CN104173812A - Pharmaceutical composition for treating blood-heat bleeding type acute idiopathic thrombocytopenic purpura and preparation method of pharmaceutical composition - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating blood-heat bleeding type acute idiopathic thrombocytopenic purpura and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises the following raw herba materials: herba andrographitis, folium isatidis, patience dock root, hyrtanandra hirta, trollflower, rulvis glycyrrhizae extractionis sedilis, houttuynia cordata, humifuse euphorbia herb, potentilla chinensis, Chinese holly, dried rehamnnia root, umbilicaria esculenta, portulaca oleracea, flos sophorae, senna, aloe, fructus cannabis, hypericum ascyron, pollen typhae, garden burnet, lalang grass rhizome, ramie root, rumex japonicus, callicarpa bodinieri, vitis bryoniifolia, radix ophiopogonis and polygonatum odoratum. The pharmaceutical composition has the beneficial effects that that the pharmaceutical composition has the advantages of rapidness to take effect, definite curative effect, high security, no toxic or side effect and low possibility of replase when being used for treating blood-heat bleeding type acute idiopathic thrombocytopenic purpura based on the traditional Chinese medicine principles and the treatment principles that heat and toxic material clearing away and blood cooling and bleeding stopping are highlighted and qi and spleen tonifying is secondarily emphasized.

Description

Be used for the treatment of pharmaceutical composition of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura and preparation method thereof

 

Technical field

The present invention relates to contain the medicine that derives from plant, animal or raw mineral materials, particularly a kind of pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura and preparation method thereof.

 

Background technology

Idiopathic thrombocytopenic purpura (ITP), or title idiopathic thrombocytopenic purpura, refer to the thrombocytopenia causing without the obvious exogenous cause of disease, but great majority are because the platelet destruction that immunoreation causes increases, therefore have another name called autoimmunity thrombocytopenia, are the comparatively common hemorrhagic hematopathys of a class, its feature is that platelet life span shortens, bone marrow megakaryocyte increases, and the serum of 80%-90% case or platelet surface have IgG antibody, and spleen is without obvious enlargement.According to pathogeny, risk factor and the course of disease, ITP is divided into acute and chronic type two classes.Child 80% is acute (AITP), asexuality difference, two season of winter in spring susceptible disease, once source of disease is removed, disease was fully recovered in the 6-12 month, and adult ITP95% is chronic type (CITP) above, men and women's the about 1:3 of ratio, it is generally acknowledged the one that belongs to autoimmune disease, delay is difficult.Primary disease case fatality rate is about 1%, and majority is because of intracranial hemorrhage death, and ITP main clinical manifestation is mucocutaneous hemorrhage or visceral hemorrhage.

Etiology and pathology: 1, acute ITP mostly occurred in the convalescent period of viral infection or upper respiratory tract infection, as rubella, measles, chickenpox, carcinoma of parotid gland etc., in patients serum, there is higher antiviral antibody, platelet surface associated antibodies obviously increases, therefore think what virus antigen caused, pathogeny may be that autoantibody and the platelet membrane that antigen antibody complex including virus antigen and platelet fc receptor or virus antigen produce plays cross reaction, damage platelet, and removed by phagocyte.2, chronic ITP premorbid often infects history without forerunner, because platelet structural antigens changes due to the autoantibody causing, 80%～90% case history has platelet surface associated antibodies, wherein 95% is PalgG, 2/3 is PalgG and PalgM, minority act as PalgA and pac, antibody directly acts on the glycoprotein on platelet membrane, minority effect and Gbib complex, platelet life span is shortened and changing function, its content and platelet life span are negative correlation, have confirmed that spleen is the main place that platelet antibody produces.

Clinical manifestation has the following aspects:

(1) symptom

1, acute: be common in child, account for 90% of immunity thrombocytopenia case history, men and women's sickness rate is close, first 1～3 week 84% patient of onset has respiratory tract or other virus infection history, therefore at most, onset is rapid, can have heating in morbidity autumn and winter, fear of cold, mucocutaneous purpura, as patient's headache, vomiting, watch out for the possibility of intracranial hemorrhage, the course of disease mostly is self limiting, more than 80% can spontaneous remission, and average course of disease 4～6 weeks, minority can delay or the several years transfer to above chronic, acute account for adult ITP less than 10%.

2, chronic type: be common in young women, women is male 3～4 times, onset concealment; symptom is lighter, hemorrhage Chang Fanfu outbreak, and each hemorrhage lasting a couple of days is to the several months; extent of hemorrhage is relevant with platelet count, and platelet >50 × 109/L is normal for hemorrhage after damage; Platelet can have hematostaxis in various degree between (10～50) × 109/L, and platelet is less than 10 × 109/L often severe haemorrhage, and patient's systemic conditions except bleeding is good.

(2) sign

1, acute: extensive and serious mucocutaneous purpura can occur suddenly, even large stretch of ecchymosis and hematoma, skin petechia mostly is general, taking lower limb as many, be evenly distributed, the hemorrhage nose of being more common in, gums, can there be bleeding blister in oral cavity, gastrointestinal tract and urinary tract are hemorrhage much, intracranial hemorrhage is rare, but there is no what danger, often not enlargement of spleen.

2, chronic type: skin purpura is common with Lower Distal Extremities, can have the hemorrhage nose of being more common in, gums, oral mucosa is hemorrhage, and women's menorrhagia is unique symptom sometimes, and outbreak can cause anemia and slight splenomegaly repeatedly, if any obvious splenomegaly, Secondary cases platelet probability except.

Chinese medicine thinks, idiopathic thrombocytopenic purpura belongs to the categories such as motherland's medical science " blood disorder ".Allly causes burning hot smoked burning or deficient QI failing to control by many reasons, cause blood circulating away from normal passage, or overflow is in all keys of mouth and nose, or under let out in front and back two the moon, or ooze out the illness forming in skin, be referred to as blood disorder.That is to say, the hemorrhagic illness of non-physiologic, is called blood disorder.Cure in ancient times in nationality, be also called disorders of blood or lose blood.In the time that a variety of causes causes venation damage or abnormal circulation of blood, will cause that blood from overflowing arteries and veins forms blood disorder outward.Say as " Sanyin Ji Yi Bingzheng Fang Lun is lost blood and chatted opinion ": " husband's blood still water also, water by ground row, all manage in hundred rivers, without stop up determine anxiety.The circumfluence of blood is in person honor, warp, mansion, Yu, outward not by four gas are hindered, inside not by seven emotions are strongly fragrant, naturally pleasantly.Just in case micro-refreshing joint a surname, must cause to stop up and close, thus blood must not follow through multiple abscess, flourish hundred arteries and veins of supporting, or tears or loose, or lower and die anti-, or contrary and overflow, just be tell, be defeated in battle,, profit, antiperspirant, all card lifes of expectorant here." distinguish that its clinical syndrome is divided into: bleeding due to blood-heat, hyperactivity of fire caused by deficiency of YIN and QI failing to control blood, wherein bleeding due to blood-heat type symptom is: livid purple speckle or speckle appear in skin, or with epistaxis, bleeding from the gum, have blood in stool, hematuria; or have heating, thirsty, constipation; red tongue, yellow fur, the dizzy number of arteries and veins.

At present, the medication of western medical treatment idiopathic thrombocytopenic purpura is as adrenocortical hormone, immunoglobulin etc.But western medical treatment idiopathic thrombocytopenic purpura prolonged application hormones class adverse effect is more, easily produces dependency, drug resistance etc.Chinese medicine has system and distinctive theoretic knowledge to blood disorder, not only can make up the deficiency of doctor trained in Western medicine, also possess unique advantage and feature: utilize Traditional Chinese medical theory, from normal generation and the operation of integrally-regulated body qi-blood-body fluid, then determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, specific aim is stronger, the drug effect focus of going directly, the course for the treatment of is shorter, safe and effective, patient's quality of life etc. can be obviously improved, clinical marketing can be carried out.

 

Summary of the invention

Technical problem to be solved by this invention is, a kind of pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura and preparation method thereof is provided, this pharmaceutical composition is taking heat-clearing and toxic substances removing, cooling blood for hemostasis as main, QI invigorating spleen reinforcing is auxiliary Therapeutic Principle, that treatment bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura has is rapid-action, determined curative effect, safe, have no side effect and be difficult for the advantage recurring.

In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura, wherein, comprise following raw medicinal material: Herba Andrographis, Folium Isatidis, Radix Rumicis Patientiae, Herba Gonostegiae hirtae, Flos Trollii, Preparatum Glycyrrhizae, Herba Houttuyniae, Herba Euphorbiae Humifusae, Herba Potentillae Chinensis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rehmanniae, Umbillcaria esculenta, Herba Portulacae, Flos Sophorae, Herba Cassiae Mimosoidis, Aloe, Fructus Cannabis, Herba Hyperici, Pollen Typhae, Radix Sanguisorbae, Rhizoma Imperatae, Radix Boehmeriae, Radix Rumicis Japonici, Folium Callicarpae Formosanae, Caulis et folium vitis thunbergii, Radix Ophiopogonis and Rhizoma Polygonati Odorati.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Andrographis 11-18 weight portion, Folium Isatidis 12-18 weight portion, Radix Rumicis Patientiae 15-20 weight portion, Herba Gonostegiae hirtae 12-17 weight portion, Flos Trollii 5-11 weight portion, Preparatum Glycyrrhizae 7-16 weight portion, Herba Houttuyniae 6-17 weight portion, Herba Euphorbiae Humifusae 10-15 weight portion, Herba Potentillae Chinensis 12-17 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 12-17 weight portion, Radix Rehmanniae 10-20 weight portion, Umbillcaria esculenta 8-14 weight portion, Herba Portulacae 8-18 weight portion, Flos Sophorae 5-12 weight portion, Herba Cassiae Mimosoidis 6-17 weight portion, Aloe 8-12 weight portion, Fructus Cannabis 4-9 weight portion, Herba Hyperici 9-17 weight portion, Pollen Typhae 5-12 weight portion, Radix Sanguisorbae 2-7 weight portion, Rhizoma Imperatae 7-15 weight portion, Radix Boehmeriae 5-9 weight portion, Radix Rumicis Japonici 10-16 weight portion, Folium Callicarpae Formosanae 5-11 weight portion, Caulis et folium vitis thunbergii 6-16 weight portion, Radix Ophiopogonis 10-20 weight portion and Rhizoma Polygonati Odorati 9-16 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Herba Andrographis 14 weight portions, Folium Isatidis 15 weight portions, Radix Rumicis Patientiae 17 weight portions, Herba Gonostegiae hirtae 14 weight portions, Flos Trollii 7 weight portions, Preparatum Glycyrrhizae's 11 weight portions, Herba Houttuyniae 11 weight portions, Herba Euphorbiae Humifusae 12 weight portions, Herba Potentillae Chinensis 16 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 14 weight portions, Radix Rehmanniae 15 weight portions, Umbillcaria esculenta 11 weight portions, Herba Portulacae 14 weight portions, Flos Sophorae 8 weight portions, Herba Cassiae Mimosoidis 11 weight portions, Aloe 10 weight portions, Fructus Cannabis 7 weight portions, Herba Hyperici 13 weight portions, Pollen Typhae 8 weight portions, Radix Sanguisorbae 6 weight portions, Rhizoma Imperatae 9 weight portions, Radix Boehmeriae 7 weight portions, Radix Rumicis Japonici 13 weight portions, Folium Callicarpae Formosanae 7 weight portions, Caulis et folium vitis thunbergii 9 weight portions, Radix Ophiopogonis 15 weight portion and Rhizoma Polygonati Odorati 13 weight portions.

Described pharmaceutical composition also comprises the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Cirrhifolii, Glycine max (L.) Merr., Herba Pimpinellae thellungianae and Poria, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Andrographis 11-18 weight portion, Folium Isatidis 12-18 weight portion, Radix Rumicis Patientiae 15-20 weight portion, Herba Gonostegiae hirtae 12-17 weight portion, Flos Trollii 5-11 weight portion, Preparatum Glycyrrhizae 7-16 weight portion, Herba Houttuyniae 6-17 weight portion, Herba Euphorbiae Humifusae 10-15 weight portion, Herba Potentillae Chinensis 12-17 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 12-17 weight portion, Radix Rehmanniae 10-20 weight portion, Umbillcaria esculenta 8-14 weight portion, Herba Portulacae 8-18 weight portion, Flos Sophorae 5-12 weight portion, Herba Cassiae Mimosoidis 6-17 weight portion, Aloe 8-12 weight portion, Fructus Cannabis 4-9 weight portion, Herba Hyperici 9-17 weight portion, Pollen Typhae 5-12 weight portion, Radix Sanguisorbae 2-7 weight portion, Rhizoma Imperatae 7-15 weight portion, Radix Boehmeriae 5-9 weight portion, Radix Rumicis Japonici 10-16 weight portion, Folium Callicarpae Formosanae 5-11 weight portion, Caulis et folium vitis thunbergii 6-16 weight portion, Radix Ophiopogonis 10-20 weight portion, Rhizoma Polygonati Odorati 9-16 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Rhizoma Polygonati Cirrhifolii 13-17 weight portion, Glycine max (L.) Merr. 5-12 weight portion, Herba Pimpinellae thellungianae 8-15 weight portion and Poria 10-18 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Andrographis 13 weight portions, Folium Isatidis 16 weight portions, Radix Rumicis Patientiae 17 weight portions, Herba Gonostegiae hirtae 14 weight portions, Flos Trollii 6 weight portions, Preparatum Glycyrrhizae's 9 weight portions, Herba Houttuyniae 11 weight portions, Herba Euphorbiae Humifusae 12 weight portions, Herba Potentillae Chinensis 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 14 weight portions, Radix Rehmanniae 15 weight portions, Umbillcaria esculenta 11 weight portions, Herba Portulacae 12 weight portions, Flos Sophorae 7 weight portions, Herba Cassiae Mimosoidis 11 weight portions, Aloe 9 weight portions, Fructus Cannabis 6 weight portions, Herba Hyperici 13 weight portions, Pollen Typhae 8 weight portions, Radix Sanguisorbae 4 weight portions, Rhizoma Imperatae 11 weight portions, Radix Boehmeriae 6 weight portions, Radix Rumicis Japonici 14 weight portions, Folium Callicarpae Formosanae 9 weight portions, Caulis et folium vitis thunbergii 10 weight portions, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 13 weight portions, the Rhizoma Atractylodis Macrocephalae 16 weight portions, Rhizoma Polygonati Cirrhifolii 14 weight portions, Glycine max (L.) Merr. 7 weight portions, Herba Pimpinellae thellungianae 11 weight portions and Poria 14 weight portions.

In order better to realize foregoing invention object, the present invention also provides a kind of pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura, and the dosage form of described pharmaceutical composition is capsule, and its preparation method is:

The first step, is mixed in proportion each raw medicinal material in described pharmaceutical composition, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, successively adds Pulvis Talci, magnesium stearate in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5:0.15～0.5, and described capsule 's content is incapsulated in housing, obtain capsule finished product.

The dosage form of described pharmaceutical composition is tablet, and its preparation method is:

The first step, is mixed in proportion each raw medicinal material in described pharmaceutical composition, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

The invention has the beneficial effects as follows: pharmaceutical composition of the present invention, utilize the traditional theory of Chinese medical science of China, taking heat-clearing and toxic substances removing, cooling blood for hemostasis as main, QI invigorating spleen reinforcing is auxiliary Therapeutic Principle, that treatment bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura has is rapid-action, determined curative effect, safe, have no side effect and be difficult for the advantage recurring.

 

Detailed description of the invention

Blood from overflowing is between skin, and the disease of the livid purple speckle of cutaneous manifestations or speckle, is called purpura.Also there are the hematohidrosis of being called and hemorrhagic disease with purpura person.As " Yizong Jinjian is lost blood blanket " said: " hematohidrosis is said in dermatorrhagia." " Elementary Medicine macule " say: " and internal injury is sent out speckle, light as mosquito mark measles person, how brothers, from the beginning of no headache fever of the body, be insufficiency of stomach fire swim in outside." " Waike Zhengzong, Orthodox Manual of External Diseases hemorrhagic disease with purpura " say: " and experience abnormal climates in four seasons, strongly fragrant loose in skin, form big or small livid purple speckle, if color Fructus Vitis viniferae is sent out all over body women's head-ornaments ... evil poison passes stomach, dental root hemorrhage, and empty people for a long time, speckle gradually just moves back." and children's's the spleen tending to insufficiency usually, be also injury due to diet, therefore answer invigorating the spleen and stomach while treatment, improve curative effect.The invention provides a kind of pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura, with heat-clearing and toxic substances removing, cooling blood for hemostasis is main, QI invigorating spleen reinforcing is auxiliary Therapeutic Principle, select prescription: Herba Andrographis, Folium Isatidis, Radix Rumicis Patientiae, Herba Gonostegiae hirtae, Flos Trollii, Preparatum Glycyrrhizae, Herba Houttuyniae, Herba Euphorbiae Humifusae, Herba Potentillae Chinensis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rehmanniae, Umbillcaria esculenta, Herba Portulacae, Flos Sophorae, Herba Cassiae Mimosoidis, Aloe, Fructus Cannabis, Herba Hyperici, Pollen Typhae, Radix Sanguisorbae, Rhizoma Imperatae, Radix Boehmeriae, Radix Rumicis Japonici, Folium Callicarpae Formosanae, Caulis et folium vitis thunbergii, Radix Ophiopogonis and Rhizoma Polygonati Odorati, preferably also comprise the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Cirrhifolii, Glycine max (L.) Merr., Herba Pimpinellae thellungianae and Poria.Wherein, Herba Andrographis, Folium Isatidis, Radix Rumicis Patientiae, Herba Gonostegiae hirtae, Flos Trollii, Preparatum Glycyrrhizae, Herba Houttuyniae, Herba Euphorbiae Humifusae, Herba Potentillae Chinensis, Ilex purpurea Hassk.[I.chinensis Sims have effect of heat-clearing and toxic substances removing; Radix Rehmanniae, Umbillcaria esculenta, Herba Portulacae, heat clearing away sophora removing heat from blood; Herba Cassiae Mimosoidis, Aloe, Fructus Cannabis relieving constipation by purgation; Under Herba Hyperici, Pollen Typhae, Radix Sanguisorbae, Rhizoma Imperatae, Radix Boehmeriae, Radix Rumicis Japonici, Folium Callicarpae Formosanae, Caulis et folium vitis thunbergii clearing away heat and cooling blood stop blooding, rush down; Radix Ophiopogonis, Rhizoma Polygonati Odorati YIN nourishing and the production of body fluid promoting; The Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Cirrhifolii, Glycine max (L.) Merr., Herba Pimpinellae thellungianae and Poria have effect of QI invigorating spleen reinforcing.

Wherein, the pharmacological property of above-mentioned each raw medicinal material is as follows:

Herba Andrographis: have heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can be treated furuncle toxic swelling, trauma infection contamination etc.Herba Andrographis has eliminating inflammation and expelling toxin effect, once be applied to clinically multi-infection disease, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.Preparation and usage: make injection punishment, oral capsule or tablet, consumption must look various places produce the different content of preparation and different.To general inflammation infection, can 2～3 money decoctions of Herba Andrographis Radix Glycyrrhizae, 1 dose of every day; Or tablet (every suitable crude drug in whole 1 gram) is for oral administration, each 4～8, every day 3～4 times.To cutization pyogenic infection wound surface, available Folium Andrographis is ground into powder, makes 1:4 aqueous solution, soaks gauze external application wound.Suppurative otitis media be can be made into ear drop topical application, simultaneously Tabellae Andrographitis for oral administration.

Folium Isatidis: hardship, cold; Enter liver, the heart, stomach warp.Compendium of Material Medica: " main pyrotoxic dysentery, jaundice, sore throat, erysipelas." " LANYE juice, separates Mylabris, Yuan green grass or young crops, tree of heaven chicken, Cinnabaris, arsenicum sablimatum poison." " book on Chinese herbal medicine is just ": " controlled pestilence pyretic toxicity and goes mad, wind heat macule, and carbuncle and ulcer swells and ache, relieving thirst and restlessness, only epistaxis, haematemesis, kills infantile malnutrition erosion, incised wound curare.All with the heat malicious person that holds concurrently, all should LANYE smash juice and use it." heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Resisting pathogenic microbes effect: the in vitro tests of Folium Isatidis decoct has certain inhibitory action to staphylococcus aureus, alpha streptococcus, meningococcus, streptococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium; Folium Isatidis also has inhibitory action to encephalitis b virus, mumps virus, influenza virus etc. and Folium Isatidis is killed leptospiral effect in addition.

Radix Rumicis Patientiae: bitter, sour, cold.Function cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing, parasite killing.For dysfunctional uterine hemorrhage, spit blood, spitting of blood, epistaxis, gingival hemorrhage, tail, duodenal hemorrhage, have blood in stool, purpura, constipation, edema; Scabies is controlled in external, furuncle, seborrheic dermatitis.

Herba Gonostegiae hirtae: sweet; Micro-hardship; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Spleen invigorating removing food stagnancy; Inducing diuresis and reducing edema; Dissipating blood stasis hemostasis.Main acute mastitis; Toxic swelling; Dysentery; Dyspepsia; Abdominal pain due to retention of food; Glycoside is long-pending; Leukorrhagia; Edema; Dysuria; Dysmenorrhea; Traumatic injury; Hemoptysis; Spit blood; Traumatic hemorrhage.

Flos Trollii: hardship, cool.Function cures mainly: heat-clearing and toxic substances removing.For acute and chronic tonsillitis, acute otitis media, acute myringitis, acute conjunctivitis, acute lymphangitis.

Preparatum Glycyrrhizae: sweet, salty, cold.Return stomach warp.Function cures mainly: heat-clearing and toxic substances removing.Send out speckle for calentura, heat in blood poison is contained, macular eruption being dark-purple, or high heat goes mad, and the disease such as laryngopharynx swelling and pain, erysipelas.

Herba Houttuyniae: cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The function of inducing diuresis for treating stranguria syndrome.Cure mainly the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.The modern multiplex lung abscess of controlling, pneumonia, acute and chronic tracheitis, urinary tract infection etc.Modern pharmacology experiment shows, the effects such as that these product have is antibacterial, antiviral, raising immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, upper respiratory tract infection, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, pulmonary carcinoma, cervical erosion, suppurative arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitisshock, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurative otitis media, mumps, pimple shape urticaria, chronic pharyngitis, anorectal disease, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.

Herba Euphorbiae Humifusae: being the Herba Euphorbiae Humifusae of euphorbia plant, is a kind of Chinese crude drug, gathers at summer, Qiu Erji, removes impurity, dries." book on Chinese herbal medicine converges and says ": " removing pathogenic heat from blood and dissipating blood stasis, the medicine of removing toxic substances dysentery relieving also.Kind through-flow blood vessels, specially clear up skin infection.All disorders of blood and because of the hot envoy of institute, suitable with it.If non-heat in blood is disease, and the thin weak person of gastric qi, again when consideration row." Compendium of Material Medica: " main carbuncle malignant boil, it is hemorrhage that Jin Ren flutters damage, dysentery, hematochezia, metrorrhagia, the blood that can fall apart hemostasis, diuresis." can heat-clearing and toxic substances removing, dampness removing jaundice eliminating, promoting blood circulation and hemostasis.Main dysentery, have loose bowels, jaundice; Hemoptysis; Spit blood; Hematuria; Have blood in stool; Metrorrhagia; Agalactia; Treating swelling and pain by traumatic injury and pathopyretic ulcer etc.Heat in blood spit blood, epistaxis person, can with Radix Rehmanniae, the same use of Cortex Moutan, to increase the merit of cooling blood for hemostasis.Jaundice due to damp-heat, dysuria person, can be alone, or with the compatibility such as Herba Artemisiae Scopariae, Fructus Gardeniae, with heat-clearing and dampness-resolving, also can be used for carbuncle malignant boil, traumatic pain eczema ulcer, burn and scald and injure all cards of venom, clinical multiplex fresh goods is mashed external application.

Herba Potentillae Chinensis: bitter in the mouth, cold in nature, return liver, large intestine channel, has heat clearing and damp drying, the effect of eliminating pathogenic heat from blood to cure dysentery, for damp-heat dysentery, have loose bowels, the card such as dysentery, stomachache, acute bacterial are understood, heat in blood is hemorrhage, spit blood, have blood in stool, hematuria, metrorrhagia.The flat board method that burrows for agent, has inhibitory action to shigella and shigella flexneri before herb.Committee's mound Lay all has certain inhibitory action to dysentery bacterium, staphylococcus aureus, bacillus pyocyaneus, bacillus subtilis with ameba.Study its Antibacterial Constituents and be mainly gallic acid, Quercetin.Somebody finds that it has certain kill activity to trichomonas vaginitis.The isolated heart of this product to the frog, rabbit, rabbit in vitro and be all inhibitory action at body intestinal tube, is expansion to guinea pig in vitro bronchus, and its isolated uterine is played to excitation.

Ilex purpurea Hassk.[I.chinensis Sims: hardship, puckery, cool." Bencao Tujing ": " ashing, face cream is coated with it, controls chap chilblain special effect, the double scar defect that goes out." Ilex purpurea Hassk.[I.chinensis Sims controls cough due to lung-heat, laryngopharynx swelling and pain, pyretic stranguria, dysentery.This product bitter cold, is good at clearly purte the white and relieving heat toxin.Stop up cough, pharyngalgia and anemopyretic cold on lung-fire; Or invade under pyretic toxicity, the puckery pain of dribbling urination, dysentery person, alone this product imitates.The Ilex purpurea Hassk.[I.chinensis Sims heating that cures cold, cough due to lung-heat, laryngopharynx swelling and pain, the puckery pain of dribbling urination and dysentery, diarrhoea disease, can alone this product one or two, decoction; Also can coordinate Herba Taraxaci, Herba Cayatiae Japonicae, Commeline communis to be equal to use.This product has the effect of astringing to arrest bleeding.For traumatic hemorrhage, can smash deposited wound by alone fresh leaf; Also can use cured leaf porphyrize, spread and apply at wound, additional wrapping.Ilex purpurea Hassk.[I.chinensis Sims decoct is for oral administration can cause mild nausea and loss of appetite, injection intramuscular injection part can cause pain, quiet can cause pain and even phlebitis occurs, Ilex purpurea Hassk.[I.chinensis Sims coat early burn wound surface also can have continue 5～10 minutes one cross property pain, above-mentioned untoward reaction is all due to the volume tannin that contains of Ilex purpurea Hassk.[I.chinensis Sims.

Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding and fall, muscle absolutely, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, longue meat.Make soup and gather except cold and heat, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in treating the diseases such as hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.By by the Radix Rehmanniae taking Fructus Amomi, wine, Pericarpium Citri Reticulatae as adjuvant, repeatedly steam and shine to color blackening, quality softness is for Radix Rehmanniae Preparata, and the LIUWEI DIHUANG WAN that has Radix Rehmanniae Preparata to make, be exactly famous the kidney invigorating good medicine, the clinical treatment that is also usually used in the diseases such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.

Umbillcaria esculenta: sweet, flat.Function cures mainly: clearing away heat to stop bleeding, relieving cough and resolving phlegm.For spitting blood, epistaxis, metrorrhagia, cystitis, enteritis, dysentery, bronchitis.Venom is controlled in external, burn and scald.

Herba Portulacae: acid, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea; Furuncle swelling toxin is controlled in external, eczema, herpes zoster.

Flos Sophorae: hardship, is slightly cold.Return liver, large intestine channel.Function cures mainly: cooling blood for hemostasis, purging liver-fire.Be used for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spits blood, epistaxis, liver-heat conjunctival congestion, has a headache dizzy.

Herba Cassiae Mimosoidis: sweet, micro-hardship, flat.Function cures mainly: heat-clearing and toxic substances removing, diuresis, relieving constipation.For oedema due to nephritis, thirsty, cough with copious phlegm, habitual constipation, venom.

Aloe: hardship, cold.Return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.

Fructus Cannabis: sweet in the mouth, property is flat.Energy strengthening the spleen tonify deficiency, nourishing YIN to relieve dryness, relieving constipation.Containing protein, fatty oil, lecithin, glucuronic acid, sterol, calcium, magnesium, vitamin B1, B2, contain the compositions such as oleic acid, linoleic acid, linolenic acid and cannabinol in fatty oil.Swell and ache for beriberi; The empty senilism of body; Insufficiency of heart-YIN, palpitation and restlessness; Blood deficiency Tianjin wound, dryness of the intestine constipation etc.The Fructus Cannabis that shells contains protein 34.6%, fat 46.5%, and 11.6% carbohydrate.The most important characteristics of Fructus Cannabis is that it provides essential fatty acid (EFAs), α-linolenic acid necessary in human body meals simultaneously.The carbohydrate content of Fructus Cannabis of shelling is 11.5%, and its sugared content is 2%.Shell in the carbohydrate of Fructus Cannabis, have 6% to be to exist with the form of fiber.The fiber of Fructus Cannabis powder, containing being 40%, is the highest in the middle of all powder process class grain.Except containing the necessary various nutrients of the mankind, Fructus Cannabis food contain high-load with alpha-, beta-, gamma-, the antioxidant (92.1 mg/ 100g) of and delta-tocopherol and alpha-tocotrienol form.In addition, Fructus Cannabis contains other vitamin and the mineral that kind is very wide.

Herba Hyperici: hardship, cold.Function cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing.For spitting blood, spitting of blood, epistaxis, metrorrhagia, jaundice, hepatitis; Wound hemorrhage is controlled in external, burn and scald, eczema, impetigo.

Pollen Typhae: sweet, flat.Return liver, pericardium channel.Function cures mainly: hemostasis, and blood stasis dispelling, treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.

Radix Sanguisorbae: picric acid, cold, nontoxic; Return liver, lung, kidney, large intestine channel." book on Chinese herbal medicine is looked for the truth ": " Radix Sanguisorbae, all books are all sayed because of its bitter cold, can enter part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system heat extraction, know from lower solution in order to do heat.Yan Xingchen is and puckery again, and ordinary person's disease suffering from told the diseases such as nosebleed metrorrhagia hemorrhoidal hamorrhage dysentery, obtains this and can not understand by puckery blood.By this, not without not tally, Ju knows that its heat do not remove, and blood is more than, and its heat is both clear, and blood is from peace, and the main convergence of its property, can fall clearly, again can astringent therapy, do not consider clearly it and cross and let out, puckery also do not consider itself or stagnant, the antipyretic hemorrhage of strength is also." " herbal classic ": " and housewife people's seven kinds of impairments, leukorrheal diseases, pain relieving, except disliking meat, hidroschesis, treats incised wound." function cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.For spitting blood, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.

Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel." Bencao Tujing ": " Rhizoma Imperatae, the present has it everywhere.Spring sprouts, and cloth ground is as pin, and the thatch pin of calling between custom, also can eat, very beneficial children's.Xia Sheng spends in vain, and fine so to the autumn, and withered, its root is extremely pure white, also very sweet and refreshing, adopts root June and uses." Compendium of Material Medica: " emesis all blood of being defeated in battle, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication." have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, being mainly used in lung stomach has haematemesis, the hemoptysis of accumulated heat, and damp invasion of lower energizer pents up the hematuria of bladder, calentura excessive thirst taking fluids profusely, gastropyretic vomiting, the cards such as jaundice due to damp-heat.Rhizoma Imperatae decoct and water logging agent gavage, and normal rabbits is had to diuresis, administration 5-10 days, and diuresis is the most obvious.Rhizoma Imperatae decoct has obvious inhibitory action to Fu Shi and sonne bacillus in vitro, but to will Hayes and the effect of easypro Shigella flexneri nothing.Contraction and the metabolism of the contained Coixol of Rhizoma Imperatae to skeletal muscle has inhibitory action.

Radix Boehmeriae: sweet in the mouth is sliding, cold, nontoxic; Enter lung, spleen channel." Japan hanako materia medica ": " control heart heat of the diaphragm, leak tire hematochezia, antenatal rear vexed vexed, day hot disease of row, the large Kuang ， of extreme thirst An poisoned arrow, snakeworm sting." essentials of Matea Medica: " and nourishing YIN, removing blood stasis with potent drugs, antipyretic, moisturize.Control carbuncle, carbuncle on the back, incised wound, injured, chicken, fishbone are choked." function heat clearing away, hemostasis, removing toxic substances, dissipating blood stasis.Control calentura extreme thirst, mad greatly, stranguria with blood, the difficulty in urination, spits blood, hematochezia, leucorrhea with red and white discharge, erysipelas, carbuncle, traumatic injury, snake bite and insect sting.The extract of Herba Boehmeriae siamensis soaks the artificial Boehmeria sheet wound surface of rat and mice tail end, can use oligemia, and the bleeding time shortens. and the oral or lumbar injection to mice, also has effect same.The acylate that Radix Boehmeriae is contained and alkaloid all have inhibitory action to gram positive bacteria and negative bacterium in vitro.

Radix Rumicis Japonici: hardship, cold in nature, GUIXIN, liver, large intestine channel." Japan hanako materia medica ": " control tinea, kill all worm toxic swellings, the vinegar subsides that rub." effect clearing away heat and loosing the bowels, cooling blood for hemostasis, killing parasites for relieving itching.Cure mainly constipation, hematemesis and epistaxis, discharging fresh blood stool, hemorrhoidal bleeding, metrorrhagia, scabies, bald, carbuncle pyogenic infections from tumour or sore, traumatic injury in vain.Join Cacumen Platycladi, cooling blood for hemostasis, the two mutual reinforcement between is use, treats the blood disorder that of the absurd row of heat in blood forcing blood.Join Alumen, removing toxic substances parasite killing is treated tinea, for carbuncle pyogenic infections from tumour or sore, and eczema scabies, tinea pruritus etc.Radix Rumicis Crispi tincture has certain inhibitory action to multiple pathomycete in vitro.After Radix Rumicis Crispi (kind is not identified) decoct is concentrated, alcoholic extract has inhibitory action to acute lymphoblastic type leukemia, acute monocyte type leukemia and Acute granulocytic leukemia patient hemocyte dehydrogenase.

Folium Callicarpae Formosanae: pungent, bitter, flat.Return liver, spleen, stomach warp.Dissipating blood stasis hemostasis, reducing swelling and alleviating pain.Leaf: for spitting blood, spitting of blood, epistaxis, has blood in stool; External curing traumatic hemorrhage.Root: treating swelling and pain by traumatic injury, rheumatic ostalgia.Supplement to the Herbal: " separate all poisonous substances, carbuncle, sore throat, poison is swollen, lower flaccidity, Serpentis a poisonous snake mentioned in ancient books is bugbite, mad dog poison, and liquor clothes; Also it is swollen that liquor is washed skin ulcer, the long skin of dehematize." " middle traditional Chinese medicines are planted illustrated handbook ": " and hemorrhage to esophageal vein, intestine gastric ulcer is hemorrhage, epistaxis, and wound hinders, pneumorrhagia and the hemorrhage good effect that all has of having tooth pulled out." Folium Callicarpae Formosanae has the effect of blood coagulation of promotion, intestinal blood vessel there is is direct contraction and indirectly plays anastalsis by the stifled resistance of intestinal tube contracture compressing blood vessel.Folium Callicarpae Formosanae all has inhibitory action in various degree to escherichia coli, shigella flexneri, staphylococcus aureus, Hemolytic streptococcus etc.Folium Callicarpae Formosanae can make bleeding time and clotting time shorten, and its hemostasis principle may be that it makes vasoconstriction and platelet count is increased.

Caulis et folium vitis thunbergii: sour, sweet, puckery, flat.Function cures mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness.For hepatitis, appendicitis, mastitis, lung abscess, multiple abscess, rheumatic arthritis; Sore swollen toxin is controlled in external, otitis media, snake bite and insect sting.

Radix Ophiopogonis: sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, the YIN nourishing use that connects with the heart that clears away heart-fire more.These product are sweet cold clear and rich, are apt to control deficiency of stomach-Yin, and dry tongue is thirsty, the indigestion and loss of appetite not hungry card that waits.In addition the also available deficiency of YIN dryness of the intestine of controlling, constipation person.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria is had inhibitory action, can strengthen pituitary adrenal system function, improves organism adaptation ability.Join Radix Adenophorae (Radix Glehniae) Radix Ophiopogonis, lung stomach is ruled together, and has the cool stomach of lung heat clearing, and the good effectiveness of YIN nourishing and the production of body fluid promoting is lacked expectorant, the diseases such as dry laryngopharynx for the dry cough due to lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin.

Rhizoma Polygonati Odorati: sweet in the mouth, property is flat; Attach to the lung and stomach meridians." property of medicine opinion ": " disease cold and heat when main, interior tonifying for the deficiency, removes asthenia exopathogenic heat, and headache is uneasy, adds and good with it." " Japan hanako materia medica ": " and except unhappy, quench the thirst, profit cardiopulmonary, mend five kinds of strain and seven kinds of impairment, deficient, waist foot pain, and it row is fanatical." Compendium of Material Medica: " and main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, and taste void is weary, man's frequent micturition, and consumption of essence, all are deficient." Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.. the steroid glycoside that Rhizoma Polygonati Odorati contains, similar to myocardium effect and Herba Convallariae preparation.Rhizoma Polygonati Odorati glycocide has cardiotonic to isolated frog heart, and the effect of Rhizoma Polygonati Odorati decoct and Rhizoma Polygonati Odorati glycocide are similar.Rhizoma Polygonati Odorati extractum lumbar injection, can strengthen burned mice Peritoneal macrophages Phagocytosis, improves Hemolysin level, improves the breeder reaction of splenocyte to ConA.These product have the laboratory animal of promotion antibody and generate, improve phagocytic percentage and the phagocytic index of macrophage, promote interferon synthetic, suppress growth of bacillus tubercle, blood sugar lowering, blood fat reducing, alleviates atherosclerotic plaque and forms, and makes peripheral blood vessel and coronary dilation, extend hypoxia endurance time, heart tonifying, antioxidation, the anti-ageing effect of waiting for a long time.

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, and dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, frequent fetal movement.

Rhizoma Polygonati Cirrhifolii: Gan Xin is flat.Function cures mainly: nourishing lung-YIN, invigorating the spleen and benefiting QI, the hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control chronic consumptive disease cough, giddy, lack of appetite, seminal emission, night sweat, bleeding not during menses, puerperal, body lost, spits blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, skin ulcer is swollen, scrofula.1. " Shaanxi Chinese herbal medicine ": " spleen reinforcing lung moistening, enriching yin and nourishing kidney, promoting flow of QI and blood, astringing to arrest bleeding, the sterilization of drawing out pus by applying a plaster to the affected part.Control insufficiency of the spleen few food, cough due to deficiency of the lung, dizzy bodily pain, seminal emission night sweat, metrorrhagia leucorrhea, furuncle is from the beginning of, scrofula." 2. " Ningxia Chinese herbal medicine handbook ": " hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control cough and spit blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, sore swollen toxin." 3. " Chinese herbal medicine is commonly used in Tibet ": " strengthens the spleen and stomach, the lung moistening and production of body fluid promoting.Control all empty deficiencies, chronic consumptive disease cough, muscles and bones flaccidity is soft." 4. Nanchuan " conventional Chinese herbal medicine handbook ": " the kidney invigorating lung benefiting, benefiting qi and nourishing yin.Deficient qi and blood after managing property."

Glycine max (L.) Merr.: come from " Treatise on Dietetic Therapy ", sweet; Temperature.Return spleen; Stomach warp.Function cures mainly: expelling wind and removing dampness; Invigorating the spleen and benefiting QI.Main arthralgia chiefly caused by damp pathogen; Joint rash pain; Insufficiency of the spleen lack of appetite; Gastral cavilty harm is vexed; Scrotum pruritus due to damp pathogen.

Herba Pimpinellae thellungianae: " northern Shensi medical herbs ", sweet in the mouth begin to be loaded in; Pungent; Warm in nature.Function cures mainly: invigorating the spleen and benefiting QI; Tranquilizing by nourishing the heart; Eliminating phlegm and stopping cough.Main Keshan disease; Heart reconstruction; Breathe hard; Cough with asthma.

Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

 

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

 

Embodiment 1 capsule

The embodiment of the present invention provides a kind of pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenia purpura, raw medicinal material by following parts by weight is made: Herba Andrographis 14 weight portions, Folium Isatidis 15 weight portions, Radix Rumicis Patientiae 17 weight portions, Herba Gonostegiae hirtae 14 weight portions, Flos Trollii 7 weight portions, Preparatum Glycyrrhizae's 11 weight portions, Herba Houttuyniae 11 weight portions, Herba Euphorbiae Humifusae 12 weight portions, Herba Potentillae Chinensis 16 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 14 weight portions, Radix Rehmanniae 15 weight portions, Umbillcaria esculenta 11 weight portions, Herba Portulacae 14 weight portions, Flos Sophorae 8 weight portions, Herba Cassiae Mimosoidis 11 weight portions, Aloe 10 weight portions, Fructus Cannabis 7 weight portions, Herba Hyperici 13 weight portions, Pollen Typhae 8 weight portions, Radix Sanguisorbae 6 weight portions, Rhizoma Imperatae 9 weight portions, Radix Boehmeriae 7 weight portions, Radix Rumicis Japonici 13 weight portions, Folium Callicarpae Formosanae 7 weight portions, Caulis et folium vitis thunbergii 9 weight portions, Radix Ophiopogonis 15 weight portion and Rhizoma Polygonati Odorati 13 weight portions.

Its preparation method is:

The first step, is mixed in proportion each raw medicinal material in described pharmaceutical composition, the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 90%, and reflux 2 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 90% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1.5 times of described medicinal residues quality again, reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1.5 hours, pulverizes, and sieves, and obtains 350 object micropowders;

The 3rd step, successively adds Pulvis Talci, magnesium stearate in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.2:0.3, described capsule 's content is incapsulated in housing, and obtain capsule finished product.

 

Embodiment 2 tablets

The embodiment of the present invention provides a kind of pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenia purpura, raw medicinal material by following parts by weight is made: Herba Andrographis 13 weight portions, Folium Isatidis 16 weight portions, Radix Rumicis Patientiae 17 weight portions, Herba Gonostegiae hirtae 14 weight portions, Flos Trollii 6 weight portions, Preparatum Glycyrrhizae's 9 weight portions, Herba Houttuyniae 11 weight portions, Herba Euphorbiae Humifusae 12 weight portions, Herba Potentillae Chinensis 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 14 weight portions, Radix Rehmanniae 15 weight portions, Umbillcaria esculenta 11 weight portions, Herba Portulacae 12 weight portions, Flos Sophorae 7 weight portions, Herba Cassiae Mimosoidis 11 weight portions, Aloe 9 weight portions, Fructus Cannabis 6 weight portions, Herba Hyperici 13 weight portions, Pollen Typhae 8 weight portions, Radix Sanguisorbae 4 weight portions, Rhizoma Imperatae 11 weight portions, Radix Boehmeriae 6 weight portions, Radix Rumicis Japonici 14 weight portions, Folium Callicarpae Formosanae 9 weight portions, Caulis et folium vitis thunbergii 10 weight portions, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 13 weight portions, the Rhizoma Atractylodis Macrocephalae 16 weight portions, Rhizoma Polygonati Cirrhifolii 14 weight portions, Glycine max (L.) Merr. 7 weight portions, Herba Pimpinellae thellungianae 11 weight portions and Poria 14 weight portions.

The dosage form of described pharmaceutical composition is tablet, and its preparation method is:

The first step, is mixed in proportion each raw medicinal material in described pharmaceutical composition, the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 90%, and reflux 3 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 90% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2 times of described medicinal residues quality again, reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1.5 hours, pulverizes, and sieves, and obtains 400 object micropowders;

The 3rd step, the micropowders that second step is obtained, adds with respect to the microcrystalline Cellulose of 0.2 times of its quality, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.02 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

 

Toxicity test

One, acute toxicity test

Test material: animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the tablet of the embodiment of the present invention 2.

Method: 1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, 10 every group, male and female half and half, dissolve tablet adding distil water, are made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.Tablet adding distil water is dissolved, be made into maximum concentration, by the maximum tolerated dose of animal, fill with hello device and can twitch and be as the criterion to inject.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Result of the test: LD50 calculate in the time giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Two, aggregate toxicity experiment:

The capsule of Chinese medicine embodiment 1 of the present invention to mice by 7.69,19.18 and 15 weeks (1.0ml/100g body weight of 43.21g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and the each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation oral capsule of the present invention is to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

 

Clinical trial

Meet bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura patient totally 186 people of inclusive criteria, diagnostic criteria through the selection of clinical data, age 7-32 year, 11.9 years old mean age, course of disease 10-50 days, man's 87 examples, female's 99 examples, are in August, 2011-2013 the court's in-patient department in year June and out-patient.Patient is divided into three groups at random, every group of 62 examples, between each experimental group, physical data not statistically significant, has comparability.

Diagnostic criteria: according to the diagnostic criteria of formulating in Chinese hematopathy association in 1986 whole nation Thrombosis and hemostasis academic conference, specifically have following 6 points: 1. onset has infection history in first 1 ~ 3 week, especially virus infection history.2. there is suddenly petechia, ecchymosis or other bleedings in whole skin, mucosa.3. spleen not quite or only slightly increases.4. many laboratory examination thrombocytopenia.Acute < 20 × 109/L, chronic type is between (20 ~ 40) × 109/L.5. bone marrow smear and section show that megalokaryocyte increases, also can be normal, and companion's dysmaturity.6. following 5 possess any one person: 1. Prednisone Therapy is effective.2. cut spleen treatment effectively.3. PAIg increases.4. the relevant C3 of platelet increases.5. life-span determination of blood platelet shortens.Be diagnosed as idiopathic thrombocytopenic purpura according to foregoing, and be acute according to concrete symptom analysis, and meet traditional Chinese medical science inclusive criteria: livid purple speckle or speckle appear in skin, or with epistaxis, bleeding from the gum, have blood in stool, hematuria, or have heating, and thirsty, constipation, red tongue, yellow fur, the dizzy number of arteries and veins.

Therapeutic Method:

Embodiment group 1: use the capsule of the embodiment of the present invention 1 to treat, every day 1-3 time, each 1-3 grain, treats 1-6 month continuously; Adapt to adjust every day 1-2 time in 7-16 year, 1-2 grain at every turn according to patient age, the state of an illness; 17-32 year, every day 2-3 time, each 2-3 grain;

Embodiment group 2: use the tablet of the embodiment of the present invention 2 to treat, every day 1-3 time, each 1-3 sheet, treats 1-6 month continuously; Adapt to adjust every day 1-2 time in 7-16 year, 1-2 sheet at every turn according to patient age, the state of an illness; 17-32 year, every day 2-3 time, each 2-3 sheet;

Matched group: use prednisone acetate tablets, every day 1.0-1.5mg/kg, points 2 times are oral, treat continuously 1-6 month.

Criterion of therapeutical effect: recovery from illness: PTL>=100 × 10 ⁹/ L, without bleeding; Effective: PTL>=100 × 10 ⁹/ L or more former level rise 30 × 10 ⁹/ L, without or substantially without bleeding; Effective: PLT has rising, bleeding improves, and continues more than two weeks; Invalid: PLT and bleeding are without improving or worsening.

Therapeutic outcome:

Referring to table 1 and table 2, as can be seen from Table 1, adopt medicine composite for curing bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura of the present invention, on therapeutic effect, there is significant improvement with respect to conventional medicament; As can be seen from Table 2, adopt medicine composite for curing bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura of the present invention, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.

Each group of table 1 is treated respectively Clinical efficacy comparison example after 6 months

Group	Number of cases	Cure	Effective	Effectively	Invalid	Effective percentage
							Embodiment group 1	62	37	15	8	2	96.8%
Embodiment group 2	62	40	16	6	0	100%
							Matched group	62	23	13	9	17	72.6%

Each group of table 2 is treated respectively and is cured and effective number and time comparative example (%) for 6 months

Group	Number of cases	0-1 month	2-4 month	5-6 month
					Embodiment group 1	52	7（13.5%）	26（50.0%）	19（36.5%）
Embodiment group 2	56	12（21.4%）	31（55.4%）	13（23.2%）
					Matched group	36	1（2.8%）	10（27.8%）	25（69.4%）

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect.

 

Model case

Grandson, man, 8 years old, came to go to a doctor in November, 2012, and medical front first quarter moon flu, finds after recovery from illness that whole skin mucosa engenders ecchymosis petechia, after 3 days, with hematuria phenomenon, comes to go to a doctor at once.The Lactoferrin 116g/L that has a blood test, erythrocyte 4.3 × 10 ¹²/ L, leukocyte 6.6 × 10 ⁹/ L, platelet 3.1 × 10 ⁹/ L, with hematuria, thirsty, red tongue, yellow fur, the dizzy number of arteries and veins.Be diagnosed as bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura, use the capsule of the embodiment of the present invention 2 to treat, every day 2 times, each 1, the bimester of taking 2 continuously after, symptom is clearly better, and continues to take check in 1 month, platelet 157 × 10 ⁹/ L, recovery from illness.After healing, follow up a case by regular visits to half a year, not recurrence.

 

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (7)

1. be used for the treatment of the pharmaceutical composition of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Herba Andrographis, Folium Isatidis, Radix Rumicis Patientiae, Herba Gonostegiae hirtae, Flos Trollii, Preparatum Glycyrrhizae, Herba Houttuyniae, Herba Euphorbiae Humifusae, Herba Potentillae Chinensis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rehmanniae, Umbillcaria esculenta, Herba Portulacae, Flos Sophorae, Herba Cassiae Mimosoidis, Aloe, Fructus Cannabis, Herba Hyperici, Pollen Typhae, Radix Sanguisorbae, Rhizoma Imperatae, Radix Boehmeriae, Radix Rumicis Japonici, Folium Callicarpae Formosanae, Caulis et folium vitis thunbergii, Radix Ophiopogonis and Rhizoma Polygonati Odorati.

2. the pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura according to claim 1, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Andrographis 11-18 weight portion, Folium Isatidis 12-18 weight portion, Radix Rumicis Patientiae 15-20 weight portion, Herba Gonostegiae hirtae 12-17 weight portion, Flos Trollii 5-11 weight portion, Preparatum Glycyrrhizae 7-16 weight portion, Herba Houttuyniae 6-17 weight portion, Herba Euphorbiae Humifusae 10-15 weight portion, Herba Potentillae Chinensis 12-17 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 12-17 weight portion, Radix Rehmanniae 10-20 weight portion, Umbillcaria esculenta 8-14 weight portion, Herba Portulacae 8-18 weight portion, Flos Sophorae 5-12 weight portion, Herba Cassiae Mimosoidis 6-17 weight portion, Aloe 8-12 weight portion, Fructus Cannabis 4-9 weight portion, Herba Hyperici 9-17 weight portion, Pollen Typhae 5-12 weight portion, Radix Sanguisorbae 2-7 weight portion, Rhizoma Imperatae 7-15 weight portion, Radix Boehmeriae 5-9 weight portion, Radix Rumicis Japonici 10-16 weight portion, Folium Callicarpae Formosanae 5-11 weight portion, Caulis et folium vitis thunbergii 6-16 weight portion, Radix Ophiopogonis 10-20 weight portion and Rhizoma Polygonati Odorati 9-16 weight portion.

3. the pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Andrographis 14 weight portions, Folium Isatidis 15 weight portions, Radix Rumicis Patientiae 17 weight portions, Herba Gonostegiae hirtae 14 weight portions, Flos Trollii 7 weight portions, Preparatum Glycyrrhizae's 11 weight portions, Herba Houttuyniae 11 weight portions, Herba Euphorbiae Humifusae 12 weight portions, Herba Potentillae Chinensis 16 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 14 weight portions, Radix Rehmanniae 15 weight portions, Umbillcaria esculenta 11 weight portions, Herba Portulacae 14 weight portions, Flos Sophorae 8 weight portions, Herba Cassiae Mimosoidis 11 weight portions, Aloe 10 weight portions, Fructus Cannabis 7 weight portions, Herba Hyperici 13 weight portions, Pollen Typhae 8 weight portions, Radix Sanguisorbae 6 weight portions, Rhizoma Imperatae 9 weight portions, Radix Boehmeriae 7 weight portions, Radix Rumicis Japonici 13 weight portions, Folium Callicarpae Formosanae 7 weight portions, Caulis et folium vitis thunbergii 9 weight portions, Radix Ophiopogonis 15 weight portion and Rhizoma Polygonati Odorati 13 weight portions.

4. according to the pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura described in claim 1-3 any one, it is characterized in that, described pharmaceutical composition also comprises the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Cirrhifolii, Glycine max (L.) Merr., Herba Pimpinellae thellungianae and Poria, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Andrographis 11-18 weight portion, Folium Isatidis 12-18 weight portion, Radix Rumicis Patientiae 15-20 weight portion, Herba Gonostegiae hirtae 12-17 weight portion, Flos Trollii 5-11 weight portion, Preparatum Glycyrrhizae 7-16 weight portion, Herba Houttuyniae 6-17 weight portion, Herba Euphorbiae Humifusae 10-15 weight portion, Herba Potentillae Chinensis 12-17 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 12-17 weight portion, Radix Rehmanniae 10-20 weight portion, Umbillcaria esculenta 8-14 weight portion, Herba Portulacae 8-18 weight portion, Flos Sophorae 5-12 weight portion, Herba Cassiae Mimosoidis 6-17 weight portion, Aloe 8-12 weight portion, Fructus Cannabis 4-9 weight portion, Herba Hyperici 9-17 weight portion, Pollen Typhae 5-12 weight portion, Radix Sanguisorbae 2-7 weight portion, Rhizoma Imperatae 7-15 weight portion, Radix Boehmeriae 5-9 weight portion, Radix Rumicis Japonici 10-16 weight portion, Folium Callicarpae Formosanae 5-11 weight portion, Caulis et folium vitis thunbergii 6-16 weight portion, Radix Ophiopogonis 10-20 weight portion, Rhizoma Polygonati Odorati 9-16 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Rhizoma Polygonati Cirrhifolii 13-17 weight portion, Glycine max (L.) Merr. 5-12 weight portion, Herba Pimpinellae thellungianae 8-15 weight portion and Poria 10-18 weight portion.

5. according to the pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura described in claim 1-4 any one, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Andrographis 13 weight portions, Folium Isatidis 16 weight portions, Radix Rumicis Patientiae 17 weight portions, Herba Gonostegiae hirtae 14 weight portions, Flos Trollii 6 weight portions, Preparatum Glycyrrhizae's 9 weight portions, Herba Houttuyniae 11 weight portions, Herba Euphorbiae Humifusae 12 weight portions, Herba Potentillae Chinensis 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 14 weight portions, Radix Rehmanniae 15 weight portions, Umbillcaria esculenta 11 weight portions, Herba Portulacae 12 weight portions, Flos Sophorae 7 weight portions, Herba Cassiae Mimosoidis 11 weight portions, Aloe 9 weight portions, Fructus Cannabis 6 weight portions, Herba Hyperici 13 weight portions, Pollen Typhae 8 weight portions, Radix Sanguisorbae 4 weight portions, Rhizoma Imperatae 11 weight portions, Radix Boehmeriae 6 weight portions, Radix Rumicis Japonici 14 weight portions, Folium Callicarpae Formosanae 9 weight portions, Caulis et folium vitis thunbergii 10 weight portions, Radix Ophiopogonis 15 weight portion, Rhizoma Polygonati Odorati 13 weight portions, the Rhizoma Atractylodis Macrocephalae 16 weight portions, Rhizoma Polygonati Cirrhifolii 14 weight portions, Glycine max (L.) Merr. 7 weight portions, Herba Pimpinellae thellungianae 11 weight portions and Poria 14 weight portions.

6. according to the pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura described in claim 1-5 any one, it is characterized in that, the dosage form of described pharmaceutical composition is capsule, and its preparation method is:

The first step, is mixed in proportion each raw medicinal material in described pharmaceutical composition, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, successively adds Pulvis Talci, magnesium stearate in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5:0.15～0.5, and described capsule 's content is incapsulated in housing, obtain capsule finished product.

7. according to the pharmaceutical composition that is used for the treatment of bleeding due to blood-heat type acute idiopathic thrombocytopenic purpura described in claim 1-5 any one, it is characterized in that, the dosage form of described pharmaceutical composition is tablet, and its preparation method is:

The first step, is mixed in proportion each raw medicinal material in described pharmaceutical composition, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.