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 10 parts, fevervine 20 part, mao leaf xanthate 20 parts, Herba Ecliptae 8 parts, Radix Cudraniae 5 parts, Herba Gnaphalii Affinis 3 parts, Herba speranskiae tuberculatae 2 parts, Radix Puerariae 10 parts, Carapax et Plastrum Testudinis 5 parts, Carapax Trionycis 4 parts, Semen Cuscutae 2 parts, Herba Epimedii 1 part, Rhizoma Dioscoreae 13 parts, Radix Scrophulariae 12 parts, Fructus Amomi 4 parts, Ramulus Euonymi 7 parts and Fructus Mori 6 parts.
Treat a preparation method for the compound recipe Flos Echinopsis latifolii tablet of the precious jade medicine of diabetes, comprise the following steps:
Step a, the Radix Puerariae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori to be pulverized respectively, mixing is placed in the clear water of 2 times amount soaks 2h, filter, be separated to obtain the first filtering residue and the first filtrate, by described first filtering residue by 2: 2: 6 mass ratio be divided into three parts, be numbered mixture A, mixture B and mixture C, in described first filtrate, add the alcoholic solution that ethanol is mixed with 70%, obtain extractant;
Step b, the Flos Echinopsis latifolii of above-mentioned parts by weight, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae to be mixed with the mixture C obtained in step a, be placed in multifunctional extracting pot, the ethanol of 1 times amount is added in described multifunctional extracting pot, heating evaporate to dryness ethanol, then the extractant obtained in the step a of 5 times amount is added, reflux, extract, 1 time, merge extractive liquid, collect the extraction slag in multifunctional extracting pot, obtain the second filtering residue;
Step c, the second filtering residue obtained in step b to be mixed with described mixture A, be placed in the leakage cylinder 7 of washing tank, and the mass concentration adding 1 times amount is the alcoholic solution of 40%, stirs 20min, then described leakage cylinder 7 is upwards promoted, described leakage cylinder 7 is not contacted with alcoholic solution, extrude the washed-residue on described leakage cylinder 7, repeated washing 1 time, merge cleaning mixture, collect described washed-residue, obtain the 3rd filtering residue;
Wherein, the tank body of described washing tank is cylindrical-shaped structure, and described tank interior is provided with first body of rod, 4, two second bodies of rod 6, circular plate body 5 and described leakage cylinder 7 from top to bottom successively:
Described first body of rod 4 is the loop bar that can stretch up and down, described loop bar is formed by the hollow connecting rod of at least two joints successively fit, operation and storage when not using time easy to use, the top bearing of the upper end and described tank body that are positioned at the described connecting rod of the top is connected, and the outer wall being positioned at the described connecting rod of bottom is provided with groove 3 vertically;
The first end of described two second bodies of rod 6 is all flexibly connected with a slide block 8, described slide block 8 can slide up and down in described groove 3, second end of described two second bodies of rod 6 is hinged with the upper surface of described circular plate body 5 respectively, second body of rod 6 drives two semicircle plate bodys to rotate under the movement of slide block 8, thus can regulate the angle of the upper surface of two semicircle plate bodys;
Described circular plate body 5 comprises two semicircle plate bodys, described two semicircle plate bodys are all hinged with the lower end of the described connecting rod being positioned at bottom, make the angle of the upper surface of described two semicircle plate bodys can become 0 ~ 240 °, when the upper surface of described two semicircle plate bodys forms 180 ° of angles, the plane of formation level is convenient to extrude the washed-residue leaked on cylinder 7;
Described leakage cylinder 7 is cylindrical-shaped structure, it can slide up and down with described inner tank wall and be connected, described leakage cylinder 7 is 1: 1.1 ~ 1.2 with the diameter ratio of described tank body, and described leakage cylinder 7 is 1: 2 ~ 3 with described tank body aspect ratio, and the radius of described semicircle plate body and the radius ratio of described leakage cylinder 7 are 0.9: 1;
The bottom of described washing tank is provided with screen pack, and the top of described washing tank is provided with dog-house 1, and bottom is provided with liquid outlet 2.
Steps d, get the extracting solution non-woven fabrics obtained in step b to filter twice, removing medicinal residues bits, then hydrochloric acid adjust pH 5.5 is added, after leaving standstill 1h, use microporous filter membrane filtration, hydro-oxidation sodium adjust pH 7.5 in filtrate, after leaving standstill 1h again, use microporous filter membrane filtration, by regulating the Acidity of Aikalinity of extracting solution, microporous filter membrane filtration is used respectively under solutions of weak acidity and weak basic condition, the content of highly acid in extracting solution and strong alkaline substance can be reduced, thus reduce the zest of extracting solution, unwanted impurity can be removed simultaneously, reach the effect of purification, collect the extracting solution after filtering and mix with the cleaning mixture obtained in step c, be placed in Three-effect concentration device to concentrate, obtain the extractum that relative density is 1.07,
Step e, the extractum obtained in steps d and described mixture B and described 3rd filtering residue are mixed to get mixed material, put into the jade articles of 60 DEG C, described mixed material is taken out after the temperature of described jade articles is down to room temperature, described jade articles is heated to 60 DEG C, again put into described mixed material and be naturally down to room temperature, then oven dry is taken out, pelletize, label is obtained through tabletting machine, extractum, ingredient in mixture B and the 3rd filtering residue produces molecular resonance in middle infrared (Mid-IR), the fusion of active substance can be promoted, repeat jade articles intensification Temperature fall, ensure Effective Component of Chinese Medicine non-inactivation,
The water that step f, the gelatin taking 60 weight portions add 30 weight portions makes it expand, and the Oleum Camelliae of the glycerol and 10 weight portions that then add 15 weight portions is mixed and heated to 60 DEG C, after being uniformly mixed, and is incubated 1h, then filters to obtain coating materials at 60 DEG C;
The coating materials that step g, the label obtained by step e, Semen Maydis powder, calcium silicates, myristyl alcohol, Talcum and step f obtain is placed in flaker obtained precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet, be convenient to clothes for patients use, there is certain slow releasing function to medicine, stripping and the absorption of medicine can not be hindered again.
< embodiment 2>
Treat a precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 23 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 3 parts, fevervine 23 part, mao leaf xanthate 23 parts, Herba Ecliptae 11 parts, Radix Cudraniae 8 parts, Herba Gnaphalii Affinis 6 parts, Herba speranskiae tuberculatae 5 parts, Radix Puerariae 13 parts, Carapax et Plastrum Testudinis 8 parts, Carapax Trionycis 7 parts, Semen Cuscutae 5 parts, Herba Epimedii 4 parts, Rhizoma Dioscoreae 10 parts, Radix Scrophulariae 15 parts, Fructus Amomi 7 parts, Ramulus Euonymi 10 parts and Fructus Mori 9 parts.
Treat a preparation method for the compound recipe Flos Echinopsis latifolii tablet of the precious jade medicine of diabetes, comprise the following steps:
Step a, the Radix Puerariae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori to be pulverized respectively, mixing is placed in the clear water of 2 times amount soaks 2h, filter, be separated to obtain the first filtering residue and the first filtrate, by described first filtering residue by 2: 2: 6 mass ratio be divided into three parts, be numbered mixture A, mixture B and mixture C, in described first filtrate, add the alcoholic solution that ethanol is mixed with 70%, obtain extractant;
Step b, the Flos Echinopsis latifolii of above-mentioned parts by weight, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae to be mixed with the mixture C obtained in step a, be placed in multifunctional extracting pot, the ethanol of 1 times amount is added in described multifunctional extracting pot, heating evaporate to dryness ethanol, then add the extractant obtained in the step a of 5 times amount, reflux, extract, 1 time, merge and obtain extracting solution, collect the extraction slag in multifunctional extracting pot, obtain the second filtering residue;
Step c, the second filtering residue obtained in step b to be mixed with described mixture A, be placed in the leakage cylinder 7 of washing tank, and the mass concentration adding 1 times amount is the alcoholic solution of 40%, stirs 20min, then described leakage cylinder 7 is upwards promoted, described leakage cylinder 7 is not contacted with alcoholic solution, extrude the washed-residue on described leakage cylinder 7, repeated washing 1 time, merge cleaning mixture, collect described washed-residue, obtain the 3rd filtering residue;
Wherein, the tank body of described washing tank is cylindrical-shaped structure, and described tank interior is provided with first body of rod, 4, two second bodies of rod 6, circular plate body 5 and described leakage cylinder 7 from top to bottom successively:
Described first body of rod 4 is the loop bar that can stretch up and down, described loop bar is formed by the hollow connecting rod of at least two joints successively fit, operation and storage when not using time easy to use, the top bearing of the upper end and described tank body that are positioned at the described connecting rod of the top is connected, and the outer wall being positioned at the described connecting rod of bottom is provided with groove 3 vertically;
The first end of described two second bodies of rod 6 is all flexibly connected with a slide block 8, described slide block 8 can slide up and down in described groove 3, second end of described two second bodies of rod 6 is hinged with the upper surface of described circular plate body 5 respectively, second body of rod 6 drives two semicircle plate bodys to rotate under the movement of slide block 8, thus can regulate the angle of the upper surface of two semicircle plate bodys;
Described circular plate body 5 comprises two semicircle plate bodys, described two semicircle plate bodys are all hinged with the lower end of the described connecting rod being positioned at bottom, make the angle of the upper surface of described two semicircle plate bodys can become 0 ~ 240 °, when the upper surface of described two semicircle plate bodys forms 180 ° of angles, the plane of formation level is convenient to extrude the washed-residue leaked on cylinder 7;
Described leakage cylinder 7 is cylindrical-shaped structure, it can slide up and down with described inner tank wall and be connected, described leakage cylinder 7 is 1: 1.1 with the diameter ratio of described tank body, and described leakage cylinder 7 is 1: 2 with described tank body aspect ratio, and the radius of described semicircle plate body and the radius ratio of described leakage cylinder 7 are 0.9: 1;
The bottom of described washing tank is provided with screen pack, and the top of described washing tank is provided with dog-house 1, and bottom is provided with liquid outlet 2.
Steps d, get the extracting solution non-woven fabrics obtained in step b to filter twice, removing medicinal residues bits, then hydrochloric acid adjust pH 5.5 is added, after leaving standstill 1h, use microporous filter membrane filtration, hydro-oxidation sodium adjust pH 7.5 in filtrate, after leaving standstill 1h again, use microporous filter membrane filtration, by regulating the Acidity of Aikalinity of extracting solution, microporous filter membrane filtration is used respectively under solutions of weak acidity and weak basic condition, the content of highly acid in extracting solution and strong alkaline substance can be reduced, thus reduce the zest of extracting solution, unwanted impurity can be removed simultaneously, reach the effect of purification, collect the extracting solution after filtering and mix with the cleaning mixture obtained in step c, be placed in Three-effect concentration device to concentrate, obtain the extractum that relative density is 1.07,
Step e, the extractum obtained in steps d and described mixture B and described 3rd filtering residue are mixed to get mixed material, put into the jade articles of 60 DEG C, described mixed material is taken out after the temperature of described jade articles is down to room temperature, described jade articles is heated to 60 DEG C, again put into described mixed material and be naturally down to room temperature, then oven dry is taken out, pelletize, label is obtained through tabletting machine, extractum, ingredient in mixture B and the 3rd filtering residue produces molecular resonance in middle infrared (Mid-IR), the fusion of active substance can be promoted, repeat jade articles intensification Temperature fall, ensure Effective Component of Chinese Medicine non-inactivation,
The water that step f, the gelatin taking 60 weight portions add 30 weight portions makes it expand, and the Oleum Camelliae of the glycerol and 10 weight portions that then add 15 weight portions is mixed and heated to 60 DEG C, after being uniformly mixed, and is incubated 1h, then filters to obtain coating materials at 60 DEG C;
The coating materials that step g, the label obtained by step e, Semen Maydis powder, sodium carboxymethyl cellulose, myristyl alcohol, Talcum and step f obtain is placed in flaker obtained precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet, be convenient to clothes for patients use, there is certain slow releasing function to medicine, stripping and the absorption of medicine can not be hindered again.
< embodiment 3>
Treat a precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 27 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 17 parts, fevervine 27 part, mao leaf xanthate 27 parts, Herba Ecliptae 15 parts, Radix Cudraniae 12 parts, Herba Gnaphalii Affinis 10 parts, Herba speranskiae tuberculatae 9 parts, Radix Puerariae 17 parts, Carapax et Plastrum Testudinis 12 parts, Carapax Trionycis 12 parts, Semen Cuscutae 11 parts, Herba Epimedii 7 parts, Rhizoma Dioscoreae 25 parts, Radix Scrophulariae 21 parts, Fructus Amomi 13 parts, Ramulus Euonymi 16 parts and Fructus Mori 15 parts.
Treat a preparation method for the compound recipe Flos Echinopsis latifolii tablet of the precious jade medicine of diabetes, comprise the following steps:
Step a, the Radix Puerariae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori to be pulverized respectively, mixing is placed in the clear water of 4 times amount soaks 4h, filter, be separated to obtain the first filtering residue and the first filtrate, by described first filtering residue by 2: 2: 6 mass ratio be divided into three parts, be numbered mixture A, mixture B and mixture C, in described first filtrate, add the alcoholic solution that ethanol is mixed with 80%, obtain extractant;
Step b, the Flos Echinopsis latifolii of above-mentioned parts by weight, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae to be mixed with the mixture C obtained in step a, be placed in multifunctional extracting pot, the ethanol of 3 times amount is added in described multifunctional extracting pot, heating evaporate to dryness ethanol, then add the extractant obtained in the step a of 7 times amount, reflux, extract, 3 times, merge and obtain extracting solution, collect the extraction slag in multifunctional extracting pot, obtain the second filtering residue;
Step c, the second filtering residue obtained in step b to be mixed with described mixture A, be placed in the leakage cylinder 7 of washing tank, and the mass concentration adding 2 times amount is the alcoholic solution of 50%, stirs 30min, then described leakage cylinder 7 is upwards promoted, described leakage cylinder 7 is not contacted with alcoholic solution, extrude the washed-residue on described leakage cylinder 7, repeated washing 3 times, merge cleaning mixture, collect described washed-residue, obtain the 3rd filtering residue;
Wherein, the tank body of described washing tank is cylindrical-shaped structure, and described tank interior is provided with first body of rod, 4, two second bodies of rod 6, circular plate body 5 and described leakage cylinder 7 from top to bottom successively:
Described first body of rod 4 is the loop bar that can stretch up and down, described loop bar is formed by the hollow connecting rod of at least two joints successively fit, operation and storage when not using time easy to use, the top bearing of the upper end and described tank body that are positioned at the described connecting rod of the top is connected, and the outer wall being positioned at the described connecting rod of bottom is provided with groove 3 vertically;
The first end of described two second bodies of rod 6 is all flexibly connected with a slide block 8, described slide block 8 can slide up and down in described groove 3, second end of described two second bodies of rod 6 is hinged with the upper surface of described circular plate body 5 respectively, second body of rod 6 drives two semicircle plate bodys to rotate under the movement of slide block 8, thus can regulate the angle of the upper surface of two semicircle plate bodys;
Described circular plate body 5 comprises two semicircle plate bodys, described two semicircle plate bodys are all hinged with the lower end of the described connecting rod being positioned at bottom, make the angle of the upper surface of described two semicircle plate bodys can become 0 ~ 240 °, when the upper surface of described two semicircle plate bodys forms 180 ° of angles, the plane of formation level is convenient to extrude the washed-residue leaked on cylinder 7;
Described leakage cylinder 7 is cylindrical-shaped structure, it can slide up and down with described inner tank wall and be connected, described leakage cylinder 7 is 1: 1.2 with the diameter ratio of described tank body, and described leakage cylinder 7 is 1: 3 with described tank body aspect ratio, and the radius of described semicircle plate body and the radius ratio of described leakage cylinder 7 are 0.9: 1;
The bottom of described washing tank is provided with screen pack, and the top of described washing tank is provided with dog-house 1, and bottom is provided with liquid outlet 2.
Steps d, get the extracting solution non-woven fabrics obtained in step b to filter twice, removing medicinal residues bits, then hydrochloric acid adjust pH 6.0 is added, after leaving standstill 3h, use microporous filter membrane filtration, hydro-oxidation sodium adjust pH 8.0 in filtrate, after leaving standstill 3h again, use microporous filter membrane filtration, by regulating the Acidity of Aikalinity of extracting solution, microporous filter membrane filtration is used respectively under solutions of weak acidity and weak basic condition, the content of highly acid in extracting solution and strong alkaline substance can be reduced, thus reduce the zest of extracting solution, unwanted impurity can be removed simultaneously, reach the effect of purification, collect the extracting solution after filtering and mix with the cleaning mixture obtained in step c, be placed in Three-effect concentration device to concentrate, obtain the extractum that relative density is 1.12,
Step e, the extractum obtained in steps d and described mixture B and described 3rd filtering residue are mixed to get mixed material, put into the jade articles of 60 DEG C, described mixed material is taken out after the temperature of described jade articles is down to room temperature, described jade articles is heated to 60 DEG C, again put into described mixed material and be naturally down to room temperature, then oven dry is taken out, pelletize, label is obtained through tabletting machine, extractum, ingredient in mixture B and the 3rd filtering residue produces molecular resonance in middle infrared (Mid-IR), the fusion of active substance can be promoted, repeat jade articles intensification Temperature fall, ensure Effective Component of Chinese Medicine non-inactivation,
The water that step f, the gelatin taking 80 weight portions add 40 weight portions makes it expand, and the Oleum Camelliae of the glycerol and 15 weight portions that then add 20 weight portions is mixed and heated to 80 DEG C, after being uniformly mixed, and is incubated 2h, then filters to obtain coating materials at 60 DEG C;
The coating materials that step g, the label obtained by step e, Semen Maydis powder, calcium silicates, fish glue, Talcum and step f obtain is placed in flaker obtained precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet, be convenient to clothes for patients use, there is certain slow releasing function to medicine, stripping and the absorption of medicine can not be hindered again.
< embodiment 4>
Treat a precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 30 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 20 parts, fevervine 30 part, mao leaf xanthate 30 parts, Herba Ecliptae 18 parts, Radix Cudraniae 15 parts, Herba Gnaphalii Affinis 13 parts, Herba speranskiae tuberculatae 12 parts, Radix Puerariae 20 parts, Carapax et Plastrum Testudinis 15 parts, Carapax Trionycis 15 parts, Semen Cuscutae 14 parts, Herba Epimedii 10 parts, Rhizoma Dioscoreae 28 parts, Radix Scrophulariae 24 parts, Fructus Amomi 16 parts, Ramulus Euonymi 19 parts and Fructus Mori 18 parts.
Treat a preparation method for the compound recipe Flos Echinopsis latifolii tablet of the precious jade medicine of diabetes, comprise the following steps:
Step a, the Radix Puerariae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori to be pulverized respectively, mixing is placed in the clear water of 4 times amount soaks 4h, filter, be separated to obtain the first filtering residue and the first filtrate, by described first filtering residue by 2: 2: 6 mass ratio be divided into three parts, be numbered mixture A, mixture B and mixture C, in described first filtrate, add the alcoholic solution that ethanol is mixed with 80%, obtain extractant;
Step b, the Flos Echinopsis latifolii of above-mentioned parts by weight, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae to be mixed with the mixture C obtained in step a, be placed in multifunctional extracting pot, the ethanol of 3 times amount is added in described multifunctional extracting pot, heating evaporate to dryness ethanol, then add the extractant obtained in the step a of 7 times amount, reflux, extract, 3 times, merge and obtain extracting solution, collect the extraction slag in multifunctional extracting pot, obtain the second filtering residue;
Step c, the second filtering residue obtained in step b to be mixed with described mixture A, be placed in the leakage cylinder 7 of washing tank, and the mass concentration adding 2 times amount is the alcoholic solution of 50%, stirs 30min, then described leakage cylinder 7 is upwards promoted, described leakage cylinder 7 is not contacted with alcoholic solution, extrude the washed-residue on described leakage cylinder 7, repeated washing 3 times, merge cleaning mixture, collect described washed-residue, obtain the 3rd filtering residue;
Wherein, the tank body of described washing tank is cylindrical-shaped structure, and described tank interior is provided with first body of rod, 4, two second bodies of rod 6, circular plate body 5 and described leakage cylinder 7 from top to bottom successively:
Described first body of rod 4 is the loop bar that can stretch up and down, described loop bar is formed by the hollow connecting rod of at least two joints successively fit, operation and storage when not using time easy to use, the top bearing of the upper end and described tank body that are positioned at the described connecting rod of the top is connected, and the outer wall being positioned at the described connecting rod of bottom is provided with groove 3 vertically;
The first end of described two second bodies of rod 6 is all flexibly connected with a slide block 8, described slide block 8 can slide up and down in described groove 3, second end of described two second bodies of rod 6 is hinged with the upper surface of described circular plate body 5 respectively, second body of rod 6 drives two semicircle plate bodys to rotate under the movement of slide block 8, thus can regulate the angle of the upper surface of two semicircle plate bodys;
Described circular plate body 5 comprises two semicircle plate bodys, described two semicircle plate bodys are all hinged with the lower end of the described connecting rod being positioned at bottom, make the angle of the upper surface of described two semicircle plate bodys can become 0 ~ 240 °, when the upper surface of described two semicircle plate bodys forms 180 ° of angles, the plane of formation level is convenient to extrude the washed-residue leaked on cylinder 7;
Described leakage cylinder 7 is cylindrical-shaped structure, it can slide up and down with described inner tank wall and be connected, described leakage cylinder 7 is 1: 1.2 with the diameter ratio of described tank body, and described leakage cylinder 7 is 1: 3 with described tank body aspect ratio, and the radius of described semicircle plate body and the radius ratio of described leakage cylinder 7 are 0.9: 1;
The bottom of described washing tank is provided with screen pack, and the top of described washing tank is provided with dog-house 1, and bottom is provided with liquid outlet 2.
Steps d, get the extracting solution non-woven fabrics obtained in step b to filter twice, removing medicinal residues bits, then hydrochloric acid adjust pH 6.0 is added, after leaving standstill 3h, use microporous filter membrane filtration, hydro-oxidation sodium adjust pH 8.0 in filtrate, after leaving standstill 3h again, use microporous filter membrane filtration, by regulating the Acidity of Aikalinity of extracting solution, microporous filter membrane filtration is used respectively under solutions of weak acidity and weak basic condition, the content of highly acid in extracting solution and strong alkaline substance can be reduced, thus reduce the zest of extracting solution, unwanted impurity can be removed simultaneously, reach the effect of purification, collect the extracting solution after filtering and mix with the cleaning mixture obtained in step c, be placed in Three-effect concentration device to concentrate, obtain the extractum that relative density is 1.12,
Step e, the extractum obtained in steps d and described mixture B and described 3rd filtering residue are mixed to get mixed material, put into the jade articles of 60 DEG C, described mixed material is taken out after the temperature of described jade articles is down to room temperature, described jade articles is heated to 60 DEG C, again put into described mixed material and be naturally down to room temperature, then oven dry is taken out, pelletize, label is obtained through tabletting machine, extractum, ingredient in mixture B and the 3rd filtering residue produces molecular resonance in middle infrared (Mid-IR), the fusion of active substance can be promoted, repeat jade articles intensification Temperature fall, ensure Effective Component of Chinese Medicine non-inactivation,
The water that step f, the gelatin taking 80 weight portions add 40 weight portions makes it expand, and the Oleum Camelliae of the glycerol and 15 weight portions that then add 20 weight portions is mixed and heated to 80 DEG C, after being uniformly mixed, and is incubated 2h, then filters to obtain coating materials at 60 DEG C;
The coating materials that step g, the label obtained by step e, Semen Maydis powder, calcium silicates, sodium carboxymethyl cellulose, Talcum and step f obtain is placed in flaker obtained precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet, be convenient to clothes for patients use, there is certain slow releasing function to medicine, stripping and the absorption of medicine can not be hindered again.
< embodiment 5>
Treat a precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for diabetes, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 25 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 10 parts, fevervine 25 part, mao leaf xanthate 25 parts, Herba Ecliptae 13 parts, Radix Cudraniae 10 parts, Herba Gnaphalii Affinis 8 parts, Herba speranskiae tuberculatae 7 parts, Radix Puerariae 15 parts, Carapax et Plastrum Testudinis 10 parts, Carapax Trionycis 10 parts, Semen Cuscutae 8 parts, Herba Epimedii 6 parts, Rhizoma Dioscoreae 13 parts, Radix Scrophulariae 18 parts, Fructus Amomi 10 parts, Ramulus Euonymi 13 parts and Fructus Mori 11 parts.
Treat a preparation method for the compound recipe Flos Echinopsis latifolii tablet of the precious jade medicine of diabetes, comprise the following steps:
Step a, the Radix Puerariae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori to be pulverized respectively, mixing is placed in the clear water of 3 times amount soaks 3h, filter, be separated to obtain the first filtering residue and the first filtrate, by described first filtering residue by 2: 2: 6 mass ratio be divided into three parts, be numbered mixture A, mixture B and mixture C, in described first filtrate, add the alcoholic solution that ethanol is mixed with 75%, obtain extractant;
Step b, the Flos Echinopsis latifolii of above-mentioned parts by weight, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae to be mixed with the mixture C obtained in step a, be placed in multifunctional extracting pot, the ethanol of 2 times amount is added in described multifunctional extracting pot, heating evaporate to dryness ethanol, then add the extractant obtained in the step a of 6 times amount, reflux, extract, 2 times, merge and obtain extracting solution, collect the extraction slag in multifunctional extracting pot, obtain the second filtering residue;
Step c, the second filtering residue obtained in step b to be mixed with described mixture A, be placed in the leakage cylinder 7 of washing tank, and the mass concentration adding 1.5 times amount is the alcoholic solution of 45%, stirs 25min, then described leakage cylinder 7 is upwards promoted, described leakage cylinder 7 is not contacted with alcoholic solution, extrude the washed-residue on described leakage cylinder 7, repeated washing 2 times, merge cleaning mixture, collect described washed-residue, obtain the 3rd filtering residue;
Wherein, the tank body of described washing tank is cylindrical-shaped structure, and described tank interior is provided with first body of rod, 4, two second bodies of rod 6, circular plate body 5 and described leakage cylinder 7 from top to bottom successively:
Described first body of rod 4 is the loop bar that can stretch up and down, described loop bar is formed by the hollow connecting rod of at least two joints successively fit, operation and storage when not using time easy to use, the top bearing of the upper end and described tank body that are positioned at the described connecting rod of the top is connected, and the outer wall being positioned at the described connecting rod of bottom is provided with groove 3 vertically;
The first end of described two second bodies of rod 6 is all flexibly connected with a slide block 8, described slide block 8 can slide up and down in described groove 3, second end of described two second bodies of rod 6 is hinged with the upper surface of described circular plate body 5 respectively, second body of rod 6 drives two semicircle plate bodys to rotate under the movement of slide block 8, thus can regulate the angle of the upper surface of two semicircle plate bodys;
Described circular plate body 5 comprises two semicircle plate bodys, described two semicircle plate bodys are all hinged with the lower end of the described connecting rod being positioned at bottom, make the angle of the upper surface of described two semicircle plate bodys can become 0 ~ 240 °, when the upper surface of described two semicircle plate bodys forms 180 ° of angles, the plane of formation level is convenient to extrude the washed-residue leaked on cylinder 7;
Described leakage cylinder 7 is cylindrical-shaped structure, it can slide up and down with described inner tank wall and be connected, described leakage cylinder 7 is 1: 1.1 with the diameter ratio of described tank body, and described leakage cylinder 7 is 1: 2.5 with described tank body aspect ratio, and the radius of described semicircle plate body and the radius ratio of described leakage cylinder 7 are 0.9: 1;
The bottom of described washing tank is provided with screen pack, and the top of described washing tank is provided with dog-house 1, and bottom is provided with liquid outlet 2.
Steps d, get the extracting solution non-woven fabrics obtained in step b to filter twice, removing medicinal residues bits, then hydrochloric acid adjust pH 5.7 is added, after leaving standstill 2h, use microporous filter membrane filtration, hydro-oxidation sodium adjust pH 7.8 in filtrate, after leaving standstill 2h again, use microporous filter membrane filtration, by regulating the Acidity of Aikalinity of extracting solution, microporous filter membrane filtration is used respectively under solutions of weak acidity and weak basic condition, the content of highly acid in extracting solution and strong alkaline substance can be reduced, thus reduce the zest of extracting solution, unwanted impurity can be removed simultaneously, reach the effect of purification, collect the extracting solution after filtering and mix with the cleaning mixture obtained in step c, be placed in Three-effect concentration device to concentrate, obtain the extractum that relative density is 1.10,
Step e, the extractum obtained in steps d and described mixture B and described 3rd filtering residue are mixed to get mixed material, put into the jade articles of 60 DEG C, described mixed material is taken out after the temperature of described jade articles is down to room temperature, described jade articles is heated to 60 DEG C, again put into described mixed material and be naturally down to room temperature, then oven dry is taken out, pelletize, label is obtained through tabletting machine, extractum, ingredient in mixture B and the 3rd filtering residue produces molecular resonance in middle infrared (Mid-IR), the fusion of active substance can be promoted, repeat jade articles intensification Temperature fall, ensure Effective Component of Chinese Medicine non-inactivation,
The water that step f, the gelatin taking 70 weight portions add 35 weight portions makes it expand, and the Oleum Camelliae of the glycerol and 13 weight portions that then add 18 weight portions is mixed and heated to 70 DEG C, after being uniformly mixed, and is incubated 1.5h, then filters to obtain coating materials at 60 DEG C;
The coating materials that step g, the label obtained by step e, Semen Maydis powder, sodium carboxymethyl cellulose, fish glue, Talcum and step f obtain is placed in flaker obtained precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet, be convenient to clothes for patients use, there is certain slow releasing function to medicine, stripping and the absorption of medicine can not be hindered again.
< test example 1>
Animal toxicity test is reported:
By after the Chinese medicinal tablet thin up that obtains in the embodiment of the present invention 5, as test medicinal liquid;
Get the mice 30 of male and female half and half, every rabbit Mouse Weight is 18 ~ 22g, after fasting 12h, by gavage in above-mentioned medicinal liquid one day 0.5ml/10g/ time, every day, secondary, serve on 7 days, observe administration reaction every day, result shows that in 30 mices 7 days, diet is normal, and none is dead and poisoning, proves that medicine is without bad toxic and side effects.
< comparative example 1>
Treatment of diabetes mellitus patients test report:
One, clinical observation:
1, see " new Chinese medicine treatment diabetes guideline of clinical investigations ", accept diabetes for medical treatment and merge peripheral nerve, vascular lesion patient 300 people, fasting glucose is all more than 9.1 mM/ls, take the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of the treatment diabetes that embodiment 5 is obtained in the present invention, divide and sooner or later take for twice, the course for the treatment of is the shortest 1 month, and the longest is 2 years.
Two, efficacy assessment standard:
This efficacy assessment standard is formulated with reference to " new Chinese medicine guideline of clinical investigations ", and specific standards is as follows:
(1) fully recover: Clinical symptom and sign disappears, blood fat, blood pressure keep normal, need not keep on a diet, can as normal person diet, do not recur in 1 year;
(2) effective: Clinical symptom and sign disappears, blood fat, blood pressure keep normal, and blood glucose is drunk after the meal close to normal range value on an empty stomach, and weight maintenance is in ideal range, and half a year is interior without recurrence;
(3) effective: Clinical symptom and sign disappears, and blood fat, blood pressure are tending towards normal gradually, islet function recovers, without recurrence in March;
(4) invalid: Clinical symptom and sign and auxiliary examination are showed no improvement.
Three, therapeutic outcome:
Table 1: therapeutic outcome
As seen from the above table, cure rate is up to 60%, and total effective rate is up to 99%, evident in efficacy; Illustrate that the tablet that the preparation method of Chinese medicinal composition preparation of the present invention obtains has good curative effect to treatment diabetes.
< comparative example 2>
Case 1, king so-and-so, man, 51 years old, fasting blood sugar 17.3mmol/L.Give the Chinese medicinal tablet that the present embodiment 5 obtains treatment, after 4 months, fasting blood sugar is down to 5.4mmol/L, and after 3 years, fasting blood sugar is down to 4.3mmol/L, triennial hypoglycemic medicine and the insulin not taking any other so far.
Case 2, poplar, man, 48 years old, diabetic history 5 years, fasting blood sugar 14.4mmol/L, through giving the Chinese medicinal tablet treatment that the present embodiment 5 obtains, fasting blood sugar was down to 5.6mmol/L after two months, working of having fully recovered, and follows up a case by regular visits to normal after 1 year.
Case 3, Wang, 30 years old, diabetic history 3 years, fasting blood sugar 14.6mmol/L, the large hemoptysis of complication pulmonary tuberculosis, hospital diagnosis was diabetes and complication, fasting blood sugar 15.1mmol/L.Give the Chinese medicinal tablet that the present embodiment 5 obtains and add the treatment of Western medicine treating pulmonery tuberculosis connection medicine, after three months, pulmonary tuberculosis is cured, and without Western medicine, singly gives the Chinese medicinal tablet treatment that the present embodiment 5 obtains, after half a year, fasting blood sugar is down to 5.1mmol/L, and continual cure is patient's recovery from illness after one month.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the embodiment described.
Claims (8)
1. treat the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet of diabetes for one kind, it is characterized in that, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 20 ~ 30 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 10 ~ 20 parts, fevervine 20 ~ 30 parts, hair leaf xanthate 20 ~ 30 parts, Herba Ecliptae 8 ~ 18 parts, Radix Cudraniae 5 ~ 15 parts, Herba Gnaphalii Affinis 3 ~ 13 parts, Herba speranskiae tuberculatae 2 ~ 12 parts, Radix Puerariae 10 ~ 20 parts, Carapax et Plastrum Testudinis 5 ~ 15 parts, Carapax Trionycis 4 ~ 15 parts, Semen Cuscutae 2 ~ 14 parts, Herba Epimedii 1 ~ 10 part, Rhizoma Dioscoreae 13 ~ 28 parts, Radix Scrophulariae 12 ~ 24 parts, Fructus Amomi 4 ~ 16 parts, Ramulus Euonymi 7 ~ 19 parts and Fructus Mori 6 ~ 18 parts.
2. the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes as claimed in claim 1, it is characterized in that, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 23 ~ 27 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 3 ~ 17 parts, fevervine 23 ~ 27 parts, hair leaf xanthate 23 ~ 27 parts, Herba Ecliptae 11 ~ 15 parts, Radix Cudraniae 8 ~ 12 parts, Herba Gnaphalii Affinis 6 ~ 10 parts, Herba speranskiae tuberculatae 5 ~ 9 parts, Radix Puerariae 13 ~ 17 parts, Carapax et Plastrum Testudinis 8 ~ 12 parts, Carapax Trionycis 7 ~ 12 parts, Semen Cuscutae 5 ~ 11 parts, Herba Epimedii 4 ~ 7 parts, Rhizoma Dioscoreae 10 ~ 25 parts, Radix Scrophulariae 15 ~ 21 parts, Fructus Amomi 7 ~ 13 parts, Ramulus Euonymi 10 ~ 16 parts and Fructus Mori 9 ~ 15 parts.
3. the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes as claimed in claim 2, it is characterized in that, described precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet comprises the Chinese medicine of following weight portion: Flos Echinopsis latifolii 25 parts, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root 10 parts, fevervine 25 part, mao leaf xanthate 25 parts, Herba Ecliptae 13 parts, Radix Cudraniae 10 parts, Herba Gnaphalii Affinis 8 parts, Herba speranskiae tuberculatae 7 parts, Radix Puerariae 15 parts, Carapax et Plastrum Testudinis 10 parts, Carapax Trionycis 10 parts, Semen Cuscutae 8 parts, Herba Epimedii 6 parts, Rhizoma Dioscoreae 13 parts, Radix Scrophulariae 18 parts, Fructus Amomi 10 parts, Ramulus Euonymi 13 parts and Fructus Mori 11 parts.
4. the precious jade recurrence due to taking drug side as the treatment diabetes as described in arbitrary in claims 1 to 3 chases after a preparation method for wind tablet, it is characterized in that, comprises the following steps:
Step a, the Radix Puerariae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Carapax Trionycis, Semen Cuscutae, Herba Epimedii, Rhizoma Dioscoreae, Radix Scrophulariae, Fructus Amomi, Ramulus Euonymi and Fructus Mori to be pulverized respectively, mixing is placed in the clear water of 2 ~ 4 times amount soaks 2 ~ 4h, filter, be separated to obtain the first filtering residue and the first filtrate, by described first filtering residue by 2: 2: 6 mass ratio be divided into three parts, be numbered mixture A, mixture B and mixture C, in described first filtrate, add the alcoholic solution that ethanol is mixed with 70 ~ 80%, obtain extractant;
Step b, the Flos Echinopsis latifolii of above-mentioned parts by weight, Asparagus zongbayi K. Y. Lang et Z. Y. Zhu or root, fevervine, hair leaf xanthate, Herba Ecliptae, Radix Cudraniae, Herba Gnaphalii Affinis and Herba speranskiae tuberculatae to be mixed with the mixture C obtained in step a, be placed in multifunctional extracting pot, the ethanol of 1 ~ 3 times amount is added in described multifunctional extracting pot, heating evaporate to dryness ethanol, then the extractant obtained in the step a of 5 ~ 7 times amount is added, reflux, extract, 1 ~ 3 time, merge extractive liquid, collect the extraction slag in multifunctional extracting pot, obtain the second filtering residue;
Step c, the second filtering residue obtained in step b to be mixed with described mixture A, be placed in the leakage cylinder of washing tank, and the mass concentration adding 1 ~ 2 times amount is the alcoholic solution of 40 ~ 50%, stirs 20 ~ 30min, then described leakage cylinder is upwards promoted, described leakage cylinder is not contacted with alcoholic solution, extrude the washed-residue on described leakage cylinder, repeated washing 1 ~ 3 time, merge cleaning mixture, collect described washed-residue, obtain the 3rd filtering residue;
Steps d, get the extracting solution non-woven fabrics that obtains in step b and filter twice, then hydrochloric acid adjust pH 5.5 ~ 6.0 is added, after leaving standstill 1 ~ 3h, use microporous filter membrane filtration, hydro-oxidation sodium adjust pH 7.5 ~ 8.0 in filtrate, then after leaving standstill 1 ~ 3h, use microporous filter membrane filtration, collect the extracting solution after filtering and mix with the cleaning mixture obtained in step c, being placed in Three-effect concentration device and concentrating, obtain the extractum that relative density is 1.07 ~ 1.12;
Step e, the extractum obtained in steps d and described mixture B and described 3rd filtering residue are mixed to get mixed material, put into the jade articles of 60 DEG C, described mixed material is taken out after the temperature of described jade articles is down to room temperature, described jade articles is heated to 60 DEG C, again put into described mixed material and be naturally down to room temperature, then take out oven dry, pelletize, obtain label through tabletting machine;
The water that step f, the gelatin taking 60 ~ 80 weight portions add 30 ~ 40 weight portions makes it expand, the Oleum Camelliae of the glycerol and 10 ~ 15 weight portions that then add 15 ~ 20 weight portions is mixed and heated to 60 ~ 80 DEG C, after being uniformly mixed, being incubated 1 ~ 2h at 60 DEG C, then filtering to obtain coating materials;
The coating materials that step g, the label obtained by step e, the acceptable adjuvant of pharmacy and step f obtain is placed in flaker obtained precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet.
5. the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes as claimed in claim 4, it is characterized in that, the tank body of described washing tank is cylindrical-shaped structure, and described tank interior is provided with first body of rod, two second bodies of rod, circular plate body and described leakage cylinders from top to bottom successively:
Described first body of rod is the loop bar that can stretch up and down, described loop bar is formed by the hollow connecting rod of at least two joints successively fit, the top bearing of the upper end and described tank body that are positioned at the described connecting rod of the top is connected, and the outer wall being positioned at the described connecting rod of bottom is provided with groove vertically;
The first end of described two second bodies of rod is all flexibly connected with a slide block, and described slide block can slide up and down in described groove, and the second end of described two second bodies of rod is hinged with the upper surface of described circular plate body respectively;
Described circular plate body comprises two semicircle plate bodys, described two semicircle plate bodys are all hinged with the lower end of the described connecting rod being positioned at bottom, make the angle of the upper surface of described two semicircle plate bodys can become 0 ~ 240 °, when the upper surface of described two semicircle plate bodys forms 180 ° of angles, form the plane of level;
Described leakage cylinder is cylindrical-shaped structure, and it can slide up and down with described inner tank wall and be connected, and described leakage cylinder is 1: 1.1 ~ 1.2 with the diameter ratio of described tank body, and described leakage cylinder and described tank body aspect ratio are 1: 2 ~ 3.
6. the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes as claimed in claim 5, it is characterized in that, the radius of described semicircle plate body and the radius ratio of described leakage cylinder are 0.9: 1.
7. the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes as claimed in claim 5, it is characterized in that, the bottom of described washing tank is provided with screen pack, and the top of described washing tank is provided with dog-house, and bottom is provided with liquid outlet.
8. the preparation method of the precious jade recurrence due to taking drug side Flos Echinopsis latifolii tablet for the treatment of diabetes as claimed in claim 4, it is characterized in that, the acceptable adjuvant of described pharmacy is one or more in Semen Maydis powder, calcium silicates, sodium carboxymethyl cellulose, myristyl alcohol, fish glue, Talcum.
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| CN106038926A (en) * | 2016-08-16 | 2016-10-26 | 汪培杰 | Traditional Chinese medicine for treating diabetes and preparation method thereof |
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Application publication date: 20151202 Assignee: GUANGXI HENGDERUN BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Assignor: GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS Contract record no.: X2023980045685 Denomination of invention: Yao medicine compound Zhugoufeng tablet for diabetes and its preparation method Granted publication date: 20181102 License type: Common License Record date: 20231106 |
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