CN105616318A - Anti-wrinkle and skin-firming herba centellae traditional Chinese medicine facial mask and preparation method therefor - Google Patents

Abstract

The invention provides an anti-wrinkle and skin-firming herba centellae traditional Chinese medicine facial mask. The facial mask comprises the following raw herbs in parts by weight: 10-50 parts of herba centellae, 10-20 parts of radix polygonati officinalis, 10-20 parts of radix angelicae sinensis, 10-20 parts of herba leonuri, 10-20 parts of rhizoma ligustici chuanxiong, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of peach kernels, 10-20 parts of radix ginseng, 10-20 parts of flos carthami, 10-20 parts of pearl, 10-20 parts of bletilla striata, 10-20 parts of syringa oblatavar alba, 10-20 parts of pyracantha fortuneana fruit, 10-20 parts of radix ampelopsis, 10-20 parts of radix angelicae, 10-20 parts of white muscardine silkworm, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of radix et rhizoma nardostachyos,10-20 parts of calendula officinalis and 10-20 parts of geranium. According to the facial mask, a connecting part of the epidermis and the dermis can be firmed, the skin can become soft, and the skin slack phenomenon can be eliminated to enable the skin to be smooth and elastic; the formation of collagens in a dermis layer is prompted and fibrins are regenerated and reconnected so as to enable the skin to be firm and smooth.

Description

A kind of Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm and preparation method thereof

Technical field

The present invention relates to containing the beauty treatment preparation deriving from plant, animal or mineral component, particularly to the Herba Centellae face mask of traditional Chinese medicine and preparation method thereof of a kind of crease-resistant Firm.

Background technology

Chinese medicine beauty treatment is under the guidance of Chinese medicine rationale, by using beauty treatment oral medicinal herb or the outer a kind of method being used for recovering or improve the physiological function of body. Interior oral administration, from internal benefiting vital QI and blood, adjustment function, makes people's QI and blood abundant, radiant. Outer usage be use medicine directly act on body surface local, it utilizes the performance of medicine, make QI and blood flowing, unimpeded through gas, with reach beauty treatment health care effect. Compared with chemical toilet, Chinese medicine beauty treatment has outstanding feature and advantage. One is that Chinese medicine beauty treatment combines together with Chinese medicine, has significantly functional, and its principle is the same with Chinese medicine, focuses on overall conditioning, emphasizes first to nurse one's health inherence, then will shape in outward, therefore, cosmetic result persistently, stable. Two is with theory of Chinese medical science for instructing, and has theory of Chinese medical science feature, such as organic conception, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, property theory, compound compatibility, has the thinking different from modern cosmetics. Three is have pure natural property, Chinese medicine in cosmetic sunscreen relatively synthetic there is uniqueness and significant advantage, there is the features such as nontoxic, harmless, not carcinogenic.

The beauty treatment Chinese medicine summing up out up to now kind more than totally 300, nearly thousand kinds of prescription of improving looks, its elite can provide effective natural drug therapy for modern beauty. Radix Angelicae Sinensis, Radix Ginseng, the Radix Angelicae Dahuricae, Semen Coicis, Semen Armeniacae Amarum, Semen Persicae, Fructus Lycii, Cortex Phellodendri, Flos Inulae, Rhizoma Typhonii, Rhizoma Chuanxiong, Bulbus Lilii, Radix Salviae Miltiorrhizae, Semen Euryales etc. are all more common beauty treatment Chinese medicine. Wherein Radix Angelicae Sinensis is warm in nature, sweet in the mouth, pungent. There is the effect invigorated blood circulation, enrich blood, blood circulation, skin nutrition can be accelerated, make skin health ruddy. Radix Ginseng contains volatile oil, ginsenoside, polysaccharide, multiple low molecular peptide aminoacid, the composition such as vitamin B group, vitamin C, can improve the blood circulation of local skin, strengthen the supply of skin-nourishing material, promote the metabolism of skin, keep the bright and clean and moist of skin, thus the effect of delay skin aging can be played.

Semen Armeniacae Amarum is warm in nature, bitter in the mouth. The moist skin of energy, hair and tonneau mechanism of qi, ancients are concocted with Semen Armeniacae Amarum, and every early empty stomach is taken, for a long time with there being the merit prolonged life of preserving youthful looks. Margarita is in all age always up the skin protection conditioning skin and losing good merchantable brand that people like, skin can be made fine and smooth, and color is ruddy, without wrinkle. Margarita powder is just often swallowed with conditioning skin and losing according to passing Qing Dynasty the Empress Dowager. Rhizomadioscoreae, Semen Nelumbinis, Bulbus Lilii, Fructus Jujubae all energy strengthening the spleen and nourishing the stomach, nourishing blood to tranquillize the mind so that the moist fitness of skin. The promoting blood flow and remove blood stasis drug such as Flos Carthami, Semen Persicae has and improves skin microcirculation effect, so that the QI and blood of people fills Sheng, radiant. Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae can moisten and cleaning skin, dispel skin chloasma and black speck, it is suppressed that seborrheic dermatitis, skin is had delaying senility function. Application Chinese medicine is improved looks, and for oral administration have decoction, powder, unguentum, a medicated wine, and medicinal diet for beautifying etc. Life traditional Chinese medicinal meals cosmetic applications is more, and this is based on the theory of the traditional Chinese medical science " doctor food homology, integration of edible and medicinal herbs " in fact, and the medicine selecting some effect relevant becomes food with food formulation, to reach beauty treatment and the double effects of health care. External is washed, is smoked, and facial film applies, more with facial film application again.

Herba Centellae, for perennial draft of crawling. Another name: 18 lack, collapse jorum, Herba Calthae Membranaceae, Gotu Kola, Carnis Arca inflata shell grass, Hydrocotyle vulgaris L., tiger grass, Herba sambuci chinensis etc. Be born in by dark and damp wasteland, village, roadside, limit, ditch. Stem is thrown oneself on the ground, and joint is taken root. Leaf alternate, petiole is long; Blade circle or kidney shape, diameter 2��4 centimetres. Clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating. Controlling eruptive disease stomachache, diarrhea due to summer-heat, dysentery, jaundice due to damp-heat, sand Stranguria, stranguria with blood, tell, be defeated in battle, hemoptysis, conjunctival congestion, larynx swells, rubella, scabies, furuncle carbuncle poison, traumatic injury.

Pharmacological action: to maincenter effects on neural system

Mice, rat are had calmness, stable effect by glycoside contained therein, and this effect is mainly the impact on the cholinergic system in central nervous system. Alcohol extract is without analgesic activity.

Effect to skin histology

Asiaticoside can treat skin ulcer, such as intractable wound, tuberculosis of skin, leprosy etc. To mice, Cavia porcellus, rabbit muscle are injected or are subcutaneously implanted and can promote skin growth, the Acceleration of growth etc. of local leukocytosis, connective tissue coil pipe net hypertrophy, mucous secretion increase, hair and tail. Once had report with containing Herba Centellae 0.25��1% alcohol extract (containing asiatic acid, Asiaticoside) cream (wherein still containing embryo's or calf, pig or Corii Caprae seu Ovis skin, liver, brain water-alcohol extraction) treat dermatosis, obtain good result.

Beautification function

Herba Centellae has a heat-clearing and toxic substances removing, inducing diuresis and reducing edema, nourishing, antiinflammatory, quelling effect. Deep skin cell can be stimulated to substitute. Herba Centellae can be compacted epidermis and corium coupling part, skin can be made to limber up, contribute to solving cutis laxa phenomenon, make skin smooth flexible; Promoting that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, and makes skin reach smooth effect of compacting. Also assist in impaired organization healing and consolidation skin. Being closely connected between epidermis with corium can be promoted, the increase of adipose cell can be suppressed again, it is prevented that hydroderma, appearance obesity.

Herba Centellae is applicable to various skin quality, and the water extract of its plumelet has the effect of anti-inflammation, and it belongs to dicotyledon Umbelliferae, and energy subduing swelling and detoxicating is dispelled abscess.

Antibacterial action

The water extract of plumelet has antibacterial action. Asiaticoside can treat leprosy, it is believed that it act as the cere of dissolution of bacteria, thus being eliminated by other drug or body defenses function.

Other effects

Alcohol extract can relax isolated rat ileum. Glycoside part can reduce tension force and the shrinkage amplitude of rabbit and isolated rat ileum, and can slightly suppress the effect of acetylcholine. To anesthetized dog, intravenous injection can slightly excited be breathed, and heart rate is slack-off and the reducing blood pressure of moderate, and the latter two can not by That atropine blocks.

Summary of the invention

The technical problem to be solved is in that, Chinese medicine beauty treatment is under the guidance of Chinese medicine rationale, by using beauty treatment oral medicinal herb or the outer a kind of method being used for recovering or improve the physiological function of body. Interior oral administration, from internal benefiting vital QI and blood, adjustment function, makes people's QI and blood abundant, radiant. Outer usage be use medicine directly act on body surface local, it utilizes the performance of medicine, make QI and blood flowing, unimpeded through gas, with reach beauty treatment health care effect. Compared with chemical toilet, Chinese medicine beauty treatment has outstanding feature and advantage.

For solving these technical barriers, the invention provides the Herba Centellae face mask of traditional Chinese medicine of a kind of crease-resistant Firm, its described face mask of traditional Chinese medicine includes the crude drug of following parts by weight: Herba Centellae 10��50 parts, Rhizoma Polygonati Odorati 10��20 parts, Radix Angelicae Sinensis 10��20 parts, Herba Leonuri 10��20 parts, Rhizoma Chuanxiong 10��20 parts, Radix Salviae Miltiorrhizae 10��20 parts, 10��20 parts of Semen Persicae, Radix Ginseng 10��20 parts, 10��20 parts of Flos Carthami, Margarita 10��20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Faeces Passeris 10��20 parts, pyracantha fortuneana 10��20 parts, Radix Ampelopsis 10��20 parts, the Radix Angelicae Dahuricae 10��20 parts, Bombyx Batryticatus 10��20 parts, the Rhizoma Atractylodis Macrocephalae 10��20 parts, Radix Et Rhizoma Nardostachyos 10��20 parts, Flos Inulae 10��20 parts, Flos Pelargonii 10��20 parts.

The Herba Centellae face mask of traditional Chinese medicine of described crease-resistant Firm, its described face mask of traditional Chinese medicine can include the crude drug of following parts by weight: Herba Centellae 10��30 parts, Rhizoma Polygonati Odorati 10��15 parts, Radix Angelicae Sinensis 10��15 parts, Herba Leonuri 10��15 parts, Rhizoma Chuanxiong 10��15 parts, Radix Salviae Miltiorrhizae 10��15 parts, 10��15 parts of Semen Persicae, Radix Ginseng 10��15 parts, 10��15 parts of Flos Carthami, Margarita 10��15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Faeces Passeris 10��20 parts, pyracantha fortuneana 10��20 parts, Radix Ampelopsis 10��20 parts, the Radix Angelicae Dahuricae 10��20 parts, Bombyx Batryticatus 10��20 parts, the Rhizoma Atractylodis Macrocephalae 10��20 parts, Radix Et Rhizoma Nardostachyos 10��20 parts, Flos Inulae 10��20 parts, Flos Pelargonii 10��20 parts.

The Herba Centellae face mask of traditional Chinese medicine of described crease-resistant Firm, its described face mask of traditional Chinese medicine can also include the crude drug of following parts by weight: Herba Centellae 10��40 parts, Rhizoma Polygonati Odorati 10��20 parts, Radix Angelicae Sinensis 10��20 parts, Herba Leonuri 10��20 parts, Rhizoma Chuanxiong 10��20 parts, Radix Salviae Miltiorrhizae 10��20 parts, 10��20 parts of Semen Persicae, Radix Ginseng 10��20 parts, 10��20 parts of Flos Carthami, Margarita 10��20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Faeces Passeris 10��15 parts, pyracantha fortuneana 10��15 parts, Radix Ampelopsis 10��15 parts, the Radix Angelicae Dahuricae 10��15 parts, Bombyx Batryticatus 10��15 parts, the Rhizoma Atractylodis Macrocephalae 10��15 parts, Radix Et Rhizoma Nardostachyos 10��15 parts, Flos Inulae 10��15 parts, Flos Pelargonii 10��15 parts.

For solving above-mentioned technical problem, the preparation method that the present invention also provides for the Herba Centellae face mask of traditional Chinese medicine of a kind of crease-resistant Firm, it is characterised in that described preparation method comprises the following steps:

A. the preparation of Herba Centellae, extracts, as component 1;

B. take Radix Et Rhizoma Nardostachyos, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 2;

C. all the other crude drug are removed Margarita external ethanol extraction 2 times, merge concentrated extracting solution, as component 3;

D., the Margarita that component 1, component 2 add after mixing with component 3 pulverizing is in harmonious proportion with Cera Flava, and sterilize tinning.

In described step a, it is possible to take the Herba Centellae chopping will plucked spring and summer, cross 80-100 mesh sieve.

In described step a, it is possible to the step farther including to extract is to be placed in by medicated powder in lid stainless steel cask, adds 70% ethanol, and quality is 0.8-1 times of coarse powder, stirs, moistening airtight placement more than 1 hour, make abundant expansion; Drug sample after moistening expansion is mixed after paving pine by filter plate gauze bag parcel again bottom percolator do to dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, 2/3 eminence that must not exceed percolator loaded by medicated powder; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow 2��3ml per minute, filtrate puts into liquid container, and ethanol during by emptying pours liquid container into; Percolate is merged and stands. Heating is concentrated into paste, stand for standby use, becomes component 1.

In described step b, it is possible to take Radix Et Rhizoma Nardostachyos, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverized 120-150 order dusting cover stand-by, as component 2.

In described step c, all the other raw materials described can be added soak with ethanol 4-6 hour that accounts for its quality 5-10 times amount except Margarita, heating extraction 2 times, each 1-2 hour, united extraction liquid, supernatant is removed after standing, then 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, standing is put in economic benefits and social benefits vacuum concentrator and is mixed, and first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, then inserts 0��5 DEG C of deepfreeze 24 hours; The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, as component 3.

In described step d, it is possible to first blending ingredients 1, component 2 stir with component 3, then by crossing 120-150 order dusting cover after crushing pearl, pouring into and wherein stir, add Cera Flava and make facial film, ultraviolet sterilization is bottled.

For solving above-mentioned technical problem, the present invention reoffers the using method of the Herba Centellae face mask of traditional Chinese medicine of a kind of crease-resistant Firm, can after each face cleaning just before going to bed, by facial film uniform application in face, and by middle finger finger belly face message 15-20 minute, after fully absorbing to it, wash away after half an hour, can use 3-4 time weekly.

The present invention is with reference to the achievement of Chinese medicine pharmacological research at all times, the natural Chinese medicine that screening Glycerin, inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, detumescence dewater, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolism function of human body, improve human facial skin's blood circulation, thus reaching to remove wrinkle, compact skin, eliminate skin texture, detumescence blood stasis dispelling, fatigue alleviating, the skin around the eyes that compacts, desalination eye pouch, reduce wrinkle, beautify the purpose of appearance. The present invention can stimulate deep skin cell to substitute. Herba Centellae can be compacted epidermis and corium coupling part, skin can be made to limber up, contribute to solving cutis laxa phenomenon, make skin smooth flexible; Promoting that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, and makes skin reach smooth effect of compacting. Also assist in impaired organization healing and consolidation skin.

Detailed description of the invention

Chinese medicine beauty treatment is under the guidance of Chinese medicine rationale, by using beauty treatment oral medicinal herb or the outer a kind of method being used for recovering or improve the physiological function of body. Interior oral administration, from internal benefiting vital QI and blood, adjustment function, makes people's QI and blood abundant, radiant. Outer usage be use medicine directly act on body surface local, it utilizes the performance of medicine, make QI and blood flowing, unimpeded through gas, with reach beauty treatment health care effect. Compared with chemical toilet, Chinese medicine beauty treatment has outstanding feature and advantage. One is that Chinese medicine beauty treatment combines together with Chinese medicine, has significantly functional, and its principle is the same with Chinese medicine, focuses on overall conditioning, emphasizes first to nurse one's health inherence, then will shape in outward, therefore, cosmetic result persistently, stable. Two is with theory of Chinese medical science for instructing, and has theory of Chinese medical science feature, such as organic conception, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, property theory, compound compatibility, has the thinking different from modern cosmetics. Three is have pure natural property, Chinese medicine in cosmetic sunscreen relatively synthetic there is uniqueness and significant advantage, there is the features such as nontoxic, harmless, not carcinogenic.

The beauty treatment Chinese medicine summing up out up to now kind more than totally 300, nearly thousand kinds of prescription of improving looks, its elite can provide effective natural drug therapy for modern beauty. Radix Angelicae Sinensis, Radix Ginseng, the Radix Angelicae Dahuricae, Semen Coicis, Semen Armeniacae Amarum, Semen Persicae, Fructus Lycii, Cortex Phellodendri, Flos Inulae, Rhizoma Typhonii, Rhizoma Chuanxiong, Bulbus Lilii, Radix Salviae Miltiorrhizae, Semen Euryales etc. are all more common beauty treatment Chinese medicine. Wherein Radix Angelicae Sinensis is warm in nature, sweet in the mouth, pungent. There is the effect invigorated blood circulation, enrich blood, blood circulation, skin nutrition can be accelerated, make skin health ruddy. Radix Ginseng contains volatile oil, ginsenoside, polysaccharide, multiple low molecular peptide aminoacid, the composition such as vitamin B group, vitamin C, can improve the blood circulation of local skin, strengthen the supply of skin-nourishing material, promote the metabolism of skin, keep the bright and clean and moist of skin, thus the effect of delay skin aging can be played.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, QI-blood circulating regularly freely balances as expensive, if QI and blood is not smooth will produce blood stasis, blood stasis hinders in internal, will further result in the deterioration of qi-blood circulating, cause more serious stasis of blood plug, therefore the traditional Chinese medical science is with QI and blood for guiding principle, by regulating qi and activating blood so as to smoothness balances, can disease-relieving and physique enhancing, beauty treatment of nourishing blood. Skin speckle basic in the stasis of blood, move back speckle must first blood stasis dispelling, blood stasis dispelling when invigorating blood circulation, invigorate blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood runs therewith; Blood is keeping of gas, that be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy then blood prostration, and gas is compeled then blood and walked. QI and blood and then all and. And regulate the flow of vital energy liver, QI invigorating is at lung kidney, lung governing skin and hair. Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, and cause face and occur alopecia, alopecia areata even occurring the mottles such as chloasma, black eye, eye pouch, eye edema, freckle.

Herba Centellae, for perennial draft of crawling. Another name: 18 lack, collapse jorum, Herba Calthae Membranaceae, Gotu Kola, Carnis Arca inflata shell grass, Hydrocotyle vulgaris L., tiger grass, Herba sambuci chinensis etc. Be born in by dark and damp wasteland, village, roadside, limit, ditch. Stem is thrown oneself on the ground, and joint is taken root. Leaf alternate, petiole is long; Blade circle or kidney shape, diameter 2��4 centimetres. Clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating. Controlling eruptive disease stomachache, diarrhea due to summer-heat, dysentery, jaundice due to damp-heat, sand Stranguria, stranguria with blood, tell, be defeated in battle, hemoptysis, conjunctival congestion, larynx swells, rubella, scabies, furuncle carbuncle poison, traumatic injury.

Pharmacological action: to maincenter effects on neural system

Mice, rat are had calmness, stable effect by glycoside contained therein, and this effect is mainly the impact on the cholinergic system in central nervous system. Alcohol extract is without analgesic activity.

Effect to skin histology

Asiaticoside can treat skin ulcer, such as intractable wound, tuberculosis of skin, leprosy etc. To mice, Cavia porcellus, rabbit muscle are injected or are subcutaneously implanted and can promote skin growth, the Acceleration of growth etc. of local leukocytosis, connective tissue coil pipe net hypertrophy, mucous secretion increase, hair and tail. Once had report with containing Herba Centellae 0.25��1% alcohol extract (containing asiatic acid, Asiaticoside) cream (wherein still containing embryo's or calf, pig or Corii Caprae seu Ovis skin, liver, brain water-alcohol extraction) treat dermatosis, obtain good result.

Beautification function

Herba Centellae has a heat-clearing and toxic substances removing, inducing diuresis and reducing edema, nourishing, antiinflammatory, quelling effect. Deep skin cell can be stimulated to substitute. Herba Centellae can be compacted epidermis and corium coupling part, skin can be made to limber up, contribute to solving cutis laxa phenomenon, make skin smooth flexible; Promoting that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, and makes skin reach smooth effect of compacting. Also assist in impaired organization healing and consolidation skin. Being closely connected between epidermis with corium can be promoted, the increase of adipose cell can be suppressed again, it is prevented that hydroderma, appearance obesity.

Herba Centellae is applicable to various skin quality, and the water extract of its plumelet has the effect of anti-inflammation, and it belongs to dicotyledon Umbelliferae, and energy subduing swelling and detoxicating is dispelled abscess.

Flos Pelargonii stops blooding, vasoconstrictive, asthma, liver and expelling toxin, cholelithiasis, kidney toxin expelling, renal calculus, diuresis, muscular soreness, oily skin, aging skin activates, herpes, palor, fat-reducing, promotes to scab, eczema, sunburn of burning, tinea, menstruation has some setbacks, engorgement of breasts inflammation, alleviates melancholy uneasy, drives demon, mend body, deodorization, antibacterial, sterilization, give up smoking (wine). the major function of Flos Pelargonii is in that to adjust skin, and the effective ingredient in Flos Pelargonii extracting solution and natural alicyclic organic have very strong affinity, and therefore, Flos Pelargonii is often combined with alicyclic organic and makes lipoid product. general cleaning supplies are after cleaned, the functional components major part of skin protection can be flush with water loss, the scientific research personnel of Switzerland is on the basis of three-hypers fresh extractor technology, select to hands sections such as organized enzymes by adding, the effective ingredient making Flos Pelargonii also produces affinity with skin epidermal area while affine with lipoid, this affinity has surmounted the affinity with water, therefore, in the process cleaned, most of effective ingredient of Flos Pelargonii still is able to be absorbed by the skin, play the effect adjusting skin, Flos Pelargonii is almost suitable for various skin, because it can balance sebum secretion and make turgor. be likely to eczema, burn, herpes zoster, herpes, tinea and chilblain useful. slack and undisciplined, pore is blocked and oily skin is also fine, due to Flos Pelargonii can pore refining, blood circulation promoting, can allow after using pale skin is comparatively ruddy vigor, make the glossy exquisiteness of skin.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant. Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, and married woman's blood closes obstructed, repercussive blood, can lose pus, benefit woman's blood. " Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, bring down a fever, relieving restlessness, QI invigorating, the hot disease of sky row, and pestilence miasma, mania and irritation, married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula. Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat. The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold. Return lung, liver, stomach warp. Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation. Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage. Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature. Attach to the lung and stomach meridians. Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping. " Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.

Radix Salviae Miltiorrhizae is bitter, is slightly cold. GUIXIN, Liver Channel. Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness. For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia. For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc. Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea has good effect. " detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, and all generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same. Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins. Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has expansion blood vessel, improves circulation, releases the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, is beneficial to liver cell regeneration.

Flos Carthami (Classification system: CarthamustinctoriusL.), another name: red blue flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium, dry tubular flower, orange red, floral tube is narrow carefully, and tip 5 splits, and sliver is narrow linear, flower pesticide yellow, being unified into pipe, exceed outside sliver, its central authorities have stigma to expose. Have special fragrance, mildly bitter flavor. To spend, length of a film, color be scarlet, the soft person of matter is preferred. Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, breast side of body twinge, traumatic injury, skin infection swell and ache curative effect. Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen.

Semen Persicae (SemenPersicae), can refer to the core youngster in Semen Persicae; When using as Chinese herbal medicine Semen Persicae, refer in particular to the seed of rosaceous plant Fructus Persicae or Prunus davidiana, another name Radix Fici Hirtae core, almond core, big Semen Persicae, pluck during fruit maturation in 6��July, remove sarcocarp and nucleocapsid, take out seed, dry, there is effect of blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, can be used for amenorrhea, dysmenorrhea, abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation etc. Anemia of pregnant woman is cautious use of. Clinical observation proves, blood flow is blocked by Semen Persicae, blood obstacle has improvement result, and each internal organs can be made respectively to organize functional recovery normal.

Pyracantha fortuneana, fire spine (Pyracanthafortuneana (Maxim.) Li), it is used as medicine with fruit, root, leaf, property is put down, sweet in the mouth, acid, leaf energy heat-clearing and toxic substances removing, sore swollen toxin is controlled in external application, firethorn fruit contains abundant organic acid, protein, aminoacid, vitamin and multiple mineral element, can eat raw, it is possible to be processed into various beverage. Its fruit is ripe for autumn, like torch, can make shade tree or garden is planted. Its root bark, peel of stem, fruit, containing abundant tannin, can be used to extract tanning material. Fire spine root can be used as medicine, and its nature and flavor are pained, the effect such as have antidiarrheal, dissipating blood stasis, help digestion, and fruit, leaf, peel of stem also have similar drug effect. Fire spine leaves can tea making, there is heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, astringing to arrest diarrhea effect. Containing the active substance suppressing dental caries in Fructus Pyracanthae, human teeth preventing and treating there is is positive effect, be again the quality raw materials making toothpaste. During Taiwan Fructus Pyracanthae is red bright exquisite in pearl, because taste is otherwise known as " pocket Fructus Mali pumilae " like Fructus Mali pumilae, " king of micro-fruit ". One its ascorbic content of the Fructus Pyracanthae such as pearl is equivalent to a Big Apple, is the high health fruit of nutrition. Scientific research finds, containing biological whitening substance in Fructus Pyracanthae, can effectively suppress the vigor of various pigment enzymes in human body, make skin not chromogenesis. Fructus Pyracanthae extracting solution is widely used in cosmetics, rich in natural fire spine elite, can reach skin bottom, from inside to outside deep layer whitening, and moisturizing is effectively improved obscure dry-out phenomenon.

Herba Leonuri acrid in the mouth is bitter, cool, invigorates blood circulation, silt of dispelling, regulating menstruation, disappear water, treats menoxenia, and vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection. Herba Leonuri has inducing diuresis to remove edema, shrinks the effect of uterus effect, is that ancient Chinese medicine doctor is for treating gynopathic key medicine. Herba Leonuri can all herbal medicine, effective ingredient be Herba Leonuri element, Herba Leonuri is containing multiple alkaloid and benzoic acid, potassium chloride etc. such as leonurine, stachydrine, leonuridine, leonurinines. Motherwort formulation has the effect of excited animal uterus, similar to pituitrin, and there is strong and lasting excitation in uterus by Herba Leonuri extractum and decoct, not only can strengthen its contractility, can improve its tensity and shrinkage factor simultaneously.

Radix Ampelopsis is the root of vitaceae Radix Ampelopsis, and annual spring, autumn excavate, and removes stem and thin fibrous root, and after cleaning, many rip cuttings become two lobes, pintongs or inclined tab, dry and can be used as medicine. It is cool in nature, and bitter but sweet flavor is pungent, has effect of heat clearing away, removing toxic substances, eliminating stagnation, granulation promoting, pain relieving, is used for treating the diseases such as carbuncle, furuncle, scrofula, scald, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula.

The superfine product of " king of BAICAO " " YIN nourishing is mended raw, strengthening the body resistance " is described as by Radix Ginseng from ancient times, containing multiple Saponin and polysaccharide composition, leachate can slowly be absorbed by skin and without pessimal stimulation, energy skin expansion blood capillary, promote cutaneous circulation, increase skin-nourishing, the water and oil balance of regulation of skin, it is prevented that skin dehydration, hardening, wrinkling, Radix Ginseng active substance suppresses melanic reducing property, make skin pure white smooth, skin elasticity can be strengthened, make cell obtain new life, be the superfine product improved looks. Radix Ginseng is directly immersed in 50% glycerol, and after 10 days, face rubbed with the hands by glycerol, or Radix Ginseng is decocted into extract, and every day toward face washing water a bit, rubs face or Radix Ginseng water face-washing with the hands, skin can be allowed quite moist with the glycerol containing Radix Ginseng.

Rhizoma Polygonati Odorati, formal name used at school: Polygonatumodoratum (Mill.) Druce, for Liliaceae herbaceos perennial. Rhizome horizontal walk, meat yellow-white, close raw most fibrous roots. Rhizoma Polygonati Odorati is extracted flavonoid substances and is combined a kind of novel substance of formation-wash pancreas sugar plain (cics) clearly with Folium Mori extract deoxynojirimycin, has blood sugar lowering, blood fat, blood pressure etc. and acts on. Rhizoma Polygonati Odorati tool yin nourishing, moisturize, heat clearing away, promote the production of body fluid, the effect such as cough-relieving. As tonic, cure mainly the diseases such as consumption of YIN caused by febrile disease, deficiency-heat cough caused by dryness, heart disease, diabetes, tuberculosis, and high-grade nourishing food, delicacies and beverage can be made, with health role.

Radix Et Rhizoma Nardostachyos acrid in the mouth, sweet, warm in nature. Return spleen, stomach warp. Effect regulating QI to relieve pain, relieving stagnation and activating the spleen, external damp eliminating is subsided a swelling. Cure mainly for distension and fullness in the abdomen, inappetence, vomiting; Toothache, beriberi toxic swelling are controlled in external. " book on Chinese herbal medicine is looked for the truth ": Radix Et Rhizoma Nardostachyos, though there being class Rhizoma Kaempferiae, but how pungent Rhizoma Kaempferiae gas is alters, and this is then sweet more than pungent, therefore book load can enter spleen dissipating depression of QI also.

Margarita is medicinal in China's history of existing more than 2000 years. Medical book " Mingyi Bielu " during three states, " book on Chinese herbal medicine is through the collection " in beam generation, " Haiyao Bencao, Oversea Materia Medica " of the Tang Dynasty, " Kaibao Bencao " of Song dynasty, the Compendium of Material Medica of the Ming Dynasty, the Qing Dynasty 19 kinds of medical ancient books such as Leigon's Nature of Drugs in Songs, all the curative effect of Margarita is had clear and definite record. Beam is said in " book on Chinese herbal medicine through collection " for TAO Hong-Jing, and Margarita " is controlled order skin nebula, stopping leak " etc. and acts on. " Haiyao Bencao, Oversea Materia Medica " of the Tang Dynasty is thought, Margarita can improving eyesight, except dizzy, stopping leak. In the Yuan Dynasty, tradespeople is everlasting in water to add Mel and Margarita powder is drunk, it is believed that it both can nourish, again can sunstroke prevention. Unit is great curiosity to ask all sorts of questions to be recorded in " continuous smooth hard will ": " the wash one's face water winter ties little ice ... circle is clean such as pearl ... midsummer adjusts it with mulse, adds Margarita powder. " Ming Dynasty's Li Shizhen (1518-1593 A.D.) payes attention to the pharmacological action of Margarita more, it is believed that the drug effect of Margarita is at skin Caring, thus writes especially in Compendium of Material Medica: " taste Cheng Ganhan is nontoxic for Margarita, relieving palpitation point order; Margarita is coated with face, makes us moist good color. It is coated with brothers, removes the peel skin hangnail; Pendant expectorant, except speckle, antidiarrheal; Except children's's fever (of children) accompanied by fear, pacify soul; Stop nebulousurine of passing out semen, solve pox and treat poison. ... make the gloss pure white " etc. Meanwhile, it is also stated that the medicinal multiple method of Margarita.

The pungent one-tenth of Bombyx Batryticatus is flat. Enter liver, lung, stomach warp. Function cures mainly expelling wind to relieve convulsion, dissipating phlegm and resolving masses. Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble. Sore throat, scrofula tuberculosis. " herbal classic ": main pediatric epilepsy scared night cry, goes three worms, goes out black, and man's the moon infections is sick. " not Lu ": woman's metrorrhagia is red in vain, puerperal remaining pain, all skin ulcer cicatrixs of going out. " detailed outline ": dissipating wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer, erysipelas is had an itch, intermittent fever due to phlegm crux, married woman's galactostasis, metrorrhagia hematochezia, children's's infantile malnutrition erosion squama body, all incised wounds, furuncle swells wind hemorrhoid.

The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, and for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement. " medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, antiabortive. "

Radix Angelicae Sinensis is sweet, pungent, warm returns liver, the heart, spleen channel. Function cures mainly enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation. The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Weight after bloody dysentery; Ulcer sores; Injury from falling down.

Faeces Passeris, Chinese medicine name. Feces for ploceidae animal Passeris montani saturati Passermontanus (L.). It is distributed in China several throughout whole level land. There is removing food stagnancy, effect of improving eyesight. Being usually used in gathering, hernia, corneal nebula, carbuncle furuncle, tonsillitis are controlled in external. Bitter in the mouth, warm in nature. Return liver, kidney channel removing food stagnancy, improving eyesight.

Flos Inulae, latin name (Calendulaofficinalis), have another name called Calendula officinalis, asphodel. Calendula officinalis rich in multivitamin, especially vitamin A and vitamin C, pigementation can be prevented, promote skin gloss and elasticity, delaying senility, avoid that skin is lax raw to wrinkle. Also can prevent ciril disease, such as vascular lesion and cancer, more can regulate the flow of vital energy cough-relieving, stomach invigorating, reduce phlegm, prevention of asthma and bronchitis. Almost each position can eat; Its petal has the function of beauty treatment, and flower is containing carotenoid, lycopene, violaxanthin, rubixanthin, volatile oil, resin, lymphatic temperament, malic acid etc. Root is containing amaroid, mountain gold east glycol; Seed is containing glyceride, ceryl alcohol and alkaloid. Putting into can so that hair color be thin out in shampoo.

Embodiment 1

Spring and summer plucks Herba Centellae, dry preparation, steeps into alcohol extraction, as component 1;

Take Radix Et Rhizoma Nardostachyos, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 2;

By all the other raw material Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Herba Leonuri, Radix Salviae Miltiorrhizae, Semen Persicae, Radix Ginseng, Flos Carthami, pyracantha fortuneana, Radix Ampelopsis, Bombyx Batryticatus, the Rhizoma Atractylodis Macrocephalae, Flos Inulae, Flos Pelargonii, Faeces Passeris ethanol extraction 2 times, merge concentrated extracting solution, as component 3;

Component 1, component 2 add after mixing with component 3 Margarita powder of pulverizing, and Cera Flava stirs, ultraviolet sterilization tinning.

Embodiment 2:

Herba Centellae can be plucked during spring and summer, by Herba Centellae 5000g chopping good for dry in the sun, cross 100-120 mesh sieve, being equipped with by medicated powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, make abundant expansion, drug sample after moistening expansion is mixed after paving pine by filter plate gauze bag parcel again bottom percolator do to dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, 2/3 eminence that must not exceed percolator loaded by medicated powder, medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol, air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow 2��3ml per minute, filtrate puts into liquid container, and ethanol during by emptying pours liquid container into, percolate is merged and stands. heating is concentrated into paste, stand for standby use, becomes component 1. Radix Et Rhizoma Nardostachyos 1500g, Rhizoma Chuanxiong 1500g, Radix Angelicae Dahuricae 1500g, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g way of distillation are vaporized into crystallization, pulverize stand-by, for component 2, again by other raw materials Rhizoma Polygonati Odorati 1500g, Radix Angelicae Sinensis 1500g, Herba Leonuri 1500g, Radix Salviae Miltiorrhizae 1500g, Semen Persicae 1500g, Radix Ginseng 1500g, Flos Carthami 1500g, pyracantha fortuneana 1500g, Radix Ampelopsis 1500g, Bombyx Batryticatus 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Flos Inulae 1500g, Flos Pelargonii 1500g, Faeces Passeris 1500g, add soak with ethanol 4-6 hour that accounts for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, united extraction liquid, supernatant is removed after standing, then 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, stand for standby use. two kinds of filtrates above-mentioned steps extracted, put in economic benefits and social benefits vacuum concentrator and mix, and first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, then inserts 0��5 DEG C of deepfreeze 24 hours, the filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, becomes component 3. component 1 is put into component 3 in component 2, stirs, Margarita 1500g is pulverized, mediation Cera Flava, stir, ultraviolet sterilization tinning.

Embodiment 3

Can plucking Herba Centellae during spring and summer, by Herba Centellae 4000g immersion water good for dry in the sun 12 hours, be then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby; Filtering residue adds water, second time heating, boils 45 minutes, filters, and filtrate is standby; Filtering residue adds water, for the third time heated and boiled half an hour, filters; Three filtrates being combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, becomes component 1; Again Radix Et Rhizoma Nardostachyos 1200g, Rhizoma Chuanxiong 1100g, Radix Angelicae Dahuricae 1200g, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1100g way of distillation are vaporized into crystallization, pulverize stand-by, for component 2; Rhizoma Polygonati Odorati 1200g again, Radix Angelicae Sinensis 1100g, Herba Leonuri 1200g, Radix Salviae Miltiorrhizae 1200g, Semen Persicae 1100g, Radix Ginseng 1200g, Flos Carthami 1200g, pyracantha fortuneana 1200g, Radix Ampelopsis 1200g, Bombyx Batryticatus 1200g, Rhizoma Atractylodis Macrocephalae 1200g, Flos Inulae 1500g, Flos Pelargonii 1200g, Faeces Passeris 1200g, is soaked in water, in raw material soaking water 12 hours, being then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby; Filtering residue adds water, second time heating, boils 45 minutes, filters, and filtrate is standby; Filtering residue adds water, for the third time heated and boiled half an hour, filters; Three filtrates are combined, by filtered through gauze, residue add 50-60% ethanol, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution, it is condensed into pasty state and becomes component 3, blending ingredients 1 and component 2 component 3, pulverize Margarita 1100g, mediation Cera Flava, stir, ultraviolet sterilization tinning.

Pharmacological toxicity is tested

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding. Medicine: facial film of the present invention.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is randomly divided into 5 groups, often group 10, male and female half and half, dissolve lotion, are made into Cmax, by the maximum allowable capacity administration of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), after animal fasting (can't help water) 18 hours, in one day, administration (interval half an hour) at twice, each 0.5ml, observe animal dead situation.

2, maximum tolerated dose measures (MTD value): take mice 20, each 10 of male and female. Tablet adds distilled water dissolve, be made into maximum concentration, by the maximum tolerated dose of animal, can twitch and be as the criterion inject filling hello device. After animal fasting (can't help water) 18 hours, administration (interval half an hour) at twice in one day, each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult's 50Kg body weight consumption. Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, seek maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death. Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, it was shown that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test of the present invention is reported

1, experiment purpose: the detection present invention is to the stimulation/corrosiveness of laboratory animal skin and intensity

2, material and method:

2.1. tested material title: facial film of the present invention (embodiment method 2 prepares)

2.2. laboratory animal: one grade of big ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;

2.3. test method:

Select the healthy rabbits 10 that skin is intact, its spinal column both sides, back were cut by hair in first 24 hours in test, the left and right each about 4cm �� 4cm of unhairing area. Taking tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm �� 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape. Opposite side skin is as blank. After closing 4 hours, dismantling, and go residual tested material with warm water cleaning, 1,24 and 48 hours after removing tested material are observed and are smeared position dermoreaction, and mark.

3, experimental result: any erythema does not occur in laboratory animal skin, red and swollen, inflammation phenomenon.

4, brief summary: judging according to skin wound repair standards of grading in " disinfection technology standard " (1999), animal skin stimulus intensity is belonged to nonirritant by ointment of the present invention.

Embodiment 3: vaginal mucomembranous irritant test result

1. test method:

Laboratory animal is selected 18 above-mentioned healthy rabbits, is randomly divided into three groups, often organize each 6, be respectively as follows: blank, excipient control, facial film of the present invention after quarantining 3 days. It is placed in excipient control group and tested material treated animal intravaginal with appropriately sized sterilizing cotton sliver leaching with sterile saline and tested material respectively, contacts with vaginal mucosa 6 hours, after 24 hours, put to death animal. Taking-up topical vaginal tissue, observes pathological changes situation.

2, result of the test: vaginal mucomembranous irritant test result

Embodiment 4: skin anaphylactic test result

Using facial film of the present invention, carry out inducing and exciting contact test, viewing test mice after 24 hours and 48 hours, all loseing skin has the phenomenon such as erythema and edema, with negative control group zero difference. It is shown that dermoreaction intensity is bordering on zero by this unguentum, namely without skin allergic reaction.

Embodiment 5: long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often group 15. In guinea pig back spinal column both sides, depilatory is uniformly coated with so that it is depilation scope about 40 square centimeters. Clean depilatory, often organize Cavia porcellus after observing 24 hours and be coated with eye cream 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observing the ordinary circumstance of Cavia porcellus, experiment is put to death animal after terminating and is carried out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range. Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes. Prompting, local skin and whole body important organ are showed no obvious toxic action by face mask of traditional Chinese medicine long-term prescription of the present invention.

Pharmacological experiment

One, the microcirculation experimental technique of the present invention:

1, materials and methods: take 50 mices, be randomly divided into 5 groups, often 10 (male and female half and half) of group, it is a little that matched group every Mus auris dextra is coated with normal saline; Positive controls every Mus auris dextra gives commercially available herborist Firm and preserves youthful looks mask (Shanghai herborist cosmetics company limited product), and tested group is external facial film of the present invention. 15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g subsequently, observes mouse right ear fine motion vein bore (��m) immediately and 0.2mm2 blood capillary net number .t inspection processes experimental data.

2 results and discussion

2.1. on microcirculatory impact

Compared with matched group, mice capillary open number is had showed increased (P < 0.01) by tested group 1; Tested group 2 venule bore and capillary open number are dramatically increased (P < 0.01); Mice fine motion, vein bore and capillary open number all had increase (P < 0.01) by tested group 3; Illustrate to be subject to reagent can improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).

The impact on mice fine motion, vein bore and capillary open number of table 1, beauty cream of the present invention

Two, the impact on Oleum Tiglii induced mice auricle edema

Take healthy mice 30, it is randomly divided into 3 groups, i.e. blank group, herborist Firm is preserved youthful looks mask matched group, facial film of the present invention, often group 10, male and female half and half, positive controls and instant component are not smeared, blank group smears isodose normal saline, successive administration 7 days, it is administered latter 0.5 hour in last, survey outside the left in ear of mice and be coated with Oleum Tiglii proinflammatory agent (2% Oleum Tiglii, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.1ml causes inflammation, cause inflammation and lay a left side with card punch (aperture 6mm) in latter 4 hours, auris dextra sheet, weigh, using left and right auricle weight difference as swelling degree, result is in Table 2.

The table 2 impact (X �� SD) on Oleum Tiglii induced mice auricle edema

Group	Number of animals (only)	Swelling (mg)
			Blank group	10	8.51��1.72
Herborist Firm is preserved youthful looks mask	10	5.38��1.52**
			Beauty mask of the present invention	10	4.45��1.32#

Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; By upper table experimental result it can be seen that the present invention has better detumescence smoothing wrinkle pharmacological action.

Three. the impact of rat paw edema caused by Carrageenan

Take healthy rat 30, body weight 180-220g, be randomly divided into blank group, mask matched group preserved youthful looks by herborist Firm, facial film of the present invention. Often group 10, male and female half and half, sub-cage rearing. Positive controls and drug component of the present invention smear 0.2g other every day, blank group gives the normal saline of same dosage and smears, successive administration 7 days, it is administered latter 30 minutes in last, inflammation is only caused respectively at Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/, before causing inflammation and cause the girth that 15,30,60,120,240 minutes survey the Rat Right metapedes sole of the foot after inflammation, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching front foot sole of the foot girth)/cause scorching front foot sole of the foot girth �� 100%]; Result is in Table 3.

The impact (X �� SD) of rat paw edema caused by table 3 on Carrageenan

Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; By upper table experimental result it can be seen that medicine group of the present invention has better crease-resistant flat muscle, eliminate the pharmacological action of skin pattern.

3 discuss

Clinical trial

Illustrate: my institute, in June ,-2015 in June, 2014, uses self-made face pack, to facial wrinkles, Neck wrinkles, canthus wrinkle, and evident in efficacy, existing report is as follows.

Clinical data: clinic chooses facial wrinkles, canthus wrinkle, Neck wrinkles obvious person 50 example. It is all women. Age 35-55 year, average 41.3 years old; Unmarried 25 example, the married 36 example, do not educate person 33 example; The course of disease 6 months-20 years, average 9.58 years; Educational level University Culture 27 people, white collar, teacher, cadre, office staff 38 example, other staff 12 example. Readme often stay up late overtime work 24 examples, 16 examples of having a sleepless night, daily maintenance skin person 42 people, laser therapy wrinkle removal 12 people. Clinic is divided into treatment group 25 example, matched group 25 example.

Therapeutic Method: treatment group adopts homemade traditional Chinese drug beauty cream, Fang Yong: Herba Centellae 30g, Rhizoma Polygonati Odorati 12g, Radix Angelicae Sinensis 11g, Herba Leonuri 11g, Rhizoma Chuanxiong 12g, Radix Salviae Miltiorrhizae 13g, Semen Persicae 11g, Radix Ginseng 12g, Flos Carthami 12g, Margarita 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 11g, Faeces Passeris 12g, pyracantha fortuneana 12g, Radix Ampelopsis 13g, Radix Angelicae Dahuricae 11g, Bombyx Batryticatus 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Et Rhizoma Nardostachyos 12g, Flos Inulae 12g, Flos Pelargonii 13g. Facial film is prepared into by the method for embodiment 2. Taking matched group, often organize 25 examples, use commercially available herborist Firm to preserve youthful looks mask respectively, every day one pastes.

Operating process: when carrying out in the flat bed of personnel, with 3% hydrogen peroxide cleaning face, with negative ion atomizer spraying face, coordinate meridian point massage 12 methods to carry out facial massage simultaneously, near the eyes local do emphasis massage, the time be about 10min. after take eye cream, be uniformly applied to face, note not doing into eyes, can suitably massage 10-15 minute. Once a day, 15 days courses for the treatment of. After terminating the course for the treatment of, monthly follow up a case by regular visits to 1 time, follow up a case by regular visits to continuously 3 months. Advise patient to eat less during treatment pungent, take a good rest, and disable other beauty care items.

Criterion of therapeutical effect

Effective: after treating for 2 courses for the treatment of, facial skin is compacted, face wrinkles, eye pouch, canthus wrinkle are substantially desalinated, and curative effect maintains more than 1 month, and facial skin is slightly improved and compacted, and eyestrain is alleviated; Take a turn for the better: eye pouch, canthus wrinkle are substantially thin out, disappear more than 50%, the conscious satisfaction of patient, and sleep quality is good; Or eye pouch disappears during treatment, but it is bad to follow up a case by regular visits to middle sleep, and overtime work has again recurrence; Invalid: eye pouch, canthus wrinkle change inconspicuous or unchanged; Or once disappeared more than 50%, but substantially increase the weight of in following up a case by regular visits to, testing crew is unsatisfied with.

Therapeutic outcome: treatment group total effective rate compares with each matched group, difference all has significance (P < 0.01), illustrates that self-control beauty cream curative effect is substantially better than the commercially available anti-wrinkle product that compacts. Refer to table 1

13 groups of Comparison of therapeutic tables (%) of table

Note: compare * P < 0.01 with other each group

Follow-up results follows up a case by regular visits to discovery, and massage person is better than the personage not massaged. After recurrence, if being continuing with still effective. Herba Centellae has a heat-clearing and toxic substances removing, inducing diuresis and reducing edema, nourishing, antiinflammatory, quelling effect. Deep skin cell can be stimulated to substitute. Herba Centellae can be compacted epidermis and corium coupling part, skin can be made to limber up, contribute to solving cutis laxa phenomenon, make skin smooth flexible; Promoting that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, and makes skin reach smooth effect of compacting. Also assist in impaired organization healing and consolidation skin. Being closely connected between epidermis with corium can be promoted, the increase of adipose cell can be suppressed again, it is prevented that hydroderma, appearance obesity.

Claims (10)

1. the Herba Centellae face mask of traditional Chinese medicine of a crease-resistant Firm, it is characterized in that, described face mask of traditional Chinese medicine includes the crude drug of following parts by weight: Herba Centellae 10��50 parts, Rhizoma Polygonati Odorati 10��20 parts, Radix Angelicae Sinensis 10��20 parts, Herba Leonuri 10��20 parts, Rhizoma Chuanxiong 10��20 parts, Radix Salviae Miltiorrhizae 10��20 parts, 10��20 parts of Semen Persicae, Radix Ginseng 10��20 parts, 10��20 parts of Flos Carthami, Margarita 10��20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Faeces Passeris 10��20 parts, pyracantha fortuneana 10��20 parts, Radix Ampelopsis 10��20 parts, the Radix Angelicae Dahuricae 10��20 parts, Bombyx Batryticatus 10��20 parts, the Rhizoma Atractylodis Macrocephalae 10��20 parts, Radix Et Rhizoma Nardostachyos 10��20 parts, Flos Inulae 10��20 parts, Flos Pelargonii 10��20 parts.

2. the Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm according to claim 1, it is characterized in that, described face mask of traditional Chinese medicine includes the crude drug of following parts by weight: Herba Centellae 10��30 parts, Rhizoma Polygonati Odorati 10��15 parts, Radix Angelicae Sinensis 10��15 parts, Herba Leonuri 10��15 parts, Rhizoma Chuanxiong 10��15 parts, Radix Salviae Miltiorrhizae 10��15 parts, 10��15 parts of Semen Persicae, Radix Ginseng 10��15 parts, 10��15 parts of Flos Carthami, Margarita 10��15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Faeces Passeris 10��20 parts, pyracantha fortuneana 10��20 parts, Radix Ampelopsis 10��20 parts, the Radix Angelicae Dahuricae 10��20 parts, Bombyx Batryticatus 10��20 parts, the Rhizoma Atractylodis Macrocephalae 10��20 parts, Radix Et Rhizoma Nardostachyos 10��20 parts, Flos Inulae 10��20 parts, Flos Pelargonii 10��20 parts.

3. the Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm according to claim 1, it is characterized in that, described face mask of traditional Chinese medicine includes the crude drug of following parts by weight: Herba Centellae 10��40 parts, Rhizoma Polygonati Odorati 10��20 parts, Radix Angelicae Sinensis 10��20 parts, Herba Leonuri 10��20 parts, Rhizoma Chuanxiong 10��20 parts, Radix Salviae Miltiorrhizae 10��20 parts, 10��20 parts of Semen Persicae, Radix Ginseng 10��20 parts, 10��20 parts of Flos Carthami, Margarita 10��20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Faeces Passeris 10��15 parts, pyracantha fortuneana 10��15 parts, Radix Ampelopsis 10��15 parts, the Radix Angelicae Dahuricae 10��15 parts, Bombyx Batryticatus 10��15 parts, the Rhizoma Atractylodis Macrocephalae 10��15 parts, Radix Et Rhizoma Nardostachyos 10��15 parts, Flos Inulae 10��15 parts, Flos Pelargonii 10��15 parts.

4. the preparation method of the Herba Centellae face mask of traditional Chinese medicine of a crease-resistant Firm as according to any one of claims 1 to 3, it is characterised in that described preparation method comprises the following steps:

A. the preparation of Herba Centellae, extracts, as component 1;

B. take Radix Et Rhizoma Nardostachyos, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 2;

C. all the other crude drug are removed Margarita external ethanol extraction 2 times, merge concentrated extracting solution, as component 3;

D., the Margarita that component 1, component 2 add after mixing with component 3 pulverizing is in harmonious proportion with Cera Flava, and sterilize tinning.

5. the preparation method of the Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm according to claim 4, it is characterised in that in described step a, takes the Herba Centellae chopping will plucked spring and summer, crosses 80-100 mesh sieve.

6. the preparation method of the Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm according to claim 4, it is characterized in that, in described step a, farther include the step extracted, medicated powder has been placed in lid stainless steel cask, has added 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, make abundant expansion; Drug sample after moistening expansion is mixed after paving pine by filter plate gauze bag parcel again bottom percolator do to dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, 2/3 eminence that must not exceed percolator loaded by medicated powder; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow 2��3ml per minute, filtrate puts into liquid container, and ethanol during by emptying pours liquid container into; Percolate is merged and stands. Heating is concentrated into paste, stand for standby use, becomes component 1.

7. the preparation method of the Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm according to claim 4, it is characterised in that in described step b, take Radix Et Rhizoma Nardostachyos, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverized 120-150 order dusting cover stand-by, as component 2.

8. the preparation method of the Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm according to claim 4, it is characterized in that, in described step c, all the other raw materials described are added soak with ethanol 4-6 hour that accounts for its quality 5-10 times amount except Margarita, heating extraction 2 times, each 1-2 hour, united extraction liquid, supernatant is removed after standing, then 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, standing is put in economic benefits and social benefits vacuum concentrator and is mixed, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, insert 0��5 DEG C of deepfreeze again 24 hours, the filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, as component 3.

9. the preparation method of the Herba Centellae face mask of traditional Chinese medicine of crease-resistant Firm according to claim 4, it is characterized in that, in described step d, first blending ingredients 1, component 2 stir with component 3,120-150 order dusting cover will be crossed again after crushing pearl, pouring into and wherein stir, add Cera Flava and make facial film, ultraviolet sterilization is bottled.

10. the using method of the Herba Centellae face mask of traditional Chinese medicine of a crease-resistant Firm according to any one of claim 1��9, it is characterized in that, the using method of facial film is, after each face cleaning just before going to bed, by facial film uniform application in face, and by middle finger finger belly face message 15-20 minute, after fully absorbing to it, wash away after half an hour, can use 3-4 time weekly.