CN104436018A - Medicine for treating tumors and preparation method thereof - Google Patents

Medicine for treating tumors and preparation method thereof Download PDF

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CN104436018A
CN104436018A CN201410626601.3A CN201410626601A CN104436018A CN 104436018 A CN104436018 A CN 104436018A CN 201410626601 A CN201410626601 A CN 201410626601A CN 104436018 A CN104436018 A CN 104436018A
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radix
herba
medicine
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water
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CN104436018B (en
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刘尚义
唐东昕
杨柱
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Guizhou University of Traditional Chinese Medicine
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Guiyang College of Traditional Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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    • A61K36/8969—Polygonatum (Solomon's seal)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention discloses a medicine for treating tumors and a preparation method thereof. The medicine is prepared from a turtle shell, curcuma zedoary, dried toad skin, rabdosia rubescens, lily, coix seeds, rhizoma polygonati, ligusticum wallichii, subprostrate sophora, salviae miltiorrhizae, ground beeltle, radix curcumae, uniflower swisscentaury root, clematis chinensis, solanum lyratum, nightshade, oldenlandia diffusa, sculellaria barbata, notoginseng powder and auxiliary materials. The medicine disclosed by the invention has the effects of resolving hard lumps, and detoxicating and activating blood (nourishing yin, promoting blood circulation, removing stasis, and disintegrating masses), and is suitable for subcutaneous nodule, phlegm-damp oozing in the body, abdominal mass in the body, and various cancers, malignant and benign tumors in western medicine diagnosis; and the prepared medicine is significant in curative effect, and small in toxic and side effects.

Description

Medicine for the treatment of tumor and preparation method thereof
Technical field
The present invention relates to a kind of medicine (having another name called toad spirit cream) for the treatment of tumor and preparation method thereof, belong to the field of medicine technology.
Background technology
Tumor (Tumor) be body under various carcinogenic factor effect, some cells of local organization lose the normal regulation to its growth on gene level, cause its clonal abnormality hypertrophy and the abnormality that formed.Tumor is generally divided into optimum and pernicious two large classes by educational circles.Malignant tumor is cancer.Tumor is one of important arch-criminal that global disease is lethal.According to statistics, just there are 173 people in new every 100,000 people of tumor patient in the whole world, in every 100,000 people of China, have 110 people.Producing blastomogenic reason has a lot, as air, and water source, the pollution of food all allows tumor have opportunity, mouldy Semen arachidis hypogaeae, Semen sojae atricolor, rice, flour, plant wet goods in life, and the flavacin of generation has strong carcinogenecity; The food smoked or pickle, as bacon, bacon, cured fish, sauerkraut, salts down vegetables, containing a kind of chemical substance that may cause gastric cancer and esophageal carcinoma in these foods; The materials such as the tar in medicated cigarette are the carcinogenic factors causing pulmonary carcinoma and cancer of pancreas; The ethanol that concentration is high can stimulate oral cavity, esophageal wall and coat of the stomach epithelial cell and cause canceration; The black smoke of emerging in smokestack, is contained a small amount of carcinogen by the air that it pollutes; Food, hormone medicine, heavy dose of vitamin e etc. that poisonous plastic (polrvinyl chloride) was packed can be carcinogenic, and these carcinogenic factors easily ignored, make people hard to guard against.Western medicine is thought, the generation of cancer is due to genovariation, as long as it is all right to kill sick cell cancer, so doctor trained in Western medicine often adopts the method for chemicotherapy and operation to carry out Therapeutic cancer, but chemicotherapy is very large to the harm of human body, and while killing cancerous cell, a large amount of normal cells is also killed or is disabled, people is sapped one's vitality, more easily recurs.Chinese medicine is thought, the generation of cancer is because the mismanagement of entirety causes, and the management recovering overall just can make cancerous cell turn over a new leaf, but Chinese traditional treatment cancer is slowly effective, therefore, although patient adopts the method for the combination of Chinese and Western medicine to carry out Therapeutic cancer mostly, but still be main flow with western medicine therapy.Therefore a kind of successful is provided, effectively can kills cancerous cell, and the Chinese medicine not allowing people sap one's vitality has great importance.
Summary of the invention
The object of the present invention is to provide a kind of medicine (having another name called toad spirit cream) for the treatment of tumor and preparation method thereof.Effect that described medicine has hard masses softening and resolving, removing toxic substances is invigorated blood circulation (nourishing yin and activating blood, eliminating stagnation Disorder); Be applicable to subcutaneous nodule, phlegm-damp oozing in the body, Ti Nei mass in the abdomen, all kinds of cancers, pernicious, the benign tumors of western medicine diagnosis.
For solving above technical problem, the present invention realizes by the following technical solutions:
A kind of medicine for the treatment of tumor, it is characterized in that: component calculates by weight, is prepared from by Carapax Trionycis 30-80 part, Rhizoma Curcumae 80-120 part, dry maxima skin 20-40 part, Rabdosia rubescens 30-80 part, Bulbus Lilii 30-80 part, Semen Coicis 80-120 part, Rhizoma Polygonati 80-120 part, Rhizoma Chuanxiong 30-80 part, Radix Sophorae Tonkinensis 30-80 part, Radix Salviae Miltiorrhizae 30-80 part, Eupolyphaga Seu Steleophaga 20-60 part, Radix Curcumae 20-60 part, Radix Rhapontici 10-50 part, Radix Clematidis 10-50 part, Herba Solani Lyrati 10-30 part, Herba Solani Nigri 10-30 part, Herba Hedyotidis Diffusae 20-60 part, Herba Scutellariae Barbatae 20-60 part, Radix Notoginseng powder 30-80 part and adjuvant.
Specifically, the medicine of aforementioned therapies tumor, is prepared from by Carapax Trionycis 50 parts, Rhizoma Curcumae 100 parts, dry maxima skin 30 parts, Rabdosia rubescens 50 parts, Bulbus Lilii 50 parts, Semen Coicis 100 parts, Rhizoma Polygonati 100 parts, Rhizoma Chuanxiong 50 parts, Radix Sophorae Tonkinensis 50 parts, Radix Salviae Miltiorrhizae 50 parts, Eupolyphaga Seu Steleophaga 40 parts, Radix Curcumae 40 parts, Radix Rhapontici 25 parts, Radix Clematidis 30 parts, Herba Solani Lyrati 20 parts, Herba Solani Nigri 20 parts, Herba Hedyotidis Diffusae 40 parts, Herba Scutellariae Barbatae 40 parts, Radix Notoginseng powder 50 parts and adjuvant.
The preparation method of the medicine of aforementioned therapies tumor is: according to all medicines in the prescription ratio side of taking, combine, and preparation method is conveniently processed, make corresponding pharmaceutical preparation with acceptable pharmaceutic adjuvant in medicine.
Specifically, the preparation method of the medicine of aforementioned therapies tumor is: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 0.5-2h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Extract soak by water 2-3 time that the medicinal residues after volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati add 6-8 times amount jointly, each 0.5-2h, three times decocting liquid filters, merge, be condensed into extractum, then add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder, mixing, mix with conventional pharmaceutical adjuvants, more conventionally make different pharmaceutical preparation.
More particularly, the preparation method of the medicine of aforementioned therapies tumor is: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, the extractum of the 1.10-1.15 that relative density is when being condensed into 60-65 DEG C, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, mixing, mix with conventional pharmaceutical adjuvants, more conventionally make different pharmaceutical preparation.
Described pharmaceutical preparation is soft extract, capsule, ointment, tablet, granule, pill, powder, sublimed preparation, plaster, cream or patch.Be specially: soft extract, capsule, granule or tablet.
Described soft extract is prepared like this: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add the Mel of extractum amount 20%, agitating heating, when being concentrated into 60-65 DEG C, relative density is the extractum of 1.2-1.25, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, mixing, to obtain final product.
Described capsule is prepared like this: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, and the dextrin of the amount of making 10% and 0.5% magnesium stearate mix homogeneously, with the alcohol granulation of 65%, dry, granulate, load capsule, to obtain final product.
Described granule is prepared like this: get dry maxima skin and be ground into fine powder, for subsequent use, separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use, extract the medicinal residues after volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add above-mentioned Bufo siccus corium farinosum again, volatile oil and Radix Notoginseng powder, and the dextrin of the amount of making 15% and 15% sucrose mixing mixing, be wetting agent granule with 85% ethanol, 60 DEG C of dryings, after 12 mesh sieve 1 time, and separate fine powder with 60 mesh sieves, obtain.
Described tablet is prepared like this: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, and the starch of the amount of making 20% and 1% magnesium stearate mixing, tabletting, coating, to obtain final product.
Pharmaceutical composition of the present invention is when making medicament, and the medicament of unit dose can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable adjuvant.Pharmaceutically acceptable adjuvant can be the 0.1-99.9% of total formulation weight amount by weight.
Medicine of the present invention is prepared from by Carapax Trionycis, Rhizoma Curcumae, dry maxima skin, Rabdosia rubescens, Bulbus Lilii, Semen Coicis, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Sophorae Tonkinensis, Radix Salviae Miltiorrhizae, Eupolyphaga Seu Steleophaga, Radix Curcumae, Radix Rhapontici, Radix Clematidis, Herba Solani Lyrati, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Notoginseng powder and adjuvant.Carapax Trionycis is the carapace that Trionychidae class is dried, salty, cold, nourishing kidney YANG hyperactivity suppressing, hard masses softening and resolving, for hard under hectic fever due to YIN-deficiency consumptive fever, malaria with splenomegaly, the side of body, lumbago, and the diseases such as amenorrhea lump in the abdomen.Rhizoma Curcumae is Curcuma perennial root draft, it is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary Curcuma Kwangsiensis S. G.Lee et C. F. Liang or RADIX CURCUMAE Curcuma wenyujin Y.H. Chen et C. Ling, pungent, bitter, temperature, returns liver, spleen channel, for removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.The skin of the dryings such as dry maxima skin is Bufonidae animal Bufo siccus or Bufo melanostictus, acrid in the mouth, warm in nature, poisonous, can removing toxic substances, pain relieving, have one's ideas straightened out, refreshment, for hepatitis, hepatocarcinoma, hepatic ascites, skin carcinoma, gastric cancer, pulmonary carcinoma, the esophageal carcinoma, intestinal cancer etc., to nephropathy cyclomastopathy, edema, edema, hysteromyoma.Rabdosia rubescens is the herb of Labiatae drying, bitter, sweet, be slightly cold, heat clearing away poison, promoting blood circulation and stopping pain, antibacterial, antitumor, for laryngopharynx swelling and pain, tonsillitis, headache due to common cold, tracheitis, chronic hepatitis, articular rheumatic pain, snake bite and insect sting, Herb is to the esophageal carcinoma, breast carcinoma, rectal cancer.Bulbus Lilii is the root of perennial herb bulbous plant drying.Sweet; Micro-hardship; Be slightly cold.The heart; Lung meridian.Nourishing YIN and moistening the lung; Clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough; Sputum mixed with blood; The calentura later stage; Waste heat is clear, or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will, insomnia and dreamful sleep, absentminded; Carbuncle; Eczema.Semen Coicis is the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. mayuen. (Roman.) Stapf, sweet, light, be slightly cold, for cancer and the multiple wart such as diarrhea due to hypofunction of the spleen edema beriberi, leucorrhea, wet, arthralgia, acute appendicitis, consumptive lung disease, gastric cancer, cervical cancer, chorionic epithelioma.Rhizoma Polygonati is (formal name used at school: Polygonatum sibiricum), is the root of Rhizoma Polygonati section plant drying.For spleen reinforcing, the lung moistening and production of body fluid promoting.Rhizoma Chuanxiong (formal name used at school: Ligusticum chuanxiong hort) is a kind of root of Chinese medicinal plant drying, and acrid in the mouth is warm in nature, return liver, gallbladder, heart channel, gas perfume rises loose, blood-activating and qi-promoting, wind-expelling pain-stopping, for menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia is suffered from abdominal pain, lump, heart pain in chest and hypochondrium, traumatic injury swells and ache, headache vertigo and head dark, anemofrigid-damp arthralgia, numb limbs and tense tendons, ulcer sores.Radix Sophorae Tonkinensis is the dry root and rhizome of leguminous plant Sophora tonkinensis Gagnep. Sophora tonkinensis Gapnep., bitter, cold, and for retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis.Radix Salviae Miltiorrhizae is the root of dicotyledon Labiatae drying, and nature and flavor are bitter, are slightly cold, GUIXIN, Liver Channel, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness, for menoxenia, and amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Eupolyphaga Seu Steleophaga is the entirety of the female worm drying of Corydiidae insecticide eupolyphoge sinensis Eupolyphaga sinensis Walker or Ji eupolyphoge sinensis Stelephaga plancyi (Boleny), cold in nature, salty in the mouth; Slightly poisonous, for removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones, for injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.Radix Curcumae is the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val., pungent, bitter, cold in nature.Return liver, the heart, lung meridian, regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood.For promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs, controls all pains of breast abdomen side of body rib, loses the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Radix Rhapontici is feverfew centaurea monanthos Georgi Rhaponticum uni-florum(L.) root of DC. or Radix Echinopsis Echinps latifolius Tausch. drying, bitter in the mouth is salty, cold, enters stomach, large intestine channel.Heat-clearing and toxic substances removing, evacuation of pus is subsided a swelling, and eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation, and swells and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.Radix Clematidis is cohosh Radix Clematidis, Clematis hexapetala, northeast clematis, and the rhizome of its drying can do medicine, pungent, salty, temperature, poisonous, return urinary bladder channel, for gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati Solanum lyratumThunb. drying, bitter, flat, slightly poisonous, clearing away heat-damp and promoting diuresis, and removing toxic substances and promoting subsidence of swelling is anticancer.Herba Solani Nigri is the dry Herb of plant of Solanaceae, and Herb: bitter is cold, slightly poisonous, heat clearing away, and removing toxic substances, invigorates blood circulation, detumescence; Root: bitter, micro-sweet, cold, Herb is used for furuncle, carbuncle, erysipelas, osteopatia sprain, chronic cough phlegm dyspnea, edema, cancerous protuberance; Root is used for dysentery, stranguria with turbid discharge, leukorrheal diseases, traumatic injury.Herba Hedyotidis Diffusae is the Herb of Rubiaceae drying, bitter, light, cold in nature.For heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Herba Scutellariae Barbatae, has another name called Portulaca grandilora, is the dry herb of Labiatae, pungent, flat, for heat-clearing and toxic substances removing, and blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.; External is controlled pain furuncle and is treated, treating swelling and pain by traumatic injury.Radix Notoginseng powder is the rhizome goods of plant Radix Notoginseng (formal name used at school: Panax pseudo-ginseng), temperature, micro-hardship.Enter liver, stomach, large intestine channel, for diabetes, hypertension, cardiovascular.
The traditional Chinese medical science is thought: excessive worry and anxiety impairing the heart spleen, depressed rage impairing the liver, and meridians painful abdominal mass plug, forms core block; Or pathogenic wind when four, visitor in meridians, addiction and in, tumor cellulitis given birth to; Surfeit delicious food, in alcoholism stays, often how dysphagic; Or positive QI-insufficiency, internal organs are weak, expectorant stasis of blood in bulk, raw in evil poison.In view of this, being monarch with dry maxima skin detoxicating and resolving stagnation of pathogens, is minister with Carapax Trionycis, Rhizoma Curcumae, Rabdosia rubescens hard masses softening and resolving, reducing swelling and alleviating pain; Assistant is with Radix Sophorae Tonkinensis, Radix Rhapontici, Herba Solani Lyrati, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae heat-clearing and toxic substances removing; Assistant is with Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Eupolyphaga Seu Steleophaga, Radix Notoginseng powder blood circulation promoting and blood stasis dispelling, removing obstruction for relieving pain; Help and calm the nerves with Rhizoma Polygonati, Bulbus Lilii, Semen Coicis strengthening vital QI to eliminate pathogenic factors, dehumidifying; With logical 12 warps of Radix Clematidis dampness removing for making; We collect hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors method in a side, when making unguentum, more modulate all medicines with Mel, prescription is shot the arrow at the target, and medicine compatibility is precise and penetrating, the cream side of can yet be regarded as a first treatment sucutaneous nodule lump, lump in the abdomen mass beside the umbilicus.
In medical material of the present invention, Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, containing volatile oil component in Herba Scutellariae Barbatae medical material, if directly the effective ingredient volatile oil decocted wherein can vapor away, cause the loss of effective ingredient, therefore the present invention adopts a Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae first extracts volatile oil, again the medicinal residues extracted after volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae decocts extraction together with Herba Solani Lyrati.The curative effect of medicine can be guaranteed.
Applicant is to invention has been large quantifier elimination, as follows:
experimental example 1: effect experiment
1, Experimental agents, animal and equipment
Medicine and reagent: medicine of the present invention (being prepared according to the method for the embodiment of the present invention 1), 5-fluorouracil (5-FU, Tianjin KingYork Amino Acid Co., Ltd.); Methyl thiazoly tetrazolium assay (MTT), dimethyl sulfoxide (DMSO), be Beijing Ding Guo biotech company product; RPMI1640 culture medium, trypsin GIBCO company).
Tumor strain and animal: mouse bearing liver cancer H22 cell strain, introduced by institute of materia medica of China Medical institute; BALB/C mice, body weight 18-21g, female, provided by Guiyang Medical College.
Instrument: DNM-9602 type enzyme-linked immunosorbent assay instrument (Beijing Pu Lang company); EPICSXL stream type cell analyzer (Beckman Coulter company of the U.S.); CO2 incubator (Forma Scientific company of the U.S.).
2, experimental technique
The inhibitory action of 2.1 pairs of mouse bearing liver cancers: adopt Murine Hepatoma22 cell strain, is inoculated in the right front axil of BALB/C mice after dilution according to a conventional method subcutaneous, often only inoculates 0.2mL, cause bearing mouse model; After inoculation 24h, they are divided at random medicine high dose group of the present invention, middle dosage group and low dose group; 5-FU matched group (5-FU group), model control group (model group), often organize 10 by totally 5 groups.Medicine group gastric infusion (dosage is in table 1), daily 1 time, continuous 10d; Model group gives normal saline gavage; 5-FU group starts administration, lumbar injection 1 time/d, continuous 5d in the 5th day after inoculated tumour.Each group of mice all after drug withdrawal next day take off neck and put to death, eyeball gets blood, separation of serum, strips tumor tissues and weighs, be calculated as follows tumour inhibiting rate, the results are shown in Table 1.
Note: with model group ratio, *p < 0.05, *p < 0.001.
2.2, on the impact of tumor-bearing mice time-to-live: get 50 mices, adopt the dosage regimen with 2.1, and carry out parallel test with identical condition, normally raise after drug withdrawal, observe and record each group of mouse diing time and mice Average Survival natural law, be calculated as follows increase in life span, the results are shown in Table 2.
Note: with model group ratio, *p < 0.05, *p < 0.001.
2.3, tumor-bearing mice is caused to the inhibitory action of hepatic metastases: put to death mice, take out liver, statistics hepatic metastases tuberosity average, is calculated as follows metastasis rate, the results are shown in Table 3.
Note: with model group ratio, *p < 0.05, *p < 0.001.
Conclusion: from above three experimental results: compare with model group, each treatment group tumor heavily has significant difference (P<0.0l and P<0.05); Mice band tumor life span obviously extends (P<0.0l and P<0.05); To H 22the subcutaneous inhibitory action causing hepatic metastases of tumor strain Mice Inoculated, high dose group compares with 5-FU group significant difference (P<0.05).Visible medicine of the present invention has obvious tumor-inhibiting action, can extend the life span of tumor-bearing mice, the transfer of Tumor suppression.
experimental example 2: toxicological experiment
Single gavage (284g/kg, 241g/kg, 205g/kg, 174g/kg, 148g/kg) and equal-volume purified water in KM mice 24 hours, administration capacity is 0.2ml/10g body weight (medicine is prepared according to the method for embodiment 1), Continuous Observation 14 days after administration, recording its LD50 is 388 times that 194g/kg(is equivalent to clinical dosage 0.5g/kg), its 95% credibility interval 171 ~ 216g/kg, to 24 hours after administration, mice autonomic activities weakens, alarm hair, appetite declines, recover after 24 hours.The death of mice occurs in administration to the 3rd day after 2 hours, and dead animal when dissected finds flatulence, hyperemia, all the other internal organs no abnormality seens.Non-dead animal observes 14 days, within every 7 days, weighs, and the growth of each group average weight has no notable difference, sacrifice of animal, dissects, perusal main organs no abnormality seen.
Compared with prior art, the present invention selects Carapax Trionycis, Rhizoma Curcumae, dry maxima skin, Rabdosia rubescens, Bulbus Lilii, Semen Coicis, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Sophorae Tonkinensis, Radix Salviae Miltiorrhizae, Eupolyphaga Seu Steleophaga, Radix Curcumae, Radix Rhapontici, Radix Clematidis, Herba Solani Lyrati, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Notoginseng powder and adjuvant to be prepared from.There is hard masses softening and resolving, the effect of (nourishing yin and activating blood, eliminating stagnation Disorder) is invigorated blood circulation in removing toxic substances.Be applicable to subcutaneous nodule, phlegm-damp oozing in the body, Ti Nei mass in the abdomen, all kinds of cancers, pernicious, the benign tumors of western medicine diagnosis.The curative effect of medication made is remarkable, and toxic and side effects is little, reaches goal of the invention.
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
detailed description of the invention:
Embodiment 1:
Prescription: by Carapax Trionycis 500g, Rhizoma Curcumae 1000g, dry maxima skin 300g (about 6), Rabdosia rubescens 500g, Bulbus Lilii 500g, Semen Coicis 1000g, Rhizoma Polygonati 1000g, Rhizoma Chuanxiong 500g, Radix Sophorae Tonkinensis 500g, Radix Salviae Miltiorrhizae 500g, Eupolyphaga Seu Steleophaga 400g, Radix Curcumae 400g, Radix Rhapontici 250g, Radix Clematidis 300g, Herba Solani Lyrati 200g, Herba Solani Nigri 200g, Herba Hedyotidis Diffusae 400g, Herba Scutellariae Barbatae 400g, Radix Notoginseng powder 500g.
Technique: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add the Mel of extractum amount 20%, agitating heating, when being concentrated into 60-65 DEG C, relative density is the extractum of 1.2-1.25, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, mixing, obtains soft extract.
Usage and dosage: oral, sooner or later respectively once (before or after meals), each 15g(is spoonful), put into hot water and melt rear oral; Also can directly swallow.
Embodiment 2:
Prescription: by Carapax Trionycis 600g, Rhizoma Curcumae 1000g, dry maxima skin 300g, Rabdosia rubescens 500g, Bulbus Lilii 500g, Semen Coicis 1000g, Rhizoma Polygonati 1000g, Rhizoma Chuanxiong 500g, Radix Sophorae Tonkinensis 400g, Radix Salviae Miltiorrhizae 500g, Eupolyphaga Seu Steleophaga 400g, Radix Curcumae 400g, Radix Rhapontici 250g, Radix Clematidis 300g, Herba Solani Lyrati 200g, Herba Solani Nigri 200g, Herba Hedyotidis Diffusae 400g, Herba Scutellariae Barbatae 400g, Radix Notoginseng powder 500g.
Technique: get dry maxima skin and be ground into fine powder, for subsequent use, separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use, extract the medicinal residues after volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add above-mentioned Bufo siccus corium farinosum again, volatile oil and Radix Notoginseng powder, and the dextrin of the amount of making 10% and 0.5% magnesium stearate mix homogeneously, with the alcohol granulation of 65%, dry, granulate, load capsule, obtain capsule.
Usage and dosage: oral, one time 3,3 times on the one.
Embodiment 3:
By Carapax Trionycis 500g, Rhizoma Curcumae 1000g, dry maxima skin 400g, Rabdosia rubescens 400g, Bulbus Lilii 500g, Semen Coicis 1000g, Rhizoma Polygonati 1000g, Rhizoma Chuanxiong 500g, Radix Sophorae Tonkinensis 500g, Radix Salviae Miltiorrhizae 500g, Eupolyphaga Seu Steleophaga 400g, Radix Curcumae 400g, Radix Rhapontici 250g, Radix Clematidis 300g, Herba Solani Lyrati 200g, Herba Solani Nigri 200g, Herba Hedyotidis Diffusae 300g, Herba Scutellariae Barbatae 400g, Radix Notoginseng powder 500g.
Technique: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, and the starch of the amount of making 20% and 1% magnesium stearate mixing, tabletting, coating, obtains tablet.
Usage and dosage: oral, one time 3,3 times on the one.

Claims (10)

1. treat the medicine of tumor for one kind, it is characterized in that: component calculates by weight, is prepared from by Carapax Trionycis 30-80 part, Rhizoma Curcumae 80-120 part, dry maxima skin 20-40 part, Rabdosia rubescens 30-80 part, Bulbus Lilii 30-80 part, Semen Coicis 80-120 part, Rhizoma Polygonati 80-120 part, Rhizoma Chuanxiong 30-80 part, Radix Sophorae Tonkinensis 30-80 part, Radix Salviae Miltiorrhizae 30-80 part, Eupolyphaga Seu Steleophaga 20-60 part, Radix Curcumae 20-60 part, Radix Rhapontici 10-50 part, Radix Clematidis 10-50 part, Herba Solani Lyrati 10-30 part, Herba Solani Nigri 10-30 part, Herba Hedyotidis Diffusae 20-60 part, Herba Scutellariae Barbatae 20-60 part, Radix Notoginseng powder 30-80 part and adjuvant.
2. treat the medicine of tumor as claimed in claim 1, it is characterized in that: be prepared from by Carapax Trionycis 50 parts, Rhizoma Curcumae 100 parts, dry maxima skin 30 parts, Rabdosia rubescens 50 parts, Bulbus Lilii 50 parts, Semen Coicis 100 parts, Rhizoma Polygonati 100 parts, Rhizoma Chuanxiong 50 parts, Radix Sophorae Tonkinensis 50 parts, Radix Salviae Miltiorrhizae 50 parts, Eupolyphaga Seu Steleophaga 40 parts, Radix Curcumae 40 parts, Radix Rhapontici 25 parts, Radix Clematidis 30 parts, Herba Solani Lyrati 20 parts, Herba Solani Nigri 20 parts, Herba Hedyotidis Diffusae 40 parts, Herba Scutellariae Barbatae 40 parts, Radix Notoginseng powder 50 parts and adjuvant.
3. treat the preparation method of the medicine of tumor as claimed in claim 1 or 2, it is characterized in that: according to all medicines in the prescription ratio side of taking, combine with acceptable pharmaceutic adjuvant in medicine, and preparation method is conveniently processed, make corresponding pharmaceutical preparation.
4. treat the preparation method of the medicine of tumor as claimed in claim 3, it is characterized in that: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 0.5-2h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Extract soak by water 2-3 time that the medicinal residues after volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati add 6-8 times amount jointly, each 0.5-2h, three times decocting liquid filters, merge, be condensed into extractum, then add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder, mixing, mix with conventional pharmaceutical adjuvants, more conventionally make different pharmaceutical preparation.
5. treat the preparation method of the medicine of tumor as claimed in claim 4, it is characterized in that: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, the extractum of the 1.10-1.15 that relative density is when being condensed into 60-65 DEG C, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, mixing, mix with conventional pharmaceutical adjuvants, more conventionally make different pharmaceutical preparation.
6. according to any one of claim 3-5, treat the preparation method of the medicine of tumor, it is characterized in that: described pharmaceutical preparation is soft extract, capsule, ointment, tablet, granule, pill, powder, sublimed preparation, plaster, cream or patch.
7. treat the preparation method of the medicine of tumor as claimed in claim 6, it is characterized in that: described pharmaceutical preparation is soft extract, capsule, granule or tablet.
8. treat the preparation method of the medicine of tumor as claimed in claims 6 or 7, it is characterized in that: described soft extract is prepared like this: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add the Mel of extractum amount 20%, agitating heating, when being concentrated into 60-65 DEG C, relative density is the extractum of 1.2-1.25, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, mixing, to obtain final product.
9. the preparation method of the medicine of soft treatment tumor as claimed in claims 6 or 7, is characterized in that: described capsule is prepared like this: get dry maxima skin and be ground into fine powder, for subsequent use; Separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use; Medicinal residues after extraction volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add above-mentioned Bufo siccus corium farinosum, volatile oil and Radix Notoginseng powder again, and the dextrin of the amount of making 10% and 0.5% magnesium stearate mix homogeneously, with the alcohol granulation of 65%, dry, granulate, load capsule, to obtain final product.
10. treat the preparation method of the medicine of tumor as claimed in claims 6 or 7, it is characterized in that: described granule is prepared like this: get dry maxima skin and be ground into fine powder, for subsequent use, separately get Rhizoma Curcumae, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rhapontici, Radix Clematidis, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae employing steam distillation extraction 1h, collect condensed fluid, stratification, isolates volatile oil, for subsequent use, extract the medicinal residues after volatile oil and Carapax Trionycis, Rabdosia rubescens, Semen Coicis, Radix Sophorae Tonkinensis, Eupolyphaga Seu Steleophaga, Radix Curcumae and Herba Solani Lyrati decoct with water 3 times jointly, first time adds 8 times amount soak by water 2h, second time adds 8 times amount soak by water 1 hour, third time adds 6 times amount soak by water 0.5 hour, collecting decoction, when being condensed into 60-65 DEG C, relative density is the extractum of 1.10-1.15, add above-mentioned Bufo siccus corium farinosum again, volatile oil and Radix Notoginseng powder, and the dextrin of the amount of making 15% and 15% sucrose mixing mixing, be wetting agent granule with 85% ethanol, 60 DEG C of dryings, after 12 mesh sieve 1 time, and separate fine powder with 60 mesh sieves, obtain.
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104826012A (en) * 2015-05-07 2015-08-12 董春霞 Traditional Chinese medicine preparation for pituitary tumor surgery postoperative nursing and preparation method thereof
CN105147920A (en) * 2015-09-21 2015-12-16 贵阳中医学院 Medicine used for treating tumors and preparation method thereof
CN105833220A (en) * 2016-04-22 2016-08-10 中国人民解放军第二军医大学 Traditional Chinese medicine composition for assistant treatment of gynecologic malignant tumors
CN106177790A (en) * 2016-08-29 2016-12-07 王建斌 A kind of capsule treating tumor and preparation method thereof
CN107375752A (en) * 2017-08-09 2017-11-24 裴然 A kind of Chinese medicine and boiling method of effectively treatment tumour
CN112870267A (en) * 2021-02-26 2021-06-01 荆文斌 New medicine for treating tumor and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
卫蓉等: "刘尚义教授巧用对药抗肿瘤的体会", 《贵阳中医学院学报》 *
郭士全等: "克木汤治疗原发性肝癌63例临床观察", 《徐州医学院学报》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104826012A (en) * 2015-05-07 2015-08-12 董春霞 Traditional Chinese medicine preparation for pituitary tumor surgery postoperative nursing and preparation method thereof
CN105147920A (en) * 2015-09-21 2015-12-16 贵阳中医学院 Medicine used for treating tumors and preparation method thereof
CN105833220A (en) * 2016-04-22 2016-08-10 中国人民解放军第二军医大学 Traditional Chinese medicine composition for assistant treatment of gynecologic malignant tumors
CN105833220B (en) * 2016-04-22 2019-11-08 中国人民解放军第二军医大学 A kind of Chinese medicine composition and purposes assisting in the treatment of gynecologic malignant tumor
CN106177790A (en) * 2016-08-29 2016-12-07 王建斌 A kind of capsule treating tumor and preparation method thereof
CN107375752A (en) * 2017-08-09 2017-11-24 裴然 A kind of Chinese medicine and boiling method of effectively treatment tumour
CN112870267A (en) * 2021-02-26 2021-06-01 荆文斌 New medicine for treating tumor and preparation method thereof

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