CN105288315A - Christina loosestrife herb oral liquid for clearing away heat, removing dampness, benefiting bile and expelling toxin and preparation method of christina loosestrife herb oral liquid - Google Patents

Abstract

The invention provides a christina loosestrife herb oral liquid for clearing away heat, removing dampness, benefiting the bile and expelling toxin. The christina loosestrife herb oral liquid is prepared from the following raw materials in parts by weight: 10-50 parts of christina loosestrife herb, 10-20 parts of herba artemisiae scopariae, 10-20 parts of poria cocos, 10-20 parts of selfheal, 10-20 parts of gardenia, 10-20 parts of dandelion, 10-20 parts of lophatherum gracile, 10-20 parts of corn stigma, 10-20 parts of loranthus parasiticus, 10-20 parts of eupatorium, 10-20 parts of fructus forsythia, 10-20 parts of radix isatidis, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of cortex moutan, 10-20 parts of oldenlandia diffusa, 10-20 parts of abrus cantoniensis hance, 10-20 parts of philippine flemingia roots, 10-20 parts of eyebright, 10-20 parts of purslane, 10-20 parts of endothelium corneum gigeriae galli, 10-20 parts of lentil and 10-20 parts of rhizoma atractylodis. The christina loosestrife herb oral liquid has relatively good effects of protecting the liver, benefiting the bile, removing dampness, losing weight and expelling toxin.

Description

Herba Lysimachiae oral liquid of a kind of removing damp-heat, function of gallbladder promoting toxin expelling and preparation method thereof

Technical field

The present invention relates to the medical health product containing deriving from plant, animal or raw mineral materials, particularly the Herba Lysimachiae oral liquid and preparation method thereof of a kind of removing damp-heat, function of gallbladder promoting toxin expelling.

Background technology

When registering the department of Chinese medicine, we often can listen doctor to say " damp and hot ".So, what is damp and hot, and damp and hot have which to show, what problem should be noted? understand damp and hot, first should be appreciated that what cries wet, what is heat.So-called wet, namely usually said water wets, and it has the differentiation of exogenous damp and endogenous dampness.Exogenous damp is drenched with rain owing to having a humid climate or paddling or room humidity, makes secondary water wet invasion human body and cause; Endogenous dampness is a kind of pathological product, normal relevant with digestive function.The traditional Chinese medical science thinks the function that spleen has " transmitting and distributing the fluids ", if the empty dyspepsia of body or eating and drinking too much at one meal, eats too much greasy, sweet food, then spleen just can not normal transporting and make " retention of water-damp in the body "; And insufficiency of the spleen people also easily causes the invasion of exogenous damp, exogenous damp is also normal to be made wet from interior life, so both are not only independent but also associate because hindering taste.So-called heat is then a kind of thermal image.And damp and hot in heat be with wet simultaneous, or because of the hot weight in wet base in summer and autumn sky, wetly invade human body with heat seal, or because of wet stay for a long time not except and heat-transformation, or make to wet " heat being transformed from excessive YANG " because of " positive hot body matter ", therefore, wet and hot to exist be very common simultaneously.Damp-heat constitution is facial and nose is always glossy shinny, easy fecula thorn, furuncle, and often feel bitter taste, halitosis or have abnormal flavour in the mouth, often stool viscous is not well, urine has heating to feel, and the jaundice of urine color, the normal leucorrhea with yellow discharge of women, males scrotum is moist hyperhidrosis always.Morbidity tendency: the people of damp-heat constitution easily suffers from furuncle, jaundice, burning hot disease etc. and levies.

Damp and hot generally shows as: limbs are heavy, and heating is many obviously afternoon, does not alleviate because of perspiration; Yellowish fur, rapid pulse.Concrete manifestation has difference because of different position, damp and hot place: be then eczema or furuncle bleb at skin and flesh; At joint muscle arteries and veins then partial gall.But usually said damp and hot finger damp and hotly gos deep into internal organs more, and particularly taste is damp and hot, the vexed abdominal distention of visible gastral cavity, anorexia of feeling sick, and loose stool is rare, and short urination is red, soft and rapid pulse; Other shows as liver pain as dampness-heat in the liver and gallbladder, and bitter taste appetite is poor, or the jaundice of body order, or heating is afraid of cold alternately, wiry and frequent pulse; Damp-heat in the urinary bladder is shown in frequent micturition, urgent micturition, less puckery and pain, yellow skin is turbid; Damp-heat in the large intestine is shown in abdominal pain diarrhea, even tenesmus, rushes down defecation with blood and pus just, burning sensation of the anus, thirsty.

Damp and hot treatment, generally will divide weight in wet base or thermogravimetric.The removing dampness of weight in wet base is main, can select LIUYI SAN, sanren decoction, Pingwei San; Thermogravimetric, based on heat clearing away, can select lianpu drink, Herba Artemisiae Scopariae Decoction, GEGEN QINLIAN TANG.Under this principle, then select corresponding medicine according to some Special Manifestations, as eczema, furuncle bleb, add Flos Chrysanthemi Indici, Herba Violae, Radix Sophorae Flavescentis, Cortex Dictamni; Arthralgia adds Ramulus Cinnamomi, Caulis Lonicerae, Ramulus Mori etc.; Even dysentery of suffering from diarrhoea adds Radix Pulsatillae Decoction, Radix Sanguisorbae, Semen Plantaginis etc.; Eczema scrotum, distending pain of the testis, leucorrhea are yellow smellyly adds Radix Gentianae, Radix Sophorae Flavescentis etc.; Hematuria can add HERBA CIRSII, Rhizoma Imperatae, Folium Pyrrosiae, Herba Polygoni Avicularis etc.In addition, exist because heat often depends on wet, so, improvement and the dietetic regulation of habitat environment should be noted, unsuitable eating and drinking too much at one meal, excessive drinking, eat sweet food less.

Liver and gall diseases is the commonly encountered diseases frequently-occurring disease of serious harm human health, promotes liver cell regeneration at present and prevent hepatic necrosis without specific medicament.

Herba Lysimachiae, Chinese medicine name.For the dry herb of Ofthe Primulaceae Lysimachia christinae Hance (formal name used at school: LysimachiachristinaeHance).All there is distribution south of the River each province.Summer, Qiu Erji gather.Removing impurity, dries, and cutting is raw to be used.Have heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, effect of dampness removing jaundice eliminating, can be used for pyretic stranguria, Sha Lin, urinates puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom, liver and bile stone, the diseases such as lithangiuria.Modern study, these product are mainly containing phenolic constituent and sterol, flavonoid, aminoacid, tannin, volatile oil, choline, potassium salt etc.Also have calculus, antibacterial, antiinflammatory action, all has inhibitory action to humoral immunization, cellular immunization.

Herba Lysimachiae eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom; Liver and bile stone, lithangiuria.For pyretic stranguria, outstanding kind treatment stranguria caused by urinary stone disease, can single be dense decocts for tea-drinking clothes, or is equal to Spora Lygodii, Endothelium Corneum Gigeriae Galli and uses.For jaundice due to damp-heat, can with Herba Artemisiae Scopariae, Fructus Gardeniae with using.Modern treatment cholelithiasis compatibility Herba Artemisiae Scopariae, Radix Scutellariae, the equivalent use of the Radix Aucklandiae.For diseases such as furuncle swelling toxin, snake bite and insect sting and scalds, available fresh Herba Lysimachiae smashes juice drink-service, with slag external application local.

The effect of Herba Lysimachiae: 1, for liver and bile stone and lithangiuria, pyretic stranguria, jaundice.Herba Lysimachiae has good dampness removing jaundice eliminating and the treating stranguria effect of calculus, treating the liver cholelithiasis and jaundice, can decoct soup for tea-drinking by these product alone, or compatibility Herba Artemisiae Scopariae, Radix Curcumae, Radix Et Rhizoma Rhei etc. is to strengthen clearing liver-gallbladder and calculus effect.

2, control stranguria caused by urinary stone, pyretic stranguria also alonely to get effect or be equal to use with Spora Lygodii, Endothelium Corneum Gigeriae Galli, Folium Pyrrosiae, to strengthen the merit of clear damp-heat in lower-JIAO, Tonglin Paishi; Stranguria caused by urinary stone has proposita of suffering from a deficiency of the kidney concurrently, can apply with compatibilities such as the Herba Taxilli of the kidney invigorating, semen juglandiss.

3, for sore carbuncle, acute mastitis, erysipelas, venom and traumatic injury.Herba Lysimachiae has removing toxic substances dissipating blood stasis, the merit of reducing swelling and alleviating pain, and conventional fresh goods is taken orally or external application, can smash juice drink by alone fresh grass, or smash deposited affected part, also can be equal to strengthen antipyretic and antidote functions with wild Flos Lonicerae, Herba Taraxaci, Rohdea japonica Roth.

4, Herba Lysimachiae is used for edema, tympanites, and merit for oral administration, external application all has inducing diuresis to remove edema, for cough due to lung-heat, infantile hyperpyrexia gets its antipyretic and antidote functions.

Sub-health state is more common in damp-heat constitution especially.Symptoms: the type body characteristics of damp and hot matter people: body is partially fat or become thin; Often have performance: dirty face is glossy, have acne, often feel dry mouth with bitter taste more, eyes red red, vexed slack, heavy sensation of the body is sleepy, red urine is short, constipation due to dry stool or viscid, male have dampness of scrotum, women often to have leukorrhagia to increase more.Time sick, above-mentioned sign is increased the weight of; Picture of the tongue: the partially red idle Huang of body of the tongue is greasy; Pulse condition: common sliding number; Psychological peculiarity: irascible temperament, easy on the trigger; Adaptive capacity: can not hygrothermal environment be tolerated.Common dermatosis: acne, eczema, psoriasis, pompholyx, exudative dermatitis, seborrheic dermatitis, acne rosacea etc.

Take good care of rule: adjust body method: divide the turbid damp that disappears, let out clearly volt fire.Adjust body main points: one, a surname dredges removing dampness with heat radiation: the traditional Chinese medical science is thought " dispersing fire for treating depression of fire ", in other words pathogenic fire stasis in body, and fire be tried every possible means to send, and can add eliminating fire and detoxication, declares the composition dredging Qinghua in formula.Two, tonneau removing dampness to expel the heat-evil, according to the reason of eliminating dampness by diuresis to separate it from pathogenic heat, make damp and hot from two just excrete.Help with the Rhizoma Imperatae of tonneau, Herba Lophatheri, Semen Coicis, Semen Cassiae at soothing the liver dampness removing simultaneously, heat is let out from down.

Summary of the invention

Technical problem to be solved by this invention is, liver and gall diseases is the commonly encountered diseases frequently-occurring disease of serious harm human health, promotes liver cell regeneration at present and prevent hepatic necrosis without specific medicament.Damp and hotly contain in human body, row does not go out, and will cause courage overflow, bitter taste xerostomia, being irritable and getting angry easily.Damp-heat blocking in the body, yang-energy is held back, because this person panesthesia heavy sensation of the body is sleepy.The present invention chooses the Chinese medicine of dehumidifying of relieving inflammation or internal heat, and a surname dredges removing dampness with toxin expelling fat-reducing of dispelling the heat.And it is cumbersome to take Chinese medicine, mouthfeel is not good, unsuitable long-term taking, and effect is also not necessarily desirable.Be medicine three points of poison, Chinese medicine health care product must control dosage well, its toxicity is dropped to minimum.The present invention improves Chinese medicine extraction technology greatly, the toxic component of Chinese medicine is dropped to minimum, can make absorption of human body, greatly improves its utilization rate.

For solving the problems of the technologies described above, the invention provides a kind of removing damp-heat, the Herba Lysimachiae oral liquid of function of gallbladder promoting toxin expelling, oral liquid described in it comprises the crude drug of following parts by weight: Herba Lysimachiae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Spica Prunellae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Herba Lophatheri 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Isatidis 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Abri 10 ~ 20 parts, Radix Flemingiae Philippinensis 10 ~ 20 parts, Herba Euphrasiae Regelii 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, 10 ~ 20 parts, Seem Lablab Album, Rhizoma Atractylodis 10 ~ 20 parts.

Described removing damp-heat, the Herba Lysimachiae oral liquid of function of gallbladder promoting toxin expelling, oral liquid described in it can comprise the crude drug of following parts by weight: Herba Lysimachiae 10 ~ 30 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Spica Prunellae 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Herba Lophatheri 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Fructus Forsythiae 10 ~ 15 parts, Radix Isatidis 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Abri 10 ~ 20 parts, Radix Flemingiae Philippinensis 10 ~ 20 parts, Herba Euphrasiae Regelii 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, 10 ~ 20 parts, Seem Lablab Album, Rhizoma Atractylodis 10 ~ 20 parts.

Described removing damp-heat, the Herba Lysimachiae oral liquid of function of gallbladder promoting toxin expelling, oral liquid described in it can also comprise the crude drug of following parts by weight: Herba Lysimachiae 10 ~ 40 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Spica Prunellae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Herba Lophatheri 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Isatidis 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Herba Hedyotidis Diffusae 10 ~ 15 parts, Herba Abri 10 ~ 15 parts, Radix Flemingiae Philippinensis 10 ~ 15 parts, Herba Euphrasiae Regelii 10 ~ 15 parts, Herba Portulacae 10 ~ 15 parts, Endothelium Corneum Gigeriae Galli 10 ~ 15 parts, 10 ~ 15 parts, Seem Lablab Album, Rhizoma Atractylodis 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Herba Lysimachiae oral liquid of a kind of described removing damp-heat, function of gallbladder promoting toxin expelling, and described in it, the preparation process of oral liquid comprises:

A. the preparation of Herba Lysimachiae, extraction, as component 1;

B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, add Mel after concentrated or dextrin is in harmonious proportion, after disinfection, be prepared into oral liquid bottling.

In described step a, can be placed in gathering dry Herba Lysimachiae in lid stainless steel cask, having added 70% ethanol, quality is 0.8-1 times of coarse powder, and stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Merged by percolate and leave standstill, heating is concentrated into paste, stand for standby use, becomes component 1.

In described step b, all the other raw materials described can be steeped and account in its quality 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.

In described step c, can by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel or dextrin is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Herba Lysimachiae oral liquid of a kind of described removing damp-heat, function of gallbladder promoting toxin expelling, and preparation process can also be:

A. Herba Lysimachiae is shredded extracting in water, as component 1;

B. Herba Lysimachiae is extracted rear residue to soak together with all the other raw materials described, extract 2 times as component 2;

C. component 1, component 2 are mixed concentrated after add Mel and be in harmonious proportion and granulate, pack after ultraviolet ray sterilization bactericidal.

In described step a, can add water after the Herba Lysimachiae cutting drying of collection, then extraction pot heating extraction is put into 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, as component 1; In described step b, the Herba Lysimachiae dregs of extraction can be put into together with all the other raw materials described and account for its quality 5-10 times water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, 2 extracting solution are merged and leaves standstill, reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2.

In described step c, put into concentrating under reduced pressure tank, decompression recycling ethanol after component 1 can being mixed with component 2, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, then be in harmonious proportion Mel, bottle after ultraviolet ray sterilization bactericidal.

Herba Lysimachiae is used for edema, tympanites, and merit for oral administration, external application all has inducing diuresis to remove edema, for cough due to lung-heat, infantile hyperpyrexia gets its antipyretic and antidote functions.The present invention truly has choleretic effect in pharmacology and clinical confirmation, and choleretic effect may be to promote hepatocytes secrete bile, and bile in liver and gall is increased, and intrinsic pressurely increases, and Oddi's sphincter relaxes, and causes bile excretion to increase.Damp and hotly contain in human body, row does not go out, and will cause courage overflow, bitter taste xerostomia, being irritable and getting angry easily.Damp-heat blocking in the body, yang-energy is held back, because this person panesthesia heavy sensation of the body is sleepy.The present invention chooses the Chinese medicine of dehumidifying of relieving inflammation or internal heat, and a surname dredges removing dampness with toxin expelling fat-reducing of dispelling the heat.And it is cumbersome to take Chinese medicine, mouthfeel is not good, unsuitable long-term taking, and effect is also not necessarily desirable.The present invention reduces SGOT effect selectively, and heavy dose makes liver index reduce, and also illustrates that this medicine has good hepatic cholagogic, the effect of dehumidification slimming toxin expelling.

Detailed description of the invention

Have a class fat person, ancients are called " meat people ", and we are called the obesity of firm type, contrary with puffiness due to deficiency.Their personality is irritable, is easily moved to anger.In fact, the being irritable and getting angry easily of this kind of fat person is not born, but because has damp and hot in their body.Wet is exactly stagnant water in health, stagnant water is combined with expectorant, has just become phlegm-damp, stagnant water and thermal, just becomes damp and hot.The people in rural area knows, after wheat harvest, straw can be built into one and pile up neatly by peasant, after a burst of thunderstorm, straw has been drenched, and at this moment hands puts in wheat buttress by you, will feel the inside not only tide, not only wet but also hot, thisly damply, hottish feel to be exactly damp and hot.Damp and hotly contain in wheat buttress, the time one is long, and wheat buttress will rot, ferment, and peasant makees fertilizer with it; Damp and hotly contain in human body, row does not go out, and will cause courage overflow, bitter taste xerostomia, being irritable and getting angry easily.Damp-heat blocking in the body, yang-energy is held back, because this person panesthesia heavy sensation of the body is sleepy.Feel have like one deck oil.In addition, also often can grow some acnes, acne on the face, a lot of situation of acne is because of accumulation of damp-heat in body, and row does not go out, and finally ejecting on the face, this is also the small pox that we say at ordinary times.See that a fat person has and do not have damp and hot, also should see his appetite.People's all honey stomaches of damp-heat type, are good at eating, but can eat and do not represent that spleen and stomach function is normal, are the pathological state being in " the strong spleen of stomach is weak " on the contrary.Have damp and hot meeting to have influence on stomach in body, stomach has damp and hot, and the traditional Chinese medical science is called " gastric heat dampness ", and after stomach is heated, its function will be hyperfunction, and at this moment the appetite of people will increase, and easily will feel hungry.But stomach was received prosperous, just certainly will increase the weight of the burden of spleen transporting, the effect that spleen has " transmitting and distributing the fluids ", over-burden easily causes " retention of water-damp in the body " for spleen.So this kind of fat person is called " stomach-heat moisture resistance type obesity " again by the traditional Chinese medical science.Differentiate damp-heat type fat person, also will see tongue.The partially red tongue of damp-heat type fat person body of the tongue, yellow and greasy fur, the heat in body is more contained, and tongue fur is more yellow, just look like when cooking fire too large, meal just boils Jiao, and become the rice crust of coke yellow, if or else close fire, rice crust will burn till black.So the color of tongue fur is darker, what prove in your body is damp and hot more serious.We can also to judge whether oneself has damp and hot by observing defecation, stool too dry or too wet, is all performance damp and hot in body.If health interior-heat overweights wet, then constipation due to dry stool; Weight in wet base in heat, is then defecated viscid, oliguria with reddish urine.The people of damp-heat constitution, is afraid of that wet To Be Protected from Heat, to wet environment or temperature higher, especially damp and hot friendship steam at the beginning of autumn late summer is waited and is difficult to adapt to.Whether a fat person body in have damp and hot, also should see his eyes, retention of damp-heat in the interior if seeing, heat is burnt blood network, and at this moment two ophthalmic of people just have the red red blood streak, superficial, and doctor trained in Western medicine says that this is immune reaction.In fact, damp and hot performance is had in Here it is body.Generally speaking, red red, the stool too dry of glossy, the long pox of dirty face, yellowish fur, short-tempered, eyes or too wet be all the performance of damp-heat type fat person.Damp and hot treatment, generally will divide weight in wet base or thermogravimetric.The removing dampness of weight in wet base is main, can select LIUYI SAN, sanren decoction, Pingwei San; Thermogravimetric, based on heat clearing away, can select lianpu drink, Herba Artemisiae Scopariae Decoction, GEGEN QINLIAN TANG.Under this principle, then select corresponding medicine according to some Special Manifestations, as eczema, furuncle bleb, add Flos Chrysanthemi Indici, Herba Violae, Radix Sophorae Flavescentis, Cortex Dictamni; Arthralgia adds Ramulus Cinnamomi, Caulis Lonicerae, Ramulus Mori etc.; Even dysentery of suffering from diarrhoea adds Radix Pulsatillae Decoction, Radix Sanguisorbae, Semen Plantaginis etc.; Eczema scrotum, distending pain of the testis, leucorrhea are yellow smellyly adds Radix Gentianae, Radix Sophorae Flavescentis etc.; Hematuria can add HERBA CIRSII, Rhizoma Imperatae, Folium Pyrrosiae, Herba Polygoni Avicularis etc.In addition, exist because heat often depends on wet, so, improvement and the dietetic regulation of habitat environment should be noted, unsuitable eating and drinking too much at one meal, excessive drinking, eat sweet food less.

The pharmacological action of Herba Lysimachiae

1, calculus effect:

Herba Lysimachiae has effect of cholagogic and lithagogue and diuresis and expelling stone.Show by Tinea Ranae experimental calcium oxalate renal calculus model test, it is effective that Herba Lysimachiae decocts juice for prevention and therapy Tinea Ranae experimental kidney stone.Anesthesia Canis familiaris L. semi open model recording system experimental result shows, Herba Lysimachiae can cause proximal ureteral cavity pressure to increase, and ureteral peristalsis strengthens, and urine volume increases, and has extruding and percussion, impel ureteral calculus to discharge to ureteral calculus.Calcium oxalate (CaC2O4) monohydrate is the main component of lithangiuria, polysaccharide component in the alcohol-insoluble substances of Herba Lysimachiae, inhibitory action is had to the crystalline growth of Calcium oxalate (CaC2O4) monohydrate, and inhibitory action increases with the increase of concentration, the effect of normal person's urine to the polysaccharide that the inhibitory action of Calcium oxalate (CaC2O4) monohydrate crystalline growth and 1.94 × 10 (-5) g (crude drug)/ml are extracted is suitable.Adopt conductive method, find that refined polysaccharide suppresses Calcium oxalate (CaC2O4) monohydrate crystalline growth percentage rate higher than decocting liquid precipitate with ethanol part.

2, antiinflammatory action:

Herba Lysimachiae 50g/kg and total flavones thereof and phenolic acid thing 3.75g/kg lumbar injection, significant inhibitory action is had to the mice vascular permeability increase that histamine causes, mouse ear inflammation caused by Oleum Tiglii is had to the inhibitory action of highly significant, the ankle swelling in rat cause albumen injection and rat granuloma swell and all have significant inhibitory action.

3, to immune system effect:

Herba Lysimachiae has inhibitory action to cellular immunization.Rosette Test: Herba Lysimachiae mouse boosting cell and sheep red blood cell (SRBC) form the percentage rate of Flos Rosae Rugosae, are starkly lower than matched group, even if after drug withdrawal 10 days still suppressed, its degree is similar to cyclophosphamide.It is more obvious that Herba Lysimachiae and cyclophosphamide share suppression.Skin graft rejection reacts: the time that Herba Lysimachiae group and the graft-rejection of cyclophosphamide group mouse skin occur, all late than matched group, and two medicines also use group more so.Herba Lysimachiae also has inhibitory action to body fluid rabbit epidemic disease.The mice of immunity, take Herba Lysimachiae group Hemolysin formation suppressed, in serum, content is about 1/2 of matched group; It is suppressed that Herba Lysimachiae group mice generation leptospira coagulates molten antibody, and in serum, titre is generally lower than matched group; Herba Lysimachiae and cyclophosphamide use, act on particularly remarkable.Herba Lysimachiae can strengthen the phagocytic function of mouse macrophage, and its phagocytic function percentage rate is the twice of matched group; Check that the visible Herba Lysimachiae group of phagocytic function of neutrophil has the cell number of phagocytic function all higher than matched group to different time after injected in mice staphylococcus, after injection 4,6,8 hours the most obvious.

4, to the effect of vascular smooth muscle and human blood platelets:

Herba Lysimachiae has relexation to vascular smooth muscle, also has certain inhibitory action to the human platelet aggregation of in vitro ADP and arachidonic acid-induction.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.There is function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating. Herba Artemisiae Scopariae has significant hepatoprotective effect, and to first, hepatitis B, icterohepatitis, has significant curative effect.There is function of gallbladder promoting, promote bile secretion, increase the effect that in bile, cholic acid and bilirubin are discharged. heart coronary flow can be increased, improve microcirculation, and have blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.

The Radix Paeoniae Alba is bitter, is slightly cold.Return Liver Channel.Attending effectiveness: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." not Lu ": clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors is suffered from abdominal pain, lumbago." property of medicine opinion ": control pathogen of the lung gas, Fu Zhong Xu pain, vim and vigour are gathered, and logical a surname's internal organs gather around gas, control evil pain deteriorated blood, and disease bone heat time main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus.

Stigma Maydis sweet in the mouth, light, property is put down.There is inducing diuresis to remove edema; Effect of liver heat removing function of gallbladder promoting.Main edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the wide intestinal therapeutic method to keep the adverse QI flowing downwards.Control married woman's breast knot, galactostasis, congestion and swelling pain, heating of being afraid of cold, headache body is stranded." south of the Five Ridges gather medicinal herbs record ": decoct soup with Carnis Sus domestica and control diabetes.Control again dribbling urination sandstone, bitter unbearably painful, decoct soup and be taken in small doses at short intervals.

Endothelium Corneum Gigeriae Galli returns spleen, stomach, small intestinal, urinary bladder channel.Invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain." the southern regions of the Yunnan Province book on Chinese herbal medicine ": alleviating distention in middle-JIAO spleen invigorating, help digestion mill stomach.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition.

Herba Euphrasiae Regelii is the herb of goatweed Herba Euphrasiae Regelii, Euphrasia Pectinata Ten Subsp Simplex (Freyn) Hong or short gland water rice grass, and formal name used at school: EuphrasiapectinataTen is annual herb plant, herb tool medical value.Bitter in the mouth; Cold nature.Return urinary bladder channel, function cures mainly: heat-clearing and toxic substances removing; Diuresis.Main calentura is thirsty; Headache; Cough due to lung-heat; Laryngopharynx swelling and pain; Pyretic stranguria; Dysuria; Aphtha; Carbuncle.

Herba Lophatheri (Classification system: Lophatherumgracile) is grass family, and root is medicinal, has refrigerant, antipyretic, diuresis and the effect of hastening parturition; Cure mainly: in the heart disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness, apoplectic aphasia in silence, pain wind syndrome of head, spasmolytic are throbbed with fear, pestilence fan is vexed, kill small worm, heat extraction delays spleen.Herbage can be done again.Function cures mainly: have clearing heat and relieving fidgetness, and effect ten of inducing diuresis for treating stranguria syndrome cures mainly calentura excessive thirst, aphtha of the mouth and tongue, gingival swelling and pain, children's's night crying due to fright in infant, cough due to lung-heat, and gastric heat is vomitted the sound of vomiting, hot urination stranguria with turbid discharge." detailed outline ": go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, and children's's pox poison, outer disease is vicious." the SHENGCAO property of medicine is standby to be wanted ": expectorant is quenched the thirst, except part of the body cavity above the diaphragm housing the heart and lungs fire, bright eyes, diuresis, controls nebulousurine, brings down a fever, loose hemorrhoid poison." book on Chinese herbal medicine is new again ": clearing away heart-fire, diuresis, relieving restlessness is quenched the thirst, and children's's pox poison, outer disease is vicious.

Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.Certainly, all explanations are all relevant with spleen with wet, so its property of medicine effect performance leeway is larger, all can use in general activating QI to eliminate phlegm side.As Li Shizhen (1518-1593 A.D.) is said: " Pericarpium Citri tangerinae hardship can be let out can be dry, pungent energy loose can and, it controls all kinds of diseases and ailments, always gets the merit of its dampness of regulating the flow of vital energy.Then mending with tonic, then rush down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then falling with falling medicine." as with the Rhizoma Atractylodis Macrocephalae with using; then having the effect of tonifying the spleen and stomach; with Radix Ginseng, Radix Glycyrrhizae with the effect then having tonifying the lung gas; with Semen Armeniacae Amarum with then there being logical effect of falling large intestine constipation due to disorder of QI, logical moisten the secret effect of large intestine blood with Semen Persicae with then having, with the Rhizoma Pinelliae with the effect then having dampness; with Poria with the effect then having damp eliminating; with Pericarpium Citri Reticulatae with the effect then having sending down the abnormal ascending QI preventing or arresting vomiting, with Rhizoma Zingiberis with can warming for resolving cold-phlegm, drink with Rhizoma Coptidis is same treat gastrointestinal disease better efficacy with heat-phlegm can be removed or directly take gastrointestinal

Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in the diseases such as treatment icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three burnt pathogenic heats, can treating the liver gallbladder burning hot on the conjunctival congestion and swelling pain of attacking, often join Herba Lysimachiae use, as Fructus Gardeniae soup " Shengji Zonglu ".

Herba Abri, Chinese medicine name.For the dry Herb of leguminous plant abrus cantoniensis Hance.Sweet, micro-hardship, cool.There is dampness removing jaundice eliminating, heat-clearing and toxic substances removing, effect of dispersing the depressed liver-QI for alleviating pain.Be usually used in damp and hot yellow cellulitis, side of body rib does not relax, and epigastric distending pain, acute mastitis swells and ache." illustrated handbook planted by middle traditional Chinese medicines ": " dispelling the wind and dampness pathogens osteodynia, traumatic injury blood stasis internal injury; And make refrigerant antipyretic.”

Seem Lablab Album, formal name used at school Lablabpurpureus (Linn.) Sweet, Tong Yong Ming Bian bean, spends in vain and is used as medicine with white seed, be conducive to dispelling of heat-damp in summer pathogen, the effect of invigorating the spleen to arrest diarrhea, and Seem Lablab Album also has the effect of significant regressing tumors simultaneously.Sweet in the mouth, slightly warm in nature.Can spleen invigorating dehumidifying.Containing protein, fat, saccharide, phosphorus, calcium, ferrum, zinc, the compositions such as vitamin B1 .B2 and nicotinic acid, pantothenic acid, stigmasterol, phospholipid, cyanogen glycoside, blood cell coagulin.Have wet for insufficiency of the spleen, fatigue and asthenia, eats loose stool less, or edema; Women's lukorrhagia due to hypofunction of the spleen; Heat-damp in summer is trouble, incoordination between the spleen and stomach, vomiting and diarrhoea.

Spica Prunellae is the dry fruit ear of labiate Spica Prunellae PrunellavulgarisL..All parts of the country are all produced, main product in Jiangsu, Zhejiang, Anhui, the ground such as Henan.Gather when summer, fruit ear was brownish red, removing impurity, dries.Raw use.Its property is pungent, bitter, cold.Return liver, gallbladder meridian.There is clearing away heat-fire, improving eyesight, effect of mass dissipating and swelling eliminating.Treatment conjunctival congestion and swelling pain, dizzy, order pearl nyctalgia of having a headache.Spica Prunellae bitter cold master enters Liver Channel, and kind removing fire from the liver is with improving eyesight.With controlling flaming up of liver-fire, conjunctival congestion and swelling pain, it is medicinal to join Folium Mori, Flos Chrysanthemi, Semen Cassiae etc.Among this product liver heat removing and eyesight improving, nourishing the liver of slightly holding concurrently, joins Radix Angelicae Sinensis, Fructus Lycii, can be used for deficiecny of liver-YIN, ophthalmalgia, to night more particularly; Also can accessory stick up, Radix Glycyrrhizae use, as loose in Spica Prunellae (" Zhang Shi doctor is logical ")

The aerial parts that Herba Eupatorii (EupatoriumfortuneiTurcz.) is feverfew Herba Eupatorii (Herba Chlorophyti), perennial herb, high 40-100cm.Have another name called Radix Crotonis Crassifolii, water perfume (or spice) (" herbal classic ").With all herbal medicine.There is the effect of antipyretic clearing away summer-heat, dispelling dampness to invigorate the stomach, preventing or arresting vomiting.Experience heat-damp in summer; Cold and heat are had a headache; Accumulate in moistening; Gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful; Disappear truly.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest." herbal classic ": main dredging water passages, kills diseases due to noxious agents produced by various parasites." not Lu ": except accumulation of phlegm in the hypochondrium in the heart." Kaibao Bencao ": to boil water with bath, treats wind." Chinese medicinal herbal ": deliver damp eliminating, and middleization is turbid.Control summer-heat headache, lossless heating, abdominal distention uncomfortable in chest, sweet greasy in mouth, halitosis.

Cortex Moutan, has another name called Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Autumn excavates root, and removing radicula, strips root bark, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has suppression Platelet; Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.Herba Hedyotidis Diffusae cry again Herba Hedyotidis Diffusae, tang Huang, thousand dozens beat, Herba Turczaninowiae Fastigiatae.For the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae HedyotisdiffusaWilld. [Oldenlandiadiffusa (Willd.) Roxb.].There is the function of heat-clearing and toxic substances removing diuresis, promoting blood circulation and stopping pain.Cure mainly the diseases such as malignant tumor, appendicitis, hepatitis, bronchitis, tonsillitis, laryngitis, urinary system infection, pelvic inflammatory disease, adnexitis; Furuncle carbuncle, venom are controlled in external.Modern Chinese medicine is clinical is used for the treatment of the kinds cancers such as gastric cancer, the esophageal carcinoma, intestinal cancer, uterus carcinoma, nasopharyngeal carcinoma.

Radix Flemingiae Philippinensis is pulse family Moghania plant Radix Flemingiae Philippinensis, is used as medicine with root.Formal name used at school: FlemingiaphilippinensisMerr.etRolfe root hyoscine, has the effects such as expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, bone and muscle strengthening, anti-inflammatory analgetic." south of the Five Ridges gather medicinal herbs record ": dispel wind and remove dampness.Control brothers' arthralgia pain, lumbar rheumatism is had a pain, and reason traumatic injury wound, can relaxing muscles and tendons and activating QI and blood in the collateral." Nanning City's medicine will ": strengthening bone and muscle, blood stasis removing amasss.Control traumatic injury, rheumatic ostalgia, extremity are aching and limp unable, jaundice.

Herba Portulacae (Classification system: PortulacaoleraceaL.) is Portulacaceae annual herb plant.This kind is medicine food dual purpose plant.Herb hyoscine, has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory, quenches the thirst, diuresis; Seed improving eyesight.Modern study, Herba Portulacae is also containing abundant SL3 fatty acid and vitamin A sample material.SL3 fatty acid forms cell membrane, especially brain cell membrane and the necessary material of eye cell membrane; Vitamin A sample substance maintains epithelial tissue as skin, cornea and conjunctival normal function, participates in the synthesis of rhodopsin, strengthens retinal photoreceptor performance, also participates in many oxidizing processs in body.

Rhizoma Atractylodis acrid in the mouth; Bitter; Warm in nature.It is pungent strong that amplification on Canon of Materia Medica records abnormal smells from the patient; " pearl sac " is recorded sweet pungent; " brilliant converge with essence will " records bitter but sweet flavor, warm in nature, nontoxic.Cure mainly drying damp and strengthening spleen; Wind-damp dispelling; Improving eyesight.Main the spleen and stomach being stranded by dampness; Asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention; Damp-edema; Exterior syndrome folder is wet; Head heavy sensation of the body pain; Arthromyodynia warm nature; Podomere is ached and is weighed; Flaccidity folds in a garment; Nyctalopia.Liu Wansu: improving eyesight, warming the kidney." pearl sac ": stomach invigorating can pacify spleen, non-this of all damp-edema can not remove.Li Gao: dehumidifying diaphoresis, stomach invigorating peace spleen, controls flaccidity key medicine.6. " detailed outline ": control damp-phlegm prolonged fluid-retention, or hold blood stasis under the arm and become nest capsule, and spleen wets dirty, turbid drop leukorrhagia, slidingly rush down hemorrhoidal hamorrhage.

Herba Taxilli hardship is sweet, flat.Enter liver, kidney channel.Function cures mainly invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, and the meridian dredging, beneficial blood, antiabortive.Control soreness of waist and knee joint, muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Control chronic cough, protrusion of the tongue is dizzy." herbal classic ": main lumbago, children's's stiffback, carbuncle, antiabortive, fill skin, hard, tooth, long man." not Lu ": main incised wound, goes numbness, woman's metrorrhagia, and internal injury is not enough, disease more than puerperal, lower milk.

The specific embodiment of the invention

Specific embodiment 1:

Results Herba Lysimachiae, dry, steeped in the ethanol of 5-10 times amount after chopping, be equipped with by medicated powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, and stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and is settled into component 1.

By all the other crude drug Herba Artemisiae Scopariaes, Poria, Spica Prunellae, Fructus Gardeniae, Herba Taraxaci, Herba Lophatheri, Stigma Maydis, Herba Taxilli, Herba Eupatorii, Fructus Forsythiae, Radix Isatidis, Pericarpium Citri Reticulatae, Cortex Moutan, Herba Hedyotidis Diffusae, Herba Abri, Radix Flemingiae Philippinensis, Herba Euphrasiae Regelii, Herba Portulacae, Endothelium Corneum Gigeriae Galli, Seem Lablab Album, Rhizoma Atractylodis, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.06 extractum, become component 2.

By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 2:

Results Herba Lysimachiae, dry, steeped in the ethanol of 5-10 times amount after about 5000g chopping, be equipped with by medicated powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, and stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and is settled into component 1.

By Herba Artemisiae Scopariae 1500g, Poria 1500g, Spica Prunellae 1500g, Fructus Gardeniae 1500g, Herba Taraxaci 1500g, Herba Lophatheri 1500g, Stigma Maydis 1500g, Herba Taxilli 1500g, Herba Eupatorii 1500g, Fructus Forsythiae 1500g, Radix Isatidis 1500g, Pericarpium Citri Reticulatae 1500g, Cortex Moutan 1500g, Herba Hedyotidis Diffusae 1500g, Herba Abri 1500g, Radix Flemingiae Philippinensis 1500g, Herba Euphrasiae Regelii 1500g, Herba Portulacae 1500g, Endothelium Corneum Gigeriae Galli 1500g, Seem Lablab Album 1500g, Rhizoma Atractylodis 1500g, the medicine of all the other crude drug is put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 2.

By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.35, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 3:

By dry for the Herba Lysimachiae cutting gathered, about 3500g, add water, then put into extraction pot heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, as component 1, in described step b, by the Herba Lysimachiae dregs of extraction and all the other raw material Herba Artemisiae Scopariae 1100g described, Poria 1100g, Spica Prunellae 1200g, Fructus Gardeniae 1100g, Herba Taraxaci 1100g, Herba Lophatheri 1100g, Stigma Maydis 1100g, Herba Taxilli 1100g, Herba Eupatorii 1100g, Fructus Forsythiae 1100g, Radix Isatidis 1200g, Pericarpium Citri Reticulatae 1100g, Cortex Moutan 1100g, Herba Hedyotidis Diffusae 1100g, Herba Abri 1100g, Radix Flemingiae Philippinensis 1100g, Herba Euphrasiae Regelii 1100g, Herba Portulacae 1100g, Endothelium Corneum Gigeriae Galli 1100g, Seem Lablab Album 1100g, Rhizoma Atractylodis 1000g, put into together and account for its quality 5-10 times water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, 2 extracting solution are merged and leaves standstill, reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2, put into concentrating under reduced pressure tank, decompression recycling ethanol after component 1 being mixed with component 2, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06, above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, then be in harmonious proportion Mel, bottle after ultraviolet ray sterilization bactericidal.

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: oral liquid of the present invention (preparing by implementation method 2).

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve suppository, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Suppository adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test report of the present invention

1, experiment purpose: detect the present invention to the stimulation/corrosiveness of laboratory animal skin and intensity

2, materials and methods:

2.1. tested material: oral liquid of the present invention (obtaining by embodiment method 2)

2.2. laboratory animal: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;

2.3. test method:

Its spinal column both sides, back are cut by hair in test by the healthy rabbits selecting skin intact 10 for first 24 hours, the left and right each about 4cm × 4cm of unhairing area.Get tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close after 4 hours, dismantle, and go residual tested material with warm water cleaning, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and mark.

3, experimental result: any erythema does not appear in laboratory animal skin, red and swollen, inflammation phenomenon.

4, brief summary: judge according to skin wound repair standards of grading in " disinfection technology standard " (1999), the present invention belongs to nonirritant to animal skin stimulus intensity.

Embodiment 3: long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean depilatory, observe and often organize Cavia porcellus after 24 hours and be coated with oral liquid solution 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine oral liquid long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.

Result of the test shows: oral liquid experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.

Pharmacological experiment:

Herba Lysimachiae has obvious protective effect to the hepatic injury that normal mouse is caused by carbon tetrachloride, shows as SGOT and significantly reduces, and makes liver body than reducing (heavy dose).Have significant choleretic effect to normal rat, bile flow increases and continues 2h.Ursodesoxycholic acid flow increases and continues 1 hour.Compare between group before bile cholesterol, bilirubin administration and after administration and have no the significance difference opposite sex.We conducted experimentation for this reason.

1, materials and methods

Medicine: the present invention proposes the preparation of alcohol deposit fluid: get a certain amount of crude drug of the present invention, decocting twice, adds 95 alcohol settling impurity after water-bath being concentrated into certain volume, cross liquid, filtrate recycling ethanol.Be made into 100% concentration.

Matched group is White Cloud Mountain XIAOYAN LIDAN PIAN, the accurate word Z44022243 of traditional Chinese medicines.Ursodesoxycholic acid is that Mitsubishi changes into production.

Animal ICR mice, SD rat provides by zooscopy room, the court.

The protective effect of the mouse liver injury that the 1.1 pairs of carbon tetrachloride cause: male mice 78, body weight 18-23g, is divided into six groups by body weight random stratified, often organizes 13.The present invention 3 dosage group 2.5g/kg, 5.0g/kg, 10.0g/kg, positive control drug White Cloud Mountain XIAOYAN LIDAN PIAN 10g/kg, model group, water matched group gastric infusion every day once, continuous 6d, after administration in the 6th day, 1h dewaters, and all the other respectively organize carbon tetrachloride vegetable oil 5ml/kg of equal subcutaneous injection 0.15 to matched group outward.Pluck eyeball after 16h and get kit measurement serum SGPT, SGOT of producing blood Beijing Chemical Plant.Solution cuts liver and weighs, and calculates the liver body ratio of every mice, data represent with average scholar standard deviation, carry out t inspection between group according to body weight when putting to death.

1.2 affect 1.2.1 to normal rat bile flow

The mensuration of bile flow: get rat 60, male, body weight 250 ~ 350g, weighs and is divided into five groups at random, often organizes 12, and fasting 12h before experiment, can't help water.Experiment is with 10% urethane 1.0g/kg intraperitoneal injection of anesthesia, face upward position and be fixed on operating-table, along abdomen median line open abdomen, find out duodenum, the gallbladder pipe finding white flexible in portion's mesentery is falling, two rhizoid lines are worn under it, ligation pars papillaris, " V " shape otch is made to liver direction, insert plastic conduit, ligation is fixed, namely pistac gallbladder antiperspirant is had to flow out as seen, gallbladder juice collected by test tube, postoperative with saline gauze covering abdominal cavity, after stable 1h, first collect the gallbladder juice of 30min, as the basic value before administration, then to divide into groups administration (through duodenum).The present invention 3 dosage group 2.5g/kg, 5.0g/kg, 10.0g/kg, water matched group, positive drug ursodesoxycholic acid 0.5g/kg.Measurement 1 bile is collected every 30min after administration.4h altogether.

1.2.2 the mensuration of bile component: before administration, the bile that after administration, 4h collects measures bilirubin (health Bioisystech Co., Ltd of Erie produces, caffeine method).The test kit that Determination of Cholesterol Content is produced with Eastern Europe bio-engineering corporation, enzymatic assays.

2 experimental results

The protective effect of the mouse liver injury that the 2.1 pairs of carbon tetrachloride cause: SGPT, SGOT that carbon tetrachloride causes significantly raise P < 0.01, illustrates moulding success.The present invention makes SGOT significantly reduce by three equal P < of dosage group O.05, and the present invention has no significant effect SGPT.White Cloud Mountain XIAOYAN LIDAN PIAN makes SGPT, SGOT significantly reduce (P-~ O.05).Herba Lycopi 10g/kg group makes liver body than significantly lower than carbon tetrachloride model group.Refer to table 1.

Table 1 the present invention is on the impact (X ± S) of carbon tetrachloride poisoning mice serum transaminase

Note: carry out t inspection between group, with carbon tetrachloride group than * P < 0.05, * * P < 0.01

2.2 impacts on normal rat bile flow: 2.5g/kg group of the present invention makes normal rat bile flow increase, continue 2h, increase the most remarkable < 0.05 with the 30min after administration).The each phase of 5.0g/kg group administration 2h all significantly to increase after the administration of < 0.05.10.0g/kg group all remarkable than the matched group rising (P < 0.01, P < 0.05) of each phase in 90min.Positive drug ursodesoxycholic acid also makes flow increase, and continues 1h.P < 0.05 refers to table 2.

Table 2 the present invention is on the impact (X ± S) of anesthetized rat bile flow

Note t with flow before administration for 100%, group is asked and is carried out t inspection, determine bile mesobilirubin with matched group than tiny stream before * P < 0.05, * * P < 0.01. administration of the present invention, after administration and have no significant difference with alcohol content with gallbladder compared with matched group.Refer to table 3.

Table 3 the present invention is on cholesterol, the impact of bilirubin output (X ± S) in rat bile

Discuss:

Traditional medicine think the inflammation of liver and gall system, calculus mainly toxic dampness and heat broadcast in body and cause. the liver that someone analyzes 100 routine hepatitis patients is worn pathological examination and show that acute Jaundice Jaundice 100% belongs to the damp and hot conclusion of the traditional Chinese medical science in conjunction with Syndrome Differentiation of Traditional Chinese Medicine, under so clear away the dampness and heat, evil poison purging FU-organs rushes down, eliminating damp, detoxifying is the normal rule for the treatment of.

Herba Lysimachiae is a kind of frequently seen plants, and is a kind of Chinese crude drug, and his primary efficacy can prevent calculus and cholagogic and lithagogue to say exactly has very good treatment and preventive effect to calculus, sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling, eliminating damp-heat, Sha Lin, urinate and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, cures mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.Herb is containing flavones ingredient: Quercetin (quercetin), Isoquercitrin and Quercetin-3-O-glycoside (isoquercitrin, quercetin-3-O-gluco-side), kaempferol (kaempferol), trifolin and kaempferol-3-O-galactoside (trifolin, kaempferol-3-O-galactosids), 3, 2 ', 4 ', 6`, tetrahydroxy-4, 3`-dimethoxy chalcone (3, 2 ', 4 ', 6`, tetrahydroxy-4, 3 '-dimethoxychal-cone), kaempferol-3-O-Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) three glucoside (kaempferol-3-O-lysi-machiatrioside), kaempferol-3-O-Portugal rhamnocitrin-3, 4-glucosulfone (rhamnocitrin-3, 4-diglucOside), mountain parent's phenol-3-O-rutinoside (kaempferol-3-O-rutinoside), kaempferol-3-O-rhamnoside-7-O-rhamanopyranosyl (1 → 3)-rhamnoside [kaempferol-3-O-rhamnoside-7-O-rhamnosyl (1 → 3)-rhamnosi-de].Also containing p-hydroxy Benzoic Acid (p-hydroxybenzoicacid), uracil (uridine), sodium chloride; Potassium chloride, nitrite, cyclic adenosine monophosphate (cAMP), cyclic guanylic acid (cGMP) sample material, 9 kinds of elements such as polysaccharide and calcium, magnesium, ferrum, zinc, copper, manganese, cadmium, nickel, cobalt, calcium, magnesium, iron content are at most for liver and bile stone and lithangiuria, pyretic stranguria, jaundice.

Herba Lysimachiae has good dampness removing jaundice eliminating and the treating stranguria effect of calculus, treating the liver cholelithiasis and jaundice, can decoct soup for tea-drinking by these product alone, or compatibility Herba Artemisiae Scopariae, Radix Curcumae, Radix Et Rhizoma Rhei etc. is to strengthen clearing liver-gallbladder and calculus effect.

Clinical trial

From year June in March, 2012 to 2015, adopt from intending liver heat removing dampness removing Jiangzhitang treatment fatty liver 70 example, obtain significant curative effect, the out-patient for health check-up finder and unit of going together in 60 examples originally organized by clinical data, 35 ~ 50 years old age, average 44 years old; 1 ~ 6 year course for the treatment of is not etc.Two groups of data are checked through Ridit, and the aspect such as age, the course of disease is all without the significance difference opposite sex.There is comparability.Diagnosis basis clinical manifestation and iconography and lab testing, all meet fatty liver feature.Treatment group and each 30 examples of matched group are divided at random by medical order.Diagnostic criteria: State Administration of Traditional Chinese Medicine Liver of TCM sick Pivot Subjects writing group chief editor " traditional Chinese medical science hepatopathy conventional treatment " October in 2005 the 1st edition.

Therapeutic Method

Treatment group: oral liquid of the present invention, square medicine composition Herba Lysimachiae 30g, Herba Artemisiae Scopariae 12g, Poria 12g, Spica Prunellae 11g, Fructus Gardeniae 11g, Herba Taraxaci 12g, Herba Lophatheri 12g, Stigma Maydis 13g, Herba Taxilli 12g, Herba Eupatorii 13g, Fructus Forsythiae 12g, Radix Isatidis 12g, Pericarpium Citri Reticulatae 12g, Cortex Moutan 12g, Herba Hedyotidis Diffusae 12g, Herba Abri 11g, Radix Flemingiae Philippinensis 12g, Herba Euphrasiae Regelii 11g, Herba Portulacae 12g, Endothelium Corneum Gigeriae Galli 12g, Seem Lablab Album 11g, Rhizoma Atractylodis 11g.Prepare by embodiment method 2, every day 3 bottles, after serveing on 2 months, withdraw 1 week, then to take 1 month be 1 course for the treatment of.

Matched group: liver-strengthening capsule (Shijiazhuang Dongfang Pharmaceutical Co., Ltd.'s production) the accurate word of traditional Chinese medicines: ZL0980012,1 time 5, ld3 time.Two months 1 courses for the treatment of.Treatments period withdraws any medicine.

Criterion of therapeutical effect: clinical cure: symptom, sign disappear completely, liver function is normal, and blood fat is normal, and B ultrasonic prompting liver acoustic image recovers normal.Effective: symptom and sign disappears, glutamate pyruvate transaminase and blood fat raised portion decline more than 50%, and B ultrasonic prompting fatty liver ultrasonogram alleviates.Invalid: not reach above standard person.

Therapeutic outcome is in table 1.

The comparitive study of table 1 treatment group and matched group

Group	Number of cases	Recovery from illness	Effectively	Invalid	Total effective rate *
						Treatment group	35	11	16	8	77.14％
Matched group	35	9	11	15	57.14％

* clinical cure be effectively considered as effective number of cases, comparing through statistical procedures two groups has notable difference (P < 0.05), and treatment group is obviously better than matched group.

Discuss: fatty liver is the adipose metabolism disorder disease just causing medical circle to pay much attention in recent years.Modern medicine think primary disease primarily of lipid take the photograph people too much, fat or poisonous substance (ethanol), or heredity and metabolic factor to cause excessive fat to pile up in liver pathogenic.Consult allusion, though motherland's medical science does not have the name of disease of fatty liver, in successive dynasties doctor nationality, have the record of some similar primary disease." Ling Shu Miraculous Pivot or Divine Axis. disorder of defensive QI " namely point out in human body, there is " fat, " and have " cream " to have "flesh" (nonproductive construction) and be divided into " fat people ", " cream people, " " meat people " according to the difference of human body body.Its cloud: " cream person, many gas and skin are vertical slow, therefore it is vertical fertile indulge abdomen.Meat person, health holds large.Fat person, its body zooms in." Zhang Zhi's acute hearing " Ling Shu Miraculous Pivot or Divine Axis variorum " cloud: " and the gas of middle Jiao steams body fluid. and its Tianjin is micro-overflows in outer then skin and flesh cream fertilizer.Remaining in meat, then cream fat is plentiful." Zhang Jingyue Systematic Compilation of Internal Classic also cloud: " seminal fluid and combined into cream, to fill up among bone sky, then for brain is marrow, for essence is blood." as can be seen here, the cream fat of description above and the lipid material of modern medicine similar.Also illustrate that cream fat is one of physiology constituent of human body in fact, belong to the category of seminal fluid, and mutually can transform with other compositions of body fluid, Tianjin is cream from turbidity simultaneously, solidifying then be fat.Normal fat with the operation nutrition vital organs of the human body of blood, the white bones of the body of extremity and brains.If innate deficiency, eating and drinking without temperance, taste are lacked of proper care, feelings will internal injury, and liver and gall are lacked of proper care, old, the empty reason such as not enough of body, and cause hyperphagia or transmission, utilization, excretion are abnormal, all in blood, fat is piled up, too much fat turbidity.And become turbid damp, phlegm retention, invade excessive tunnel, make QI-blood circulation obstacle, the essence of blood stasis is in particular in microcirculation disturbance, the kinetics exception of blood flow and Abnormal Blood Rheology.And the turbid pathological product being both body visceral dysfunction with blood stasis of expectorant, finally form Liver Channel expectorant to coagulate the stasis of blood stagnant, the pathological change that the intrahepatic fat stasis of blood is long-pending, and occur the card such as " phlegm syndrome ", " blood stasis syndrome ", " BI-syndrome involved the blood vessels ".

Comprehensively it seems that the category such as surely belong to liver painful abdominal mass, hypochondriac pain, lump in the abdomen, gather is based on above-mentioned cognition, follow soothing the liver and blood fat reducing, dampness removing and doublely to reduce phlegm, invigorate blood circulation and the rule for the treatment of of blood stasis dispelling, adopt the Chinese medicine of soothing the liver blood fat reducing, dispelling phlegm and eliminating dampness, blood circulation promoting and dispersing pathogen accumulation, softening the hard mass removing food stagnancy.

Claims (10)

1. a removing damp-heat, the Herba Lysimachiae oral liquid of function of gallbladder promoting toxin expelling, it is characterized in that, described oral liquid comprises the crude drug of following parts by weight: Herba Lysimachiae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Spica Prunellae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Herba Lophatheri 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Isatidis 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Abri 10 ~ 20 parts, Radix Flemingiae Philippinensis 10 ~ 20 parts, Herba Euphrasiae Regelii 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, 10 ~ 20 parts, Seem Lablab Album, Rhizoma Atractylodis 10 ~ 20 parts.

2. removing damp-heat according to claim 1, the Herba Lysimachiae oral liquid of function of gallbladder promoting toxin expelling, it is characterized in that, described oral liquid comprises the crude drug of following parts by weight: Herba Lysimachiae 10 ~ 30 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Spica Prunellae 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Herba Lophatheri 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Fructus Forsythiae 10 ~ 15 parts, Radix Isatidis 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Abri 10 ~ 20 parts, Radix Flemingiae Philippinensis 10 ~ 20 parts, Herba Euphrasiae Regelii 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, 10 ~ 20 parts, Seem Lablab Album, Rhizoma Atractylodis 10 ~ 20 parts.

3. removing damp-heat according to claim 1, the Herba Lysimachiae oral liquid of function of gallbladder promoting toxin expelling, it is characterized in that, described oral liquid comprises the crude drug of following parts by weight: Herba Lysimachiae 10 ~ 40 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Spica Prunellae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Herba Lophatheri 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Isatidis 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Herba Hedyotidis Diffusae 10 ~ 15 parts, Herba Abri 10 ~ 15 parts, Radix Flemingiae Philippinensis 10 ~ 15 parts, Herba Euphrasiae Regelii 10 ~ 15 parts, Herba Portulacae 10 ~ 15 parts, Endothelium Corneum Gigeriae Galli 10 ~ 15 parts, 10 ~ 15 parts, Seem Lablab Album, Rhizoma Atractylodis 10 ~ 15 parts.

4. the preparation method of the Herba Lysimachiae oral liquid of removing damp-heat, function of gallbladder promoting toxin expelling according to any one of claims 1 to 3, it is characterized in that, the preparation process of described oral liquid comprises:

A. the preparation of Herba Lysimachiae, extraction, as component 1;

B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, add Mel after concentrated or dextrin is in harmonious proportion, after disinfection, be prepared into oral liquid bottling.

5. the preparation method of the Herba Lysimachiae oral liquid of removing damp-heat, function of gallbladder promoting toxin expelling according to claim 4, it is characterized in that, in described step a, be placed in lid stainless steel cask by gathering dry Herba Lysimachiae, add 70% ethanol, quality is 0.8-1 times of coarse powder, stirs, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Merged by percolate and leave standstill, heating is concentrated into paste, stand for standby use, becomes component 1.

6. the preparation method of the Herba Lysimachiae oral liquid of removing damp-heat, function of gallbladder promoting toxin expelling according to claim 4, is characterized in that, in described step b, all the other raw materials described are steeped and accounts in its quality 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.

7. the preparation method of the Herba Lysimachiae oral liquid of removing damp-heat function of gallbladder promoting toxin expelling according to claim 4, it is characterized in that, in described step c, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel or dextrin is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

8. the preparation method of the Herba Lysimachiae oral liquid of removing damp-heat, function of gallbladder promoting toxin expelling according to any one of claims 1 to 3, it is characterized in that, preparation process can also be:

A. Herba Lysimachiae is shredded extracting in water, as component 1;

B. Herba Lysimachiae is extracted rear residue to soak together with all the other raw materials described, extract 2 times as component 2;

C. component 1, component 2 are mixed concentrated after add Mel and be in harmonious proportion and granulate, pack after ultraviolet ray sterilization bactericidal.

9. the preparation method of the Herba Lysimachiae oral liquid of removing damp-heat, function of gallbladder promoting toxin expelling according to claim 8, it is characterized in that, in described step a, add water after the Herba Lysimachiae cutting drying of collection, then extraction pot heating extraction is put into 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, as component 1; In described step b, the Herba Lysimachiae dregs of extraction are put into together with all the other raw materials described and accounts for its quality 5-10 times water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, 2 extracting solution are merged and leaves standstill, reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2.

10. the preparation method of the Herba Lysimachiae oral liquid of removing damp-heat, function of gallbladder promoting toxin expelling according to claim 8, it is characterized in that, in described step c, concentrating under reduced pressure tank is put into after component 1 being mixed with component 2, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, then be in harmonious proportion Mel, bottle after ultraviolet ray sterilization bactericidal.