CN106038926A - Traditional Chinese medicine for treating diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine for treating diabetes and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a traditional Chinese medicine for treating diabetes and a preparation method thereof, wherein the traditional Chinese medicine comprises the raw materials in parts by weight: 10-25 parts of walnut, 10-20 parts of Chinese yam, 5-25 parts of apple peel, 5-15 parts of tangerine peel, 5-20 parts of ginseng, 5-15 parts of semen cuscutae, 2-15 parts of Chinese wolfberry, and 5-10 parts of red dates. The preparation method comprises the steps: respectively crushing the walnut, Chinese yam, ginseng and semen cuscutae to obtain fine powder for standby application; adding water to the apple peel, tangerine peel, Chinese wolfberry and red dates, decocting, and concentrating a filtrate into an extract for standby application; and mixing the fine powder with the extract, pelleting, and sugar-coating to obtain the traditional Chinese medicine. The traditional Chinese medicine for treating diabetes has the advantages of good effect, short treatment course, and little toxic and side effects, and has the effects of promoting blood circulation and removing blood stasis, helping produce saliva and slake thirst, reducing hyperglycemia, and recovering pancreas islet functions; in addition, the traditional Chinese medicine has the advantages of easily obtained raw materials, low cost, and simple production method, and greatly reduces the economic pressure of diabetic patients.
Description
Technical field
The present invention relates to Chinese medicine preparation field, a kind of Chinese medicine treating diabetes and preparation method thereof.
Background technology
Diabetes are a kind of lifelong participation metabolic diseases being characterized with chronic hyperglycemia, are a kind of by inherited genetic factors and ring
Border factor interaction and the clinical syndrome that causes.In diabetics body, blood glucose constantly raises, and can cause various tissue, special
It not eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction, the serious harm health of people.At present to diabetes
Treatment mainly have oral drug therapy and insulin treatment, western medicine relies primarily on and reduces medicine sugar amount and keep on a diet
Method plays certain therapeutical effect, and unresolved this source of disease of reparation islet function, can not effectively control going out of complication
Existing；Insulin treatment is the most expensive, have side effect, and for a long time with producing antibody in vivo, makes therapeutic effect reduce；Mesh
Before also have the Chinese medicine of some treatment diabetes, but effect is not fully up to expectations.
Summary of the invention
It is an object of the invention to the deficiency for solving above-mentioned technical problem, it is provided that little the controlling of a kind of good effect, toxic and side effects
Treat Chinese medicine of diabetes and preparation method thereof.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine treating diabetes, according to the raw material of parts by weight be: Semen Juglandis 10-25 part, Rhizoma Dioscoreae 10-20 part, Pericarpium Mali pumilae
5-25 part, Pericarpium Citri Reticulatae 5-15 part, Radix Ginseng 5-20 part, Semen Cuscutae 5-15 part, Fructus Lycii 2-15 part, Fructus Jujubae 5-10 part.
As the further scheme of the present invention, the Chinese medicine of described treatment diabetes, according to the raw material of parts by weight it is: Semen Juglandis
20 parts, Rhizoma Dioscoreae 15 parts, Pericarpium Mali pumilae 18 parts, Pericarpium Citri Reticulatae 10 parts, Radix Ginseng 12 parts, Semen Cuscutae 11 parts, Fructus Lycii 12 parts, Fructus Jujubae 10 parts.
The preparation method of a kind of Chinese medicine treating diabetes, concretely comprises the following steps: (1) is by Semen Juglandis, Rhizoma Dioscoreae, Radix Ginseng, Semen Cuscutae
It is carried out-is dried-pulverize-cross 300 mesh sieves-weigh-mix respectively, obtain fine powder, standby；(2) by Pericarpium Mali pumilae, Pericarpium Citri Reticulatae, Chinese holly
Qi, Fructus Jujubae are together put in container, add 500-1000 part water, boil 1.5-2.5 hour, be filtrated to get filtrate I and filtering residue I；
(3) filtering residue I is put in container, add 200-500 part water, boil 0.5-1.5 hour, be filtrated to get filtrate II；(4) by filtrate
I merges with filtrate II, is concentrated into the extractum that relative density is 1.1-1.3, standby；(5) above-mentioned fine powder is mixed with extractum, system
Ball, sugar coating, obtain Chinese medicine.
As the further scheme of the present invention, Pericarpium Mali pumilae, Pericarpium Citri Reticulatae, Fructus Lycii, Fructus Jujubae are together put in container by step (2),
Add 700 parts of water, boil 2 hours, be filtrated to get filtrate I and filtering residue I.
As the further scheme of the present invention, filtering residue I is put in container by step (3), adds 300 parts of water, boils 1 little
Time, it is filtrated to get filtrate II.
As the further scheme of the present invention, filtrate I is merged by step (4) with filtrate II, and being concentrated into relative density is 1.2
Extractum, standby.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention obtains Chinese medicine according to the pharmacologic effect of the various medical material of Chinese medicine and pharmacy theory and combining, this Diabetes Mellitus Treated With Traditional Chinese Medicine effect
Good, short treating period, toxic and side effects are little, have blood circulation promoting and blood stasis dispelling, promoting the production of body fluid to quench thirst, reduction hyperglycemia, the curative effect of islet function recovered；Separately
Outward, this raw material of Chinese medicine is easy to get, low cost, manufacture method simple, greatly reduces the economic pressures of diabetics.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.
Embodiment 1
First Semen Juglandis 10 parts, Rhizoma Dioscoreae 10 parts, Pericarpium Mali pumilae 5 parts, Pericarpium Citri Reticulatae 5 parts, Radix Ginseng 5 parts, Semen Cuscutae 5 parts, Fructus Lycii 2 parts, red is weighed
Fructus Jujubae 5 parts；Wherein, Semen Juglandis, Rhizoma Dioscoreae, Radix Ginseng, Semen Cuscutae are carried out-are dried-pulverizes-cross 300 mesh sieves-weigh-mix respectively,
Obtain fine powder, standby；Pericarpium Mali pumilae, Pericarpium Citri Reticulatae, Fructus Lycii, Fructus Jujubae are together put in container, add 500 parts of water, boil 1.5 hours,
It is filtrated to get filtrate I and filtering residue I；Filtering residue I is put in container, adds 200 parts of water, boil 0.5 hour, be filtrated to get filtrate
Ⅱ；Filtrate I is merged with filtrate II, is concentrated into the extractum that relative density is 1.1, standby；Above-mentioned fine powder is mixed with extractum, system
Ball, sugar coating, obtain Chinese medicine.
Embodiment 2
First Semen Juglandis 25 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Mali pumilae 25 parts, Pericarpium Citri Reticulatae 15 parts, Radix Ginseng 20 parts, Semen Cuscutae 15 parts, Fructus Lycii 15 are weighed
Part, Fructus Jujubae 10 parts；Wherein, Semen Juglandis, Rhizoma Dioscoreae, Radix Ginseng, Semen Cuscutae are carried out respectively-are dried-pulverize-cross 300 mesh sieves-title
Weight-mixing, obtains fine powder, standby；Pericarpium Mali pumilae, Pericarpium Citri Reticulatae, Fructus Lycii, Fructus Jujubae are together put in container, adds 1000 parts of water, boil
2.5 hours, it is filtrated to get filtrate I and filtering residue I；Filtering residue I is put in container, adds 500 parts of water, boil 1.5 hours, filter
To filtrate II；Filtrate 1 is merged with filtrate II, is concentrated into the extractum that relative density is 1.3, standby；By above-mentioned fine powder and extractum
Mixing, pill, sugar coating, obtain Chinese medicine.
Embodiment 3
First Semen Juglandis 20 parts, Rhizoma Dioscoreae 15 parts, Pericarpium Mali pumilae 18 parts, Pericarpium Citri Reticulatae 10 parts, Radix Ginseng 12 parts, Semen Cuscutae 11 parts, Fructus Lycii 12 are weighed
Part, Fructus Jujubae 10 parts；Wherein, Semen Juglandis, Rhizoma Dioscoreae, Radix Ginseng, Semen Cuscutae are carried out respectively-are dried-pulverize-cross 300 mesh sieves-title
Weight-mixing, obtains fine powder, standby；Pericarpium Mali pumilae, Pericarpium Citri Reticulatae, Fructus Lycii, Fructus Jujubae are together put in container, adds 700 parts of water, boil 2
Hour, it is filtrated to get filtrate I and filtering residue I；Filtering residue I is put in container, adds 300 parts of water, boil 1 hour, be filtrated to get filter
Liquid II；Filtrate 1 is merged with filtrate II, is concentrated into the extractum that relative density is 1.2, standby；Above-mentioned fine powder is mixed with extractum,
Pill or sugar coating, obtain Chinese medicine.
With white mice pharmacological testing prove the present invention Chinese medicine have reduce blood sugar content curative effect:
Experimental animal: select male white mouse 280, body weight 18-25g, laboratory animal room of Medical University Of Anhui provide, modeling
Front first use normal feedstuff adaptability is fed 10 days, and normal feedstuff content is: protein 25%, carbohydrate 52%, lipase 37 %, its
He is 16% years old, and normal feedstuff is purchased from laboratory animal room of Medical University Of Anhui.
Experimental technique:
(1) experiment packet: 280 white mice are randomly divided into 4 groups, i.e. blank group, model group, treatment group, matched group, often organize 70
Only.
(2) Mouse Model makes: blank group continuation normal feedstuff is fed；Model group, treatment group and matched group are high
Heat forage feed, then (is dissolved in by injection streptozotocin (STZ) in the dosage disposable celiac of 20mg/kg body weight
0.1mmol/L citrate buffer solution, pH=4.4).The successful standard of modeling is: after 96 hours fasting 12 hours, by 2.5g/kg body
Heavily fill and feed 20%D-glucose solution, do oral glucose tolerance test, 0 and 120 minute blood glucose be respectively greater than 7.5mmol/L and
11.5mmol/L。
(3) medication:
Blank group: freely drink water, ingest；
Model group: after modeling success, freely drink water, ingest；
Treatment group: after modeling success, every day feeds with the Chinese medicine made by the embodiment of the present invention 3, three times on the one, once by adult
5 times of dosage are that 35g feeds；
Matched group: after modeling success, every day feeds with benzene sulphur hexamethylene urea glyburide medicine, three times on the one, once by adult human dose
5 times of nursings；
Experimental result:
Fasting 12 hours after 30 days, do oral glucose tolerance test, and experimental result is shown in Table 1.
Oral resistance to sugar result of the test respectively organized by table 1
Experiment conclusion:
As can be seen from Table 1, treatment group, compared with model group, can effectively reduce blood sugar content.
Clinical laboratory data:
1. the selection of patient: for showing the therapeutic effect of Chinese medicine of the present invention, in clinical trial, selects 220 diabeticss
As treatment group.Wherein 1 type 20 example, 11 type 200 examples；The maleest 150 examples, female 70 example；Wherein 15-25 year 7 examples, 26-35 year 15
Example, 36-55 year 85 examples, 56-70 year 113 examples.Select 220 examples and treatment group age, the state of an illness similar patient as compareing simultaneously
Group.
2. curative effect judgment criteria:
(1) effective
Diabetic symptom and complication disappear substantially, and hemorheology 5, fibrinolytic system 2 are improved, and fasting glucose is less than
110mg/dl, twenty-four-hour urine sugar relatively treats front drop-out value more than 50% less than 5g or blood sugar urinary sugar.
(2) effective
Diabetic symptom and complication substantially alleviate, hemorheology and 4 or 4 improvement derived above of fibrinolytic system, on an empty stomach
Blood glucose is less than 150mg/dl, and twenty-four-hour urine sugar relatively treats front drop-out value more than 30% less than 10g or blood sugar urinary sugar.
(3) invalid
Diabetic symptom and complication are not improved, even aggravation.
3. test method:
(1) treatment group patient disables other any medicines, the only oral Chinese medicine produced by the embodiment of the present invention 3, three times on the one, and one
Secondary 7g, takes after meal half an hour, within two months, is a course for the treatment of.
(2) matched group patient is administered orally benzene sulphur hexamethylene urea glyburide medicine, and the instructions of taking by specification of this medicine requires clothes
With, treatment group and matched group are all treated 2 months, check patient.
4. clinical trial results:
Before and after treatment group and matched group patient treatment, blood glucose, glucose in urine content are shown in Table 2, control treatment group 220 example diabetics
Treat statistical result and be shown in Table 3.
Blood glucose, glucose in urine content before and after table 2 treatment group and treatment of control group
Table 3 treatment by Chinese herbs statistical effect table
Experiment conclusion: the Chinese medicine of the present invention all has good therapeutic effect to the patient of different age group, the most not
Find toxic and side effects, and better than benzene sulphur hexamethylene urea glyburide curative effect of medication；For treating the total effective rate of diabetes it is
99.1%。
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment party
Formula, in the ken that one skilled in the relevant art is possessed, it is also possible on the premise of without departing from this patent objective
Make a variety of changes.
Claims (6)
1. the Chinese medicine treating diabetes, it is characterised in that be according to the raw material of parts by weight: Semen Juglandis 10-25 part, Rhizoma Dioscoreae
10-20 part, Pericarpium Mali pumilae 5-25 part, Pericarpium Citri Reticulatae 5-15 part, Radix Ginseng 5-20 part, Semen Cuscutae 5-15 part, Fructus Lycii 2-15 part, Fructus Jujubae 5-10
Part.
The Chinese medicine for the treatment of diabetes the most according to claim 1, it is characterised in that according to the raw material of parts by weight be: core
Fructus Persicae 20 parts, Rhizoma Dioscoreae 15 parts, Pericarpium Mali pumilae 18 parts, Pericarpium Citri Reticulatae 10 parts, Radix Ginseng 12 parts, Semen Cuscutae 11 parts, Fructus Lycii 12 parts, Fructus Jujubae 10 parts.
The preparation method of the Chinese medicine for the treatment of diabetes the most according to claim 1 and 2, it is characterised in that concretely comprise the following steps:
(1) Semen Juglandis, Rhizoma Dioscoreae, Radix Ginseng, Semen Cuscutae are carried out-are dried-pulverize-cross 300 mesh sieves-weigh-mix respectively, obtain thin
Powder, standby；(2) Pericarpium Mali pumilae, Pericarpium Citri Reticulatae, Fructus Lycii, Fructus Jujubae are together put in container, add 500-1000 part water, boil 1.5-2.5
Hour, it is filtrated to get filtrate I and filtering residue I；(3) filtering residue I is put in container, add 200-500 part water, boil 0.5-1.5 little
Time, it is filtrated to get filtrate II；(4) filtrate I is merged with filtrate II, be concentrated into the extractum that relative density is 1.1-1.3, standby；
(5) above-mentioned fine powder is mixed with extractum, pill, sugar coating, obtain Chinese medicine.
The preparation method of the Chinese medicine for the treatment of diabetes the most according to claim 3, it is characterised in that step (2) is by Fructus Mali pumilae
Skin, Pericarpium Citri Reticulatae, Fructus Lycii, Fructus Jujubae are together put in container, add 700 parts of water, boil 2 hours, are filtrated to get filtrate I and filtering residue I.
The preparation method of the Chinese medicine for the treatment of diabetes the most according to claim 3, it is characterised in that step (3) is by filtering residue I
Put in container, add 300 parts of water, boil 1 hour, be filtrated to get filtrate II.
The preparation method of the Chinese medicine for the treatment of diabetes the most according to claim 3, it is characterised in that step (4) is by filtrate I
Merge with filtrate II, be concentrated into the extractum that relative density is 1.2, standby.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108991199A (en) * | 2018-08-09 | 2018-12-14 | 兴义市黔农居养种植农民专业合作社 | A kind of the preparation method of ginger tea with brown sugar |
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