CN104547902A - Application of traditional Chinese preparation in preparation of drugs used for treating chronic enteritis and appendicitis - Google Patents
Application of traditional Chinese preparation in preparation of drugs used for treating chronic enteritis and appendicitis Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention belongs to the field of traditional Chinese medicine, and particularly relates to the application of a traditional Chinese preparation in preparation of drugs used for treating chronic enteritis and appendicitis. The traditional Chinese preparation mainly comprises the following raw materials: cordate houttuynia, oldenlandia diffusa, moutan bark, radix paeoniae rubra, coix seeds, peach seeds, rhizoma corydalis, rhizoma sparganii, spina gleditsiae, mirabilite, radix curcumae, selfheal, dandelion, cassia twig, radix aucklandiae, radix angelicae, licorice root and the like. The traditional Chinese preparation has the remarkable therapeutic advantages of being good in therapeutic effect, capable of treating both symptoms and root causes and low in possibility of recrudescence, combining recuperation and treatment and the like in the aspects of treating chronic enteritis and appendicitis, and further has the technical advantages of being simple and convenient in preparation technique, stable in drug efficacy, high in universality, easy for popularization and application and the like.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the preparation of the purposes in treatment chronic enteritis, appendicitis medicine.
Background technology
The enteritis that enteritis is antibacterial, virus, fungus and parasite etc. cause and colitis.Clinical manifestation mainly contains stomachache, diarrhoea, rare aquiform stool or mucus bloody purulent stool.Some patients can have heating and tenesmus sensation, therefore also known as infectious diarrhea.Enteritis is different by course of disease length, is divided into acute and chronic two classes.The chronic enteritis course of disease, generally more than two months, clinically common are chronic bacillary dysentery, chronic amebic dysentery, schistosomicide, nonspecific ulcerative colitis and limit office property enteritis etc.
The vermiform appendix chronic inflammatory conditions that chronic appendicitis is left over after referring to vermiform appendix acute inflammation subsides, as tube wall fibrous connective tissue hypertrophy, luminal stenosis or obturation, torsion of appendix, with surrounding tissue adhesion etc.Chronic appendicitis is divided into constitutional and Secondary cases 2 kinds.Primary chronic appendicitis onset is hidden, and symptom development is slow, and be interrupted outbreak, the course of disease continues longer, and some months was by several years.Sick just without typical acute attack history, also without the phenomenon of acute attack repeatedly in the course of disease.Subsequent chronic appendicitis is after acute appendicitis morbidity first, has left over clinical symptoms thereafter, obstinate through non-operative treatment more or spontaneous remission, can again or repeatedly acute attack in the course of disease.
Chronic enteritis be one of digestive system refractory disease clinical with the touching difficulty of recurrent exerbation more for its feature.The event still not fully aware of of pathogenic factor due to this disease is without the Therapeutic Method of specially good effect.The traditional Chinese medical science " diarrhea " category is belonged to according to its clinical manifestation chronic enteritis.Though this pathogenetic reason is many but be summed up three aspects:
1, weakness of the spleen and stomach
Many because of eating and drinking without temperance, surfeit is cold and cool, eating and drinking too much at one meal or overstrain, and emotion is not smooth, and melancholy impairing the spleen or being invaded by exogenous pathogen equivalent damage taste, damage of the spleen is abdominal distention after meal then, abdominal pain, defecates rare or has mucus, borborygmus falling inflation, and stomach hinders then anorexia.
2, the liver failing to dredge the spleen
The main catharsis of the liver belonging to wood, the main transporting of spleen pertaining to the earth.If mood is smooth at ordinary times, strongly fragrant worry of being worried, causes deficiency of liver-QI, can not catharsis spleen soil, and must affect the transportation capabilities of spleen, the traditional Chinese medical science is called " the liver failing to dredge the spleen ".Edema with the liver involved is not dredged, and lets out spleen soil, then insufficiency of the spleen mistake rises, and clearing heat in QI system is dirty, also diarrhea can occur.
3, YANG failing to warm spleen-YANG
The fire that the traditional Chinese medical science is said refers to kidney yang, and soil refers to taste.The transportation capabilities of spleen, except the catharsis of liver, also depend on the warm effect of kidney yang.This effect is called " the fire energy immature soil ".If the YANG QI deficiency of kidney, can not warm spleen soil, cause the receiving miopragia of taste, also diarrhea can occur.The traditional Chinese medical science is called " YANG failing to warm spleen-YANG ".The patient had clinically is when crowing just before dawn, and abdominal part is had a pain, pain and diarrhea, hands and feet being not warm, and this is caused by " YANG failing to warm spleen-YANG ".The disease of chronic enteritis many genus deficiency in origin and excess in superficiality, usually holds real appearance under the arm with apoplexy due to deficiency and occurs, but still based on insufficiency of the spleen.Therefore, also should start with from function of spleen and stomach regulating to its treatment, can treat with Jianpilichang side.
The traditional Chinese medical science to the typing of chronic appendicitis is:
1, stasis type
Clinical characters is qi depression to blood stasis mainly.Right lower abdomen has a dull ache, or distending pain, or dull pain, or twinge, or from the beginning of stomachache gastral cavilty place or around umbilicus have a pain and walk to alter indefinite.The heavy then localized pain of blood stasis, position at Right Lower Abdomen, sore spot tenderness or have enclosed mass.Gastral cavity abdominal distention can be had vexed, regurgitation of feeling sick, belch is indigestion and loss of appetite, and thermal image does not show, light red tongue, white and thin fur, stringy pulse or stringy and rolling pulse simultaneously, and constipation or normal, urinates clear or yellowish.
2, intrinsic heat type
The performance of its clinical characters mainly excess-heat or damp-heat accumulation.Have low grade fever or moderate heating, stomachache weighs and tenderness, and abdominal distention painful abdominal mass is vexed, nausea and vomiting, xerostomia thirst and desire for cold drink or not wish drink, constipation with dry stool or half congealed and not well, and yellowish urine is red or yellow turbid, wiry and frequent pulse or sliding number, red tongue or red tip of the tongue, dry, rough and yellow fur or yellow greasy.
3, scorchingly hot type
Be characterized in scorchingly hot flourishing phenomenon.Show as the high or fever with aversion to cold of heating, xerostomia is thirsty, and nausea and vomiting can not receive food, and Right Lower Abdomen or full stomachache weigh and tenderness, and flushing lip and tongue dryness, constipation due to dry stool, yellowish urine is few or red puckery, full and rapid pulse or stringy and rapid pulse, red tongue or red deep red, dry, rough and yellow fur.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine preparation for the preparation of the purposes in treatment chronic enteritis, appendicitis medicine, a kind of new Chinese medicine preparation is disclosed, make it have good therapeutic effect to chronic enteritis, appendicitis, and modern pharmaceutical technology can be utilized to make facilitate easy-to-use Chinese medicine preparation.
For solving the problems of the technologies described above, the solution of inventor is the feature in conjunction with modern pharmaceutical technology, according to drug matching principle, repeatedly adjusted by clinical practice, the Chinese prescription that final invention one is new, and invent the preparation technology matched with it, be made into the finished product preparation being convenient for carrying, being easy to use, efficacy stability.This Chinese prescription is (with parts by weight):
Herba Houttuyniae 13-27 part, Herba Hedyotidis Diffusae 13-27 part, Cortex Moutan 10-24 part, Radix Paeoniae Rubra 10-22 part, Semen Coicis 8-22 part, Semen Persicae 10-26 part, Rhizoma Corydalis 7-19 part, Rhizoma Sparganii 6-16 part, Spina Gleditsiae 11-25 part, Natrii Sulfas 5-15 part, Radix Curcumae 6-18 part, Spica Prunellae 5-15 part, Herba Taraxaci 7-23 part, Ramulus Cinnamomi 6-14 part, Radix Aucklandiae 5-13 part, Radix Angelicae Dahuricae 8-20 part, Radix Glycyrrhizae 6-16 part.
3 that optimize the in clinical practice proportionings with optimum therapeuticing effect are:
1, Herba Houttuyniae 20 parts, Herba Hedyotidis Diffusae 20 parts, Cortex Moutan 17 parts, Radix Paeoniae Rubra 16 parts, Semen Coicis 15 parts, 18 parts, Semen Persicae, Rhizoma Corydalis 13 parts, Rhizoma Sparganii 11 parts, Spina Gleditsiae 18 parts, 10 parts, Natrii Sulfas, Radix Curcumae 12 parts, Spica Prunellae 10 parts, Herba Taraxaci 15 parts, Ramulus Cinnamomi 10 parts, the Radix Aucklandiae 9 parts, the Radix Angelicae Dahuricae 14 parts, 11 parts, Radix Glycyrrhizae.
2, Herba Houttuyniae 22 parts, Herba Hedyotidis Diffusae 21 parts, Cortex Moutan 19 parts, Radix Paeoniae Rubra 15 parts, Semen Coicis 16 parts, 16 parts, Semen Persicae, Rhizoma Corydalis 15 parts, Rhizoma Sparganii 12 parts, Spina Gleditsiae 17 parts, 12 parts, Natrii Sulfas, Radix Curcumae 13 parts, Spica Prunellae 11 parts, Herba Taraxaci 17 parts, Ramulus Cinnamomi 11 parts, the Radix Aucklandiae 8 parts, the Radix Angelicae Dahuricae 15 parts, 12 parts, Radix Glycyrrhizae.
3, Herba Houttuyniae 21 parts, Herba Hedyotidis Diffusae 23 parts, Cortex Moutan 18 parts, Radix Paeoniae Rubra 15 parts, Semen Coicis 17 parts, 17 parts, Semen Persicae, Rhizoma Corydalis 14 parts, Rhizoma Sparganii 13 parts, Spina Gleditsiae 16 parts, 11 parts, Natrii Sulfas, Radix Curcumae 11 parts, Spica Prunellae 12 parts, Herba Taraxaci 16 parts, Ramulus Cinnamomi 12 parts, the Radix Aucklandiae 10 parts, the Radix Angelicae Dahuricae 12 parts, 12 parts, Radix Glycyrrhizae.
Preparation technology Chinese prescription being made Chinese medicine preparation is following steps:
(1), by Chinese prescription take ingredients respectively, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 6-9 times weight, soak 10-18 hour, backflow decocts 2-4 hour, filter, add the purified water of initial weight 5-8 times weight again, backflow decocts 1-3 hour, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 65-75% of 5-7 times of weight, reflux, extract, 2 times, each 2-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make the finished product preparation of clinical needs, as dosage forms such as oral liquid, tablet, pill, capsule, powder, granules.
Source, the nature and flavor of the present invention's Chinese crude drug used, return through and function:
Herba Houttuyniae: this product is the stem and leaf of saururaceae plant houttuynia cordata.Acrid in the mouth, cool in nature; Return lung meridian; Heat-clearing and toxic substances removing, skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion are treated in detumescence.
Herba Hedyotidis Diffusae: this product is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae.Sweet in the mouth, light, cool in nature; Enter stomach, large intestine, small intestine meridian; Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.
Cortex Moutan: this product is the dry root bark of ranunculaceae peony.Bitter in the mouth, pungent, cold nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.
Semen Coicis: this product is the dry mature kernal of grass Semen Coicis.Sweet in the mouth, light, cool in nature; Return spleen, stomach, lung meridian; Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.
Semen Persicae: this product is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana.Bitter in the mouth, sweet, property is put down; GUIXIN, liver, large intestine channel; Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
Rhizoma Corydalis: this product is the tuber of Papaveraceae, Corydalis herbaceos perennial.Acrid in the mouth, warm in nature; Enter the heart, liver, stomach, lung, spleen channel; Promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.
Rhizoma Sparganii: this product is the dry tuber of Sparganiaceae plant rhizoma scirpi.Acrid in the mouth, hardship, property is put down; Return liver, spleen channel; Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.
Spina Gleditsiae: this product is the dry Spina jujubae of leguminous plant Fructus Gleditsia.Acrid in the mouth, warm in nature; Return liver, stomach warp; Detumescence poison holding, evacuation of pus, parasite killing.
Natrii Sulfas: this product is Sulfates mineral Natrii Sulfas race Natrii Sulfas, through the crystalline solid of processing and refining.Salty in the mouth, hardship, cold in nature; Return stomach, large intestine channel; Purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.
Radix Curcumae: this product is the herbal rhizome of Curcuma perennial root.Acrid in the mouth, cold in nature; Return liver, lung, heart channel; Promoting blood circulation and stopping pain, regulating qi to disperse stagnation.
Spica Prunellae: this product is the dry fruit ear of labiate Spica Prunellae.Acrid in the mouth, hardship, cold in nature; Return liver, gallbladder meridian; Relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.
Herba Taraxaci: this product is feverfew Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herb of several plants together.Bitter in the mouth, sweet, cold in nature; Return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi.Acrid in the mouth, sweet, warm in nature; GUIXIN, lung, urinary bladder channel; Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians; Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae.Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention be with
Herba Houttuyniae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Cortex Moutan, Semen Persicae are monarch drug, eliminating carbuncle evacuation of pus, promoting blood circulation and stopping pain, detumescence poison holding, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; With Radix Paeoniae Rubra, Semen Coicis, Herba Taraxaci, the Radix Angelicae Dahuricae for ministerial drug, eliminating stasis to stop pain, eliminating impediment antidiarrheal, heat-clearing and toxic substances removing, loose wind dehumidifying; With Rhizoma Corydalis, Rhizoma Sparganii, Radix Curcumae, Natrii Sulfas for adjuvant drug, promoting blood circulation to restore menstrual flow, removing blood stasis circulation of qi promoting, wind-expelling pain-stopping, detumescence of relieving inflammation or internal heat; With Spica Prunellae, Ramulus Cinnamomi, the Radix Aucklandiae for making medicine, mass dissipating and swelling eliminating, promoting the flow of QI-blood by warming the meridian, strengthening the spleen to promote digestion; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicine of monarch is coordinated, synergism, jointly reach eliminating carbuncle pain relieving, heat-clearing and toxic substances removing, effects such as detumescence, promoting blood circulation to restore menstrual flow of relieving inflammation or internal heat, to chronic enteritis, appendicitis, there is significant therapeutic effect.
Compared with prior art, Chinese medicine preparation of the present invention is in treatment chronic enteritis, appendicitis, have that therapeutic effect is good, treating both the principal and secondary aspects of a disease, conditioning be combined with treatment, the not easily significant treatment advantage such as recurrence, and have that preparation technology is easy, efficacy stability, universality strong, be easy to technical advantages such as applying.
Detailed description of the invention
Embodiment 1
Produce by Chinese prescription proportion maximum of the present invention:
(1), take respectively by Chinese prescription: Herba Houttuyniae 2600g, Herba Hedyotidis Diffusae 2600g, Cortex Moutan 2300g, Radix Paeoniae Rubra 2100g, Semen Coicis 2100g, Semen Persicae 2500g, Rhizoma Corydalis 1800g, Rhizoma Sparganii 1500g, Spina Gleditsiae 2400g, Natrii Sulfas 1400g, Radix Curcumae 1700g, Spica Prunellae 1400g, Herba Taraxaci 2200g, Ramulus Cinnamomi 1300g, Radix Aucklandiae 1200g, Radix Angelicae Dahuricae 1900g, Radix Glycyrrhizae 1500g, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 7 times of weight, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 6 times of weight again, backflow decoction 2 hours, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 70% of 6 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make granule, amounting to crude drug content is 0.30g crude drug/g granule.
Embodiment 2
Produce by Chinese prescription proportion minima of the present invention:
(1), take respectively by Chinese prescription: Herba Houttuyniae 1400g, Herba Hedyotidis Diffusae 1400g, Cortex Moutan 1100g, Radix Paeoniae Rubra 1100g, Semen Coicis 900g, Semen Persicae 1100g, Rhizoma Corydalis 800g, Rhizoma Sparganii 700g, Spina Gleditsiae 1200g, Natrii Sulfas 600g, Radix Curcumae 700g, Spica Prunellae 600g, Herba Taraxaci 800g, Ramulus Cinnamomi 700g, Radix Aucklandiae 600g, Radix Angelicae Dahuricae 900g, Radix Glycyrrhizae 700g, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 7 times of weight, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 6 times of weight again, backflow decoction 2 hours, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 70% of 6 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make granule, amounting to crude drug content is 0.30g crude drug/g granule.
Embodiment 3
Produce by arbitrary value in Chinese prescription proportion of the present invention:
(1), take respectively by Chinese prescription: Herba Houttuyniae 1400g, Herba Hedyotidis Diffusae 2600g, Cortex Moutan 1100g, Radix Paeoniae Rubra 2100g, Semen Coicis 900g, Semen Persicae 2500g, Rhizoma Corydalis 800g, Rhizoma Sparganii 1500g, Spina Gleditsiae 1200g, Natrii Sulfas 1400g, Radix Curcumae 700g, Spica Prunellae 1400g, Herba Taraxaci 800g, Ramulus Cinnamomi 1300g, Radix Aucklandiae 600g, Radix Angelicae Dahuricae 1900g, Radix Glycyrrhizae 700g, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 7 times of weight, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 6 times of weight again, backflow decoction 2 hours, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 70% of 6 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make granule, amounting to crude drug content is 0.30g crude drug/g granule.
Embodiment 4
Produce by Chinese prescription optimum ratio 1 of the present invention:
(1), take respectively by Chinese prescription: Herba Houttuyniae 2000g, Herba Hedyotidis Diffusae 2000g, Cortex Moutan 1700g, Radix Paeoniae Rubra 1600g, Semen Coicis 1500g, Semen Persicae 1800g, Rhizoma Corydalis 1300g, Rhizoma Sparganii 1100g, Spina Gleditsiae 1800g, Natrii Sulfas 1000g, Radix Curcumae 1200g, Spica Prunellae 1000g, Herba Taraxaci 1500g, Ramulus Cinnamomi 1000g, Radix Aucklandiae 900g, Radix Angelicae Dahuricae 1400g, Radix Glycyrrhizae 1100g, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 7 times of weight, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 6 times of weight again, backflow decoction 2 hours, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 70% of 6 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make granule, amounting to crude drug content is 0.30g crude drug/g granule.
Embodiment 5
Produce by Chinese prescription optimum ratio 2 of the present invention:
(1), take respectively by Chinese prescription: Herba Houttuyniae 2200g, Herba Hedyotidis Diffusae 2100g, Cortex Moutan 1900g, Radix Paeoniae Rubra 1500g, Semen Coicis 1600g, Semen Persicae 1600g, Rhizoma Corydalis 1500g, Rhizoma Sparganii 1200g, Spina Gleditsiae 1700g, Natrii Sulfas 1200g, Radix Curcumae 1300g, Spica Prunellae 1100g, Herba Taraxaci 1700g, Ramulus Cinnamomi 1100g, Radix Aucklandiae 800g, Radix Angelicae Dahuricae 1500g, Radix Glycyrrhizae 1200g, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 7 times of weight, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 6 times of weight again, backflow decoction 2 hours, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 70% of 6 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make granule, amounting to crude drug content is 0.30g crude drug/g granule.
Embodiment 6
Produce by Chinese prescription optimum ratio 3 of the present invention:
(1), take respectively by Chinese prescription: Herba Houttuyniae 2100g, Herba Hedyotidis Diffusae 2300g, Cortex Moutan 1800g, Radix Paeoniae Rubra 1500g, Semen Coicis 1700g, Semen Persicae 1700g, Rhizoma Corydalis 1400g, Rhizoma Sparganii 1300g, Spina Gleditsiae 1600g, Natrii Sulfas 1100g, Radix Curcumae 1100g, Spica Prunellae 1200g, Herba Taraxaci 1600g, Ramulus Cinnamomi 1200g, Radix Aucklandiae 1000g, Radix Angelicae Dahuricae 1200g, Radix Glycyrrhizae 1200g, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 7 times of weight, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 6 times of weight again, backflow decoction 2 hours, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 70% of 6 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make granule, amounting to crude drug content is 0.30g crude drug/g granule.
Embodiment 7
The animal toxicity experiment of Chinese medicinal granule of the present invention
(1) test drug: Chinese medicine granules obtained by the embodiment of the present invention 1 to 6, adds purified water, is modulated into magma.
Test animal used: regular grade NIH mice, body weight 22g ± 6g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 218 ± 12g, male and female half and half, female rats is all without pregnant.
(2) acute toxicity test
Application mice carries out acute toxicity testing and shows: the magma of mouse stomach Chinese medicine granules preparation of the present invention, under 754.1g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1.5 hours recover normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of the magma of mouse stomach Chinese medicinal granule preparation of the present invention is 754.1g crude drug/kg/d(LD
50> 754.1g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.20g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 3770.5 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
(3), long term toxicity test
Select SD rat, give the Chinese medicine oral liquid of the present invention of Three doses: 36g crude drug/kg, 12g crude drug/kg, 4g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to Pharmacopoeia of the People's Republic of China version in 2010).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.
Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (36g crude drug/kg, 12g crude drug/kg, 4g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.
Embodiment 8
The anti-inflammation test of Chinese medicine granules of the present invention:
For the impact that abdominal cavity blood capillary permeability increases
1, trial drug
The made granule of embodiment of the present invention 4-6, amounting to crude drug content is 0.30g crude drug/g granule.
2, experimental animal
Regular grade NIH mice, body weight 20g ± 6g, male and female half and half, female mice is all without pregnant.
3, test method and result
By mice by after body weight random packet, gavage gives embodiment 4-6 made granule various dose and (is equivalent to 1 of clinical plan consumption respectively, 2, 4 times) modulation solution, matched group gives the distilled water of same volume, after 1 hour, tail vein injection 0.5% Evans blue liquid 0.2ml/10g mice, within 10 minutes, pneumoretroperitoneum only injects 0.8% glacial acetic acid 0.2ml/, animal is put to death after 20 minutes, lumbar injection 5ml normal saline, soft abdominal part, cut off osculum, draw peritoneal fluid, centrifuging and taking supernatant, densitometric value under wavelength 590nm, statistical procedures (see table 1) is carried out with t inspection.
Impact (n=11) that table 1 Chinese medicinal granule of the present invention increases mouse peritoneal capillary permeability (
± SD)
Note: * P < 0.05, * * P < 0.01 compared with matched group.
4, conclusion (of pressure testing)
Result is from table 1 result, and Chinese medicine preparation of the present invention can obviously suppress acetic acid to stimulate increasing of the mouse peritoneal capillary permeability caused.Wherein the made particle performance of embodiment 6 is particularly outstanding.
Embodiment 9
The clinical trial of Chinese medicinal granule of the present invention
From embodiment 8, the made particle effect of embodiment 6 is the most excellent, carries out clinical effectiveness test with the made granule of embodiment 6.
1, testing data
The experimenter of this experiment is provided by certain the People's Hospital of city, and this institute has accepted 520 chronic enteritiss, Appendicitis Patients for medical treatment altogether from June, 2010 to 2013 year December, therefrom selects patients having chronic intestinal inflammation 150, chronic appendicitis patients 130.
2, test grouping
All experimenters are divided into two groups by disease kind, divide into groups as shown in table 2.
Table 2 divides into groups catalog
| Sick kind | Number of cases | Man | Female | Age (year) | Average course of disease (year) |
| Chronic enteritis | 150 | 59 | 91 | 18-67 | 3.5 |
| Chronic appendicitis | 130 | 60 | 70 | 17-69 | 2.8 |
3, trial drug
Investigational agent: the granule that the embodiment of the present invention 6 is produced, amounting to crude drug content is 0.30g crude drug/g granule.
4, test method
The granule that the oral embodiment 6 of all experimenters is produced, every day 2 times, each 20g 4 weeks is a course for the treatment of, treats 4 courses for the treatment of continuously, pays a return visit healing person in drug withdrawal after 6 months, record recurrent cases.
5, evaluation criterion
Cure: chronic enteritis, appendicitis related symptoms disappear completely, and make a definite diagnosis through doctor and return to one's perfect health.
Effective: chronic enteritis, appendicitis related symptoms partial disappearance, still need continual cure.
Invalid: chronic enteritis, appendicitis related symptoms are without any improvement and take a turn for the better, even more serious.
Recurrence: original disease is again suffered from drug withdrawal in 6 months to the patient cured.
6, result of the test statistical analysis
After test all completes, by as shown in table 3 for test data statistical analysis:
Table 3 test data statistical analysis table
| Sick kind | Number of cases | Cure (rate) | Effectively | Invalid | Total effective rate | Recurrence (rate) |
| Chronic enteritis | 150 | 104（69.3%） | 45 | 1 | 99.3% | 4（3.8%） |
| Chronic appendicitis | 130 | 95（73.1%） | 32 | 3 | 97.7% | 3（3.2%） |
7, conclusion (of pressure testing)
From result of the test, Chinese medicine preparation of the present invention is all very high to chronic enteritis, typhlitic cure rate, total effective rate, and relapse rate is very low, illustrates that Chinese medicine preparation of the present invention has significant treatment advantage, obtains beyond thought technological achievement.
Claims (6)
1. Chinese medicine preparation is for the preparation of the purposes in treatment chronic enteritis, appendicitis medicine, and it is characterized in that, described Chinese medicine preparation is made up of the Chinese crude drug of following weight portion:
Herba Houttuyniae 13-27 part, Herba Hedyotidis Diffusae 13-27 part, Cortex Moutan 10-24 part, Radix Paeoniae Rubra 10-22 part, Semen Coicis 8-22 part, Semen Persicae 10-26 part, Rhizoma Corydalis 7-19 part, Rhizoma Sparganii 6-16 part, Spina Gleditsiae 11-25 part, Natrii Sulfas 5-15 part, Radix Curcumae 6-18 part, Spica Prunellae 5-15 part, Herba Taraxaci 7-23 part, Ramulus Cinnamomi 6-14 part, Radix Aucklandiae 5-13 part, Radix Angelicae Dahuricae 8-20 part, Radix Glycyrrhizae 6-16 part.
2. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is made up of the Chinese crude drug of following weight portion:
Herba Houttuyniae 20 parts, Herba Hedyotidis Diffusae 20 parts, Cortex Moutan 17 parts, Radix Paeoniae Rubra 16 parts, Semen Coicis 15 parts, 18 parts, Semen Persicae, Rhizoma Corydalis 13 parts, Rhizoma Sparganii 11 parts, Spina Gleditsiae 18 parts, 10 parts, Natrii Sulfas, Radix Curcumae 12 parts, Spica Prunellae 10 parts, Herba Taraxaci 15 parts, Ramulus Cinnamomi 10 parts, the Radix Aucklandiae 9 parts, the Radix Angelicae Dahuricae 14 parts, 11 parts, Radix Glycyrrhizae.
3. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is made up of the Chinese crude drug of following weight portion:
Herba Houttuyniae 22 parts, Herba Hedyotidis Diffusae 21 parts, Cortex Moutan 19 parts, Radix Paeoniae Rubra 15 parts, Semen Coicis 16 parts, 16 parts, Semen Persicae, Rhizoma Corydalis 15 parts, Rhizoma Sparganii 12 parts, Spina Gleditsiae 17 parts, 12 parts, Natrii Sulfas, Radix Curcumae 13 parts, Spica Prunellae 11 parts, Herba Taraxaci 17 parts, Ramulus Cinnamomi 11 parts, the Radix Aucklandiae 8 parts, the Radix Angelicae Dahuricae 15 parts, 12 parts, Radix Glycyrrhizae.
4. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is made up of the Chinese crude drug of following weight portion:
Herba Houttuyniae 21 parts, Herba Hedyotidis Diffusae 23 parts, Cortex Moutan 18 parts, Radix Paeoniae Rubra 15 parts, Semen Coicis 17 parts, 17 parts, Semen Persicae, Rhizoma Corydalis 14 parts, Rhizoma Sparganii 13 parts, Spina Gleditsiae 16 parts, 11 parts, Natrii Sulfas, Radix Curcumae 11 parts, Spica Prunellae 12 parts, Herba Taraxaci 16 parts, Ramulus Cinnamomi 12 parts, the Radix Aucklandiae 10 parts, the Radix Angelicae Dahuricae 12 parts, 12 parts, Radix Glycyrrhizae.
5. the purposes as described in as arbitrary in claim 1-4, it is characterized in that, the preparation technology of described Chinese medicine preparation is:
(1), by Chinese prescription take ingredients respectively, pulverize, for subsequent use;
(2), all medical materials are added the distilled water of initial medical material 6-9 times weight, soak 10-18 hour, backflow decocts 2-4 hour, filter, add the purified water of initial weight 5-8 times weight again, backflow decocts 1-3 hour, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3), the filtering residue of step (2) is added the ethanol of the concentration 65-75% of 5-7 times of weight, reflux, extract, 2 times, each 2-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4), by the concentrated solution of step (2) and (3) gained merge, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5), by the Chinese medical concrete of step (4) add adjuvant, utilize modern general Chinese medicine preparation technology to make the finished product preparation of clinical needs.
6. the purposes as described in as arbitrary in claim 1-4, it is characterized in that, described Chinese medicine preparation makes oral liquid, tablet, pill, capsule, powder and granule.
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