CN105106817B - Treat the precious jade medicine compound broadleaf globethistle inflorescence tablet and preparation method thereof of diabetes - Google Patents
Treat the precious jade medicine compound broadleaf globethistle inflorescence tablet and preparation method thereof of diabetes Download PDFInfo
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Abstract
Diabetes precious jade medicine compound broadleaf globethistle inflorescence tablet and preparation method thereof, including 6~18 parts of 10~20 parts of 20~30 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 20~30 20~30 parts of part, mao leaf xanthate of fevervine, 8~18 parts of Herba Ecliptae, 5~15 parts of cudrania root, 3~13 parts of affine cudweed, 2~12 parts of lopseed, 10~20 parts of pueraria lobata, 5~15 parts of tortoiseshell, 4~15 parts of turtle shell, 2~14 parts of Semen Cuscutae, 1~10 part of Herba Epimedii, 13~28 parts of Chinese yam, 12~24 parts of radix scrophulariae, 4~16 parts of fructus amomi, 7~19 parts of Ramulus euonymi and mulberries are treated the invention discloses a kind of.The present invention is by broadleaf globethistle inflorescence and rice-pudding cake leaf or root, fevervine, hair leaf xanthate Chinese traditional medicine's extractant refluxing extraction, it is used again with other drug matchings, preparation method of the invention is simple, equipment is easy to operate, can improve the recovery rate of active constituents of medicine and the utilization rate of the energy, has promotional value.
Description
Technical field
The present invention relates to Chinese medicinal tablet fields, and in particular to a kind of precious jade medicine compound broadleaf globethistle inflorescence tablet that treating diabetes and its
Preparation method.
Background technology
Diabetes are one of most common chronic diseases, and hypertension, coronary heart disease and tumour and claim current threat human health
Four big Chronic Non-Communicable Diseases.As the improvement of people's living standards, aging of population and the increase of fat incidence,
The incidence of diabetes is in the trend risen year by year.Diabetes are mainly drunk by inherent cause, immunologic function disorder and food
Occupying a variety of virulence factor such as not normal and acting on body leads to body hypoinsulinism and insulin resistance, to what is caused
A series of metabolic disorder syndromes such as sugar, protein, fat, water and electrolyte, it is dirty that any tissue of whole body is almost involved in harm
Device can lead to infection, heart disease, cerebrovascular disease, renal failure, lose the sight of both eyes, lower limb gangrene etc., thus as lethal
The main reason for disabling.In addition, the hypoglycemic coma that diabetic hyperosmolar ketoacidosis and glucose-lowering treatment cause is diabetes
Serious acute complication.The treatment of diabetes is still unsatisfactory, efficient, less toxic, the lasting treatment diabetes of curative effect the medicine of exploitation
Object and solve the problems, such as diabetes patient take medicine throughout one's life be treat diabetes vital task.
Currently, treatment diabetes are mostly edible Western medicine, as sulfonylurea drugs, biguanides, alpha-glucosidase inhibit
The drugs such as agent, Thiazolidinediones, blood sugar regulator used during user having meals and insulin, these drugs cannot thoroughly cure glycosuria
Disease, and have different degrees of toxic side effect, liver, kidney can seriously be damaged by taking for a long time, influence gastrointestinal function, complication is more
It is to be difficult to prevent, and have different degrees of " knock-on " phenomenon after being discontinued.Therefore, there is an urgent need for a kind of Chinese medicine tablets for treating diabetes
Agent, convenient to take, pharmaceutical activity is big, curative for effect, treating both manifestation and root cause of disease.
The content of invention
It is excellent it is an object of the invention to solve at least the above and/or defect, and provide at least to will be described later
Point.
Treating diabetes precious jade medicine compound broadleaf globethistle inflorescence tablet it is a still further object of the present invention to provide a kind of, by broadleaf globethistle inflorescence and
Rice-pudding cake leaf or root, fevervine, hair leaf xanthate compatibility have synergy, and significant in efficacy, effect is good, can restore glycometabolism rapidly
Function reduces blood fat, promotes insulin secretion, keeps glucostasis.
It is a still further object of the present invention to provide a kind of preparation methods for treating diabetes precious jade medicine compound broadleaf globethistle inflorescence tablet, will
Broadleaf globethistle inflorescence and rice-pudding cake leaf or root, fevervine, hair leaf xanthate Chinese traditional medicine's extractant refluxing extraction, then used with other drug matchings,
Preparation method of the invention is simple, equipment is easy to operate, can improve the recovery rate of active constituents of medicine and the utilization rate of the energy, have
Promotional value.
In order to realize object of the present invention and further advantage, provides a kind of precious jade medicine compound that treating diabetes and chase after bone
Wind tablet, the precious jade medicine compound broadleaf globethistle inflorescence tablet include the Chinese medicine of following parts by weight：20~30 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root 10
~20 parts, 20~30 20~30 parts of part, mao leaf xanthate of fevervine, 8~18 parts of Herba Ecliptae, 5~15 parts of cudrania root, affine cudweed 3~
13 parts, 2~12 parts of lopseed, 10~20 parts of pueraria lobata, 5~15 parts of tortoiseshell, 4~15 parts of turtle shell, 2~14 parts of Semen Cuscutae, Herba Epimedii 1
6~18 parts of~10 parts, 13~28 parts of Chinese yam, 12~24 parts of radix scrophulariae, 4~16 parts of fructus amomi, 7~19 parts of Ramulus euonymi and mulberries.
Preferably, the precious jade medicine compound broadleaf globethistle inflorescence tablet of the treatment diabetes, the precious jade medicine compound broadleaf globethistle inflorescence tablet
Include the Chinese medicine of following parts by weight：3~17 parts of 23~27 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 23~27 part, mao leaf xanthate of fevervine
23~27 parts, 11~15 parts of Herba Ecliptae, 8~12 parts of cudrania root, 6~10 parts of affine cudweed, 5~9 parts of lopseed, pueraria lobata 13~17
Part, 8~12 parts of tortoiseshell, 7~12 parts of turtle shell, 5~11 parts of Semen Cuscutae, 4~7 parts of Herba Epimedii, 10~25 parts of Chinese yam, radix scrophulariae 15~21
Part, 7~13 parts of fructus amomi, 10~16 parts of Ramulus euonymi and 9~15 parts of mulberries.
Preferably, the precious jade medicine compound broadleaf globethistle inflorescence tablet of the treatment diabetes, the precious jade medicine compound broadleaf globethistle inflorescence tablet
Include the Chinese medicine of following parts by weight：10 parts of 25 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 25 25 parts of part, mao leaf xanthate of fevervine, Herba Ecliptae
13 parts, 10 parts of cudrania root, 8 parts of affine cudweed, 7 parts of lopseed, 15 parts of pueraria lobata, 10 parts of tortoiseshell, 10 parts of turtle shell, 8 parts of Semen Cuscutae, excessive sheep
11 parts of 6 parts of the leaves of pulse plants, 13 parts of Chinese yam, 18 parts of radix scrophulariae, 10 parts of fructus amomi, 13 parts of Ramulus euonymi and mulberries.
A further object of the invention can also further be chased after the system of wind tablet by a kind of precious jade medicine compound for treating diabetes
Preparation Method is realized, is included the following steps：
Step a, by the pueraria lobata of above-mentioned parts by weight, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, ghost
Fletching and mulberries crush respectively, mixing be placed on 2~4 times amount clear water in impregnate 2~4h, filtering, detach the first filter residue and
First filter residue is divided into three parts by the first filtrate by 2: 2: 6 mass ratio, and number is mixture A, mixture B and mixture
The ethanol solution that ethyl alcohol is configured to 70~80% is added into first filtrate, obtains extractant by C；
Step b, it by the broadleaf globethistle inflorescence of above-mentioned parts by weight, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, wears out
Stone, affine cudweed and lopseed mix with the mixture C obtained in step a, are placed in multifunctional extracting pot, to the multifunctional extracting pot
The middle ethyl alcohol that 1~3 times of amount is added, heating are evaporated ethyl alcohol, and the extractant obtained in the step a of 5~7 times of amounts, reflux is then added
Extraction 1~3 time merges extracting solution, collects the extraction slag in multifunctional extracting pot, obtains the second filter residue；
Step c, the second filter residue obtained in step b is mixed with the mixture A, is placed in the leakage cylinder of washing tank, and
The ethanol solution that the mass concentration of 1~2 times of amount is 40~50% is added, stirs 20~30min, then carries the leakage cylinder upwards
It rises, the leakage cylinder is made not contacted with ethanol solution, squeeze the washed-residue on the leakage cylinder, wash repeatedly 1~3 time, merge washing
Liquid collects the washed-residue, obtains third filter residue；
Step d, it takes the extracting solution obtained in step b to be filtered twice with non-woven fabrics, then adds hydrochloric acid tune pH value 5.5~6.0,
After standing 1~3h, with micro porous filtration membrane filtration, into filtrate plus sodium hydroxide tune pH value 7.5~8.0, then after standing 1~3h,
With micro porous filtration membrane filtration, collects filtered extracting solution and mixed with the cleaning solution obtained in step c, be placed in Three-effect concentration device
Middle concentration obtains the medicinal extract that relative density is 1.07~1.12；
Step e, the medicinal extract obtained in step d is mixed into obtain mixed material with the mixture B and the third filter residue, put
Enter in 60 DEG C of jade articles, the temperature of the jade articles, which is cooled to room temperature, takes out the mixed material, and the jade articles are heated
It to 60 DEG C, is placed again into the mixed material and is down to room temperature naturally, then take out drying, be granulated, label is obtained through tabletting machine；
Step f, weigh 60~80 parts by weight gelatin be added 30~40 parts by weight water make its expansion, then be added 15~
The glycerine of 20 parts by weight and the tea oil of 10~15 parts by weight are mixed and heated to 60~80 DEG C, after being uniformly mixed, and are protected at 60 DEG C
1~2h of temperature, then filters to obtain coating agent；
Step g, the coating agent that label, pharmaceutically acceptable auxiliary material and step f that step e is obtained obtain is placed in flaker
In precious jade medicine compound broadleaf globethistle inflorescence tablet is made.
Preferably, the preparation method of the precious jade medicine compound broadleaf globethistle inflorescence tablet of the treatment diabetes, the washing tank
Tank body is cylindrical-shaped structure, the tank interior be equipped with successively from top to bottom first body of rod, two second bodies of rod, round plate body and
The leakage cylinder：
First body of rod is the loop bar that can be stretched up and down, and the loop bar is by the hollow connecting rod of at least two sections successively fitting
It forms, the upper end of the connecting rod for being located at the top is connect with the top bearing of the tank body, is located at the company of bottom
The outer wall upper edge of extension bar is axially arranged with groove；
The first end of described two second bodies of rod is flexibly connected with a sliding block, and the sliding block can be in the groove up and down
The second end of sliding, described two second bodies of rod is hinged with the upper surface of the round plate body respectively；
The circle plate body includes two semicircle plate bodys, described two semicircle plate bodys with positioned at the described of bottom
The lower end of connecting rod is hinged so that the angle of the upper surface of described two semicircle plate bodys can be at 0~240 °, when described two half
When the upper surface of round plate body forms 180 ° of angles, horizontal plane is formed；
The leakage cylinder is cylindrical-shaped structure, can slide up and down and connect with the inner tank wall, the leakage cylinder and the tank
The diameter ratio of body is 1: 1.1~1.2, and the leakage cylinder is 1: 2~3 with the tank body height ratio.
Preferably, the preparation method of the precious jade medicine compound broadleaf globethistle inflorescence tablet of the treatment diabetes, the semicircular plate
The radius of body and the radius ratio of the leakage cylinder are 0.9: 1.
Preferably, the preparation method of the precious jade medicine compound broadleaf globethistle inflorescence tablet of the treatment diabetes, the washing tank
Bottom is equipped with screen pack, and the top of the washing tank is equipped with feeding port, and lower part is equipped with liquid outlet.
Preferably, the preparation method of the precious jade medicine compound broadleaf globethistle inflorescence tablet of the treatment diabetes, the pharmacy can connect
The auxiliary material received is one or more in corn flour, calcium silicates, sodium carboxymethylcellulose, myristyl alcohol, fish glue, talcum.
The present invention includes at least following advantageous effect：
The first, the present invention plays the role of good promoting blood circulation and removing blood stasis and nourishing qi and blood using broadleaf globethistle inflorescence, and rice-pudding cake leaf or root have
Clearing heat and promoting fluid, cooling blood and hemostasis, diuresis and other effects, fevervine have expelling wind and removing dampness, analgesic antidotal, promoting digestion and removing indigestion and other effects, Mao Ye
Xanthate energy reducing blood lipid promotes islet secretion, four traditional Chinese medicine material and Herba Ecliptae, cudrania root, affine cudweed and lopseed compatible use, can
Rapid to restore function carbohydrate metabolism, thrombus, dredging and softening blood vessel adjust blood glucose, keep glucostasis；
The second, the present invention is also collocated with pueraria lobata, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, Ramulus euonymi
With the Chinese medicine of mulberries, pueraria lobata：Sweet in flavor, pungent, expelling pathogenic factors from muscles and skin is brought down a fever；Tortoiseshell：Mild-natured, sweet in flavor, nourishing and suppressing Yang, kidney-nourishing builds bone；Turtle shell：Taste
At mild-natured, clearing away heat and alleviating pain；Semen Cuscutae：It is warm-natured, it is sweet in flavor, it is nourishing liver and kidney；Herba Epimedii：Sweet and neutral, blood pressure lowering, reducing blood lipid, the anti-rhythm of the heart
It is not normal, increase cerebral blood flow (CBF)；Chinese yam：Sweet and neutral, tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying；Radix scrophulariae：Bitter is slightly cold, expansion hat
Shape artery, enriching yin, fall fire；Fructus amomi, warm-natured, acrid flavour are amusing with stomach in promoting the circulation of qi tune；Ramulus euonymi, bitter is cold in nature, promoting circulation of blood promoting menstruation,
Removing blood stasis and analgesics；Nourishing yin and nourishing blood is apt in mulberries, acid sweet in flavor, cold in nature, liver-kidney tonifying, ease constipation of promoting the production of body fluid；Collocation uses significant in efficacy, cost
It is low；
Third, the present invention are by pueraria lobata, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, Ramulus euonymi and mulberries
Impregnate preliminary extraction effective component of chinese medicine with clear water, the filter residue after immersion be divided into different three parts of ratio, different phase with
Broadleaf globethistle inflorescence, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, cudrania root, the Traditional Chinese drug mixture of affine cudweed and lopseed are mixed
It closes so that the active ingredient of two class medicinal material mixtures largely mutually merges；
4th, with the liquid dosage ethanol solution for impregnating Chinese medicine, broadleaf globethistle inflorescence, rice-pudding cake leaf or root, fevervine, Mao Ye are used for
Xanthate, Herba Ecliptae, cudrania root, affine cudweed and the refluxing extraction of lopseed active ingredient, originally carrying containing effective component of chinese medicine
Liquid is taken to promote in broadleaf globethistle inflorescence, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, cudrania root, affine cudweed and lopseed effectively
The dissolution of substance, and be conducive to the mutual fusion of every Chinese medicine；
5th, also contain mass efficient substance after refluxing extraction in remaining Chinese medicine slag, extraction slag is mixed with mixture A
It is placed in washing tank, ethanol solution is added, is sufficiently stirred, squeeze separation, recycle cleaning solution, improve the receipts of Chinese medicine active ingredient
Collection rate so that the recovery rate and utilization rate of the active constituents of medicine of Chinese medicine, which reach, to be maximized；
6th, extracting solution is first removed dregs of a decoction bits by the present invention twice with nonwoven gauze filtering, by the acid for adjusting extracting solution
Alkalinity uses micro porous filtration membrane filtration under solutions of weak acidity and weak basic condition respectively, can reduce highly acid in extracting solution and
The content of strong alkaline substance to reduce the irritation of extracting solution, while can remove unwanted impurity, reach the effect of purification
Fruit；
7th, first body of rod in the washing tank that designs of the present invention is that loop bar can be shunk up and down, when being easy to use operation and
Storage when not in use, second body of rod drives two semicircle plate body rotations under the movement of sliding block, so as to adjust two
The angle of the upper surface of semicircle plate body, when sliding block is moved to extreme higher position, the angle of the upper surface of two semicircle plate bodys
It is 0 °, realizes function convenient for collecting；When sliding block moves down in a groove, the angle of the upper surface of two semicircle plate bodys
Gradually increasing, when increasing to 180 °, two semicircular plate bodies form a horizontal plane, and first body of rod moves down at this time,
Leakage cylinder moves up, and two semicircle plate bodys have the ethanol solution of lower part downward pressure so that cleaning solution discharge rate adds
Soon, working efficiency is improved, while the washed-residue on leakage cylinder can be squeezed, improves the collection rate of cleaning solution；When sliding block is moved to most
When lower position, the angle of the upper surface of two semicircle plate bodys is 240 ° maximum, and first body of rod is moved to suitable position, two and half
Round plate body under the rotation of first body of rod can to leakage cylinder in the dregs of a decoction and ethanol solution be stirred, function diversification, section
About space, high degree of automation can largely extract the active ingredient in slag in advance and mixing A；
8th, infrared ray during jade articles can emit under thermal condition mixes medicinal extract, mixture B and third filter residue
It is put into afterwards in 60 DEG C of jade articles, it is total that the drug ingedient in medicinal extract, mixture B and third filter residue generates molecule in middle infrared ray
It shakes, the fusion of active principle can be promoted, repeat, to jade articles heating Temperature fall, to ensure effective component of chinese medicine non-inactivation；
9th, package gelatine glaze agent and pharmaceutically acceptable auxiliary material outside Chinese medical extract label of the invention, are made
Piece type, takes convenient for patient, has certain slow releasing function to drug, and will not interfere the dissolution and absorption of drug.
Part is illustrated to embody by further advantage, target and the feature of the present invention by following, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Description of the drawings
Fig. 1 is the structural schematic diagram of heretofore described washing tank；
Fig. 2 is the structural representation that heretofore described circular slab is connect with first body of rod and described two second bodies of rod
Figure.
Specific implementation mode：
With reference to embodiment, the present invention is described in further detail, to enable those skilled in the art with reference to specification
Word can be implemented according to this.
<Embodiment 1>
A kind of precious jade medicine compound broadleaf globethistle inflorescence tablet for treating diabetes, the precious jade medicine compound broadleaf globethistle inflorescence tablet includes following weight
The Chinese medicine of part：10 parts of 20 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 20 20 parts of part, mao leaf xanthate of fevervine, 8 parts of Herba Ecliptae, cudrania root 5
Part, 3 parts of affine cudweed, 2 parts of lopseed, 10 parts of pueraria lobata, 5 parts of tortoiseshell, 4 parts of turtle shell, 2 parts of Semen Cuscutae, 1 part of Herba Epimedii, 13 parts of Chinese yam,
6 parts of 12 parts of radix scrophulariae, 4 parts of fructus amomi, 7 parts of Ramulus euonymi and mulberries.
A kind of preparation method of the compound broadleaf globethistle inflorescence tablet of precious jade medicine that treating diabetes, includes the following steps：
Step a, by the pueraria lobata of above-mentioned parts by weight, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, ghost
Fletching and mulberries crush respectively, and mixing, which is placed in the clear water of 2 times of amounts, impregnates 2h, filters, and detach to obtain the first filter residue and the first filter
First filter residue is divided into three parts by liquid by 2: 2: 6 mass ratio, and number is mixture A, mixture B and mixture C, to institute
It states and the ethanol solution that ethyl alcohol is configured to 70% is added in the first filtrate, obtain extractant；
Step b, it by the broadleaf globethistle inflorescence of above-mentioned parts by weight, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, wears out
Stone, affine cudweed and lopseed mix with the mixture C obtained in step a, are placed in multifunctional extracting pot, to the multifunctional extracting pot
The middle ethyl alcohol that 1 times of amount is added, heating are evaporated ethyl alcohol, and the extractant obtained in the step a of 5 times of amounts, refluxing extraction 1 is then added
It is secondary, merge extracting solution, collects the extraction slag in multifunctional extracting pot, obtain the second filter residue；
Step c, the second filter residue obtained in step b is mixed with the mixture A, is placed in the leakage cylinder 7 of washing tank, and
The ethanol solution that the mass concentration of 1 times of amount is 40% is added, stirs 20min, is then lifted up the leakage cylinder 7, makes described
Leakage cylinder 7 is not contacted with ethanol solution, is squeezed the washed-residue on the leakage cylinder 7, is washed repeatedly 1 time, merging cleaning solution, described in collection
Washed-residue obtains third filter residue；
Wherein, the tank body of the washing tank is cylindrical-shaped structure, and the tank interior is equipped with the first bar successively from top to bottom
4, two second bodies of rod 6 of body, round plate body 5 and the leakage cylinder 7：
First body of rod 4 is the loop bar that can be stretched up and down, and the loop bar is covered successively by the hollow connecting rod of at least two sections
It closes, operation and storage when not in use, are located at the upper end of the connecting rod of the top and the tank body when being easy to use
The connection of top bearing, the outer wall upper edge positioned at the connecting rod of bottom is axially arranged with groove 3；
The first end of described two second bodies of rod 6 is flexibly connected with a sliding block 8, and the sliding block 8 can be in the groove 3
It slides up and down, the second end of described two second bodies of rod 6 is hinged with the upper surface of the round plate body 5 respectively, and second body of rod 6 exists
Two semicircle plate bodys rotations are driven under the movement of sliding block 8, so as to adjust two semicircle plate bodys upper surface angle；
The circle plate body 5 includes two semicircle plate bodys, described two semicircle plate bodys with the institute positioned at bottom
The lower end for stating connecting rod is hinged so that the angle of the upper surface of described two semicircle plate bodys can be at 0~240 °, when described two
When the upper surface of semicircle plate body forms 180 ° of angles, horizontal plane is formed convenient for squeezing the washed-residue on leakage cylinder 7；
The leakage cylinder 7 be cylindrical-shaped structure, can slide up and down and connect with the inner tank wall, the leakage cylinder 7 with it is described
The diameter ratio of tank body is 1: 1.1~1.2, and the leakage cylinder 7 is 1: 2~3 with the tank body height ratio, the half of the semicircle plate body
The radius ratio of diameter and the leakage cylinder 7 is 0.9: 1；
The bottom of the washing tank is equipped with screen pack, and the top of the washing tank is equipped with feeding port 1, and lower part is equipped with out liquid
Mouth 2.
Step d, it takes the extracting solution obtained in step b to be filtered twice with non-woven fabrics, removes dregs of a decoction bits, then add hydrochloric acid tune pH
Value 5.5 after standing 1h, with micro porous filtration membrane filtration, into filtrate plus sodium hydroxide tune pH value 7.5, then after standing 1h, uses micropore
Membrane filtration is filtered, by adjusting the acid-base property of extracting solution, uses micropore filtering film under solutions of weak acidity and weak basic condition respectively
Filtering, can reduce the content of the highly acid and strong alkaline substance in extracting solution, to reduce the irritation of extracting solution, while can be with
Unwanted impurity is removed, achievees the effect that purification, collect filtered extracting solution and is mixed with the cleaning solution obtained in step c
It closes, is placed in Three-effect concentration device and concentrates, obtain the medicinal extract that relative density is 1.07；
Step e, the medicinal extract obtained in step d is mixed into obtain mixed material with the mixture B and the third filter residue, put
Enter in 60 DEG C of jade articles, the temperature of the jade articles, which is cooled to room temperature, takes out the mixed material, and the jade articles are heated
It to 60 DEG C, is placed again into the mixed material and is down to room temperature naturally, then take out drying, be granulated, label is obtained through tabletting machine,
Drug ingedient in medicinal extract, mixture B and third filter residue generates molecular resonance in middle infrared ray, can promote active principle
Fusion repeats, to jade articles heating Temperature fall, to ensure effective component of chinese medicine non-inactivation；
Step f, weighing the water of gelatin 30 parts by weight of addition of 60 parts by weight makes its expansion, and the sweet of 15 parts by weight is then added
Oil and the tea oil of 10 parts by weight are mixed and heated to 60 DEG C, after being uniformly mixed, and 1h is kept the temperature at 60 DEG C, then filter to obtain coating
Agent；
Step g, the coating for obtaining label, corn flour, calcium silicates, myristyl alcohol, talcum and step f that step e is obtained
Agent, which is placed in flaker, is made precious jade medicine compound broadleaf globethistle inflorescence tablet, is taken convenient for patient, has certain slow releasing function to drug, and will not
Interfere the dissolution and absorption of drug.
<Embodiment 2>
A kind of precious jade medicine compound broadleaf globethistle inflorescence tablet for treating diabetes, the precious jade medicine compound broadleaf globethistle inflorescence tablet includes following weight
The Chinese medicine of part：3 parts of 23 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 23 23 parts of part, mao leaf xanthate of fevervine, 11 parts of Herba Ecliptae, cudrania root 8
Part, 6 parts of affine cudweed, 5 parts of lopseed, 13 parts of pueraria lobata, 8 parts of tortoiseshell, 7 parts of turtle shell, 5 parts of Semen Cuscutae, 4 parts of Herba Epimedii, 10 parts of Chinese yam,
9 parts of 15 parts of radix scrophulariae, 7 parts of fructus amomi, 10 parts of Ramulus euonymi and mulberries.
A kind of preparation method of the compound broadleaf globethistle inflorescence tablet of precious jade medicine that treating diabetes, includes the following steps：
Step a, by the pueraria lobata of above-mentioned parts by weight, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, ghost
Fletching and mulberries crush respectively, and mixing, which is placed in the clear water of 2 times of amounts, impregnates 2h, filters, and detach to obtain the first filter residue and the first filter
First filter residue is divided into three parts by liquid by 2: 2: 6 mass ratio, and number is mixture A, mixture B and mixture C, to institute
It states and the ethanol solution that ethyl alcohol is configured to 70% is added in the first filtrate, obtain extractant；
Step b, it by the broadleaf globethistle inflorescence of above-mentioned parts by weight, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, wears out
Stone, affine cudweed and lopseed mix with the mixture C obtained in step a, are placed in multifunctional extracting pot, to the multifunctional extracting pot
The middle ethyl alcohol that 1 times of amount is added, heating are evaporated ethyl alcohol, and the extractant obtained in the step a of 5 times of amounts, refluxing extraction 1 is then added
Secondary, merging obtains extracting solution, collects the extraction slag in multifunctional extracting pot, obtains the second filter residue；
Step c, the second filter residue obtained in step b is mixed with the mixture A, is placed in the leakage cylinder 7 of washing tank, and
The ethanol solution that the mass concentration of 1 times of amount is 40% is added, stirs 20min, is then lifted up the leakage cylinder 7, makes described
Leakage cylinder 7 is not contacted with ethanol solution, is squeezed the washed-residue on the leakage cylinder 7, is washed repeatedly 1 time, merging cleaning solution, described in collection
Washed-residue obtains third filter residue；
Wherein, the tank body of the washing tank is cylindrical-shaped structure, and the tank interior is equipped with the first bar successively from top to bottom
4, two second bodies of rod 6 of body, round plate body 5 and the leakage cylinder 7：
First body of rod 4 is the loop bar that can be stretched up and down, and the loop bar is covered successively by the hollow connecting rod of at least two sections
It closes, operation and storage when not in use, are located at the upper end of the connecting rod of the top and the tank body when being easy to use
The connection of top bearing, the outer wall upper edge positioned at the connecting rod of bottom is axially arranged with groove 3；
The first end of described two second bodies of rod 6 is flexibly connected with a sliding block 8, and the sliding block 8 can be in the groove 3
It slides up and down, the second end of described two second bodies of rod 6 is hinged with the upper surface of the round plate body 5 respectively, and second body of rod 6 exists
Two semicircle plate bodys rotations are driven under the movement of sliding block 8, so as to adjust two semicircle plate bodys upper surface angle；
The circle plate body 5 includes two semicircle plate bodys, described two semicircle plate bodys with the institute positioned at bottom
The lower end for stating connecting rod is hinged so that the angle of the upper surface of described two semicircle plate bodys can be at 0~240 °, when described two
When the upper surface of semicircle plate body forms 180 ° of angles, horizontal plane is formed convenient for squeezing the washed-residue on leakage cylinder 7；
The leakage cylinder 7 be cylindrical-shaped structure, can slide up and down and connect with the inner tank wall, the leakage cylinder 7 with it is described
The diameter ratio of tank body is 1: 1.1, and the leakage cylinder 7 and the tank body height ratio are 1: 2, the radius of the semicircle plate body with it is described
The radius ratio for leaking cylinder 7 is 0.9: 1；
The bottom of the washing tank is equipped with screen pack, and the top of the washing tank is equipped with feeding port 1, and lower part is equipped with out liquid
Mouth 2.
Step d, it takes the extracting solution obtained in step b to be filtered twice with non-woven fabrics, removes dregs of a decoction bits, then add hydrochloric acid tune pH
Value 5.5 after standing 1h, with micro porous filtration membrane filtration, into filtrate plus sodium hydroxide tune pH value 7.5, then after standing 1h, uses micropore
Membrane filtration is filtered, by adjusting the acid-base property of extracting solution, uses micropore filtering film under solutions of weak acidity and weak basic condition respectively
Filtering, can reduce the content of the highly acid and strong alkaline substance in extracting solution, to reduce the irritation of extracting solution, while can be with
Unwanted impurity is removed, achievees the effect that purification, collect filtered extracting solution and is mixed with the cleaning solution obtained in step c
It closes, is placed in Three-effect concentration device and concentrates, obtain the medicinal extract that relative density is 1.07；
Step e, the medicinal extract obtained in step d is mixed into obtain mixed material with the mixture B and the third filter residue, put
Enter in 60 DEG C of jade articles, the temperature of the jade articles, which is cooled to room temperature, takes out the mixed material, and the jade articles are heated
It to 60 DEG C, is placed again into the mixed material and is down to room temperature naturally, then take out drying, be granulated, label is obtained through tabletting machine,
Drug ingedient in medicinal extract, mixture B and third filter residue generates molecular resonance in middle infrared ray, can promote active principle
Fusion repeats, to jade articles heating Temperature fall, to ensure effective component of chinese medicine non-inactivation；
Step f, weighing the water of gelatin 30 parts by weight of addition of 60 parts by weight makes its expansion, and the sweet of 15 parts by weight is then added
Oil and the tea oil of 10 parts by weight are mixed and heated to 60 DEG C, after being uniformly mixed, and 1h is kept the temperature at 60 DEG C, then filter to obtain coating
Agent；
Step g, label, corn flour, sodium carboxymethylcellulose, myristyl alcohol, talcum and step f that step e is obtained are obtained
To coating agent be placed in flaker precious jade medicine compound broadleaf globethistle inflorescence tablet be made, taken convenient for patient, there is certain sustained release to make drug
With, and the dissolution and absorption of drug will not be interfered.
<Embodiment 3>
A kind of precious jade medicine compound broadleaf globethistle inflorescence tablet for treating diabetes, the precious jade medicine compound broadleaf globethistle inflorescence tablet includes following weight
The Chinese medicine of part：17 parts of 27 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 27 27 parts of part, mao leaf xanthate of fevervine, 15 parts of Herba Ecliptae, cudrania root
12 parts, 10 parts of affine cudweed, 9 parts of lopseed, 17 parts of pueraria lobata, 12 parts of tortoiseshell, 12 parts of turtle shell, 11 parts of Semen Cuscutae, 7 parts of Herba Epimedii, mountain
15 parts of 25 parts of medicine, 21 parts of radix scrophulariae, 13 parts of fructus amomi, 16 parts of Ramulus euonymi and mulberries.
A kind of preparation method of the compound broadleaf globethistle inflorescence tablet of precious jade medicine that treating diabetes, includes the following steps：
Step a, by the pueraria lobata of above-mentioned parts by weight, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, ghost
Fletching and mulberries crush respectively, and mixing, which is placed in the clear water of 4 times of amounts, impregnates 4h, filters, and detach to obtain the first filter residue and the first filter
First filter residue is divided into three parts by liquid by 2: 2: 6 mass ratio, and number is mixture A, mixture B and mixture C, to institute
It states and the ethanol solution that ethyl alcohol is configured to 80% is added in the first filtrate, obtain extractant；
Step b, it by the broadleaf globethistle inflorescence of above-mentioned parts by weight, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, wears out
Stone, affine cudweed and lopseed mix with the mixture C obtained in step a, are placed in multifunctional extracting pot, to the multifunctional extracting pot
The middle ethyl alcohol that 3 times of amounts are added, heating are evaporated ethyl alcohol, and the extractant obtained in the step a of 7 times of amounts, refluxing extraction 3 is then added
Secondary, merging obtains extracting solution, collects the extraction slag in multifunctional extracting pot, obtains the second filter residue；
Step c, the second filter residue obtained in step b is mixed with the mixture A, is placed in the leakage cylinder 7 of washing tank, and
The ethanol solution that the mass concentration of 2 times of amounts is 50% is added, stirs 30min, is then lifted up the leakage cylinder 7, makes described
Leakage cylinder 7 is not contacted with ethanol solution, is squeezed the washed-residue on the leakage cylinder 7, is washed repeatedly 3 times, merging cleaning solution, described in collection
Washed-residue obtains third filter residue；
Wherein, the tank body of the washing tank is cylindrical-shaped structure, and the tank interior is equipped with the first bar successively from top to bottom
4, two second bodies of rod 6 of body, round plate body 5 and the leakage cylinder 7：
First body of rod 4 is the loop bar that can be stretched up and down, and the loop bar is covered successively by the hollow connecting rod of at least two sections
It closes, operation and storage when not in use, are located at the upper end of the connecting rod of the top and the tank body when being easy to use
The connection of top bearing, the outer wall upper edge positioned at the connecting rod of bottom is axially arranged with groove 3；
The first end of described two second bodies of rod 6 is flexibly connected with a sliding block 8, and the sliding block 8 can be in the groove 3
It slides up and down, the second end of described two second bodies of rod 6 is hinged with the upper surface of the round plate body 5 respectively, and second body of rod 6 exists
Two semicircle plate bodys rotations are driven under the movement of sliding block 8, so as to adjust two semicircle plate bodys upper surface angle；
The circle plate body 5 includes two semicircle plate bodys, described two semicircle plate bodys with the institute positioned at bottom
The lower end for stating connecting rod is hinged so that the angle of the upper surface of described two semicircle plate bodys can be at 0~240 °, when described two
When the upper surface of semicircle plate body forms 180 ° of angles, horizontal plane is formed convenient for squeezing the washed-residue on leakage cylinder 7；
The leakage cylinder 7 be cylindrical-shaped structure, can slide up and down and connect with the inner tank wall, the leakage cylinder 7 with it is described
The diameter ratio of tank body is 1: 1.2, and the leakage cylinder 7 and the tank body height ratio are 1: 3, the radius of the semicircle plate body with it is described
The radius ratio for leaking cylinder 7 is 0.9: 1；
The bottom of the washing tank is equipped with screen pack, and the top of the washing tank is equipped with feeding port 1, and lower part is equipped with out liquid
Mouth 2.
Step d, it takes the extracting solution obtained in step b to be filtered twice with non-woven fabrics, removes dregs of a decoction bits, then add hydrochloric acid tune pH
Value 6.0 after standing 3h, with micro porous filtration membrane filtration, into filtrate plus sodium hydroxide tune pH value 8.0, then after standing 3h, uses micropore
Membrane filtration is filtered, by adjusting the acid-base property of extracting solution, uses micropore filtering film under solutions of weak acidity and weak basic condition respectively
Filtering, can reduce the content of the highly acid and strong alkaline substance in extracting solution, to reduce the irritation of extracting solution, while can be with
Unwanted impurity is removed, achievees the effect that purification, collect filtered extracting solution and is mixed with the cleaning solution obtained in step c
It closes, is placed in Three-effect concentration device and concentrates, obtain the medicinal extract that relative density is 1.12；
Step e, the medicinal extract obtained in step d is mixed into obtain mixed material with the mixture B and the third filter residue, put
Enter in 60 DEG C of jade articles, the temperature of the jade articles, which is cooled to room temperature, takes out the mixed material, and the jade articles are heated
It to 60 DEG C, is placed again into the mixed material and is down to room temperature naturally, then take out drying, be granulated, label is obtained through tabletting machine,
Drug ingedient in medicinal extract, mixture B and third filter residue generates molecular resonance in middle infrared ray, can promote active principle
Fusion repeats, to jade articles heating Temperature fall, to ensure effective component of chinese medicine non-inactivation；
Step f, weighing the water of gelatin 40 parts by weight of addition of 80 parts by weight makes its expansion, and the sweet of 20 parts by weight is then added
Oil and the tea oil of 15 parts by weight are mixed and heated to 80 DEG C, after being uniformly mixed, and 2h is kept the temperature at 60 DEG C, then filter to obtain coating
Agent；
Step g, the obtained coating agent of label, corn flour, calcium silicates, fish glue, talcum and step f that step e is obtained is set
Precious jade medicine compound broadleaf globethistle inflorescence tablet is made in flaker, is taken convenient for patient, has certain slow releasing function to drug, and will not interfere
The dissolution and absorption of drug.
<Embodiment 4>
A kind of precious jade medicine compound broadleaf globethistle inflorescence tablet for treating diabetes, the precious jade medicine compound broadleaf globethistle inflorescence tablet includes following weight
The Chinese medicine of part：20 parts of 30 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 30 30 parts of part, mao leaf xanthate of fevervine, 18 parts of Herba Ecliptae, cudrania root
15 parts, 13 parts of affine cudweed, 12 parts of lopseed, 20 parts of pueraria lobata, 15 parts of tortoiseshell, 15 parts of turtle shell, 14 parts of Semen Cuscutae, 10 parts of Herba Epimedii,
18 parts of 28 parts of Chinese yam, 24 parts of radix scrophulariae, 16 parts of fructus amomi, 19 parts of Ramulus euonymi and mulberries.
A kind of preparation method of the compound broadleaf globethistle inflorescence tablet of precious jade medicine that treating diabetes, includes the following steps：
Step a, by the pueraria lobata of above-mentioned parts by weight, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, ghost
Fletching and mulberries crush respectively, and mixing, which is placed in the clear water of 4 times of amounts, impregnates 4h, filters, and detach to obtain the first filter residue and the first filter
First filter residue is divided into three parts by liquid by 2: 2: 6 mass ratio, and number is mixture A, mixture B and mixture C, to institute
It states and the ethanol solution that ethyl alcohol is configured to 80% is added in the first filtrate, obtain extractant；
Step b, it by the broadleaf globethistle inflorescence of above-mentioned parts by weight, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, wears out
Stone, affine cudweed and lopseed mix with the mixture C obtained in step a, are placed in multifunctional extracting pot, to the multifunctional extracting pot
The middle ethyl alcohol that 3 times of amounts are added, heating are evaporated ethyl alcohol, and the extractant obtained in the step a of 7 times of amounts, refluxing extraction 3 is then added
Secondary, merging obtains extracting solution, collects the extraction slag in multifunctional extracting pot, obtains the second filter residue；
Step c, the second filter residue obtained in step b is mixed with the mixture A, is placed in the leakage cylinder 7 of washing tank, and
The ethanol solution that the mass concentration of 2 times of amounts is 50% is added, stirs 30min, is then lifted up the leakage cylinder 7, makes described
Leakage cylinder 7 is not contacted with ethanol solution, is squeezed the washed-residue on the leakage cylinder 7, is washed repeatedly 3 times, merging cleaning solution, described in collection
Washed-residue obtains third filter residue；
Wherein, the tank body of the washing tank is cylindrical-shaped structure, and the tank interior is equipped with the first bar successively from top to bottom
4, two second bodies of rod 6 of body, round plate body 5 and the leakage cylinder 7：
First body of rod 4 is the loop bar that can be stretched up and down, and the loop bar is covered successively by the hollow connecting rod of at least two sections
It closes, operation and storage when not in use, are located at the upper end of the connecting rod of the top and the tank body when being easy to use
The connection of top bearing, the outer wall upper edge positioned at the connecting rod of bottom is axially arranged with groove 3；
The first end of described two second bodies of rod 6 is flexibly connected with a sliding block 8, and the sliding block 8 can be in the groove 3
It slides up and down, the second end of described two second bodies of rod 6 is hinged with the upper surface of the round plate body 5 respectively, and second body of rod 6 exists
Two semicircle plate bodys rotations are driven under the movement of sliding block 8, so as to adjust two semicircle plate bodys upper surface angle；
The circle plate body 5 includes two semicircle plate bodys, described two semicircle plate bodys with the institute positioned at bottom
The lower end for stating connecting rod is hinged so that the angle of the upper surface of described two semicircle plate bodys can be at 0~240 °, when described two
When the upper surface of semicircle plate body forms 180 ° of angles, horizontal plane is formed convenient for squeezing the washed-residue on leakage cylinder 7；
The leakage cylinder 7 be cylindrical-shaped structure, can slide up and down and connect with the inner tank wall, the leakage cylinder 7 with it is described
The diameter ratio of tank body is 1: 1.2, and the leakage cylinder 7 and the tank body height ratio are 1: 3, the radius of the semicircle plate body with it is described
The radius ratio for leaking cylinder 7 is 0.9: 1；
The bottom of the washing tank is equipped with screen pack, and the top of the washing tank is equipped with feeding port 1, and lower part is equipped with out liquid
Mouth 2.
Step d, it takes the extracting solution obtained in step b to be filtered twice with non-woven fabrics, removes dregs of a decoction bits, then add hydrochloric acid tune pH
Value 6.0 after standing 3h, with micro porous filtration membrane filtration, into filtrate plus sodium hydroxide tune pH value 8.0, then after standing 3h, uses micropore
Membrane filtration is filtered, by adjusting the acid-base property of extracting solution, uses micropore filtering film under solutions of weak acidity and weak basic condition respectively
Filtering, can reduce the content of the highly acid and strong alkaline substance in extracting solution, to reduce the irritation of extracting solution, while can be with
Unwanted impurity is removed, achievees the effect that purification, collect filtered extracting solution and is mixed with the cleaning solution obtained in step c
It closes, is placed in Three-effect concentration device and concentrates, obtain the medicinal extract that relative density is 1.12；
Step e, the medicinal extract obtained in step d is mixed into obtain mixed material with the mixture B and the third filter residue, put
Enter in 60 DEG C of jade articles, the temperature of the jade articles, which is cooled to room temperature, takes out the mixed material, and the jade articles are heated
It to 60 DEG C, is placed again into the mixed material and is down to room temperature naturally, then take out drying, be granulated, label is obtained through tabletting machine,
Drug ingedient in medicinal extract, mixture B and third filter residue generates molecular resonance in middle infrared ray, can promote active principle
Fusion repeats, to jade articles heating Temperature fall, to ensure effective component of chinese medicine non-inactivation；
Step f, weighing the water of gelatin 40 parts by weight of addition of 80 parts by weight makes its expansion, and the sweet of 20 parts by weight is then added
Oil and the tea oil of 15 parts by weight are mixed and heated to 80 DEG C, after being uniformly mixed, and 2h is kept the temperature at 60 DEG C, then filter to obtain coating
Agent；
Step g, label, corn flour, calcium silicates, sodium carboxymethylcellulose, talcum and step f that step e is obtained are obtained
Coating agent be placed in flaker precious jade medicine compound broadleaf globethistle inflorescence tablet be made, taken convenient for patient, have certain slow releasing function to drug,
The dissolution and absorption of drug will not be interfered again.
<Embodiment 5>
A kind of precious jade medicine compound broadleaf globethistle inflorescence tablet for treating diabetes, the precious jade medicine compound broadleaf globethistle inflorescence tablet includes following weight
The Chinese medicine of part：10 parts of 25 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 25 25 parts of part, mao leaf xanthate of fevervine, 13 parts of Herba Ecliptae, cudrania root
10 parts, 8 parts of affine cudweed, 7 parts of lopseed, 15 parts of pueraria lobata, 10 parts of tortoiseshell, 10 parts of turtle shell, 8 parts of Semen Cuscutae, 6 parts of Herba Epimedii, Chinese yam
11 parts of 13 parts, 18 parts of radix scrophulariae, 10 parts of fructus amomi, 13 parts of Ramulus euonymi and mulberries.
A kind of preparation method of the compound broadleaf globethistle inflorescence tablet of precious jade medicine that treating diabetes, includes the following steps：
Step a, by the pueraria lobata of above-mentioned parts by weight, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, ghost
Fletching and mulberries crush respectively, and mixing, which is placed in the clear water of 3 times of amounts, impregnates 3h, filters, and detach to obtain the first filter residue and the first filter
First filter residue is divided into three parts by liquid by 2: 2: 6 mass ratio, and number is mixture A, mixture B and mixture C, to institute
It states and the ethanol solution that ethyl alcohol is configured to 75% is added in the first filtrate, obtain extractant；
Step b, it by the broadleaf globethistle inflorescence of above-mentioned parts by weight, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, wears out
Stone, affine cudweed and lopseed mix with the mixture C obtained in step a, are placed in multifunctional extracting pot, to the multifunctional extracting pot
The middle ethyl alcohol that 2 times of amounts are added, heating are evaporated ethyl alcohol, and the extractant obtained in the step a of 6 times of amounts, refluxing extraction 2 is then added
Secondary, merging obtains extracting solution, collects the extraction slag in multifunctional extracting pot, obtains the second filter residue；
Step c, the second filter residue obtained in step b is mixed with the mixture A, is placed in the leakage cylinder 7 of washing tank, and
The ethanol solution that the mass concentration of 1.5 times of amounts is 45% is added, stirs 25min, then the leakage cylinder 7 is lifted up, makes institute
It states leakage cylinder 7 not contact with ethanol solution, squeezes the washed-residue on the leakage cylinder 7, wash repeatedly 2 times, merge cleaning solution, collect institute
Washed-residue is stated, third filter residue is obtained；
Wherein, the tank body of the washing tank is cylindrical-shaped structure, and the tank interior is equipped with the first bar successively from top to bottom
4, two second bodies of rod 6 of body, round plate body 5 and the leakage cylinder 7：
First body of rod 4 is the loop bar that can be stretched up and down, and the loop bar is covered successively by the hollow connecting rod of at least two sections
It closes, operation and storage when not in use, are located at the upper end of the connecting rod of the top and the tank body when being easy to use
The connection of top bearing, the outer wall upper edge positioned at the connecting rod of bottom is axially arranged with groove 3；
The first end of described two second bodies of rod 6 is flexibly connected with a sliding block 8, and the sliding block 8 can be in the groove 3
It slides up and down, the second end of described two second bodies of rod 6 is hinged with the upper surface of the round plate body 5 respectively, and second body of rod 6 exists
Two semicircle plate bodys rotations are driven under the movement of sliding block 8, so as to adjust two semicircle plate bodys upper surface angle；
The circle plate body 5 includes two semicircle plate bodys, described two semicircle plate bodys with the institute positioned at bottom
The lower end for stating connecting rod is hinged so that the angle of the upper surface of described two semicircle plate bodys can be at 0~240 °, when described two
When the upper surface of semicircle plate body forms 180 ° of angles, horizontal plane is formed convenient for squeezing the washed-residue on leakage cylinder 7；
The leakage cylinder 7 be cylindrical-shaped structure, can slide up and down and connect with the inner tank wall, the leakage cylinder 7 with it is described
The diameter ratio of tank body is 1: 1.1, and the leakage cylinder 7 is 1: 2.5 with the tank body height ratio, the radius of the semicircle plate body and institute
The radius ratio for stating leakage cylinder 7 is 0.9: 1；
The bottom of the washing tank is equipped with screen pack, and the top of the washing tank is equipped with feeding port 1, and lower part is equipped with out liquid
Mouth 2.
Step d, it takes the extracting solution obtained in step b to be filtered twice with non-woven fabrics, removes dregs of a decoction bits, then add hydrochloric acid tune pH
Value 5.7 after standing 2h, with micro porous filtration membrane filtration, into filtrate plus sodium hydroxide tune pH value 7.8, then after standing 2h, uses micropore
Membrane filtration is filtered, by adjusting the acid-base property of extracting solution, uses micropore filtering film under solutions of weak acidity and weak basic condition respectively
Filtering, can reduce the content of the highly acid and strong alkaline substance in extracting solution, to reduce the irritation of extracting solution, while can be with
Unwanted impurity is removed, achievees the effect that purification, collect filtered extracting solution and is mixed with the cleaning solution obtained in step c
It closes, is placed in Three-effect concentration device and concentrates, obtain the medicinal extract that relative density is 1.10；
Step e, the medicinal extract obtained in step d is mixed into obtain mixed material with the mixture B and the third filter residue, put
Enter in 60 DEG C of jade articles, the temperature of the jade articles, which is cooled to room temperature, takes out the mixed material, and the jade articles are heated
It to 60 DEG C, is placed again into the mixed material and is down to room temperature naturally, then take out drying, be granulated, label is obtained through tabletting machine,
Drug ingedient in medicinal extract, mixture B and third filter residue generates molecular resonance in middle infrared ray, can promote active principle
Fusion repeats, to jade articles heating Temperature fall, to ensure effective component of chinese medicine non-inactivation；
Step f, weighing the water of gelatin 35 parts by weight of addition of 70 parts by weight makes its expansion, and the sweet of 18 parts by weight is then added
Oil and the tea oil of 13 parts by weight are mixed and heated to 70 DEG C, after being uniformly mixed, and 1.5h is kept the temperature at 60 DEG C, then filter to obtain coating
Agent；
Step g, label, corn flour, sodium carboxymethylcellulose, fish glue, talcum and step f that step e is obtained are obtained
Coating agent, which is placed in flaker, is made precious jade medicine compound broadleaf globethistle inflorescence tablet, is taken convenient for patient, has certain slow releasing function to drug, again
The dissolution and absorption of drug will not be interfered.
<Test example 1>
Animal toxicity test is reported：
After the Chinese medicinal tablet obtained in the embodiment of the present invention 5 is diluted with water, as experiment liquid；
Take the mouse 30 of half male and half female, every rabbit mouse weight is 18~22g, after fasting 12h, with above-mentioned liquid one
In a few days gavage 0.5ml/10g/ times, it is secondary daily, 7 days are even served, the reaction of observation administration daily, the results showed that in 30 mouse 7 days
Diet is normal, none dead and poisoning, it was demonstrated that drug is without bad toxic side effect.
<Comparative example 1>
Treatment of diabetes mellitus patients test report：
One, clinical observation：
1, referring to《New Chinese medicine treats diabetes guideline of clinical investigations》, accept diabetes for medical treatment and merge peripheral nerve, blood
300 people of pipe lesion patient, fasting blood-glucose take the treatment sugar obtained of embodiment 5 in the present invention at 9.1 mM/ls or more
The precious jade medicine compound broadleaf globethistle inflorescence tablet of disease is urinated, a point morning and evening takes twice, and the course for the treatment of is most 1 month short, and longest is 2 years.
Two, efficacy assessment standard：
This efficacy assessment standard is reference《New Chinese medicine guideline of clinical investigations》It formulates, specific standards are as follows：
(1) it fully recovers：Clinical symptom and sign disappears, and blood fat, blood pressure keep normal, can be as normal person one without keeping on a diet
Sample diet does not recur in 1 year；
(2) effective：Clinical symptom and sign disappears, and blood fat, blood pressure keep normal, and blood glucose is drunk after the meal close to normal range (NR) on an empty stomach
Value, in the ideal range, half a year is interior without recurrence for weight maintenance；
(3) effectively：Clinical symptom and sign disappears, and blood fat, blood pressure gradually tend to be normal, and islet function restores, without multiple in March
Hair；
(4) invalid：Clinical symptom and sign and auxiliary examination are showed no improvement.
Three, treatment results：
Table 1：Treatment results
As seen from the above table, cure rate is up to 60%, and total effective rate is up to 99%, significant in efficacy；Illustrate the Chinese medicine of the present invention
Tablet made from the preparation method of composite preparation has a better effect treatment diabetes.
<Comparative example 2>
Case 1, Mr. Wang, man, 51 years old, fasting blood sugar 17.3mmol/L.Give the Chinese medicinal tablet that the present embodiment 5 obtains
Treatment, fasting blood sugar is down to 5.4mmol/L after 4 months, and after 3 years, fasting blood sugar is down to 4.3mmol/L, and triennial extremely
The present does not take any other hypoglycemic medicine and insulin.
Case 2, poplar, man, 48 years old, diabetic history 5 years, fasting blood sugar 14.4mmol/L was obtained through giving the present embodiment 5
The Chinese medicinal tablet treatment arrived, fasting blood sugar is down to 5.6mmol/L after two months, and working of having fully recovered, follow-up is normal after 1 year.
Case 3, Mr. Wang, 30 years old, diabetic history 3 years, fasting blood sugar 14.6mmol/L, the big hemoptysis of complication pulmonary tuberculosis,
Hospital diagnosis is diabetes and complication, fasting blood sugar 15.1mmol/L.It gives the Chinese medicinal tablet that the present embodiment 5 obtains and adds west
Medicine treating pulmonery tuberculosis joins medicine treatment, and pulmonary tuberculosis has been cured after three months, does not have to Western medicine, singly gives the Chinese medicine that the present embodiment 5 obtains
Tablet in treatment, fasting blood sugar is down to 5.1mmol/L after half a year, and patient fully recovers after continual cure one month.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and embodiment shown and described herein.
Claims (5)
1. a kind of precious jade medicine compound broadleaf globethistle inflorescence tablet for treating diabetes, which is characterized in that
The precious jade medicine compound broadleaf globethistle inflorescence tablet is made of the Chinese medicine of following parts by weight：20~30 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root
10~20 parts, 20~30 20~30 parts of part, mao leaf xanthate of fevervine, 8~18 parts of Herba Ecliptae, 5~15 parts of cudrania root, affine cudweed 3
~13 parts, 2~12 parts of lopseed, 10~20 parts of pueraria lobata, 5~15 parts of tortoiseshell, 4~15 parts of turtle shell, 2~14 parts of Semen Cuscutae, excessive sheep
6~18 parts of 1~10 part of the leaves of pulse plants, 13~28 parts of Chinese yam, 12~24 parts of radix scrophulariae, 4~16 parts of fructus amomi, 7~19 parts of Ramulus euonymi and mulberries；
The precious jade medicine compound of the treatment diabetes chases after the preparation method of wind tablet, includes the following steps：
Step a, by the pueraria lobata of above-mentioned parts by weight, tortoiseshell, turtle shell, Semen Cuscutae, Herba Epimedii, Chinese yam, radix scrophulariae, fructus amomi, Ramulus euonymi
It is crushed respectively with mulberries, mixing, which is placed in the clear water of 2~4 times of amounts, impregnates 2~4h, and filtering detaches to obtain the first filter residue and first
First filter residue is pressed 2 by filtrate:2:6 mass ratio is divided into three parts, and number is mixture A, mixture B and mixture C, to
The ethanol solution that ethyl alcohol is configured to 70~80% is added in first filtrate, obtains extractant；
Step b, by the broadleaf globethistle inflorescence of above-mentioned parts by weight, rice-pudding cake leaf or root, fevervine, hair leaf xanthate, Herba Ecliptae, cudrania root, mouse
Anacamptis pyromaidalis and lopseed mix with the mixture C obtained in step a, are placed in multifunctional extracting pot, add into the multifunctional extracting pot
Enter the ethyl alcohol of 1~3 times of amount, heating is evaporated ethyl alcohol, and the extractant obtained in the step a of 5~7 times of amounts, refluxing extraction 1 is then added
~3 times, merge extracting solution, collects the extraction slag in multifunctional extracting pot, obtain the second filter residue；
Step c, the second filter residue obtained in step b is mixed with the mixture A, is placed in the leakage cylinder of washing tank, and be added 1
The ethanol solution that the mass concentration of~2 times of amounts is 40~50% stirs 20~30min, is then lifted up the leakage cylinder, makes
The leakage cylinder is not contacted with ethanol solution, is squeezed the washed-residue on the leakage cylinder, is washed repeatedly 1~3 time, merge cleaning solution, receive
Collect the washed-residue, obtains third filter residue；
Step d, it takes the extracting solution obtained in step b to be filtered twice with non-woven fabrics, then adds hydrochloric acid tune pH value 5.5~6.0, stand
After 1~3h, with micro porous filtration membrane filtration, into filtrate plus sodium hydroxide tune pH value 7.5~8.0, then after standing 1~3h, use is micro-
Membrane filtration is filtered in hole, collects filtered extracting solution and is mixed with the cleaning solution obtained in step c, is placed in dense in Three-effect concentration device
Contracting obtains the medicinal extract that relative density is 1.07~1.12；
Step e, the medicinal extract obtained in step d is mixed into obtain mixed material with the mixture B and the third filter residue, is put into 60
DEG C jade articles in, the temperature of the jade articles, which is cooled to room temperature, takes out the mixed material, and the jade articles are heated to 60
DEG C, it is placed again into the mixed material and is down to room temperature naturally, then take out drying, be granulated, label is obtained through tabletting machine；
Step f, weighing the water of gelatin 30~40 parts by weight of addition of 60~80 parts by weight makes its expansion, and 15~20 weights are then added
The tea oil of the glycerine and 10~15 parts by weight of measuring part be mixed and heated at 60~80 DEG C, after being uniformly mixed, 60 DEG C heat preservation 1~
Then 2h filters to obtain coating agent；
Step g, label that step e is obtained, pharmaceutically acceptable auxiliary material are placed in flaker with the obtained coating agents of step f and are made
Obtain precious jade medicine compound broadleaf globethistle inflorescence tablet；The tank body of the washing tank is cylindrical-shaped structure, and the tank interior is set successively from top to bottom
There are first body of rod, two second bodies of rod, round plate body and the leakage cylinder：
First body of rod is the loop bar that can be stretched up and down, the loop bar by the hollow connecting rod of at least two sections successively fitting and
At the upper end of the connecting rod for being located at the top is connect with the top bearing of the tank body, is located at the connection of bottom
The outer wall upper edge of bar is axially arranged with groove；
The first end of described two second bodies of rod is flexibly connected with a sliding block, and the sliding block upper in the groove can glide
Dynamic, the second end of described two second bodies of rod is hinged with the upper surface of the round plate body respectively；
The circle plate body includes two semicircle plate bodys, described two semicircle plate bodys with the connection positioned at bottom
The lower end of bar is hinged so that the angle of the upper surface of described two semicircle plate bodys can be at 0~240 °, when described two semicircles
When the upper surface of plate body forms 180 ° of angles, horizontal plane is formed；
The leakage cylinder is cylindrical-shaped structure, can slide up and down and connect with the inner tank wall, the leakage cylinder and the tank body
Diameter ratio is 1:1.1~1.2, the leakage cylinder is 1 with the tank body height ratio:2~3.
2. the precious jade medicine compound broadleaf globethistle inflorescence tablet for the treatment of diabetes as described in claim 1, which is characterized in that the precious jade medicine compound
Broadleaf globethistle inflorescence tablet is made of the Chinese medicine of following parts by weight：10 parts of 25 parts of broadleaf globethistle inflorescence, rice-pudding cake leaf or root, 25 parts of fevervine, Mao Ye
25 parts of xanthate, 13 parts of Herba Ecliptae, 10 parts of cudrania root, 8 parts of affine cudweed, 7 parts of lopseed, 15 parts of pueraria lobata, 10 parts of tortoiseshell, turtle shell 10
11 parts of part, 8 parts of Semen Cuscutae, 6 parts of Herba Epimedii, 13 parts of Chinese yam, 18 parts of radix scrophulariae, 10 parts of fructus amomi, 13 parts of Ramulus euonymi and mulberries.
3. as described in claim 1 treatment diabetes precious jade medicine compound broadleaf globethistle inflorescence tablet, it is described semicircle plate body radius with
The radius ratio of the leakage cylinder is 0.9:1.
4. the precious jade medicine compound broadleaf globethistle inflorescence tablet for the treatment of diabetes as claimed in claim 3, which is characterized in that the washing tank
Bottom is equipped with screen pack, and the top of the washing tank is equipped with feeding port, and lower part is equipped with liquid outlet.
5. the precious jade medicine compound broadleaf globethistle inflorescence tablet for the treatment of diabetes as described in claim 1, which is characterized in that the pharmacy can connect
The auxiliary material received is one or more in corn flour, calcium silicates, sodium carboxymethylcellulose, myristyl alcohol, fish glue, talcum.
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| "抑渴汤为主治疗糖尿病40例-附西药对照组38例";郭惠芳等;《辽宁中医杂志》;19960331;第23卷(第3期);第126-127页 * |
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Application publication date: 20151202 Assignee: GUANGXI HENGDERUN BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Assignor: GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS Contract record no.: X2023980045685 Denomination of invention: Yao medicine compound Zhugoufeng tablet for diabetes and its preparation method Granted publication date: 20181102 License type: Common License Record date: 20231106 |
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