CN104887866A - Traditional Chinese medicine for treating gout - Google Patents
Traditional Chinese medicine for treating gout Download PDFInfo
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- CN104887866A CN104887866A CN201510380991.5A CN201510380991A CN104887866A CN 104887866 A CN104887866 A CN 104887866A CN 201510380991 A CN201510380991 A CN 201510380991A CN 104887866 A CN104887866 A CN 104887866A
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Abstract
The invention discloses a traditional Chinese medicine for treating gout. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 12-16 parts of jasmines, 8-17 parts of clematis, 9-19 parts of scented daphne leaves, 8-13 parts of common red fox meat, 7-12 parts of beautiful sweetgum fruits, 11-15 parts of orange jessamine roots, 6-12 parts of polyporus umbellatus, 11-16 parts of needle juniper, 9-13 parts of folium callicarpae pedunculalae, 9-17 parts of Chinese starjasmine stems, 12-15 parts of indian damnacanthus herb, 7-15 parts of photinia serrulata, 6-10 parts of semen strychni, 7-11 parts of ligusticum and 10-16 parts of curculigo capitulata. The traditional Chinese medicine further has the excellent effects of promoting blood circulation to remove blood stasis and inducing diuresis to alleviate edema, relaxing spasm and relieving pains, and tonifying kidney and nourishing liver. The selected materials are traditional Chinese medicine materials, and are free of any toxic or side effects. The materials are combined for use, so that the traditional Chinese medicine has the characteristics of being exact in curative effect, safe and convenient and low in price.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicinal formulae for the treatment of gout.
Background technology
Gout is because purine metabolic disturbance, blood uric acid increase, and causes uric acid crystal to be deposited on joint and subcutaneous tissue and a kind of disease caused.Clinically with hyperuricemia, characteristic acute joint, scorching recurrent exerbation, gout calculus for feature, severe patient is stung and is caused joint deformity and dysfunction, acute obstructive nephropathy or gouty nephropathy.In recent years, the incidence rate of gout and hyperuricemia is in rising trend, and age of onset presents and becomes younger.General outbreak position is thumb joint, ankle joint, knee joint etc.Long-term patient with gout has and shows effect in finger-joint, and even auricle is containing the case of soft tissue portion.Gouty attack,acute position occur red, swollen, hot, have an intense pain, much more general to show effect midnight, people can be made to wake up with a start from sleep.At the gout initial stage, lower limb are more common in outbreak.Constitutional and the large class of Secondary cases two can be divided into according to cause of disease difference.Primary gout refers on the basis getting rid of other diseases, caused by congenital purine metabolic disturbance and (or) uric acid excretion disorder; Secondary gout refers to be secondary to uricopoiesis caused by underexcretion, myeloproliferative disease and chemotherapy of tumors caused by kidney disease or some drugs to be increased.
Gout belongs to Chinese medical ' arthralgia syndrome ' category, with arthralgia aggravated by cold and damp-heat arthralgia common.Chinese medicine thinks that the cause of disease of primary disease is addicted to food greasy and surfeit flavour, the heresy invasion and attack body making heat of wetting, retention of damp-heat in the interior, affection of exogenous wind-cold, numbness resistance muscle arteries and veins, muscle, joint, causes to seek _ defend to go puckery, and blockage of main and collateral channels, then pain, swelling occur, or limb activity is unfavorable.Or natural endowment is not enough, or aged debility, deficiency-weakness of spleen-QI, dysfunction of the spleen in transportation, kidney flatus, folding mistake department, can not separating clear and excreting turbid, and damp and hot interior life, accumulates heat-transformation of a specified duration, and poly-expectorant stays the stasis of blood, causes the winddamp phlegm stasis of blood, and numbness hinders meridians.Gout etiology and pathogenesis is different in its different developmental stage, and according to the difference of clinical manifestation, each doctor is many is divided into acute period of expansion and chronic remission stage by primary disease.Stage of attack, based on the domination of pathogen, multiplex clearing away heat-damp and promoting diuresis, changes turbid dredging collateral method for the treatment of; Catabasis, based on weakened body resistance, adopts the method for invigorating the liver and kidney, QI and blood regulating more, takes into account eliminating evil.The friendly equality of king adds Herba Lysimachiae, Spora Lygodii, Sargassum, Pseudobulbus cremastrae seu pleiones, Nidus Vespae etc. on the basis of clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, to let out turbid removing toxic substances, phlegm-stasis blocking collateral type patient with gout is treated in resolving phlegm and softening hard masses ruling by law, its cure rate higher than colchicine group, and can obviously reduce the complication such as hyperuricemia, hyperlipemia.
Application publication number CN103989992A(application number 201410205116.9) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of gout, be made up of the raw material of following parts by weight: Flos Lonicerae 25-35 part, Ramulus Mori 25-35 part, Stigma Maydis 15-25 part, Semen Plantaginis 15-25 part, Herba Hedyotidis Diffusae 15-25 part, Radix Isatidis 15-25 part, Herba Houttuyniae 10-20 part, Poria 10-20 part, Radix Rauvolfiae 5-15 part, Scolopendra 5 parts.Application publication number CN103007061A(application number 201210515957.0) Chinese invention patent document disclose a kind of pill for the treatment of gout, be made up of according to parts by weight following component: Radix Aconiti Preparata 8-12 part, Rhizoma Acori Graminei 3-7 part, Semen Strychni 2-6 part, Stigma Croci sativi 2-12 part, Cortex Phellodendri 6-8 part, Caulis Akebiae 7-10 part, Radix Angelicae Dahuricae 5-6 part, Olibanum 3-8 part, Myrrha 6-8 part, Radix Angelicae Pubescentis 8-10 part, Rhizoma Gastrodiae 6-8 part, Rhizoma Atractylodis 7-12 part, Pericarpium Citri Reticulatae 3-8 part, Radix Platycodonis 2-8 part.Application publication number CN103479928A(application number 201210196938.6) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of gout, be made up of the raw material of following weight grams: Rhizoma Dioscoreae 28-32 gram, Semen Coicis 18-22 gram, Herba Ephedrae 4-8 gram, Semen Sojae Preparatum 28-32 gram, Rhizoma Chuanxiong, Rhizoma Atractylodis, Rhizoma Et Radix Notopterygii, each 8-12 gram of Radix Saposhnikoviae, Radix Angelicae Sinensis 13-17 gram.
The medicine of current treatment gout is that primary and secondary effect is comparatively large with Western medicine, and long-term prescription, not only easily causes patient body to produce untoward reaction, can also form dependency to medicine.Treatment by Chinese herbs gout, on the basis using differentiation of tcm, makes full use of the pharmacological achievement in research of modern Chinese medicine simultaneously, substantially increases curative effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare the Chinese medicinal formulae simply, conveniently taking, treat safely and effectively gout.This Chinese medicinal formulae determined curative effect is convenient to Clinical practice.
Technical scheme of the present invention is:
The Chinese medicinal formulae for the treatment of gout, is prepared from by following bulk drugs, is weight portion: Fructus Gardeniae 12-16; Radix clematidis floridae 8-17; Folium daphnes odorae 9-19; Carnis Vulpes 8-13; Fructus Liquidambaris 7-12; Radix Murrayae 11-15; Polyporus 6-12; Juniperus rigida Sieb.et Zucc. 11-16; Folium Callicarpae Formosanae 9-13; Caulis Trachelospermi 9-17; Herba Damnacanthi 12-15; Chinese photinia 7-15; Semen Strychni 6-10; Rhizoma Ligustici 7-11; great Ye Rhizoma Curculiginis 10-16.
In preferred scheme, Fructus Gardeniae 13-15; Radix clematidis floridae 11-14; Folium daphnes odorae 12-16; Carnis Vulpes 9.5-11.5; Fructus Liquidambaris 8.5-10.5; Radix Murrayae 12-14; Polyporus 8-10; Juniperus rigida Sieb.et Zucc. 12.5-14.5; Folium Callicarpae Formosanae 10-12; Caulis Trachelospermi 11-15; Herba Damnacanthi 13-14; Chinese photinia 9.5-12.5; Semen Strychni 7-9; Rhizoma Ligustici 8-10; great Ye Rhizoma Curculiginis 12-14.
Be more preferably, Fructus Gardeniae 14; Radix clematidis floridae 12.5; Folium daphnes odorae 14; Carnis Vulpes 10.5; Fructus Liquidambaris 9.5; Radix Murrayae 13; Polyporus 9; Juniperus rigida Sieb.et Zucc. 13.5; Folium Callicarpae Formosanae 11; Caulis Trachelospermi 13; Herba Damnacanthi 13.5; Chinese photinia 11; Semen Strychni 8; Rhizoma Ligustici 9; great Ye Rhizoma Curculiginis 13.
The Chinese medicinal formulae for the treatment of gout, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Carnis Vulpes is cleaned, cut fritter, add Chinese liquor and mix thoroughly, pickle 20-30 minute (preferably pickling 25 minutes), be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turns little fire and decocts 1-1.5 hour (preferably turning little fire to decoct 1.3 hours), fleshing gets decoction, filter, being evaporated to 80 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(2) Fructus Gardeniae is pounded fragment, adds Sucus Zingberis and mixes thoroughly (Fructus Gardeniae: Rhizoma Zingiberis=10:3), and vexed 10-25 minute (preferably vexed 18 minutes), put in parch container, and slow fire adds to propagandize hotly to Sucus Zingberis and exhausted completely, takes out, cools, porphyrize, for subsequent use; Semen Strychni and 12% yellow wine mix thoroughly, stew to moisten to wine to the greatest extent, put in parch, slow fire fry to golden yellow be degree, take out, cool, porphyrize, for subsequent use;
(3) by fully dry for the crude drug except step (1) and (2), be ground into fine powder, gained raw material medicated powder is placed in percolator, with second alcohol and water for solvent, carry out percolation according to percolation, percolate to be collected is 17-21 doubly (percolate preferably to be collected is 19 times of raw material medicated powder amount) stopping percolation of raw material medicated powder amount, filter, reclaim ethanol, being evaporated to 70 DEG C of relative densities is the thick paste of 1.25-1.28, for subsequent use;
(4) by step (1) and the mixing of step (3) gained thick paste, add the raw material medicated powder after step (2) process and sucrose fine, mix homogeneously, is processed into the pill of Semen Firmianae size, obtains final product.
The preparation method of the medicine pill of above-mentioned treatment gout, preferred scheme is, in step (3), the mass concentration of ethanol is the mass concentration of the preferred ethanol of 65%-85%(is 70%-80%, and the mass concentration of the ethanol be more preferably is 75%).
The preparation method of the medicine pill of above-mentioned treatment gout, preferred scheme is, in step (3), the volume ratio of second alcohol and water is the volume ratio of the preferred second alcohol and water of 1:2-4(is 1:2.5-3.5, and the volume ratio of the second alcohol and water be more preferably is 1:3).
The preparation method of described capsule is:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turns little fire and decocts 1.3 hours, fleshing gets decoction, and filter, being evaporated to 80 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(2) by Fructus Gardeniae, Fructus Liquidambaris, Juniperus rigida Sieb.et Zucc., Chinese photinia and Semen Strychni are placed in traditional Chinese medicine drying device, in 58-66 DEG C of dry 25-45 minute (being preferable over 62 DEG C of dryings 35 minutes), be ground into fine powder while hot, be placed in Chinese medicament extracting device, the mass concentration adding 4-7 times amount is the ethanol of 60%-80% (mass concentration preferably adding 5.5 times amount is the ethanol of 70%), heating and refluxing extraction twice, reflux, extract, 35-45 minute first time (preferred reflux, extract, for the first time 40 minutes), second time reflux, extract, 18-32 minute (preferably second time reflux, extract, 25 minutes), merge twice alcohol extract, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use,
(3) crude drug except step (1) and (2) is placed in Chinese medicine pan, add the cold water (preferably adding the cold water of 7.5 times of raw material doses) of 6-9 times of raw material dose, soak 1-3 hour (preferably soaking 2 hours), then intense fire is heated to boil, and turns slow fire boiling three times, each respectively decoction 25-35 minute (preferably each each decoction 30 minutes), merge three decocting liquids, filter, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) by step (1)-(3) gained thick paste mixing, in 78-82 DEG C of vacuum drying (being preferable over 80 DEG C of vacuum dryings), get dry extract powder, cools, and porphyrize adds adjuvant, mixing, stirs and granulate, dry, and granulate is crossed No. four sieves, incapsulated shell, to obtain final product.
The preparation method of the Chinese medicine capsules of above-mentioned treatment gout, preferred scheme is, adjuvant described in step (4) to be mass fraction be 10.5% corn starch and mass fraction be the sodium lauryl sulphate of 5.5%.
The preparation method of described decoction is:
(1) Folium daphnes odorae, Polyporus, Folium Callicarpae Formosanae, Caulis Trachelospermi and Chinese photinia is fully dry, be placed in Chinese medicine grinder and be ground into fine powder, cross 80-140 mesh sieve (preferred mistake 110 mesh sieve), obtain mixed powder, for subsequent use;
(2) Carnis Vulpes is cleaned, and cut fritter, add Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turn little fire and decoct 1.3 hours, fleshing gets decoction, and filter, filtrate is for subsequent use;
(3) crude drug except step (1) and (2) is placed in crock, add cold water and do not have powder 3-5cm, big fire heated and boiled 8-14 minute (preferred big fire heated and boiled 11 minutes), turn little fire and decoct twice slowly, each respectively decoction 34-56 minute (preferably each each decoction 45 minutes), merges twice decocting liquid, filtration, filtrate and step (2) gained filtrate merge, for subsequent use;
(4) join in step (3) gained filtrate by step (1) gained mixed powder, slow fire heating decocts 15-25 minute (preferred slow fire heating decoction 20 minutes), and filter, filtrate is concentrated into 1/3 of original volume, sterilizing, and cooling, to obtain final product.
The preparation method of described tablet is:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turn little fire and decoct 1.3 hours, fleshing gets decoction, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.18-1.20, and spraying dry gets dry extract powder, cools, porphyrize, for subsequent use;
(2) surplus stock medicine is fully dry, be ground into fine powder, mix with step (1) gained dried cream powder, cross 60-90 mesh sieve (preferred mistake 75 mesh sieve), add corn starch and magnesium stearate, mix homogeneously, is pressed into tablet according to the metering (preferably according to the metering of 0.3g/ sheet) of 0.25-0.35g/ sheet, obtains final product.
Scientific formula of the present invention, preparation method is simple, taking convenience, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,this prescription, while blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, strengthens relieving spasm to stop pain, the taste of the kidney invigorating nourishing the liver.Selected materials is all Chinese medicine material, without any side effects;
3,chinese medicinal formulae of the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has determined curative effect, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicinal formulae for the treatment of gout, is prepared from by following bulk drugs, is weight portion (every part of 10g): Fructus Gardeniae 12 parts; Radix clematidis floridae 8 parts; Folium daphnes odorae 9 parts; Carnis Vulpes 8 parts; Fructus Liquidambaris 7 parts; Radix Murrayae 11 parts; Polyporus 6 parts; Juniperus rigida Sieb.et Zucc. 11 parts; Folium Callicarpae Formosanae 9 parts; Caulis Trachelospermi 9 parts; Herba Damnacanthi 12 parts; Chinese photinia 7 parts; Semen Strychni 6 parts; Rhizoma Ligustici 7 parts; great Ye Rhizoma Curculiginis 10 parts.
The preparation method of the medicine pill for the treatment of gout is:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 20 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turns little fire and decocts 1 hour, fleshing gets decoction, and filter, being evaporated to 80 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(2) Fructus Gardeniae is pounded fragment, adds Sucus Zingberis and mixes thoroughly (Fructus Gardeniae: Rhizoma Zingiberis=10:3), vexed 10 minutes, put in parch container, and slow fire adds to propagandize hotly to Sucus Zingberis and exhausted completely, takes out, cools, porphyrize, for subsequent use; Semen Strychni and 12% yellow wine mix thoroughly, stew to moisten to wine to the greatest extent, put in parch, slow fire fry to golden yellow be degree, take out, cool, porphyrize, for subsequent use;
(3) by fully dry for the crude drug except step (1) and (2), be ground into fine powder, being placed in percolator by gained raw material medicated powder, take mass concentration as the second alcohol and water of 65% is solvent (volume ratio of second alcohol and water is for 1:2), carries out percolation according to percolation, percolate to be collected is 17 of raw material medicated powder amount, stop percolation, filter, reclaim ethanol, being evaporated to 70 DEG C of relative densities is the thick paste of 1.25-1.28, for subsequent use;
(4) by step (1) and the mixing of step (3) gained thick paste, add the raw material medicated powder after step (2) process and sucrose fine, mix homogeneously, is processed into the pill of Semen Firmianae size, obtains final product.
The instructions of taking of gained medicine pill of the present invention is: every day three times, each 8-10 ball, 15 days courses for the treatment of.
embodiment 2the Chinese medicinal formulae for the treatment of gout, is prepared from by following bulk drugs, is weight portion (every part of 10g): Fructus Gardeniae 16 parts; Radix clematidis floridae 17 parts; Folium daphnes odorae 19 parts; Carnis Vulpes 13 parts; Fructus Liquidambaris 12 parts; Radix Murrayae 15 parts; Polyporus 12 parts; Juniperus rigida Sieb.et Zucc. 16 parts; Folium Callicarpae Formosanae 13 parts; Caulis Trachelospermi 17 parts; Herba Damnacanthi 15 parts; Chinese photinia 15 parts; Semen Strychni 10 parts; Rhizoma Ligustici 11 parts; great Ye Rhizoma Curculiginis 16 parts.
The preparation method of the Chinese medicine capsules for the treatment of gout is:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turns little fire and decocts 1.3 hours, fleshing gets decoction, and filter, being evaporated to 80 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(2) Fructus Gardeniae, Fructus Liquidambaris, Juniperus rigida Sieb.et Zucc., Chinese photinia and Semen Strychni are placed in traditional Chinese medicine drying device, in 62 DEG C of dryings 35 minutes, are ground into fine powder while hot, be placed in Chinese medicament extracting device, the mass concentration adding 5.5 times amount is the ethanol of 70%, heating and refluxing extraction twice, for the first time reflux, extract, 40 minutes, second time reflux, extract, 25 minutes, merge twice alcohol extract, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(3) crude drug except step (1) and (2) is placed in Chinese medicine pan, adds the cold water of 7.5 times of raw material doses, soak 2 hours, then intense fire is heated to boil, turn slow fire boiling three times, each each decoction 30 minutes, merges three decocting liquids, filter, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) by step (1)-(3) gained thick paste mixing, in 80 DEG C of vacuum dryings, get dry extract powder, cool, porphyrize, add adjuvant (adjuvant to be mass fraction be 10.5% corn starch and mass fraction be the sodium lauryl sulphate of 5.5%), mixing, stir and granulate, drying, granulate, crosses No. four sieves, incapsulate shell, to obtain final product.
The instructions of taking of gained Chinese medicine capsules of the present invention is: every day three times, each 3-4 grain, 15 days courses for the treatment of.
Model case: grandson XX, man, 55 years old, patient's readme: after the evening before two weeks and colleague drink, during nearly midnight, occurred that suddenly right sufficient metatarsophalangeal joints swells and ache, and after pain wakes up, have difficulty in going to sleep, sensation affected part is scorching hot, red and swollen, companion's moving obstacle.Second day, after local hospital checks, gives anti-inflammatory drug treatment, has no improvement.Introduce by colleague, come my institute on April 13rd, 2010 and check treatment.Check: since patient idiopathy, the mental status is not good, poor sleeping quality, often feels weak.Patient temperature is slightly high, and affected part surrounding skin is red and swollen, has tenderness, companion's moving obstacle.Routine blood test: leukocyte 20.16 × 10
9/ L, hemoglobin 101g/L.Blood uric acid: 507 μm of ol/L.Be diagnosed as gout.
Take the Chinese medicine capsules of the present embodiment gained treatment gout, instructions of taking: every day three times, each 3-4 grain, 15 days courses for the treatment of.After taking a course for the treatment of, affected part redness disappears, and checks that blood uric acid is 445 μm of ol/L, and after continuing to take two courses for the treatment of, check that blood uric acid is normal, right ankle joint recovers normal.Patient's self-induction is fully recovered.Drug withdrawal was paid a return visit after three months, and nothing repeatedly.
embodiment 3the Chinese medicinal formulae for the treatment of gout, is prepared from by following bulk drugs, is weight portion (every part of 10g): Fructus Gardeniae 13 parts; Radix clematidis floridae 11 parts; Folium daphnes odorae 12 parts; Carnis Vulpes 9.5 parts; Fructus Liquidambaris 8.5 parts; Radix Murrayae 12 parts; Polyporus 8 parts; Juniperus rigida Sieb.et Zucc. 12.5 parts; Folium Callicarpae Formosanae 10 parts; Caulis Trachelospermi 11 parts; Herba Damnacanthi 13 parts; Chinese photinia 9.5 parts; Semen Strychni 7 parts; Rhizoma Ligustici 8 parts; great Ye Rhizoma Curculiginis 12 parts.
The preparation method of the Chinese medicine decoction for the treatment of gout is:
(1) Folium daphnes odorae, Polyporus, Folium Callicarpae Formosanae, Caulis Trachelospermi and Chinese photinia is fully dry, be placed in Chinese medicine grinder and be ground into fine powder, cross 110 mesh sieves, obtain mixed powder, for subsequent use;
(2) Carnis Vulpes is cleaned, and cut fritter, add Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turn little fire and decoct 1.3 hours, fleshing gets decoction, and filter, filtrate is for subsequent use;
(3) crude drug except step (1) and (2) is placed in crock, adds cold water and do not have powder 3-5cm, big fire heated and boiled 11 minutes, turn little fire and decoct twice slowly, each each decoction 45 minutes, merges twice decocting liquid, filter, filtrate and step (2) gained filtrate merge, for subsequent use;
(4) join in step (3) gained filtrate by step (1) gained mixed powder, slow fire heating decoction 20 minutes, filter, filtrate is concentrated into 1/3 of original volume, sterilizing, and cooling, to obtain final product.
The instructions of taking of gained Chinese medicine decoction of the present invention is: every day three times, each 100-120mL, 15 days courses for the treatment of.
embodiment 4the Chinese medicinal formulae for the treatment of gout, is prepared from by following bulk drugs, is weight portion (every part of 10g): Fructus Gardeniae 15 parts; Radix clematidis floridae 14 parts; Folium daphnes odorae 16 parts; Carnis Vulpes 11.5 parts; Fructus Liquidambaris 10.5 parts; Radix Murrayae 14 parts; Polyporus 10 parts; Juniperus rigida Sieb.et Zucc. 14.5 parts; Folium Callicarpae Formosanae 12 parts; Caulis Trachelospermi 15 parts; Herba Damnacanthi 14 parts; Chinese photinia 12.5 parts; Semen Strychni 9 parts; Rhizoma Ligustici 10 parts; great Ye Rhizoma Curculiginis 14 parts.
The preparation method of the Chinese medicinal tablet for the treatment of gout is:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turn little fire and decoct 1.3 hours, fleshing gets decoction, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.18-1.20, and spraying dry gets dry extract powder, cools, porphyrize, for subsequent use;
(2) surplus stock medicine fully be dry, pulverize into fine powder, mix with step (1) gained dried cream powder, cross 75 mesh sieves, add corn starch and magnesium stearate, mix homogeneously, be pressed into tablet according to the metering of 0.3g/ sheet, obtain final product.
The instructions of taking of gained Chinese medicinal tablet of the present invention is: every day three times, each 4-5 sheet, 15 days courses for the treatment of.
Model case: relative XX, female, 60 years old, patient's readme: biped suffers from gout and has a surplus for 2 years.Time serious, the swelling of biped arthralgia, cannot normally walk, and biped heel has tenderness, and after certain hospitalize, alleviate ailing by taking Western medicine, because taking Western medicine for a long time, patient engenders that waist is aching and limp unable, sleeps poor, degradation side effect under appetite always.Patient was through making some inquiries about afterwards, comes my institute check treatment on November 6th, 2013.Check: patient's biped Metatarsophalangeal joint red swelling of the skin, pain, biped, with obvious tenderness, has slight swelling.Blood routine examination is normal, and blood uric acid is 446 μm of ol/L.Be diagnosed as gout.
Take the Chinese medicinal tablet of the present embodiment gained treatment gout, instructions of taking: every day three times, each 4-5 sheet, 15 days courses for the treatment of.After taking a course for the treatment of, the symptoms such as patient articular's pain and swelling obviously alleviate, and blood uric acid is 413 μm of ol/L.Continue two courses for the treatment of of medication, check that blood uric acid is normal, biped joint recovers normal.Can be movable voluntarily, patient's self-induction is fully recovered.Drug withdrawal was paid a return visit after three months, and nothing repeatedly.
embodiment 5the Chinese medicinal formulae for the treatment of gout, is prepared from by following bulk drugs, is weight portion (every part of 10g): Fructus Gardeniae 14 parts; Radix clematidis floridae 12.5 parts; Folium daphnes odorae 14 parts; Carnis Vulpes 10.5 parts; Fructus Liquidambaris 9.5 parts; Radix Murrayae 13 parts; Polyporus 9 parts; Juniperus rigida Sieb.et Zucc. 13.5 parts; Folium Callicarpae Formosanae 11 parts; Caulis Trachelospermi 13 parts; Herba Damnacanthi 13.5 parts; Chinese photinia 11 parts; Semen Strychni 8 parts; Rhizoma Ligustici 9 parts; great Ye Rhizoma Curculiginis 13 parts.
The preparation method of the medicine pill for the treatment of gout is:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turns little fire and decocts 1.3 hours, fleshing gets decoction, and filter, being evaporated to 80 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(2) Fructus Gardeniae is pounded fragment, adds Sucus Zingberis and mixes thoroughly (Fructus Gardeniae: Rhizoma Zingiberis=10:3), vexed 18 minutes, put in parch container, and slow fire adds to propagandize hotly to Sucus Zingberis and exhausted completely, takes out, cools, porphyrize, for subsequent use; Semen Strychni and 12% yellow wine mix thoroughly, stew to moisten to wine to the greatest extent, put in parch, slow fire fry to golden yellow be degree, take out, cool, porphyrize, for subsequent use;
(3) by fully dry for the crude drug except step (1) and (2), be ground into fine powder, being placed in percolator by gained raw material medicated powder, take mass concentration as the second alcohol and water of 75% is solvent (volume ratio of second alcohol and water is for 1:3), carries out percolation according to percolation, percolate to be collected is 19 times of raw material medicated powder amount, stop percolation, filter, reclaim ethanol, being evaporated to 70 DEG C of relative densities is the thick paste of 1.25-1.28, for subsequent use;
(4) by step (1) and the mixing of step (3) gained thick paste, add the raw material medicated powder after step (2) process and sucrose fine, mix homogeneously, is processed into the pill of Semen Firmianae size, obtains final product.
The instructions of taking of gained medicine pill of the present invention is: every day three times, each 8-10 ball, 15 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Gardeniae: base is former: be the fruit of Maguireothamnus speciosus Fructus Gardeniae.Bitter in the mouth, cold.GUIXIN, liver, lung, stomach warp.Main chemical compositions is for containing flavonoid gardenin, pectin, tannin, crocin, crocetin, PEARLITOL 25C, nonacosane, cupreol.The another glycoside containing the smelly formaldehyde structure of multiple tool ring: gardenoside, geniposide pool element-1-glycoside, lattice Tegosept P-1-β-D-gentiobioside and shanzhiside in a small amount.There is heat clearing away, pathogenic fire purging, effect of removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.
Radix clematidis floridae: base is former: Ranunculaceae Actions of Clematis Species Radix clematidis floridae, with root and all herbal medicine.Chemical analysis: root is containing hederagenin.Nature and flavor: bitter in the mouth; Micro-pungent; Warm in nature; Mild toxicity.Gui Jing: return liver; Spleen; Kidney channel.Function cures mainly: diuresis; Dredging collateral; Regulating the flow of QI to relieve constipation; Removing toxic substances.Cure mainly rheumatic arthritis; Dysuria; Amenorrhea; Constipation abdominal distention; Acute toothache; Eye plays punctate keratitis; Worm venom; Jaundice.
Folium daphnes odorae: base is former: be the branch and leaf of Isolated From Thymelaeaceae Species winter daphne.Nature and flavor: acrid in the mouth; Property is put down.Gui Jing: lung; Spleen channel.Function cures mainly: removing toxic substances; Reducing swelling and alleviating pain.Main skin infection; Acute mastitis; Gout.
Carnis Vulpes: base is former: be the meat of Canis animals Vulpes.Nature and flavor: sweet, temperature.Gui Jing: the heart; Spleen; Stomach; Kidney channel.Function cures mainly: tranquillizing and allaying excitement during tonify deficiency is warm; Dispel the wind; Removing toxic substances.Main asthenia is won thin; Abdominal pain due to accumulation of cold; Hysteria; Infantile convulsion; Gout; Edema; Scabies; Children's's ovum swells.
Fructus Liquidambaris: base is former: be the fruit of Hamamelidaceae Plants sweetgum.Pharmacological action: experiment proves, sweetgum spirit solvent (60%) external, can prevent the hook larva of a tapeworm or the cercaria of a schistosome from invading mouse skin.Its protection effect is directly proportional to solvent strength.Nature and flavor: bitter are flat.Gui Jing: " detailed outline is picked up any lost article from the road ": " current 12 warps." function cures mainly: dispelling wind and removing obstruction in the collateral, diuretic dehumidifies.Control limbs arthralgia pain, contracture of the limbs, stomachache, edema, distension, amenorrhea, breast is few, carbuncle, anal fistula, scabies, eczema.
Radix Murrayae: base is former: the root of rutaceae Folium Et Cacumen Murrayae, autumn adopts, and removes earth, and section, dries.Nature and flavor: " mountain of papers Chinese herbal medicine ": " acrid in the mouth is bitter, warm in nature." return through " Guangxi Chinese medicinal herbal ": " enter the heart, liver, lung three warp." function cures mainly: dispelling the wind and dampness pathogens arthralgia pain, lumbago, traumatic injury, painful and swollen testis, eczema, scabies.
Polyporus: base is former: this product is the dry sclerotia of On Polyporaceae Polyporus.Chemical analysis: containing ergosterol, biotin, saccharide, protein.Nature and flavor: sweet, light are flat.Gui Jing: return kidney, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen.Cure mainly: for dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia.
Juniperus rigida Sieb.et Zucc.: base is former: medical material Ji Yuan: be branch and leaf and the cone of Cupressaceae plant Juniperus rigida Sieb.et Zucc..Chemical analysis: cone, containing volatile oil, mainly contains australene, myrcene, limonene, to P-cymene, beta-elemene, Flos Caryophylli alkene, Humuleno, γ-cadinene, terpinene-4-alcohol, Borneolum Syntheticum, citronellol and methoxybenzene etc.Leaf contains amentoflavone, podocarpusflavone A, hinokiflavone.Branch, leaf are containing volatile oil, and its composition is similar to fruit volatile oil.Heartwood is containing various terpenoid and organic acid such as α-and β-cedrenes.Pharmacological action: Juniperus rigida Sieb.et Zucc. seed ligroin extraction has inhibitory action to staphylococcus aureus in vitro, is diluted to 1:1600 and still can prevents Bacterial Development.Nature and flavor: sweet; Bitter; Property is put down.Function cures mainly: dispel the wind; Analgesia; Dehumidifying; Diuresis.Main rheumatic arthritis; Gout; Nephritis; Edema; Urinary tract infection.
Folium Callicarpae Formosanae: be Herba Verbenae Callicarpa plant Folium Callicarpae Macrophyllae, be used as medicine with root and leaf.Nature and flavor: pungent, bitter are flat.Gui Jing: return liver, spleen, stomach warp.Effect: dissipating blood stasis stops blooding, reducing swelling and alleviating pain.Composition: containing flavonoid, condensed tannin.Still containing resinene, saccharide, hydroxy compounds and magnesium, calcium, iron salt.Cure mainly: leaf: for spitting blood, spitting of blood, epistaxis, has blood in stool; External curing traumatic hemorrhage.Root: treating swelling and pain by traumatic injury, rheumatic ostalgia.Pharmacological action: 1. anastalsis: Folium Callicarpae Formosanae injection can make platelet increase to people, bleeding time, clot retration time, prothrombin time shorten.2. antibacterial action: Folium Callicarpae Formosanae has inhibitory action to escherichia coli, bacterium flexneri, staphylococcus aureus, streptococcus etc.
Caulis Trachelospermi: base is former: be stem, the leaf of apocynaceae plant trachelospermum jasminoide.Chemical analysis: stem is containing arctigenin, tracheloside, matairesinoside, nortracheloside, dambonitol, cupreol glycoside, cymarose etc.Pharmacological action: arctigenin can cause vasodilation, blood pressure drops, make cold-blooded and homoiothermic animal generation convulsions, heavy dose causes respiratory failure, and makes mouse skin rubescent, and diarrhoea, then suppresses it to isolated rabbit intestinal and uterus.Nature and flavor: bitter, cool.Gui Jing: enter liver, kidney channel.Function cures mainly: dispel the wind, dredging collateral, hemostasis, repercussive.Dispelling the wind and dampness pathogens arthralgia pain, the contracture of muscle arteries and veins, carbuncle, sore throat, spits blood, traumatic injury, disease that postpartum lochia can't go.
Herba Damnacanthi: base is former: be herb or the root of Maguireothamnus speciosus Herba Damnacanthi.Chemical analysis: the root of large shape Herba Damnacanthi is containing multiple anthraquinone component damnacanthal, damnacanthol, damnidin, juzunal, demethyl damnacanthal, Norjuzunal, benzylxanthopurpurin, alizarin-1-methyl ether, 5-hydroxyl alizarin-1-methyl ether.Nature and flavor: bitter sweet are flat.Function cures mainly: expelling wind and removing dampness, promoting blood circulation and detumescence.Control gout, rheumatic arthralgia.Cough due to fluid-retention, lung abscess, edema, mass in the abdomen, jaundice, women's amenorrhea, infantile malnutrition, urticaria, traumatic injury.
Photiniaserrulata: base is former: be leaf or the band leaf twig of rosaceous plant Chinese photinia.Chemical analysis: leaf, branch cyanogenetic glycoside, do not contain in root.Leaf is containing free hydrocyanic acid, and its changes of contents is comparatively large, is about 0.015%-0.120%; Another containing wild cherry skin glycoside, obtain glucose, benzaldehyde and hydrocyanic acid after hydrolysis.Pharmacological action: 10% leaf preserved material can kill schistosoma japonicum cercariae in vitro, also can Killing Oncomelania Hupensis.70% leaf alcohol leaching liquid can suppress isolated frog heart, shrinks in vitro rabbit ear blood vessel, suppresses intestine in vitro, reduces anaesthetized dog blood pressure.There are heart tonifying, diuresis, bacteriostasis.3.7% decoct to isolated frog heart, 100% decoct through saccus lymphaticus administration at the body frog heart, or 75% decoct 10ml intravenous injection all has excitation at body Cor Leporis.Nature and flavor: acrid in the mouth; Bitter; Property is put down; Mild toxicity.Gui Jing: liver; Kidney channel.Function cures mainly: wind-damp dispelling; Antipruritic; Bone and muscle strengthening; Liver and kidney tonifying.Main air pain of dampness syndrome; Wind syndrome of head is had a headache; Rubella; Flaccidity of feet and knees; Lumbago due to renal deficiency; Sexual impotence; Seminal emission.
Semen Strychni: base is former: be the mature seed of loganiaceae plant Semen Strychni.Chemical analysis: containing brucine, strychnine, α-and β-Ke Lubo, vomicine, novacine, icajine, loganin etc.Nature and flavor: bitter, cold, poisonous.Gui Jing: liver; Spleen channel.Function cures mainly: dredging collateral; Strong muscle; Eliminating stagnation; Pain relieving; Detumescence; Removing toxic substances.Main air pain of dampness syndrome; Numbness of the skin; Quadriplegia; Traumatic injury; Fracture swells and ache; Skin sore.Sore throat; Toothache; Leprosy; Stubborn dermatitis; Malignant tumor.
Rhizoma Ligustici: base is former: this product is dry rhizome and the root of samphire Rhizoma Ligustici or Rhizoma Ligustici.Character: Rhizoma Ligustici rhizome is that irregular nodular pattern is cylindrical, and slightly distortion, has branch.Surface sepia or burgundy, coarse, have vertical wrinkle, upside remains the circular stem foot of several depression, and there are root trace and the undesirable root of most spot-like projections in downside.Body is light, and matter is comparatively hard, frangibility, section yellow or yellow-white, threadiness.Gas giving off a strong fragrance, acrid in the mouth, hardship, micro-fiber crops.Rhizoma Ligustici is less in river, and rhizome is irregular lumps or column, has the root of most elongate curved.Nature and flavor: pungent, temperature.Gui Jing: return urinary bladder channel.Effect: dispel the wind, cold expelling, dehumidifying, pain relieving.Cure mainly: for anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain.
Great Ye Rhizoma Curculiginis: base is former: Hypoxidaceae Curculigo great Ye Rhizoma Curculiginis, is used as medicine with root and root stock.Another name the earth palm fibre, monkey back of the body towel, monkey packet header, bamboo Ganoderma.Nature and flavor: bitter, puckery are flat.Function: moistening the lung and resolving phlegm, relieving cough and asthma, calm spleen invigorating, tonifying the kidney to consolidate the essence.Be applicable to dyspnea and cough due to deficiency of the kidney, soreness of waist and knee joint, leucorrhea, seminal emission.
test example 1the clinical practice of the Chinese medicinal formulae (embodiment 5) of gained treatment gout of the present invention:
1, data and method
1.1 physical data
Choose patient with gout that in October ,-2013 in May, 2011, my institute accepted for medical treatment totally 266 examples, the age 36-68 year, 44.5 ± 3.5 years old mean age, wherein male patient's totally 146 examples, female patient is totally 120 examples.The course of disease was-7 years half a year.All patients are at the age, and the aspect such as the state of an illness, the course of disease is through statistical procedures, and no significant difference (P > 0.05), has comparability.
1.2 diagnostic criteria
(1) have constitutional metabolic arthritis disease, Level of Serum Uric Acid exceedes normal value.
(2) arthritis symptoms, the redness and swelling of joints based on Metatarsophalangeal joint, pain, limitation of activity.
(3) gout calculus or renal damage is had.
Meet above-mentioned two and above patient all diagnosable for gout.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random, and experimental group takes products obtained therefrom of the present invention, instructions of taking: every day three times, each 8-10 ball, 15 days courses for the treatment of.Matched group takes other medicines (as conventional medication such as gout relaxing tablet, colchicines tablets, TONGFENGDING).Observe three courses for the treatment of of treatment altogether.
1.4 curative effect determinate standard
Clinical cure: symptom and sign disappear completely, lab testing is normal, and blood uric acid drops to range of normal value.
Effective: cardinal symptom and sign are obviously improved, and laboratory checking index is normal, blood uric acid decline and close to normal value.
Take a turn for the better: clinical symptoms and sign alleviate to some extent, and laboratory checking index makes moderate progress, and blood uric acid declines to some extent but do not arrive normal value.
Invalid: compared with before treatment, symptom, sign and lab testing are without improvement.
Total effective rate=(clinical cure number of cases+effective number of cases+improvement number of cases)/total case × 100%.
1.5 therapeutic outcome
Therapeutic outcome after two groups of patient treatments, as shown in table 1:
Table 1: the therapeutic outcome of experimental group and matched group compares
Therapeutic effect: experimental group clinical cure 106 example (63.9%), effective 32 examples (19.3%), 25 examples that take a turn for the better (15%); Invalid 3 examples (1.8%), total effective rate 98.2%.Successful is better than matched group.
The present invention select Fructus Gardeniae, Radix clematidis floridae, Folium daphnes odorae, Carnis Vulpes, Fructus Liquidambaris, Radix Murrayae, Polyporus, Juniperus rigida Sieb.et Zucc., Folium Callicarpae Formosanae and Caulis Trachelospermi etc. totally 15 taste primary raw material medicines be prepared from.Fang Zhong, Fructus Gardeniae has heat clearing away, pathogenic fire purging, effect of removing heat from blood; Radix clematidis floridae diuresis; Dredging collateral; Removing toxic substances; During Carnis Vulpes tonify deficiency is warm, tranquillizing and allaying excitement, dispels the wind; Fructus Liquidambaris dispelling wind and removing obstruction in the collateral, diuretic dehumidifies; Polyporus promoting diuresis to eliminate damp pathogen; Juniperus rigida Sieb.et Zucc. is dispeled the wind, analgesia, dehumidifying, diuresis; Folium Callicarpae Formosanae dissipating blood stasis stops blooding, reducing swelling and alleviating pain; Caulis Trachelospermi is dispeled the wind, dredging collateral, hemostasis; Herba Damnacanthi expelling wind and removing dampness, promoting blood circulation and detumescence; Rhizoma Ligustici is dispeled the wind, cold expelling, dehumidifying, pain relieving; All medicines share, and play effect of clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, the kidney invigorating nourishing the liver, heat-clearing and toxic substances removing altogether.After treating three courses for the treatment of, treatment group effective percentage can reach 98.2%, and matched group is only 78%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicinal formulae of gout, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Gardeniae 12-16; Radix clematidis floridae 8-17; Folium daphnes odorae 9-19; Carnis Vulpes 8-13; Fructus Liquidambaris 7-12; Radix Murrayae 11-15; Polyporus 6-12; Juniperus rigida Sieb.et Zucc. 11-16; Folium Callicarpae Formosanae 9-13; Caulis Trachelospermi 9-17; Herba Damnacanthi 12-15; Chinese photinia 7-15; Semen Strychni 6-10; Rhizoma Ligustici 7-11; great Ye Rhizoma Curculiginis 10-16.
2. the Chinese medicinal formulae for the treatment of gout as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Gardeniae 13-15; Radix clematidis floridae 11-14; Folium daphnes odorae 12-16; Carnis Vulpes 9.5-11.5; Fructus Liquidambaris 8.5-10.5; Radix Murrayae 12-14; Polyporus 8-10; Juniperus rigida Sieb.et Zucc. 12.5-14.5; Folium Callicarpae Formosanae 10-12; Caulis Trachelospermi 11-15; Herba Damnacanthi 13-14; Chinese photinia 9.5-12.5; Semen Strychni 7-9; Rhizoma Ligustici 8-10; great Ye Rhizoma Curculiginis 12-14.
3. the Chinese medicinal formulae for the treatment of gout as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Gardeniae 14; Radix clematidis floridae 12.5; Folium daphnes odorae 14; Carnis Vulpes 10.5; Fructus Liquidambaris 9.5; Radix Murrayae 13; Polyporus 9; Juniperus rigida Sieb.et Zucc. 13.5; Folium Callicarpae Formosanae 11; Caulis Trachelospermi 13; Herba Damnacanthi 13.5; Chinese photinia 11; Semen Strychni 8; Rhizoma Ligustici 9; great Ye Rhizoma Curculiginis 13.
4. the Chinese medicinal formulae of the treatment gout as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Carnis Vulpes is cleaned, cut fritter, add Chinese liquor and mix thoroughly, pickle 20-30 minute (preferably pickling 25 minutes), be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turns little fire and decocts 1-1.5 hour (preferably turning little fire to decoct 1.3 hours), fleshing gets decoction, filter, being evaporated to 80 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(2) Fructus Gardeniae is pounded fragment, adds Sucus Zingberis and mixes thoroughly (Fructus Gardeniae: Rhizoma Zingiberis=10:3), and vexed 10-25 minute (preferably vexed 18 minutes), put in parch container, and slow fire adds to propagandize hotly to Sucus Zingberis and exhausted completely, takes out, cools, porphyrize, for subsequent use; Semen Strychni and 12% yellow wine mix thoroughly, stew to moisten to wine to the greatest extent, put in parch, slow fire fry to golden yellow be degree, take out, cool, porphyrize, for subsequent use;
(3) by fully dry for the crude drug except step (1) and (2), be ground into fine powder, gained raw material medicated powder is placed in percolator, with second alcohol and water for solvent, carries out percolation according to percolation, percolate to be collected is 17-21 times (percolate preferably to be collected is 19 times of raw material medicated powder amount) of raw material medicated powder amount, stop percolation, filter, reclaim ethanol, being evaporated to 70 DEG C of relative densities is the thick paste of 1.25-1.28, for subsequent use;
(4) by step (1) and the mixing of step (3) gained thick paste, add the raw material medicated powder after step (2) process and sucrose fine, mix homogeneously, is processed into the pill of Semen Firmianae size, obtains final product.
5. the preparation method of the medicine pill for the treatment of gout according to claim 4, it is characterized in that, in step (3), the mass concentration of ethanol is the mass concentration of the preferred ethanol of 65%-85%(is 70%-80%, and the mass concentration of the ethanol be more preferably is 75%).
6. the preparation method of the medicine pill for the treatment of gout according to claim 4, it is characterized in that, in step (3), the volume ratio of second alcohol and water is the volume ratio of the preferred second alcohol and water of 1:2-4(is 1:2.5-3.5, and the volume ratio of the second alcohol and water be more preferably is 1:3).
7. the Chinese medicinal formulae of the treatment gout as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turns little fire and decocts 1.3 hours, fleshing gets decoction, and filter, being evaporated to 80 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use;
(2) by Fructus Gardeniae, Fructus Liquidambaris, Juniperus rigida Sieb.et Zucc., Chinese photinia and Semen Strychni are placed in traditional Chinese medicine drying device, in 58-66 DEG C of dry 25-45 minute (being preferable over 62 DEG C of dryings 35 minutes), be ground into fine powder while hot, be placed in Chinese medicament extracting device, the mass concentration adding 4-7 times amount is the ethanol of 60%-80% (mass concentration preferably adding 5.5 times amount is the ethanol of 70%), heating and refluxing extraction twice, reflux, extract, 35-45 minute first time (preferred reflux, extract, for the first time 40 minutes), second time reflux, extract, 18-32 minute (preferably second time reflux, extract, 25 minutes), merge twice alcohol extract, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.18-1.20, for subsequent use,
(3) crude drug except step (1) and (2) is placed in Chinese medicine pan, add the cold water (preferably adding the cold water of 7.5 times of raw material doses) of 6-9 times of raw material dose, soak 1-3 hour (preferably soaking 2 hours), then intense fire is heated to boil, and turns slow fire boiling three times, each respectively decoction 25-35 minute (preferably each each decoction 30 minutes), merge three decocting liquids, filter, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) by step (1)-(3) gained thick paste mixing, in 78-82 DEG C of vacuum drying (being preferable over 80 DEG C of vacuum dryings), get dry extract powder, cools, and porphyrize adds adjuvant, mixing, stirs and granulate, dry, and granulate is crossed No. four sieves, incapsulated shell, to obtain final product.
8. the preparation method of the Chinese medicine capsules for the treatment of gout according to claim 7, is characterized in that, adjuvant described in step (4) to be mass fraction be 10.5% corn starch and mass fraction be the sodium lauryl sulphate of 5.5%.
9. the Chinese medicinal formulae of the treatment gout as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Folium daphnes odorae, Polyporus, Folium Callicarpae Formosanae, Caulis Trachelospermi and Chinese photinia is fully dry, be placed in Chinese medicine grinder and be ground into fine powder, cross 80-140 mesh sieve (preferred mistake 110 mesh sieve), obtain mixed powder, for subsequent use;
(2) Carnis Vulpes is cleaned, and cut fritter, add Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turn little fire and decoct 1.3 hours, fleshing gets decoction, and filter, filtrate is for subsequent use;
(3) crude drug except step (1) and (2) is placed in crock, add cold water and do not have powder 3-5cm, big fire heated and boiled 8-14 minute (preferred big fire heated and boiled 11 minutes), turn little fire and decoct twice slowly, each respectively decoction 34-56 minute (preferably each each decoction 45 minutes), merges twice decocting liquid, filtration, filtrate and step (2) gained filtrate merge, for subsequent use;
(4) join in step (3) gained filtrate by step (1) gained mixed powder, slow fire heating decocts 15-25 minute (preferred slow fire heating decoction 20 minutes), and filter, filtrate is concentrated into 1/3 of original volume, sterilizing, and cooling, to obtain final product.
10. the Chinese medicinal formulae of the treatment gout as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Carnis Vulpes is cleaned, and cuts fritter, adds Chinese liquor and mix thoroughly, pickle 25 minutes, be placed in marmite, add clear water and do not have cube meat, big fire is heated to boil, and turn little fire and decoct 1.3 hours, fleshing gets decoction, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.18-1.20, and spraying dry gets dry extract powder, cools, porphyrize, for subsequent use;
(2) surplus stock medicine is fully dry, be ground into fine powder, mix with step (1) gained dried cream powder, cross 60-90 mesh sieve (preferred mistake 75 mesh sieve), add corn starch and magnesium stearate, mix homogeneously, is pressed into tablet according to the metering (preferably according to the metering of 0.3g/ sheet) of 0.25-0.35g/ sheet, obtains final product.
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| CN1683001A (en) * | 2005-03-14 | 2005-10-19 | 庹元斌 | Chinese medicine for treating gout |
| CN102988843A (en) * | 2012-12-03 | 2013-03-27 | 刘富臻 | Traditional Chinese medicine Tongfengling used for treating chronic gouty arthritis |
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