CN104547945A - Traditional Chinese medicine preparation for treating scrofula and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating scrofula and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating scrofula, belonging to the field of traditional Chinese medicine. The Traditional Chinese medicine preparation is prepared from the following raw materials: poria, sun euphorbia herb, rhizoma atractylodis, semen coicis, rhizoma polygonati, radix curcumae, spica prunellae, rhizoma arisaematis, semen sinapis albae, fructus aurantii, thallus laminariae, radix scrophulariae, radix astragali seu hedysari, radix angelicae dahuricae, oyster shell, rhizoma et radix notopterygii and radix glycyrrhizae. Compared with the prior art, the traditional Chinese medicine preparation has the therapeutic advantages of good treatment effect, no surgeries, treatment of both diseases and root causes, combination of regulation and treatment and the like, and also has the technical advantages that the preparation technology is convenient and easy, the medical effect is stable, the individual therapeutical effect difference is less, and the popularization is easy, and the like.
Description
Technical field
The present invention relates to one and treat scrofulous Chinese medicine preparation and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Lymphoid tuberculosis, the traditional Chinese medical science is referred to as scrofula, is the malicious block organization being embodied in flesh table, is to be condensed into by the scorchingly hot poison of expectorant of liver lung two aspect.Doctor trained in Western medicine then refers to, specializes in detoxicating virus killing thus protection blood vessel, the lymphsystem of tissue, meets with ex vivo and cannot remove the toadstool killed, condense and assemble the malignant tumor formed in flesh table organization in human body.
Doctor trained in Western medicine many employings injection of antibiotics or operative treatment, wound is large, side effect is large, and therapeutic effect neither be very desirable.
The traditional Chinese medical science is thought, many being pented up through wind heat gas poison by three Jiao, liver, gallbladder etc. of scrofula incidence forms, and Liver and kidney two, through deficiency of both QI and blood, caused by dynamic in asthenic fire, can be divided into acute, chronic two classes.Acute many because of affection due to external wind and heat, in accumulate expectorant poison and send out; Because the stagnation of QI, void are hindered and sent out more than chronic.This disease is often enraged angry strongly fragrant, and it is unsuccessful to consider, and spirit is downcast.
Summary of the invention
The technical problem to be solved in the present invention is a kind of Chinese medicine lymphoid tuberculosis being had to better therapeutic effect of exploitation, and utilizes modern pharmaceutical technology to evade Chinese medicine to take the shortcomings such as inconvenience, curative effect individual variation are large.
For solving this technical problem, inventor's foundation traditional Chinese medical science is to scrofulous dialectical theory, the feature of experience and the modern pharmaceutical technology of practising medicine in conjunction with self traditional Chinese medical science for many years, reasonable compatibility medical material, through checking and the adjustment of clinical practice, a final invention Chinese prescription and a set of preparation technology Chinese prescription being made the Chinese medicine preparation facilitating clinical practice, said preparation stable curative effect, general strong adaptability, has very significant therapeutic effect to lymphoid tuberculosis.This Chinese prescription is (with parts by weight):
Poria 9-19 part, Herba Euphorbiae Helioscopiae 6-12 part, Rhizoma Atractylodis 12-24 part, Semen Coicis 18-32 part, Rhizoma Polygonati 17-29 part, Radix Curcumae 6-13 part, Spica Prunellae 15-27 part, Rhizoma Arisaematis 10-22 part, Semen Sinapis Albae 7-17 part, Fructus Aurantii 7-15 part, Thallus Laminariae (Thallus Eckloniae) 20-32 part, Radix Scrophulariae 9-19 part, Radix Astragali 9-21 part, Radix Angelicae Dahuricae 8-18 part, Concha Ostreae 11-23 part, Rhizoma alpiniae chinensis 6-16 part, Radix Glycyrrhizae 8-12 part.
3 preferred prescriptions are respectively (with parts by weight):
Preferably 1: 14 parts, Poria, Herba Euphorbiae Helioscopiae 9 parts, Rhizoma Atractylodis 18 parts, Semen Coicis 25 parts, Rhizoma Polygonati 23 parts, Radix Curcumae 9 parts, Spica Prunellae 21 parts, Rhizoma Arisaematis 16 parts, Semen Sinapis Albae 12 parts, Fructus Aurantii 11 parts, Thallus Laminariae (Thallus Eckloniae) 26 parts, Radix Scrophulariae 14 parts, the Radix Astragali 15 parts, the Radix Angelicae Dahuricae 13 parts, Concha Ostreae 17 parts, Rhizoma alpiniae chinensis 11 parts, 10 parts, Radix Glycyrrhizae.
Preferably 2: 16 parts, Poria, Herba Euphorbiae Helioscopiae 10 parts, Rhizoma Atractylodis 17 parts, Semen Coicis 27 parts, Rhizoma Polygonati 22 parts, Radix Curcumae 8 parts, Spica Prunellae 23 parts, Rhizoma Arisaematis 17 parts, Semen Sinapis Albae 13 parts, Fructus Aurantii 12 parts, Thallus Laminariae (Thallus Eckloniae) 25 parts, Radix Scrophulariae 13 parts, the Radix Astragali 16 parts, the Radix Angelicae Dahuricae 15 parts, Concha Ostreae 15 parts, Rhizoma alpiniae chinensis 12 parts, 11 parts, Radix Glycyrrhizae.
Preferably 3: 15 parts, Poria, Herba Euphorbiae Helioscopiae 8 parts, Rhizoma Atractylodis 19 parts, Semen Coicis 26 parts, Rhizoma Polygonati 25 parts, Radix Curcumae 10 parts, Spica Prunellae 22 parts, Rhizoma Arisaematis 15 parts, Semen Sinapis Albae 11 parts, Fructus Aurantii 13 parts, Thallus Laminariae (Thallus Eckloniae) 28 parts, Radix Scrophulariae 15 parts, the Radix Astragali 14 parts, the Radix Angelicae Dahuricae 14 parts, Concha Ostreae 19 parts, Rhizoma alpiniae chinensis 13 parts, 11 parts, Radix Glycyrrhizae.
Preparation technology Chinese prescription of the present invention being made finished product preparation is:
(1) each taste Chinese crude drug is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 6-11 times of weight is added after mixing, backflow decoction three times, each 1-4 hour, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 7-12 times of weight is the ethanol of 65-75%, soak 10-18 hour, reflux, extract, 2 times, each 2-6 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made the Chinese medicine finished product preparation of clinical needs, as dosage forms such as tablet, pill, capsule, granule, powder, oral liquid, syrups.
The source of the present invention's Chinese crude drug used, meridian distribution of property and flavor and function:
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
Herba Euphorbiae Helioscopiae: Euphorbiaceae euphorbia Herba Euphorbiae Helioscopiae, with all herbal medicine.Acrid in the mouth, hardship, cold nature; Return lung, small intestinal, large intestine channel; Inducing diuresis to remove edema, dissipating phlegm and resolving masses, parasite killing.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. or Atractylis chinensis.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Semen Coicis: this product is the dry mature kernal of grass Semen Coicis.Sweet in the mouth, light, cool in nature; Return spleen, stomach, lung meridian; Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.
Rhizoma Polygonati: this product is the dry rhizome of liliaceous plant P. kingianum, Rhizoma Polygonati or Polygonatum cyrtonema Hua.Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Radix Curcumae: this product is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Acrid in the mouth, hardship, cold in nature; Return liver, the heart, lung meridian; Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Spica Prunellae: this product is the dry fruit ear of labiate Spica Prunellae.Acrid in the mouth, hardship, cold in nature; Return liver, gallbladder meridian; Relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.
Rhizoma Arisaematis: this product is the dry tuber of aroid Rhizoma Arisaematis, Arisaema heterophyllum B1. or arisaema amurense Maxim.Bitter in the mouth, pungent, warm in nature; Return lung, liver, spleen channel; Drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.
Semen Sinapis Albae: be the seed of crucifer Caulis et Folium Sinapis albee.Acrid in the mouth, warm in nature; Enter lung, stomach warp; Promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.
Fructus Aurantii: this product is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.Bitter in the mouth, pungent, sour, warm in nature; Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.
Thallus Laminariae (Thallus Eckloniae): this product is the dry thallus of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) or Alariaceae plant Thallus Laminariae (Thallus Eckloniae) (goose palm dish).Salty in the mouth, cold in nature; Return liver, stomach, kidney channel; Hard masses softening and resolving, expectorant, diuretic.
Radix Scrophulariae: this product is the dry root of goatweed Radix Scrophulariae.Sweet in the mouth, hardship, salty, cold nature; Return lung, stomach, kidney channel; Removing heat from blood YIN nourishing, eliminating fire and detoxication.
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali.Sweet in the mouth, warm in nature; Return lung, spleen channel; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae.Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
Concha Ostreae: this product is the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.Salty in the mouth, cold nature; Return liver, gallbladder, kidney channel; Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.
Rhizoma alpiniae chinensis: be the rhizome of zingiberaceous plant China Rhizoma Alpiniae Officinarum.Acrid in the mouth, warm in nature; Return spleen, stomach, Liver Channel; Warming middle-JIAO helps digestion, dispersing cold for relieving pain, invigorate blood circulation, relieving cough and asthma.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
This Chinese prescription is with Semen Coicis, Rhizoma Polygonati, Spica Prunellae, Thallus Laminariae (Thallus Eckloniae), Rhizoma Atractylodis for monarch drug, clearing away heat and discharging pus, boosting qi and nourishing yin, mass dissipating and swelling eliminating, softening the hard mass diuretic, drying damp and strengthening spleen; With Rhizoma Arisaematis, Concha Ostreae, Radix Scrophulariae, the Radix Astragali for ministerial drug, mass dissipating and swelling eliminating, hard masses softening and resolving, eliminating fire and detoxication, expelling pus and promoting granulation; With Herba Euphorbiae Helioscopiae, the Radix Angelicae Dahuricae, Semen Sinapis Albae, Fructus Aurantii for adjuvant drug, inducing diuresis to remove edema, understand things pain-stopping, warming spleen and stomach for dispelling cold, the stagnant relieving distension of row; With Poria, Radix Curcumae, Rhizoma alpiniae chinensis for making medicine, invigorating the spleen and regulating the stomach, heart fire-clearing upset-relieving, dispersing cold for relieving pain; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines are assisted each other, YIN and YANG balancing, jointly reach the effects such as clearing away heat and discharging pus, boosting qi and nourishing yin, mass dissipating and swelling eliminating, expelling pus and promoting granulation, understand things pain-stopping.Oral have very significant therapeutic effect to lymphoid tuberculosis.
Compared with prior art, Chinese medicine preparation of the present invention have therapeutic effect good, do not perform the operation, treating both the principal and secondary aspects of a disease, the treatment advantage such as medical treatment combination, and it also has, and preparation technology is simple and easy to do, efficacy stability, curative effect individual variation are little, be easy to technical advantages such as applying.
The toxicity test of Chinese medicine preparation of the present invention
1, basic document
Test drug: by Chinese medical concrete obtained by Chinese prescription of the present invention and preparation technology, add purified water and be modulated into magma.
Test animal used: regular grade NIH mice, body weight 21g ± 4g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 216 ± 10g, male and female half and half, female rats is all without pregnant.
2, acute toxicity test
Application mice carries out acute toxicity testing and shows: mouse stomach Chinese medicine magma of the present invention, under 773.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 2 hours recover normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach Chinese medicine magma of the present invention is 773.8g crude drug/kg/d(LD
50> 773.8g crude drug/kg).Chinese medicine preparation clinical application every day amount of the present invention is 0.25g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 3095.2 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
3, long term toxicity test
Select SD rat, give the Chinese medicine magma of the present invention of Three doses: 45g crude drug/kg, 15g crude drug/kg, 5g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to Pharmacopoeia of the People's Republic of China version in 2010).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.
Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (45g crude drug/kg, 15g crude drug/kg, 5g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.
Detailed description of the invention
Embodiment 1
Pill is made in Chinese medicine preparation prescription minimum zone ratio of the present invention:
(1) Poria 900g, Herba Euphorbiae Helioscopiae 600g, Rhizoma Atractylodis 1200g, Semen Coicis 1800g, Rhizoma Polygonati 1700g, Radix Curcumae 600g, Spica Prunellae 1500g, Rhizoma Arisaematis 1000g, Semen Sinapis Albae 700g, Fructus Aurantii 700g, Thallus Laminariae (Thallus Eckloniae) 2000g, Radix Scrophulariae 900g, Radix Astragali 900g, Radix Angelicae Dahuricae 800g, Concha Ostreae 1100g, Rhizoma alpiniae chinensis 600g, Radix Glycyrrhizae 800g is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 8 times of weight is added after mixing, backflow decoction three times, each 2 hours, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 9 times of weight is the ethanol of 70%, soak 15 hours, reflux, extract, 2 times, each 4 hours, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made pill, specification: amount to crude drug 0.375g/g pill.
Embodiment 2
Pill is made in Chinese medicine preparation prescription maximum magnitude ratio of the present invention:
(1) Poria 1900g, Herba Euphorbiae Helioscopiae 1200g, Rhizoma Atractylodis 2400g, Semen Coicis 3200g, Rhizoma Polygonati 2900g, Radix Curcumae 1300g, Spica Prunellae 2700g, Rhizoma Arisaematis 2200g, Semen Sinapis Albae 1700g, Fructus Aurantii 1500g, Thallus Laminariae (Thallus Eckloniae) 3200g, Radix Scrophulariae 1900g, Radix Astragali 2100g, Radix Angelicae Dahuricae 1800g, Concha Ostreae 2300g, Rhizoma alpiniae chinensis 1600g, Radix Glycyrrhizae 1200g is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 8 times of weight is added after mixing, backflow decoction three times, each 2 hours, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 9 times of weight is the ethanol of 70%, soak 15 hours, reflux, extract, 2 times, each 4 hours, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made pill, specification: amount to crude drug 0.375g/g pill.
Embodiment 3
Pill is made by arbitrary proportion within the scope of Chinese medicine preparation prescription of the present invention:
(1) Poria 900g, Herba Euphorbiae Helioscopiae 1200g, Rhizoma Atractylodis 1200g, Semen Coicis 3200g, Rhizoma Polygonati 1700g, Radix Curcumae 1300g, Spica Prunellae 1500g, Rhizoma Arisaematis 2200g, Semen Sinapis Albae 700g, Fructus Aurantii 1500g, Thallus Laminariae (Thallus Eckloniae) 2000g, Radix Scrophulariae 1900g, Radix Astragali 900g, Radix Angelicae Dahuricae 1800g, Concha Ostreae 1100g, Rhizoma alpiniae chinensis 1600g, Radix Glycyrrhizae 800g is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 8 times of weight is added after mixing, backflow decoction three times, each 2 hours, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 9 times of weight is the ethanol of 70%, soak 15 hours, reflux, extract, 2 times, each 4 hours, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made pill, specification: amount to crude drug 0.375g/g pill.
Embodiment 4
Pill is made in the ratio of the preferred prescription 1 of Chinese medicine preparation prescription of the present invention:
(1) Poria 1400g, Herba Euphorbiae Helioscopiae 900g, Rhizoma Atractylodis 1800g, Semen Coicis 2500g, Rhizoma Polygonati 2300g, Radix Curcumae 900g, Spica Prunellae 2100g, Rhizoma Arisaematis 1600g, Semen Sinapis Albae 1200g, Fructus Aurantii 1100g, Thallus Laminariae (Thallus Eckloniae) 2600g, Radix Scrophulariae 1400g, Radix Astragali 1500g, Radix Angelicae Dahuricae 1300g, Concha Ostreae 1700g, Rhizoma alpiniae chinensis 1100g, Radix Glycyrrhizae 1000g is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 8 times of weight is added after mixing, backflow decoction three times, each 2 hours, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 9 times of weight is the ethanol of 70%, soak 15 hours, reflux, extract, 2 times, each 4 hours, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made pill, specification: amount to crude drug 0.375g/g pill.
Embodiment 5
Pill is made in the ratio of the preferred prescription 2 of Chinese medicine preparation prescription of the present invention:
(1) Poria 1600g, Herba Euphorbiae Helioscopiae 1000g, Rhizoma Atractylodis 1700g, Semen Coicis 2700g, Rhizoma Polygonati 2200g, Radix Curcumae 800g, Spica Prunellae 2300g, Rhizoma Arisaematis 1700g, Semen Sinapis Albae 1300g, Fructus Aurantii 1200g, Thallus Laminariae (Thallus Eckloniae) 2500g, Radix Scrophulariae 1300g, Radix Astragali 1600g, Radix Angelicae Dahuricae 1500g, Concha Ostreae 1500g, Rhizoma alpiniae chinensis 1200g, Radix Glycyrrhizae 1100g is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 8 times of weight is added after mixing, backflow decoction three times, each 2 hours, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 9 times of weight is the ethanol of 70%, soak 15 hours, reflux, extract, 2 times, each 4 hours, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made pill, specification: amount to crude drug 0.375g/g pill.
Embodiment 6
Pill is made in the ratio of the preferred prescription 3 of Chinese medicine preparation prescription of the present invention:
(1) Poria 1500g, Herba Euphorbiae Helioscopiae 800g, Rhizoma Atractylodis 1900g, Semen Coicis 2600g, Rhizoma Polygonati 2500g, Radix Curcumae 1000g, Spica Prunellae 2200g, Rhizoma Arisaematis 1500g, Semen Sinapis Albae 1100g, Fructus Aurantii 1300g, Thallus Laminariae (Thallus Eckloniae) 2800g, Radix Scrophulariae 1500g, Radix Astragali 1400g, Radix Angelicae Dahuricae 1400g, Concha Ostreae 1900g, Rhizoma alpiniae chinensis 1300g, Radix Glycyrrhizae 1100g is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 8 times of weight is added after mixing, backflow decoction three times, each 2 hours, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 9 times of weight is the ethanol of 70%, soak 15 hours, reflux, extract, 2 times, each 4 hours, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made pill, specification: amount to crude drug 0.375g/g pill.
Chinese medicine preparation clinical trial of the present invention
1, physical data
This clinical trial is subject to the support energetically of certain the People's Hospital of city, all experimenters are all from this institute, and this institute accepts lymphoid tuberculosis patient 349 people for medical treatment altogether from year January in January, 2011 to 2014, therefrom select the patient 228 participating in clinical trial voluntarily, age 19-62 year, wherein man 120, female 108, all experimenters is age-based, sex, course of disease length etc. are divided into 4 groups, each group is made to have comparability on statistical significance, often organize 57 people, male 30 people, female 27 people; 4 groups are numbered respectively: matched group, test 4, test 5, test 6.
2, medication is tested
Contrast medicine: isoniazid tablets, specification: 50mg, authentication code: the accurate word H33021635 of traditional Chinese medicines, Hangzhou Minsheng Medcine Co., Ltd.
The pill that investigational agent: embodiment of the present invention 4-6 produces, specification: amount to 0.375g crude drug/g pill.
3, test method
The oral isoniazid tablets of matched group, every day 3 times, each 100mg, more than 5 hours, interval; Test 4, test 5, test 6 groups of pills respectively manufactured by oral embodiment of the present invention 4-6, every day 2 times, each 20g, amounts to crude drug 7.5g/ time.Within 3 weeks, be a course for the treatment of, treat 4 courses for the treatment of continuously.Record untoward reaction and recurrent cases.
4, result of the test judgment criteria
Cure: lymph lump or all symptoms of tuberculosis such as to fester disappear completely, and make a definite diagnosis through doctor and return to one's perfect health;
Effective: lymph lump obviously reduces, and festers and scabs, other related symptoms obviously alleviates;
Effective: scrofulous related symptoms is slightly improved or taken a turn for the better;
Invalid: scrofulous all symptoms are without any improvement, even more serious;
Recurrence: cure patient and again suffer from original disease in stopping administration within 6 months.
5, result of the test
(1) untoward reaction: matched group has the untoward reaction such as 12 routine patients have occurred instability of gait in various degree, numb prickling sensation, burn feeling, finger pain, peripheral neuritis, are off one's feed, abnormal weak, weak, Nausea and vomiting; None routine untoward reaction of 3 groups of test.
(2) result of the test statistical analysis:
After test all terminates, by as shown in table 1 for all data statistic analysis:
Table 1 test data statistical analysis table
6, conclusion (of pressure testing)
Compared with matched group: test group does not have untoward reaction case, matched group has 12 routine untoward reaction, and untoward reaction rate is up to 21.1%; The average cure rate of test group is 46.8%, higher than matched group 3.3 times; The average total effective rate of test group is 96.5%, higher than matched group 26.3 percentage points; No case was recurrence for test group, and matched group relapse rate is up to 37.5%.Therefore, Chinese medicine preparation of the present invention compared with prior art has treats advantage very significantly, obtains creationary achievement.
Claims (6)
1. treat a scrofulous Chinese medicine preparation, it is characterized in that being made up of the raw material of following weight portion: Poria 9-19 part, Herba Euphorbiae Helioscopiae 6-12 part, Rhizoma Atractylodis 12-24 part, Semen Coicis 18-32 part, Rhizoma Polygonati 17-29 part, Radix Curcumae 6-13 part, Spica Prunellae 15-27 part, Rhizoma Arisaematis 10-22 part, Semen Sinapis Albae 7-17 part, Fructus Aurantii 7-15 part, Thallus Laminariae (Thallus Eckloniae) 20-32 part, Radix Scrophulariae 9-19 part, Radix Astragali 9-21 part, Radix Angelicae Dahuricae 8-18 part, Concha Ostreae 11-23 part, Rhizoma alpiniae chinensis 6-16 part, Radix Glycyrrhizae 8-12 part.
2. one according to claim 1 treats scrofulous Chinese medicine preparation, it is characterized in that being made up of the raw material of following weight portion: 14 parts, Poria, Herba Euphorbiae Helioscopiae 9 parts, Rhizoma Atractylodis 18 parts, Semen Coicis 25 parts, Rhizoma Polygonati 23 parts, Radix Curcumae 9 parts, Spica Prunellae 21 parts, Rhizoma Arisaematis 16 parts, Semen Sinapis Albae 12 parts, Fructus Aurantii 11 parts, Thallus Laminariae (Thallus Eckloniae) 26 parts, Radix Scrophulariae 14 parts, the Radix Astragali 15 parts, the Radix Angelicae Dahuricae 13 parts, Concha Ostreae 17 parts, Rhizoma alpiniae chinensis 11 parts, 10 parts, Radix Glycyrrhizae.
3. one according to claim 1 treats scrofulous Chinese medicine preparation, it is characterized in that being made up of the raw material of following weight portion: 16 parts, Poria, Herba Euphorbiae Helioscopiae 10 parts, Rhizoma Atractylodis 17 parts, Semen Coicis 27 parts, Rhizoma Polygonati 22 parts, Radix Curcumae 8 parts, Spica Prunellae 23 parts, Rhizoma Arisaematis 17 parts, Semen Sinapis Albae 13 parts, Fructus Aurantii 12 parts, Thallus Laminariae (Thallus Eckloniae) 25 parts, Radix Scrophulariae 13 parts, the Radix Astragali 16 parts, the Radix Angelicae Dahuricae 15 parts, Concha Ostreae 15 parts, Rhizoma alpiniae chinensis 12 parts, 11 parts, Radix Glycyrrhizae.
4. one according to claim 1 treats scrofulous Chinese medicine preparation, it is characterized in that, described Chinese medicine preparation can also be made up of the raw material of following weight portion: 15 parts, Poria, Herba Euphorbiae Helioscopiae 8 parts, Rhizoma Atractylodis 19 parts, Semen Coicis 26 parts, Rhizoma Polygonati 25 parts, Radix Curcumae 10 parts, Spica Prunellae 22 parts, Rhizoma Arisaematis 15 parts, Semen Sinapis Albae 11 parts, Fructus Aurantii 13 parts, Thallus Laminariae (Thallus Eckloniae) 28 parts, Radix Scrophulariae 15 parts, the Radix Astragali 14 parts, the Radix Angelicae Dahuricae 14 parts, Concha Ostreae 19 parts, Rhizoma alpiniae chinensis 13 parts, 11 parts, Radix Glycyrrhizae.
5. prepare a method for the treatment of scrofulous Chinese medicine preparation as claimed in claim 1, it is characterized in that comprising following processing step:
(1) each taste Chinese crude drug is taken by Chinese prescription of the present invention;
(2) Poria, Herba Euphorbiae Helioscopiae, Rhizoma Atractylodis, Semen Coicis, Spica Prunellae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Angelicae Dahuricae, Concha Ostreae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are pulverized respectively, the purified water of 6-11 times of weight is added after mixing, backflow decoction three times, each 1-4 hour, filter, retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.18-1.23, for subsequent use;
(3) by Rhizoma Polygonati, Radix Curcumae, Rhizoma Arisaematis, Fructus Aurantii, Radix Scrophulariae, the Radix Astragali, pulverize respectively, after mixing with step (2) medicinal residues, the concentration adding 7-12 times of weight is the ethanol of 65-75%, soak 10-18 hour, reflux, extract, 2 times, each 2-6 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.18-1.23, for subsequent use;
(4) merged by concentrated solution obtained in step (2) and (3), mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, is Chinese medical concrete;
(5) add suitable adjuvant, utilize modern general Chinese medicine preparation technology, step (4) gained Chinese medical concrete is made the Chinese medicine finished product preparation of clinical needs.
6. one treats scrofulous Chinese medicine preparation as claimed in claim 1, it is characterized in that: described Chinese medicine preparation is tablet, pill, capsule, granule, powder, oral liquid or syrup.
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| CN105998600A (en) * | 2016-05-20 | 2016-10-12 | 贵州省镇远县陈天伦仁心苗医堂有限公司 | Scrofula treating traditional Chinese medicine preparation and preparing method thereof |
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