CN105998979A

CN105998979A - Traditional Chinese medicine composition for treating lung-and-kidney-yin-deficiency-type chronic pharyngitis and method

Info

Publication number: CN105998979A
Application number: CN201610548070.XA
Authority: CN
Inventors: 杨高林
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-07-12
Filing date: 2016-07-12
Publication date: 2016-10-12

Abstract

The invention provides a traditional Chinese medicine composition for treating lung-and-kidney-yin-deficiency-type chronic pharyngitis. The orally-taking medicine of the traditional Chinese medicine composition is prepared from 10-20 parts of cortex moutan, 10-20 parts of exocarpium citri rubrum, 10-20 parts of Chinese yam, 10-20 parts of semen cuscutae, 10-20 parts of radix stemonae, 10-20 parts of mangnolia officinalis, 10-20 parts of radix bupleuri, 10-20 parts of isatis roots, 10-20 parts of licorice roots, 10-20 parts of platycodon grandiflorum, 10-20 parts of semen oroxyli, 10-20 parts of poria cocos, 10-20 parts of rhizoma anemarrhenae, 10-20 parts of dogwood, 10-20 parts of the root bark of white mulberry, 10-20 parts of roots of Chinese trichosanthes, 10-20 parts of oldenlandia diffusa, 10-20 parts of golden cypress, 10-20 parts of roots of common peony, 10-20 parts of prepared rehmannia roots and 10-20 parts of burdock. According to the traditional Chinese medicine composition, orally taking and externally using are combined to have the effects of nourishing the lung and the kidney, clearing heat, relieving sore throat, regulating qi for strengthening the spleen, tonifying the kidney and moistening the lung, both symptoms and root causes are treated, using in clinic is achieved accordingly, and the treating effect is achieved every time the medicine is adopted.

Description

A kind of Chinese medicine composition treating YIN-deficiency type of the lung and kidney chronic pharyngitis and method

Technical field

The present invention relates to containing the pharmaceutical product deriving from plant, animal or mineral component, particularly to A kind of Chinese medicine composition treating YIN-deficiency type of the lung and kidney chronic pharyngitis and preparation method thereof.

Background technology

The traditional Chinese medical science thinks that chronic pharyngitis is many by ferritic YIN-deficiency of the lung and kidney, or acute pharyngitis due to wind-heat recurrent exerbation, and remaining heresy is detained Unclear, impairment of body fluid consumption liquid, cause consumption of YIN-fluid, throat loses in moistening foster, furthermore disturbs in asthenic fire, sends out as primary disease. Therefore YIN-deficiency type of the lung and kidney chronic pharyngitis is more common type, its disease, pathogenesis, method for the treatment of, side's medicine are as follows.

1, syndrome: pharyngeal dry pain is uncomfortable, burning sensation, foreign body sensation, or the few expectorant of itching throat, heavy towards light dusk, Can check see that pharyngeal mucosa is dark red, dry with diseases such as hectic fever in the afternoon, fidgets due to deficiency insomnia, soreness of the waist and knees.

2, pathogenesis: lung kidney consumption of YIN-fluid, throat loses in moistening foster；Hyperactivity of fire caused by deficiency of YIN, asthenic fire is disturbed, and refines Tianjin Become expectorant；YIN-fluid being insufficient, asthenic fire disturbs the heart, so that all Symptoms of YIN-deficiency of the lung and kidney.

3, method for the treatment of: nourishing YIN to lower pathogenic fire, moisturizes sore-throat relieving.

When patients with chronic pharyngitis is gone to a doctor, the usually pharyngeal discomfort of main suit, itching throat is coughed, pharyngeal if any thing resistance, That tells does not goes out, and can not swallow, and the most frequently sends the sound of " noise made in coughing or vomiting of uttering a sound or a word ".Here it is the traditional Chinese medical science is referred to as " chronic throat obstruction, chronic pharyngitis " Disease.This disease mostly occurs in middle age, and the course of disease is long, and symptom is more, recurrent exerbation, is difficult to control More.The traditional Chinese medical science thinks the door that throat is lung stomach, if any accumulated heat in the lung and stomach, and burning hot upper inflammation, stifling throat；Or Because of deficiency of kidney-YIN, hyperactivity of deficient fire, decocting the body fluid that burns, all can cause pharyngeal chronic congestion, mucosa is dried, throat Lose and support and fall ill.The traditional Chinese medical science of having a talk below is how to treat chronic pharyngitis.

This sick palpus prevention of diseae:

1. having regular daily life: keeping room air fresh is one of effective measures preventing and treating chronic pharyngitis.Room is also Suitable temperature and humidity should be maintained.Air is dried and supercool, overheated, overly moist all can affect pharyngeal mucosa Defensive enginery, cause pharyngeal paraesthesia, with the passing of time cause chronic pharyngitis pathological changes.Morning to be accomplished, After meal and gargle, brush teeth before sleep, keep oral cavity cleaning.

2. adjusting diet: diet is the lightest, food delicious food savoury and oil squeeze the food of food less.Season in spring and autumn eats more Some have the food of sour sweet YIN nourishing, such as Fructus Citri tangerinae, Fructus Canarii albi, pear, Fructus Canarii and fresh vegetables etc..

3. move health preserving: strengthen taking exercise, health invigorating, reach the purpose of " in healthy energy is deposited, heresy can not be done ". Reduce tobacco and wine and dust etc. to stimulate, correct the bad habits such as mouth breathing.Also to avoid excessively pronouncing.

4. preventing diseases caused by external factors: active prevention respiratory tract infection, actively preventing and treating mouth and nose and laryngopharyngeal diseases.

Chronic pharyngitis can be individually present, it is possible to is secondary to other position inflammation perhaps many whole bodies diseases of upper respiratory tract Sick.Chronic pharyngitis is controlled not in time, also can cause general malaise, even hoarseness.Therefore must promptly treat. The traditional Chinese medical science can be divided into the different pattern of syndrome such as accumulated heat in the lung and stomach, phlegm stagnation heat, YIN-deficiency of the lung and kidney according to its clinical manifestation.This Disease needs determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs:

(1) accumulated heat in the lung and stomach, clinical syndrome: dry mouth and tougue, discomfort in the throat, dry cough expectorant is few and yellow, pharynx Portion's mucosa is red red, yellow urine, big dry stool, red tongue with yellow fur, rapid pulse or reality.Method for the treatment of: lung heat clearing gastric heat, removes Expectorant sore-throat relieving.Prescription: powder for clearing lung-heat closes QINGWEI SAN plus-minus.

(2) phlegm stagnation heat, clinical syndrome: parched throat hypodynia, foreign body in pharynx sense is obvious, and that tells does not goes out, Can not swallow, when feelings will is not smooth more so, being irritable and getting angry easily, the breast side of body is vexed swollen, swallows rear wall follicle hypertrophy, stool Uncomfortable, red tongue or light red, yellow and greasy fur, wiry and frequent pulse.Method for the treatment of: Shugan Qingre, reduce phlegm sore-throat relieving.Prescription: Danzhi Xiaoyao San is added and subtracted.

(3) YIN-deficiency of the lung and kidney, clinical syndrome: pharyngeal be dried, scorching hot pain, the most heavier, or pharyngeal not Profit, dry cough expectorant is few and thick, and pharyngeal mucosa is dark red, dysphoria with feverish sensation in the chest palms and soles, red tongue with a little fluid, thready and rapid pulse.Method for the treatment of: Nourishing lung and kidney, relieving sore-throat by clearing away heat.

Chronic simple pharyngitis is controlling various paathogenic factors, is keeping good living habit and apply various controlling Can alleviating after treatment until curing, otherwise delay may become chronic hypertrophic pharyngitis；Chronic hypertrophic is swallowed Scorching and atrophic or chronic pharyngitis sicca therapeutic effect is not good enough, and symptom is the most repeatedly；Chronic allergic Property pharyngitis depart from symptom after sensitinogen and can alleviate to disappearance；After chronic reflux pharyngitis controls gastroesophageal reflux Symptom can substantially be alleviated until curing.

Summary of the invention

The technical problem to be solved is, YIN-deficiency type of the lung and kidney chronic pharyngitis, and clinical manifestation exists: Pharyngeal dry, scorching hot pain, the most heavier or pharyngeal unfavorable, dry cough expectorant is few and thick, and pharyngeal mucosa is dark Red, dysphoria with feverish sensation in the chest palms and soles, red tongue with a little fluid, thready and rapid pulse.Method for the treatment of: nourishing lung and kidney, relieving sore-throat by clearing away heat.Doctor trained in Western medicine is general Solve with chemicals, though there being certain curative effect, instant effect, but easily have side effect in various degree or draw Play some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, document money Material is abundant, clinical efficacy is good and enjoys favor.But existing prescription specific aim is poor, it is impossible to fundamentally delay Solve the symptom of chronic pharyngitis, and the most certain side effect.Therefore, find in a kind of highly effective and safe Drug composition becomes the urgent needs of people.

For solving these technical barriers, the invention provides a kind for the treatment of in YIN-deficiency type of the lung and kidney chronic pharyngitis Drug composition, its described Chinese medicine composition is made up of with external used medicine endo-medicine, and endo-medicine can wrap Include the crude drug of following parts by weight: Cortex Moutan 10～20 parts, Exocarpium Citri Rubrum 10～20 parts, Rhizoma Dioscoreae 10～20 parts, Semen Cuscutae 10～20 parts, the Radix Stemonae 10～20 parts, Cortex Magnoliae Officinalis 10～20 parts, Radix Bupleuri 10～20 parts, Radix Isatidis 10～ 20 parts, Radix Glycyrrhizae 10～20 parts, Radix Platycodonis 10～20 parts, Semen Oroxyli 10～20 parts, Poria 10～20 parts, know Female 10～20 parts, Fructus Corni 10～20 parts, Cortex Mori 10～20 parts, Radix Trichosanthis 10～20 parts, Agkistrodon SHECAO 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Paeoniae Rubra 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, Fructus Arctii 10～ 20 parts.

In described Chinese medicine composition, external used medicine can include the crude drug of following parts by weight: watermelon crystal 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, the Radix Stemonae 10～20 parts, Herba Menthae 10～20 parts, Cortex Moutan 10～20 parts, Rhizoma Alismatis 10～20 parts, Fructus Momordicae 10～20 parts, Borneolum Syntheticum 10～20 parts, Radix Isatidis 10～20 parts, Radix Clematidis 10～20 parts.

The Chinese medicine composition of described treatment YIN-deficiency type of the lung and kidney chronic pharyngitis, its described endo-medicine can also wrap Include the crude drug of following parts by weight: Cortex Moutan 10～15 parts, Exocarpium Citri Rubrum 10～15 parts, Rhizoma Dioscoreae 10～15 parts, Semen Cuscutae 10～15 parts, the Radix Stemonae 10～15 parts, Cortex Magnoliae Officinalis 10～15 parts, Radix Bupleuri 10～15 parts, Radix Isatidis 10～ 15 parts, Radix Glycyrrhizae 10～15 parts, Radix Platycodonis 10～15 parts, Semen Oroxyli 10～20 parts, Poria 10～20 parts, know Female 10～20 parts, Fructus Corni 10～20 parts, Cortex Mori 10～20 parts, Radix Trichosanthis 10～20 parts, Agkistrodon SHECAO 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Paeoniae Rubra 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, Fructus Arctii 10～ 20 parts.

Described external used medicine can also include the crude drug of following parts by weight: watermelon crystal 10～15 parts, in vain The root of Dahurian angelica 10～15 parts, the Radix Stemonae 10～15 parts, Herba Menthae 10～15 parts, Cortex Moutan 10～15 parts, Rhizoma Alismatis 10～20 parts, Fructus Momordicae 10～20 parts, Borneolum Syntheticum 10～20 parts, Radix Isatidis 10～20 parts, Radix Clematidis 10～20 parts.

The Chinese medicine composition of described treatment YIN-deficiency type of the lung and kidney chronic pharyngitis, its described endo-medicine can also wrap Include the crude drug of following parts by weight: Cortex Moutan 10～20 parts, Exocarpium Citri Rubrum 10～20 parts, Rhizoma Dioscoreae 10～20 parts, Semen Cuscutae 10～20 parts, the Radix Stemonae 10～20 parts, Cortex Magnoliae Officinalis 10～20 parts, Radix Bupleuri 10～20 parts, Radix Isatidis 10～ 20 parts, Radix Glycyrrhizae 10～20 parts, Radix Platycodonis 10～20 parts, Semen Oroxyli 10～15 parts, Poria 10～15 parts, know Female 10～15 parts, Fructus Corni 10～15 parts, Cortex Mori 10～15 parts, Radix Trichosanthis 10～15 parts, Agkistrodon SHECAO 10～15 parts, Cortex Phellodendri 10～15 parts, Radix Paeoniae Rubra 10～15 parts, Radix Rehmanniae Preparata 10～15 parts, Fructus Arctii 10～ 15 parts.

Described external used medicine can also include the crude drug of following parts by weight: watermelon crystal 10～20 parts, in vain The root of Dahurian angelica 10～20 parts, the Radix Stemonae 10～20 parts, Herba Menthae 10～20 parts, Cortex Moutan 10～20 parts, Rhizoma Alismatis 10～15 parts, Fructus Momordicae 10～15 parts, Borneolum Syntheticum 10～15 parts, Radix Isatidis 10～15 parts, Radix Clematidis 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for one and treats YIN-deficiency type of the lung and kidney chronic pharyngitis Chinese medicine The preparation method of compositions, its described endo-medicine is that the preparation method of granule comprises the following steps:

A. the extraction of raw material medicinal alcohol is taken, as component 1；

B. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component 2；

C. by 2-in-1 for component 1 component and be condensed into extractum, add dextrin and make granule.

In described step a, all crude drug can be shredded, be soaked and be placed in lid stainless steel cask, Adding 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, Make fully to expand；Filter plate gauze bag bottom percolator is wrapped up after paving again by the medicine after moistening expansion Sample is mixed pine and is done to dissipate, and then contains powder with rustless steel spoon, loads percolator uniformly, fills 10-12 cm thick, Even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurize, medicated powder must not load Exceed 2/3 eminence of percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the blowing below percolator Valve, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, And have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open Material valve carries out percolation, controls percolation speed and is generally 1000g medical material outflow per minute 2～3ml, and filtrate is put Enter in liquid container, and pour ethanol during emptying into liquid container；Percolate is merged and stands, stand standby With, as component 1.

In described step b, can above-mentioned stripped raw material residue be put in 10 times amount water, soak 1-2 Hour, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh filters, The ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C time 1.05 filtrate, as component 2.

In described step c, can be by 2-in-1 also, when concentrating under reduced pressure relative density is 70 DEG C to component 1 and component The filtrate of 1.38, reclaims ethanol, by gained filtrate adjustment proportion to 1.60, is passed through spray dryer and carries out Being spray-dried, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m², hothouse hot stream temperature It is 100 DEG C, obtains raw material medicated powder, be dried to powder, add dextrin and make granule.

For solving above-mentioned technical problem, the present invention also provides for one and treats YIN-deficiency type of the lung and kidney chronic pharyngitis Chinese medicine The preparation method of compositions, the external preparation of its described Chinese medicine composition is spray, and its preparation method is Following steps:

A. take the Radix Angelicae Dahuricae, Herba Menthae, the Borneolum Syntheticum way of distillation are vaporized into crystallization, pulverize dusting cover stand-by, as group Divide 1；

B. by remaining raw material except watermelon crystal external ethanol extraction, concentrate, as component 2；

C. after watermelon crystal being mixed with component 1 component 2, solubilizer, load in aerosol apparatus, the present invention does not contains Preservative, must cold preservation.

In described step a, can obtain first by the crude drug Radix Angelicae Dahuricae, Herba Menthae, the distillation of Borneolum Syntheticum steam method To crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.

In described step b, can will put in 10 times amount ethanol except remaining crude drug of watermelon crystal, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh Filter, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, ultrafiltrate concentrating under reduced pressure is the closeest The filtrate of 1.05 when degree is 80 DEG C, as component 2；Being put into by watermelon crystal in component 1 component 2, stirring is all Even, solubilizer, load in aerosol apparatus, the present invention does not contains preservative, must cold preservation.

Chronic pharyngitis is a kind of commonly encountered diseases, and chronic pharyngitis is more common in adult, and child also may occur in which.Whole body Symptom is the most inconspicuous, based on local symptom.Various chronic pharyngitis symptom is substantially similar and varied, As pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretions be difficult to bring up, pharyngeal gargalesthesia, burn feeling, dry sensation Or excitement, also can there is hypodynia sense.YIN-deficiency type of the lung and kidney chronic pharyngitis, clinical manifestation exists: pharyngeal dry pain is not Fit, burning sensation, foreign body sensation, or the few expectorant of itching throat, heavy towards light dusk, can have a sleepless night with hectic fever in the afternoon, fidgets due to deficiency, The diseases such as soreness of the waist and knees, check and see that pharyngeal mucosa is dark red, dry.Control suitable nourishing lung and kidney, relieving sore-throat by clearing away heat.West Doctor typically solves with chemicals, though there being certain curative effect, and instant effect, but easily have secondary work in various degree With or cause some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, Documents and materials are abundant, clinical efficacy is good and enjoys favor.Oral administration and externally amalgamation of the present invention, nourishes lung Kidney, relieving sore-throat by clearing away heat, regulating qi-flowing for strengthening spleen, kidney tonifying lung moistening, so, then treating both the principal and secondary aspects of a disease, therefore clinical with it, repeatly Control and imitate repeatly.

Detailed description of the invention

Chronic pharyngitis is for swallowing under mucosa, mucosa and adenoid chronic inflammatory disease.Diffusivity pharyngeal inflammation is normal A part for upper respiratory tract chronic inflammatory disease；Limitation pharyngeal inflammation mostly then is pharynx lymphoid tissue inflammation.This Sick common in clinic, the course of disease is long, the easy recurrent exerbation of symptom.From pathology, chronic pharyngitis can be divided For following 5 classes:

1. chronic simple pharyngitis

This type more typically, shows as pharyngeal mucosa chronic congestion.Pathological changes is concentrated mainly on pharyngeal mucosa Layer, has more lymphoid tissue to infiltrate, it is possible to see leukocyte and plasmocyte infiltrating around its blood vessel.Mucosa and Connective tissue proliferation under mucosa, can be loose with mucous gland, glandular secretion hyperfunctioning, and mucilage secretion increases Many and more sticky.

2. chronic hypertrophic pharyngitis

Also known as chronic particulate-pharyngitis and lateral pharyngitis, chronic simple pharyngitis protracted course of disease can form chronic fertilizer Thickness pharyngitis, this type is the most common in clinic.Pharyngeal mucous layer hyperemia thickens, mucosa and mucosa Under have connective tissue and lymphadenosis widely, the lymphadenosis projection around mucous gland, Performance pharynx rear wall multiple graininess lymph follicle, also can merge by multiple lymph follicles in chronic congestion shape It is integrated.Inflammatory exudate in mucous gland can be closed wherein, is formed at the top of lymph granule protuberance Cryptomere white point, visible yellow-white exudate during ulceration.This kind of chronic pharyngitis often involves lateral pharyngeal band lymphoid tissue, Make its hypertrophy plump, in streak.

3. atrophic and pharyngitis sicca

In clinic more rare.Their early stage mucous gland secretion reduce, secretions stiff and be dried.Continue because of glutinous Film lower floor chronic inflammatory disease, gradually sends out vitalization and contraction, compressing body of gland and blood vessel, makes glandular secretion reduce And malnutrition, cause the gradually atrophy of mucosa and Submucosa thinning.Dry crusts or pus crusts can be had on pharynx rear wall Attachment, generally entails stink.

4. chronic anaphylaxis pharyngitis

Also known as chronic allergia pharyngitis.For betiding the I allergic reaction type mediated by IgE of pharyngeal mucosa. Allergen stimulates pharyngeal mucosa, makes the plasma cell of synthesis IgM be converted into the plasma cell of synthesis IgE, and IgE is again It is attached to mastocyte, basophil cellular surface, makes pharyngeal mucosa be in sensitization.When identical After allergen contacts body again, allergen is combined with the IgE of medium cell surface, causes medium cell Retting conditions, release includes the multiple inflammatory mediator such as histamine, synthesis of prostaglandins, blood capillary can be caused to expand Open, vascular permeability increases, glandular secretion increases, and causes allergic reaction.And related allergy is former mainly Caused allergic reaction by Complement C_3, C4 approach.Chronic anaphylaxis pharyngitis occurs together in whole body allergia disease more Disease or allergic rhinitis, also can individually fall ill.Seasonal chronic anaphylaxis pharyngitis, its symptom can have season Property change.As to food anaphylaxis, the related symptoms of chronic pharyngitis can occur on the feed after sensitization food.

5. chronic reflux pharyngitis

Relevant to gastroesophageal reflux.Gastric juice is due to the pharyngeal mucosa of gastroesophageal reflux coup injury or by nerve Reflection causes the chronic inflammatory disease under pharyngeal mucosa and mucosa.

Chronic pharyngitis is more common in adult, and child also may occur in which.General Symptoms is the most inconspicuous, with local disease Shape is main.Various chronic pharyngitis symptom is substantially similar and varied, as pharyngeal sense of discomfort, foreign body sensation, Pharyngeal secretions is difficult to bring up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also can have hypodynia sense. Due to pharynx rear wall generally cause more sticky secretions to adhere to because of pharyngeal chronic inflammatory disease, and due to nose, nasal sinuses, Nasopharynx pathological changes causes mouth breathing at night, irritable cough occurs and feel sick when Chang Chen rises.Due to pharynx Portion's foreign body sensation can behave as frequently swallowing.Pharyngeal secretions is few and is difficult to expectoration person and often shows as habitually Dry cough and expectoration action of clearing one's throat, can cause pharyngeal mucosa hemorrhage if firmly coughing or clearing one's throat, and causes point Band blood in secretion.

Treatment: 1. removing the cause of disease, wine for giving off smoking, active treatment causes protopathy (the acute pharynx of chronic pharyngitis Scorching, nose and nasopharynx part chronic inflammatory disease, reflux gastroesophageal disorder, improve work and living environment).2. Lifestyle change, carries out the psychology that suitable physical training, normal work and rest, light diet, holding are good State is to improve pharyngeal mucosa local function state by strengthening self overall immune functional state.3. innings Portion's treatment (1) chronic simple pharyngitis, commonly uses the rinsing the mouth such as compound recipe Borax, furacilin solution, keeps Oral cavity, pharyngeal cleaning；Or buccal iodine lozenge, Mint throat lozenge etc. treat the lozenge of pharyngeal chronic inflammatory disease； Chinese medicine preparation as also there being certain curative effect to chronic pharyngitis；The available glycerinum iodi compositum in local, 5% silver nitrate molten Liquid or 10% argyrol solution smear pharyngeal, have convergence and antiinflammation；Ultrasonic atomizatio can be alleviated The symptom of chronic pharyngitis；Typically need not antibiotic therapy.

Radix Paeoniae Rubra enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing receives antiperspirant.Control the chest and abdomen pain over the hypochondriac region, Dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, and married woman's blood closes obstructed, Repercussive blood, can lose pus, benefit woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, And antenatal after all diseases, Tong Yueshui, bring down a fever, relieving restlessness, QI invigorating, the hot disease of sky row, pestilence miasma, mania and irritation, married woman Blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.Redness of the skin or complexion person Many QI invigorating, white person controls blood.

The Rhizoma Anemarrhenae, Classification system: Anemarrhena asphodeloides Bunge, is also RHIZOMA ANEMARRHENAE with peet, for many years The dry root stock of raw herbaceous plant this kind is famous Chinese medicine, property bitter cold, have nourishing YIN to lower pathogenic fire, moisturize laxation, The effect of profit defecation.Belong to gunpowder under heat clearing away, cure mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, Constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.There is dividing of " RHIZOMA ANEMARRHENAE with peet " and " unpeeled RHIZOMA ANEMARRHENAE ".The most main Want producing region in Hebei.Chinese medicine is called: rabbit Herba Leptochloae Chinensis, great Lu water, Ma Macao, garlic clove grass, furuncle Root, L.Lucidus Turcz. etc..

Radix Ophiopogonis, " book on Chinese herbal medicine lease making " claims that Radix Ophiopogonis, " hardship sweet, micro-, was slightly cold.Lung moistening clears away heart-fire, purge heat promote the production of body fluid, Reduce phlegm preventing or arresting vomiting, control row water of coughing "." Records of Tradition Chinese and Western Medicine in Combination " says it: " can enter stomach with nourishing the stomach liquid, appetizing Feed, spleen is scattered is skillful in lung, Dingchuan relieving coughing to help more to enter spleen." traditional Chinese medical science thinks, Radix Ophiopogonis sweet in the mouth, micro-hardship, Cold nature, returns stomach, lung, heart channel, has nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the effect of the relieving restlessness that clears away heart-fire, is used for Dryness of the lung dry cough, deficiency of YIN consumptive disease are coughed, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine just Secret disease such as grade.Modern pharmacological research also indicates that, Radix Ophiopogonis mainly containing dwarf lilyturf glycosides, steroidal saponin, alkaloid, Sitosterol, glucose, aminoacid, vitamin etc., have resisting fatigue, remove free radical, raising cell Immunologic function and hypoglycemic effect.It addition, have Radix Ophiopogonis calmness, hypnosis, resist myocardial ischemia, the anti-heart Restrain the effects such as not normal, antitumor, especially enhancement senior health and fitness is had many-sided effect.

Cortex Moutan, has another name called Cortex Moutan, Chinese medicine name.It is dried root bark for ranunculaceae peony.Originate in Anhui, The ground such as Shandong.Excavate root autumn, remove radicula, strip root bark, dry.Life is used or is fried and uses." this Grass detailed outline ": " nourishing YIN to lower pathogenic fire solves speckle poison, throat, diuresis stasis.Descendant is specially to control with yellow tiller Xiang Huo, does not knows that the merit of Cortex Moutan more wins also.Red colored person profit, the person of spending in vain mends, and people the most seldom realizes, and preferably distinguishes it.” Modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action；The methanol of Cortex Moutan Extract has suppression Platelet；Paeonol has the maincenters such as calmness, cooling, antipyretic, analgesia, spasmolytic Inhibitory action and atherosclerosis, diuresis, antiulcer etc. act on.

Radix Clematidis belongs to medicinal plants, and medical material Ji Yuan source is more, " Kaibao Bencao ", " Bencao Tujing ", The Radix Clematidis that herbal for Relief of Famines etc. are contained, for goatweed；The Radix Clematidis that " the southern regions of the Yunnan Province book on Chinese herbal medicine " is contained, Be feverfew, and use now mostly be " China book on Chinese herbal medicine " contained cohosh Radix Clematidis, cotton-wool Radix clematidis floridae, northeast clematis.Domestic distributed more widely, its root and stem be used as medicine have wind-damp dispelling, the meridian dredging, Disappear effect of bone stalk.In modern clinic is put into practice, its new purposes is constantly found, as treated cholelithiasis, Calcanean spur, chronic pharyngitis, the esophageal carcinoma etc..Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, dissipate the hypochondriac lump. Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, muscle arteries and veins contracture, joint stuffiness, tinea pedis, Malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat swallow.Tang Materia Medica: waist, kidney, foot Knee joint, accumulation, all cold diseases of enteral, be not recovered, the effect of clothes." Kaibao Bencao ": main all wind, Xuan Tong Five hide, and cold stagnant in removing abdomen, septum cordis expectorant water amasss for a long time, and lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, waist knee joint is cold Pain and treatment injured.

Its root of Radix Platycodonis can be used as medicine, and has the effects such as eliminating phlegm and stopping cough, lung qi dispersing, evacuation of pus, traditional Chinese medical science common medicine.In The Northeast of state is often pickled as brined vegetable, is used in the Korea peninsula make Pickles.Lung qi dispersing, sore-throat relieving, dispel Expectorant, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection pus becomes. Antiinflammatory action: thick kikyosaponin has antiinflammatory action, gavages the dosage of 1/10～1/5 median lethal dose(LD 50) to greatly Mus hind leg chondrus ocellatus Holmes colloidality swelling of the feet and acetic acid swelling all have antiphlogistic effects.Gavage is less than 1/10 median lethal The dosage of amount, every day 1 time, successive administration, also there is significant inhibitory action to rat granuloma is swollen, and The most effective to rat assist agent arthritis.This kind of preparation can also reduce anaphylaxis, the blood capillary of mice Permeability.The mouse writhing that lumbar injection kikyosaponin causes reacts and Abdominal effusion, the same Saponin of gavage Suppression can be produced.Radix Platycodonis is without direct antibacterial action, but its water extract can strengthen macrophage phagocytic function, Strengthen the sterilizing power of neutrophilic leukocyte.Improve the activity of lysozyme.

Semen Cuscutae: Cuscuta chinensis be dicotyledon scammonia section plant Semen Cuscutae, Cuscuta australis, The seed of cuscuta japonica Choisy etc., can the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, effect of solid tire stopping leak.Nourishing the liver and kidney, solid Final minification is urinated, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, the acid of waist knee joint Soft, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney vaginal bleeding during pregnancy, frequent fetal movement, spleen are suffered from a deficiency of the kidney and are rushed down；Outward Curing vitiligo.Former medicine sieve is removed spare, picks decontamination, dry.

Radix Glycyrrhizae is used for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc..Before Person, normal and Ramulus Cinnamomi compatibility, such as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter, is often equal to Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae With, such as ball etc. in decoction of four noble drugs, reason.For ulcer sores, laryngopharynx swelling and pain etc..Can be alone, for oral administration or External application, or compatibility application.Ulcer sores, is often equal to use with Flos Lonicerae, Fructus Forsythiae, play altogether heat-clearing and toxic substances removing it Merit, such as Xian fang Huoming Yin.Laryngopharynx swelling and pain, the normal and same use of Radix Platycodonis, such as Radix Platycodonis decoction.If in pesticide, food Poison, often joins Semen phaseoli radiati or is decocted in water for oral dose with Radix Saposhnikoviae.For asthma and cough.Can be alone, also can compatibility other drug Application.As controlled the ERCHEN TANG of cough due to damp-phlegm；Control the Linggan Wuwei Jiangxin Tang of cold-phlegm cough with asthma；Control dry stool phlegm cough Sangxing decoction；Control pyretic toxicity and cause lung abscess cough and spit and smell as of rotten fish the Radix Platycodonis decoction of purulent sputum；Control the Gancao Ganjiang of cough and spit saliva foam Soup etc..Another cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough also Chang Peiwu application.For having a stomachache, suffer from abdominal pain and Gastrocnemius contraction urgency pain etc..For being in harmonious proportion the strong of some drugs.As seasoning CHENGQI TANG relaxes big by this product Yellow, the discharge function of Natrii Sulfas and gastrointestinal is stimulated.It addition, also commonly use this product in many prescriptions Coordinating the actions of various ingredients in a prescription.

Semen Oroxyli sore-throat relieving lung moistening；Dispersing the stagnated liver-QI for regulating the stomach；Expelling pus and promoting granulation.Cure mainly: pharyngalgia sore throat；Hoarseness； Cough；Stomachache due to hyperactive liver-QI attacking the stomach；Skin infection is burst for a long time and is not held back；Acute eczema.Effect is classified: antitussive；The lung moistening medicine；With Stomach medicine.Medical material Ji Yuan: for the mature seed of Bignoniaceae plant oroxylum indicum.Come from supplementary Amplifications of the Compendium of Materia Medica Seed, peel of stem contain baicaligenin, have antiinflammatory, antiallergic action, diuresis, function of gallbladder promoting, the work of cholesterol reducing With.

Exocarpium Citri Rubrum, Chinese medicine name.For rutaceae orange Citrus reticulata Blanco and variety thereof It is dried outside rind.Gather after time of the year when autumn changes into winter fruit maturation, cut lower outer peel with cutter, dry or dry in the shade. Acrid in the mouth, hardship, warm in nature.Return lung, spleen channel.Effect regulating the flow of QI to ease the stomach, drying dampness to eliminate phlegm.Cure mainly for coughing Abundant expectoration, food stagnation gets sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.Compendium of Material Medica: therapeutic method to keep the adverse QI flowing downwards expectorant." herbal classic is met former ": Fructus Citri tangerinae Red and expert main lung cold cough excessive phlegm, deficient side multiplex it, right chronic cough diarrhea due to stagnation of QI, the most non-preferably." medicineization justice ": Exocarpium Citri Rubrum, pungent eliminating stagnation of walking crosswise, bitter decline of keeping straight on, for promoting the circulation of QI key medicine.Lid is controlled expectorant and must be regulated the flow of vital energy, diarrhea due to disorder of QI expectorant Spontaneous recovery, therefore with entering lung spleen, all expectorant main are sick, and merit occupies on all expectorant medicines.Assistant Caulis Bambusae In Taenia, to treat heat-hiccup, helps green grass or young crops Skin is with intestinal stasis relieving gas, real in the flat stomach of same Rhizoma Atractylodis, Cortex Magnoliae Officinalis, the heresy that conjunction Bulbus Allii Fistulosi, Herba Ephedrae exterior cold are wet, rapid digestion of food gas, Alcoholic intoxication, anti-nausea, to open chest and diaphragm painful abdominal mass plug, Chen Zhixin can be pushed away, the power of the most pungent scattered bitter fall is also.

Poria sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.Effect promoting diuresis to eliminate damp pathogen, spleen invigorating, Mind calming.Cure mainly for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, Palpitation with fear insomnia.Compendium of Material Medica: Poria abnormal smells from the patient is light and oozes, and its property is up, born fluid, loosing the interspaces of skin and muscles, Grow water source and decline, diuresis, therefore Zhang Jiegu calls its genus sun, floats and rises, says its property also；Dong Yuan calls it For the YIN aspect of YANG, fall and under, Yan Qigong is also.Amplification on Canon of Materia Medica: Poria, Poria cum Radix Pini, the merit of row water is many, Heart-spleen boosting can not fault also.

Radix Trichosanthis, Chinese medicine name." book on Chinese herbal medicine justice ": medicine what is called Radix Trichosanthis person wantonly, i.e. with root section of withering With it, there is the name of powder, real without powder.Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, For clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling.Cure mainly: Control that calentura is thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional It with drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease.

Radix Bupleuri, Chinese medicine name.The medical herbs included for " Chinese Pharmacopoeia ", medicinal part is samphire bavin Hu or the dry root of Radix Bupeuri Scorzonerfolii..Spring, season in autumn two excavate, and remove stem and leaf and silt, are dried.Radix Bupleuri is Conventional diaphoretic medicine.Another name ground smoke, mountain dish, mushroom grass, faggot, nature and flavor hardship, be slightly cold, return liver, gallbladder meridian. There are reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, Sternal rib pain, proctoptosis, uterine prolapse, menoxenia.

Fructus Momordicae, the fruit of the perennial liana of Cucurbitaceae.Fruits nutrition is worth the highest, containing enrich Vitamin C (in every 100 grams of fresh fruits containing 400 milligrams～500 milligrams) and glucoside, fructose, glucose, Protein, lipid etc..Fructus Momordicae sweet in the mouth is cool in nature, returns lung, large intestine channel, has nourishing the lung to arrest cough, promoting the production of body fluid to quench thirst Effect, be applicable to lung-heat or xeropulmonary cough, pertussis and summer-heat impairment of body fluid are thirsty etc., in addition with intestine moistening Effect of relieving constipation.

Herba Menthae is one of China's conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, head Pain, conjunctival congestion, fever of the body, throat, dental bed such as swell and ache the disease.External can training the mind dysmenorrhoea, skin pruritus, erythra With eczema etc..Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.

The root of Radix Scutellariae is used as medicine, bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the merit such as antiabortive Effect.Cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, The diseases such as conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical antibiotic property of Radix Scutellariae is better than Rhizoma Coptidis, and And do not develop immunity to drugs.

It is strong that Rhizoma Dioscoreae has nourishing, aid digestion, holds back sweating due to debility, and effect of antidiarrheal cures mainly insufficiency of the spleen diarrhoea, lung Empty cough, diabetes are quenched one's thirst, oliguria frequency, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis. Rhizoma Dioscoreae optimum is taken with Ganoderma collocation, has the effect preventing and treating diabetes, and Rhizoma Dioscoreae is in grocery trade and processing In industry the most rising.

It is cold in nature for Radix Isatidis, taste the most micro-sweet after pained, there is the merit of heat-clearing and toxic substances removing, preventing cold, sore-throat relieving Effect.It is mainly used in treating the disease such as maculae caused by violent heat pathogen, purple dark, the scarlet fever of crimson tongue.Research shows, Baphicacanthus cusia The rhizome extract of root is divided by limiting virus and plays type A avian influenza virus, B-mode avian influenza The suppression killing action of poison, the aqueous solution of its extract has inhibitory action to common cold virus.Convection current Row epidemic cerebrospinal meningitis B virus has suppression and killing action.Various bacteria is also had suppression to make by Isatis indigotica Fort. root

With. infusion to bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will he, Freund) bacillus, bacillus enteritidis etc. have suppression in various degree to make With；Acetone leachate also has similar effect, and (all puts down with agar aperture Hemolytic streptococcus is effective Plate method). similar to bacteriostasis and Bulbus Allii, the Flos Lonicerae of A type meningococcus. infected by influenza PR8 strain and Jing Ke 68-1 strain have obvious inhibiting effect. and in vitro Radix Isatidis is killed leptospiral Effect.

Cortex Mori prescription is called.Come from Shennong's Herbal.For dicotyledon Moraceae Moraceae Mulberry The root bark of Morus alba L..Whole nation most area has product.In long and that distort en plaque, tubular or Both sides are inwardly rolled into channel-shaped, and length width differs, thick 0.1-0.5cm, skin depth, mealiness white with color Foot person is preferred.Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For diseases such as lung-heat cough with asthma, the edema of the face, dysuria.

Its patent medicine bitter in the mouth of Herba Hedyotidis Diffusae, light, cold in nature.Primary efficacy be heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, Promoting urination to remove dampness.Outstanding kind treatment all kinds inflammation.In clinical practice, if finding Herba Hedyotidis Diffusae compatibility Proper, multiple disease can be treated.In vitro tests shows that this product antibacterial potency is the lowest, but rear infection for oral administration Effect substantially, is by stimulating reticuloendothelial system, increases phagocytic activity of leukocytes to improve serum sterilizing Power, the ability relatively matched group of administration group leukocytes phagocytic Congo red improves 4 times.RE seen from microscopy The notable hypertrophy of system, skein cell hypertrophy, endochylema enriches, and phagocytosis is active, lymph node, spleen, liver Being that densification changes Deng argentophile substance in tissue, display body defenses function is strengthened.Humoral immunization can be strengthened Function, makes hemolysis plaque number in mouse spleen dramatically increase.

Fructus Arctii has dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, effect of removing toxic substances and promoting subsidence of swelling.Belong to solution Wind-heat-dispersing medicinal in medicine administered to bring out the cold.Modern study, Fructus Arctii can be additionally used in preventing and treating diabetic nephropathy；Arctium lappa fruit The arctigenin generated through hydrolysis containing arctigenin has active anticancer.

Rhizoma Phragmitis: sweet, cold.Return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis. Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.

Flos Chrysanthemi is pungent, sweet, bitter, is slightly cold, function: dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing.Evacuate Effect Herba Tagetis Patulae rushed down clearly is relatively strong, and Flos Chrysanthemi is held concurrently can nourishing the liver.The present invention uses Flos Chrysanthemi, is usually used in diseases caused by exogenous pathogenic factor Wind heat or epidemic febrile disease from the beginning of and the sick treatment such as excessive rising of liver-YANG, liver-fire mesh disease, hot carbuncle toxin.Flos Chrysanthemi is again Claim Flos Chrysanthemi, be the traditional cultivation medicinal plants of China, be one of Zhejiang Province eight your name's medical material " eight Zhe's ", Also it is best one kind in chrysanthemum scented tea.Prove through modern medicine reason: it has dysentery relieving, antiinflammatory, bright Mesh, blood pressure lowering, blood fat reducing, the effect kept fit.Can be used for treating jaundice due to damp-heat, stomachache lack of appetite, edema oliguria Deng disease.Take a shower with chrysanthemum soup, have the function of itch refreshing body, cosmetology.

Radix Puerariae sweet in the mouth, pungent, cool in nature.Attach to the lung and stomach meridians.Effect expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, Yang invigorating antidiarrheal.Cure mainly and generate heat for exterior syndrome, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, Diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen." Bencao Jingshu ": " Radix Puerariae, dismisses the positive bright main medicine of epidemic febrile disease pathogenic heat also, Therefore master quenches one's thirst, high fever of the body, heat is stopped up chest and diaphragm and is vomitted.Dissipating and rise, the property of wind medicine also, therefore leads all numbness." " wound The double stiffness of the nape pain along the spinal column of cold headache, and bone pain person all over, it is bright that heresy does not still enter sun to the foot sun yet, therefore demonstrate,proves without thirsty, Should not take." " book on Chinese herbal medicine converges and says ": " Radix Puerariae, fresh breeze is cold, clean pathogenic factor in the exterior, expelling pathogenic factors from muscles heat, only excessive thirst.Rush down stomach The medicine of fire is also.Tasting sight and deliver the medicine dissipating heresy, its product are the most, and as Herba Ephedrae is pulled out, sun battalion point is to tremble with fear, Ramulus Cinnamomi solution The wind that the sun is defended point, Radix Saposhnikoviae, Folium Perillae dissipate the sun wind and cold at table, and it is cold at table that Rhizoma Ligustici, Rhizoma Et Radix Notopterygii dissipate the sun Wet, all claim to dissipate medicine also, and dissipating of Radix Puerariae, also enter the sun, also dispersing wind and cold, different again, if non- Fiber crops, osmanthus, revive, anti-, pungent fragrant warm-dryness syndrome, dissipate and damage the mistake of middle gas also；If non-Rhizoma Ligustici, Rhizoma Et Radix Notopterygii, Dissipate and have the anxiety of consumption nutrient blood also." " herbal classic ": quench one's thirst, high fever of the body, vomiting, all numbness, plays the moon Gas, solves all poison.

The gentle lung qi of the Radix Stemonae.Abnormal rising of lung-QI then asthma and cough, the Radix Stemonae bitter and under let out, kind sending down the abnormal ascending QI, so energy Enough therapeutic method to keep the adverse QI flowing downwardss dissipate lung-heat, main warming the lung.For the disease such as lung cold cough, pulmonary tuberculosis.Heat radiation is induced sweat.The Radix Stemonae moistens And the driest, can using pungent drugs for dispersion and bitter drugs for purgation sending down the abnormal ascending QI, clearing away lung-heat and induce sweat, for skin scabies, eczema, psoriasis, all over The diseases such as general edema with yellowish skin, dermatitis, eczema.Parasite killing delousing.Record, hundred according to Qing Dynasty's medical science ancient books and records " book on Chinese herbal medicine is newly organized " Portion's parasite killing and QI and blood is not lost, most useful for people, but during parasite killing, requirement is the biggest, could be effective. Simultaneously can reduce the damage to the intestines and stomach of the Radix Stemonae bitter in the mouth with the compatibility such as Radix Ginseng, Poria, the Rhizoma Atractylodis Macrocephalae.Outer for head The diseases such as louse, body louse, pinworm, pudendal pruritus, ascariasis.

Cortex Magnoliae Officinalis acrid in the mouth, warm in nature, there is effect of circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma.Cortex Magnoliae Officinalis is decocted Agent has stronger antibacterial action to staphylococcus, streptococcus, bloody dysentery bacillus, pasteurellosis bacillus, vibrio cholera； And also have certain mitigation to striped muscle is tetanic.Bark, root bark, flower, seed and bud all can enter Medicine, based on bark, for famous Chinese medicine, have removing dampness intestinal stasis relieving, circulation of qi promoting to relieving asthma, relieving dyspepsia expectorant, wind dispelling town The effect of pain；Seed has improving eyesight QI invigorating effect, and bud is used as gynecological drug

Cortex Phellodendri bitter in the mouth, cold in nature.Kidney, bladder warp.Function has heat clearing and damp drying, and pathogenic fire purging is except steaming, and removing toxic substances is treated Effect of skin ulcer.Cure mainly for damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, tinea pedis flaccidity Preesed, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For Hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.

Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), has another name called ripe Radix Rehmanniae or throw oneself on the ground, the processed process of preparing Chinese medicine forms.Generally with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant through repeatedly steaming solarization, Glossy to inside and outside darkish complexion, quality softness is sticky.Section use, or parch to black use.Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or volt Ground, belongs to goatweed, is a kind of first-class Chinese crude drug, has YIN nourishing effect of enriching blood, can be used for blood deficiency and wither Huang, dizziness, palpitation and insomnia, menoxenia, the disease such as metrorrhagia, also can be used for deficiency of kidney yin hectic fever hectic fever due to YIN-deficiency, Night sweat, pass out semen, the disease such as quench one's thirst, be one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.

Rhizoma Alismatis nature and flavor: sweet, cold.Gui Jing: enter kidney, bladder warp.Effect: diuretic, eliminating dampness by diuresis, expel the heat-evil. Control dysuria, edema distension, vomiting, dysentery, phlegm retention, tinea pedis, gonorrhea, hematuria.Herbal classic ": Main anemofrigid-damp arthralgia, breast is difficult, and disappear water, supports the five internal organs, physical strength profiting, and fertilizer is strong." not Lu ": tonifying deficiency five kinds of over strain, Except the five internal organs feeling of fullness, playing cloudy gas, stopping leak is smart, quench one's thirst, drench drip, cuts off the water by bladder, three Jiao." property of medicine opinion ": Main essence of suffering from a deficiency of the kidney, from going out, controls five types of stranguria, profit bladder heat, straight through water passage.

Borneolum Syntheticum, have another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., be through steam distillation by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf And recrystallization and obtain.The most useful Oleum Terebinthinae obtains through a series of chemical method techniques.It can be used for excess syndrome of stroke god Dusk, for conjunctival congestion and swelling pain, sore throat aphtha, swell and ache for skin infection, do not hold back after bursting.

Specific embodiment 1

The present invention takes the preparation of granule orally:

By Cortex Moutan 1200g, Exocarpium Citri Rubrum 1100g, Rhizoma Dioscoreae 1200g, Semen Cuscutae 1200g, Radix Stemonae 1200g, thickness Piao 1200g, Radix Bupleuri 1100g, Radix Isatidis 1100g, Radix Glycyrrhizae 1200g, Radix Platycodonis 1200g, Semen Oroxyli 1200g, Poria 1200g, Rhizoma Anemarrhenae 1100g, Fructus Corni 1200g, Cortex Mori 1200g, Radix Trichosanthis 1100g, spend in vain Herba Hedyotidis Diffusae 1200g, Cortex Phellodendri 1100g, Radix Paeoniae Rubra 1200g, Radix Rehmanniae Preparata 1200g, Fructus Arctii 1100g.Add and account for it Soak with ethanol 2-3 hour of quality 7-10 times, heating extraction 2 times, each 1-2 hour, united extraction liquid, Taking supernatant after standing, then 100-120 mesh filters, then the ultrafiltration that molecular weight is 5000-10000 through damming Post ultrafiltration, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C.Again by above-mentioned ethanol extraction The medicinal residues of the crude drug crossed add 10 times amount water, heating and refluxing extraction 2 times, each 1～2 hour, carry 2 times Take liquid and merge standing, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, mix two kinds and carry Taking filtrate to insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, puts 0～5 DEG C of deepfreeze 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is put again Enter in economic benefits and social benefits vacuum concentrator, be concentrated into every 1ml crude drug amount Han 0.1g, then add dextrin and make granule.

Specific embodiment 2

Present invention honey for oral administration refining pill:

By Cortex Moutan 1100g, Exocarpium Citri Rubrum 1100g, Rhizoma Dioscoreae 1200g, Semen Cuscutae 1200g, Radix Stemonae 1200g, thickness Piao 1200g, Radix Bupleuri 1100g, Radix Isatidis 1100g, Radix Glycyrrhizae 1200g, Radix Platycodonis 1200g, Semen Oroxyli 1200g, Poria 1200g, Rhizoma Anemarrhenae 1100g, Fructus Corni 1200g, Cortex Mori 1200g, Radix Trichosanthis 1200g, spend in vain Herba Hedyotidis Diffusae 1200g, Cortex Phellodendri 1100g, Radix Paeoniae Rubra 1200g, Radix Rehmanniae Preparata 1200g, Fructus Arctii 1100g..Chopping Being soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stirs Mix uniformly, moistening airtight placement more than 1 hour, make fully to expand；By filter plate gauze bottom percolator Drug sample after moistening expansion is mixed pine and is done to dissipate by bag parcel again after paving, then contain powder with rustless steel spoon, Load percolator uniformly, fill 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, one layer one The loading of layer, suitably pressurizes, and medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover is stainless Steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% second Alcohol liquid；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, Cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g Medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into reservoir Cylinder；Percolate is merged and stands, stand for standby use；The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, When being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；By cold preservation The filter aid kieselguhr that liquid adds 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, adds Mel and is twisted into pill.

Specific embodiment 3

The preparation method of external spraying agent:

Radix Angelicae Dahuricae 1100g, Herba Menthae 1300g, the Borneolum Syntheticum 1300g way of distillation are vaporized into crystallization, pulverize stand-by, For component 1；Other raw materials Radix Stemonae 1200g, Cortex Moutan 1100g, Rhizoma Alismatis 1200g, Fructus Momordicae 1200g, plate Blue root 1200g, Radix Clematidis 1300g, by soak with ethanol, heated and boiled 3 times, each 1-2 hour, filter, Filtrate is standby；By in the filtrate suction concentrating under reduced pressure tank merging latter 3 times, being evaporated to relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C；Become component 2, blending ingredients 1 and component 2, then with Citrullus vulgaris Frost 1200g, mediation substrate, load in aerosol apparatus.

Specific embodiment 4

The preparation method of the liniment of external is

Radix Angelicae Dahuricae 1100g, Herba Menthae 1300g, the Borneolum Syntheticum 1300g way of distillation are vaporized into crystallization, pulverize stand-by, For component 1；Other raw materials Radix Stemonae 1200g, Cortex Moutan 1100g, Rhizoma Alismatis 1200g, Fructus Momordicae 1200g, plate Blue root 1200g, Radix Clematidis 1300g are soaked to be placed in lid stainless steel cask, adds 70% ethanol, matter Amount, for coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand； After filter plate gauze bag parcel is paved bottom percolator, the drug sample after moistening expansion is mixed pine lane again Dissipate, then contain powder with rustless steel spoon, load percolator uniformly, fill 10-12 cm thick, use T-bar pressure Even, then press aforesaid operations, loading in layer, suitably pressurize, medicated powder loads and must not exceed percolator 2/3 eminence；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts one Container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol stream Go out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and ooze Filtering, control percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, And pour ethanol during emptying into liquid container；Percolate is merged and stands, stand for standby use；By filter Filtrate is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, set to 0～ 5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted again In economic benefits and social benefits vacuum concentrator, it is concentrated into every 1ml crude drug amount Han 0.1g, for component 2.By component 1 and component 2 Merging, add watermelon crystal 1200g be in harmonious proportion substrate, sterilizing bottling cold preservation.

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding. Medicine: oral capsule of the present invention.

Two, method:

1, LD50 calculates: use improvement karber's method, mice is randomly divided into 5 groups, often group 10, Male and female half and half, dissolve suppository, are made into Cmax, are administered by the maximum allowable capacity of mice, given agent Amount is followed successively by 18 by crude drug amount, and 14.4,11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) 18 After hour, it is administered (interval half an hour), each 0.5ml in one day at twice, treats animal dead situation.

2, maximum tolerated dose measures (MTD value): take mice 20, each 10 of male and female.By suppository Adding distilled water to dissolve, be made into maximum concentration, by the maximum tolerated dose of animal, filling hello device with injection can twitch It is as the criterion.After animal fasting (can't help water) 18 hours, it is administered at twice in one day (interval half an hour), often Secondary 0.5ml (every ml 0.36g Han crude drug), total dose is 18g crude drug/kg.d, quite clinical adult 50Kg 300 times of body weight consumption.Treat 7 days continuously after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no dead mouse, i.e. do not measure LD50, seek maximum tolerated dose only, at 7 days Treating interim, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, have no There is death.I.e. select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show urgency Property toxicity is minimum, MTD ＞ 18g/Kg.d.

Test example 2: acute skin irritation test of the present invention is reported

1, experiment purpose: detect the spray of the present invention stimulation/corrosiveness to laboratory animal skin with strong Degree

2, material and method:

2.1. tested material: title: spray of the present invention (embodiment 3 method prepares)

2.2. laboratory animal: one grade of big ear white race rabbit, 10, female, body weight 2.1-2.3kg；By green grass or young crops Island University Medical College biology department Experimental Animal Center provides；

2.3. test method:

Select the healthy rabbits 10 that skin is intact, in testing first 24 hours by its spinal column both sides, back quilt Hair is cut, and removes the left and right each about 4cm × 4cm of gross area.Take tested material 0.2ml during test and be applied to 2.5cm On two layers of gauze of × 2.5cm, being applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape. Opposite side skin is as blank.After closing 4 hours, dismantle, and go residual with warm water cleaning Staying tested material, position dermoreaction is smeared in the treatments in 1,24 and 48 hours after removing tested material, and Scoring.

3, experimental result: any erythema does not occurs in laboratory animal skin, red and swollen, inflammation phenomenon.

4, brief summary: judge according to skin wound repair standards of grading in " disinfection technology standard " (1999), Ointment of the present invention belongs to nonirritant to animal skin stimulus intensity.

Pharmacological experiment

Chronic pharyngitis refers to by the pharyngeal pathological changes of the diffusivity caused by chronic infection, multiple is born in adult, It is often accompanied by other upper respiratory diseases, often stings because of the pus of acute pharyngitis recurrent exerbation, rhinitis, sinusitis Swash pharyngeal, or nasal obstruction and mouth breathings etc. cause the generation of chronic pharyngitis.December 1 years 6 in 2013 The moon, the author used oral administration and externally of the present invention to treat chronic pharyngitis (YIN-deficiency type of the lung and kidney) 40 example, obtained preferable treatment Effect, existing report is as follows.

1 clinical data

1.1 physical data 80 examples are the court out-patient, meet chronic pharyngitis diagnostic criteria, at random It is divided into 2 groups.Treatment group 40 example, age 18-65 year.Matched group 40 example, age 19～65 years old；The course of disease All ＞ 6 months.The no significant difference (P ＞ 0. shines) such as 2 groups of ages, sex, state of an illness, have comparable Property.

1.2 diagnostic criteria

1) medical history: often have acute pharyngitis history of repeated attack, or have the long-term mouth breathing of cacorhinia, tobacco and wine excessively, The inducement that surrounding air is dried, dust and irritative gas pollute.2) symptom: pharyngeal discomfort, or pain, Or itch or have dry sensation, burning sensation, sootiness sense, foreign body sensation etc.；Irritable cough, rises and firmly cough morning Go out secretions, even feel sick.The course of disease more than 2 months, Chang Yin suffers from cold, catches a cold, fatigue, polylogia etc. are former Because causing.3) checking: pharyngeal chronic congestion, increase the weight of, in kermesinus, or dendroid is congested；Pharynx rear wall Lymph foilicie hyperplasia, or lateral pharyngeal band enlargement；Pharynx mucosa hypertrophy is plump, or be dried, atrophy, thinning, have Secretions adheres to.Possess above-mentioned symptom and 1 or more than 1 check finding, the most diagnosable.Also to meet Syndrome: pharyngeal dry pain is uncomfortable, burning sensation, foreign body sensation, or the few expectorant of itching throat, heavy towards light dusk, can be with the noon The diseases such as the insomnia of rear hectic fever, fidgets due to deficiency, soreness of the waist and knees, check and see that pharyngeal mucosa is dark red, dry.Belong to lung kidney YIN-deficiency type chronic pharyngitis.

2 Therapeutic Method

2.1 treatment groups use the oral present invention to take orally, prescription: Cortex Moutan 13g, Exocarpium Citri Rubrum 12g, Rhizoma Dioscoreae 12g, Semen Cuscutae 11g, Radix Stemonae 13g, Cortex Magnoliae Officinalis 12g, Radix Bupleuri 13g, Radix Isatidis 11g, Radix Glycyrrhizae 12g, Radix Platycodonis 12g, Semen Oroxyli 13g, Poria 12g, Rhizoma Anemarrhenae 13g, Fructus Corni 11g, Cortex Mori 12g, Radix Trichosanthis 11g, spend in vain Herba Hedyotidis Diffusae 13g, Cortex Phellodendri 12g, Radix Paeoniae Rubra 12g, Radix Rehmanniae Preparata 12g, Fructus Arctii 11g.Make granule (by real Execute example 1 to prepare), three times a day, each bag, take after mixing it with water.

Exterior-applied prescription: watermelon crystal 12g, Radix Angelicae Dahuricae 11g, Radix Stemonae 13g, Herba Menthae 12g, Cortex Moutan 12g, Rhizoma Alismatis 13g, Fructus Momordicae 14g, Borneolum Syntheticum 12g, Radix Isatidis 11g, Radix Clematidis 11g, make spray, external, spray, Blowing or spread on affected part, the most in right amount, every day is for several times.

Matched group: LIUSHEN WAN (Shanghai Leiyun Pharmaceutical Industry Co., Ltd.) is administered orally, and three times a day, warm water is swallowed, Grow up and often take 10.External watermelon crystal spray (Sanjin Pharmaceutical Co., Ltd., Guilin), external, spray, Blow or spread on affected part, the most in right amount, every day for several times, gentamycin 80,000 U (the limited public affairs in Pharmaceutical Jiaozhuo, Tianjin Department) and 20mL normal saline carry out ultrasonic atomizatio (Omron nebulizer NE-c29) Inhalation in Treating, suction The each 20min of the angle of incidence, every day 1 time.All 5d are 1 course for the treatment of, continuously 3 courses for the treatment of of treatment.Observe 2 groups Patient's pharyngeal pain, silent, mucosa is dry and congestion and edema transference cure and alleviate the time.

3 criterions of therapeutical effect and result

Criterion of therapeutical effect is drafted with reference to " hals,Nasen und Ohrenheilkunde diagnostics " criterion of therapeutical effect.Treatment group 40 example, effective 28 examples, effective 11 examples, invalid 1 example, total effective rate is 97.5%；Matched group 40 example, effective 17 examples, have Imitating 11 examples, invalid 12 examples, total effective rate is 70.0%.2 groups of comparing differences statistically significant (P ＜ 0.05).

4 medical record citings

Patient, class, teacher, female, 45 years old, first visit in November, 2013.Main suit: pharyngeal uncomfortable 3 years. Through many places Chinese and western medicine diagnosis and treatment after pharyngitis acute attack before patient half a year, do not heal, then go to a doctor.Disease is seen: Pharyngeal dry pain is uncomfortable, burning sensation, foreign body sensation, or the few expectorant of itching throat, towards weight at light dusk, can with hectic fever in the afternoon, The diseases such as fidgets due to deficiency insomnia, soreness of the waist and knees, check and see that pharyngeal mucosa is dark red, dry.Dream hypersomnia is poor, indigestion and loss of appetite, Two the most still can, red tongue, yellow and thin fur, stringy and thready pulse.Physical examination: isthmus faucium portion is congested, and color is purplish red, pharynx Rear wall is forwardly convex the being dispersed in property lymph foilicie hyperplasia differed in size.Tonsil II degree enlargement, no pus point. Western medicine diagnose: chronic pharyngitis.Tcm diagnosis: sore throat, card belongs to YIN-deficiency type of the lung and kidney.Side's nourishing YIN to lower pathogenic fire, Moisturize sore-throat relieving.For oral administration, prescription: Cortex Moutan 13g, Exocarpium Citri Rubrum 12g, Rhizoma Dioscoreae 12g, Semen Cuscutae 11g, Radix Stemonae 13g, Cortex Magnoliae Officinalis 12g, Radix Bupleuri 13g, Radix Isatidis 11g, Radix Glycyrrhizae 12g, Radix Platycodonis 12g, Semen Oroxyli 13g, Poria 12g, Rhizoma Anemarrhenae 13g, Fructus Corni 11g, Cortex Mori 12g, Radix Trichosanthis 11g, Herba Hedyotidis Diffusae 13g, Cortex Phellodendri 12g, Radix Paeoniae Rubra 12g, Radix Rehmanniae Preparata 12g, Fructus Arctii 11g.Make granule (preparing by embodiment 1), three times a day, Each bag, takes after mixing it with water.

After 10 days, in pharynx, malaise symptoms substantially alleviates, and hawks and significantly reduces, diet, spirit amelioration, all Disease is improved.Successively take traditional Chinese medicine 30 doses, recovery from illness.Follow up a case by regular visits to half a year, without recurrence.

5 discuss

Chronic pharyngitis is the most multiple, and symptom stubbornness is difficult to cure.Pharyngeal sense of discomfort easily makes patient heart not Good, suspicious, the state of an illness, the interaction of both moods, make state of an illness stubbornness complicated, be also one of refractory reason. Primary disease belongs to Chinese medicine " sore throat " category.< Huang di's Canon of Medicine ＞ is loaded with " spleen is too late, then nine orifices is different ". Holy Benevolent Prescriptions is said: " pharynx person swallows also, and sky can swallow thing, the again choke of meaning, main tonneau water paddy, gastric qi Path." say again: " also, speech is wherein hollow, can lead in QI and blood, breathe into lung for throat person's inanition The circulation of gas." " Plain Questions passages through which vital energy circulates another matter " say: " spleen-QI transporting the essence to the whole body, is above attributed to edema caused by the lung disorder essence four cloth, The Five Classics is parallel." say again: " kidney meridian of Foot-SHAO YIN is main kidney disease of viscera connecting with this channel person, the hot dry tongue of mouth, gas on pharyngeal swelling, Dry sensation in the pharynx and pain." as can be seen here, throat and lung, spleen, kidney relation are the closest.The passages through which vital energy circulates of liver " coerce by cloth Rib, after following throat, above enters neck forehead " " Plain Questions QI and blood shape will " is pointed out: " excessive physical exertion and mental depression, Diease occurrence is in pharynx." liver controlling conveyance and dispersion, happiness bar reaches and depressed.The liver failing to maintain the normal flow of QI, depression of liver-QI, perverse and unreasonable manner criminal's spleen, Insufficiency of the spleen dry phlegm-syndrome, mental disorder is handed over and is hindered in throat generation sore throat；The stagnation of QI with the passing of time, then must blood stasis, " prolonged illness must the stasis of blood ", Stagnation of blood stasis is in throat, and sore throat is the most touching.Visible, feelings will Nervous and Mental Factors causes the liver failing to maintain the normal flow of QI to be primary disease Morbidity because of, gas, blood, expectorant, the stasis of blood are the major pathologic features of primary disease, and lung, spleen, renal function are not normal It is only primary disease pathogenesis basis.The traditional Chinese medical science thinks that chronic pharyngitis is many by ferritic YIN-deficiency of the lung and kidney, or acute pharyngitis due to wind-heat is repeatedly Outbreak, remaining heresy is detained unclear, impairment of body fluid consumption liquid, causes consumption of YIN-fluid, and throat loses in moistening foster, furthermore in asthenic fire Disturb, send out as primary disease.Therefore YIN-deficiency type of the lung and kidney chronic pharyngitis is more common type, its disease, pathogenesis, control Method, side's medicine are as follows.

YIN-deficiency of the lung and kidney syndrome: pharyngeal dry pain is uncomfortable, burning sensation, foreign body sensation, or the few expectorant of itching throat, towards light dusk Weight, can check see that pharyngeal mucosa is dark red, dry with diseases such as hectic fever in the afternoon, fidgets due to deficiency insomnia, soreness of the waist and knees Dry.Primary disease pathogenesis: lung kidney consumption of YIN-fluid, throat loses in moistening foster；Hyperactivity of fire caused by deficiency of YIN, asthenic fire is disturbed, and refines Tianjin Become expectorant；YIN-fluid being insufficient, asthenic fire disturbs the heart, so that all Symptoms of YIN-deficiency of the lung and kidney.Method for the treatment of: YIN nourishing drops Fire, moisturizes sore-throat relieving.

Claims

1. the Chinese medicine composition treating YIN-deficiency type of the lung and kidney chronic pharyngitis, it is characterised in that in described Drug composition is made up of with external used medicine endo-medicine, and endo-medicine includes the raw material of following parts by weight Medicine: Cortex Moutan 10～20 parts, Exocarpium Citri Rubrum 10～20 parts, Rhizoma Dioscoreae 10～20 parts, Semen Cuscutae 10～20 parts, the Radix Stemonae 10～20 parts, Cortex Magnoliae Officinalis 10～20 parts, Radix Bupleuri 10～20 parts, Radix Isatidis 10～20 parts, Radix Glycyrrhizae 10～20 parts, Radix Platycodonis 10～20 parts, Semen Oroxyli 10～20 parts, Poria 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Fructus Corni 10～ 20 parts, Cortex Mori 10～20 parts, Radix Trichosanthis 10～20 parts, Herba Hedyotidis Diffusae 10～20 parts, Cortex Phellodendri 10～ 20 parts, Radix Paeoniae Rubra 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, Fructus Arctii 10～20 parts.

In described Chinese medicine composition, external used medicine includes the crude drug of following parts by weight: watermelon crystal 10～20 Part, the Radix Angelicae Dahuricae 10～20 parts, the Radix Stemonae 10～20 parts, Herba Menthae 10～20 parts, Cortex Moutan 10～20 parts, Rhizoma Alismatis 10～ 20 parts, Fructus Momordicae 10～20 parts, Borneolum Syntheticum 10～20 parts, Radix Isatidis 10～20 parts, Radix Clematidis 10～20 parts.

Treat the Chinese medicine composition of YIN-deficiency type of the lung and kidney chronic pharyngitis, its feature the most according to claim 1 Being, described endo-medicine also includes the crude drug of following parts by weight: Cortex Moutan 10～15 parts, Exocarpium Citri Rubrum 10～ 15 parts, Rhizoma Dioscoreae 10～15 parts, Semen Cuscutae 10～15 parts, the Radix Stemonae 10～15 parts, Cortex Magnoliae Officinalis 10～15 parts, bavin 10～15 parts recklessly, Radix Isatidis 10～15 parts, Radix Glycyrrhizae 10～15 parts, Radix Platycodonis 10～15 parts, Semen Oroxyli 10～ 20 parts, Poria 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Fructus Corni 10～20 parts, Cortex Mori 10～20 parts, Radix Trichosanthis 10～20 parts, Herba Hedyotidis Diffusae 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Paeoniae Rubra 10～20 parts are ripe 10～20 parts of ground, Fructus Arctii 10～20 parts.

Described external used medicine also includes the crude drug of following parts by weight: watermelon crystal 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, the Radix Stemonae 10～15 parts, Herba Menthae 10～15 parts, Cortex Moutan 10～15 parts, Rhizoma Alismatis 10～20 parts, Fructus Momordicae 10～20 parts, Borneolum Syntheticum 10～20 parts, Radix Isatidis 10～20 parts, Radix Clematidis 10～20 parts.

Treat the Chinese medicine composition of YIN-deficiency type of the lung and kidney chronic pharyngitis, its feature the most according to claim 1 Being, described endo-medicine also includes the crude drug of following parts by weight: Cortex Moutan 10～20 parts, Exocarpium Citri Rubrum 10～ 20 parts, Rhizoma Dioscoreae 10～20 parts, Semen Cuscutae 10～20 parts, the Radix Stemonae 10～20 parts, Cortex Magnoliae Officinalis 10～20 parts, bavin 10～20 parts recklessly, Radix Isatidis 10～20 parts, Radix Glycyrrhizae 10～20 parts, Radix Platycodonis 10～20 parts, Semen Oroxyli 10～ 15 parts, Poria 10～15 parts, the Rhizoma Anemarrhenae 10～15 parts, Fructus Corni 10～15 parts, Cortex Mori 10～15 parts, Radix Trichosanthis 10～15 parts, Herba Hedyotidis Diffusae 10～15 parts, Cortex Phellodendri 10～15 parts, Radix Paeoniae Rubra 10～15 parts are ripe 10～15 parts of ground, Fructus Arctii 10～15 parts.

Described external used medicine also includes the crude drug of following parts by weight: watermelon crystal 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, the Radix Stemonae 10～20 parts, Herba Menthae 10～20 parts, Cortex Moutan 10～20 parts, Rhizoma Alismatis 10～15 parts, Fructus Momordicae 10～15 parts, Borneolum Syntheticum 10～15 parts, Radix Isatidis 10～15 parts, Radix Clematidis 10～15 parts.

4. as according to any one of claims 1 to 3, treat YIN-deficiency type of the lung and kidney chronic pharyngitis Chinese drug-treated group for one kind The preparation method of compound, it is characterised in that described endo-medicine is that the preparation method of granule includes following Step:

A. the extraction of raw material medicinal alcohol is taken, as component 1；

The system of the endo-medicine granule for the treatment of YIN-deficiency type of the lung and kidney chronic pharyngitis the most according to claim 4 All crude drug are shredded, are soaked and be placed in by Preparation Method, it is characterised in that in described step a In lid stainless steel cask, adding 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening close Close placement more than 1 hour, make fully to expand；By bottom percolator filter plate gauze bag parcel pave after again Drug sample after moistening expansion is mixed pine do to dissipate, then contain powder with rustless steel spoon, load percolation uniformly Cylinder, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, loading in layer, suitably Pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and beats Open the baiting valve below percolator, and put a container, be then slowly added into 70% ethanol；Medicine to be discharged Air between powder powder, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, leaching Stain 24 hours, then opens baiting valve and carries out percolation, and it is per minute that control percolation speed is generally 1000g medical material Flowing out 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；By diafiltration Liquid merges standing, and stand for standby use, as component 1.

The system of the endo-medicine granule for the treatment of YIN-deficiency type of the lung and kidney chronic pharyngitis the most according to claim 4 Preparation Method, it is characterised in that in described step b, puts into 10 times amount by above-mentioned stripped raw material residue In water, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, and ultrafiltrate decompression is dense The filtrate of 1.05 when contracting relative density is 80 DEG C, as component 2.

The system of the endo-medicine granule for the treatment of YIN-deficiency type of the lung and kidney chronic pharyngitis the most according to claim 4 Preparation Method, it is characterised in that in described step c, by 2-in-1 also to component 1 and component, concentrating under reduced pressure is the closeest The filtrate of 1.38 when degree is 70 DEG C, reclaims ethanol, by gained filtrate adjustment proportion to 1.60, is passed through spraying Drying machine is spray-dried, and the compressed air pressure crossing spray dryer shower nozzle is 4kg/m², hothouse Hot stream temperature is 100 DEG C, obtains raw material medicated powder, is dried to powder, adds dextrin and makes granule.

8. as according to any one of claims 1 to 3, treat YIN-deficiency type of the lung and kidney chronic pharyngitis Chinese drug-treated group for one kind The preparation method of compound, it is characterised in that the external preparation of described Chinese medicine composition is spray, its system Preparation Method is following steps:

The medicine for external use of the Chinese medicine composition for the treatment of YIN-deficiency type of the lung and kidney chronic pharyngitis the most according to claim 4 The preparation method of the spray of thing, it is characterised in that in described step a, first by the crude drug Radix Angelicae Dahuricae, thin Lotus, Borneolum Syntheticum steam method distill, and obtain crystal, then pulverize, cross 100-120 mesh sieve, as group Point 1 standby.

The external of the Chinese medicine composition for the treatment of YIN-deficiency type of the lung and kidney chronic pharyngitis the most according to claim 4 The preparation method of the spray of medicine, it is characterised in that in described step b, by except remaining of watermelon crystal Crude drug is put in 10 times amount ethanol, soaks 1-2 hour, and heating extraction 2 times each 1-2 hour, takes Clear liquid, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post that molecular weight is 5000-10000 through damming Ultrafiltration, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 2；By Citrullus vulgaris Frost is put in component 1 component 2, stirs, solubilizer, loads in aerosol apparatus, and the present invention does not contains anticorrosion Agent, must cold preservation.