CN103239662A - Parasite expelling Chinese herbal preparation for animals - Google Patents

Abstract

The invention provides a parasite expelling Chinese herbal preparation for animals, which is obvious in treating effect, economic, effective and convenient, has no toxic and side effects and is prepared by the following raw materials parts by weight: 30-40 parts of areca catechu, 30-40 parts of dried lacquer, 30-40 parts of sophora flower, 30-40 parts of subprostrate sophora, 30-40 parts of chinaberry leaves, 30-40 parts of winged euonymus twig, 30-40 parts of common carpesium fruit, 20-30 parts of akebia fruit, 20-30 of parts veratrum nigrum, 20-30 of parts radix stemonae, 20-30 parts of quisqualis indica, 20-30 parts of ferula asafoetida, 20-30 parts of polygonum aviculare, 20-30 parts of Chinese torreya, 10-20 pats of pericarpium zanthoxyli, 10-20 of parts purslane, 10-20 parts of pumpkin seeds, 10-20 parts of camphor tree leaves, 10-20 parts of large leaf wolf bean stick leaves, 10-20 parts of garlic, 1-10 parts of calomel, 1-10 parts of dry lotus, 1-10 parts of pepper, 1-10 parts of brown sugar, 1-10 of parts fructus ulmi, 1-10 parts of oleum menthae and 1-10 parts of soybean oil.

Description

Veterinary anthelmintic traditional Chinese medicine preparation

technical field

The invention relates to the field of traditional Chinese medicines, in particular to a veterinary anthelmintic traditional Chinese medicine preparation.

Background technique

In animal husbandry, albimazole and abamectin have been widely used in my country for many years to drive and treat internal and external parasitic diseases of livestock. In the process of parasitic diseases, there are practical problems such as large waste of drugs, high drug prices, difficulty in administration, and high labor intensity. In foreign countries, the anthelmintic drugs are basically the same as those in our country.

So far, it is urgent to provide a medicine that has remarkable therapeutic effect, no toxic and side effects, and is economical, effective and convenient for expelling internal and external parasites of domestic animals.

Contents of the invention

The object of the present invention is to provide a medicine for expelling internal and external parasites in domestic animals, which has remarkable therapeutic effect, no toxic and side effects, is economical, effective and convenient: traditional Chinese medicine preparation for anthelmintic for animals.

Veterinary anthelmintic traditional Chinese medicine preparation is characterized in that it consists of the following raw materials in parts by weight:

30-40 parts of betel nut, 30-40 parts of dry paint, 30-40 parts of Sophora japonica, 30-40 parts of mountain bean root, 30-40 parts of neem leaf, 30-40 parts of ghost arrow feather, 30-40 parts of crane lice, 20-30 servings of Chizhizi, 20-30 servings of Veratrum, 20-30 servings of Baibu, 20-30 servings of Shijunzi, 20-30 servings of Ferulicum, 20-30 servings of Chinese Torreya, 20-30 servings of Torreya, Chuanjiao 10-20 parts of purslane, 10-20 parts of purslane, 10-20 parts of pumpkin seeds, 10-20 parts of camphor tree leaves, 10-20 parts of big-leaved wolf bean chai leaves, 10-20 parts of garlic, 1-10 parts of light powder , 1-10 parts of Eclipta, 1-10 parts of Zanthoxylum bungeanum, 1-10 parts of sugar, 1-10 parts of turnip, 1-10 parts of peppermint oil, 1-10 parts of soybean oil;

Preparation:

1) Extract, separate, dry, and pulverize other ingredients except peppermint oil and soybean oil according to the formula ratio;

2) The powder obtained in Preparation Method 1 is mixed with peppermint oil and soybean oil in proportion, mixed evenly, and dried to make tablets, capsules, oral preparations, smears, and sprays.

Veterinary anthelmintic traditional Chinese medicine preparation is characterized in that it consists of the following raw materials in parts by weight:

32-38 parts of betel nut, 32-38 parts of dry paint, 32-38 parts of Sophora japonica, 32-38 parts of mountain bean root, 32-38 parts of neem leaf, 32-38 parts of ghost arrow feather, 32-38 parts of crane lice, 22-28 servings of Zhizhizi, 22-28 servings of Veratrum, 22-28 servings of Baibu, 22-28 servings of Shijunzi, 22-28 servings of Ferulicum, 22-28 servings of Chinese Torreya, 22-28 servings of Torreya, Chuanjiao 12-18 parts, 12-18 parts of purslane, 12-18 parts of pumpkin seeds, 12-18 parts of camphor tree leaves, 12-18 parts of big-leaved wolf bean chai leaves, 12-18 parts of garlic, 2-8 parts of light powder , 2-8 parts of Eclipta, 2-8 parts of Zanthoxylum bungeanum, 2-8 parts of sugar, 2-8 parts of turnip, 2-8 parts of peppermint oil, and 2-8 parts of soybean oil.

Veterinary anthelmintic traditional Chinese medicine preparation is characterized in that it consists of the following raw materials in parts by weight:

35 parts of betel nut, 35 parts of dried lacquer, 35 parts of Sophora japonica, 35 parts of mountain bean root, 35 parts of neem leaf, 35 parts of ghost arrow feather, 35 parts of crane lice, 25 parts of prophetic seed, 25 parts of veratrum, 25 parts of hundred parts , 25 parts of Gentleman, 25 parts of Ferulicum, 25 parts of 萹节, 25 parts of Torreya japonica, 15 parts of Chuanjiao, 15 parts of purslane, 15 parts of pumpkin seeds, 15 parts of camphor tree leaves, 15 parts of wolfberry leaves, 15 parts of garlic, 5 parts of light powder, 5 parts of eclipse flower, 5 parts of pepper, 5 parts of sugar, 5 parts of turnip, 5 parts of peppermint oil, and 5 parts of soybean oil.

The present invention relates to the pharmacology and property of medicine of Chinese medicine:

Betel nut:

[meridians distribution of property and flavor] bitter, pungent, warm; enter spleen, stomach, large intestine channel.

[Function] kills insects, destroys stagnation, lowers qi, and promotes water. Control worm accumulation, food stagnation, abdominal distension and pain, diarrhea and dysentery, malaria, edema, beriberi, phlegm addiction, crux.

Dry paint:

[meridian distribution of property and flavor] pungent, warm; poisonous. Return liver, spleen channel. the

[functions and indications] breaking blood stasis, eliminating stagnation, killing parasites. For women's amenorrhea, blood stasis syndrome, abdominal pain due to worm accumulation.

Sophora japonica: nature, flavor and meridian distribution: bitter, slightly cold. Return liver, large intestine channel. Functions and indications: cool blood to stop bleeding, lower blood pressure. For vomiting blood, blood in the stool, hemorrhoids bleeding, hematuria metrorrhagia, hypertension. Appropriate amount for external use. To stop bleeding, it is often used to stir-fry charcoal;

Shantou root:

[meridian distribution of nature and flavor] sweet in taste, cold in taste, enters the three meridians of heart, lung and large intestine;

[Functions and Indications] Non-toxic, heat clearing, detoxification, detumescence, pain relief. Cure throat carbuncle, throat wind, throat numbness, swollen gums, hot cough with dyspnea, jaundice, diarrhea, hemorrhoids, heat swelling, bald sores, scabies, snakes, insects, dog bites.

【Drug Compatibility】With chrysanthemum, it is used for dizziness and blurred vision due to liver and kidney deficiency, and has the effect of improving eyesight. Combined with Rehmannia glutinosa, it can be used in conjunction with liver and kidney yin deficiency, soreness of the waist and knees, irregular menstruation, nocturnal emission, and premature aging. It can also be used for dizziness, tinnitus, and dim eyesight due to insufficient liver and kidney essence and blood. Combined with Radix Ginseng, it is used for cough and dry throat due to lung, stomach and yin injury, yin deficiency and tuberculosis, diabetes and nausea, and fever and yin injury. With Ligustrum lucidum, it is used for dizziness, blurred vision, cloudy eyes or sudden blindness, premature graying of the beard and hair, soreness of the waist and knees for patients with insufficient liver and kidney essence and blood. Combined with Cuscuta, it is suitable for treating deficiency of kidney essence, dizziness of the eyes due to loss of liver blood, dim vision, nocturnal emission, premature ejaculation, dizziness, tinnitus, and low back pain. Combined with Radix Polygoni Multiflori, nourish liver and kidney, nourish essence and blood, black hair and strengthen tendons. Combined with Ophiopogon japonicus, it is used for febrile disease and yin deficiency, yin deficiency and dryness of the lungs, diabetes and nausea, and has a coordinating effect. Combined with sealwort, it can nourish yin and blood, wolfberry helps sealwort nourish yin and moistens lungs, sealwort helps wolfberry nourish yin and blood, and it is used as needed.

Neem leaves:

[Meridians of Nature and Flavor] "Guangdong Traditional Chinese Medicine" II: "Bitter, cold, and slightly poisonous." Liver, lung, and large intestine meridians.

【Function】Pain relief, parasite killing. Control hernia, roundworm, bruises, boils, skin eczema.

Ghost Arrow Feather:

Wei Spear, also known as Ghost Arrow Feather, Ghost Arrow, Liuyueling, Four-faced Front, Puji Chai, Four-Length Tree, Pheasant Tiaozi, Four-faced Halberd, Jianshuangxiao, and anesthetic. A winged branch or wing-like appendage of Euonymus euonymus. It can be harvested throughout the year. After cutting the branches, remove the twigs and leaves and dry them in the sun. Or collect its wings and dry them in the sun. It has the effects of dispelling blood and promoting menstrual flow; detoxifying and detumescence; killing parasites.

[nature and flavor] are bitter; Pungent; Cold.

① "The Classic": bitter, cold.

② "Wu Pu Materia Medica": Bitter, non-toxic.

③ "On the Properties of Medicine": slightly poisonous.

④ "Nihuazi Materia Medica": sweet and astringent.

⑤ "Compendium": sour taste.

[return through]: Liver Channel.

① "Summary of Materia Medica": Enters the Foot Jueyin Meridian.

【Efficacy and action】Break blood to stimulate menstrual flow; detoxify and reduce swelling; kill parasites. The main symptoms are lumps in the abdomen; abdominal pain; amenorrhea; dysmenorrhea; metrorrhagia; postpartum stasis abdominal pain; hurt.

① "The Classic": The main female collapses with bleeding, and the abdomen is full of sweat.

② "Bie Lu": the main nausea and abdominal pain, white worms, eliminate skin wind, poison and swelling, so that the solution in the yin.

③ "On the Properties of Medicine": broken old blood, abortion. The main evil is waist and abdominal pain.

④ "Tang Materia Medica": treating women's blood energy.

⑤ "Nihuazi Materia Medica": clear menstruation, break the crux of the disease, stop bleeding and metrorrhagia, leukorrhagia, kill abdominal viscera, and postpartum blood colic and abdominal pain.

6. "General Object Name and Fact Map Examination": Control swelling and poison.

[Clinical Application] Promoting blood circulation to stimulate menstruation, dissipating blood stasis and relieving pain. For irregular menstruation, postpartum congestion and abdominal pain, swelling and pain due to traumatic injuries.

Crane lice:

[meridian distribution of property and flavor] bitter, flat, poisonous. ① "Tang Materia Medica": "Bitter, flat, slightly poisonous." ② "Compendium": "Bitter, slightly poisonous." ③ "Yilin Zhuanyao": "Bitter, warm." Into the spleen and stomach , liver channel; "

[Efficacy] Kill insects, clear away heat and detoxify, invigorate the spleen and stomach. the

[Indications] Treatment of abdominal pain due to worms, vaginal trichomonas; Tian has anthelmintic effect, 1% crane lice mixed with 5 drops in 25ml of human saline, warmed to 37°C and then released Taenia magna, the result died within 1-2 minutes. the

Predictor:

【Release name】: Shengzhizi, Shengxianzi, Xihezi, Xianzhaozi.

【Odor】: (seed, benevolence) bitter, cold, non-toxic.

【Indications】: 1. Mental illness (sufficiency of energy, trance, erratic speech, palpitations and depression, worry about misfortunes, fanaticism of joy and anger, forgetfulness and less sleep, frequent nights and strange dreams, madness and unknown people). Divide into powder with the seeds of Predict (peeled), white tuckahoe, medlar, Shicaopu, Fushen, Baiziren, Renhu, Digupi, polygala, yam, sealwort (steamed), and cinnabar (water fly). , add refined honey and make into balls, and make Gorgon seeds big. Every time you chew a pill, you will get ginseng soup as a gift.

2. Fever wind (eyebrows falling, voice changing). Use two liang each of Zhizhizi and Xionghuang, and research together to make the end. In addition, three liang of frankincense is mixed with a bucket of water, boiled to five liters, added with powdered medicine, boiled into a paste, and stored in a bottle. A spoonful before death, warm wine down.

[Meridian distribution of property and flavor] ① "Rihuazi Materia Medica": "warm." ② "Kaibao Materia Medica": "bitter in the mouth, cold, non-toxic." Enters the lung and kidney two channels.

【Efficacy Classification】Heat-clearing medicine, heat-clearing and detoxifying medicine

[Efficacy and Indications] Clearing away heat and detoxification, diuresis and swelling, regulating qi and harmonizing stomach, killing insects and relieving itching. Control ascariasis, abdominal distension.

Veratrum:

[Efficacy] Emit wind-phlegm, clear away heat and detoxify, kill insects.

[Indications] Treatment of wind-phlegm surge, wind epilepsy, jaundice, chronic malaria, dysentery, headache, sore throat, snoring, scabies, and malignant sores. In addition, the powder of this product is extravasated, which has the effect of killing lice. expectorant, vomiting, parasite killing. For apoplexy, phlegm stagnation, epilepsy, malaria, bone fractures; external use for scabies and fly maggots.

[nature and flavor] bitter, cold, poisonous.

① "The Classic": "Pungent, cold."

② "Bie Lu": "bitter, slightly cold, poisonous"

[Return to the classics] "Materia Medica Classics": "Start with the Taiyin and Foot Yangming Meridians." "Materia Medica Zaixin" "Enter the Liver Meridian."

Hundred:

[meridian distribution of property and flavor] sweet, bitter, slightly warm. Return lung meridian.

[Functions and Indications] Moisturizing the lungs, lowering qi, relieving cough, and killing parasites. For chronic cough, tuberculosis cough, pertussis; externally for head lice, body lice, pinworms, pruritus vulvae. Moisturizing the lungs and relieving cough. For cough due to yin deficiency.

Make a gentleman:

【Meridians of Sex and Flavor】Warm in nature and sweet in taste, enters the spleen, stomach, and large intestine meridians,

[Efficacy] It has the effects of killing insects, eliminating stagnation, and invigorating the spleen. Its sweetness and warmth are mild, not warm and dry, so it can help the movement of food and drink, and relieve stagnation in the intestines, and is rich in fat, so it is smooth and smooth. Ferulic:

Spicy and warm in taste, it has the effects of regulating qi and reducing swelling, promoting blood circulation and eliminating fatigue, eliminating phlegm and stimulating nerves. Uighur doctors also use it to deworm, treat vitiligo and traditional methods;

Nature and flavor: bitter, pungent, warm.

Return through: return kidney, stomach meridian.

Efficacy: eliminating stagnation, dispelling lumps, killing insects. Used for stagnation of meat, blood stasis syndrome, mass in the abdomen, and abdominal pain due to worm accumulation.

Savings:

Bitter, slightly cold. Return bladder channel. This product is bitter and descends, tonifies the bladder, bitter and dry, and can kill insects, dehumidify and relieve itching. It is mainly used for gonorrhea and eczema.

1. Lishuitonglin is used for damp-heat stranguria syndrome, and can treat urinary tract infection, stones, hematuria, etc.

2. Killing insects and relieving itching can treat parasitic diseases such as pinworms. It can also be decocted and washed externally to treat skin sores and itching.

3. Treat red and white dysentery, jaundice.

Torreya:

[nature and flavor] sweet, flat. ① "The Classic": "Sweet, warm." ② "Bie Lu": "Poisonous." ③ "Qian Jin Shi Zhi": "Sweet and astringent, non-toxic."

[return through] enters lung, stomach, large intestine channel. ① "Materia Medica Classics": "Start with the Taiyin and Yangming meridians." ② "New Compilation of Materia Medica": "Enter the stomach, spleen, and large intestine meridians, and then enter the lungs." 

[Functions and Indications] Killing insects, eliminating stagnation, moistening dryness. Control worm accumulation abdominal pain, infantile malnutrition, dry cough, constipation, hemorrhoids. ① "The Classic": "Maintains evil spirits in the abdomen, removes three worms, and snake stings." ② "Bie Lu": "Maintains five hemorrhoids." ③Tao Hongjing: "Cure Cunbai." , eliminate grains, help muscles and bones, run camp and defend, and improve eyesight." ⑤ "Daily Materia Medica": "Kills large and small worms in the abdomen, children are yellow and thin, and those who have worms in the abdomen will heal after eating. Chew and eat with shells , eliminate phlegm." ⑥ "Sheng Editor-in-Chief": "Cure cough, white turbidity, and help Yang." ⑦ "Compendium of Materia Medica": "Moisturize the lungs and kill insects." Gong." ⑨ "Materia Medica Zaixin": "Treat lung fire, invigorate spleen soil, invigorate qi and reduce phlegm, relieve cough, calm asthma, remove blood stasis and generate new energy."

Chuanjiao:

[meridian distribution of property and flavor] pungent, warm. Return spleen, stomach, kidney channel. the

[Functions and Indications] Warming middle-JIAO to relieve pain, killing parasites and relieving itching. For epigastric cold pain, vomiting and diarrhea, worm accumulation abdominal pain, ascariasis; external treatment of eczema itching.

[Excerpt] "Chinese Pharmacopoeia".

purslane:

[meridian distribution of property and flavor] sour, cold; return liver, large intestine channel.

[Functions and Indications] It is suitable for dysentery (stool is semi-dry and semi-loose), clearing heat and detoxifying, cooling blood and stopping bleeding. For toxic heat and bloody dysentery, carbuncle and furuncle, eczema, erysipelas, snake bites, blood in the stool, hemorrhoids, metrorrhagia. In modern times, it is mostly used for the treatment of enteritis, acute arthritis, cystitis, urethritis, anus, bleeding hemorrhoids, etc. The textual research comes from "Materia Medica Collection Notes" and "Materia Medica Tujing": Purslane, also known as five-element grass, is known for its green leaves, red stems, yellow flowers, white roots, and black seeds. Indications: pyretic toxin diarrhea, hot stranguria, anuria, red and white vaginal discharge, metrorrhagia, hemorrhoids, sores, carbuncles, erysipelas, scrofula, tinea eczema, alopecia areata. "Southern Yunnan Materia Medica": nourishing qi, clearing heat, widening the middle and lowering qi, moistening the intestines, eliminating stagnation, killing insects, and treating sores, redness, swelling and pain. the

pumpkin seeds:

[nature and flavor] neutral in nature, sweet in taste. the

[Functions and Indications] Deworming, detumescence. For the treatment of tapeworms, roundworms, postpartum hand and foot edema, whooping cough, and hemorrhoids.

Camphor leaves:

[Sex and flavor] "Lu Chuan Materia Medica": "Bitter and pungent, warm."

[function cures mainly] expelling wind, removing dampness, relieving pain, killing parasites. Control rheumatic bone pain, bruises, scabies. the

Big-leaf wolf bean and firewood leaves:

[meridian distribution of nature and flavor] acrid in taste; bitter; warm in nature.

[function cures mainly] parasite killing; antipruritic athlete's foot; scabies.

garlic:

[Meridian distribution of nature and flavor] Warm in nature, pungent in taste; human spleen, stomach, and lung meridians.

【Functions and Indications】For dysentery and diarrhea, tuberculosis. Cough, intestinal parasitic diseases (hookworm, enterobiasis), sores, carbuncles, swollen toxins and other diseases. 1. To dissipate carbuncle and eliminate stagnation, detoxify and kill insects: mainly treat carbuncle sores, ringworm sores and itching. Smashed for external application or sliced for external rubbing. 2. Detoxification: used for pulmonary tuberculosis cough, dysentery and diarrhea. 3. Insecticide: used for hookworm disease and roundworm disease, it can be decocted with anthelmintic medicine. For hookworm disease, this product can also be used for prevention. Before going to work in the field, smash the garlic and apply it to the limbs. For roundworm disease, you can also mash this product, add a little vegetable oil, and apply it around the anus before going to bed. In addition, raw food of this product can also prevent and treat influenza.

light powder:

[nature and flavor] pungent, cold, poisonous, enter liver, kidney channel;

[Efficacy] Attacks poison, diuresis, laxative, cures scabies, scrofula, syphilis, chancre, skin ulcers, edema, bloating, constipation.

Ecliptas:

[nature and flavor] "Guangxi Chinese Herbal Medicine": pungent, cool, non-toxic.

[Function] It has inhibitory effect on Staphylococcus aureus, streptococcus, Escherichia coli, typhoid bacillus, paratyphoid bacillus, Shigella bacillus, Bacillus anthracis, Bacillus subtilis, acid-fast bacillus and some fungi; The stimulating effect can increase the activity of the reticuloendothelial system; thereby enhancing the body's defense ability and healing process; clinically it can be used for general infections such as upper respiratory tract infection, stomatitis and urinary tract infection.

Sichuan peppercorn:

[meridian distribution of nature and flavor] pungent in taste, warm in nature. It is slightly poisonous. Return spleen, stomach, kidney channel.

[Efficacy] It has the functions of warming the middle, relieving pain, killing insects and relieving itching. Raw Zanthoxylum bungeanum is slightly poisonous, has a strong pungent and warm property, and is good for killing insects and relieving itching when used externally. For scabies, eczema, or itchy skin. Consuming pepper water can remove parasites; it has the effects of invigorating the stomach, warming the middle and dispelling cold, dehumidifying and relieving pain, killing insects and detoxifying, and relieving itching and fishy smell. the

[Pharmacology] Antibacterial test: Zanthoxylum bungeanum has 10 kinds of Gram-positive bacteria, including Bacillus anthracis, hemolytic streptococcus, diphtheria bacillus, pneumococcus pneumococcus, staphylococcus aureus, citrine and white staphylococcus, Bacillus subtilis, and Escherichia coli , Sonnell's dysentery rod flute, Proteus, typhoid and paratyphoid bacillus, Pseudomonas aeruginosa, Vibrio cholerae and other intestinal pathogenic bacteria have obvious inhibitory effect. The 1:4 water infusion also has inhibitory effect on Nocardia asteratus. According to animal experiments, a small amount of continuous use can promote the development of glands related to metabolism, and a large amount can promote the development of glands related to reproduction. This proves the understanding of the ancients "warming the yang and invigorating the kidney".

granulated sugar:

Lukewarm, non-toxic. It mainly nourishes the temper, relieves upset, inability to eat and drink, relieves intestinal pain, pain in the muscles, aphtha, and clears eyes and ears. Jiu Yannian is a god. Shengwudu, Heyuan Valley, and all the mountains and rocks are as white as ointment. the

The original text of "The Classic": Granulated sugar, sweet and flat. Main confidant evil spirit, all convulsions epilepsy, all insufficiency of alleviating the five internal organs, invigorating qi and invigorating the middle, relieving pain. the

Sweet in taste and flat in nature, it belongs to the spleen and lung meridian; it has the effects of moistening the lungs and promoting body fluid, relieving cough, harmonizing the lungs, soothing liver qi, nourishing yin, seasoning, removing bad breath, and detoxifying salt and brine.

Turnip:

[meridian distribution of property and flavor] pungent, bitter, flat. the

[Functions and Indications] Eliminate accumulation and kill insects. For infantile malnutrition, ascariasis, pinworm disease.

peppermint:

[nature and flavor] "Chinese Medical Dictionary": "pungent, cool, non-toxic."

【Function】Aromatic medicine, seasoning medicine and carminative medicine. Function: It can be used on the skin or mucous membrane to produce a cooling sensation to relieve discomfort and pain. The anti-irritant effect causes the trachea to produce new secretions, and makes the thick mucus easy to get rid of, so it has the effects of expectorant and bactericidal.

soybean oil:

[nature and flavor] pungent; sweet; warm [return through] large intestine meridian

【Efficacy classification】moisturizing medicine

[Efficacy] Moisten the intestines and laxative; repel insects and detoxify

[Research] From "Compendium of Materia Medica". the

[Family and Generic Classification] Legumes

【Indications】intestinal worm obstruction; constipation; scabies

Detailed ways:

Embodiment 1, formula:

Betel nut 30g, dry lacquer 30g, Sophora japonica flower 30g, Bean root 30g, Neem leaf 30g, Ghost arrow feather 30g, Crane lice 30g, Predictor 20g, Veratrum 20g, Baibu 20g, Shijunzi 20g, Asafoetida 20g, Lily 20g of dried torreya, 20g of torreya, 10g of Sichuan pepper, 10g of purslane, 10g of pumpkin seeds, 10g of camphor leaves, 10g of wolf bean leaves, 10g of garlic, 1g of light powder, 1g of ecliptic lotus, 1g of pepper, 1g of sugar, and turnip 1g, peppermint oil 1g, soybean oil 1g;

Preparation:

1) Extract, separate, dry, and pulverize the other ingredients except peppermint oil and soybean oil according to the formula ratio;

2) The powder obtained in Preparation Method 1 is mixed with peppermint oil and soybean oil in proportion, mixed evenly, and dried to make tablets, capsules, oral preparations, smears, and sprays.

Test: select SD rats, give different concentrations (18.0, 6.0, 2.0g crude drug/kg) of the Chinese medicine composition preparation of the present invention, gavage once a day, continuous 90 days, each group kills alive 24 hours after the last administration. 1/2 animals (half male and half female), and the remaining 1/2 animals continued to observe for 2 weeks and then killed alive. During the test period, the appearance, general behavior, food intake and body weight of the animals were observed, and hematology (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemistry were performed 90 days after administration and 2 weeks after drug withdrawal. (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology and other indicators. The test results show: the traditional Chinese medicine preparation of the present invention is in high, medium and low dose groups, and the general state of the animals is good, and there is no abnormal change in appearance signs, behavioral activities, food intake and weight gain; The biochemical and urine biochemical examinations were all within the normal range, and there was no significant difference between the groups; no obvious abnormalities were found in the histopathological examination of major organs in each group. The above indicators did not change after 2 weeks of drug withdrawal. This test dosage is respectively 180,60,20 times of the clinical dosage, and according to the test results, the Chinese medicine preparation of the present invention is given in high, medium and low dosages (18.0, 6.0, 2.0g crude drug/kg) for 90 days. There is no obvious effect on rats, no clear toxic target organs and sensitive indicators, and no delayed toxic reactions are observed in the recovery period, suggesting that the dosage safety of the clinical application of the traditional Chinese medicine preparation of the present invention is relatively high.

Clinical statistics: cure rate ≥ 80%, clinical effective rate ≥ 90%.

Embodiment 2, formula:

Betel nut 32g, dry lacquer 32g, Sophora japonica 32g, Bean root 32g, Neem leaf 32g, Ghost arrow feather 32g, Crane lice 32g, Predict 22g, Veratrum 22g, Baibu 22g, Shijunzi 22g, Asafoetida 22g, Lily 22g storage, 22g torreya, 12g Sichuan pepper, 12g purslane, 12g pumpkin seeds, 12g camphor leaves, 12g big-leaved wolf bean leaves, 12g garlic, 2g light powder, 2g eclipta, 2g pepper, 2g sugar, turnip 2g, peppermint oil 2g, soybean oil 2g.

Preparation:

The medicine is mixed, soaked in water for 2 hours, decocted twice, the filtrates are separated, the filtrates of the two times before and after are combined, left to stand for 14 hours, filtered twice, and then the filtrate is heated in vacuum to concentrate the filtrate to a density of 1.22g/ml, and then After spray drying, the traditional Chinese medicine powder can be obtained.

Test: guinea pig skin allergy test and rat rectal administration irritation test of the preparation of the present invention. The results show that: in the skin allergy test, 0.8g (medicine powder)/kg in the high-dose group and 0.1g (medicine powder)/kg in the low-dose group are respectively equivalent to [0.04g (medicine powder)/kg] of clinical pigs, horses, and cattle. 20 times and 2.5 times, through skin administration, no animal is seen to produce allergic reaction; Rectal administration irritation test high dose group 5.0g (medicine powder)/kg, low dose group 3.2g (medicine powder)/kg, are equivalent to respectively 125 and 80 times the clinical dosage of pigs, horses, and cattle. There was no congestion and edema in the rectal mucosa observed within the specified time. There was no significant difference between the histopathological examination and the blank control group, and no obvious irritating reaction was seen. , some of the remaining animals in each group had no obvious abnormal reactions in terms of their general conditions, body weight, respiration, circulation, central nervous system and limb activities.

Clinical statistics: cure rate ≥ 90%, clinical effective rate ≥ 100%.

Embodiment 3, formula:

Betel nut 35g, dry lacquer 35g, Sophora japonica 35g, Shandou root 35g, Neem leaf 35g, Ghost arrow feather 35g, Crane lice 35g, Predict 25g, Veratrum 25g, Baibu 25g, Shijunzi 25g, Asafoetida 25g, Lily 25g storage, 25g torreya, 15g Sichuan pepper, 15g purslane, 15g pumpkin seeds, 15g camphor leaves, 15g big-leaved wolf bean leaves, 15g garlic, 5g light powder, 5g eclipta, 5g pepper, 5g sugar, turnip 5g, peppermint oil 5g, soybean oil 5g.

The preparation method is the same as in Example 1. the

Test: guinea pig skin allergy test and rat rectal administration irritation test of the preparation of the present invention. The results show that: in the skin allergy test, 0.8g (medicine powder)/kg in the high-dose group and 0.1g (medicine powder)/kg in the low-dose group are respectively equivalent to [0.04g (medicine powder)/kg] of clinical pigs, horses, and cattle. 20 times and 2.5 times, through skin administration, no animal is seen to produce allergic reaction; Rectal administration irritation test high dose group 5.0g (medicine powder)/kg, low dose group 3.2g (medicine powder)/kg, are equivalent to respectively 125 and 80 times the amount used in clinical pigs, horses, and cattle. There was no congestion and edema in the rectal mucosa observed within the specified time. There was no significant difference between the histopathological examination and the blank control group, and no obvious irritating reaction was seen. , some of the remaining animals in each group had no obvious abnormal reactions in terms of their general conditions, body weight, respiration, circulation, central nervous system and limb activities.

Clinical statistics: the cure rate is ≥95%, and the clinical effective rate is ≥100%.

Embodiment 4, formula:

Betel nut 38g, dry lacquer 38g, Sophora japonica 38g, Bean root 38g, Neem leaf 38g, Ghost arrow feather 38g, Crane louse 38g, Predict 28g, Veratrum 28g, Baibu 28g, Shijunzi 28g, Asafoetida 28g, Lily 28g storage, 28g torreya, 18g Sichuan pepper, 18g purslane, 18g pumpkin seeds, 18g camphor leaf, 18g big-leaved wolf bean chai leaf, 18g garlic, 8g light powder, 8g eclipta, 8g pepper, 8g sugar, turnip 8g, peppermint oil 8g, soybean oil 8g.

The preparation method is the same as in Example 1. the

Test: the application of mice to carry out acute toxicity experiments shows that: mice are orally administrated with the traditional Chinese medicine preparation of the present invention, under the dose of 488.8g crude drug/kg, the mice have a slight activity reduction after administration, and return to normal in about 1 hour. Continuously observed for 7 days, no animal died, and its general condition, diet, water intake, urination and weight gain were all normal. The experimental results showed that the maximum dosage of the traditional Chinese medicine preparation capsule of the present invention for oral administration of mice was 488.8g Crude drug/kg/d (LD 50 >488.8g crude drug/kg). The daily clinical dosage of the traditional Chinese medicine preparation of the present invention is 0.1 g of crude drug/kg/d; in terms of body weight, the tolerated dose of the traditional Chinese medicine preparation of the present invention in mice is 4888 times that of clinically ill pigs, horses and cattle. It is suggested that the drug has low acute toxicity and is safe for clinical use.

Clinical statistics: cure rate ≥ 80%, clinical effective rate ≥ 90%.

Embodiment 5, formula:

40g betel nut, 40g dried lacquer, 40g Sophora japonica, 40g bean root, 40g neem leaf, 40g ghost arrow feather, 40g crane lice, 30g predictor, 30g veratrum, 30g centipede, 30g Shijunzi, 30g asafoetida, 30g storage, 30g torreya, 20g Sichuan pepper, 20g purslane, 20g pumpkin seeds, 20g camphor leaves, 20g big-leaved wolf bean chai leaves, 20g garlic, 10g light powder, 10g ecliptas, 10g pepper, 10g sugar, turnip 10g, peppermint oil 10g, soybean oil 10;

Preparation:

1) Extract, separate, dry, and pulverize the other ingredients except peppermint oil and soybean oil according to the formula ratio;

2) The powder obtained in Preparation Method 1 is mixed with peppermint oil and soybean oil in proportion, mixed evenly, and dried to make tablets, capsules, oral preparations, smears, and sprays.

Test: select SD rats, give different concentrations (18.0, 6.0, 2.0g crude drug/kg) of the present invention's Chinese medicine preparation, gavage once a day, for 90 consecutive days, kill 1/2 of each group alive 24 hours after the last administration Animals (half male and half female), and the remaining 1/2 animals continued to be observed for 2 weeks before being killed alive. During the test, the appearance, general behavior, food intake and body weight changes of the animals were observed, and hematology (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemistry ( AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology and other indicators inspection. The test results show that: the preparation of the present invention is in high, middle and low dose group animals in good general condition, and there are no abnormal changes in appearance signs, behavioral activities, food intake and body weight growth; Urine biochemical examinations were all within the normal range, and there was no significant difference between the groups; no obvious abnormalities were found in the histopathological examination of major organs in each group. The above indicators did not change after 2 weeks of drug withdrawal. The test dosage is respectively 180, 60, and 20 times of the clinical dosage, and according to the test results, the Chinese medicine preparation of the present invention is administered continuously for 90 days at high, medium and low dosages (18.0, 6.0, 2.0g crude drug/kg). It has no obvious effect on rats, no clear target organs of toxicity and sensitive indicators, and no delayed toxic reaction is observed in the recovery period, suggesting that the dose safety of the clinical application of the traditional Chinese medicine preparation of the present invention is relatively high.

Clinical statistics: cure rate ≥ 80%, clinical effective rate ≥ 90%.

The beneficial effects of the present invention are:

Tests have proved that the combined use of the medicines of the present invention is safe and has no toxic or side effects. It can not only repel nematodes, mites, and protozoa, but also repel various parasites and certain stage larvae in and out of livestock, and can also inhibit the elimination and development of eggs. The preparation of the present invention will not be damaged by gastric acid, directly reaches the intestinal tract, is slowly released and absorbed to act on worm bodies, and has an obvious deworming effect.

Claims (5)

1. Veterinary anthelmintic Chinese medicinal preparation, characterized in that, is made up of the following raw materials in parts by weight: 30-40 parts of betel nut, 30-40 parts of dry paint, 30-40 parts of Sophora japonica, 30-40 parts of mountain bean root, 30-40 parts of neem leaf, 30-40 parts of ghost arrow feather, 30-40 parts of crane lice, 20-30 servings of Chizhizi, 20-30 servings of Veratrum, 20-30 servings of Baibu, 20-30 servings of Shijunzi, 20-30 servings of Ferulicum, 20-30 servings of Chinese Torreya, 20-30 servings of Torreya, Chuanjiao 10-20 parts of purslane, 10-20 parts of purslane, 10-20 parts of pumpkin seeds, 10-20 parts of camphor tree leaves, 10-20 parts of big-leaved wolf bean chai leaves, 10-20 parts of garlic, 1-10 parts of light powder , Eclipta 1-10 parts, Zanthoxylum bungeanum 1-10 parts, sugar 1-10 parts, turnip 1-10 parts, peppermint oil 1-10 parts, soybean oil 1-10 parts. 2. The veterinary anthelmintic Chinese medicine preparation according to claim 1, characterized in that, is made up of the following raw materials in parts by weight: 32-38 parts of betel nut, 32-38 parts of dry paint, 32-38 parts of Sophora japonica, 32-38 parts of mountain bean root, 32-38 parts of neem leaf, 32-38 parts of ghost arrow feather, 32-38 parts of crane lice, 22-28 servings of Zhizhizi, 22-28 servings of Veratrum, 22-28 servings of Baibu, 22-28 servings of Shijunzi, 22-28 servings of Ferulicum, 22-28 servings of Chinese Torreya, 22-28 servings of Torreya, Chuanjiao 12-18 parts, 12-18 parts of purslane, 12-18 parts of pumpkin seeds, 12-18 parts of camphor tree leaves, 12-18 parts of big-leaved wolf bean chai leaves, 12-18 parts of garlic, 2-8 parts of light powder , 2-8 parts of Eclipta, 2-8 parts of Zanthoxylum bungeanum, 2-8 parts of sugar, 2-8 parts of turnip, 2-8 parts of peppermint oil, and 2-8 parts of soybean oil. 3. The veterinary anthelmintic Chinese medicine preparation according to claim 1, characterized in that, it is composed of the following raw materials in parts by weight: 35 parts of betel nut, 35 parts of dried lacquer, 35 parts of Sophora japonica, 35 parts of mountain bean root, 35 parts of neem leaf, 35 parts of ghost arrow feather, 35 parts of crane lice, 25 parts of prophetic seed, 25 parts of veratrum, 25 parts of hundred parts , 25 parts of Gentleman, 25 parts of Ferulicum, 25 parts of 萹节, 25 parts of Torreya japonica, 15 parts of Chuanjiao, 15 parts of purslane, 15 parts of pumpkin seeds, 15 parts of camphor tree leaves, 15 parts of wolfberry leaves, 15 parts of garlic, 5 parts of light powder, 5 parts of eclipse flower, 5 parts of pepper, 5 parts of sugar, 5 parts of turnip, 5 parts of peppermint oil, and 5 parts of soybean oil. 4. The veterinary anthelmintic traditional Chinese medicine preparation according to any one of claims 1-3, characterized in that, the preparation method: Mix the medicines, soak in water for 2 hours, decoct twice, filtrate separately, combine the filtrates before and after the two times, let stand for 14 hours, filter twice, then heat the filtrate in vacuum to concentrate the filtrate to a density of 1.22g/ml, then After spray drying, the traditional Chinese medicine powder can be obtained. 5. The veterinary anthelmintic traditional Chinese medicine preparation according to any one of claims 1-3, characterized in that, the preparation method: 1) Extract, separate, dry, and pulverize other ingredients except peppermint oil and soybean oil according to the formula ratio; 2) The powder obtained in Preparation Method 1 is mixed with peppermint oil and soybean oil in proportion, mixed evenly, and dried to make tablets, capsules, and oral preparations.