CN104815217A

CN104815217A - Pharmaceutical composition for treating pigeon body psoroptic mange and preparation method of pharmaceutical composition

Info

Publication number: CN104815217A
Application number: CN201510249283.8A
Authority: CN
Inventors: 吴海燕; 黄河; 李鑫
Original assignee: Shandong New Hope Liuhe Group Co Ltd
Current assignee: Shandong New Hope Liuhe Group Co Ltd
Priority date: 2015-05-18
Filing date: 2015-05-18
Publication date: 2015-08-05

Abstract

The invention discloses a pharmaceutical composition for treating pigeon body psoroptic mange and a preparation method of the pharmaceutical composition. Raw materials of the pharmaceutical composition for treating the pigeon body psoroptic mange comprise cortex meliae, garlic, ox's thyroid gland, aloe, lilac daphne flower bud, sweet vernal grass, bambusa glaucophylla, polygonum aviculare, fructus evodiae, thelephora vialis, scirpus subcapitatus, lythrum, ailanthus altissima, diuranthera major, lycopodium phlegmaria, red-knees herb, radish leaves, lysimachia foenum-graecum, costustoot, turbinate aster, rhizoma anemarrhenae, rhizoma phragmitis, draba nemorosa, root of Chinese trichosanthes, glabrous greenbrier rhizome, dayflower, medicago lupulina, dandelion, sesbania, japanese violet herb or root, scandent schefflera stem and leaf and edible tulip. The pharmaceutical composition for treating the pigeon body psoroptic mange has the beneficial effects that the pharmaceutical composition has the effects of clearing away heat and toxic materials and expelling parasites and is mainly used for treating pigeon body psoroptic mange of pigeons 2-3 years in age, so that immunity of the pigeons is improved, and disease resistance of the pigeons can alsobe improved; the advantages of strong targeted property, obvious curative effect, difficulty in occurrence, short medication time interval, low medication frequency and no toxic or side effect are realized, and hatchability and laying rate of female pigeons can be well guaranteed.

Description

A kind ofly be used for the treatment of pharmaceutical composition of Columba livia body acaricide and preparation method thereof

Technical field

The present invention relates to veterinary drug technical field, be specifically related to a kind ofly be used for the treatment of pharmaceutical composition of Columba livia body acaricide and preparation method thereof.

Background technology

Columba livia acaricide is the chronic dermatosis by each section mites infest in Columba livia table or epidermis caused by (they are organized with food of sucking blood, sting or feather is made a living).Propagate with the way of contact, the gargalesthesia that Columba livia can be caused violent and various types of scytitis.Columba livia is the resident host of demodicid mite.Below the scale generally parasitizing feather, feather capsule, subcutaneous tissue and lower limb.Depending on kind difference, with suck blood, sting food tissue or feather make a living.Parasitize that the demodicid mite of Columba livia is common red demodicid mite (Dermanyssus gallinae, blood demodicid mite), quill mite, air-sac mite, knemidokoptes mutans, feather mite and body acaricide etc.

Because the kind of demodicid mite is different, its parasitic site and caused clinical symptoms are not identical yet.

Red demodicid mite (blood demodicid mite) is that one is sucked blood demodicid mite, night Su Ge, daytime flees from.It can encroach on squab and young Columba livia, causes dysphoria at night, causes anemia and growth promoter slowly, make the mucosa of Columba livia in yellow, and the mucosa of normal Columba livia is cherry.At warm regional especially severe.It is also the major transmitter that pigeon variola and blood become protozoon.

Quill mite main parasitic is in the pteryla portion of wing plumage and tail feathers.Have slight infringement to Columba livia, newborn feather bud during main infringement moult, affects feather growth.

Air-sac mite colonizes in air bag and respiratory tract, in fine, bright grains of sand shape, colonizes in air bag easily out in the cold, is also full of the liquid of thickness, causes airsacculitis, also there will be inappetence, pant in air bag, frequent sneeze, and it is not busy difficult to breathe.

Knemidokoptes mutans colonizes in Columba livia leg without in the tissue under hair place foot wei shanny, makes a living with body fluid to organize, and makes chafing and thickens, and forms the incrustation of calciform squamous, causes pigeon to walk difficult.

Under feather mite colonizes in the wing of Columba livia and main tail feather, sting the juice of food feather capsule, make pigeon wing plumage and main tail feather become frangible and break, make feather seem sparse.

Body acaricide parasitizes in the skin of the abdominal part of pigeon, back, lower limb and afterbody, causes skin to produce like crust scabies shape erythra.Sick Columba livia has obvious gargalesthesia, and shed feathers, health is weak, female Columba livia unrelieved feeling hatching, egg drop reduction.

At present, western medical treatment Columba livia acaricide: two chlorobenzene oxygen dimethrin: with the content breading of 0.125%-0.5%, spreading or sprinkling Columba livia, henroost, nest, Columba livia case, wall and ground etc.But, to take care during use, prevent excessive and cause poisoning.With 0.03% coumafos aqueous emulsion, 0.3% killing logvalue solution, avilamycin (Ivermectin HCL), by every kg body weight subcutaneous injection 0.2 milligram.Embrocate affected part etc. with 0.1% binapacryl solution, or embrocate affected part with 20% sulfur ointment or 2% carbolic acid Ointment, 3 days 1 time, be used in conjunction 3 ~ 5 days.Control Columba livia acaricide mainly strengthens feeding and management, and environmental enhancement is sterilized.Skin finds after wound, and depilation place can smear sulfur ointment, and pigeon can oral or injection ivermectin or avilamycin.But, have to pass through repeatedly medication during treatment, and each administration time interval is long.

At present, all limited to the scheme of western medical treatment Columba livia acaricide and prevention Columba livia acaricide, medicine, do not reach desirable therapeutic effect, and the more high defect for the treatment of cost.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition being used for the treatment of Columba livia body acaricide, this pharmaceutical composition has effect of heat-clearing and toxic substances removing and anthelmintic, cure mainly 2-3 Columba livia body acaricide in age in year, the immunity of Columba livia can be improved, the resistance against diseases of pigeon can be improved again, treatment 2-3 year age Columba livia body acaricide in, by force pointed, evident in efficacy, not easily recur, shorten administration time interval and times for spraying, and the advantage had no side effect, in addition, well can also ensure the incubation rate of female Columba livia and improve the advantage of laying rate.

In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of Columba livia body acaricide, described pharmaceutical composition comprises following raw medicinal material: Cortex Meliae, Bulbus Allii, Thyreoid Bovis seu Bubali, Aloe, Flos Genkwa, Folium sidae alnifoliae, le bamboo, Herba Polygoni Avicularis, Fructus Evodiae, lotus throne lead fungi, Long Xuguan, thousand bend grass, Cortex Ailanthi, Radix diurantherae majoris, LONGHU, Herba polygoni hydropiperis, Folium Raphani, Herba Lysimachiae foenum-graeci, the Radix Aucklandiae, top sieve Radix Asteris, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Semen Lepidii, Radix Trichosanthis, Rhizoma Smilacis Glabrae, Herba Commelinae, shamrock, Herba Taraxaci, sesbania, Herba Violae japonicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) and Pseudobulbus Cremastrae Seu Pleiones.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 10-22 weight portion, Bulbus Allii 7-15 weight portion, Thyreoid Bovis seu Bubali 5-10 weight portion, Aloe 10-20 weight portion, Flos Genkwa 3-5 weight portion, Folium sidae alnifoliae 11-21 weight portion, le bamboo 12-24 weight portion, Herba Polygoni Avicularis 8-16 weight portion, Fructus Evodiae 10-26 weight portion, lotus throne lead fungi 14-26 weight portion, dragon palpus tabernaemontanus bulrush 12-22 weight portion, thousand bend careless 15-35 weight portion, Cortex Ailanthi 10-20 weight portion, Radix diurantherae majoris 12-26 weight portion, the sub-15-35 weight portion of LONGHU, Herba polygoni hydropiperis 14-32 weight portion, Folium Raphani 10-20 weight portion, Herba Lysimachiae foenum-graeci 12-28 weight portion, Radix Aucklandiae 11-23 weight portion, top sieve Radix Asteris 14-26 weight portion, Rhizoma Anemarrhenae 12-31 weight portion, Rhizoma Phragmitis 10-22 weight portion, Semen Lepidii 7-14 weight portion, Radix Trichosanthis 15-35 weight portion, Rhizoma Smilacis Glabrae 12-28 weight portion, Herba Commelinae 14-36 weight portion, shamrock 15-30 weight portion, Herba Taraxaci 12-22 weight portion, sesbania 10-30 weight portion, Herba Violae japonicae 12-30 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 13-25 weight portion and Pseudobulbus Cremastrae Seu Pleiones 10-20 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 14 weight portion, Bulbus Allii 8 weight portion, Thyreoid Bovis seu Bubali 7 weight portion, Aloe 18 weight portion, Flos Genkwa 3 weight portion, Folium sidae alnifoliae 14 weight portion, le bamboo 22 weight portion, Herba Polygoni Avicularis 14 weight portion, Fructus Evodiae 22 weight portion, lotus throne lead fungi 19 weight portion, dragon palpus tabernaemontanus bulrush 13 weight portion, thousand bend careless 32 weight portions, Cortex Ailanthi 15 weight portion, Radix diurantherae majoris 25 weight portion, LONGHU 35 weight portions, Herba polygoni hydropiperis 17 weight portion, Folium Raphani 12 weight portion, Herba Lysimachiae foenum-graeci 24 weight portion, the Radix Aucklandiae 22 weight portion, top sieve Radix Asteris 16 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Rhizoma Phragmitis 16 weight portion, Semen Lepidii 10 weight portion, Radix Trichosanthis 34 weight portion, Rhizoma Smilacis Glabrae 24 weight portion, Herba Commelinae 32 weight portion, shamrock 28 weight portion, Herba Taraxaci 16 weight portion, sesbania 12 weight portion, Herba Violae japonicae 25 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 22 weight portion and Pseudobulbus Cremastrae Seu Pleiones 15 weight portion.

Described pharmaceutical composition also comprises Rhizoma begoniae pedatifidae, Yichang Caulis Viburni Dilatati, Fructus elaeagni glabrae, Herba Hyperici perforati, Liquor chrysanthemi Distillata and Herba pyrrosiae mollis.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 10-22 weight portion, Bulbus Allii 7-15 weight portion, Thyreoid Bovis seu Bubali 5-10 weight portion, Aloe 10-20 weight portion, Flos Genkwa 3-5 weight portion, Folium sidae alnifoliae 11-21 weight portion, le bamboo 12-24 weight portion, Herba Polygoni Avicularis 8-16 weight portion, Fructus Evodiae 10-26 weight portion, lotus throne lead fungi 14-26 weight portion, dragon palpus tabernaemontanus bulrush 12-22 weight portion, thousand bend careless 15-35 weight portion, Cortex Ailanthi 10-20 weight portion, Radix diurantherae majoris 12-26 weight portion, the sub-15-35 weight portion of LONGHU, Herba polygoni hydropiperis 14-32 weight portion, Folium Raphani 10-20 weight portion, Herba Lysimachiae foenum-graeci 12-28 weight portion, Radix Aucklandiae 11-23 weight portion, top sieve Radix Asteris 14-26 weight portion, Rhizoma Anemarrhenae 12-31 weight portion, Rhizoma Phragmitis 10-22 weight portion, Semen Lepidii 7-14 weight portion, Radix Trichosanthis 15-35 weight portion, Rhizoma Smilacis Glabrae 12-28 weight portion, Herba Commelinae 14-36 weight portion, shamrock 15-30 weight portion, Herba Taraxaci 12-22 weight portion, sesbania 10-30 weight portion, Herba Violae japonicae 12-30 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 13-25 weight portion, Pseudobulbus Cremastrae Seu Pleiones 10-20 weight portion, Rhizoma begoniae pedatifidae 15-30 weight portion, Yichang Caulis Viburni Dilatati 10-22 weight portion, Fructus elaeagni glabrae 9-18 weight portion, Herba Hyperici perforati 14-26 weight portion, Liquor chrysanthemi Distillata 15-35 weight portion and Herba pyrrosiae mollis 12-28 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 14 weight portion, Bulbus Allii 8 weight portion, Thyreoid Bovis seu Bubali 7 weight portion, Aloe 18 weight portion, Flos Genkwa 3 weight portion, Folium sidae alnifoliae 14 weight portion, le bamboo 22 weight portion, Herba Polygoni Avicularis 14 weight portion, Fructus Evodiae 22 weight portion, lotus throne lead fungi 19 weight portion, dragon palpus tabernaemontanus bulrush 13 weight portion, thousand bend careless 32 weight portions, Cortex Ailanthi 15 weight portion, Radix diurantherae majoris 25 weight portion, LONGHU 35 weight portions, Herba polygoni hydropiperis 17 weight portion, Folium Raphani 12 weight portion, Herba Lysimachiae foenum-graeci 24 weight portion, the Radix Aucklandiae 22 weight portion, top sieve Radix Asteris 16 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Rhizoma Phragmitis 16 weight portion, Semen Lepidii 10 weight portion, Radix Trichosanthis 34 weight portion, Rhizoma Smilacis Glabrae 24 weight portion, Herba Commelinae 32 weight portion, shamrock 28 weight portion, Herba Taraxaci 16 weight portion, sesbania 12 weight portion, Herba Violae japonicae 25 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 22 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15 weight portion, Rhizoma begoniae pedatifidae 30 weight portion, Yichang Caulis Viburni Dilatati 20 weight portion, Fructus elaeagni glabrae 9 weight portion, Herba Hyperici perforati 14 weight portion, Liquor chrysanthemi Distillata 35 weight portion and Herba pyrrosiae mollis 22 weight portion.

The dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, Semen Lepidii, Radix Trichosanthis, Rhizoma Smilacis Glabrae, Herba Commelinae, shamrock, Herba Taraxaci, sesbania, Herba Violae japonicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) and Pseudobulbus Cremastrae Seu Pleiones are mixed in described ratio, with being the dissolve with ethanol of 85% ~ 95% relative to the determining alcohol of 3 ~ 5 times of mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Rhizoma begoniae pedatifidae, Yichang Caulis Viburni Dilatati, Fructus elaeagni glabrae, Herba Hyperici perforati, Liquor chrysanthemi Distillata and Herba pyrrosiae mollis are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The invention has the beneficial effects as follows: this pharmaceutical composition has effect of heat-clearing and toxic substances removing and anthelmintic, cure mainly 2-3 Columba livia body acaricide in age in year, the immunity of Columba livia can be improved, the resistance against diseases of pigeon can be improved again, treatment 2-3 year age Columba livia body acaricide in, by force pointed, evident in efficacy, not easily recur, shorten administration time interval and times for spraying, and the advantage had no side effect, in addition, incubation rate and the laying rate of female Columba livia well can also be ensured.

Detailed description of the invention

Pharmaceutical composition of the present invention follows heat-clearing and toxic substances removing, the Therapeutic Principle of anthelmintic, there is provided a kind of be used for the treatment for the treatment of 2-3 year age Columba livia pharmaceutical composition, comprise following raw medicinal material: Cortex Meliae, Bulbus Allii, Thyreoid Bovis seu Bubali, Aloe, Flos Genkwa, Folium sidae alnifoliae, le bamboo, Herba Polygoni Avicularis, Fructus Evodiae, lotus throne lead fungi, dragon palpus tabernaemontanus bulrush, thousand bend grass, Cortex Ailanthi, Radix diurantherae majoris, LONGHU, Herba polygoni hydropiperis, Folium Raphani, Herba Lysimachiae foenum-graeci, the Radix Aucklandiae, top sieve Radix Asteris, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Semen Lepidii, Radix Trichosanthis, Rhizoma Smilacis Glabrae, Herba Commelinae, shamrock, Herba Taraxaci, sesbania, Herba Violae japonicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Pseudobulbus Cremastrae Seu Pleiones, Rhizoma begoniae pedatifidae, Yichang Caulis Viburni Dilatati, Fructus elaeagni glabrae, Herba Hyperici perforati, Liquor chrysanthemi Distillata and Herba pyrrosiae mollis.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Herba Violae japonicae: bitter, micro-pungent, cold." Zhejiang conventional medical herbs among the people ": " heat clearing away, detumescence, removing toxic substances." heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For acute conjunctivitis, pharyngolaryngitis, acute icterohepatitis, mastitis, carbuncle furuncle and phyma poison, suppurative osteomyelitis, venom.

Pseudobulbus Cremastrae Seu Pleiones: bitter, micro-pungent, cool.Dispersing swelling and dissipating binds, reduces phlegm, heat-clearing and toxic substances removing.Control carbuncle furuncle and phyma, laryngopharynx swelling and pain, sore throat, scrofula.Compendium of Material Medica: " main furuncle swells, counteracting toxic substances broken skin.Separate all poison, snakeworm, mad dog wound.", carbuncle furunculosis, scrofula swollen to acute mastitis go through tuberculosis, for oral administration, external application, all can apply.

Cortex Meliae: " Japan hanako materia medica ": " bitter, micro-poison.Treatment wind heat poison, rubella, herpes simplex mange, children's's high fever, and decoct soup and embathe." Jing-Yue Complete Works: " the large hardship of chinaberry root taste.Kill parasites, outstanding kind in ascarid.Profit large intestine, controls urticaria pyretic toxicity malignant boil.Bitters is very good with painting mange." contained Melia azedarach L. have and drives ascarid effect in the root bark of Melia azedarach L. or dried bark.

Bulbus Allii: warm in nature, acrid in the mouth is put down; Enter spleen, stomach, lung meridian, supplement to the Herbal: " the just unfavorable order of food, polyphagia is bright.Food of a specified duration makes us serum, makes hair white ".Have that warming middle-JIAO helps digestion, the stagnant gas of row, warming the spleen and stomach, removing food stagnancy, removing toxic substances, parasite killing effect, cure mainly eating accumulation, coldness and pain in the epigastrium, edema distension, have loose bowels, dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea skin ulcer, snake bite and insect sting and the card such as ancylostome, pinworm.Meanwhile, Bulbus Allii also has certain effect to reduction hypertension.As long as keep blood normal, be just not easy to suffer from the diseases such as hypertension, heart disease, cerebral hemorrhage.

Aloe: bitter in the mouth is cold in nature, removing heat from the liver, relieving constipation, parasite killing; In addition for headache, constipation, pediatric epilepsy scared, infantile malnutrition infections furuncle and phyma, burn and scald, tinea skin ulcer, hemorrhoid, atrophic rhinitis, scrofula, hepatitis, Biliary Calculi, exudative dermatitis etc.

Flos Genkwa: bitter, acrid, cold is poisonous; Return lung, spleen, kidney channel." property of medicine opinion ": " control trusted subordinate's distension, anhydrate gas, and sharp the five internal organs cold-phlegm, tears saliva is as glue person.Main promoting blood circulation, control malignant boil migratory arthralgia and wet, all malicious wind, extremity contraction is anxious, can not go step, can removing water retention by purgation swelling expire." " herbal classic ": " main cough with dyspnea, laryngeal stridor is breathed heavily, and pharyngeal swelling is losed heart, terrible malaria, hernia abdominal mass, carbuncle." parasite killing detoxifies for removing fluid-retention by purgation, expelling phlegm for arresting cough.Cure mainly edema tympanites, the phlegm retention hypochondriac lump, hypochondriac pain of breathing with cough, carbuncle furuncle scabies.

Herba Polygoni Avicularis: bitter, cold; Enter urinary bladder channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " diuresis.Control five types of stranguria nebulousurine, pyretic stranguria, stasis of blood essence is puckery closes the border key, and controls married woman's stagnation of QI, damp and hot in stomach, or the disease of leucorrhea." Compendium of Material Medica: " control cholera, jaundice, diuresis." diuresis, heat clearing away, parasite killing.Cure mainly and control pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea, ascarid, infantile malnutrition, hemorrhoid swell, eczema.

Fructus Evodiae: come from " herbal classic ": " main warming the middle warmer and descending qi, pain relieving, cough with dyspnea cold and heat, dehumidifying, arthralgia due to stagnation of blood, by ailment said due to cold or exposure, loosing the interspaces of skin and muscles." Compendium of Material Medica: " dissipating depression of QIization is stagnant, controls acid regurgitation, and cloudy sputum of fainting is had a headache, insidious stomachache, hernia dysentery, mouthpiece's aphtha." its bitter in the mouth hot in nature trembles with fear, and has the merit of heat radiation pain relieving, stopping nausea and vomiting by lowering the adverse flow of QI, is used for the treatment of that liver insufficiency of stomach is trembled with fear, the disease such as headache caused by cloudy turbid superinverse or stomach wrist pain.Can warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, and stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.Research shows: evodine contained in Fructus Evodiae is amaroid, and have bitterness digestion promoting function, the volatile oil contained by it has again fragrant digestion promoting function. the methanolic extract of Fructus Evodiae, has the effect of Chinese People's Anti-Japanese Military and Political College's Mus water logging stress ulcer; Water decoction also has anti-salt acidic gastric ulcer and indometacin adds alcohol repellency gastric ulcer effect, water logging irritability and ligation pylorus ulcer is had to the tendency suppressing to be formed.

Cortex Ailanthi: source: come from " property of medicine opinion ".Nature and flavor: bitter; Puckery; Cold.Gui Jing: stomach; Large intestine; The heart; Liver; Spleen; Lung meridian.Cure mainly: heat clearing and damp drying; Astringing intestine to stop diarrhea; Hemostasis; Leukorrhagia stopping; Parasite killing.Master has loose bowels; Dysentery; Have blood in stool; Metrorrhagia; Bleeding hemorrhoids; Leukorrhagia; Ascariasis; Skin ulcer tinea.

The Radix Aucklandiae: pungent is bitter, warm in nature; Return spleen, large intestine, tri-jiao channel.Compendium of Material Medica cloud: " Radix Aucklandiae is the medicine of three burnt edema caused by disorder of QI, can be elevated all gas.All gas Fen are strongly fragrant, all belong to lung, therefore the person of QI stagnating in upper-JIAO use, be golden Yu Ze let out also; Middle gas is not transported, and all belongs to spleen, therefore the person that QI stagnating in middle-JIAO is suitable, taste happiness fragrance is also; QI stagnation of the large intestine then weighs afterwards, and bladder gas does not change then infirmity pouring, and hepatic depression is then pain, therefore stagnation of QI in lower-JIAO person should it, the person that is plug logical also ".Effect: circulation of qi promoting, pain relieving, spleen invigorating, helps digestion.Cure mainly: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot, and abdominal distention, tells and have loose bowels, heavy after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.The Radix Aucklandiae pungent temperature perfume is loose, can rise and can fall, and leads to the gas of reason three Jiao, especially the gas of benefaction gastrointestinal and pain relieving, and have the merit of strengthening the spleen to promote digestion concurrently, caused by all taste QI stagnation of the large intestine, all cards are conventional product.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire,

Rhizoma Phragmitis: sweet, cold; Return lung meridian, stomach warp.Clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis is used for gastropyretic vomiting.Rhizoma Phragmitis can clearing heat to ease the stomach preventing or arresting vomiting, does not grow again greasyly to hinder stomach, therefore to vomit the key medicine of the sound of vomiting for controlling gastric heat.

Radix Trichosanthis: sweet, micro-hardship, is slightly cold; Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis." book on Chinese herbal medicine justice ": " medicine so-called Radix Trichosanthis person wantonly, namely cuts into slices with it with the root that withers, have the name of powder, real without powder.It smashes the method for thin clear powder." " book on Chinese herbal medicine is looked for the truth ": " and Radix Trichosanthis, than Fructus Trichosanthis, its property is slightly flat, seemingly do not wither impatient compel, and have push away wall fall wall merit also.There is speech regulating the spleen and stomach absolutely continuous to " warp ", say like anon-normal, but its evanescence of heat of cloud is from the meaning of peace." for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.Deficiency and coldness of spleen and stomach stool lingering diarrhea person avoids clothes.Should not with Aconitum medical material with using.

Herba Commelinae: sweet, cold, light; Enter the heart, all warps of liver,spleen,kidney, intestine and small intestine.Supplement to the Herbal: " fourth swells, and meat disease is not smooth, infantile erysipelas, mad epilepsy of generating heat, large abdomen feeling of fullness, body face edema due to disorder of QI, and hematodiarrhoea, dog stings Serpentis, the poison such as carbuncle for main cold and heat subtertian malaria, phlegm retention." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " invigorating QI and blood is treated married woman leucorrhea, redly to be collapsed, tissue regeneration promoting blood, only hematuria, epistaxis blood, stranguria with blood." for fever caused by exogenous pathogens, or febrile disease heating is not moved back, or laryngopharynx swelling and pain, and the disease such as carbuncle skin infection.For dysuria, edema, or wet into diseases such as bet bladder, the puckery pains of dribbling urination.The water logging agent of congener stem and leaf or decoct can excited uterus, vasoconstrictive, and can clotting time be shortened.

Fructus Arctii: nature and flavor: pungent, bitter, cold.Gui Jing: attach to the lung and stomach meridians.Cure mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.

Thyreoid Bovis seu Bubali: source: come from Compendium of Material Medica.Nature and flavor: sweet in the mouth; Warm in nature.Gui Jing: lung; Liver Channel.Cure mainly: sore-throat relieving disappears wart.Main sore throat; Goiter due to disorder of QI.

Folium sidae alnifoliae: source: " Guangxi Chinese herbal medicine ".Nature and flavor: taste is micro-sour and astringent, cool in nature, nontoxic.Cure mainly: heat clearing away is drawn out pus by applying a plaster to the affected part.Control furuncle, honeybee Eriocheir sinensis wound.

Herba Taraxaci: nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp.Cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Le bamboo: nature and flavor: Folium Bambusae: sweet is cool.Cure mainly: clearing away heat and promoting diuresis, eliminating pathogenic heat from blood to cure dysentery, clearing away heat and promoting production of body fluid.

Lotus throne lead fungi: source: Mycophyta Basidiomycetes Aphyllophorales lead fungi section lead fungi Thelephora vialis Schw., is used as medicine with sporophore.Nature and flavor: sweet, flat.Cure mainly: wind-evil dispelling and cold-evil expelling, relaxing muscles and tendons and activating QI and blood in the collateral.

Dragon palpus tabernaemontanus bulrush: nature and flavor: light, cold.Cure mainly: inducing diuresis for treating stranguria syndrome, heat clearing and tranquillizing.Cure mainly urinary tract infection, diabetes, insomnia, conjunctival congestion and swelling pain.

Radix diurantherae majoris: nature and flavor: sweet is flat.Cure mainly: antiinflammatory, hemostasis.Cure mainly traumatic hemorrhage.

LONGHU: nature and flavor: bitter, cool.Cure mainly: loose wind and blood, reducing swelling and alleviating pain.For traumatic injury, rheumatalgia.

Herba polygoni hydropiperis: source: Polygonaceae arsesmart Polygonum flaccidum Meism and Herba Polygoni hydropiperis P. hydropiper L, is used as medicine with herb or root, leaf.The herb four seasons can adopt, and root and leaf can be adopted at any time, dry.Nature and flavor: pungent, temperature.Cure mainly: expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching.For dysentery, gastroenteritis, diarrhoea, rheumatic arthritis, treating swelling and pain by traumatic injury, dysfunctional uterine hemorrhage; Venom is controlled in external, skin eczema.

Folium Raphani: cure mainly: help digestion and quench the thirst, thermal detoxification of dispelling.Cure mainly fullness in the chest vexed, two sides of body are done swollen, and eliminate indigestion is stagnant, alcoholic intoxication.

Herba Lysimachiae foenum-graeci: nature and flavor: sweet, light is flat.Cure mainly: heat clearing away, circulation of qi promoting, pain relieving, drive ascarid.For headache due to common cold, toothache, laryngopharynx swelling and pain, fullness in the chest abdominal distention, ascariasis.

Top sieve Radix Asteris: nature and flavor: micro-hardship is cool.Cure mainly: heat-clearing and toxic substances removing, spleen invigorating, dysentery relieving.Cure mainly acute mastitis, acute tonsillitis, infantile malnutrition, dyspepsia, dysentery, also can be used for anti-curing cold.

Semen Lepidii: nature and flavor: pungent, bitter, cold.Cure mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.

Rhizoma Smilacis Glabrae: nature and flavor: sweet, light, flat.Cure mainly: heat-clearing and toxic substances removing, dampness removing.Cure mainly leptospirosis, syphilis, rheumatic arthritis, carbuncle furuncle and phyma poison, eczema, dermatitis, hydrargyrum powder, Vermilion chronic poisoning.

Shamrock: nature and flavor: sweet, micro-puckery, flat.Cure mainly: clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, relaxing muscles and tendons and activating QI and blood in the collateral.For icterohepatitis, have blood in stool, bleeding hemorrhoids, leukemia, sciatica, rheumatic ostalgia, lumbar muscle strain.Venom is controlled in external.

Sesbania: nature and flavor: pungent, bitter, flat.Cure mainly: antiinflammatory, pain relieving.Cure mainly breast abdomen scorching, high heat, joint contusion, arthralgia.

Thousand bend grass: nature and flavor: bitter, cool.Cure mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For enteritis, dysentery, has blood in stool; Traumatic hemorrhage is controlled in external.

Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): source: Guangzhou army " conventional Chinese herbal medicine handbook ".Nature and flavor: micro-hardship, temperature.1. " Guangxi Chinese herbal medicine ": " warm in nature, acrid in the mouth." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " is bitter sweet, temperature." cure mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens arthralgia pain, stomachache, injury and bone fracture, traumatic hemorrhage." the practical Chinese herbal medicine in Guangxi newly selects ": " promoting the circulation of QI to relieve pain, promoting blood circulation and detumescence, strengthening bone and muscle.Control acute rheumatic arthritis, stomachache, fracture, bruise, lumbago and skelalgia, paralysis."

Rhizoma begoniae pedatifidae: nature and flavor: bitter, cold.Cure mainly: heat-clearing and toxic substances removing, eliminating dampness and promoting diuresis.Root: for bacillary dysentery, acute enteritis, jaundice, ascites, acute conjunctivitis.

Yichang Caulis Viburni Dilatati: nature and flavor: puckery is flat.Cure mainly: heat clearing away, dispel the wind, dehumidifying, antipruritic.

Fructus elaeagni glabrae: nature and flavor: acid is flat.Cure mainly: leaf: antiasthmatic-antitussive.Really: astringing to arrest diarrhea.Root: relieving stranguria by diuresis, dissipating blood stasis for subsidence of swelling.

Herba Hyperici perforati: source: " Nanjing medicinal herbs among the people ".Nature and flavor: 1. " Traditional Chinese Medicine in Sichuan will ": " property is put down, and puckery is nontoxic." 2. " Guizhou medical herbs ": " property is put down, the micro-hardship of acrid in the mouth." cure mainly: heat-clearing and toxic substances removing, astringing to arrest bleeding, dampness removing.Control spitting of blood, spit blood, discharging fresh blood stool, traumatic hemorrhage, rheumatic ostalgia, the raw skin ulcer of mouth and nose, toxic swelling, burn.

Liquor chrysanthemi Distillata: source: " detailed outline is picked up any lost article from the road ".Nature and flavor: " Chinese medicine voluminous dictionary ": " sweetness and bitterness: be slightly cold, nontoxic." curing mainly: 1. " detailed outline is picked up any lost article from the road ": " clear away heart-fire improving eyesight, removes phlegm-accumulating vertigo."

Herba pyrrosiae mollis: source: " mount emei medicine is planted ".Cure mainly: control stranguria, traumatic hemorrhage.1. " mount emei medicine is planted ": " and with flour, apply and control edge of a knife wound." 2. " register planted by Guangxi medicine ": " is pleasant, diuresis."

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

Embodiments provide a kind of pharmaceutical composition being used for the treatment of Columba livia body acaricide, be made up of the raw medicinal material of following parts by weight: Cortex Meliae 14 weight portion, Bulbus Allii 8 weight portion, Thyreoid Bovis seu Bubali 7 weight portion, Aloe 18 weight portion, Flos Genkwa 3 weight portion, Folium sidae alnifoliae 14 weight portion, le bamboo 22 weight portion, Herba Polygoni Avicularis 14 weight portion, Fructus Evodiae 22 weight portion, lotus throne lead fungi 19 weight portion, dragon palpus tabernaemontanus bulrush 13 weight portion, thousand bend careless 32 weight portions, Cortex Ailanthi 15 weight portion, Radix diurantherae majoris 25 weight portion, LONGHU 35 weight portions, Herba polygoni hydropiperis 17 weight portion, Folium Raphani 12 weight portion, Herba Lysimachiae foenum-graeci 24 weight portion, the Radix Aucklandiae 22 weight portion, top sieve Radix Asteris 16 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Rhizoma Phragmitis 16 weight portion, Semen Lepidii 10 weight portion, Radix Trichosanthis 34 weight portion, Rhizoma Smilacis Glabrae 24 weight portion, Herba Commelinae 32 weight portion, shamrock 28 weight portion, Herba Taraxaci 16 weight portion, sesbania 12 weight portion, Herba Violae japonicae 25 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 22 weight portion and Pseudobulbus Cremastrae Seu Pleiones 15 weight portion,

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.7 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 32 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 0.7 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 pharmaceutical composition 2

Embodiments provide a kind of pharmaceutical composition being used for the treatment of Columba livia body acaricide, be made up of the raw medicinal material of following parts by weight: Cortex Meliae 14 weight portion, Bulbus Allii 8 weight portion, Thyreoid Bovis seu Bubali 7 weight portion, Aloe 18 weight portion, Flos Genkwa 3 weight portion, Folium sidae alnifoliae 14 weight portion, le bamboo 22 weight portion, Herba Polygoni Avicularis 14 weight portion, Fructus Evodiae 22 weight portion, lotus throne lead fungi 19 weight portion, dragon palpus tabernaemontanus bulrush 13 weight portion, thousand bend careless 32 weight portions, Cortex Ailanthi 15 weight portion, Radix diurantherae majoris 25 weight portion, LONGHU 35 weight portions, Herba polygoni hydropiperis 17 weight portion, Folium Raphani 12 weight portion, Herba Lysimachiae foenum-graeci 24 weight portion, the Radix Aucklandiae 22 weight portion, top sieve Radix Asteris 16 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Rhizoma Phragmitis 16 weight portion, Semen Lepidii 10 weight portion, Radix Trichosanthis 34 weight portion, Rhizoma Smilacis Glabrae 24 weight portion, Herba Commelinae 32 weight portion, shamrock 28 weight portion, Herba Taraxaci 16 weight portion, sesbania 12 weight portion, Herba Violae japonicae 25 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 22 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15 weight portion, Rhizoma begoniae pedatifidae 30 weight portion, Yichang Caulis Viburni Dilatati 20 weight portion, Fructus elaeagni glabrae 9 weight portion, Herba Hyperici perforati 14 weight portion, Liquor chrysanthemi Distillata 35 weight portion and Herba pyrrosiae mollis 22 weight portion,

The first step, Semen Lepidii, Radix Trichosanthis, Rhizoma Smilacis Glabrae, Herba Commelinae, shamrock, Herba Taraxaci, sesbania, Herba Violae japonicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) and Pseudobulbus Cremastrae Seu Pleiones are mixed in described ratio, with being the dissolve with ethanol of 90% relative to the determining alcohol of 4 times of mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Rhizoma begoniae pedatifidae, Yichang Caulis Viburni Dilatati, Fructus elaeagni glabrae, Herba Hyperici perforati, Liquor chrysanthemi Distillata and Herba pyrrosiae mollis are mixed in described ratio, add the ethanol of the determining alcohol 85% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.21, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 4 hours, filters; By filtering residue again with the water dissolution of 2 times relative to the mixture quality obtained, again heat decoction 2 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 100 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The toxicity test of pharmaceutical composition:

1, trial drug

Choose Cortex Meliae 14g, Bulbus Allii 8g, Thyreoid Bovis seu Bubali 7g, Aloe 18g, Flos Genkwa 3g, Folium sidae alnifoliae 14g, le bamboo 22g, Herba Polygoni Avicularis 14g, Fructus Evodiae 22g, lotus throne lead fungi 19g, dragon palpus tabernaemontanus bulrush 13g, thousand bend careless 32g, Cortex Ailanthi 15g, Radix diurantherae majoris 25g, the sub-35g of LONGHU, Herba polygoni hydropiperis 17g, Folium Raphani 12g, Herba Lysimachiae foenum-graeci 24g, Radix Aucklandiae 22g, top sieve Radix Asteris 16g, Rhizoma Anemarrhenae 30g, Rhizoma Phragmitis 16g, Semen Lepidii 10g, Radix Trichosanthis 34g, Rhizoma Smilacis Glabrae 24g, Herba Commelinae 32g, shamrock 28g, Herba Taraxaci 16g, sesbania 12g, Herba Violae japonicae 25g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 22g and Pseudobulbus Cremastrae Seu Pleiones 15 g mixes, be ground into powder, added by acquisition powder in 1200g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue, again add in 1200g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate, merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 2g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Contrast test:

Gaotang County, Liaocheng of Shandong Province Columba livia plant, in by the end of December, 2012, find nearly 400 2-3 year age Columba livia, female, male ratio is 7:1, at the abdominal part of Columba livia, back, in the skin of lower limb and afterbody, there is seemingly crust scabies shape erythra in various degree, sick Columba livia has obvious gargalesthesia, shed feathers, health is weak, female Columba livia unrelieved feeling hatching, the symptoms such as egg drop reduction, even there are the phenomena of mortality, dead Columba livia is dissected, visible abdominal part under the microscope, back, polypide subcircular and ellipse is had in the skin of lower limb and afterbody, the back side is swelled, milky white and light yellow, female demodicid mite size is 0.3 ~ 0.5 × 0.25 ~ 0.4mm, male demodicid mite size is 0.2 ~ 0.3 × 0.15 ~ 0.2mm.Gnathosoma is short and small, is positioned at front end, and chelicera is as tong-like, and there is little tooth at tip, has antenna and mouth to stretch out external.Columba livia body acaricide is diagnosed as with analysing according to above-mentioned epidemiology.

Choose the ill Columba livia 240 that 2-3 makes a definite diagnosis age in year, female, male ratio is 7:1, and 240 ill Columba livias are divided into three groups at random, is respectively embodiment group 1, embodiment group 2 and matched group, the ill Columba livia of three groups all without significant difference, has comparability in body weight, the state of an illness etc.Embodiment group 1, embodiment group 2 and matched group use the powder of the injectable powder of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively; Wherein, injectable powder adopts subcutaneous injection, each 2g, once a day, and injection 6 days continuously; The using method of powder is mixed in conventional feed by powder according to the part by weight of 0.3g:40g, feeds continuously 6 days; Conventional medicament is subcutaneous injection 0.03% coumafos aqueous emulsion, 0.3% killing logvalue solution, avilamycin (Ivermectin HCL), by every kg body weight subcutaneous injection 0.2 milligram, and continuous use 6 days, conventional feed of simultaneously feeding.Experimental period is 6 days, take each group of ill Columba livia body weight respectively before and after experiment, period records the incubation rate of the recovery from illness number of ill Columba livia, cure rate situation and female Columba livia, and the time of recovery from illness number compares, after treatment the moon laying rate and every day average feed intake, result is respectively as shown in table 1, table 2 and table 3.Wherein, like crust scabies shape Schultz-Charlton, skin there will not be gargalesthesia, and feather recovers normal, and healthy and strong, the glucose recoveries such as the incubation rate of female Columba livia and laying rate are normal; Invalid: clinical symptoms is not improved and even increased the weight of or death.

The incubation rate synopsis of each change of illness state of table 1 and female Columba livia:

Data from table 1: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 treatment 2-3 year age there is in Columba livia body acaricide advantage that is evident in efficacy, cheap, that have no side effect, improve the incubation rate of female Columba livia.

The time comparative example (%) of number of fully recovering afterwards for 6 days treated respectively by table 2 respectively group

Data from table 2: pharmaceutical composition of the present invention to treatment 2-3 year age Columba livia body acaricide, relative to conventional medicament on therapeutic effect, there is significant improvement, obviously shorten treatment the course for the treatment of.

Table 3 respectively group comparison therapy after 30 days, Columba livia the moon laying rate and every day average feed intake index synopsis

As can be seen from the data of table 3, compared with the Columba livia suffering from body acaricide fed with conventional medicament, adopt the Columba livia suffering from body acaricide containing medicine composite for curing of the present invention, have and improve the average feed intake of Columba livia and the advantage of laying rate.

Model case:

The Columba livia in 400 2-3 ages in year of the foster Columba livia smallholder operating of in January, 2014 Taian Shandong, female, male than being 7:1, nearly there is its abdominal part in 160 Columba livias, back, in the skin of lower limb and afterbody, there is seemingly crust scabies shape erythra in various degree, skin has obvious gargalesthesia, shed feathers, health is weak, the symptom such as at the bottom of the incubation rate of female Columba livia and laying rate, even there are the phenomena of mortality, dead Columba livia is dissected, visible abdominal part under the microscope, back, polypide subcircular or ellipse is had in the skin of lower limb and afterbody, the back side is swelled, milky white or light yellow, female demodicid mite size is 0.4 × 0.3mm, male demodicid mite size is 0.2 × 0.15mm.Gnathosoma is short and small, is positioned at front end, and chelicera is as tong-like, and there is little tooth at tip, has antenna and mouth to stretch out external.Columba livia body acaricide is diagnosed as with analysing according to above-mentioned epidemiology.Place is raised immediately by not occurring that the Columba livia of above-mentioned symptom isolates.Random selecting 50 ill Columba livias wherein, start to feed and be added with the feedstuff of the embodiment of the present invention 2 powder, powder is mixed in conventional feed according to 0.3g:40g weight ratio, and feed 6 days continuously, within the 1st day, ill Columba livia symptom is obviously improved, within 2nd day, 50 Columba livias are all fully recovered, after continuing to feed 4 days, compared with healthy Columba livia, average weight feed intake improves, shorten administration time interval and times for spraying, the incubation rate of female Columba livia and the advantage of laying rate can also be improved.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. one kind is used for the treatment of the pharmaceutical composition of Columba livia body acaricide, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Cortex Meliae, Bulbus Allii, Thyreoid Bovis seu Bubali, Aloe, Flos Genkwa, Folium sidae alnifoliae, le bamboo, Herba Polygoni Avicularis, Fructus Evodiae, lotus throne lead fungi, Long Xuguan, thousand bend grass, Cortex Ailanthi, Radix diurantherae majoris, LONGHU, Herba polygoni hydropiperis, Folium Raphani, Herba Lysimachiae foenum-graeci, the Radix Aucklandiae, top sieve Radix Asteris, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Semen Lepidii, Radix Trichosanthis, Rhizoma Smilacis Glabrae, Herba Commelinae, shamrock, Herba Taraxaci, sesbania, Herba Violae japonicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) and Pseudobulbus Cremastrae Seu Pleiones.

2. the pharmaceutical composition being used for the treatment of Columba livia body acaricide according to claim 1, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 10-22 weight portion, Bulbus Allii 7-15 weight portion, Thyreoid Bovis seu Bubali 5-10 weight portion, Aloe 10-20 weight portion, Flos Genkwa 3-5 weight portion, Folium sidae alnifoliae 11-21 weight portion, le bamboo 12-24 weight portion, Herba Polygoni Avicularis 8-16 weight portion, Fructus Evodiae 10-26 weight portion, lotus throne lead fungi 14-26 weight portion, dragon palpus tabernaemontanus bulrush 12-22 weight portion, thousand bend careless 15-35 weight portion, Cortex Ailanthi 10-20 weight portion, Radix diurantherae majoris 12-26 weight portion, the sub-15-35 weight portion of LONGHU, Herba polygoni hydropiperis 14-32 weight portion, Folium Raphani 10-20 weight portion, Herba Lysimachiae foenum-graeci 12-28 weight portion, Radix Aucklandiae 11-23 weight portion, top sieve Radix Asteris 14-26 weight portion, Rhizoma Anemarrhenae 12-31 weight portion, Rhizoma Phragmitis 10-22 weight portion, Semen Lepidii 7-14 weight portion, Radix Trichosanthis 15-35 weight portion, Rhizoma Smilacis Glabrae 12-28 weight portion, Herba Commelinae 14-36 weight portion, shamrock 15-30 weight portion, Herba Taraxaci 12-22 weight portion, sesbania 10-30 weight portion, Herba Violae japonicae 12-30 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 13-25 weight portion and Pseudobulbus Cremastrae Seu Pleiones 10-20 weight portion.

3. the pharmaceutical composition being used for the treatment of Columba livia body acaricide according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 14 weight portion, Bulbus Allii 8 weight portion, Thyreoid Bovis seu Bubali 7 weight portion, Aloe 18 weight portion, Flos Genkwa 3 weight portion, Folium sidae alnifoliae 14 weight portion, le bamboo 22 weight portion, Herba Polygoni Avicularis 14 weight portion, Fructus Evodiae 22 weight portion, lotus throne lead fungi 19 weight portion, dragon palpus tabernaemontanus bulrush 13 weight portion, thousand bend careless 32 weight portions, Cortex Ailanthi 15 weight portion, Radix diurantherae majoris 25 weight portion, LONGHU 35 weight portions, Herba polygoni hydropiperis 17 weight portion, Folium Raphani 12 weight portion, Herba Lysimachiae foenum-graeci 24 weight portion, the Radix Aucklandiae 22 weight portion, top sieve Radix Asteris 16 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Rhizoma Phragmitis 16 weight portion, Semen Lepidii 10 weight portion, Radix Trichosanthis 34 weight portion, Rhizoma Smilacis Glabrae 24 weight portion, Herba Commelinae 32 weight portion, shamrock 28 weight portion, Herba Taraxaci 16 weight portion, sesbania 12 weight portion, Herba Violae japonicae 25 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 22 weight portion and Pseudobulbus Cremastrae Seu Pleiones 15 weight portion.

4. the pharmaceutical composition being used for the treatment of Columba livia body acaricide according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises Rhizoma begoniae pedatifidae, Yichang Caulis Viburni Dilatati, Fructus elaeagni glabrae, Herba Hyperici perforati, Liquor chrysanthemi Distillata and Herba pyrrosiae mollis.

5. the pharmaceutical composition being used for the treatment of Columba livia body acaricide according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 10-22 weight portion, Bulbus Allii 7-15 weight portion, Thyreoid Bovis seu Bubali 5-10 weight portion, Aloe 10-20 weight portion, Flos Genkwa 3-5 weight portion, Folium sidae alnifoliae 11-21 weight portion, le bamboo 12-24 weight portion, Herba Polygoni Avicularis 8-16 weight portion, Fructus Evodiae 10-26 weight portion, lotus throne lead fungi 14-26 weight portion, dragon palpus tabernaemontanus bulrush 12-22 weight portion, thousand bend careless 15-35 weight portion, Cortex Ailanthi 10-20 weight portion, Radix diurantherae majoris 12-26 weight portion, the sub-15-35 weight portion of LONGHU, Herba polygoni hydropiperis 14-32 weight portion, Folium Raphani 10-20 weight portion, Herba Lysimachiae foenum-graeci 12-28 weight portion, Radix Aucklandiae 11-23 weight portion, top sieve Radix Asteris 14-26 weight portion, Rhizoma Anemarrhenae 12-31 weight portion, Rhizoma Phragmitis 10-22 weight portion, Semen Lepidii 7-14 weight portion, Radix Trichosanthis 15-35 weight portion, Rhizoma Smilacis Glabrae 12-28 weight portion, Herba Commelinae 14-36 weight portion, shamrock 15-30 weight portion, Herba Taraxaci 12-22 weight portion, sesbania 10-30 weight portion, Herba Violae japonicae 12-30 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 13-25 weight portion, Pseudobulbus Cremastrae Seu Pleiones 10-20 weight portion, Rhizoma begoniae pedatifidae 15-30 weight portion, Yichang Caulis Viburni Dilatati 10-22 weight portion, Fructus elaeagni glabrae 9-18 weight portion, Herba Hyperici perforati 14-26 weight portion, Liquor chrysanthemi Distillata 15-35 weight portion and Herba pyrrosiae mollis 12-28 weight portion.

6. the pharmaceutical composition being used for the treatment of Columba livia body acaricide according to any one of claim 1-5, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Cortex Meliae 14 weight portion, Bulbus Allii 8 weight portion, Thyreoid Bovis seu Bubali 7 weight portion, Aloe 18 weight portion, Flos Genkwa 3 weight portion, Folium sidae alnifoliae 14 weight portion, le bamboo 22 weight portion, Herba Polygoni Avicularis 14 weight portion, Fructus Evodiae 22 weight portion, lotus throne lead fungi 19 weight portion, dragon palpus tabernaemontanus bulrush 13 weight portion, thousand bend careless 32 weight portions, Cortex Ailanthi 15 weight portion, Radix diurantherae majoris 25 weight portion, LONGHU 35 weight portions, Herba polygoni hydropiperis 17 weight portion, Folium Raphani 12 weight portion, Herba Lysimachiae foenum-graeci 24 weight portion, the Radix Aucklandiae 22 weight portion, top sieve Radix Asteris 16 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Rhizoma Phragmitis 16 weight portion, Semen Lepidii 10 weight portion, Radix Trichosanthis 34 weight portion, Rhizoma Smilacis Glabrae 24 weight portion, Herba Commelinae 32 weight portion, shamrock 28 weight portion, Herba Taraxaci 16 weight portion, sesbania 12 weight portion, Herba Violae japonicae 25 weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 22 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15 weight portion, Rhizoma begoniae pedatifidae 30 weight portion, Yichang Caulis Viburni Dilatati 20 weight portion, Fructus elaeagni glabrae 9 weight portion, Herba Hyperici perforati 14 weight portion, Liquor chrysanthemi Distillata 35 weight portion and Herba pyrrosiae mollis 22 weight portion.

7. the pharmaceutical composition being used for the treatment of Columba livia body acaricide according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

8. the pharmaceutical composition being used for the treatment of Columba livia body acaricide according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

9. the preparation method being used for the treatment of the pharmaceutical composition of Columba livia body acaricide as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

10. the preparation method being used for the treatment of the pharmaceutical composition of Columba livia body acaricide as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps: