CN105327181A - Medicine composition for treating diabetes - Google Patents

Medicine composition for treating diabetes Download PDF

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Publication number
CN105327181A
CN105327181A CN201510871977.5A CN201510871977A CN105327181A CN 105327181 A CN105327181 A CN 105327181A CN 201510871977 A CN201510871977 A CN 201510871977A CN 105327181 A CN105327181 A CN 105327181A
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radix
pharmaceutical composition
diabetes
fructus
treatment
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庞大坤
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Jinan Xingyi Medical Technology Co Ltd
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Jinan Xingyi Medical Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention discloses a medicine composition for treating diabetes and a preparation method thereof. The medicine composition is prepared by matching ginseng, milkvetch roots, the fruit of Chinese magnoliavine, walnut kernels, the root of kudzu vine, rhizoma anemarrhenae, Chinese angelica, corn stigma, codonopsis pilosula, the fruit of Chinese wolfberry, black soya beans, sealwort, coptis chinensis, bitter gourd, dried tangerine or orange peel, the root of red-rooted salvia, the root of spinach, hawthorn fruits, hairyvein agrimony and the seed of Chinese dodder. The medicine composition can be made into drop pills and has the significant effect on treating diabetes.

Description

A kind of pharmaceutical composition for the treatment of diabetes
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of diabetes and preparation method thereof.
Background technology
In recent years, due to factors such as the change of growth in the living standard, dietary structure, the rhythm of life be becoming tight day and few dynamic life style of sitting more, whole world onset diabetes rate rapid development, diabetes have become the chronic disease of the third-largest serious threat human health after tumor, cardiovascular pathological changes.Current global diabetics is more than 1.2 hundred million people, and China patients occupies the second in the world, within 1994, just reaches 2,000 ten thousand.Estimate according to World Health Organization (WHO), by 2025, global maturity-onset diabetes patient numbers will increase to 300,000,000, and diabetes mellitus in China patient numbers will reach 4,000 ten thousand, and in future 50 years, diabetes will be Chinese serious public health problems.
The traditional Chinese medical science thinks that diabetes to be burnt cloudy losing by lung, stomach, the dirty heat of kidney three, water paddy transfer not normal caused by.Its base
This pathogenesis is cloudy body fluid deficiency consumption, scorching inclined Sheng, and deficiency of kidney-YIN is originally, and lung dryness of the stomach heat is mark, sick then cloudy damage QI consumed sun wound of a specified duration, and causes impairment of both QI and YIN, deficiency in both YIN and YANG, venation block, and the mistake of muscle arteries and veins is supported, and internal organs are impaired, gradually causes a series of double disease of appearance.The course of disease of diabetes is processes of deficiency of YIN affecting YANG.Dialectical with the moon, from gently to heavy, be then the conversion of the deficiency of YIN-deficiency of both QI and YIN-deficiency of both YIN and YANG.And venation block is through the overall process of primary disease and double disease.
In recent years, some scholars have inquired into the relation of TCM Syndrome Differentiation of Diabetes and clinical biochemistry indications.From changes such as islet function, blood lipid level, sexual hormones, corticoid level, immunologic function machine hemorheologys, the dependency that observation diabetes typing and above index change, find the ANOMALOUS VARIATIONS of various index, from gently to heavy, how with the deficiency of YIN-deficiency of both QI and YIN-deficiency of both YIN and YANG future development.Embody the material base that diabetes typing is inquired in the combination of Chinese and Western medicine.
Although the research and development of Remedies for diabetes achieve larger progress, but still there is many deficiencies.Therefore, in order to provide more safe and effective medicine to diabetics, the research and development of this type of medicine and rationally application are still the severe problems of in face of vast researcher and medical personnel one of pendulum.Present most of diabetics to have Western medicine and the method such as insulin injection is treated, although these medicines have certain curative effect, but still can not be satisfactory.Up to the present, a kind of specific medicament thoroughly curing various diabetes is not also found.
Radix Ginseng: this product is the dry root of Araliaceae Radix Ginseng PanaxginsengC.A.Mey..[nature and flavor] sweet, micro-hardship, flat.[return through] returns spleen, lung, heart channel.[function cures mainly] strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.
The Radix Astragali: this product is leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) dry root of Bge..Spring, Qiu Erji excavate, and removing fibrous root and root head, dry.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Fructus Schisandrae Chinensis: this product is magnoliaceae schisandra Schisandrachinensis(Turcz.) dry mature fruit of Baill..[meridian distribution of property and flavor]: temperature; Sour, sweet; Return lung, the heart, kidney channel, [function with cure mainly] restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Semen Juglandis: this product is the dry mature seed of juglandaceae plant Semen Juglandis JuglansregiaL..Gather during fruit maturation in autumn, removing meat peel, dries, then removes nucleocapsid and wooden barrier film.Nature and flavor are sweet, temperature.Return kidney, lung, large intestine channel.[function with cure mainly] tonifying the kidney to consolidate the essence, warming the lung Dingchuan, loosening bowel to relieve constipation.Be applicable to the diseases such as cough, lumbago, sexual impotence, seminal emission, constipation due to dry stool, stranguria caused by urinary stone of suffering from a deficiency of the kidney.
Radix Puerariae: this product is leguminous plant herba Gelsemii Elegantispuerarialobata(Willd.) drying of Ohwi root.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter; Dry.[nature and flavor] Gan Xin is flat.[return through] enters spleen, stomach warp, [function cures mainly] yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, and relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.
The Rhizoma Anemarrhenae: this product is the dry rhizome of liliaceous plant Rhizoma Anemarrhenae AnemarrhenaasphodeloidesBunge..Spring, Qiu Erji excavate, and removing fibrous root and silt, dry, and practise and claim " RHIZOMA ANEMARRHENAE with peet "; Or removing crust, dry.[meridian distribution of property and flavor] is bitter, sweet, cold.Return lung, stomach, kidney channel.[function cures mainly] clearing away heat-fire--external treatment fever caused by exogenous pathogenic factors, high hot excessive thirst, treatment by oral administration of medicines cough due to lung-heat, gastric heat is quenched one's thirst.Promote the production of body fluid and moisturize--xeropulmonary cough; Dryness of the intestine constipation; Osteopyrexia and fever.
Radix Angelicae Sinensis: this product is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.[nature and flavor] sweet in the mouth, pungent, bitter, warm in nature.[return through] returns liver, the heart, spleen channel.[effect classification] hematonic, emmenagogue, analgesic.[effect] enriches blood, and invigorates blood circulation, and menstruction regulating and pain relieving moisturizes laxation.The all cards of [curing mainly] blood deficiency, dysmenorrhea, lump in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down.
Stigma Maydis: be grass family Zea plant semen MaydiszeamaysL. stylewith fresh idea.Gather during harvesting corn in autumn, dry or dry.[nature and flavor] are sweet, flat.[return through] returns bladder, liver, gallbladder meridian.[function cures mainly] diuresis, expels the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting.Control oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, acute mastitis.
Radix Codonopsis: this product is Campanulaceae Radix Codonopsis Codonopsispilosula(Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) CodonopsispilosulaNannf.var.modesta(Nannf.) dry root of L.T.Shen or radix codonpsis tangshen CodonopsistangshenOliv..Autumn excavates, and cleans, dries.[meridian distribution of property and flavor] is bitter, is slightly cold.Return liver, gallbladder meridian.[function cures mainly] reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum LyciumbarbarumL..Summer, autumn two gather when season, fruit took on a red color, hot-air seasoning, removing carpopodium.Or dry in the air to rhicnosis, dry, removing carpopodium.[nature and flavor]: sweet in the mouth; Property is put down.[return through]: return Liver Channel; Kidney channel; Lung meridian.[function]: nourishing the liver; Nourishing kidney; Lung moistening.[curing mainly] caused by liver and kidney deficiency; Have a dizzy spell; Visual unclear; Soreness of the waist and knees; Impotence and seminal emission; Cough due to consumptive disease; To quench one's thirst taking fluids profusely.
Semen sojae atricolor: be legume soybean Glycinemax(L.) black seeds of Merr. [PhaseolusmaxL.].[nature and flavor] are sweet, flat.[return through] enters spleen, kidney channel.[function] blood-enriching face-nourishing, black hair, tranquilizing by nourishing the heart.Semen sojae atricolor has the effect such as nourishing the liver and kidney, blood circulation promoting and enriching, rich flesh skin care, and clothes can make skin become tenderly white bright and clean for a long time, benefiting essence-blood.[curing mainly] is thanks to cloudy for suffering from a deficiency of the kidney, polydipsia of quenching one's thirst, frequent micturition; The hepatic and renal YIN deficiency, has a dizzy spell, poor vision, or early whitening of beard and hair; Beriberi edema, or arthralgia chiefly caused by damp pathogen contracture, lumbago; In abdomen, contraction is anxious has a pain or dysentery stomachache.
Rhizoma Polygonati: this product is the dry rhizome of liliaceous plant P. kingianum PolygonatumkingianumColl.etHemsl..Spring, Qiu Erji excavate, and removing fibrous root, cleans, and put in boiling water and slightly scald or steam to the saturating heart, dry.[nature and flavor]: property is put down, sweet in the mouth.[return through]: enter spleen, lung, kidney channel.[function cures mainly] nourishing YIN and moistening the lung; Invigorating the spleen and replenishing QI, Zishen fill fine.Main deficiency of YIN chronic cough; Xeropulmonary cough; Insufficiency of the spleen weak; Lack of appetite xerostomia; Quench one's thirst; Deficiency of the kidney soreness of the waist and knees; Impotence and seminal emission; Tinnitus order is dark; Early whitening of beard and hair; Body void is won thin; Wind favus disease.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Rhizoma Coptidis: be the dry rhizome of cohosh Rhizoma Coptidis (CoptischinensisFranch.), Coptis deltoidea C.Y.Cheng et Hsiao (CoptisdeltoideaC.Y.ChengetHsiao) and Coptis Teeta Wall (CoptisteetaWall.).Autumn excavates, removing fibrous root and silt, dry, hits residual fibrous root.[meridian distribution of property and flavor] (root) is bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Fructus Momordicae charantiae: Cucurbitaceae Momordica plant Fructus Momordicae charantiae MomordicacharantiaL., is used as medicine with melon, root, rattan and leaf.Summer gathers, and processes respectively, dries.[nature and flavor] bitter in the mouth; Cold in nature.[return through] GUIXIN; Spleen; Lung meridian.[function cures mainly] clearing away summer-heat washs heat; Improving eyesight; Removing toxic substances.Main summer-heat excessive thirst; Quench one's thirst; Acute conjunctivitis pain; Dysentery; Sore and toxic.
Pericarpium Citri Reticulatae: this product is the dry mature skin of rutaceae orange CitrusreticulataBlanco and variety thereof.[nature and flavor]: warm in nature, acrid in the mouth, bitter in the mouth.[return through]: enter spleen channel, stomach through, lung meridian.[attending effectiveness]: regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Radix Salviae Miltiorrhizae: be the dry root welding technology of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Spring, Qiu Erji excavate, removing silt, dry.Whole nation most area has distribution.[nature and flavor] are bitter, are slightly cold.[return through] enters the heart, Liver Channel.[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix spinach: this product is the root of Chenopodiaceae Herba Spinaciae SpinaciaoleraceaL..[nature and flavor] are sweet; Property is put down.[return through] liver; Stomach; Large intestine; Small intestine meridian.[function cures mainly] nourishes blood; Hemostasis; Suppressing the hyperactive liver; Moisturize.Main epistaxis; Have blood in stool; Headache; Dizzy; Conjunctival congestion; Nyctalopia; To quench one's thirst taking fluids profusely; Just close; Hemorrhoid.
Fructus Crataegi: this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae CrataeguspinnatifidaBge.var.majorN.E.Br. or Fructus Crataegi CrataeguspinnatifidaBge..Gather during fruit maturation in autumn, section, dry.[meridian distribution of property and flavor] sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.[function cures mainly] appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.
Herba Agrimoniae: this product is the dry aerial parts of rosaceous plant Radix Agrimoniae AgrimoniapilosaLedeb..Summer, autumn two tap when season, stem and leaf was luxuriant, removing impurity, dry.[nature and flavor] are bitter, puckery, flat.[return through] GUIXIN, Liver Channel.[function cures mainly] astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Semen Cuscutae: this product is convolvulaceous plant semen CuscutaecuscutachinensisLam. drying mature seed.To gather during fruit maturation in autumn plant, dry, lay seed, removing impurity.[nature and flavor]: Xin Gan, flat.[return through] enters liver, kidney channel.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective treatment diabetes and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Treat a pharmaceutical composition for diabetes, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Radix Ginseng 10-15g Radix Astragali 40-50g Fructus Schisandrae Chinensis 20-30g Semen Juglandis 20-30g Radix Puerariae 30-40g Rhizoma Anemarrhenae 10-15g Radix Angelicae Sinensis 10-15g Stigma Maydis 70-80g Radix Codonopsis 10-15g Fructus Lycii 10-15g Semen sojae atricolor 40-50g Rhizoma Polygonati 30-40g Rhizoma Coptidis 10-15g Fructus Momordicae charantiae 40-50g Pericarpium Citri Reticulatae 20-30g Radix Salviae Miltiorrhizae 10-15g Radix spinach 50-60g Fructus Crataegi 10-15g Herba Agrimoniae 40-50g Semen Cuscutae 40-50g.
Preferably treat a pharmaceutical composition for diabetes, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Radix Ginseng 10g Radix Astragali 40g Fructus Schisandrae Chinensis 30g Semen Juglandis 20g Radix Puerariae 30g Rhizoma Anemarrhenae 10g Radix Angelicae Sinensis 10g Stigma Maydis 80g Radix Codonopsis 10g Fructus Lycii 10g Semen sojae atricolor 50g Rhizoma Polygonati 30g Rhizoma Coptidis 15g Fructus Momordicae charantiae 50g Pericarpium Citri Reticulatae 20g Radix Salviae Miltiorrhizae 10g Radix spinach 60g Fructus Crataegi 10g Herba Agrimoniae 40g Semen Cuscutae 40g.
Treat a pharmaceutical composition for diabetes, it is characterized in that this pharmaceutical composition can adopt pharmaceutics conventional method to make drop pill.
Treat a pharmaceutical composition for diabetes, it is characterized in that described diabetes specifically refer to type 1 diabetes and type 2 diabetes mellitus.
Pharmaceutical composition has good therapeutic effect in treatment diabetes, can diabetes-alleviating patients symptomatic, reduces blood sugar level.
embodiment and experimental example
Embodiment 1: a kind of pharmaceutical composition for the treatment of diabetes and preparation method thereof:
The composition of crude drug and weight portion are: Radix Ginseng 10g Radix Astragali 40g Fructus Schisandrae Chinensis 30g Semen Juglandis 20g Radix Puerariae 30g Rhizoma Anemarrhenae 10g Radix Angelicae Sinensis 10g Stigma Maydis 80g Radix Codonopsis 10g Fructus Lycii 10g Semen sojae atricolor 50g Rhizoma Polygonati 30g Rhizoma Coptidis 15g Fructus Momordicae charantiae 50g Pericarpium Citri Reticulatae 20g Radix Salviae Miltiorrhizae 10g Radix spinach 60g Fructus Crataegi 10g Herba Agrimoniae 40g Semen Cuscutae 40g;
Preparation method: get Radix Ginseng 10g by crude drug proportioning, Radix Astragali 40g, Fructus Schisandrae Chinensis 30g, Semen Juglandis 20g, Radix Puerariae 30g, Rhizoma Anemarrhenae 10g, Radix Angelicae Sinensis 10g, Stigma Maydis 80g, Radix Codonopsis 10g, Fructus Lycii 10g, Semen sojae atricolor 50g, Rhizoma Polygonati 30g, Rhizoma Coptidis 15g, Fructus Momordicae charantiae 50g, Pericarpium Citri Reticulatae 20g, Radix Salviae Miltiorrhizae 10g, Radix spinach 60g, Fructus Crataegi 10g, Herba Agrimoniae 40g, Semen Cuscutae 40g, mixing, with weight percent concentration 45% ethanol as solvent, extract at 25 DEG C of warm macerating, extraction time is 20 times, each extraction time is 5 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by LS-300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS-300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition,
The preparation of medicament composition dropping pills: take polyethylene glycol 6000 150g water-bath (80 DEG C) heating and boil molten, add pharmaceutical composition 15g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 3 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2cm apart from liquid level, drips speed with per minute 60 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 2: a kind of pharmaceutical composition for the treatment of diabetes and preparation method thereof
The composition of crude drug and weight portion are: Radix Ginseng 10g Radix Astragali 50g Fructus Schisandrae Chinensis 20g Semen Juglandis 30g Radix Puerariae 30g Rhizoma Anemarrhenae 15g Radix Angelicae Sinensis 10g Stigma Maydis 80g Radix Codonopsis 10g Fructus Lycii 15g Semen sojae atricolor 40g Rhizoma Polygonati 40g Rhizoma Coptidis 10g Fructus Momordicae charantiae 50g Pericarpium Citri Reticulatae 20g Radix Salviae Miltiorrhizae 15g Radix spinach 50g Fructus Crataegi 15g Herba Agrimoniae 40g Semen Cuscutae 50g;
Preparation method: get Radix Ginseng 10g by crude drug proportioning, Radix Astragali 50g, Fructus Schisandrae Chinensis 20g, Semen Juglandis 30g, Radix Puerariae 30g, Rhizoma Anemarrhenae 15g, Radix Angelicae Sinensis 10g, Stigma Maydis 80g, Radix Codonopsis 10g, Fructus Lycii 15g, Semen sojae atricolor 40g, Rhizoma Polygonati 40g, Rhizoma Coptidis 10g, Fructus Momordicae charantiae 50g, Pericarpium Citri Reticulatae 20g, Radix Salviae Miltiorrhizae 15g, Radix spinach 50g, Fructus Crataegi 15g, Herba Agrimoniae 40g, Semen Cuscutae 50g, mixing, with weight percent concentration 45% ethanol as solvent, extract at 25 DEG C of warm macerating, extraction time is 20 times, each extraction time is 5 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by LS-300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS-300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition,
The preparation of medicament composition dropping pills: take polyethylene glycol 6000 150g water-bath (80 DEG C) heating and boil molten, add pharmaceutical composition 15g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 3 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2cm apart from liquid level, drips speed with per minute 60 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 2: a kind of pharmaceutical composition for the treatment of diabetes and preparation method thereof
The composition of crude drug and weight portion are: Radix Ginseng 15g Radix Astragali 40g Fructus Schisandrae Chinensis 30g Semen Juglandis 20g Radix Puerariae 40g Rhizoma Anemarrhenae 10g Radix Angelicae Sinensis 15g Stigma Maydis 70g Radix Codonopsis 15g Fructus Lycii 10g Semen sojae atricolor 50g Rhizoma Polygonati 30g Rhizoma Coptidis 15g Fructus Momordicae charantiae 40g Pericarpium Citri Reticulatae 30g Radix Salviae Miltiorrhizae 10g Radix spinach 60g Fructus Crataegi 10g Herba Agrimoniae 50g Semen Cuscutae 40g;
Preparation method: get Radix Ginseng 15g by crude drug proportioning, Radix Astragali 40g, Fructus Schisandrae Chinensis 30g, Semen Juglandis 20g, Radix Puerariae 40g, Rhizoma Anemarrhenae 10g, Radix Angelicae Sinensis 15g, Stigma Maydis 70g, Radix Codonopsis 15g, Fructus Lycii 10g, Semen sojae atricolor 50g, Rhizoma Polygonati 30g, Rhizoma Coptidis 15g, Fructus Momordicae charantiae 40g, Pericarpium Citri Reticulatae 30g, Radix Salviae Miltiorrhizae 10g, Radix spinach 60g, Fructus Crataegi 10g, Herba Agrimoniae 50g, Semen Cuscutae 40g, mixing, with weight percent concentration 45% ethanol as solvent, extract at 25 DEG C of warm macerating, extraction time is 20 times, each extraction time is 5 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by LS-300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS-300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition,
The preparation of medicament composition dropping pills: take polyethylene glycol 6000 150g water-bath (80 DEG C) heating and boil molten, add pharmaceutical composition 15g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 3 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2cm apart from liquid level, drips speed with per minute 60 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Experimental example 1: treatment diabetes experimental study
1 data and method
1.1 physical data
Choose the patient that in January, 2012 ~ 2,013 38 examples that hospital accepts for medical treatment year January are diagnosed as type 2 diabetes mellitus on inspection, the age is 31 ~ 76 years old.Be divided into two groups at random, treatment group 19 example, man 9 example, female 10 example, the mean age be (44.5 ± 6.2) year, the course of disease is 2 ~ 10 years; Matched group 19 example, man 10 example, female 9 example, the mean age be (45.1 ± 6.1) year, the course of disease is 2.4 ~ 10 years.The aspect such as age, sex, the course of disease of two groups of patients compares, and no significant difference (P > 0.05), has comparability.
1.2 inclusive criteria
1. all patients are diagnosed as type 2 diabetes mellitus all on inspection; 2. after Chinese medical discrimination, meet the standard of type of deficiency of both QI and YIN; 3. through patient's informed consent, signature Informed Consent Form, follows the doctor's advice and takes medicine according to quantity on time.
1.3 Therapeutic Method
Matched group adopts conventional western medicine to treat, and treatment group adds pharmaceutical composition treatment on the basis of matched group, and two groups of patients all give diabetic diet and instruct, and carry out regular diet control, medication treats two months.
Matched group: oral gliclazid in tablets 80mg, 1 time/d, metformin hydrochloride tablet 0.5g, 3 times/d.
Treatment group: on the medication basis for the treatment of of control group, gives embodiment 1 pharmaceutical composition (lot number 20110923), point 2 sub-services sooner or later, each 1.5g.
1.4 criterion of therapeutical effect
With patient clinical sings and symptoms be improved significantly, and detect fasting glucose and 2h-plasma glucose and be down in normal range as effective; All be improved with patient clinical sings and symptoms, before detection fasting glucose and 2h-plasma glucose decrease beyond treatment 20% is effective; With patient clinical sings and symptoms without improving or increasing the weight of, it is invalid that detection fasting glucose and 2h-plasma glucose decline not obvious.
1.5 statistical method
All data acquisition SPSS16.0 carry out statistical procedures, and measurement data adopts t inspection, and enumeration data adopts inspection, and P < 0.05 has statistical significance for difference.
2 results
2.1 Clinical efficacy comparison
Treatment group total effective rate is 94.74%, and matched group total effective rate is that 68.42%, two groups of comparitive study differences have statistical significance (P < 0.05), refers to table 1.
Table 1 Clinical efficacy comparison (example)
Group Number of cases Effective Effectively Invalid Total effective rate (%)
Treatment group 19 11 7 1 94.74 1)
Matched group 19 8 5 6 68.42
Note: 1)p < 0.05, two groups of comparitive study obvious differences, have statistical significance.
After 2.2 treatments, the blood sugar level of two groups of patients all declines, and treatment group fall is higher than matched group, and through comparing, difference has statistical significance (P < 0.05), specifically in table 2.
The comparison (x ± s) of fasting blood glucose level before and after table 2 liang group patient treatment
Group Before treatment (mmol/L) After treatment (mmol/L) 1)
Treatment group 12.08±2.22 6. 25±1.57 2)
Matched group 12.06±2.19 7. 78±1.63 3)
Note: 1)after P < 0.05, two groups treatment, blood sugar level comparing difference has statistical significance; 2)p < 0.05, treatment group treatment Patients Before And After blood sugar level comparing difference has statistical significance; 3)p < 0.05, treatment of control group Patients Before And After blood sugar level comparing difference has statistical significance.
Result shows: pharmaceutical composition has good therapeutic effect in treatment diabetes, can diabetes-alleviating patients symptomatic, reduces blood sugar level, is clinically worthy to be popularized.

Claims (4)

1. treat a pharmaceutical composition for diabetes, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Radix Ginseng 10-15g Radix Astragali 40-50g Fructus Schisandrae Chinensis 20-30g Semen Juglandis 20-30g Radix Puerariae 30-40g Rhizoma Anemarrhenae 10-15g Radix Angelicae Sinensis 10-15g Stigma Maydis 70-80g Radix Codonopsis 10-15g Fructus Lycii 10-15g Semen sojae atricolor 40-50g Rhizoma Polygonati 30-40g Rhizoma Coptidis 10-15g Fructus Momordicae charantiae 40-50g Pericarpium Citri Reticulatae 20-30g Radix Salviae Miltiorrhizae 10-15g Radix spinach 50-60g Fructus Crataegi 10-15g Herba Agrimoniae 40-50g Semen Cuscutae 40-50g.
2. a kind of pharmaceutical composition for the treatment of diabetes according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Radix Ginseng 10g Radix Astragali 40g Fructus Schisandrae Chinensis 30g Semen Juglandis 20g Radix Puerariae 30g Rhizoma Anemarrhenae 10g Radix Angelicae Sinensis 10g Stigma Maydis 80g Radix Codonopsis 10g Fructus Lycii 10g Semen sojae atricolor 50g Rhizoma Polygonati 30g Rhizoma Coptidis 15g Fructus Momordicae charantiae 50g Pericarpium Citri Reticulatae 20g Radix Salviae Miltiorrhizae 10g Radix spinach 60g Fructus Crataegi 10g Herba Agrimoniae 40g Semen Cuscutae 40g.
3. a kind of pharmaceutical composition for the treatment of diabetes according to claim 1, is characterized in that this pharmaceutical composition can adopt pharmaceutics conventional method to make drop pill.
4. a kind of pharmaceutical composition for the treatment of diabetes according to claim 1, is characterized in that described diabetes specifically refer to type 2 diabetes mellitus.
CN201510871977.5A 2015-12-03 2015-12-03 Medicine composition for treating diabetes Withdrawn CN105327181A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106038926A (en) * 2016-08-16 2016-10-26 汪培杰 Traditional Chinese medicine for treating diabetes and preparation method thereof
CN106177659A (en) * 2016-07-14 2016-12-07 郑州五行舒体商贸有限公司 Vigor draft liquid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106177659A (en) * 2016-07-14 2016-12-07 郑州五行舒体商贸有限公司 Vigor draft liquid
CN106038926A (en) * 2016-08-16 2016-10-26 汪培杰 Traditional Chinese medicine for treating diabetes and preparation method thereof

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Application publication date: 20160217