CN105267477A - Danshen leaf health tea capable of removing liver-fire for improving eyesight and preparation method of Danshen leaf health tea - Google Patents
Danshen leaf health tea capable of removing liver-fire for improving eyesight and preparation method of Danshen leaf health tea Download PDFInfo
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Abstract
The invention discloses Danshen leaf health tea capable of removing liver-fire for improving eyesight. The Danshen leaf health tea comprises, by weight, 10-50 parts of Danshen leaf, 10-20 parts of stir-fried feather cockscomb seed, 10-20 parts of fructus lycii, 10-20 parts of cape jasmine fruit, 10-20 parts of common selfheal fruit-spike, 10-20 parts of glossy privet fruit, 10-20 parts of white peony root, 10-20 parts of mulberry leaf, 10-20 parts of flos eriocauli, 10-20 parts of Hangzhou white chrysanthemum, 10-20 parts of tree peony bark, 10-20 parts of prepared fleece flower root, 10-20 parts of yerbadetajo herb and 10-20 parts of radix astragali. The Danshen leaf health tea capable of removing liver-fire for improving eyesight has the advantages that aiming at the behaviors of harming the livers due to the fact that urban office workers generally working with computers need to stare at computer screens for a long time, smoke and drink excessively and undergo intemperate night life, the Danshen leaf health tea adopting the traditional Chinese medicine compatibility is capable of tonifying deficiency, benefiting essential qi, dispelling pathogenic wind for improving eyesight and nourishing the liver and kidney, so that nutrient substances of the Danshen leaf are retained greatly and can be protected from being lost during processing.
Description
Technical field
The present invention relates to the health product containing the liver heat removing and eyesight improving deriving from plant composition, particularly a kind of Radix Salviae Miltiorrhizae leaf health-care tea and preparation method thereof of liver heat removing and eyesight improving.
Background technology
Present city working clan generally uses computer office, usually feels that eyes are astringent, fuzzy.The dry and astringent just asthenopic one of eyes in fact, if you are often facing to computer or books, excessive eye can consume liver blood.A wound is had in " five kinds of impairments caused by overstrain " of Huangdi's Internal Classics: " impairment of blood by looking for a long time ".Here blood, what refer to is exactly liver blood.
Modern metropolitan cities working clan generally uses computer office, and tobacco and wine are immoderate, and night life is uncontrolled, stays up late, and these have all directly injured irritability.The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and order.As deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia; Wind-heat of liver channel, visible conjunctival congestion is itched bitterly; Flaming up of liver-fire, visible keratoconjunctivitis; Excessive rising of liver-YANG, the then vertigo; Liver-wind stirring up internally, looks on visible order is oblique.
In fact, eyes and liver contact closely.Blood stored in the liver, namely liver has stored blood and regulates the function of blood volume, and liver opening at eye.The provisions that eyes are subject to blood just can look thing, and excessively uses eye, can make liver-blood deficiency, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see thing is fuzzy, nyctalopia etc.In addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can must cause damage to liver.In this case, occur that eyes are tired, visual deterioration, even shallow complexion, dizzy symptom, just not strange yet.Watching for a long time and radiation, the eye health for computer gang has buried hidden danger.This kind of people needs hepatoprotective while attention eye hygiene to nourish blood.In diet, the animal liverss such as a little Hepar Sus domestica, Hepar Gallus domesticus are suitably eaten in suggestion, supplement the food that beef, Carassius auratus, Herba Spinaciae, Herba Capsellae etc. are rich in vitamin simultaneously; In Chinese medicine, Radix Angelicae Sinensis, the Radix Paeoniae Alba etc. can be enriched blood, and Flos Chrysanthemi, Fructus Lycii then have effect of improving eyesight, and the people through conventional eye can by its tea-drinking in soaked generation.
Radix Salviae Miltiorrhizae (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current Radix Salviae Miltiorrhizae underground part and preparation thereof are widely used in clinical, but a large amount of aerial partss is given it up.There are some researches show, Radix Salviae Miltiorrhizae overground part contains the water soluble ingredient similar to root, and aerial parts is about the heavy twice of root, therefore, very necessary to the exploitation of Radix Salviae Miltiorrhizae overground part, and salvia root leaf tea is exactly a kind of mode of exploitation Radix Salviae Miltiorrhizae leaf.The present invention carries out dynamic analysis to the effective ingredient in Radix Salviae Miltiorrhizae leaf, and the Radix Salviae Miltiorrhizae leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of the salvia root leaf tea course of processing, to develop the high-quality salvia root leaf tea containing higher effective ingredient.Carry out preliminary analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.Result of study is as follows: (1) Radix Salviae Miltiorrhizae leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenols, flavonoid, vitamin C, salvianolic acid B and rosmarinic acid are in content peak period in JIUYUE substantially to mid-October.Consider that Radix Salviae Miltiorrhizae seals ridge in JIUYUE, picking leaves does not only affect Radix Salviae Miltiorrhizae root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, Radix Salviae Miltiorrhizae leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of Radix Salviae Miltiorrhizae leaf is that JIUYUE is to mid-October.(2) wither flavonoid, total phenols and the free aminoacid content adding Radix Salviae Miltiorrhizae leaf, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of Radix Salviae Miltiorrhizae leaf is about 6h.(3) by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of Radix Salviae Miltiorrhizae does not cut that to carry out steam beating effect best.(4) knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.(5) by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.(6) test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.(7) water extract of salvia root leaf tea, Radix Salviae Miltiorrhizae leaf and red sage root tea and ethanol extraction in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than Radix Salviae Miltiorrhizae leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.
Various nourishing the liver liver-protection health-care product, medicine spread unchecked on the market now, but great majority are had a good apperance only, false propaganda on a grand scale, probably without any health care, but cause the huge injury of the person, therefore, the health product of the effective hepatoprotective of search of health have very real significance.Chinese medicine hepatoprotective has advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.Modern metropolitan cities working clan generally uses computer office watching for a long time, tobacco and wine are immoderate, the behavior of the injury livers such as night life is uncontrolled, stay up late, the provisions that eyes are subject to blood just can look thing, and excessively use eye, can liver-blood deficiency be made, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see thing is fuzzy, nyctalopia etc.In addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can must cause damage to liver.If probably be difficult to adhere to by Drug therapy simple, carelessly use collyrium more can make eyes damaged, cause various oculopathy or blind danger, and it is cumbersome to take Chinese medicine, mouthfeel is not good, unsuitable long-term taking, and effect is also not necessarily desirable.
Summary of the invention
Technical problem to be solved by this invention is, city working clan generally uses computer office watching for a long time, tobacco and wine are immoderate, the behavior of the injury livers such as night life is uncontrolled, stay up late, the provisions that eyes are subject to blood just can look thing, and excessively uses eye, can make liver-blood deficiency, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see thing is fuzzy, nyctalopia etc.In addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can must cause damage to liver.If probably be difficult to adhere to by Drug therapy simple, carelessly use collyrium more can make eyes damaged, cause various oculopathy or blind danger, and it is cumbersome to take Chinese medicine, mouthfeel is not good, unsuitable long-term taking, and effect is also not necessarily desirable.Chinese medicine hepatoprotective has advantage that is nontoxic, that can be absorbed completely by organism, it is the Main way that we study, the most mouthfeel of these medical materials that the present invention chooses is light, and drug effect is remarkable, can long-term taking, also do not affect salvia root leaf tea taste, make people be easy to accept, more can reach tonify deficiency benefit vital essence preferably, dispelling pathogenic wind for improving eyesight, effect of enriching yin and nourishing kidney, specific aim is stronger.
For solving the problems of the technologies described above, the invention provides a kind of Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving, health tea described in it comprises the raw material of following parts by weight: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, fry Semen Celosiae 10 ~ 20 parts, Fructus Lycii 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, 10 ~ 20 parts, Folium Mori, Flos Eriocauli 10 ~ 20 parts, Flos Chrysanthemi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.
The Radix Salviae Miltiorrhizae leaf health-care tea of described liver heat removing and eyesight improving, in health tea described in it, the parts by weight of various raw material can be: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, fry Semen Celosiae 10 ~ 15 parts, Fructus Lycii 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Spica Prunellae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, 10 ~ 20 parts, Folium Mori, Flos Eriocauli 10 ~ 20 parts, Flos Chrysanthemi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.
The Radix Salviae Miltiorrhizae leaf health-care tea of described liver heat removing and eyesight improving, in health tea described in it, the parts by weight of various raw material can also be: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, fry Semen Celosiae 10 ~ 20 parts, Fructus Lycii 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, 10 ~ 15 parts, Folium Mori, Flos Eriocauli 10 ~ 15 parts, Flos Chrysanthemi 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Herba Ecliptae 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving, it is characterized in that, the preparation process of described Radix Salviae Miltiorrhizae leaf health-care tea comprises following aspect:
A.9-10 Radix Salviae Miltiorrhizae leaf is plucked the middle of the month, parch;
B. the Radix Salviae Miltiorrhizae leaf fried is kneaded, Titian;
C. other raw material pulverizing described, immersion ethanol are added extraction heat;
D. again by surplus stock extract medical filtration, be condensed into granule, powder or unguentum;
E. concentrated granule, powder or unguentum are mixed with the Radix Salviae Miltiorrhizae leaf prepared, sterilizing is prepared into health care medicinal tea.
In described step a, can at the fresh and tender Radix Salviae Miltiorrhizae leaf of 9-10 picked by hand in the middle of the month, dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.
In described step b, the Radix Salviae Miltiorrhizae leaf fried can be kneaded, then put into fragrance extracting machine Titian 20-30 minute, naturally dry after taking out.
In described step c, other raw materials can be got and clean and dry, in 70 DEG C of baking ovens, dry 8-12h, take out and be placed in cooling in drying baker, pulverized 80-100 mesh sieve with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.
In described steps d, paste extract can be placed in 70-90% ethanol and soak 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state filtrate, then insert in economic benefits and social benefits vacuum concentrator, the unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.
In described step e, the Radix Salviae Miltiorrhizae leaf made can be mixed with other raw materials of refinement, pack after ultraviolet ray sterilization bactericidal.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving, the preparation process of all the other raw materials can also be: get other raw materials and clean roguing, steep in the ethanol of 5-10 times amount, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill; Filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.
The present invention is directed to city working clan and generally use computer office watching for a long time, tobacco and wine are immoderate, night life is uncontrolled, the behavior of liver of staying up late, excessively must injure less than alleviation etc. with eye, can cause damage to liver like this, tonify deficiency benefit vital essence of the present invention, dispelling pathogenic wind for improving eyesight, effect of nourishing the liver and kidney, and it is not good to solve Chinese medicine mouthfeel, frangible shortcoming, remains the nutrient substance of Radix Salviae Miltiorrhizae leaf greatly, makes it not have work in-process to run off, on the make avoiding secondary pollution, is the health preserving tea of green health environmental protection completely.Be conducive to blue or green taste after green removing in high temperature, improve fragrance, improve mouthfeel; The present invention considers the making advanced technologies of Tea Processing being integrated in salvia root leaf tea, in conjunction with tea aroma raising technique.The most mouthfeel of these medical materials that the present invention chooses is light, and drug effect is remarkable, can long-term taking, also do not affect salvia root leaf tea taste, make people be easy to accept, more can reach preferably, the eyes caused flaming up of liver-fire, excess eye-using are especially dry astringent, and fuzzy viewing symptom specific aim is stronger.
Detailed description of the invention
The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and order.As deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia; Wind-heat of liver channel, visible conjunctival congestion is itched bitterly; Flaming up of liver-fire, visible keratoconjunctivitis; Excessive rising of liver-YANG, the then vertigo; Liver-wind stirring up internally, looks on visible order is oblique.
Eyes and liver contact closely.Blood stored in the liver, namely liver has stored blood and regulates the function of blood volume, and liver opening at eye.The provisions that eyes are subject to blood just can look thing, and excessively uses eye, can make liver-blood deficiency, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see thing is fuzzy, nyctalopia etc.In addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can must cause damage to liver.In this case, occur that eyes are tired, visual deterioration, even shallow complexion, dizzy symptom, just not strange yet.Watching for a long time and radiation, the eye health for computer gang has buried hidden danger.
Radix Salviae Miltiorrhizae (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current Radix Salviae Miltiorrhizae underground part and preparation thereof are widely used in clinical, but a large amount of aerial partss is given it up.There are some researches show, Radix Salviae Miltiorrhizae overground part contains the water soluble ingredient similar to root, and aerial parts is about the heavy twice of root, therefore, very necessary to the exploitation of Radix Salviae Miltiorrhizae overground part, and salvia root leaf tea is exactly a kind of mode of exploitation Radix Salviae Miltiorrhizae leaf.The present invention carries out dynamic analysis to the effective ingredient in Radix Salviae Miltiorrhizae leaf, and the Radix Salviae Miltiorrhizae leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of the salvia root leaf tea course of processing, to develop the high-quality salvia root leaf tea containing higher effective ingredient.Carry out preliminary analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.Result of study is as follows: (1) Radix Salviae Miltiorrhizae leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenols, flavonoid, vitamin C, salvianolic acid B and rosmarinic acid are in content peak period in JIUYUE substantially to mid-October.Consider that Radix Salviae Miltiorrhizae seals ridge in JIUYUE, picking leaves does not only affect Radix Salviae Miltiorrhizae root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, Radix Salviae Miltiorrhizae leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of Radix Salviae Miltiorrhizae leaf is that JIUYUE is to mid-October.(2) wither flavonoid, total phenols and the free aminoacid content adding Radix Salviae Miltiorrhizae leaf, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of Radix Salviae Miltiorrhizae leaf is about 6h.(3) by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of Radix Salviae Miltiorrhizae does not cut that to carry out steam beating effect best.(4) knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.(5) by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.(6) test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.(7) water extract of salvia root leaf tea, Radix Salviae Miltiorrhizae leaf and red sage root tea and ethanol extraction in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than Radix Salviae Miltiorrhizae leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.
The mature seed that Semen Celosiae (Semencelosiae) is amaranthaceous plant annual herb Herba Celosiae argenteae.All there is wild or cultivation in most of China area.Semen Celosiae is one of conventional a herb of the traditional Chinese medical science, has effect of heat of dispeling the wind, clearing away liver-fire, nebula removing." herbal classic is met former ": " Semen Celosiae, controls wind heat order disease, same with Semen Cassiae merit.It controls wind scabies itching over the body, heat in skin, with the wind heat of the JUE YIN meridian invasion of vessels that can fall apart also." modern clinic also can be used for disease such as treatment hypertension etc.But deficiency of the liver order disease is unsuitable alone, platycoria, glaucoma patient prohibit clothes.
Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia." Japan hanako materia medica ": " control wind and mend consumptive disease, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, relieving restlessness of bringing down a fever, QI invigorating, controls the capable hot disease in sky, pestilence miasma mania and irritation, and married woman's blood is transported, and hemorrhoidal hamorrhage rushes down blood, hemorrhoid complicated by anal fistula carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion, bulbar conjunctiva polyp." Radix Paeoniae Alba extract raises hepatic injury caused by D-galactosamine and SGPT obvious antagonism, SGPT can be made to reduce, and make hepatocellular pathological changes and downright bad recover normal. the gross activity of the lactic acid dehydrogenase that the acute liver injury of rats that the ethanol extraction of the Radix Paeoniae Alba can make aflatoxin B1 cause shows and isozyme raises and is minimized. and white peony root's total glycoside can suppress carbon tetrachloride induced mice Plasma glutamate-pyruvate transaminase and lactic acid dehydrogenase to raise, and acid denaturation is bitten to liver organization, necrosis has certain antagonism. and someone thinks, hepatic injury caused by carbon tetrachloride destroys because of membrane structure generation peroxidation, glutamate pyruvate transaminase and lactic acid dehydrogenase in blood are raised, white peony root's total glycoside may have protective effect to hepatocyte injury, therefore transaminase can be made to reduce.
Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation.
Flos Eriocauli: latin name medical material FlosEriocauli; Former plant Eriocaulonbuergeria-numKoern.For cataract, the many tear of photophobia, nyctalopia.Flos Eriocauli light weight is pungent loose, and being longer than and evacuating wind-heat of liver channel and improving acuity of vision and removing nebula, is the product that ophthalmology is conventional.Cataract caused by all wind heat, photophobia is shed tears, and often joins Herba Equiseti Hiemalis, Flos Buddlejae, Fructus Atriplicis Sibiricae with dispelling wind and heat pathogens; If wind heat more very, liver-fire is partially prosperous, and conjunctival congestion and swelling pain is more acute, and join Radix Gentianae, Flos Chrysanthemi, Semen Cassiae etc., with dispelling wind and removing heat, liver heat removing and eyesight improving, as " Precious Book of Ophthalmology " Flos Eriocauli soup; If corneal nebula after pox, then join Periostracum Cicadae, testa mungo with dispelling pathogenic wind for improving eyesight, heat-clearing and toxic substances removing, as " Standards of Diagnosis and Treatment " Flos Eriocauli falls apart.As for treatment nyctalopia, Gu Qingcao can with Hepar Sus domestica, or join Rhizoma Atractylodis, the same use of Faeces Vespertilionis again, with liver-benefiting eye-brightening." proper book on Chinese herbal medicine ": " obtain wether liver, control night blindness in children." " must book on Chinese herbal medicine be joined ": " join Pheretima, Olibanum smokes nose, control headache; Join corneal nebula after Pulvis concha Mactrae, Hepar Sus domestica treatment of smallpox.”
The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”
Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in the diseases such as treatment icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three burnt pathogenic heats, can treating the liver gallbladder burning hot on the conjunctival congestion and swelling pain of attacking, often join Radix Et Rhizoma Rhei use, as Fructus Gardeniae soup " Shengji Zonglu ".
Spica Prunellae (Classification system: Prunellavulgaris), also known as ferrum color grass.Bitter, acrid, cold.Enter liver, gallbladder meridian.To relieve inflammation or internal heat improving eyesight: control conjunctival congestion and swelling pain, headache.Clearing away liver-fire, blood pressure lowering: control hypertension, hyperlipidemia, high blood viscosity and hyperglycemia.Mass dissipating and swelling eliminating: control scrofula, goiter, acute mastitis swell and ache.Function cures mainly liver heat removing, eliminating stagnation, diuresis; Control the diseases such as pestilence, acute mastitis, ophthalmalgia, jaundice, gonorrhea, hypertension; Leaf can for tea.Control lymphoid tuberculosis, thyromegaly, scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia are shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.
Fructus Lycii is traditional rare Chinese medicine, is again a kind of tonic food, and being most suitable for arranges in pairs or groups with Ganoderma takes.In the list of 63 kinds of medicine-food two-purposes of Ministry of Public Health announcement, rank first.As Chinese medicine, the flat sweet in the mouth of Fructus Lycii property, has effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, lung moistening, arranges in pairs or groups can prevent all kinds of diseases and ailments with Ganoderma.Pass through chemical composition analysis, the fruit of Fructus Lycii detects containing nutritional labelings such as abundant carotene, vitamin C, Fructus Lycii proteoglycan, betanin, linoleic acid and ferrum, phosphorus, calcium, has tonify deficiency to calm the nerves, improving eyesight is dispeled the wind, the effect such as nourishing kidney lung moistening and hepatoprotective antitumor.Fructus Lycii contains the required nutrient substance of abundant carotene, multivitamin and the healthy eye such as calcium, ferrum, therefore has the merit of improving eyesight, is commonly called as " bright eye ".What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing duskization and nyctalopia, usually uses Fructus Lycii.Further, Fructus Lycii is from the Book of Songs " combines in luxuriant Qi ", and just for medicine, the history in existing more than 3000 years so far, just has the alone Fructus Lycii of Jin Chaoge flood to smash juice from ancient times and drip order, the story for the treatment of ophthalmology illness.The name of Fructus Lycii, first appeared in Shennong's Herbal, is listed as top grade, very popular over the past thousands of years.
Folium Mori are dried leaves of moraceae plants Mulberry.Gather after first frost, removing impurity, drying and obtain, is a kind of wind-heat-dispersing medicinal, both oral administration, also can external application.It is cold in nature, sweet in the mouth, hardship, has effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, can treat anemopyretic cold, lung-heat type cough, dizziness headache, the disease that conjunctival congestion is dim-sighted.In modern times, doctor trained in Western medicine uses Folium Mori and Folium Mori biological preparation as the medicine improving diabetes and other various difficult miscellaneous diseases, thinks that its drug effect is very extensive.There are clearing away lung-heat and moistening for dryness, cough-relieving, reduce phlegm and internal heat, reduce phlegm, control night sweat; Tonifying liver, liver heat removing and eyesight improving, treatment dizziness and blurred vision, insomnia, elimination eye strain; Detumescence, purify the blood ' treatment dysentery, stomachache, fat-reducing, except beriberi, sharp large and small intestinal; Anti-stress, removing heat from blood, blood pressure lowering, blood fat reducing, prevention myocardial infarction, cerebral hemorrhage, dispel headache, long hair; Blood sugar lowering, anti-sugar are sick.
Flos Chrysanthemi is name little Tang Huang, chryanthemum parthenium also, is the special product in area, Tongxiang.Flos Chrysanthemi, the Flos Chrysanthemi in it and Anhui, the Flos Chrysanthemi in Henan is all that the tea that China is famous uses chrysanthemum.Flos Chrysanthemi in state-owned long cultivation history." Hang Bai Flos Chrysanthemi " one is to carrying with " Dragon Well tea well-known tea ".Ancient times once made tribute.Hang Bai Flos Chrysanthemi lobe is as white as polished jade, and pistil is yellow as proof gold.Very high medical value, effect of life lengthening, " mending agriculture book " carries: " the sweet temperature of Flos Chrysanthemi property, clothes are the most useful for a long time." Yuan Dynasty's " Amplification on Materia Medica addendum " says: " nourishing YIN of Flos Chrysanthemi energy ".Li Shizhen (1518-1593 A.D.) Compendium of Material Medica road: the sharp five pulse conditions of ZANG-organs of chrysanthemum energy, adjusts extremity, controls wind syndrome of head and vulcanize; Also record one section of mythology: " angle passes on a message, Kang Fengzi, all the becoming an immortal to take chrysanthemum of Zhu child ".Effect of visible Flos Chrysanthemi.Practice city's Flos Chrysanthemi, also can for tea-drinking use, its color, smell and taste are not second to dragon well green tea.Often drink, can capillary resistance be strengthened, suppress the general character of blood capillary, play the effect that antiinflammatory is kept fit.
Cortex Moutan, has another name called Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Autumn excavates root, and removing radicula, strips root bark, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has suppression Platelet; Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.
The acid of Herba Ecliptae sweet in the mouth, cool in nature, enter Liver and kidney two warp, nontoxic.Nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, the diseases such as enterorrhagia.Smash juice painting eyebrow to send out, can promote hair growth, for oral administration have black hair, hair color effect.Tang Materia Medica is said, Herba Ecliptae " main dysentery, acupuncture skin ulcer is sent out, big vast blood can not the person of stopping respect it ".Also say in " Japan hanako materia medica ", Herba Ecliptae can " logical small intestinal, applies all skin ulcers and silkworm Guo for evacuation of pus, hemostasis ".Compendium of Material Medica is pointed out, Herba Ecliptae " black beard and hair, kidney tonifying is cloudy "." book on Chinese herbal medicine is stated " is thought, Herba Ecliptae " is treated hematuria and suffers from a deficiency of the kidney and become stranguria caused by overstrain ".Clinically, Herba Ecliptae is normal with the same use of Fructus Ligustri Lucidi, and Herba Ecliptae and Fructus Ligustri Lucidi have protecting the liver, the effect of transaminase of detoxifying, reduce, and can treat the hepatic and renal YIN deficiency, have a sleepless night vexed, tinnitus dizziness, the diseases such as soreness of the waist and knees.Stomach is weak, loose stool, insufficiency of kidney-YANG person should not take Herba Ecliptae.
Specific embodiment 1:
Specific embodiment 1:
9-10 plucks Radix Salviae Miltiorrhizae leaf the middle of the month, carries out parch, kneads, Titian.
Again all the other raw materials are fried Semen Celosiae, Fructus Lycii, Fructus Gardeniae, Spica Prunellae, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Folium Mori, Flos Eriocauli, Flos Chrysanthemi, Cortex Moutan, Radix Polygoni Multiflori Preparata, Herba Ecliptae, the Radix Astragali, pulverize, extraction, extract and make unguentum, granule or powder.
Two kinds of extract mixing, ultraviolet radiation for sterilizing and disinfecting packs.
Specific embodiment 2:
9-10 picked by hand in the middle of the month fresh and tender Radix Salviae Miltiorrhizae leaf 5000g, dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.Put into fragrance extracting machine Titian 30-45 minute after being kneaded by the Radix Salviae Miltiorrhizae leaf fried, naturally dry after taking out.
Get other raw materials again and fry Semen Celosiae 1500g, Fructus Lycii 1500g, Fructus Gardeniae 1500g, Spica Prunellae 1500g, Fructus Ligustri Lucidi 1500g, Radix Paeoniae Alba 1500g, Folium Mori 1500g, Flos Eriocauli 1500g, Flos Chrysanthemi 1500g, Cortex Moutan 1500g, Radix Polygoni Multiflori Preparata 1500g, Herba Ecliptae 1500g, Radix Astragali 1500g, cleans and dries, in 70 DEG C of baking ovens, dry 8-12h, take out and be placed in cooling in drying baker, pulverized 80-100 mesh sieve with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.Paste extract is placed in 70-90% ethanol and soaks 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution, is condensed into pasty state filtrate, insert in economic benefits and social benefits vacuum concentrator again, the unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.Then add Mel to be in harmonious proportion, make granule, the Radix Salviae Miltiorrhizae leaf of mixing Titian, ultraviolet disinfection, packs and get final product.
Specific embodiment 3:
9-10 picked by hand in the middle of the month fresh and tender Radix Salviae Miltiorrhizae leaf 3000g, dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.The Radix Salviae Miltiorrhizae leaf fried is kneaded, puts into fragrance extracting machine Titian 30-45 minute, naturally dry after taking out.
Get other raw materials again and fry Semen Celosiae 1200g, Fructus Lycii 1100g, Fructus Gardeniae 1100g, Spica Prunellae 1200g, Fructus Ligustri Lucidi 1100g, Radix Paeoniae Alba 1200g, Folium Mori 1100g, Flos Eriocauli 1200g, Flos Chrysanthemi 1100g, Cortex Moutan 1100g, Radix Polygoni Multiflori Preparata 1200g, Herba Ecliptae 1100g, Radix Astragali 1100g, gets other raw materials and cleans roguing, steeps in the ethanol of 5-10 times amount, be equipped with by medicated powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill; Filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.The Radix Salviae Miltiorrhizae leaf of mixing Titian, ultraviolet disinfection, packs and get final product.
Toxicology test
Long term toxicity test data
1, experimental technique
Random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean depilatory, observe and often organize Cavia porcellus after 24 hours and be coated with tea-drinking 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, with of the present invention group with matched group all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine tea-drinking life-time service of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine tea-drinking experiment safety of the present invention.
Cumulative toxicity is tested:
Chinese medicine tea-drinking of the present invention presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine tea-drinking of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine tea-drinking of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Skin and the test of body internal stimulus:
1. getting rabbit and shave hair, is example with tea-drinking of the present invention, carries out inducing and exciting contact test, viewing test rabbit after 24 hours and 48 hours, and all loseing skin has the phenomenon such as erythema and edema, with negative control group zero difference.Result shows, this patch is bordering on zero, namely without skin allergic reaction to dermoreaction intensity.
2. coloclysis cumulative toxicity test report in medicine body
Test method: select 20 healthy mices, female, each 10 of hero, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per anum coloclysis.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.
Pharmacological evaluation:
1 experiment material
1.1 medicine
Experimental drug: liver heat removing and eyesight improving tea of the present invention, prepares by detailed description of the invention 2.Positive control drug: Qing Gan Capsule, Changchun Overseas Pharmaceutical Group Co, authentication code: the accurate word Z20050091 of traditional Chinese medicines.
1.2 animal Wistar rats, Kunming mouse, ♀ ♂ all uses.
2 impacts on ALT, ET, NO content in hepatic injury mice serum
2.1 groupings: get 105 kunming mices and be divided into 6 groups at random, often organize 15, A group is Normal group; B group is model control group; C group is positive controls; D1 group to keep healthy medicinal tea (embodiment 2 obtained) low dose group for the present invention, and D2 group is dosage group in health tea of the present invention, and D3 group is health tea high dose group of the present invention;
2.2 modeling methods: the method establishment immunological liver injury in mice model adopting bacillus calmette-guerin vaccine and lipopolysaccharide associating.After each treated animal adaptability feeds 3d, except Normal group, every mice 1 tail vein injection bacillus calmette-guerin vaccine 5 × 107 viable bacterias, 12d intravenous injection lipopolysaccharide 7.5 μ g/ Mus after injection of BCG, put to death after 16h and draw materials, Normal group injects normal saline 2 times all in the same way.
2.3 administrations and process: the first day of intravenous injection bacillus calmette-guerin vaccine plays beginning gastric infusion, 1 time/d.Normal group and model control group: normal saline gavage, gavage amount is with the medication capacity of medication therapy groups; Positive control medicine treatment group: Qing Gan Capsule, 5.9g/kg dosed administration; The low 3.9g/kg of health tea treatment group of the present invention, middle 7.8g/kg, high 11.7g/kg dosed administration.Normal group is 16h after 12d injecting normal saline, and eyeball rear vein beard gets blood, and puts to death animal and get hepatic tissue censorship; All the other groups are 16h after intravenous injection lipopolysaccharide, and eyeball rear vein beard gets blood, and puts to death animal and get hepatic tissue censorship.
2.4 observation index and detection method: 1. detect glutamate pyruvate transaminase (ALT): adopt chemical colorimetry to measure.2. endogenous nitric oxide (N0) measures: adopt radioimmunology, take 0.5g liver and make 10% liver tissue homogenate, under 4 DEG C of conditions, 3000 turns/min, centrifugal 10min, gets supernatant.3. Endothelin (ET) detects: adopt radiation to exempt from method and directly measure blood plasma ET concentration.
Serum ALT respectively organized by table 1, the situation of change of ET, N0 compares
* compare with model group, * P < 0.05, * * P < 0.01; Δ compares with positive controls, Δ P < 0.05.
As can be seen from the above results, detecting qualified health tea of the present invention has significance to improve to ALT, ET, N0 content in hepatic injury mice serum, and has obvious protective effect to chronic hepatic injury, and comparing with positive control medicine has significant difference.
Radix Salviae Miltiorrhizae (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current Radix Salviae Miltiorrhizae underground part and preparation thereof are widely used in clinical, but a large amount of aerial partss is given it up.There are some researches show, Radix Salviae Miltiorrhizae overground part contains the water soluble ingredient similar to root, and aerial parts is about the heavy twice of root, therefore, very necessary to the exploitation of Radix Salviae Miltiorrhizae overground part, and salvia root leaf tea is exactly a kind of mode of exploitation Radix Salviae Miltiorrhizae leaf.The present invention carries out dynamic analysis to the effective ingredient in Radix Salviae Miltiorrhizae leaf, and the Radix Salviae Miltiorrhizae leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of the salvia root leaf tea course of processing, to develop the high-quality salvia root leaf tea containing higher effective ingredient.Carry out preliminary analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.Result of study is as follows: (1) Radix Salviae Miltiorrhizae leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenols, flavonoid, vitamin C, salvianolic acid B and rosmarinic acid are in content peak period in JIUYUE substantially to mid-October.Consider that Radix Salviae Miltiorrhizae seals ridge in JIUYUE, picking leaves does not only affect Radix Salviae Miltiorrhizae root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, Radix Salviae Miltiorrhizae leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of Radix Salviae Miltiorrhizae leaf is that JIUYUE is to mid-October.(2) wither flavonoid, total phenols and the free aminoacid content adding Radix Salviae Miltiorrhizae leaf, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of Radix Salviae Miltiorrhizae leaf is about 6h.(3) by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of Radix Salviae Miltiorrhizae does not cut that to carry out steam beating effect best.(4) knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.(5) by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.(6) test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.(7) water extract of salvia root leaf tea, Radix Salviae Miltiorrhizae leaf and red sage root tea and ethanol extraction in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than Radix Salviae Miltiorrhizae leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.
Model case:
The Qin, female, 30 years old, office's white collar.Frequent overtime work is stayed up late, and work every day is exactly facing to computer.Patient's readme excess eye-using, watching for a long time is fuzzy, and stays up late, and eyes are frequent dry astringent, and appearance skin is obscure, has mottle, and food is received not good, conscious tired, and right flank hypodynia, tired postemphasis, complexion is without pool, and the micro-Huang of sclera, lethargy is depressed, fatiguability.Sometimes menoxenia, premenstrual pain.Feel the pulse: thin white fur of tongue, deep-slow pulse.Be diagnosed as health without any inflammation through examination in hospital, be just in sub-health state.Use Chinese medicine tea-drinking of the present invention, Fang Yong: Radix Salviae Miltiorrhizae leaf 25g, fry Semen Celosiae 12g, Fructus Lycii 11g, Fructus Gardeniae 12g, Spica Prunellae 12g, Fructus Ligustri Lucidi 12g, Radix Paeoniae Alba 11g, Folium Mori 11g, Flos Eriocauli 12g, Flos Chrysanthemi 11g, Cortex Moutan 11g, Radix Polygoni Multiflori Preparata 12g, Herba Ecliptae 12g, Radix Astragali 12g, be prepared into health tea by embodiment 2 method, every day two bags, boiled water is taken after mixing it with water, and uses and looks into afterwards for one month, the dry astringent situation of readme eyes is clearly better, and appearance yellowing of the skin day by day disappears, and receives increasing; The mental status, complexion is obviously improved, and mottle slowly disappears.Evening, sleep improvement continued.Take Chinese medicine tea-drinking of the present invention 4 months, symptom all disappears.Still continue now to use.
Claims (10)
1. a Radix Salviae Miltiorrhizae leaf health-care tea for liver heat removing and eyesight improving, is characterized in that, described health tea comprises the raw material of following parts by weight: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, fry Semen Celosiae 10 ~ 20 parts, Fructus Lycii 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, 10 ~ 20 parts, Folium Mori, Flos Eriocauli 10 ~ 20 parts, Flos Chrysanthemi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.
2. the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving according to claim 1, it is characterized in that, in described health tea, the parts by weight of various raw material are: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, fry Semen Celosiae 10 ~ 15 parts, Fructus Lycii 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Spica Prunellae 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, 10 ~ 20 parts, Folium Mori, Flos Eriocauli 10 ~ 20 parts, Flos Chrysanthemi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.
3. the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving according to claim 1, it is characterized in that, in described health tea, the parts by weight of various raw material are: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, fry Semen Celosiae 10 ~ 20 parts, Fructus Lycii 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, 10 ~ 15 parts, Folium Mori, Flos Eriocauli 10 ~ 15 parts, Flos Chrysanthemi 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Herba Ecliptae 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts.
4. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described Radix Salviae Miltiorrhizae leaf health-care tea comprises following aspect:
A.9-10 Radix Salviae Miltiorrhizae leaf is plucked the middle of the month, parch;
B. the Radix Salviae Miltiorrhizae leaf fried is kneaded, Titian;
C. other raw material pulverizing described, immersion ethanol are added extraction heat;
D. again by surplus stock extract medical filtration, be condensed into granule, powder or unguentum;
E. concentrated granule, powder or unguentum are mixed with the Radix Salviae Miltiorrhizae leaf prepared, sterilizing is prepared into health care medicinal tea.
5. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving according to claim 4, is characterized in that, in described step a, and the fresh and tender Radix Salviae Miltiorrhizae leaf of 9-10 picked by hand in the middle of the month, dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.
6. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving according to claim 4, is characterized in that, in described step b, kneaded by the Radix Salviae Miltiorrhizae leaf fried, then put into fragrance extracting machine Titian 20-30 minute, naturally dries after taking out.
7. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving according to claim 4, is characterized in that, in described step c, get other raw materials clean dry, in 70 DEG C of baking ovens, dry 8-12h, taking-up is placed in cooling in drying baker, pulverizes 80-100 mesh sieve with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.
8. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving according to claim 4, it is characterized in that, in described steps d, paste extract is placed in 70-90% ethanol and soaks 1-2 hour, 60 DEG C-70 DEG C are heated in water-bath, lixiviate 2h, every 10min stirs once, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state filtrate, then insert in economic benefits and social benefits vacuum concentrator, the unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.
9. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of liver heat removing and eyesight improving according to claim 4, is characterized in that, in described step e, mixed by the Radix Salviae Miltiorrhizae leaf made, pack after ultraviolet ray sterilization bactericidal with other raw materials of refinement.
10. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of a liver heat removing and eyesight improving according to any one of claims 1 to 3, it is characterized in that, the preparation process of all the other raw materials can also be: get other raw materials and clean roguing, steep in the ethanol of 5-10 times amount, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill; Filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105767359A (en) * | 2016-03-21 | 2016-07-20 | 廖辉 | Eyesight improving and throat moistening tea |
| CN105795271A (en) * | 2016-03-30 | 2016-07-27 | 黄山树德堂食品饮料有限公司 | Stomach moistening and detoxifying healthy beverage and preparation method thereof |
| CN105831348A (en) * | 2016-04-27 | 2016-08-10 | 天津延生园生物科技有限公司 | Salvia miltiorrhiza leaf black tea and preparation method thereof |
| CN105853773A (en) * | 2016-03-30 | 2016-08-17 | 黄山树德堂食品饮料有限公司 | Chrysanthemum health tea with heat clearing, internal heat removing, liver calming and eyesight improving efficacy, and production method thereof |
| CN106720636A (en) * | 2016-12-20 | 2017-05-31 | 潜山县彭河幸福茶场 | A kind of enriching yin and nourishing kidney health preserving tea and its production technology |
| CN108606119A (en) * | 2016-12-13 | 2018-10-02 | 天津延生园生物科技有限公司 | A kind of Radix Salviae Miltiorrhizae leaf compounded health tea for improving sleep |
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| CN101700305A (en) * | 2009-11-10 | 2010-05-05 | 陈卫 | Pill for clearing liver and improving vision |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101700305A (en) * | 2009-11-10 | 2010-05-05 | 陈卫 | Pill for clearing liver and improving vision |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105767359A (en) * | 2016-03-21 | 2016-07-20 | 廖辉 | Eyesight improving and throat moistening tea |
| CN105795271A (en) * | 2016-03-30 | 2016-07-27 | 黄山树德堂食品饮料有限公司 | Stomach moistening and detoxifying healthy beverage and preparation method thereof |
| CN105853773A (en) * | 2016-03-30 | 2016-08-17 | 黄山树德堂食品饮料有限公司 | Chrysanthemum health tea with heat clearing, internal heat removing, liver calming and eyesight improving efficacy, and production method thereof |
| CN105831348A (en) * | 2016-04-27 | 2016-08-10 | 天津延生园生物科技有限公司 | Salvia miltiorrhiza leaf black tea and preparation method thereof |
| CN108606119A (en) * | 2016-12-13 | 2018-10-02 | 天津延生园生物科技有限公司 | A kind of Radix Salviae Miltiorrhizae leaf compounded health tea for improving sleep |
| CN106720636A (en) * | 2016-12-20 | 2017-05-31 | 潜山县彭河幸福茶场 | A kind of enriching yin and nourishing kidney health preserving tea and its production technology |
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