CN106038451A

CN106038451A - Traditional Chinese medicine eye cream capable of relieving pouches and preparation method thereof

Info

Publication number: CN106038451A
Application number: CN201610451728.5A
Authority: CN
Inventors: 杨高林
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-06-21
Filing date: 2016-06-21
Publication date: 2016-10-26

Abstract

The invention relates to a traditional Chinese medicine eye cream capable of relieving pouches. The traditional Chinese medicine eye cream is prepared from the following raw medicinal materials in parts by weight: 10-20 parts of rhus chinensis, 10-20 parts of radix phytolaccae, 10-20 parts of euphorbia kansui, 10-20 parts of notopterygium root, 10-20 parts of myrrh, 10-20 parts of root of red-rooted salvia, 10-20 parts of peach kernels, 10-20 parts of pseudo-ginseng, 10-20 parts of rhizoma phragmitis, 10-20 parts of safflower carthamus, 10-20 parts of radix sanguisorbae, 10-20 parts of rhizoma bletillae, 10-20 parts of herba menthae, 10-20 parts of borneol, 10-20 parts of radix angelicae, 10-20 parts of frankincense, 10-20 parts of rhizoma alismatis, 10-20 parts of ground beeltle, 10-20 parts of coptis chinensis and 10-20 parts of sophora fruit. The traditional Chinese medicine eye cream refers to pharmacological research achievements of ancient and modern traditional Chinese medicine, and the natural traditional Chinese medicines capable of tonifying qi and activating blood, clearing liver and improving vision, nourishing liver and tonifying kidney, removing nebula, calming the liver and suppressing yang, clearing away heat and toxic materials, subsiding swelling and removing water are screened, so that the traditional Chinese medicine eye cream has the functions of strengthening the body resistance to eliminate pathogenic factors, relaxing bowels and removing toxins, activating blood and eliminating stagnant blood.

Description

A kind of Chinese medicine eye cream alleviating eye pouch and preparation method thereof

Technical field

The present invention relates to, containing the beauty treatment preparation deriving from plant, animal or mineral component, alleviate particularly to one Chinese medicine eye cream of eye pouch and preparation method thereof.

Background technology

Everybody has a love of beauty, can hang a big eye pouch estimates it is that whose mood is the most bad on the face.Eye pouch is that one is begged for very much The athero detested, it has a strong impact on the attractive in appearance of people, has the people of eye pouch to seem senile, and eye pouch refers to that lower eyelid portion organizes Too fat to move, take the shape of a bag and hang from above.In frame, fat content and the supportive structure of lower eyelid maintain poised state under normal circumstances, when this flat When weighing apparatus changes owing to capsula adiposa bulbi accumulation is too much or lower eyelid support structure thin is weak, capsula adiposa bulbi breaks through the restriction of lower eyelid Protrude from outside socket of the eye, i.e. form the bag-shaped deformity of lower eyelid.Clinical manifestation is that skin of lower eyelid is lax, piles up, capsula adiposa bulbi abjection hang from above in Bag-shaped, outer canthus position moves down, and lower margo palpebrae is not tight with eyeball laminating, and lower margo palpebrae radian increases, and moves the tear that overflows, face bone outside lower lacrimal point The aging absorption of bone causes lower eyelid support structure secondary to relax, and is the main cause of person in middle and old age's eye pouch formation.

Eye pouch is caused due to cutis laxa.This understanding has the biggest representativeness.Through demonstration, also it is that eye pouch produces Raw main cause.So, promoting skin tightness is main improvement approach.More satisfactory mode is oral collagen egg In vain.But do not extravagantly hope and the most thoroughly improve, because the reparation of eye pouch is to need certain process.

Increasing the weight of of eye pouch is owing to hyperliposis causes.This is also great representational understanding, and Orbital septum fat has it normal Physiological function, its major function be protection eyeball.The most also it is one of reason forming eye pouch.Why form " pouch sample " Outward appearance, entirely due to caused by the hypotonia of socket of the eye barrier film.The minimizing technology of this eye pouch is just by liposuction of performing the operation.If hands After art liposuction, and not carrying out the reparation of socket of the eye barrier film, consequence inevitably results in eye pouch recurrence.If taking out fat in a large number, that is inevitable Cause the depression of lower eyelid, increase the weight of aged appearance.

Cosmetics can rescue eye pouch.This to analyze in terms of two, if " functional " eye pouch, say, that eye pouch Time and obvious, time and inconspicuous.Suitably applied nutrition frost class cosmetics are to play a role for preventing eye pouch from increasing the weight of 's.And once eye pouch is " pathologic ", namely organizational structure there occurs change, and eye pouch manifests for a long time, and gradually adds Weight.If one want to cosmetics are corrected, that is entirely futile effort.Eyes maintenance must be carried out in advance, the few disease of eye pouch depolarization The outer physiologic factor of rational factors accounts for the overwhelming majority, and a large amount of women ignore the demand to eyes maintenance in the case of health, After causing starting aging occurs, speed is very fast, and conscious before aging to carry out maintenance extremely important.

Occurring and increasing the weight of of eye pouch is one of old and feeble mark of skin of face.Want to avoid completely the generation of eye pouch, be not Reality is also impossible.Because aging is the natural law, it is overpowering.But as long as noting a little, it is to be entirely possible to Delay and prevent the generation of eye pouch.

Cause eye pouch and have six reasons

1, spleen and stomach function weakens, and can cause internal hydrops, causes palpebra inferior to relax, forms eye pouch.

2, liver is one of toxin expelling and hemopoietic system, liver opening at eye, and the problem of liver shows at eyes entirely, if liver cannot be arranged Detoxicating element, will form eye pouch.

3, suffer from a deficiency of the kidney body fluid metabolic obstacle can occur, deficiency of kidney-QI, with the passing of time cause QI and blood smooth, eye pouch occurs.

4, from the point of view of the science of channels and collaterals, palpebra inferior walks stomach warp, and the position of eye pouch is Tongzi point and the SIBAI point place of stomach warp.Body fluid There is decline in metabolic function, and stomach function is deteriorated, and makes Tongzi point and SIBAI point obstruction be caused.

5, the blood circulation of circumference of eyes easily becomes because of overwork to be retarded by silt, and blood vessel refluxes not smooth owing to silting up, causes Lymph metabolism slows down, and makes unnecessary moisture and accumulation of blood below eyes, then forms eye pouch.

6, skin hydropenia is serious, and each cell of skin is required for enough nutrients, when skin does not has enough water for a long time When molecule is propped up, also result in the lax of skin change, cause eye pouch occur or increase the weight of.

Theory of Chinese medical science think major part eye edema generation relevant with Liver and kidney void, after Liver and kidney void, kidney essense can not nourishing the liver blood, And " liver opening at eye ", finally lose because of essence and blood, show and on eyes, be formed for black eye, ocular edema.And modern study is also Confirm that eye edema is owing to often staying up late, emotional instability, eye strain, aging, cause vein blood vessel blood flow rate excessively Slowly, eye part skin red blood cell is for hypoxgia, and in vein blood vessel, carbon dioxide and metabolic waste accumulation too much, are formed chronic Anoxia, blood is dark and forms delay and causes eye pigmentation, and eye edema.This is to match with theory of Chinese medical science 's.Eye pouch can pass through operative correction.Laser also can improve eye pouch, promotes the metabolism of skin, promotes the circulation of blood, pouring Ba Xunhuan, makes the desalination slowly of deep eye pouch, and about course for the treatment of just can be appreciated that obvious laser beautifying removes eye pouch later Effect.Laser goes eye pouch to be belonging to noinvasive beauty treatment, it is not necessary to anesthesia, and laser goes eye pouch other can have office after administering the treatment The phenomenon that portion is red and swollen, this belongs to normal phenomenon, if the nursing of circumference of eyes of working good and daily maintenance, effect can be more Lasting, but expensive, and have certain risk, be not everyone rising of can bearing.

Summary of the invention

The technical problem to be solved is, along with the growth at age, spleen and stomach function weakens, and can cause internal long-pending Water, causes palpebra inferior to relax, forms eye pouch；Liver opening at eye, the problem of liver shows at eyes entirely, if liver cannot clear poison Element, will form eye pouch.Suffer from a deficiency of the kidney and body fluid metabolic obstacle can occur, deficiency of kidney-QI, with the passing of time cause QI and blood not smooth, eye pouch occurs.

Though clinical laser has certain curative effect, but expensive, there is side effect in various degree or cause some complication；And Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoys favor.But Existing prescription specific aim is poor, it is impossible to fundamentally alleviate eye pouch, and the most certain side effect.Therefore, a kind of height is found The Chinese medicine eye cream of effect safety becomes the urgent needs of people.

For solving these technical barriers, the invention provides a kind of Chinese medicine eye cream alleviating eye pouch, its described Chinese medicine eye cream In can include the crude drug of following parts by weight: Fructus rhois chinensis 10～20 parts, Radix Phytolaccae 10～20 parts, Radix Kansui 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Myrrha 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Semen Persicae 10～20 parts, Radix Notoginseng 10～20 parts, Rhizoma Phragmitis 10～20 parts, red Spend 10～20 parts, Radix Sanguisorbae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, Rhizoma Alismatis 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Rhizoma Coptidis 10～20 parts, the Fructus Sophorae 10～20 parts.

The Chinese medicine eye cream of described alleviation eye pouch, can also include the raw material of following parts by weight in its described Chinese medicine eye cream Medicine: Fructus rhois chinensis 10～15 parts, Radix Phytolaccae 10～15 parts, Radix Kansui 10～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Myrrha 10～15 parts, Radix Salviae Miltiorrhizae 10 ～15 parts, Semen Persicae 10～15 parts, Radix Notoginseng 10～15 parts, Rhizoma Phragmitis 10～15 parts, Flos Carthami 10～15 parts, Radix Sanguisorbae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, Rhizoma Alismatis 10～20 parts, soil Trionyx sinensis Wiegmann worm 10～20 parts, Rhizoma Coptidis 10～20 parts, the Fructus Sophorae 10～20 parts.

The described Chinese medicine eye cream slowly solving eye pouch, can also include the raw material of following parts by weight in its described Chinese medicine eye cream Medicine: Fructus rhois chinensis 10～20 parts, Radix Phytolaccae 10～20 parts, Radix Kansui 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Myrrha 10～20 parts, Radix Salviae Miltiorrhizae 10 ～20 parts, Semen Persicae 10～20 parts, Radix Notoginseng 10～20 parts, Rhizoma Phragmitis 10～20 parts, Flos Carthami 10～20 parts, Radix Sanguisorbae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Herba Menthae 10～15 parts, Borneolum Syntheticum 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Olibanum 10～15 parts, Rhizoma Alismatis 10～15 parts, soil Trionyx sinensis Wiegmann worm 10～15 parts, Rhizoma Coptidis 10～15 parts, the Fructus Sophorae 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for the preparation method of a kind of Chinese medicine eye cream alleviating eye pouch, its institute State preparation method to comprise the following steps:

A. take Herba Menthae, Myrrha, Rhizoma Et Radix Notopterygii, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae and the Borneolum Syntheticum way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, As component 1；

B. surplus stock medicinal alcohol is extracted, merge concentrated extracting solution；

C. stripped for above-mentioned steps ethanol extracting solution is condensed into extractum, as component 2；

D. adding substrate with component 2 after component 1 being mixed to be in harmonious proportion, sterilize tinning.

In described step a, can first crude drug Herba Menthae, Myrrha, Rhizoma Et Radix Notopterygii, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae be steamed with Borneolum Syntheticum steam method Evaporate, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.

In described step b, remaining crude drug can be shredded, be soaked and be placed in lid stainless steel cask, add 70% second Alcohol liquid, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By percolator Drug sample after moistening expansion is mixed pine after paving and is done to dissipate by bottom filter plate gauze bag parcel again, then contains with rustless steel spoon Powder, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer is suitable Working as pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens under percolator The baiting valve in face, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have second Alcohol flows out about about 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation Speed is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and pours ethanol during emptying into storage Fluid cylinder；Percolate is merged and stands, stand for standby use.

In described step c, the extracting solution that above-mentioned steps can be extracted, put in economic benefits and social benefits vacuum concentrator and mix, first will When filtrate is concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；Cold preservation liquid is added 0.3% Filter aid kieselguhr, filter, filtrate inserts in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1m1 extractum Han 0.1g, one-tenth component 2.

In described step d, component 1 can be put in component 2, stir, heating, mediation substrate, become cream.

In described step d, described substrate is selected from: propolis, Tween-80, triethanolamine, propylene glycol, semi-synthetic fat One or more in acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

The Chinese medicine eye cream of described alleviation eye pouch, its using method is, the most just before going to bed after face cleaning, by eye cream uniform application in Near the eyes, and massaging near the eyes 15-20 minute by middle finger finger belly, after fully absorbing to it, getting up early in second day washes away.

The present invention, with reference to the achievement of Chinese medicine pharmacological research at all times, screens inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving eyesight Nebula removing, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence are let out poison, promoting blood circulation to remove blood stasis, are regulated human body except the natural Chinese medicine of water, strengthening vital QI to eliminate pathogenic factors, purging FU-organs Metabolism function, improve human body periocualr skin blood circulation, thus reach subside a swelling blood stasis dispelling, fatigue alleviating, compact eye flesh Skin.Desalination eye pouch, beautifies the purpose of appearance.The present invention is according to Traditional Chinese medical theory and modern pharmacological research result, repeated screening Medicine for external use, is configured to Chinese medicine eye cream, has blood circulation promoting and blood stasis dispelling, improving acuity of vision and removing nebula, temperature promoting blood circulation, and skin-active is subsided a swelling, and blood-nourishing and freckle-removing, compact flesh Effect of skin.Can effectively expand peripheral vessel, improve face microcirculation near the eyes, blood stasis dispelling of subsiding a swelling, pigmentation is had certain pressing down Make and use.Therapeutic effect of the present invention is more satisfactory, and non-toxic and safe, and preparation method is simple and easy to do, can create good social benefit With economic benefit.

Detailed description of the invention

Cosmetics can rescue eye pouch.This to analyze in terms of two, if " functional " eye pouch, say, that eye pouch Time and obvious, time and inconspicuous.Suitably applied nutrition frost class cosmetics are to play a role for preventing eye pouch from increasing the weight of 's.And once eye pouch is " pathologic ", namely organizational structure there occurs change, and eye pouch manifests for a long time, and gradually adds Weight.If one want to cosmetics are corrected, that is entirely futile effort.Eyes maintenance must be carried out in advance, the few disease of eye pouch depolarization The outer physiologic factor of rational factors accounts for the overwhelming majority, and a large amount of women ignore the demand to eyes maintenance in the case of health, After causing starting aging occurs, speed is very fast, and conscious before aging to carry out maintenance extremely important.Its outstanding guarantor Supporting and can usefulness be formed at skin surface frivolous such as the moistening sebum film of yarn, produce remarkable moistening effect, holding skin youth be wet Profit.

Motherland's medical science is thought, this pathogenetic endogenous cause of ill is dirty with liver,spleen,kidney three and QI-blood circulation not normal in close relations, Therefore treatment by oral administration of medicines is controlled from liver spleen kidney opinion internal organs are many, but is also the external reflection of body interior dysequilibrium.So wanting in treatment From entirety, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Liver spleen essence and blood is full, punching appoints tune smooth, then the money of medicine carrying had by oneself by blood network.Liver controlling conveyance and dispersion, can adjust and reach QI and blood, happy feelings will.If depression of liver-QI, qi-blood disharmony. qi depression to blood stasis.Stop up stagnant channels, on tie and then cause speckle in face.The main Tibetan of liver Blood.Liver blood fill and, then body be good for face profit.If deficiency of the liver and kindey, blood and essence asthenia, it is impossible to upper Rong Ze easy dough speckle.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, gas Blood is with smoothness balance for expensive, if QI and blood is the most smooth will produce blood stasis, blood stasis hinders in internal, will further result in qi-blood circulating Deterioration, cause more serious stasis of blood plug, therefore the traditional Chinese medical science be with QI and blood as guiding principle, be allowed to smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, Nourish blood beauty treatment.Skin speckle basic in the stasis of blood, move back speckle must first blood stasis dispelling, blood stasis dispelling when invigorating blood circulation, invigorate blood circulation more must QI invigorating, regulate the flow of vital energy, gas is The general of blood, blood runs therewith；Blood is keeping of gas, that be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy then blood prostration, and gas is compeled then blood and walked. QI and blood and then all and.And regulate the flow of vital energy liver, QI invigorating is at lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI and blood fortune of lung spleen Liver and kidney Row function, and cause face and the mottles such as chloasma, black eye, eye pouch, eye edema, freckle occur, alopecia, speckle even occur Bald.The present invention mainly identifies and corrects the principle treated according to Chinese medicine, the many doctor chiefs of collection, extensively adopts the strange medicine wonderful recipe in rich receipts area, Skim the cream off milk；Choose inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence except water Natural Chinese medicine, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of regulation human body, is improved human body periocualr skin blood Liquid circulates, thus reaches subside a swelling blood stasis dispelling, fatigue alleviating, eye skin of compacting.Desalination eye pouch, beautifies the purpose of appearance.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing receives antiperspirant.Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous perspiration Night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, benefit woman's blood." solar corona Book on Chinese herbal medicine ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, bring down a fever, relieving restlessness, QI invigorating, the hot disease of sky row, pestilence Miasma, mania and irritation, married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, White person controls blood.

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Tell for hemoptysis Blood, traumatic hemorrhage, sore swollen toxin, chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, evil Skin ulcer, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "；Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping." day China's son book on Chinese herbal medicine ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, row Pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea pain Warp, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen is tied Block, skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc..Treatment costa sternales pain, lump in the abdomen caking, and Menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG is controlled gynecopathy, paid no attention to Antenatal puerperal, how many through water, the most generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peace Green tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has expansion blood vessel, improves circulation, releasing blood vessel Intravascular coagulations etc. act on, and have effect of invigorating blood circulation trace, and can promote that liver blood circulates, beneficially liver cell regeneration.

Herba Menthae, popular name, " lunar caustic grass ", for labiate, i.e. belongs to other dry herbs together, is born in hill wetland river more Side, rhizome grows wild underground, is a kind of fragrant crop having extraordinary economic worth.Herb green grass or young crops gas fragrance.Leaf, to life, is spent little pale purple Color, lip, tie the granule fruit of dark violet brown after spending.Herba Menthae is one of China's conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls Influenza, headache, conjunctival congestion, fever of the body, throat, dental bed such as swell and ache the disease.Place is with can training the mind dysmenorrhoea, skin pruritus, erythra and wet Rash etc..Herba Menthae is China's conventional Chinese medicine, and children's tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, headache, mesh Swelling pain, myalgia, skin rubella scratches where it itches, the disease such as measles without adequate eruption, the most effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains Menthol, this material can fresh breath there is the multiple property of medicine, stomachache, gallbladder problem such as spasm can be alleviated, also there is anticorrosion and kill Bacterium, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion.A large amount of edible Herba Menthaes may result in insomnia, but low dose of eating contributes to sleeping Sleep.

Myrrha (Commiphora myrrha Eng1.), has another name called myrrh, for olive subject plant Herba Violae tree or Ha Didingshu Dry resin.Main product is in Africa Somalia, Ethiopia and India and other places.Gather the white oil oozed out by bark crack Gum resin, becomes rufous and hard nahlock in air.After smashing, fry to coke black application.Cure mainly the chest and abdomen stasis of blood bitterly, bitterly Warp, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.In the Orient Be a kind of invigorate blood circulation, blood stasis dispelling, pain relieving, the Chinese medicine of stomach invigorating, raw property or lymphatic temperament disease, such as raw property arthralgia, ischium god Dysmenorrhoea, oral cavity pain, to have sore throat, cold cough, moist abundant expectoration, bronchiectasis, eczema abscess, menoxenia, urine is not Profit." note doctor allusion quotation ": " hair growing, speckle dispelling disappears trace, and softening the hard mass removes tumor, and except tinea more wound, teeth consolidating is good for gum, removing toxic substances etc..Control alopecia capillary, Black spot bruise, verruca plana, various eczemas, gingiva is rotten to the corn, and poisonous insect stings wound etc.." Myrrha compatibility Flos Carthami, Myrrha promoting blood circulation and stopping pain, Flos Carthami Activating blood and removing stasis stimulates the menstrual flow.Papillary, have invigorate blood circulation, silt of dispelling, stimulate the menstrual flow, effect of pain relieving, with what treatment blood stasis caused by trusted subordinate's pain, Dysmenorrhea, puerperal become silted up and hinder stomachache and the stasis pain of traumatic injury.

Flos Carthami (Classification system: Carthamus tinctorius L.), another name: red blue flower, thorn Flos Carthami, Compositae, Flos Carthami belong to Plant, dry tubular flower, orange red, floral tube is narrow carefully, and tip 5 splits, and sliver is narrow linear, and flower pesticide yellow is unified into pipe, exceeds and split Outside sheet, its central authorities have stigma to expose.Have special fragrance, mildly bitter flavor.To spend, length of a film, color be scarlet, the soft person of matter is preferred.Invigorate blood circulation logical Warp, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the breast side of body twinge, traumatic injury, skin ulcer Infections swells and ache curative effect.Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen.

Borneolum Syntheticum, has another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing Deng, it is to be obtained through steam distillation recrystallization by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf.The most useful Lignum Pini Nodi Oil obtains through a series of chemical method techniques.It can be used for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, swell for skin infection Bitterly, do not hold back etc. after bursting " Newly Revised Canon of Materia Medica ": " main trusted subordinate's pathogen, rheumatism is gathered, deaf, and conjunctival congestion skin nebula is gone in improving eyesight." " book on Chinese herbal medicine guiding principle Mesh ": " treatment sore throat, headache, nose, toothache, typhoid fever protrusion of the tongue, children's's pox fall into.Logical all keys, dissipate stagnated fire." " medical center bun is wanted ": " Borneolum Syntheticum Main scattered stagnated fire, the deep heat of energy, control infantile convulsion, expectorant fan, sore throat, swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, kill Worm, hemorrhoid, expediting the emergence of, property is walked and is not kept, also can granulation promoting pain relieving.

Semen Persicae (Semen Persicae), can refer to the core youngster in Semen Persicae；When using as Chinese herbal medicine Semen Persicae, refer in particular to Rosaceae Plant Fructus Persicae or the seed of Prunus davidiana, call Radix Fici Hirtae core, almond core, big Semen Persicae, and 6～pluck during fruit maturation in July, remove sarcocarp and core Shell, take out seed, dry, have effect of blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, can be used for amenorrhea, dysmenorrhea, abdominal mass mass in the abdomen, injury from falling down, Dryness of the intestine constipation etc..Anemia of pregnant woman is cautious use of.Clinical observation proves, blood flow is blocked by Semen Persicae, blood obstacle has improvement result, can make each internal organs Each tissue functional recovery is normal.

Radix Notoginseng is to be used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has " gold Do not change ", the good reputation of " southern part of the country SHENCAO ".Because season in Chang Chun winter two excavates, it is divided into again " spring seven " and " winter seven ".Qing Dynasty's pharmaceutical texts Described in supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying first, Radix Notoginseng enriches blood first, taste with and merit also etc., therefore claim Panax pseudoginseng, for Most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", i.e. with Radix Notoginseng for primary raw material system Become.Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

Fructus rhois chinensis, latin name Rhus chinensis Mill. is good nectariferous plant.Root, leaf, flower and fruit all can enter Medicine, has the hemostasis of heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis, the effect of relieving diarrhea with astringents.Anacardiaceae plant Fructus rhois chinensis Rhus chinensis Mill. it is used as medicine with root, leaf.Root: be used as medicine for " Radix Rhois chinensis ", has wind dispelling, removing dampness, detumescence, effect of softening the hard mass；Cure cold heating, Cough, diarrhoea, edema, rheumatic arthralgia, traumatic injury wound is swollen, and acute mastitis, tinea skin ulcer, disappear alcoholism.Remove the root bark of cork for " Chinese sumac root is white Skin ", there are wind-damp dispelling, dissipating blood stasis blood, effect of heat-clearing and toxic substances removing；Control cough, rheumatic ostalgia, edema, jaundice, traumatic injury, toxic swelling skin ulcer Scabies, venom etc..

Radix Sanguisorbae (Classification system: Sanguisorba officinalis L.) is that Rosaceae burnet perennial herb is planted Thing, Radix Sanguisorbae is also Chinese herbal medicine.Cold in nature, bitter in the mouth acid, nontoxic；Return liver, lung, kidney and large intestine channel.There are cooling blood for hemostasis, heat-clearing and toxic substances removing, training Clear yin nourishing, the effect such as detumescence sore." herbal classic ": housewife people's seven kinds of impairments, leukorrheal diseases, pain relieving, except disliking meat, hidroschesis, treat incised wound." not Record ": only pus and blood, all flaccidity, malignant boil, disappear wine, except quenching one's thirst, mends exhausted wound, and in puerperal, plug, can make incised wound cream.Main internal hemorrhage due to trauma is more than, and blood is not Foot." property of medicine opinion ": hemostasis dysentery erosion pus.

Olibanum, Chinese medicine name.For olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener The resin that Boswellia bhaurdajiana Birdw. bark oozes out.Compendium of Material Medica: " all poison of eliminating carbuncle cellulitis, Tuoli protects the heart, Invigorate blood circulation analgesic therapy, control married woman's difficult labour, injured." " Olibanum perfume (or spice) is altered, and can enter heart channel, analgesic therapy of invigorating blood circulation, thus be ulcer sores, cardiac and abdominal pain want Medicine.... all sides of obstetrics multiplex it, also take its merit ear invigorated blood circulation." book on Chinese herbal medicine remittance speech ": " Olibanum, promoting blood circulation by removing wind, the medicine of muscles and tendons relaxing to alleviate pain Also.... tumbling down bucket is beaten again, injured muscles and bones, and QI and blood in puerperal attacks thorn again, trusted subordinate's pain, permanent salty take it with this and fragrant pungent wanders away, scattered blood Evacuation of pus, ventilationization is stagnant for special merit also.”

Eupolyphaga Seu Steleophaga, Chinese medicine name.For Corydiidae insecticide eupolyphoge sinensis Eupolyph, aga sin, ensis Walker or Ji eupolyphoge sinensis The female worm dry body of Steleophaga Plancyi (Boleny).There is removing blood stasis, effect of reunion of fractured tendons and bones.For traumatic injury Damage, injury of tendon and muscle fracture, blood stasis amenorrhea, postpartum stagnation stomachache, addiction abdominal mass mass in the abdomen.

Rhizoma Phragmitis is sweet, cold.Gui Jing: return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura Excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis has effect of clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis, Cure mainly calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.During Rhizoma Phragmitis is clear, double ventilative heat, controls cough due to pathogenic wind-heat Available, often join the medicines such as Folium Mori, Flos Chrysanthemi, Radix Platycodonis, with wind and heat dispersing, lung qi dispersing cough-relieving, side such as " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases " SANGJU YIN.

Rhizoma Et Radix Notopterygii Rhizoma Et Radix Notopterygii, another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, Latin literary fame Notopterygium incisum. Umbelliferae, Notopterygium plant, Chinese medicine cures mainly: warm in nature, dispelling cold and dampness, for affection of exogenous wind-cold, head The most lossless, cold-damp numbness, upper limb rheumatalgia.Dissipate exterior cold；Wind-damp dispelling；Profit joint；Pain relieving.Main affection of exogenous wind-cold；Have a headache lossless；Edema due to wind pathogen Edema；Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；External curing vitiligo, Alopecia areata.Relieving exterior syndrome and dispelling cold, expelling wind and dampness, pain relieving.Property of medicine opinion ": " controlling harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, actinal surface is askew more Heresy, insensitive impediment all over." " Japan hanako materia medica ": " controls a wind cutting gas, muscles and bones fist contraction, and extremity are thin bad, the head rotation red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times Aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs.″

Radix Kansui bitter in the mouth；Cold in nature；Poisonous.Spleen channel；Lung meridian；Kidney channel；Bladder warp；Large intestine channel；Small intestine meridian.Removing water retention by purgation, by swollen, is subsided a swelling Eliminating stagnation.Edema；Ascites；Prolonged fluid-retention blocked-up chest；Epilepsy；Breath with cough；Sphincter disturbance." book on Chinese herbal medicine is newly organized ": Radix Kansui, broken disease heavily fortified point accumulation such as god, Move back the edema of the face, water knot in stomach of dispelling, especially can diuretic.This thing is relieved oedema or abdominal distension through diuresis or purgation wet and merit is delayed, and leading a cow, it is wet and merit is fast to relieve oedema or abdominal distension through diuresis or purgation, and two tastes match, then Slow person does not delays, and speed person is the fastest.But Radix Kansui also can not be gently with also, Radix Kansui stops the disease that energy profit is the wettest, it is impossible to the false wet disease of profit. Water is from lower and invade upper person, and also, water is from upper and invade lower person, and wet vacation person is also for wet true person.The wettest available Radix Kansui is to open its water channel, false Wet unavailable Radix Kansui is with certainly its upstream.The wettest real for pathogenic water, false wet be the void of vigour, deficient syndrome and the method controlled by reality, do not violate void Guarding against of void, therefore one certainly revolves and dies also.

Radix Phytolaccae has another name called exhaled when land, night, for the root of Phytolaccaceae plant pokeweed, began to be loaded in Shennong's Herbal.Enter spleen, bladder Warp.Function cures mainly logical two just, removing water retention by purgation, eliminating stagnation.Harness the river swollen, distension, tinea pedis, sore throat, carbuncle, malignant boil." herbal classic ": main watery distension, hernia Abdominal mass, numbness；Press except carbuncle." not Lu ": treating pathogen in the heart, edema, flaccidity syndrome and arthralgia syndrome, abdominal distention flood is straight, dredges the five internal organs, aproll gas." property of medicine opinion ": energy Rush down ten kinds of diseases caused by retention of the body fluids；Sore throat is obstructed, and thinly-sliced vinegar is endured, outer thin being recovered in the swollen place of larynx.

Rhizoma Alismatis nature and flavor: sweet, cold.Gui Jing: enter kidney, bladder warp.Effect: diuretic, eliminating dampness by diuresis, expel the heat-evil.Controlling dysuria, edema is swollen Full, vomiting, dysentery, phlegm retention, tinea pedis, gonorrhea, hematuria." herbal classic ": main anemofrigid-damp arthralgia, breast is difficult, and disappear water, supports the five internal organs, physical strength profiting, fertilizer Strong." not Lu ": tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drip, cuts off the water by bladder, three Jiao." the property of medicine Opinion ": main essence of suffering from a deficiency of the kidney, from going out, controls five types of stranguria, profit bladder heat, straight through water passage.

Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomitting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, heart-fire is high Containing, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.Rhizoma Coptidis (processed with wine) is apt to The clear part of the body cavity above the diaphragm housing the heart and lungs is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tying mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomit acid regurgitation.

The Fructus Sophorae, for China's parts of generic medicinal plants, the dry flower and alabastrum of leguminous plant Chinese scholartree (Sophora japonica L.), Mature fruit.Flower is claimed Flos Sophorae by medical material commodity, and alabastrum claims the Flos Sophorae Immaturus, fruit to claim the Fructus Sophorae.Its cold in nature, bitter in the mouth, has cooling blood for hemostasis, liver heat removing Effect of improving eyesight, can treat bleeding hemorrhoids, discharging fresh blood stool, dysentery, metrorrhagia, stranguria with blood liver-heat conjunctival congestion, the disease such as have a dizzy spell.According to system Meter, the chiang ya wan with the Flos Sophorae Immaturus, the Fructus Sophorae as raw material production, JINGWANHONG, Pilulae Fructus Sophorae reach kind more than 30；The seventies, along with medical industry Development, produces rutin, beniol, troxerutin etc., to diseases such as treatment coronary heart disease, hypertension, cerebral vessels embolisms, evident in efficacy. Record for Pharmacopoeia of the People's Republic of China nineteen ninety version.Flower is claimed Flos Sophorae by medical material commodity, and alabastrum claims the Flos Sophorae Immaturus, fruit to claim the Fructus Sophorae.

Specific embodiment 1

By Herba Menthae 1000g, Myrrha 1000g, Rhizoma Et Radix Notopterygii 1000g, Radix Angelicae Dahuricae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, the Borneolum Syntheticum 1000g way of distillation It is vaporized into crystallization, pulverizes stand-by, for component 1；Other raw materials Fructus rhois chinensis 1000g, Radix Phytolaccae 1000g, Radix Kansui 1000g, Radix Salviae Miltiorrhizae 1000g, Semen Persicae 1000g, Radix Notoginseng 1000g, Rhizoma Phragmitis 1000g, Flos Carthami 1000g, Radix Sanguisorbae 1000g, Olibanum 1000g, Rhizoma Alismatis 1000g, Eupolyphaga Seu Steleophaga 1000g, Rhizoma Coptidis 1000g, Fructus Sophorae 1000g, be soaked in water, heated and boiled 3 times, each 1-2 hour, filters, and filtrate is standby With；By in the filtrate suction concentrating under reduced pressure tank merging latter 3 times, being evaporated to relative density is 1.20, temperature to 60 DEG C-70 DEG C Extractum；Become component 2, blending ingredients 1 and component 2, mediation substrate, become gel；Described substrate is selected from: propolis, poly-Pyrusussuriensis Ester-80, triethanolamine, propylene glycol, the one or many in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline Kind, furnishing eye cream ultraviolet disinfection is bottled.

Specific embodiment 2

By Herba Menthae 1200g, Myrrha 1200g, Rhizoma Et Radix Notopterygii 1200g, Radix Angelicae Dahuricae 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g, the Borneolum Syntheticum 1200g way of distillation It is vaporized into crystallization, pulverizes stand-by, for component 1；Other raw materials Fructus rhois chinensis 1200g, Radix Phytolaccae 1100g, Radix Kansui 1100g, Radix Salviae Miltiorrhizae 1200g, Semen Persicae 1100g, Radix Notoginseng 1100g, Rhizoma Phragmitis 1200g, Flos Carthami 1200g, Radix Sanguisorbae 1100g, Olibanum 1200g, Rhizoma Alismatis 1100g, Eupolyphaga Seu Steleophaga 1100g, Rhizoma Coptidis 1200g, Fructus Sophorae 1200g, add soak with ethanol 2-3 hour accounting for its quality 7-10 times, heating extraction 2 Secondary, each 1-2 hour, united extraction liquid, remove supernatant after standing, then 100-120 mesh filters, then through the molecular weight that dams is The ultrafiltration post ultrafiltration of 5000-10000, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C.Again by above-mentioned ethanol The medicinal residues of the crude drug extracted add 10 times amount water, heating and refluxing extraction 2 times, each 1～2 hour, merge quiet by 2 extracting solution Put, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, mix two kinds and extract filtrates and insert economic benefits and social benefits and be concentrated in vacuo In device, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；Cold preservation liquid is added The filter aid kieselguhr of 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, Become component 2.By component 1 and the merging of component 2, mediation substrate, become gel；Described substrate is selected from: propolis, Polysorbate- 80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline, Furnishing eye cream ultraviolet disinfection is bottled.

Specific embodiment 3

By Herba Menthae 1200g, Myrrha 1200g, Rhizoma Et Radix Notopterygii 1300g, Radix Angelicae Dahuricae 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g, the Borneolum Syntheticum 1200g way of distillation It is vaporized into crystallization, pulverizes stand-by, for component 1；Take other raw materials Fructus rhois chinensis 1200g, Radix Phytolaccae 1100g, Radix Kansui 1300g, Radix Salviae Miltiorrhizae 1200g, Semen Persicae 1100g, Radix Notoginseng 1300g, Rhizoma Phragmitis 1200g, Flos Carthami 1200g, Radix Sanguisorbae 1300g, Olibanum 1200g, Rhizoma Alismatis 1200g, Eupolyphaga Seu Steleophaga 1200g, Rhizoma Coptidis 1200g, Fructus Sophorae 1200g, soaked and be placed in lid stainless steel cask, added 70% ethanol, quality For coarse grained 0.8-1 times, stir, moistening airtight placement more than 1 hour, make fully to expand；By filter plate bottom percolator Drug sample after moistening expansion is mixed after paving with gauze bag parcel pine again do to dissipate, then contain powder, uniformly with rustless steel spoon Load percolator, fill 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, and loading in layer, suitably pressurize, medicine Powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the blowing below percolator Valve, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about About 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation speed general For 1000g medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into liquid container；Will Percolate merges standing, stand for standby use；The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, relative density when being concentrated into 90 DEG C It is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, filtrate Insert again in economic benefits and social benefits vacuum concentrator, be concentrated into every 1ml crude drug amount Han 0.1g, for component 2.By component 1 and the merging of component 2, Mediation substrate, becomes gel；Described substrate is selected from: propolis, Tween-80, triethanolamine, propylene glycol, semi-synthetic fatty acid One or more in glyceride, poloxamer, Polyethylene Glycol, lanoline, furnishing eye cream ultraviolet disinfection is bottled.

Pharmacological toxicity is tested

Acute toxicity testing data

1, experimental technique

Depilatory is uniformly coated with by guinea pig back spinal column both sides, makes unhairing scope about 40 square centimeters.Clean depilatory Returning cage to observe 24 hours, often group Cavia porcellus is coated with Chinese medicine eye mask 0.2,0.4 and 0.8ml of the present invention respectively, respectively containing crude drug 92mg, 184mg and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, is put to death by Cavia porcellus, the heart, liver, Kidney and depilation skin do pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, has no that local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, Liver, kidney and depilation skin compare also no significant difference with compareing word.

Result is pointed out, and Chinese medicine eye mask of the present invention, without local irritant effect, also has no that general toxicity shows.Show in the present invention Medicine eye mask uses safety.

Long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often group 15.In guinea pig back spinal column both sides, depilatory is uniformly coated with so that it is de- Hair scope about 40 square centimeters.Clean depilatory, often organize Cavia porcellus after observing 24 hours and be coated with eye mask 0.2,0.4 and of the present invention respectively 0.8ml, respectively containing crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observes Cavia porcellus Ordinary circumstance, experiment is put to death animal after terminating and is carried out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks go to hair-fields, have no that local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group and control animals chroma of hair, ingest, matched group no significant difference, blood biochemistry checking, the medication such as extremity are movable Group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious disease Become.Prompting, Chinese medicine eye mask long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Examination Test result to show: Chinese medicine eye mask experiment safety of the present invention.

Pharmacological experiment

One, the microcirculation experimental technique of the present invention:

1, materials and methods: take 50 mices, is randomly divided into 5 groups, often 10 (male and female half and half) of group, matched group every Mus auris dextra Painting normal saline is a little；Positive controls every Mus auris dextra gives new seven supercilious look frosts of commercially available herborist, and (Shanghai herborist cosmetics have Limit company produces), test component is external eye cream 400mg/kg/h of the present invention.15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, subsequently tail vein injection 0.1% epinephrine 0.1mL/10g, observe mouse right ear fine motion quiet immediately CUN KOU footpath (μm) and 0.2mm2 blood capillary net number .t inspection process experimental data.

2 results and discussion

2.1. on microcirculatory impact

Compared with matched group, tested group 1 has showed increased (P ＜ 0.01) to mice capillary open number；Tested group 2 right Venule bore and capillary open number dramatically increase (P ＜ 0.01)；Tested group 3 to mice fine motion, vein bore and hair Thin vessel open number all has increase (P ＜ 0.01)；Illustrate to be improved microcirculation by reagent, have function of promoting blood circulation to disperse blood clots (table 1).

Table 1, eye mask of the present invention are on mice fine motion, vein bore and the impact of capillary open number

Two, the impact on Oleum Tiglii induced mice auricle edema

Take healthy mice 30, be randomly divided into 3 groups, be i.e. blank group, new seven supercilious look frost positive controls, eye of the present invention Frost group, often organizes 10, male and female half and half, and positive controls and instant component are not smeared, and blank group smears isodose life Reason saline, successive administration 7 days, it is administered latter 0.5 hour in last, surveys outside the left in ear of mice and be coated with Oleum Tiglii proinflammatory agent (2% Fructus Crotonis Oil, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.1ml causes inflammation, and cause inflammation and lays with card punch (aperture 6mm) for latter 4 hours Left and right auricle, weighs, and using left and right auricle weight difference as swelling degree, the results are shown in Table 2.

The table 2 impact (X ± SD) on Oleum Tiglii induced mice auricle edema

Group	Number of animals (only)	Swelling (mg)
			Blank group	10	8.51 soil 1.72
New seven supercilious look frost groups	10	5.64±1.59**
			Eye cream group of the present invention	10	4.12±1.36#

Note: compare with matched group: * * P ＜ 0.01；Compare with positive controls: #P ＜ 0.05；Can by upper table experimental result To find out, eye cream of the present invention has pharmacological action of preferably subsiding a swelling.

Three. the impact of rat paw edema caused by Carrageenan

Take healthy rat 30, body weight 180-220g, be randomly divided into blank group, new seven supercilious look frost positive controls, Eye cream group of the present invention.Often group 10, male and female half and half, sub-cage rearing.Positive controls and drug component of the present invention are smeared other every day 0.2g, blank group gives the normal saline of same dosage and smears, successive administration 7 days, is administered latter 30 minutes in last, exists respectively Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ only causes inflammation, respectively at cause scorching before and cause inflammation after 15,30, 60, the girth surveying the Rat Right metapedes sole of the foot in 120,240 minutes, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching Front foot sole of the foot girth)/cause scorching front foot sole of the foot girth × 100%]；The results are shown in Table 3.

The impact (X soil SD) of rat paw edema caused by table 3 Carrageenan

Note: compare with matched group: * * P ＜ 0.01；Compare with positive controls: #P ＜ 0.05；Can by upper table experimental result To find out, medicine group of the present invention has the pharmacological action of blood stasis dispelling of preferably subsiding a swelling.

3 discuss

Theory of Chinese medical science think major part eye pouch generation relevant with Liver and kidney void, after Liver and kidney void, kidney essense can not nourishing the liver blood, and " liver opening at eye ", finally loses because of essence and blood, shows and be formed for lower eyelid edema on eyes, and eye pouch is the biggest.And the modern times grind Study carefully and also confirm that eye pouch is owing to often staying up late, emotional instability, eye strain, aging, cause vein blood vessel blood flow rate excessively Slowly, eye part skin red blood cell is for hypoxgia, and in vein blood vessel, carbon dioxide and metabolic waste accumulation too much, are formed chronic Anoxia, blood is dark and forms delay and causes eye eye pouch, the appearance of eye edema, and this is to match with theory of Chinese medical science 's.

Eye pouch should be suited the remedy to the case after being formed, and consults a physician, finds out the cause of disease, treats in time；Keep in high spirits, reduce essence God's burden, lives a regular life, and controls tobacco and wine, ensures sufficient sleep, promotes QI and blood vigorous, and appearance is shone；Strengthen pressing of eye Rub, improve local blood circulation state, reduce congestion and be detained；As being coated with oil-containing and dividing, eye cream that moisture is sufficient, make eye part skin and skin Undertissue is dynamic, desalinates eye pouch, ocular edema.

The present invention, with reference to the achievement of Chinese medicine pharmacological research at all times, screens inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving eyesight Nebula removing, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence are let out poison, promoting blood circulation to remove blood stasis, are regulated human body except the natural Chinese medicine of water, strengthening vital QI to eliminate pathogenic factors, purging FU-organs Metabolism function, improve human body periocualr skin blood circulation, thus reach subside a swelling blood stasis dispelling, fatigue alleviating, compact eye flesh Skin.Desalination eye pouch, beautifies the purpose of appearance.The present invention is according to Traditional Chinese medical theory and modern pharmacological research result, repeated screening Medicine for external use, is configured to Chinese medicine eye cream, has blood circulation promoting and blood stasis dispelling, improving acuity of vision and removing nebula, temperature promoting blood circulation, and skin-active is subsided a swelling, and blood-nourishing and freckle-removing, compact flesh Effect of skin.Can effectively expand peripheral vessel, improve face microcirculation near the eyes, blood stasis dispelling of subsiding a swelling, pigmentation is had certain pressing down Make and use.

Clinical trial

Illustrate: eye pouch, eye edema are treated in May ,-2015 in May, 2014, use self-control eye cream by my institute, and curative effect shows Writing, existing report is as follows.

Clinical data: clinic chooses eye pouch obvious person 80 example.The maleest 22 people, women 58 people.Age 28-58 year, averagely 35.2 years old；Unmarried 32 example, the married 48 example, do not educate person 21 example；The course of disease 6 months-12 years, average 5.33 years；Educational level is big Learn to read and write 56 people, white collar, teacher, cadre, office staff 55 example, other staff 30 example.Readme is often stayed up late 45 examples of playing games, and loses Passing 35 to fall, 20 examples of having a sleepless night, daily maintenance 67 people near the eyes, laser therapy eye pouch recurs 12 people.Clinic is divided into treatment group 40 example, right According to organizing 40 examples.

Therapeutic Method: treatment group uses homemade traditional Chinese drug eye cream, Fang Yong: Fructus rhois chinensis 12g, Radix Phytolaccae 11g, Radix Kansui 12g, Rhizoma Et Radix Notopterygii 13g, Myrrha 12g, Radix Salviae Miltiorrhizae 11g, Semen Persicae 11g, Radix Notoginseng 12g, Rhizoma Phragmitis 11g, Flos Carthami 12g, Radix Sanguisorbae 11g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Herba Menthae 13g, Borneolum Syntheticum 13g, Radix Angelicae Dahuricae 13g, Olibanum 12g, Rhizoma Alismatis 12g, Eupolyphaga Seu Steleophaga 12g, Rhizoma Coptidis 12g, Fructus Sophorae 12g, prepare as described in Example 3 Become eye cream.

Take eye cream matched group, often organize 50 examples, use commercially available L'Oreal's dermo-expertise revitalift eye respectively.

Operating process: when carrying out, personnel put down in bed, with cleansing milk cleaning face, facial with negative ion atomizer spraying, Coordinating meridian point massage 12 methods to carry out facial massage, emphasis massage is done in local near the eyes, takes eye after time about 10min. simultaneously Frost, is uniformly applied to eyelid surrounding, is careful not to do into eyes, can suitably massage 10-15 minute.Once a day, within 1 month, it is 1 treatment Journey.After the course for the treatment of terminates, monthly follow up a case by regular visits to 1 time, follow up a case by regular visits to continuously 3 months.Advise patient to take a good rest during treatment, and disable other eye Frost, eye cream.

Criterion of therapeutical effect

Fully recovering: after treating for 2 courses for the treatment of, eye pouch, eye edema substantially disappear, and curative effect maintains more than 1 month, eyestrain delays Solve；Effective: eye pouch is the most thin out, disappear more than 50%, the conscious satisfaction of patient, sleep quality is good；Or eye pouch disappears during treatment, But it is bad to follow up a case by regular visits to middle sleep, overtime work has again recurrence；Invalid: eye pouch, eye edema change inconspicuous or unchanged；Or once disappear More than 50%, but substantially increase the weight of in following up a case by regular visits to, testing crew is unsatisfied with.

Therapeutic outcome: treatment group total effective rate compares with each matched group, difference all has significance (P ＜ 0.01), illustrates certainly Eye cream curative effect processed is substantially better than commercially available eye cream.Refer to table 1

13 groups of Comparison of therapeutic tables of table

Note: compare * P ＜ 0.01 with other each group

Follow-up results follows up a case by regular visits to find, massage person is better than the personage not massaged.After recurrence, if being continuing with the most effective.

Illustrate: the present invention with reference to the achievement of Chinese medicine pharmacological research at all times, screening inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, Improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence let out poison, promoting blood circulation to remove blood stasis, regulation except the natural Chinese medicine of water, strengthening vital QI to eliminate pathogenic factors, purging FU-organs The metabolism function of human body, improve human body periocualr skin blood circulation, thus reach subside a swelling blood stasis dispelling, fatigue alleviating, compact eye Portion's skin.Desalination eye pouch, beautifies the purpose of appearance.The present invention is according to Traditional Chinese medical theory and modern pharmacological research result, repeatedly Screening medicine for external use, is configured to Chinese medicine eye cream, has blood circulation promoting and blood stasis dispelling, improving acuity of vision and removing nebula, temperature promoting blood circulation, and skin-active is subsided a swelling, blood-nourishing and freckle-removing, tightly Cause effect of skin.Can effectively expand peripheral vessel, improve face microcirculation near the eyes, blood stasis dispelling of subsiding a swelling, pigmentation is had necessarily Inhibitory action.

Claims

1. the Chinese medicine eye cream alleviating eye pouch, it is characterised in that described Chinese medicine eye cream includes the raw material of following parts by weight Medicine: Fructus rhois chinensis 10～20 parts, Radix Phytolaccae 10～20 parts, Radix Kansui 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Myrrha 10～20 parts, Radix Salviae Miltiorrhizae 10 ～20 parts, Semen Persicae 10～20 parts, Radix Notoginseng 10～20 parts, Rhizoma Phragmitis 10～20 parts, Flos Carthami 10～20 parts, Radix Sanguisorbae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, Rhizoma Alismatis 10～20 parts, soil Trionyx sinensis Wiegmann worm 10～20 parts, Rhizoma Coptidis 10～20 parts, the Fructus Sophorae 10～20 parts.

Alleviate the Chinese medicine eye cream of eye pouch the most according to claim 1, it is characterised in that described Chinese medicine eye cream includes following heavy Amount number crude drug: Fructus rhois chinensis 10～15 parts, Radix Phytolaccae 10～15 parts, Radix Kansui 10～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Myrrha 10～ 15 parts, Radix Salviae Miltiorrhizae 10～15 parts, Semen Persicae 10～15 parts, Radix Notoginseng 10～15 parts, Rhizoma Phragmitis 10～15 parts, Flos Carthami 10～15 parts, Radix Sanguisorbae 10 ～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, Rhizoma Alismatis 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Rhizoma Coptidis 10～20 parts, the Fructus Sophorae 10～20 parts.

The most slowly solve the Chinese medicine eye cream of eye pouch, it is characterised in that described Chinese medicine eye cream includes following The crude drug of parts by weight: Fructus rhois chinensis 10～20 parts, Radix Phytolaccae 10～20 parts, Radix Kansui 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Myrrha 10 ～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Semen Persicae 10～20 parts, Radix Notoginseng 10～20 parts, Rhizoma Phragmitis 10～20 parts, Flos Carthami 10～20 parts, Radix Sanguisorbae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Herba Menthae 10～15 parts, Borneolum Syntheticum 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Olibanum 10～15 parts, pool Rush down 10～15 parts, Eupolyphaga Seu Steleophaga 10～15 parts, Rhizoma Coptidis 10～15 parts, the Fructus Sophorae 10～15 parts.

4. the preparation method of the Chinese medicine eye cream alleviating eye pouch as according to any one of claims 1 to 3, it is characterised in that Described preparation method comprises the following steps:

Alleviate the preparation method of the Chinese medicine eye cream of eye pouch the most according to claim 4, it is characterised in that in described step a, first Crude drug Herba Menthae, Myrrha, Rhizoma Et Radix Notopterygii, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae are distilled with Borneolum Syntheticum steam method, obtains crystal, then pulverize, mistake 100-120 mesh sieve, standby as component 1.

Alleviate the preparation method of the Chinese medicine eye cream of eye pouch the most according to claim 4, it is characterised in that in described step b, will Remaining crude drug shreds, and is soaked and has been placed in lid stainless steel cask, adds 70% ethanol, and quality is coarse grained 0.8-1 times, Stir, moistening airtight placement more than 1 hour, make fully to expand；After bottom percolator, filter plate gauze bag parcel is paved Drug sample after moistening expansion is mixed pine again do to dissipate, then contain powder with rustless steel spoon, load percolator uniformly, fill 10-12 Cm thick, even by T-bar pressure, then press aforesaid operations, and loading in layer, suitably pressurize, medicated powder loads and must not exceed percolation 2/3 eminence of cylinder；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then delays Slow addition 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, lid On filter cylinder, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow per minute 2 ～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into liquid container；Percolate is merged and stands, stand standby With.

Alleviate the Chinese medicine eye cream preparation method of eye pouch the most according to claim 4, it is characterised in that in described step c, by upper Stating the extracting solution that step is extracted, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is The concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is again Insert in economic benefits and social benefits vacuum concentrator, be concentrated into every 1ml extractum Han 0.1g, become component 2.

Alleviate the Chinese medicine eye cream preparation method of eye pouch the most according to claim 4, it is characterised in that in described step d, by group Divide in 1 input component 2, stir, heating, mediation substrate, become cream.

Alleviate the Chinese medicine eye cream preparation method of eye pouch the most according to claim 4, it is characterised in that in described step d, described Substrate is selected from: propolis, Tween-80, triethanolamine, propylene glycol, semi-synthetic fatty acid glyceride, poloxamer, poly-second two One or more in alcohol, lanoline.

10. according to any one of claim 1～9, alleviate the Chinese medicine eye cream of eye pouch, it is characterised in that using method is, Every time the most just before going to bed after face cleaning, by eye cream uniform application near the eyes, and massaging near the eyes 15-20 minute by middle finger finger belly, filling to it Dividing after absorbing, getting up early in second day washes away.