CN104689101A - Traditional Chinese medicine preparation for treating latent glomerulonephritis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating latent glomerulonephritis. The traditional Chinese medicine preparation is prepared from honeysuckle flower, fructus forsythia, cicada slough, hairyvein agrimony, lalang grass rhizome, stiff silkworm, dried rehmannia root, moutan bark, tuckahoe, rhizoma anemarrhenae, cortex phellodendri, dandelion, oldenlandia diffusa, giant knot weed, setose thistle, field thistle, verbena, root of common peony, white paeony root, radices lithospermi, plantain herb, the root of kudzu vine, salvia miltiorrhiza and radix glycyrrhizae in a certain weight proportion. The traditional Chinese medicine preparation has the effects of clearing heat and removing toxicity, cooling blood and hemostasis, and nourishing yin and generating body fluid, and the latent glomerulonephritis can be effectively treated.

Description

One treats invisible brightic Chinese medicine preparation and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to one and treat invisible brightic Chinese medicine preparation, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Latent glomerulonephritis also referred to as asymptomatic proteinuria or (with) albuminuria, patient without edema, hypertension and renal function injury, and only show as glomerule source property hematuria or (with) albuminuretic one group of glomerulopathy.Acute postinfectious glomerulonephritis, be called for short acute nephritis, be one group with Acute onset, hematuria, albuminuria, hypertension, edema, oliguria, renal dysfunction are the clinical syndrome of feature, also known as acute nephritic syndrome.Its morbidity often comes across infection, mainly after streptococcal infection, belongs to Immune complexes nephritis.Primary disease is more common in Children and teenager, middle age and old age comparatively rare, M-F about 2: 1.Primary disease mostly is and distributes, and its morbidity season is relevant with the morbidity season that forerunner infects.

The large pathogenesis of invisible glomerulonephritis it be unclear that, think at present and reflect relevant more than infection and immunity, and this sick onset mostly concealment, or there is gross hematuria suddenly, without other urinary symptoms, renal function is mostly normal, main clinical manifestation is abnormal for urinating, and mainly contain asymptomatic proteinuria, asymptomatic proteinuria and albuminuria, asymptomatic proteinuria three kinds of forms clinically, its state of an illness is touching, recurrent exerbation, brings serious puzzlement to patient.

Traditional Chinese medical science aspect "Nei Jing" is discussed hematuria the earliest, think " born of the same parents' heat is moved in bladder; then infirmity, hematuria ", the traditional Chinese medical science thinks that hematuria and kidney and bladder relation are the closest, and it is also closer in other Zang-Fu relationships, kidney yin is damaged, dynamic in fire mutually, yin collaterals of burning, add that patient's body constitution is weak, just easily cause this disease.

At present clinically for invisible brightic treatment mainly symptomatic treatment, with some diuresis, blood pressure lowering, the medicine of blood potassium falls, but these medicines can only stop the generation of clinical symptoms, fundamentally cannot carry out conditioning health, reach the object of thoroughly curing, bring serious burden to the family of patient and patient.

Summary of the invention

The object of the present invention is to provide one to treat invisible brightic Chinese medicine preparation, this Chinese medicine preparation has determined curative effect for invisible glomerulonephritis, soon effective, short treating period, and price is low, the feature that side effect is little.

Another object of the present invention is to provide the preparation method of the invisible brightic Chinese medicine preparation of this treatment.

Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of invisible brightic Chinese medicine preparation repeatedly, the present invention selects Flos Lonicerae, Fructus Forsythiae, Periostracum Cicadae, Herba Agrimoniae, Rhizoma Imperatae, Bombyx Batryticatus, Radix Rehmanniae, Cortex Moutan, Poria, the Rhizoma Anemarrhenae, Cortex Phellodendri, Herba Taraxaci, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati, Radix Cirsii Japonici, Herba Cirsii, Herba Verbenae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Herba Plantaginis, Radix Puerariae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae combines, make to produce synergism between each medicine, there is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of YIN nourishing and the production of body fluid promoting, thus can effectively treat invisible glomerulonephritis.

The effect of Chinese medicine of the present invention:

Wherein:

Flos Lonicerae: the flower that dry flower or band for caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. are just opened.Nature and flavor: sweet, cold.Return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-dispelling heat-dissipating.The dysentery caused for pyretic toxicity is had blood in stool, hematuria.The poly-intestinal of pyretic toxicity knot, enter blood system, then dysentery is had blood in stool.Flos Lonicerae energy removing heat from blood and relieving heat toxin, therefore dysentery can be treated have blood in stool, normal with Flos Lonicerae parch to black clinically, close Radix Scutellariae, Rhizoma Coptidis, the Radix Paeoniae Alba, Herba Portulacae is equivalent uses.

Fructus Forsythiae: be the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Nature and flavor: bitter, are slightly cold.Return lung, the heart, small intestine meridian.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.Fructus Forsythiae is normal with the same use of Flos Lonicerae, Fructus Forsythiae bitter in the mouth cool in nature, gently clearly to float, and can control all heat of the part of the body cavity above the diaphragm housing the heart and lungs, outstanding energy removing toxicity for eliminating carbuncles and eliminating stagnation, therefore is the key medicine of persons particularly liable to develop skin infection.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.Antibacterial action: Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.

Periostracum Cicadae: exuviae shell when the larva for cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius sprouts wings.Nature and flavor: sweet, cold.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, rash are antipruritic, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion.This product a surname is loose to be sent out thoroughly, wind-dispelling heat-dissipating, and rash antipruritic can be used for treats measles, eczema etc.

Herba Agrimoniae: be the aerial parts of Rosaceae herbaceos perennial Agrimony Agrimonia pilosa Ledeb..Nature and flavor: bitter, puckery, flat.GUIXIN, Liver Channel.Effect: astringing to arrest bleeding, removing toxic substances, dysentery relieving, parasite killing cuts cruel.For hemoptysis, spit blood, control epistaxis and have specially good effect, malaria, de-power impairment caused by overstrain, carbuncle.This product puckery convergence and property is put down, no matter the going out blood disorder and all can apply of cold and heat and asthenia and sthenia.

Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.Dysuria, due to interior-heat also, pyrolysis then just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach is explained by oneself, and body fluid is raw and yearningly also stop.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, and removing heat from blood and blood, then collapse spontaneous recovery.Heat in blood is absurd row then, overflow upper orifices for telling, for coughing up, be epistaxis, bleeding from the gum, removing heat from blood and blood, then all cards are from removing.Strengthening the spleen invigorating middle warmer, diuresis, therefore swollen jaundice of also harnessing the river, and hold concurrently reason typhoid fever hiccup also.

Bombyx Batryticatus: the larva for Bombycidae insecticide silkworm Bombyx mori Linnaeus. 4 ~ 5 age infects (or artificial vaccination) muscardine Beauveria bassiana(Bals.) Vuillant and lethal larva dry body.Nature and flavor: salty, pungent are flat.Return liver, lung, stomach warp.Effect: expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Cure mainly: apoplectic aphasia, middle tuyere nose eye are oblique.

Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Nature and flavor: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Can be used for Tianjin wound thirsty, interior-heat is quenched one's thirst.This product is sweet cold, can among heat clearing away YIN nourishing and the production of body fluid promoting, cold in nature and enter blood system, can not only the heat of clearing heat in YING system blood system and removing heat from blood, and sweet in the mouth is cold in nature can promote the production of body fluid, and has the effect of nourishing YIN and clearing away heat.Research shows: the existing anastalsis of Radix Rehmanniae, there is blood coagulation resisting function again, the yellow needles of Radix Rehmanniae ethanol extraction gained can shorten rabbit clotting time, experiment proves: the water decoction of Radix Rehmanniae, Radix Rehmanniae Preparata, fresh rehmannia charcoal, charred RADIX REHMANNIAE obviously can shorten clotting time, each other also there was no significant difference.In domestic Radix Rehmanniae Preparata wherein one have antithrombase effect, two kinds have and activate the effect of fibrinolytic system, can obviously to the generation of antithrombase and endotoxin induced rat DIC, but equal platelet-free agglutination.

Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter, cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.The power of Cortex Moutan removing heat from blood is stronger, can be purified the blood a point excess-heat, can control fever due to yin deficiency again, this product cold nature, energy clearing heat in YING system divides, blood system excess-heat, have the merit of cooling blood for hemostasis, and Cortex Moutan is pungent cold, is apt to into blood system, can removing heat from blood with hemostasis, can invigorate blood circulation with dissipating blood stasis again, the kind logical heat in blood stasis of blood is stagnant, and normal and Radix Rehmanniae, Radix Paeoniae Rubra are used together.

Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.

The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bunge..Nature and flavor: bitter, sweet, cold.Return lung, stomach, kidney channel.Effect: clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.For fever due to yin deficiency, cough due to consumptive disease and the disease such as to quench one's thirst.Rhizoma Anemarrhenae energy purte the white and nourishing kidney, therefore can not only excess-heat clearly, and can clearind deficient heat.Many and the same use of Cortex Phellodendri, allocates in drugs for nourishing yin, as ZHIBAI DIHUANG WAN, controls the disease such as hyperactivity of fire caused by deficiency of YIN, hectic fever hectic fever due to YIN-deficiency clinically.

Cortex Phellodendri: be the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..Nature and flavor: bitter, cold.Return kidney, bladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Modern pharmacology is studied: Cortex Phellodendri water decoction or alcohol preserved material, in vitro to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, Diplococcus pneumoniae, anthrax bacillus, vibrio cholera, diphtheria corynebacterium, bacillus subtilis, escherichia coli, bacillus pyocyaneus, Bacillus typhi, Salmonella paratyphi, meningococcus etc., all have inhibitory action in various degree.Experiment also shows, Cortex Phellodendri has stronger inhibitory action to shigella flexneri, dysentery bacterium.In addition, Cortex Phellodendri decoct, water logging agent all have inhibitory action in various degree in external to multiple pathogenic dermatophytes, trichomonas vaginitis etc.This product can heat clearing and damp drying, again can eliminating fire and detoxication, for oral administration, external is all effective, and Cortex Phellodendri has the effect of broad-spectrum antiseptic.

Herba Taraxaci: Herba Taraxaci, also known as bed-wetting grass, is feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or the dry herb belonging to several plants together.Nature and flavor: sweet, micro-hardship, cold.Return liver, stomach warp.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Herba Taraxaci has effect of antiinflammatory, antibacterial, antitumor, heat-clearing and toxic substances removing, and applied range on modern clinic, makes good use of.

Herba Hedyotidis Diffusae: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.].Nature and flavor: sweet, light, cool.Enter stomach, large intestine, small intestine meridian.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.Comparatively high inhibition effect is had in vitro to the tumor cell of acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type.

Rhizoma Polygoni Cuspidati: be polygonaceae plant Rhizoma Polygoni Cuspidati Polygonum cuspidatum Sieb. et Zucc., dry rhizome and root.Spring, Qiu Erji excavate, and removing fibrous root, cleans, take advantage of short section of fresh-cut or sheet, dry.Nature and flavor: micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.Effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.Effective ingredient has antipyretic-antalgic, and the effect of antiinflammatory.

Radix Cirsii Japonici: be Compositae artichoke plant Radix Cirsii Japonici Cirsium japonicum DC., be used as medicine with herb and root.Nature and flavor: sweet are cool.GUIXIN; Liver Channel.Function cures mainly: cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.Cure mainly: epistaxis, spitting of blood, spit blood, hematuria, dysfunctional uterine hemorrhage, postpartum hemorrhage, hepatitis, nephritis, mastitis, traumatic injury; Traumatic hemorrhage is controlled in external, carbuncle furuncle and phyma poison.

Herba Cirsii: be the dry aerial parts (wounded in the battle herb) of Compositae field thistle platymiscium field thistle Cephalanoplos segetum (Bunge) Kitam. [Cirsium segetum Bunge], root stock also can be used as medicine.Nature and flavor: sweet, bitter, cold.GUIXIN, Liver Channel.Effect: herb: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Root stock: hepatitis." Records of Tradition Chinese and Western Medicine in Combination ": fresh Herba Cirsii root, cool in naturely makes moist, and is apt to into blood system, the heat to purify the blood most point, all hemoptysis, haematemesis, epistaxis, two just hematochezia because of hot person, take there's no one who doesn't or isn't vertical.Kindly again control pneumonopathy tuberculosis, no matter what, use all suitable phase, namely alonely also can to prove effective.And control the swollen pain of all skin infection, flower willow poison drenches, the puckery pain of hematochezia.Covering its property not only can cooling blood for hemostasis, and holding concurrently can promoting blood circulation and detoxication, is have above all effects also.The property of its cool profit, kind nourishing YIN and benefiting blood, controls fever due to deficiency of blood again.To female in metrorrhagia leucorrhea with bloody discharge, its because of hot person with also imitate.

Herba Verbenae: be the dry aerial parts of Verbenaceae Herba Verbenae Verbena officinalis L..Nature and flavor: bitter, cool.Return liver, spleen channel.Effect: promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria." Bencao Jingshu ": Herba Verbenae is originally the medicine of removing heat from blood removing blood stasis.Bottom skin ulcer person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear.

Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor: bitter, are slightly cold.Return Liver Channel.Effect: eliminating stasis to stop pain, clearing away heat and cooling blood, detumescence.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.This product hardship is fallen, and has effect of promoting blood circulation to restore menstrual flow, loose Yu Xiao wei, row stagnation pain.Often join Cortex Moutan.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, this product bitter cold, main enter Liver Channel, be apt to away blood system, can clearing away liver-fire, except blood system is hot and suffocating and have the merit of removing heat from blood, hemostasis, dissipating blood stasis speckle removing.

The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.

Radix Arnebiae (Radix Lithospermi): be the root of comfrey Radix Arnebiae (Radix Lithospermi) (gromwell root) (Lithosper-mum erythorhizon sieb. et zucc.) and lithospermum euchromum Royle (Radix Arnebiae) [Arnebia euchroma(Royle) Johnst.].Nature and flavor: cold, sweet, salty.Gui Jing: GUIXIN, Liver Channel.Function: removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.

Herba Plantaginis: be the dry herb of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Nature and flavor: sweet, cold.Return liver, kidney, lung, small intestine meridian.Effect: clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.For edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.Herba Plantaginis has certain diuresis, and has antibacterial and effect that is antiinflammatory, and Herba Plantaginis water logging agent blocks bacterium etc. to Trichophyton concentricunm, ulotrichy microspore tinea bacterium, starlike slave in vitro inhibitory action in various degree.The flat board method that burrows proves that staphylococcus aureus is extremely sensitive to Herba Plantaginis, S. sonnei medium sensitivity, escherichia coli, bacillus pyocyaneus, Bacillus typhi slight sensitive.

Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Nature and flavor: cool, sweet, pungent.Enter spleen, stomach warp.Effect: induce sweat and bring down a fever, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Radix Puerariae is sweet pungent cool in nature, and lightly floating, it is loose to rise, and enters taste warp, has relieving the exterior syndrome by diaphoresis, the merit of expelling pathogenic factors from muscles for reducing heat.

Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.Containing cryptotanshinone, dihydrotanshinone in red sage formulation, there is inhibitory action to external staphylococcus, escherichia coli, degeneration bacillus.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, to the hypertrophy eliminating hepatic fibrosis connective tissue, also may have certain effect.

Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: Flos Lonicerae in side, Fructus Forsythiae heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, Periostracum Cicadae wind-dispelling heat-dissipating, Herba Agrimoniae astringing to arrest bleeding, Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting diuresis, Bombyx Batryticatus dissipating phlegm and resolving masses, above Six-element is monarch drug altogether, plays heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, Flos Lonicerae, Fructus Forsythiaes etc. have broad-spectrum antibacterial action, are equivalent to antibiotic medicine, and can not produce drug resistance, little to the actual bodily harm of patient, Herba Agrimoniae, Rhizoma Imperataes etc. have effect of cooling blood for hemostasis, can reduction of patient hematuria, albuminuretic symptom, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, Cortex Moutan clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, Poria spleen invigorating mind calming, Rhizoma Anemarrhenae clearing away heat-fire, promote the production of body fluid and moisturize, Cortex Phellodendri heat clearing and damp drying, Herba Taraxaci, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, inducing diuresis to remove edema, above seven tastes are ministerial drug altogether, and invisible glomerulonephritis is many to be damaged by kidney yin, dynamic in fire mutually, to burn yin collaterals, injure caused by kidney yin, the main water of kidney, deficiency of kidney-QI, dysfunction of the kidney in storing essence, blood can be urinated with under gas in hyperamization, and factor ministerial drug, while increase monarch drug drug effect, also has YIN nourishing and the production of body fluid promoting, effect of clearing away heat-fire, gets rid of pathogenic heat in body, accelerates the improvement of patient.Rhizoma Polygoni Cuspidati expelling wind and removing dampness, Radix Cirsii Japonici, Herba Cirsii cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling, Herba Verbenae inducing diuresis to remove edema, Radix Paeoniae Rubra, Radix Paeoniae Alba eliminating stasis to stop pain, clearing away heat and cooling blood, Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, Herba Plantaginis clearing away heat and promoting diuresis, Radix Puerariae induces sweat and brings down a fever, Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, a few taste is adjuvant drug altogether above, nurses one's health the health of patient with cooling blood for hemostasis, eliminating stasis to stop pain, and has and prevent monarch drug ministerial drug too high strong, drugs on patients is avoided to cause the effect of otherwise injury, to accelerate the improvement of patient body.Radix Glycyrrhizae priming is returned through, coordinating the actions of various ingredients in a prescription, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, YIN nourishing and the production of body fluid promoting, can effectively treat invisible glomerulonephritis.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Flos Lonicerae 10-20 part, Fructus Forsythiae 13-23 part, Periostracum Cicadae 3-9 part, Herba Agrimoniae 25-35 part, Rhizoma Imperatae 19-29 part, Bombyx Batryticatus 4-14 part, Radix Rehmanniae 10-20 part, Cortex Moutan 10-20 part, Poria 10-20 part, Rhizoma Anemarrhenae 7-17 part, Cortex Phellodendri 7-17 part, Herba Taraxaci 15-25 part, Herba Hedyotidis Diffusae 13-23 part, Rhizoma Polygoni Cuspidati 13-23 part, Radix Cirsii Japonici 10-20 part, Herba Cirsii 10-20 part, Herba Verbenae 10-20 part, Radix Paeoniae Rubra 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, Herba Plantaginis 15-25 part, Radix Puerariae 10-20 part, Radix Salviae Miltiorrhizae 19-29 part, Radix Glycyrrhizae 3-9 part.

Wherein be preferably: Flos Lonicerae 15 parts, Fructus Forsythiae 18 parts, Periostracum Cicadae 6 parts, Herba Agrimoniae 30 parts, Rhizoma Imperatae 24 parts, Bombyx Batryticatus 9 parts, Radix Rehmanniae 15 parts, Cortex Moutan 15 parts, 15 parts, Poria, the Rhizoma Anemarrhenae 12 parts, Cortex Phellodendri 12 parts, Herba Taraxaci 20 parts, Herba Hedyotidis Diffusae 18 parts, Rhizoma Polygoni Cuspidati 18 parts, Radix Cirsii Japonici 15 parts, Herba Cirsii 15 parts, Herba Verbenae 15 parts, Radix Paeoniae Rubra 15 parts, the Radix Paeoniae Alba 15 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Herba Plantaginis 20 parts, Radix Puerariae 15 parts, Radix Salviae Miltiorrhizae 24 parts, Radix Glycyrrhizae 6 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is pill, and its preparation method is as follows:

Step one: by weight proportion of the present invention, takes Fructus Forsythiae bundle and becomes medicated bag, be put in water and soak 30-40 minute, filters, for subsequent use;

Step 2: by weight proportion of the present invention, takes Poria and grinds, and crosses 180 mesh sieves, for subsequent use;

Step 3: by weight proportion of the present invention, take Rhizoma Imperatae, Radix Rehmanniae, Cortex Moutan, the Rhizoma Anemarrhenae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Radix Puerariae, Radix Salviae Miltiorrhizae is put into after marmite adds step one immersion and is remained cold water, exceed powder 3 centimetres, after being fried boiling with high heat, again with 40-50 minute at a simmer, filter, obtain filtrate, the water of 3 centimetres is added in residue medicinal residues, then Herba Agrimoniae is added, Bombyx Batryticatus, Herba Taraxaci, Herba Hedyotidis Diffusae, Radix Cirsii Japonici, Herba Cirsii, Herba Verbenae, Herba Plantaginis, Radix Glycyrrhizae and a kind of medicated bag of step, decoct 30 minutes, finally add Flos Lonicerae, Periostracum Cicadae decocts 10 minutes, filter, waste, merge twice filtrate, then concentrate and add ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, for subsequent use,

Step 4: the thick paste by gained concentration of liquid medicine in step 3 being relative density 1.15 ~ 1.20 under 75 DEG C of environment, by gained powder in step 2, add in thick paste, be uniformly mixed, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the invisible brightic honeyed pill for the treatment of of the present invention.

Medicine of the present invention has effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, YIN nourishing and the production of body fluid promoting, and determined curative effect, soon effective, short treating period, price is low, side effect is little, and the mode that this Chinese medicine preparation adopts treats the slight illness can removing invisible Patients with Glomerulonephritis, reduces the injury that Western medicine causes patient body, also mitigate family burden simultaneously, according to clinical 120 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 85%, two the total effective rate course for the treatment of 97.5%.

Detailed description of the invention

Embodiment one, Flos Lonicerae 10 parts, Fructus Forsythiae 13 parts, Periostracum Cicadae 3 parts, Herba Agrimoniae 25 parts, Rhizoma Imperatae 19 parts, Bombyx Batryticatus 4 parts, Radix Rehmanniae 10 parts, Cortex Moutan 10 parts, 10 parts, Poria, the Rhizoma Anemarrhenae 7 parts, Cortex Phellodendri 7 parts, Herba Taraxaci 15 parts, Herba Hedyotidis Diffusae 13 parts, Rhizoma Polygoni Cuspidati 13 parts, Radix Cirsii Japonici 10 parts, Herba Cirsii 10 parts, Herba Verbenae 10 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Herba Plantaginis 15 parts, Radix Puerariae 10 parts, Radix Salviae Miltiorrhizae 19 parts, Radix Glycyrrhizae 3 parts.

Embodiment two, Flos Lonicerae 15 parts, Fructus Forsythiae 18 parts, Periostracum Cicadae 6 parts, Herba Agrimoniae 30 parts, Rhizoma Imperatae 24 parts, Bombyx Batryticatus 9 parts, Radix Rehmanniae 15 parts, Cortex Moutan 15 parts, 15 parts, Poria, the Rhizoma Anemarrhenae 12 parts, Cortex Phellodendri 12 parts, Herba Taraxaci 20 parts, Herba Hedyotidis Diffusae 18 parts, Rhizoma Polygoni Cuspidati 18 parts, Radix Cirsii Japonici 15 parts, Herba Cirsii 15 parts, Herba Verbenae 15 parts, Radix Paeoniae Rubra 15 parts, the Radix Paeoniae Alba 15 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Herba Plantaginis 20 parts, Radix Puerariae 15 parts, Radix Salviae Miltiorrhizae 24 parts, Radix Glycyrrhizae 6 parts.

Embodiment three, Flos Lonicerae 20 parts, Fructus Forsythiae 23 parts, Periostracum Cicadae 9 parts, Herba Agrimoniae 35 parts, Rhizoma Imperatae 29 parts, Bombyx Batryticatus 14 parts, Radix Rehmanniae 20 parts, Cortex Moutan 20 parts, 20 parts, Poria, the Rhizoma Anemarrhenae 17 parts, Cortex Phellodendri 17 parts, Herba Taraxaci 25 parts, Herba Hedyotidis Diffusae 23 parts, Rhizoma Polygoni Cuspidati 23 parts, Radix Cirsii Japonici 20 parts, Herba Cirsii 20 parts, Herba Verbenae 20 parts, Radix Paeoniae Rubra 20 parts, the Radix Paeoniae Alba 20 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, Herba Plantaginis 25 parts, Radix Puerariae 20 parts, Radix Salviae Miltiorrhizae 29 parts, Radix Glycyrrhizae 9 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 120 example for medical treatment, wherein male 76 example, women 44 example, M-F 1.72:1,15 years old mean age, the course of disease time is not etc.Every basic documents such as patient age, sex, the course of disease are substantially identical.

Two, diagnostic criteria:

Draft according to " national primary glomerulopathy classification and treatment and diagnostic criteria symposium summary ":

1, lasting microscopic hematuria or repeatedly gross hematuria (urine erythrocyte: centrifugal microscopy >3/HP); 2, the mutually lopsided erythrocyte >80% in urine erythrocyte position;

3, without hypertension, edema, protein, renal hypofunction;

4, acute postinfectious glomerulonephritis, secondary glomerulonephritis, hereditary nephritis, lumbago-hematuria syndrome, features of idiopathic hypercalciuria and the athlete's nephritis etc. caused by motion is got rid of.

Three, Therapeutic Method:

According to Medications Example two of the present invention, and the pill that preferred preparation method is made, warm water takes, every day 3 times, each five, within 20 days, is a course for the treatment of.

Four, efficacy assessment standard:

1, cure: clinical symptoms all disappears, test chamber inspection is normal, centrifugal urine R-RBC <3/Hp, observes and has no repeatedly for three months.

2, effective: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.

3, invalid: clinical symptoms is without being clearly better or increasing the weight of.

Five, observation group's result statistics

According to statistical result showed, Chinese medicine of the present invention has good clinical effectiveness for the invisible glomerulonephritis for the treatment of, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, patient Wang, man, 18 years old, patient's readme checks out the urine erythrocyte positive when hospital haves a medical check-up, concrete reason is not quite clear, without frequent micturition, urgent micturition, dysurea phenomenon, there is lumbago at ordinary times, arthralgic phenomenon, through many examination in hospital, be diagnosed as invisible glomerulonephritis, slightly take a turn for the better after hospitalize, but patient did not adhere to treatment afterwards, do not have how long disease relapse, patient upon somebody's introduction, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after taking treatment a period of time, the state of an illness is taken a turn for the better, continue a course for the treatment of of use, patient's readme health is obviously taken a turn for the better, the symptom before produced all disappears, hospital is gone to check, every inspection is all normal, follow up a case by regular visits to and have no recurrence half a year, recovery from illness.

Case two, patient goes into business certain, man, 20 years old, patient checks out to suffer from invisible glomerulonephritis in a health check-up, take a turn for the better to some extent through the hospitalize state of an illness, but do not have how long Mild edema appears in patient body, often feel the symptom that waist is ached, on inspection, palindromia, patient upon somebody's introduction, adopt the made preparation of the embodiment of the present invention two, and selected preparation method, after taking a period of time, patient's readme health is taken a turn for the better, edema of the body, the transference cures such as the soreness of waist, continue to take a course for the treatment of, symptom disappears completely, remove examination in hospital, indices is all normal, follow up a case by regular visits to half a year, do not recur, recovery from illness.

Claims (4)

1. the invisible brightic Chinese medicine preparation for the treatment of, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Flos Lonicerae 10-20 part, Fructus Forsythiae 13-23 part, Periostracum Cicadae 3-9 part, Herba Agrimoniae 25-35 part, Rhizoma Imperatae 19-29 part, Bombyx Batryticatus 4-14 part, Radix Rehmanniae 10-20 part, Cortex Moutan 10-20 part, Poria 10-20 part, Rhizoma Anemarrhenae 7-17 part, Cortex Phellodendri 7-17 part, Herba Taraxaci 15-25 part, Herba Hedyotidis Diffusae 13-23 part, Rhizoma Polygoni Cuspidati 13-23 part, Radix Cirsii Japonici 10-20 part, Herba Cirsii 10-20 part, Herba Verbenae 10-20 part, Radix Paeoniae Rubra 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, Herba Plantaginis 15-25 part, Radix Puerariae 10-20 part, Radix Salviae Miltiorrhizae 19-29 part, Radix Glycyrrhizae 3-9 part.

2. the invisible brightic Chinese medicine preparation for the treatment of according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Flos Lonicerae 15 parts, Fructus Forsythiae 18 parts, Periostracum Cicadae 6 parts, Herba Agrimoniae 30 parts, Rhizoma Imperatae 24 parts, Bombyx Batryticatus 9 parts, Radix Rehmanniae 15 parts, Cortex Moutan 15 parts, 15 parts, Poria, the Rhizoma Anemarrhenae 12 parts, Cortex Phellodendri 12 parts, Herba Taraxaci 20 parts, Herba Hedyotidis Diffusae 18 parts, Rhizoma Polygoni Cuspidati 18 parts, Radix Cirsii Japonici 15 parts, Herba Cirsii 15 parts, Herba Verbenae 15 parts, Radix Paeoniae Rubra 15 parts, the Radix Paeoniae Alba 15 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Herba Plantaginis 20 parts, Radix Puerariae 15 parts, Radix Salviae Miltiorrhizae 24 parts, Radix Glycyrrhizae 6 parts.

3. the invisible brightic Chinese medicine preparation for the treatment of according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is pill.

4. treat a preparation method for invisible brightic Chinese medicine preparation, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, takes Fructus Forsythiae bundle and becomes medicated bag, be put in water and soak 30-40 minute, filters, for subsequent use, step 2: by weight proportion of the present invention, takes Poria and grinds, and crosses 180 mesh sieves, for subsequent use, step 3: by weight proportion of the present invention, take Rhizoma Imperatae, Radix Rehmanniae, Cortex Moutan, the Rhizoma Anemarrhenae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Radix Puerariae, Radix Salviae Miltiorrhizae is put into after marmite adds step one immersion and is remained cold water, exceed powder 3 centimetres, after being fried boiling with high heat, again with 40-50 minute at a simmer, filter, obtain filtrate, the water of 3 centimetres is added in residue medicinal residues, then Herba Agrimoniae is added, Bombyx Batryticatus, Herba Taraxaci, Herba Hedyotidis Diffusae, Radix Cirsii Japonici, Herba Cirsii, Herba Verbenae, Herba Plantaginis, Radix Glycyrrhizae and a kind of medicated bag of step, decoct 30 minutes, finally add Flos Lonicerae, Periostracum Cicadae decocts 10 minutes, filter, waste, merge twice filtrate, then concentrate and add ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, for subsequent use, step 4: the thick paste by gained concentration of liquid medicine in step 3 being relative density 1.15 ~ 1.20 under 75 DEG C of environment, by gained powder in step 2, add in thick paste, be uniformly mixed, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the invisible brightic honeyed pill for the treatment of of the present invention.