CN106728835B - A kind of Chinese medicine for treating diabetes - Google Patents
A kind of Chinese medicine for treating diabetes Download PDFInfo
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- CN106728835B CN106728835B CN201611226204.2A CN201611226204A CN106728835B CN 106728835 B CN106728835 B CN 106728835B CN 201611226204 A CN201611226204 A CN 201611226204A CN 106728835 B CN106728835 B CN 106728835B
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Abstract
The invention discloses a kind of Chinese medicine for treating diabetes and preparation method thereof, the Chinese medicine is by weight meter：5 15 grams of the red sage root, 3 10 grams of safflower, the dried rhizome of rehmannia, each 15 25 grams of Chinese yam；Each 5 15 grams of the fruit of Chinese magnoliavine, the root of kudzu vine；Each 10 15 grams of clam meal, bryozoatum；10 20 grams of root of Chinese trichosanthes, 37 grams of the membrane of a chicken's gizzard, watermelon peel, each 10 20 grams of waxgourd peel, 50 70 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 5 15 grams of Radix Codonopsis, 10 15 grams of compositions of 25 35 grams of gypsum and radix scrophulariae.The present invention makes full use of Chinese prescription theoretical, acted in concert with each other between medicine, promoting blood circulation and removing blood stasis, kidney water rises internal heat drop, and the division of labor is clear and definite, primary and secondary protrudes, complement each other and accompanying symptoms is taken into account while main symptom is treated, treatment is comprehensive, curative for effect, by clinical verification significant effect, can long-term use to diabetes and as caused by diabetes other uncomfortable have significant curative effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, particularly a kind of Chinese medicine for treating diabetes.
Background technology
Diabetes be one group caused by defect of insulin secretion and/or insulin action obstacle characterized by hyperglycaemia
Metabolic disease.Persistent high blood sugar and long-term metabolic disorder etc. can cause body tissue's organ, particularly eye, kidney, angiocarpy
And the infringement of nervous system and its dysfunction and exhaustion.Severe patient can cause dehydration, electrolyte disturbance and acid-base imbalance
Deng acute complicationses DKA and Hyperosmotic coma.
Oral drugs are mainly used in treating DM2, and for DM2 patient, itself pancreas function has been damaged, and medicine is again
B cell excreting insulin is stimulated into pancreatic cell, is so worked overloadingly, can only accelerate the exhaustion of B cells of pancreas, finally lead
Cause drug therapy failure.In addition, Drug absorbability also prevents the suction of nutriment while intestinal wall prevents glucose absorption
Receive, this will result directly in patient's malnutrition, immunity of organisms declines, and be more easy to concurrent Other diseases.Because oral drugs can only
DM2 postprandial blood sugar is controlled, effect is not had completely to the glycemic control of other periods, it is impossible to by 24 hours glycemic controls of whole day
Steadily, so the generation of complication can not be prevented or delayed.Especially first hair style DM2 patient, if initially selecting mouth
Drug therapy is taken, not only glycemic control is bad, also loses optimal therapic opportunity.Most of this kind of DM2 patient takes for a long time
During medicine, not only the disease of itself is not effectively controlled, and also results in liver and kidney is irreversibly injured, then suffer from
Soon, they cannot be as the life normal person for disease.
The drawbacks of multiple subcutaneous injections insulin therapy, daily 2-5 timing are subcutaneously injected, it is impossible to fully meet DM
The physiological requirements of patient itself, uncertain insulin requirements amount is unable to cope with, unplanned events can not also be handled a situation with ease；
After a large amount of insulin of a shot, " washing basin " easily is formed subcutaneous, it is non-constant that absorption of insulin enters blood speed, causes blood
The larger fluctuation of sugar, it is impossible to which 24 hours glycemic controls of whole day is steady；(3) constant absorption of insulin can not be blocked or reduce,
Once generation hypoglycemia, just must additionally it feed, it is unfavorable to glycemic control；Hypoglycemic speed is slower, and insulin dosage is big, easily sends out
The outer hypoglycemia of business；Injection daily, patient is very painful, also very inconvenient, can not improve the quality of living.
China's medical science is early in B.C. twoth century《The Yellow Emperor's Canon of Internal Medicine》With regard to discussion " category " diabetes category about diabetes, disappear
The meaning of thirsty sick polydipsia of becoming thin.The pathogenesis of diabete, scorching for main pathogenesis with the deficiency of Yin, the deficiency of Yin is this, scorching to mark, two
Person's reciprocal causation, in whole pathological process.
Eastern Han Dynasty's last years of a dynasty or reign, famous traditional Chinese medical science scholar Zhang Zhongjing write《Synopsis Golden Chamber》One book neutrality is quenched one's thirst a special piece, it is proposed that stomach energy, kidney
The etiology and pathogenesis empty, lung stomach Tianjin wound is diabete.
Song Dynasty Zhao Ji writes《General Records of Holy Universal Relief》There is saying for " three disappearing " the middle beginning, proposes diabete：" it is former its then one, push away it and indicate
Three：One says and quenches one's thirst, and with thirsty and unfavorable, draws for drink is exaggerated it；During two say and disappear, disappear speech with not thirsty and sharp, in hot gas；Three say kidney
Disappear, the multiple profit with thirsty, kidney is dry can not to be made to be brief, and this is not cured long, can be the disease of oedema ulcer ".
Jin and Yuan dynasty ZHU Dan-xi explicitly point out three disappear and refer to position for." above do not disappear person, the person of disappearing in lung ..., stomach
... under the person of disappearing, kidney ... " treatment of emphasizing to quench one's thirst should be based on " yin-nourishing, fall fire, green blood ", wound drinks nourishing Yin and promoting production of body fluid with lotus root juice
Treatment is quenched one's thirst.
Liu's interchannel《Three disappear opinion》Cloud：" therefore the person of quenching one's thirst is controlled, the void of kidney tonifying water cold sensation of the genitalia, and purge the sthenic heart-fire sun heat is real, except stomach is dry
Heat very, body fluid declines in the body that helps, and road is dissipated without tying, and body fluid life is without withered, and qi and blood profit is without puckery, then sick day has been.”
《Medicine Comprehended three=disappear a piece》Point out：" control the person of disappearing, its lung of Yi Run, and its clear stomach, two winter soup masters it；In controlling
The person of disappearing, its preferably clear stomach, and grow its kidney, dried rhizome of rehmannia decoction of Eight Ingredients master it；The person of disappearing is controled the inferior, preferably grows its kidney, and mends its lung, Dihuang Decoction, raw arteries and veins
Dissipate and lead it.Disappear clearing stomach person on husband, stomach fire is hindered lung；In disappear nourshing kidney person, phase fire is attacked stomach；Under disappear clearing lung-heat
Person, source is with unboiled water in taste.Three disappear control, it is not necessary to specially hold this warp, and grow its change source, then disease easily fully recover from an illness.”
Diabetes spp " is quenched one's thirst " category in the traditional Chinese medical science, ancient Chinese medicine doctor more more than disappear, in disappear, under disappear " three disappear " argument, controlled by it
Method, above disappear clearing away the lungheat and moisturizing, in disappear eliminating stomach-fire, under disappear nourshing kidney fall fire, example is well-established law.Zhao Xianke《Thorough Knowledge of Medicine》Middle promotion " is controlled and disappears it
Method, without upper, middle and lower are divided, kidney is controlled in the ban as suddenly ", oppose that abuse bitter cold gram is cut down.
The content of the invention
Long-term taking medicine is needed for existing western medical treatment diabetes, and blood glucose is easily repeatedly, treats halfway problem,
It is an object of the invention to provide a kind of Chinese medicine preparation for treating diabetes, to quench one's thirst to be basic, diabetes are effectively treated.
The technical scheme that the present invention solves above-mentioned technical problem is,
A kind of Chinese medicine for treating diabetes, by weight meter：5-15 grams of the red sage root, 3-10 grams of safflower, the dried rhizome of rehmannia, each 15- of Chinese yam
25 grams；Each 5-15 grams of the fruit of Chinese magnoliavine, the root of kudzu vine；Each 10-15 grams of clam meal, bryozoatum；10-20 grams of root of Chinese trichosanthes, 3-7 grams of the membrane of a chicken's gizzard, watermelon
Each 10-20 grams of skin, waxgourd peel, 50-70 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 5-15 grams of Radix Codonopsis, 25-35 grams of gypsum and radix scrophulariae
10-15 grams of composition.
Preferably, a kind of Chinese medicine for treating diabetes, by weight meter：8-10 grams of the red sage root, 5-8 grams of safflower, the dried rhizome of rehmannia, Chinese yam
Each 18-22 grams；Each 8-12 grams of the fruit of Chinese magnoliavine, the root of kudzu vine；Each 12-14 grams of clam meal, bryozoatum；13-18 grams of root of Chinese trichosanthes, 4-6 grams of the membrane of a chicken's gizzard,
Each 12-18 grams of watermelon peel, waxgourd peel, 55-65 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 8-12 grams of Radix Codonopsis, 28-32 grams of gypsum and member
12-14 grams of composition of ginseng.
Preferably, a kind of Chinese medicine for treating diabetes, by weight meter：10 grams of the red sage root, 6 grams of safflower, the dried rhizome of rehmannia, Chinese yam each 20
Gram；Each 10 grams of the fruit of Chinese magnoliavine, the root of kudzu vine；Each 12 grams of clam meal, bryozoatum；15 grams of root of Chinese trichosanthes, 5 grams of the membrane of a chicken's gizzard, watermelon peel, waxgourd peel each 15
Gram, 60 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 10 grams of Radix Codonopsis, 12 grams of compositions of 30 grams of gypsum and radix scrophulariae.
In said components,
Safflower
The logical stasis of blood class Chinese medicine of promoting blood circulation
Meridian distribution of property and flavor：It is pungent, warm.The thoughts of returning home, Liver Channel.
Effect：It is promoting blood circulation and removing blood stasis, stimulate the menstrual flow.
Cure mainly：For amenorrhea due to stagnation of blood, postpartum stasis , Disorder lumps in the abdomen stagnate, injuries from falls as well, measles without adequate eruption.
The red sage root
Blood circulation promoting nourishes blood class Chinese medicine
Meridian distribution of property and flavor：Hardship, it is slightly cold.The thoughts of returning home, pericardium, Liver Channel.
Effect：Promoting blood circulation, cool blood to disappear carbuncle, nourishing blood and tranquilization.
Cure mainly：It is insomnia for irregular menstruation, trusted subordinate's pain , lumps in the chest and abdomen, beriberoid pyretic arthralgia, sore swell and ache curative, agitation, palpitaition,
Insomnia.
Radix rehmanniae recen
Clearing heat and cooling blood class Chinese medicine
Meridian distribution of property and flavor：It is sweet, bitter, tremble with fear.The thoughts of returning home, liver and kidney channel.
Effect：Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid.
Cure mainly：For Vexed, tongue is deep red, blood-head tells nosebleed, atropurpureus macula, consumption of YIN caused by febrile disease, drink of quenching one's thirst more.
Chinese yam
Tonifying Qi class Chinese medicine
Meridian distribution of property and flavor：It is sweet, put down.Returns spleen, lung, kidney channel.
Effect：Supplementing qi and nourishing yin, help spleen and lung, invigorates the kidney and stops nocturnal emission.
Cure mainly：Quenched one's thirst for spleen eating less, diarrhea with loose stool, deficiency syndrome of the lung cough and asthma, frequent micturition of passing out semen, the deficiency of Yin.
The fruit of Chinese magnoliavine
Astringentses Chinese medicine
Meridian distribution of property and flavor：Acid, temperature.Return lung, kidney, the heart channel of Hang-Shaoyin.
Effect：Astringe the lung nourshing kidney, promote the production of body fluid arrest sweating, puckery smart antidiarrheal, antitoxic heart-soothing and sedative.
Cure mainly：Rushed down for chronic cough and dyspnea of deficiency type, injury thirst, spontaneous sweating, emission due to the kidney deficiency, spleen kidney deficiency, palpitation and insomnia.
Root of Chinese trichosanthes
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor：Bitter, micro-sweet, tremble with fear.Attach to the lung and stomach meridians.
Effect：Clearing heat and promoting fluid, detumescence and apocenosis.
Cure mainly：Hinder for pyreticosis Tianjin, dry, quench one's thirst, cough with lung heat, dryness of the lung hemoptysis, heat toxin sore carbuncle.
The tuber of dwarf lilyturf
Tonifying yin class Chinese medicine
Meridian distribution of property and flavor：Sweet, slight bitter, is slightly cold.Return lung, the heart, stomach.
Effect：Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire.
Cure mainly：It is thick for cough caused by dryness phlegm, overstrain cough spitting of blood, thirsty and dry pharynx, vexed insomnia.
The root of kudzu vine
Relieving the exterior syndrome with drugs pungent in flavor and cool in property class Chinese medicine
Meridian distribution of property and flavor：It is sweet, pungent, it is cool.Attach to the lung and stomach meridians.
Effect：Relieving muscles diaphoresis, promoting eruption, Shengyang Zhixie, promote the production of body fluid to quench thirst.
Cure mainly：For fever caused by exogenous pathogens, stiff nape and back, measles without adequate eruption, damp-heat dysentery, splenasthenic diarrhea, pyreticosis polydipsia, quench one's thirst
Card.
Clam meal
Nature and flavor：Taste is salty；It is cold in nature；
Channel tropism：Lung；Kidney；Liver Channel；
Major function：Heat-clearing；Resolving sputum dampness removing；Softening hard masses.Cure mainly stomachache；Sputum cough；Aqueous vapor edema；Urinary obstruction；Seminal emission；
Gonorrhoea；Metrorrhagia；Under band；Carbuncle swells；Goiter and tumor；Scald.
Bryozoatum
Classification：Expectorants, antitussives and anti-asthmatics medicine
Meridian distribution of property and flavor：It is cold；It is salty；Return lung passes through
Major function：Clearing lung and eliminating phlegm, softening and resolving hard mass.For phlegm-heat cough, the sticky person of phlegm, scrofula, goiter and tumor.
The membrane of a chicken's gizzard
The class that helps digestion Chinese medicine
Meridian distribution of property and flavor：It is sweet, put down.Returns spleen, stomach, small intestine, bladder warp.
Effect：Stomach strengthening and digestion promoting, controlling nocturnal emission with astringent drugs are only lost.
Cure mainly：For accumulation of food in the stomach and intes tine due to indigestion, infantile malnutrition, enuresis seminal emission, urolithiasis.
Watermelon peel
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor：It is sweet, light, it is cool in nature.The thoughts of returning home, stomach, bladder warp.Refrigerant solution profit.
Effect：Clear heat relieving restlessness, diuresis of quenching one's thirst.
Cure mainly：Cure mainly hot summer weather polydipsia, oliguresis, oedema, aphthae.
Waxgourd peel
Diuresis detumescence class Chinese medicine
Meridian distribution of property and flavor：It is sweet, it is slightly cold.Return lung, small intestinl channel.
Effect：Inducing diuresis for removing edema.
Cure mainly：For damp and hot oedema.
Mantis egg-case
Astringentses Chinese medicine
Meridian distribution of property and flavor：It is sweet, salty, put down.Return liver and kidney channel.
Effect：Astringent sperm contracting urine, tonify the kidney and support yang.
Cure mainly：For passing out semen, frequent micturition, the enuresis, impotence.
The wind-weed
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor：It is bitter, sweet, tremble with fear.Return lung, stomach, kidney channel.
Effect：Clearing heat-fire, nourishing Yin and moistening dryness.
Cure mainly：For warm heat disease high fever polydipsia, cough with lung heat, deficiency of Yin dry cough, osteopyrexia and fever, Heat Diabetes.
Radix Codonopsis
Tonifying Qi class Chinese medicine
Meridian distribution of property and flavor：It is sweet, put down.Returns spleen, lung channel.
Effect：Tonifying middle-Jiao and Qi, blood-nourishing of promoting the production of body fluid.
Cure mainly：For the deficiency of qi in middle-jiao, anorexia and loose stool, cough and asthma shortness of breath, injury thirst, blood deficiency chlorosis, palpitation and dizziness.
Gypsum
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor：It is pungent, sweet, Great Cold.Attach to the lung and stomach meridians.
Effect：Clearing heat-fire, relieving restlessness are quenched the thirst.
Cure mainly：For warm heat disease high fever polydipsia, lung heat cough and asthma, stomach fire headache, swelling and aching of gum；Sore is burst long, eczema, is scalded
Wound.
Radix scrophulariae
Clearing heat and cooling blood class Chinese medicine
Meridian distribution of property and flavor：It is bitter, sweet, salty, cold.Return lung, stomach, kidney channel.
Effect：Clearing heat and cooling blood, detoxicating and resolving a mass, Yin-nourishing and body fluid promoting.
Cure mainly：Joined the army point for heat, fever aggravated at night, blood-head hair spot, abscess of throat, carbuncle sore tumefacting virus, dry constipation of intestines.
Present invention also offers a kind of preparation method for the Chinese medicine for treating diabetes, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush and add ethanol water backflow 30-50 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 8-12MPa, 40-60 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.3-1.8g/ml medicinal extract；
5) by extract dry, preparation obtained by step 4).
Preferably, the weight fraction of the step 2) ethanol water is 65wt-75wt%.
Preferably, the condition of the step 5) drying is-78-- 60 DEG C of freeze-drying 12-20 hours.
Preferably, the step 5) preparation, auxiliary material by the medicinal extract and pharmaceutically are mixed, and the formulation includes mouth
Take liquid, granule, tablet, pill, powder, capsule, pill and injection.
The beneficial effects of the invention are as follows：
1st, the invention provides the Chinese prescription of the Chinese medicine for the treatment of diabetes, make full use of Chinese prescription theoretical, it is selected
Medicine, promoting blood circulation and removing blood stasis, kidney water rises internal heat drop, and the division of labor is clear and definite, and primary and secondary protrudes, and complementing each other, it is simultaneous to be taken into account while main symptom is treated
Card, the exquisite Overall View of Chinese prescription fully demonstrated, coordinated to see, treatment is comprehensive, curative for effect, shows by clinical verification effect
Write, Small side effects, can long-term use to diabetes and other uncomfortable positive effects as caused by diabetes.
2nd, present invention also offers a kind of preparation method for the Chinese medicine for treating diabetes, with reference to specific components in Chinese prescription
Property, be combined with existing extraction process, both ensured that effective ingredient has a higher dissolution rate, residual is few, and and can is protected
Card effective ingredient is not destroyed.
3rd, the Chinese Herbs for the treatment of diabetes provided by the invention protrude, and have no toxic side effect.
Embodiment
Embodiment 1
A kind of Chinese medicine for treating diabetes, by weight meter：5 grams of the red sage root, 3 grams of safflower, the dried rhizome of rehmannia, each 15 grams of Chinese yam；The five tastes
Son, each 5 grams of the root of kudzu vine；Each 10 grams of clam meal, bryozoatum；10 grams of root of Chinese trichosanthes, 3 grams of the membrane of a chicken's gizzard, watermelon peel, each 10 grams of waxgourd peel, mulberry Piao
50 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 5 grams of Radix Codonopsis, 10 grams of compositions of 25 grams of gypsum and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 65wt% ethanol waters 30 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 8MPa, 40 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.3g/ml medicinal extract；
5) auxiliary material by the freeze-drying 12 hours of -78 DEG C of medicinal extract obtained by step 4) and pharmaceutically is mixed and made into oral liquid.
Embodiment 2
A kind of Chinese medicine for treating diabetes, by weight meter：15 grams of the red sage root, 10 grams of safflower, the dried rhizome of rehmannia, each 25 grams of Chinese yam；Five
Each 15 grams of taste, the root of kudzu vine；Each 15 grams of clam meal, bryozoatum；20 grams of root of Chinese trichosanthes, 7 grams of the membrane of a chicken's gizzard, watermelon peel, each 20 grams of waxgourd peel, mulberry
70 grams of the egg capsule of a mantis, the wind-weed, the tuber of dwarf lilyturf, each 15 grams of Radix Codonopsis, 15 grams of compositions of 35 grams of gypsum and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 75wt% ethanol waters 50 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 12MPa, 60 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.8g/ml medicinal extract；
5) auxiliary material by the freeze-drying 20 hours of -60 DEG C of medicinal extract obtained by step 4) and pharmaceutically is mixed and made into granule.
Embodiment 3
A kind of Chinese medicine for treating diabetes, by weight meter：10 grams of the red sage root, 6 grams of safflower, the dried rhizome of rehmannia, each 20 grams of Chinese yam；The five tastes
Son, each 10 grams of the root of kudzu vine；Each 12 grams of clam meal, bryozoatum；15 grams of root of Chinese trichosanthes, 5 grams of the membrane of a chicken's gizzard, watermelon peel, each 15 grams of waxgourd peel, mulberry Piao
60 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 10 grams of Radix Codonopsis, 12 grams of compositions of 30 grams of gypsum and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 70wt% ethanol waters 40 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 10MPa, 500 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.5g/ml medicinal extract；
5) auxiliary material by the freeze-drying 18 hours of -70 DEG C of medicinal extract obtained by step 4) and pharmaceutically is mixed and made into injection.
Embodiment 4
A kind of Chinese medicine for treating diabetes, by weight meter：7 grams of the red sage root, 4 grams of safflower, the dried rhizome of rehmannia, each 17 grams of Chinese yam；The five tastes
Son, each 8 grams of the root of kudzu vine；Each 11 grams of clam meal, bryozoatum；13 grams of root of Chinese trichosanthes, 4 grams of the membrane of a chicken's gizzard, watermelon peel, each 13 grams of waxgourd peel, mulberry Piao
55 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 7 grams of Radix Codonopsis, 11 grams of compositions of gypsum 28 grams (being decocted first) and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 68wt% ethanol waters 34 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 9MPa, 44 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.4g/ml medicinal extract；
5) auxiliary material by the freeze-drying 16 hours of -74 DEG C of medicinal extract obtained by step 4) and pharmaceutically is mixed and made into tablet.
Embodiment 5
A kind of Chinese medicine for treating diabetes, by weight meter：9 grams of the red sage root, 7 grams of safflower, the dried rhizome of rehmannia, each 19 grams of Chinese yam；The five tastes
Son, each 9 grams of the root of kudzu vine；Each 13 grams of clam meal, bryozoatum；13 grams of root of Chinese trichosanthes, 6 grams of the membrane of a chicken's gizzard, watermelon peel, each 13 grams of waxgourd peel, mulberry Piao
65 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 13 grams of Radix Codonopsis, 13 grams of compositions of 32 grams of gypsum and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 71wt% ethanol waters 38 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 11MPa, 48 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.6g/ml medicinal extract；
5) the auxiliary material mf mass pil by the freeze-drying 17 hours of -70 DEG C of medicinal extract obtained by step 4) and pharmaceutically.
Embodiment 6
A kind of Chinese medicine for treating diabetes, by weight meter：13 grams of the red sage root, 8 grams of safflower, the dried rhizome of rehmannia, each 23 grams of Chinese yam；The five tastes
Son, each 13 grams of the root of kudzu vine；Each 14 grams of clam meal, bryozoatum；14 grams of root of Chinese trichosanthes, 4 grams of the membrane of a chicken's gizzard, watermelon peel, each 17 grams of waxgourd peel, mulberry Piao
68 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 14 grams of Radix Codonopsis, 14 grams of compositions of gypsum 34 grams (being decocted first) and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 73wt% ethanol waters 42 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 9MPa, 52 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.4g/ml medicinal extract；
5) the auxiliary material mf mass pil by the freeze-drying 18 hours of -68 DEG C of medicinal extract obtained by step 4) and pharmaceutically.
Embodiment 7
A kind of Chinese medicine for treating diabetes, by weight meter：14 grams of the red sage root, 4 grams of safflower, the dried rhizome of rehmannia, each 16 grams of Chinese yam；The five tastes
Son, each 6 grams of the root of kudzu vine；Each 11 grams of clam meal, bryozoatum；11 grams of root of Chinese trichosanthes, 4 grams of the membrane of a chicken's gizzard, watermelon peel, each 11 grams of waxgourd peel, mulberry Piao
52 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 6 grams of Radix Codonopsis, 11 grams of compositions of 28 grams of gypsum and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 74wt% ethanol waters 48 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 9MPa, 56 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.5g/ml medicinal extract；
5) auxiliary material by the freeze-drying 19 hours of -64 DEG C of medicinal extract obtained by step 4) and pharmaceutically is mixed and made into powder.
Embodiment 8
A kind of Chinese medicine for treating diabetes, by weight meter：8 grams of the red sage root, 6 grams of safflower, the dried rhizome of rehmannia, each 17 grams of Chinese yam；The five tastes
Son, each 13 grams of the root of kudzu vine；Each 13 grams of clam meal, bryozoatum；17 grams of root of Chinese trichosanthes, 6 grams of the membrane of a chicken's gizzard, watermelon peel, each 17 grams of waxgourd peel, mulberry Piao
68 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 14 grams of Radix Codonopsis, 14 grams of compositions of 29 grams of gypsum and radix scrophulariae.
Its preparation method, comprise the following steps：
1) clam meal, bryozoatum and gypsum are mixed and decocted, filtering, take supernatant；
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf,
Radix Codonopsis and radix scrophulariae cleaning, crush addition weight fraction and be 65wt ethanol waters 49 minutes, extract effective ingredient；
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exist
Extracting pressure 12MPa, 58 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；
4) the membrane of a chicken's gizzard is decocted and fries, crushes, mixed, concentrate with step 1), step 2) and step 3) gained effective ingredient
Into 1.7g/ml medicinal extract；
5) auxiliary material by -62 DEG C of freeze-drying 12-20 hours of medicinal extract obtained by step 4) and pharmaceutically is mixed and made into dripping pill
Agent.
Comparative example 1：The addition of mantis egg-case in embodiment 3 is become 30 grams, other are constant.
Comparative example 2：Mantis egg-case in embodiment 3 is replaced with cuttlebone, other are constant.
We's cube is at all：First, homogeny of clear fluid and blood, grows each other, deficiency of YIN-blood, sering is not filled；Second, scorching can
Disappear bright body fluid, consumes impairment of yin blood, hematogenous blockage, and extravasated blood is stagnated, this i.e. " for blood as if boat, as if water, water Tianjin is abundant in Tianjin, and boat begins to manage it,
If body fluid exhausts to be burnt, blood is retarded by silt for it "；Third, Yin and fluid deficiency, injures yang-energy, agitate powerless, stop in extravasated blood；Fourth, sugar
Urine disease is how touching refractory, and long void enters network, and pathogen usually intruding into collateral in protracted disease, qi and blood is not freely into becoming silted up, and this is i.e. " disease enters depth long, and it is puckery that battalion defends row ".Extravasated blood
Interior knot, strongly fragrant longization heat, the bright impairment of yin of heat, then it can cause or aggravate to quench one's thirst.
Tang Rongchuan exists《Treatise on blood trouble》Middle theory：" extravasated blood is inner i.e. thirsty ... blood and gas is not originally mutually from having extravasated blood inside, therefore gas is not
Must be logical, it is impossible to carry the rising of water Tianjin, the extravasated blood that is with thirsty ... goes then not thirsty ".
Silt choke is stagnant, aqueous dysbolism, Tianjin must not cloth, essence of water and grain must not moisten foster internal organs, four limbs bones of the body collectively, instead with
Urine and go, send out to quench one's thirst.It is the main pathogenesis of diabetes that the deficiency of Yin is scorching, and extravasated blood and the scorching reciprocal causation of the deficiency of Yin, with
The development of the state of an illness, causes yin and yang imbalance, produces many complication.
Extravasated blood is both a pathogenic factor, is a pathological product again, and extravasated blood can both cause diabetes, is also easy to produce again after being ill
Extravasated blood, aggravate disease, and easily trigger various complication again.So whole process of the extravasated blood through diabetes.
Prove, promoting blood flow and remove blood stasis drug can improve microcirculation disorder, accelerate microcirculation blood flow velocity, reduce blood viscosity, promote
Capillary network opens increase, (parteriole, veinlet, arteriole, micro- to internal different parts (heart and brain kidney etc.) and different type
Venous capillary) blood vessel have dilating effect, so as to increase local blood flow；For the thrombus formed, promoting blood circulationization
Silt medicine is then by suppressing platelet function, blood coagulation resisting function, increases FA, improves hemorheological property,
Reduce the effect that the links such as blood viscosity reach treatment.Ren Jixue distinguished veteran doctors of TCM thinks that disease and evil enters network, must activate blood circulation and disperse blood clots, and extravasated blood is not
OK, new blood is disconnected without life, new life to be caused, and must first push away old, leads to and mends parallel, often plus promoting circulation of blood medicine is in tonic, and its work(times is prompt, dispels silt not
For wound just because " quenching one's thirst " is using the deficiency of Yin as this, extravasated blood is that pathological product is pathogenic factor again, to be noted when application activates blood circulation and disperses blood clots
Meaning cares for shield qi and blood and nourishes yin-fluid, accomplish to dispel silt and will not gas consumption impairment of yin, yin-nourishing will not stay bandit's love heresy again, to reach preferable treatment
Effect.Diabetes are the longer disease of a treatment cycle again, to formulate the treatment plan of a long-term suitable personal feature, reach
To dispel become silted up do not hinder just, " with lead to for mend " effect.
It is the effective way for treating diabetes to propose to activate blood circulation and disperse blood clots, and should run through treating diabetes medicine for treatment principle all the time,
For improve therapeutic effect have positive effect, adjustment internal organs qi and blood function, treat both principal and secondary aspect of disease, silt of dispelling is not hindered just.
The clinical test of pesticide effectiveness
Method：By 220 clinical definite diabetics, the difference between individual patients can be neglected, and its is random
It is divided into experimental group 1-8, control group 1-2 and melbine group, every group 20, takes Chinese traditional medicine composition prepared by embodiment 1-8 respectively
Chinese medicine composition and commercially available melbine prepared by thing, control group 1-2, is continuously taken 10 days, and observation clinical efficacy result is shown in
Table 1, stop other western medicines in treatment during treatment.
Diagnostic criteria：Formulated within 1993 with reference to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》In " treatment disappears
The standard rating curative effect of the guideline of clinical investigations of thirsty disease " defined.It is effective：Symptom disappears substantially after treatment, and FPG is (on an empty stomach
Blood glucose) ＜ 7.0mmol/L, P2hPG (postprandial 2 hours blood glucose) ＜ 8.3mmol/L or blood glucose declines more than 30% earlier above；Effectively：
Symptom is obviously improved after treatment, and FPG ＜ 8.3mmol/L, P2hPG ＜ 10.0mmol/L, or blood glucose decline 10%~29% earlier above；
It is invalid：Symptom is not improved after treatment, and blood glucose, which declines, is not up to above-mentioned standard.
Chinese medicine composition, the Chinese medicine composition and two of control group treatment diabetes of the treatment diabetes of the present invention of table 1
First biguanides treatment diabetes clinical efficacy result statistics.
Wherein, total effectively case load=(effective+effective) in table.As it can be seen from table 1 Chinese medicine composition of the present invention
Clinically, achieve the effect of preferable, in selected diabetic, take Chinese traditional medicine composition described in 1-8 of the embodiment of the present invention
After thing 10 days, obvious effective rate is up to 80.0%, and total effective rate is up to 95%；Particularly embodiment 3, total effective rate is up to 100%.It is right
2 groups of ratio is similar with melbine group clinical efficacy.Illustrate that the Chinese Herbs for the treatment of diabetes provided by the invention are more prominent,
Meanwhile by contrasting, compatibility and weight ratio in embodiment 3 and the explanation inventive formulation of comparative example 1,2 between each medicine are shadows
An important factor for ringing curative effect of medication of the present invention.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area is common
Other modifications or equivalent substitution that technical staff is made to technical scheme, without departing from technical solution of the present invention
Spirit and scope, all should cover among scope of the presently claimed invention.
Claims (7)
- A kind of 1. Chinese medicine for treating diabetes, it is characterised in that：By weight meter：5-15 grams of the red sage root, 3-10 grams of safflower, the dried rhizome of rehmannia, Each 15-25 grams of Chinese yam；Each 5-15 grams of the fruit of Chinese magnoliavine, the root of kudzu vine；Each 10-15 grams of clam meal, bryozoatum；10-20 grams of root of Chinese trichosanthes, the membrane of a chicken's gizzard 3- 7 grams, watermelon peel, each 10-20 grams of waxgourd peel, 50-70 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 5-15 grams of Radix Codonopsis, 25-35 grams of gypsum With 10-15 grams of composition of radix scrophulariae.
- A kind of 2. Chinese medicine for treating diabetes according to claim 1, it is characterised in that：By weight meter：Red sage root 8-10 Gram, 5-8 grams of safflower, the dried rhizome of rehmannia, each 18-22 grams of Chinese yam；Each 8-12 grams of the fruit of Chinese magnoliavine, the root of kudzu vine；Each 12-14 grams of clam meal, bryozoatum；Smallpox 13-18 grams of powder, 4-6 grams of the membrane of a chicken's gizzard, watermelon peel, each 12-18 grams of waxgourd peel, 55-65 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 8- of Radix Codonopsis 12 grams, 12-14 grams of composition of 28-32 grams of gypsum and radix scrophulariae.
- A kind of 3. Chinese medicine for treating diabetes according to claim 1, it is characterised in that：By weight meter：10 grams of the red sage root, Each 20 grams of 6 grams of safflower, the dried rhizome of rehmannia, Chinese yam；Each 10 grams of the fruit of Chinese magnoliavine, the root of kudzu vine；Each 12 grams of clam meal, bryozoatum；15 grams of root of Chinese trichosanthes, the membrane of a chicken's gizzard 5 grams, watermelon peel, 12 grams of each 15 grams of waxgourd peel, 60 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 10 grams of Radix Codonopsis, 30 grams of gypsum and radix scrophulariae Composition.
- A kind of 4. preparation method of the Chinese medicine for the treatment of diabetes according to claim any one of 1-3, it is characterised in that：Bag Include following steps：1）Clam meal, bryozoatum and gypsum are mixed and decocted, filtering, takes supernatant；2）By the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis Cleaned with radix scrophulariae, crush and add ethanol water 30-50 minutes, extract effective ingredient；3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction are extracting Pressure 8-12MPa, 40-60 DEG C of extraction temperature, it is standby that safflower effective ingredients are made；4）The membrane of a chicken's gizzard is decocted and fries, crush, with step 1）, step 2）With step 3）The mixing of gained effective ingredient, it is condensed into 1.3-1.8g/ml medicinal extract；5）By step 4）Gained extract dry, preparation.
- 5. preparation method according to claim 4, it is characterised in that：Step 2）The weight fraction of the ethanol water is 65wt-75wt%。
- 6. preparation method according to claim 4, it is characterised in that：Step 5）The condition of the drying is-78-- 60 DEG C It is freeze-dried 12-20 hours.
- 7. preparation method according to claim 4, it is characterised in that：Step 5）The preparation, by the medicinal extract and pharmacy On auxiliary material be mixed, the formulation includes oral liquid, granule, tablet, pill, powder, capsule, pill and injection Agent.
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