CN104800543A - Traditional Chinese medicine composition for treating influenza as well as preparation method and use thereof - Google Patents
Traditional Chinese medicine composition for treating influenza as well as preparation method and use thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating influenza as well as a preparation method and use thereof. The traditional Chinese medicine composition comprises 30-45 parts of Indian kalimeris herb, 30-45 parts of fiveleaf gynostemma rhizome or herb, 15-25 parts of lilies, 15-25 parts of european verbena herb and 8-14 parts of Tibet milkwort roots. The traditional Chinese medicine composition disclosed by the invention can be prepared into any orally taken medicine preparation which is clinically acceptable according to a conventional preparation method of traditional Chinese medicines. The traditional Chinese medicine composition disclosed by the invention has the efficacies of clearing heat, removing toxicity, dispelling wind, eliminating dampness, promoting the dispersing function of the lung, relieving a cough and cooling blood to induce diuresis, clinic curative effects indicate that the traditional Chinese medicine composition disclosed by the invention has precise and reliable curative effects on the influenza, and the traditional Chinese medicine composition can treat both manifestation and root cause of the influenza, is safe in clinical application and is free from toxic and side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to one and treat grippal Chinese medicine composition and its production and use, belong to grippal treatment by Chinese herbs field.
Background technology
Influenza is a kind of common acute febrile respiratory infectious disease, is also the disease that a kind of infectiousness is strong, spread speed is fast.Pathogen is first, second, the third three type influenza viruss, and mainly through droplet transmission, clinical manifestation is projection fear of cold, high heat, headache, systemic pain, the weak and weary systemic toxicity profiles symptom such as weak, and with slight respiratory symptom.Primary disease has self limiting, and the course of disease is shorter.On epidemiology, most distinguishing feature is: break out suddenly, rapid spread, involve wide, have certain seasonality (northern China generally occurs in winter, and mostly occurs in summer and winter in south).
At present, be used for the treatment of grippal Chinese patent medicine also existing all in various degree and take effect slow, the defect such as curative effect is remarkable not, have much room for improvement.
Summary of the invention
Technical problem to be solved by this invention be overcome existing for existing treatment influenza take effect slow, curative effect not significantly, defect, the grippal Chinese medicine composition for the treatment of provide a kind of instant effect, determined curative effect, having no side effect such as toxic and side effects is large;
Another technical problem to be solved by this invention is to provide a kind of method preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
One treats grippal Chinese medicine composition, comprises each component of following weight portion: Herba Kalimeridis, Herba Gynostemmatis, Bulbus Lilii, Herba Verbenae, Radix Polygalae Crotalarioidis.
Preferably, the weight portion of each component is: Herba Kalimeridis 30-45 part, Herba Gynostemmatis 30-45 part, Bulbus Lilii 15-25 part, Herba Verbenae 15-25 part, Radix Polygalae Crotalarioidis 8-14 part.
Most preferred, the weight portion of each component is: Herba Kalimeridis 35 parts, Herba Gynostemmatis 35 parts, Bulbus Lilii 20 parts, Herba Verbenae 20 parts, Radix Polygalae Crotalarioidis 11 parts.
Herba Kalimeridis: be herb and the root of feverfew Herba Kalimeridis.Nature and flavor: cool, pungent.Function cures mainly: removing heat from blood, heat clearing away, dampness removing, removing toxic substances, detumescence.Control haematemesis, epistaxis, dysentery, metrorrhagia, wound hemorrhage, jaundice, edema, stranguria with turbid discharge, pharyngalgia, sore throat, hemorrhoid, carbuncle, erysipelas etc.
Herba Gynostemmatis: be root stock or the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli.Nature and flavor: bitter in the mouth, cold in nature, nontoxic.Function cures mainly: clear scorching removing toxic substances, eliminating phlegm and stopping cough, controls chronic tracheitis.
Bulbus Lilii: be liliaceous plant Bulbus Lilii, Lilium tenuifolium, Lilium longiflorum and the scale leaf belonging to various plants bulb together.Nature and flavor: sweet micro-hardship, flat.GUIXIN, lung meridian.Function cures mainly: nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Control pulmonary tuberculosis chronic cough, cough and spit expectorant blood; Calentura waste heat is unclear, and fidgets due to deficiency is palpitated with fear, and mind is in a trance; Beriberi edema.
Herba Verbenae: be herb or the whole herb with root of Verbenaceae Herba Verbenae.Nature and flavor: bitter, cool.Return liver, spleen channel.Function cures mainly: promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control fever caused by exogenous pathogens, jaundice due to damp-heat, edema, dysentery, malaria, diphtheria, sore throat, gonorrhea, malaria, amenorrhea , mass in the abdomen, carbuncle sore tumefacting virus, ulcerative gingivitis.
Radix Polygalae Crotalarioidis: be the root of milk wort Radix Polygalae Crotalarioidis.Nature and flavor: sweet, temperature.Function cures mainly: heart tonifying and tranquilizing, eliminates the phlegm.Cure mainly palpitation due to deficiency of blood, insomnia and dreamful sleep, cough expectorant waits disease less.
Chinese medicine composition of the present invention be based on inventor's popularity flu the pathogenetic research of deep layer and Therapeutic Principle, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, filter out the crude drug of heat-clearing and toxic substances removing, expelling wind and removing dampness, lung qi dispersing cough-relieving, removing pathogenic heat from blood and inducing diuresis, form according to certain weight proportion prescription.
There is when adding Rhizoma actaeae asiaticae, Herba Menthae, this 3 kinds of components of Cortex Populi Davidianae further in above-mentioned Chinese medicine composition better grippal effect for the treatment of; Preferably, the weight portion of each component is: Rhizoma actaeae asiaticae 6-13 part, Herba Menthae 5-9 part and Cortex Populi Davidianae 4-8 part; Preferred, the weight portion of each component is: Rhizoma actaeae asiaticae 9 parts, Herba Menthae 7 parts and Cortex Populi Davidianae 6 parts.
Rhizoma actaeae asiaticae: be the rhizome of ranunculaceae plant leaf Rhizoma Cimicifugae.Nature and flavor: pungent micro-hardship are cool.Function cures mainly: expelling pathogenic wind from the body surface, reducing fever relieving cough.
Herba Menthae: be herb or the leaf of labiate Herba Menthae or Herba Menthae.Nature and flavor: pungent are cool.Return lung meridian, Liver Channel.Function cures mainly: dispelling wind, and heat radiation, wards off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.
Cortex Populi Davidianae: be the bark of Salicaceous Plants Populus davidiana.Nature and flavor: bitter, cold.Function cures mainly: dispel the wind, clots absorbing, expectorant.Control migratory arthralgia, beriberi, flutter damage blood stasis, pregnant dysentery, toothache, aphtha.
In side of the present invention, each medicine compatibility plays effect of heat-clearing and toxic substances removing, expelling wind and removing dampness, lung qi dispersing cough-relieving, removing pathogenic heat from blood and inducing diuresis together altogether, Chinese medicine composition of the present invention is for influenza treating both the principal and secondary aspects of a disease, clinical observation on the therapeutic effect confirms, Chinese medicine composition of the present invention is reliable for influenza determined curative effect, true.Chinese medicine composition of the present invention is nontoxic, safe and reliable, has no adverse reaction after taking, Clinical practice safety.
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., be prepared into the suitable clinical oral administration preparation of any one with the method for Chinese medicinal of routine, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid, drop pill etc.
A kind of preparation method of Chinese medicine composition of the present invention: after being taken by described weight by each crude drug of the present invention, pulverize, sieve (can be such as 80-300 mesh sieve), to obtain final product.Certainly, after also each crude drug can being pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared into capsule, tablet or pill.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as age, health status of concrete dosage form, patient.As guidance: usage and dosage: capsule, each capsule content 0.4 gram of crude drug, oral 1 to 3 at every turn, 3 times on the one.
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment; these embodiments are only exemplary; what those skilled in the art should understand that is; can modify to the details of technical solution of the present invention and form lower without departing from the spirit and scope of the present invention or replace, but these amendments and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
Each crude drug (unit: g): Herba Kalimeridis 30, Herba Gynostemmatis 30, Bulbus Lilii 15, Herba Verbenae 15, Radix Polygalae Crotalarioidis 8 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 2 capsule
Each crude drug (unit: g): Herba Kalimeridis 45, Herba Gynostemmatis 45, Bulbus Lilii 25, Herba Verbenae 25, Radix Polygalae Crotalarioidis 14 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 3 capsule
Each crude drug (unit: g): Herba Kalimeridis 35, Herba Gynostemmatis 35, Bulbus Lilii 20, Herba Verbenae 20, Radix Polygalae Crotalarioidis 11 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 4 capsule
Each crude drug (unit: g): Herba Kalimeridis 30, Herba Gynostemmatis 30, Bulbus Lilii 15, Herba Verbenae 15, Radix Polygalae Crotalarioidis 8, Rhizoma actaeae asiaticae 6, Herba Menthae 5, Cortex Populi Davidianae 4 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 5 capsule
Each crude drug (unit: g): Herba Kalimeridis 45, Herba Gynostemmatis 45, Bulbus Lilii 25, Herba Verbenae 25, Radix Polygalae Crotalarioidis 14, Rhizoma actaeae asiaticae 13, Herba Menthae 9, Cortex Populi Davidianae 8 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 6 capsule
Each crude drug (unit: g): Herba Kalimeridis 35, Herba Gynostemmatis 35, Bulbus Lilii 20, Herba Verbenae 20, Radix Polygalae Crotalarioidis 11, Rhizoma actaeae asiaticae 9, Herba Menthae 7, Cortex Populi Davidianae 6 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The grippal clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating of the present invention
One, physical data: 240 routine patients all meet grippal diagnostic criteria, and patient is divided into 2 groups at random, often organizes 120 examples; 2 groups of no significant differences on sex, age, the course of disease and coincident with severity degree of condition.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-6.
Three, Therapeutic Method
240 routine patients are divided into 2 groups at random, that is: test 1 group and test 2 groups, often organize each 120 example, test 1 group adopt prepared by embodiment 1-3 capsule treatment, test 2 groups adopt prepared by embodiment 4-6 capsule treatment; Oral, one time 3 (0.4g crude drug/grain), 3 times on the one, the morning, noon and afternoon respectively once, treat 5 days altogether; Period in a medicine withdraws other related drugs and other treatment.
Four, efficacy assessment standard
Recovery from illness: cold symptoms disappears, without complication.
Effective: cold symptoms is alleviated, and clinical symptoms is obviously improved;
Invalid: cold symptoms does not take a turn for the better, or develop complications.
Five, clinical observation result
Clinical observation result is in table 1.
The grippal clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating of the present invention
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for patients with influenza; Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (7)
1. treat a grippal Chinese medicine composition, it is characterized in that, be made up of following component: Herba Kalimeridis, Herba Gynostemmatis, Bulbus Lilii, Herba Verbenae, Radix Polygalae Crotalarioidis.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each component is: Herba Kalimeridis 30-45 part, Herba Gynostemmatis 30-45 part, Bulbus Lilii 15-25 part, Herba Verbenae 15-25 part, Radix Polygalae Crotalarioidis 8-14 part.
3. according to Chinese medicine composition according to claim 2, it is characterized in that, the weight portion of each component is: Herba Kalimeridis 35 parts, Herba Gynostemmatis 35 parts, Bulbus Lilii 20 parts, Herba Verbenae 20 parts, Radix Polygalae Crotalarioidis 11 parts.
4. treat a grippal Chinese medicine composition, comprise each component composition of following weight portion: Herba Kalimeridis 30-45 part, Herba Gynostemmatis 30-45 part, Bulbus Lilii 15-25 part, Herba Verbenae 15-25 part, Radix Polygalae Crotalarioidis 8-14 part, Rhizoma actaeae asiaticae 6-13 part, Herba Menthae 5-9 part, Cortex Populi Davidianae 4-8 part.
5. according to Chinese medicine composition according to claim 4, it is characterized in that, the weight portion of each component is: Herba Kalimeridis 35 parts, Herba Gynostemmatis 35 parts, Bulbus Lilii 20 parts, Herba Verbenae 20 parts, Radix Polygalae Crotalarioidis 11 parts, Rhizoma actaeae asiaticae 9 parts, Herba Menthae 7 parts, Cortex Populi Davidianae 6 parts.
6. prepare a method for claim 1-5 Chinese medicine composition described in any one, comprise the following steps:
(1), each crude drug is taken by described weight proportion;
(2), by each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
7. the purposes of claim 1-5 Chinese medicine composition described in any one in preparation treatment influenza medicine.
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Application publication date: 20150729 |