CN104825905A - Traditional Chinese medicine preparation for treating blood transfusion reaction and method for manufacturing traditional Chinese medicine preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating blood transfusion reaction. The traditional Chinese medicine preparation comprises snake slough, hibiscus syriacus bark, belvedere fruits, white-dappled snakes, garter snakes, cortex dictamni, starwort roots, cortex lycii, cynanchum atratum, hairyvein agrimony, lalang grass rhizome, smoked plums, schisandra chinensis, fried peach seeds, leonurus japonicus, Chinese trumpet creeper, earthworm, buffalo horns, tree peony bark, radix paeoniae rubra, dried rehmannia roots, salvia miltiorrhiza, fructus polygoni orientalis and raw licorice which are proportioned according to certain weight ratios. The traditional Chinese medicine preparation has the advantages that effects of clearing heat, expelling dampness and pathogenic wind, dredging collaterals, removing heat to cool the blood and benefiting qi for promoting production of fluid can be realized, and the blood transfusion reaction can be effectively treated by the traditional Chinese medicine preparation.

Description

A kind of Chinese medicine preparation for the treatment of transfusion reaction and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of transfusion reaction.The invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Transfusion reaction refers in transfusion procedure or after terminating, the untoward reaction produced because inputting blood or its goods or transfusion and infusion assemblies used.The symptom that transfusion reaction brings mainly contains: 1, anaphylaxis.Anaphylaxis comprises: urticaria, vasodilation, arthralgia, uncomfortable in chest, breathe hard, dyspnea, hypotensive shock.2, nonhemolytic febrific reaction.Namely shiver with cold in a short time or in transfusion procedure after blood transfusion, generate heat, heating person's body temperature can reach 38 DEG C ~ 41 DEG C, and Nausea and vomiting, erubescence all appear in patient, and reaction continues 1 ~ 2 hour, then perspires, brings down a fever.3, post-transfusion purpura.Morbidity in about 7 days all after transfusion, morbidity sharply, has obvious fear of cold, high heat, urticaria; Time have headache, chest pain, dyspnea.There are hemorrhage, skin petechiae and ecchymosis, gingiva bleeding gingival hemorrhage, epistaxis, the melena widely of different parts.4, graft versus host disease.Heating, erubescence, erythra, severe diarrhea, hepatosplenomegaly etc.5, transfusion hemachromatosis.There is cutaneous pigmentation, liver function injury, diabetes, arrhythmia, cardiac insufficiency, sexual hypofunction clinically.

Mostly being of current treatment transfusion reaction should be acute, as dexamethasone injection, epinephrine etc., although the symptom that these energy rapid recovery patients occur, but the symptoms such as picture purpura, non-hemolytic heating, hemachromatosis, Western medicine often brings very large side effect, brings certain injury to the health of patient.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation, this Chinese medicine preparation has instant effect for treatment transfusion reaction, evident in efficacy, cheap, the feature had no side effect.

Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment transfusion reaction.

Inventor is in clinical treatment practice for many years, observe the misery that transfusion reaction brings to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of transfusion reaction repeatedly, the present invention selects Periostracum Serpentis, Cortex Hibisci, the Fructus Kochiae, Agkistrodon, Zaocys, Cortex Dictamni, Radix Stellariae, Cortex Lycii, Radix Cynanchi Atrati, Herba Agrimoniae, Rhizoma Imperatae, Fructus Mume, Fructus Schisandrae Chinensis, Semen Persicae (parched), Herba Leonuri, Flos Campsis, Pheretima, Cornu Bubali, Cortex Moutan, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Polygoni Orientalis, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is heat clearing and damp drying, wind dispelling dredging collateral, clearing away heat and cooling blood, effect of supplementing QI for promoting the production of body fluid, thus effectively can treat transfusion reaction.

The effect of Chinese medicine of the present invention:

Wherein:

Periostracum Serpentis: for Colubridae animal Elaphe taeniurus Cope Elaphe taeniura Cope, rat snake Elaphe carinata (Guenther) or Zaocys Zaocys dhumnades (Cantor) etc. slough off under dry epidermis film.Nature and flavor: salty, sweet are flat.Return Liver Channel.Effect: dispel the wind, arresting convulsion, removing toxic substances, nebula removing.For infantile convulsion, tic spasm, cataracta, sore throat, furuncle swells, skin pruritus.Pharmaceutical research is to the inhibitory action of erythrocyte thermosol blood: the inhibitory action of extracting solution 4mg and 12mg is respectively 20.5%(P < 0.01) and 48%(P < 0.01); Be equivalent to IDM1mg, Phenylbutazone 5mg is to the inhibitory action of haemolysis.Periostracum Serpentis also has the effect of obvious anti-inflammatory.

Cortex Hibisci: be peel of stem or the root bark of Malvaceae Hibiscus plant Hibiscus syriacus L. Hibiscus syriacus L..Nature and flavor: sweet, tepor.Enter large intestine, liver, spleen channel.Effect: clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.For dysentery, leucorrhea; Eczema scrotum tinea corporis is controlled in external, tinea pedis." medical center bun is wanted ": tonifying the lung eliminating dampness by diuresis, reduces phlegm and internal heat, tranquilizing mind, easing joint movement.Control lung abscess, acute appendicitis, epistaxis, quench one's thirst, dysphoria and insomnia.

The Fructus Kochiae: be the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Nature and flavor: pungent, bitter, cold.Return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.

Agkistrodon: Agkistrodon Agkistrodonacutus(Gunther) the dry corpse of snakelet.Nature and flavor: sweet, salty, temperature; Poisonous.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.To the disease such as rheumatic arthralgia, spasm of muscles and vessels, can the medicine such as Pei Wu Herba Siegesbeckiae, Radix Angelicae Pubescentis, Radix Clematidis with using; Control deviation of the eye and mouth, aphasia, or the disease such as muscle arteries and veins contraction urgency, muscular paralysis, can apply with the compatibility such as Scorpio, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, or infusing drugs in wine clothes.Control tetanus, spasm is twitched and infantile convulsion convulsion is fainted, and the medicines such as compatibility Zaocys, Scolopendra are with using.In addition, Agkistrodon again Ke Yu Ma is crazy, and scabies has the effect of the counteracting toxic substances that dispels the wind, can with the medicine such as Zaocys, Realgar with using.

Zaocys: be the dry body of Colubridae animal Zaocys Zaocys dhumnades (Cantor).Nature and flavor: sweet are flat.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.

Cortex Dictamni: the root bark being Rutaceae herbaceos perennial shaggy-fruited dittany Dictamnus dasycarpus Turcz..Nature and flavor: bitter, salty, cold.Return spleen, lung, small intestinal, stomach, urinary bladder channel.Function: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances." property of medicine opinion ": " control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy Huang, labor are yellow." modern pharmacology research; Cortex Dictamni has antibacterial action: the infusion of in vitro tests 1:4 to multiple pathomycete as trichophyton, Trichophyton concentricunm, oidium schoenleinii; all have inhibitory action in various degree, but have the ether of report this product, ethanol and water extract to be showed no effect to the coccuses such as golden yellow, escherichia coli bacillus pyocyaneus and Mycobacterium phlei.

Radix Stellariae: be the dry root of Caryophyllaceae Stellaria plant Radix Stellariae Stellaria dichotoma L. var.lanceolata Bge..Nature and flavor: sweet, be slightly cold.Return liver, stomach warp.Effect: clearind deficient heat, dispelling fever with infantile malnutrition.For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, children's's infantile malnutrition with fever.The sweet cold tonifying YIN of these product, clearing away heat and cooling blood, brings down a fever and not bitterly to let out, the cloudy and not ascension of reason, and for reducing the asthenic fever is except the common medicine of hectic fever due to YIN-deficiency, normal medicine is same with Herba Artemisiae Annuae, Cortex Lycii, Carapax Trionycis etc. uses.Radix Stellariae not only has the effect of heat clearing away, also has the effect of removing heat from blood concurrently.

Cortex Lycii: be the dry root bark of matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarum L..Nature and flavor: sweet, cold.Return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Record in " book on Chinese herbal medicine is stated ": cure mainly deficient fever, alternate attacks of chills and fever, allly see blood disorder, epistaxis, cough blood, cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine.

Radix Cynanchi Atrati: be asclepiadaceae plant Radix Cynanchi Atrati Cynanchum atratum Bge.Or Cynanchum versicolor Bunge Cynanchum versicolor Bge.Dry root and rhizome.Nature and flavor: bitter, salty, cold.Return stomach, liver, kidney channel.Effect: clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.This product bitter cold, be apt to, into blood system, have clearing away heat and cooling blood, the merit of tonifying YIN heat extraction, can excess-heat clearly, again can reducing the asthenic fever, be used for the treatment of warm febrile disease and join the army blood, high hot excessive thirst, coma crimson tongue, often to use together with Radix Rehmanniae, Herba Artemisiae Annuae, Cortex Lycii.

Herba Agrimoniae: be the aerial parts of Rosaceae herbaceos perennial Agrimony Agrimonia pilosa Ledeb..Nature and flavor: bitter, puckery, flat.GUIXIN, Liver Channel.Effect: astringing to arrest bleeding, removing toxic substances, dysentery relieving, parasite killing cuts cruel.For hemoptysis, spit blood, control epistaxis and have specially good effect, malaria, de-power impairment caused by overstrain, carbuncle.This product puckery convergence and property is put down, no matter the going out blood disorder and all can apply of cold and heat and asthenia and sthenia.Treatment heat in blood is hemorrhage normal to be used together with Radix Rehmanniae, Cortex Moutan.

Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.Dysuria, due to interior-heat also, pyrolysis then just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach is explained by oneself, and body fluid is raw and yearningly also stop.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, and removing heat from blood and blood, then collapse spontaneous recovery.Heat in blood is absurd row then, overflow upper orifices for telling, for coughing up, be epistaxis, bleeding from the gum, removing heat from blood and blood, then all cards are from removing.Strengthening the spleen invigorating middle warmer, diuresis, therefore swollen jaundice of also harnessing the river, and hold concurrently reason typhoid fever hiccup also.

Fructus Mume: be the dry almost ripe fruit of rose department plant plum Prunus mume (Sieh.) Sieb .et Zucc..Nature and flavor: sweet, sour, puckery, warm.Return stomach, large intestine channel.Effect: relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.This product is used for not closing up for a long time after carbuncle sore is burst, and external has the effect of removing dampness expelling pus and promoting granulation." Bencao Jingshu ": Fructus Mume, namely the Fructus Mume of the present is also, the sourest." warp " is said: heat impairing vital QI, and evil visitor is in the heart, then gas superinverse and stuffy sensation with restlessness, the heart is uneasy for it.Fructus Mume sour in the mouth, can hold back superficial heat, air-breathing can return unit, therefore the main therapeutic method to keep the adverse QI flowing downwards, heat extraction stuffy sensation with restlessness and feeling at ease also.Dysentery person, large intestine collapse is also; Good saliva xerostomia person, hyperactivity of deficient fire, deficiency of body fluid is also; Acid can hold back asthenic fire, change body fluid, solid intestinal take off, so lead also.Its main limb pain, hemiplegia meciless person, covers because dampness is dipped in meridians, then muscle arteries and veins relaxes vertical, or pain is meciless; Liver governing tendons, sour in taste acting on the liver and nourishing muscle and tendon, liver obtain support, then solid skeleton and pliable tendons, machine-operated tonneau and front card removes.

Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Semen Persicae (parched): be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.The power of Semen Persicae blood stasis dispelling is comparatively strong, also known as stasis-breaking drug, is used for the treatment of blood stasis, WEIJIA, often joins Flos Carthami, Radix Angelicae Sinensis.Semen Persicae is improved effect to blood flow retardance, blood obstacle, and each internal organs can be made respectively to organize functional recovery normal.

Herba Leonuri: for Labiatae is annual or the herb of 2 years raw herbaceous plant Herba Leonuri Leonurus heterophyllus Sweet..Nature and flavor: bitter, pungent, are slightly cold.Return liver, pericardium channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.This product hardship is let out pungent loose, and master enters blood system, is good at blood circulation promoting and blood stasis dispelling regulating menstruation, flaccidity gynecological multiparity key medicine.

Flos Campsis: for reaching the clouds the dried floral of Campsis radicans (L.) Seem. and root in reach the clouds Campsis grandiflora (Thunb.) K. Schum. or America of bavin Wei section plant.Nature and flavor: flower: sweet, sour, cold.Flower: return liver, pericardium channel.Effect: removing heat from blood, blood stasis dispelling, dispels the wind.For menoxenia, Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.

Pheretima: be the dry body of Ju Yin section animal Pheretima aspergillum Pheretima aspergillum (E. Perrier), popular Pheretimatschiliensis Pheretima vulgaris Chen, power simulation Pheretima guillelmi (Michaelsen) or comb blind Pheretimatschiliensis Pheretima pect inifera Michaelsen.Nature and flavor: salty, cold.Return liver, spleen, urinary bladder channel.Effect: heat clearing away is calmed the frightened, dredge the meridian passage, clearing heat and relieving dyspnea, relieving stranguria by diuresis.This product is longer than removing obstruction in the collateral to relieve pain, is applicable to blockage of meridian that many reasons causes, blood vessels are smooth, the disease that podomere is unfavorable.

Cornu Bubali: be the angle of bovid Babalus bubalis L. Bubalus bubalis Linnaeus.Nature and flavor: bitter, cold.GUIXIN, Liver Channel.Effect: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For the high heat of epidemic febrile disease, unconsciousness and delirium, sends out speckle dermexanthesis, hematemesis and epistaxis, infantile convulsion, demented.

Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter, cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.For the disease such as sore and toxic, acute appendicitis, this product is also conventional medicine.Treating carbuncle sore can coordinate heat and toxic materials clearing away medicine as Fructus Forsythiae, Herba Violae and so on; Controlling acute appendicitis can use equivalent with Radix Et Rhizoma Rhei from the beginning of failing pus person.This product with eliminating carbuncle, can be used for acute appendicitis and carbuncle sore tumefacting virus by clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, and the acute appendicitis initial stage can compatibility Radix Et Rhizoma Rhei, also can join the resolving heat and reducing pathogenic fire such as Flos Lonicerae, Fructus Forsythiae.

Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor: bitter, are slightly cold.Return Liver Channel.Effect: eliminating stasis to stop pain, clearing away heat and cooling blood, detumescence.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.This product hardship is fallen, and has effect of promoting blood circulation to restore menstrual flow, loose Yu Xiao wei, row stagnation pain.Often join Cortex Moutan.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, this product bitter cold, main enter Liver Channel, be apt to away blood system, can clearing away liver-fire, except blood system is hot and suffocating and have the merit of removing heat from blood, hemostasis, dissipating blood stasis speckle removing.Cortex Moutan and Radix Paeoniae Rubra is energy clearing away heat and cooling blood all, and blood circulation promoting and blood stasis dispelling, enters blood system with controlling epidemic febrile disease.The power of Cortex Moutan removing heat from blood is comparatively strong, and can purify the blood a point excess-heat, can control fever due to yin deficiency again, and the merit that Radix Paeoniae Rubra is invigorated blood circulation comparatively wins, the kind pain disease controlled caused by congestion.

Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Nature and flavor: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Can be used for Tianjin wound thirsty, interior-heat is quenched one's thirst.This product is sweet cold, can among heat clearing away YIN nourishing and the production of body fluid promoting, cold in nature and enter blood system, can not only the heat of clearing heat in YING system blood system and removing heat from blood, and sweet in the mouth is cold in nature can promote the production of body fluid, and has the effect of nourishing YIN and clearing away heat.Research shows: the existing anastalsis of Radix Rehmanniae, has blood coagulation resisting function again, and the yellow needles of Radix Rehmanniae ethanol extraction gained can shorten rabbit clotting time.

Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.Containing cryptotanshinone, dihydrotanshinone in red sage formulation, there is inhibitory action to external staphylococcus, escherichia coli, degeneration bacillus.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, to the hypertrophy eliminating hepatic fibrosis connective tissue, also may have certain effect.Modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment, is the natural Chinese medicine that a kind of safety treats again thrombus disease reliably.

Fructus Polygoni Orientalis: be the dry mature fruit of polygonaceae plant smartweed Polygonum orientale L..Nature and flavor: salty, cold.Return liver, stomach, spleen three warp.Function: repercussive removing mass, invigorating spleen to remove dampness.Control flank disease amassing, dropsy, has a stomach-ache, lack of appetite abdominal distention, acute catarrhal conjunctivitis, and skin ulcer swells, scrofula.

Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: Periostracum Serpentis expelling wind for relieving convulsion, removing toxic substances nebula removing in side, Cortex Hibisci, Fructus Kochiae clearing away heat-damp and promoting diuresis, Agkistrodon, Zaocys dispelling wind and removing obstruction in the collateral, Cortex Dictamni heat clearing and damp drying, dispelling wind for relieving itching, above Six-element is monarch drug altogether, first start with from the clinical symptoms of disease, the symptoms such as rapid effective reduction of patient heating, edema, spasm, the matter of great urgency of reduction of patient.Radix Stellariae clearind deficient heat, dispelling fever with infantile malnutrition, Cortex Lycii, Radix Cynanchi Atrati removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing, Herba Agrimoniae astringing to arrest bleeding, imperata rhizome heat-clearing diuretic, Fructus Mume astringing to arrest bleeding, expelling pus and promoting granulation, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, kidney calming, above seven tastes are ministerial drug altogether, while increasing monarch drug drug effect, also there is heat clearing away except infantile malnutrition, Linkage's granulation promoting, the effect of supplementing QI for promoting the production of body fluid, patients with transfusion can be eliminated and react the purpura caused, heating, epistaxis, the different parts such as gingival hemorrhage are hemorrhage, thus reach the object of disease therapy, a few taste also has effect of kidney calming above, be conducive to the body constitution strengthening patient, thus accelerate the recovery of patient.Semen Persicae (parched) blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, Herba Leonuri inducing diuresis to remove edema, Flos Campsis cooling blood and dissolving stasis, Pheretima heat clearing away arresting convulsion, dredge the meridian passage, Cornu Bubali heat-clearing and toxic substances removing, Cortex Moutan, Radix Paeoniae Rubra eliminating stasis to stop pain, clearing away heat and cooling blood, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, Radix Salviae Miltiorrhizae clears away heart-fire relieving restlessness, nourishing blood to tranquillize the mind, Fructus Polygoni Orientalis repercussive removing mass, and above a few taste is adjuvant drug altogether, strengthen curative effect of medication, there is effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, the relieving restlessness that clears away heart-fire simultaneously, make patient heart happy, be conducive to the disappearance of symptom.Radix Glycyrrhizae priming is returned through, coordinating the actions of various ingredients in a prescription, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of heat clearing and damp drying, wind dispelling dredging collateral, clearing away heat and cooling blood, supplementing QI for promoting the production of body fluid, effectively can treat transfusion reaction.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Periostracum Serpentis 3-9 part, Cortex Hibisci 7-17 part, Fructus Kochiae 13-23 part, Agkistrodon 7-17 part, Zaocys 7-17 part, Cortex Dictamni 7-17 part, Radix Stellariae 10-20 part, Cortex Lycii 13-23 part, Radix Cynanchi Atrati 7-17 part, Herba Agrimoniae 25-35 part, Rhizoma Imperatae 25-35 part, Fructus Mume 19-29 part, Fructus Schisandrae Chinensis 7-17 part, Semen Persicae (parched) 7-17 part, Herba Leonuri 13-23 part, Flos Campsis 4-14 part, Pheretima 4-14 part, Cornu Bubali 13-23 part, Cortex Moutan 10-20 part, Radix Paeoniae Rubra 7-17 part, Radix Rehmanniae 19-29 part, Radix Salviae Miltiorrhizae 19-29 part, Fructus Polygoni Orientalis 10-20 part, Radix Glycyrrhizae 3-9 part.

Wherein be preferably: Periostracum Serpentis 6 parts, Cortex Hibisci 12 parts, the Fructus Kochiae 18 parts, Agkistrodon 12 parts, Zaocys 12 parts, Cortex Dictamni 12 parts, Radix Stellariae 15 parts, Cortex Lycii 18 parts, Radix Cynanchi Atrati 12 parts, Herba Agrimoniae 30 parts, Rhizoma Imperatae 30 parts, Fructus Mume 24 parts, Fructus Schisandrae Chinensis 12 parts, Semen Persicae (parched) 12 parts, Herba Leonuri 18 parts, Flos Campsis 9 parts, Pheretima 9 parts, Cornu Bubali 18 parts, Cortex Moutan 15 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae 24 parts, Radix Salviae Miltiorrhizae 24 parts, Fructus Polygoni Orientalis 15 parts, Radix Glycyrrhizae 6 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is granule, and its preparation method is as follows:

Step one: by weight proportion of the present invention, first becomes medicated bag by the Fructus Kochiae, Fructus Schisandrae Chinensis bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;

Step 2: by weight proportion of the present invention, grinds to 180 mesh sieves by Semen Persicae (parched), Cornu Bubali, for subsequent use;

Step 3: by weight proportion of the present invention, by Cortex Hibisci, Cortex Dictamni, Radix Stellariae, Cortex Lycii, Radix Cynanchi Atrati, Rhizoma Imperatae, Cortex Moutan, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Salviae Miltiorrhizae is put into after marmite adds step one immersion and is remained cold water, exceed powder 3 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Herba Agrimoniae is added, Fructus Mume, Herba Leonuri, medicated bag in Fructus Polygoni Orientalis and step one decocts about 30 minutes, add Periostracum Serpentis afterwards, Agkistrodon, Zaocys, Flos Campsis, Pheretima, Radix Glycyrrhizae decocts filtration in 20 minutes, obtain filtrate, merge twice filtrate, waste, and when filtrate being concentrated into about 80 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment, for subsequent use,

Step 4: step 2 gained fine powder adds in step 3 gained thick paste and is uniformly mixed, dry, be ground into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 10g/ bag, every bag of granule containing crude drug 5g.

The effects such as medicine heat clearing and damp drying of the present invention, wind dispelling dredging collateral, clearing away heat and cooling blood, supplementing QI for promoting the production of body fluid, and instant effect, evident in efficacy, cheap, have no side effect, add up according to clinical 248 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 90.3%, two the total effective rate course for the treatment of 97.6%.

Detailed description of the invention

Embodiment one, Periostracum Serpentis 3 parts, Cortex Hibisci 7 parts, the Fructus Kochiae 13 parts, Agkistrodon 7 parts, Zaocys 7 parts, Cortex Dictamni 7 parts, Radix Stellariae 10 parts, Cortex Lycii 13 parts, Radix Cynanchi Atrati 7 parts, Herba Agrimoniae 25 parts, Rhizoma Imperatae 25 parts, Fructus Mume 19 parts, Fructus Schisandrae Chinensis 7 parts, Semen Persicae (parched) 7 parts, Herba Leonuri 13 parts, Flos Campsis 4 parts, Pheretima 4 parts, Cornu Bubali 13 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 7 parts, Radix Rehmanniae 19 parts, Radix Salviae Miltiorrhizae 19 parts, Fructus Polygoni Orientalis 10 parts, Radix Glycyrrhizae 3 parts.

Embodiment two, Periostracum Serpentis 6 parts, Cortex Hibisci 12 parts, the Fructus Kochiae 18 parts, Agkistrodon 12 parts, Zaocys 12 parts, Cortex Dictamni 12 parts, Radix Stellariae 15 parts, Cortex Lycii 18 parts, Radix Cynanchi Atrati 12 parts, Herba Agrimoniae 30 parts, Rhizoma Imperatae 30 parts, Fructus Mume 24 parts, Fructus Schisandrae Chinensis 12 parts, Semen Persicae (parched) 12 parts, Herba Leonuri 18 parts, Flos Campsis 9 parts, Pheretima 9 parts, Cornu Bubali 18 parts, Cortex Moutan 15 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae 24 parts, Radix Salviae Miltiorrhizae 24 parts, Fructus Polygoni Orientalis 15 parts, Radix Glycyrrhizae 6 parts.

Embodiment three, Periostracum Serpentis 9 parts, Cortex Hibisci 17 parts, the Fructus Kochiae 23 parts, Agkistrodon 17 parts, Zaocys 17 parts, Cortex Dictamni 17 parts, Radix Stellariae 20 parts, Cortex Lycii 23 parts, Radix Cynanchi Atrati 17 parts, Herba Agrimoniae 35 parts, Rhizoma Imperatae 35 parts, Fructus Mume 29 parts, Fructus Schisandrae Chinensis 17 parts, Semen Persicae (parched) 17 parts, Herba Leonuri 23 parts, Flos Campsis 14 parts, Pheretima 14 parts, Babalus bubalis L.-23 parts, Cortex Moutan 20 parts, Radix Paeoniae Rubra 17 parts, Radix Rehmanniae 29 parts, Radix Salviae Miltiorrhizae 29 parts, Fructus Polygoni Orientalis 20 parts, Radix Glycyrrhizae 9 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 248 example for medical treatment.Wherein male 118 example, women 130 example, M-F 1:1.1, max age 79 years old, minimal ages 18 years old.

Two, Therapeutic Method:

According to Medications Example two of the present invention, and the granule that preferred preparation method is made, boiled water is taken after mixing it with water, every day 3 times, each one bag, within 3 days, is a course for the treatment of.

Three, efficacy assessment standard

1, cure: transfusion reaction and related symptoms all disappear, and do not affect activity and work, do not occur any sequela.

2, take a turn for the better: transfusion reaction and associated clinical symptoms disappear substantially, after treatment, symptom obviously alleviates, and does not affect daily life and work.

3, do not heal: transfusion reaction clinical symptoms even increases the weight of without any improvement.

Four, therapeutic outcome statistics

Wherein: total effective rate=cure rate+improvement rate

Shown by the statistics of therapeutic outcome, Chinese medicine of the present invention has good clinical effectiveness in treatment transfusion reaction, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, poplar, female, 34 years old, patient is in way home, accidentally suffer a car accident, promptly be sent to hospital, due to patient's severe loss of blood, need urgent blood transfusion, patient is in the process of input the 3rd bag of blood, suddenly there is rapid breathing, purpura, the phenomenons such as heating, nurse stops blood transfusion to patient immediately, patients symptomatic alleviates to some extent, because patient body also needs to continue blood transfusion, hospital adopts approximate blood source, through the treatment of hospital, patient has departed from life danger, but the transfusion reaction that patient occurs is thrown away and is not eased, patient adopts made granule in the embodiment of the present invention two, after patient takes two courses for the treatment of, heating, the phenomenons such as erythra disappear completely, there are not other complication, recovery from illness.

Case two, Wang, man, 18 years old, patient is cause transfusion reaction in hospital's blood transfusion, there is the symptoms such as high fever, purpura, allergic rash in patient, although patient discharge, these complication have had a strong impact on the life of patient, made granule in the rear employing embodiment of the present invention two, after patient takes two courses for the treatment of, sensory symptoms obviously alleviates, and hyperpyrexia, erythra phenomenon take a turn for the better gradually, and patient continues to take a course for the treatment of, patient body symptom is significantly taken a turn for the better, go examination in hospital blood situation normal, do not occur other complication, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation of transfusion reaction for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Periostracum Serpentis 3-9 part, Cortex Hibisci 7-17 part, Fructus Kochiae 13-23 part, Agkistrodon 7-17 part, Zaocys 7-17 part, Cortex Dictamni 7-17 part, Radix Stellariae 10-20 part, Cortex Lycii 13-23 part, Radix Cynanchi Atrati 7-17 part, Herba Agrimoniae 25-35 part, Rhizoma Imperatae 25-35 part, Fructus Mume 19-29 part, Fructus Schisandrae Chinensis 7-17 part, Semen Persicae (parched) 7-17 part, Herba Leonuri 13-23 part, Flos Campsis 4-14 part, Pheretima 4-14 part, Cornu Bubali 13-23 part, Cortex Moutan 10-20 part, Radix Paeoniae Rubra 7-17 part, Radix Rehmanniae 19-29 part, Radix Salviae Miltiorrhizae 19-29 part, Fructus Polygoni Orientalis 10-20 part, Radix Glycyrrhizae 3-9 part.

2. the Chinese medicine preparation of the treatment transfusion reaction according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Periostracum Serpentis 6 parts, Cortex Hibisci 12 parts, the Fructus Kochiae 18 parts, Agkistrodon 12 parts, Zaocys 12 parts, Cortex Dictamni 12 parts, Radix Stellariae 15 parts, Cortex Lycii 18 parts, Radix Cynanchi Atrati 12 parts, Herba Agrimoniae 30 parts, Rhizoma Imperatae 30 parts, Fructus Mume 24 parts, Fructus Schisandrae Chinensis 12 parts, Semen Persicae (parched) 12 parts, Herba Leonuri 18 parts, Flos Campsis 9 parts, Pheretima 9 parts, Cornu Bubali 18 parts, Cortex Moutan 15 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae 24 parts, Radix Salviae Miltiorrhizae 24 parts, Fructus Polygoni Orientalis 15 parts, Radix Glycyrrhizae 6 parts.

3. the Chinese medicine preparation for the treatment of transfusion reaction according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is granule.

4. treat a preparation method for the Chinese medicine preparation of transfusion reaction, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first the Fructus Kochiae, Fructus Schisandrae Chinensis bundle is become medicated bag, is put in water and soaks about 45 minutes, filters, for subsequent use, step 2: by weight proportion of the present invention, grinds to 180 mesh sieves by Semen Persicae (parched), Cornu Bubali, for subsequent use, step 3: by weight proportion of the present invention, by Cortex Hibisci, Cortex Dictamni, Radix Stellariae, Cortex Lycii, Radix Cynanchi Atrati, Rhizoma Imperatae, Cortex Moutan, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Salviae Miltiorrhizae is put into after marmite adds step one immersion and is remained cold water, exceed powder 3 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Herba Agrimoniae is added, Fructus Mume, Herba Leonuri, medicated bag in Fructus Polygoni Orientalis and step one decocts about 30 minutes, add Periostracum Serpentis afterwards, Agkistrodon, Zaocys, Flos Campsis, Pheretima, Radix Glycyrrhizae decocts filtration in 20 minutes, obtain filtrate, merge twice filtrate, waste, and when filtrate being concentrated into about 80 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment, for subsequent use, step 4: step 2 gained fine powder adds in step 3 gained thick paste and is uniformly mixed, dry, be ground into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 10g/ bag, every bag of granule containing crude drug 5g.