CN101085251A - Traditional Chinese medicine preparation for treating nephrotic syndrome - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating nephrotic syndrome which is prepared from more than ten kinds of Chinese medicinal herbs including prepared rehmannia root, broomrape, morinda root and poria peel.

Description

A kind of Chinese medicine preparation of treatment nephrotic syndrome

Technical field

The present invention relates to treat a kind of Chinese medicine preparation of nephrotic syndrome, is that a kind of nephrotic syndrome for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

(Nephrotic Syndrome NS) is proposed in 1932 by foreign scholar Hriction nephrotic syndrome.In order to summarize one group of card Hou Qun in the renal glomerular disease, it accounts for 70%～90% in child's renal glomerular disease, also account for 20%～30% in the adult.All have clinically a large amount of albuminuria (every day＞3.5g), hypoproteinemia (albumin＜30g/L), obviously edema, hyperlipemia (characteristic person such as serum cholesterol＞6.5mmol/L) can examine and is nephrotic syndrome.Nephrotic syndrome is at the clinical branch that constitutional and Secondary cases are arranged.Primary nephrotic syndrome (PNS) refers to by the sick causer of primary glomerular, adult's the most nephrotic syndrome of 2/3 and child is constitutional, pathological change is mainly the minute lesion type, and part is changes such as film, proliferative, film proliferative and focal nephrosclerosis.The patient of morbidity more than 45 years old, may be except must noting with malignant tumor, with Hodgkin, membranous nephropathy accompanies by solid tumors such as lung, breast, gastrointestinal etc. as minimal change nephropathy.The Secondary cases nephrotic syndrome is meant and is secondary to the whole body other diseases or by specificity cause of disease causer, as medicine mediation property nephrotic syndrome, the nephrotic syndrome that causes by allergy, poisoning, immunoreation, the nephrotic syndrome that causes by infection such as antibacterial, virus, parasites, nephrotic syndrome due to tumor and the heredity, nephrotic syndrome that metabolic disease caused such as systemic disease such as connective tissue, anaphylactoid purpura and diabetes, amyloidosis etc.Nephrotic syndrome 1/3 and the child 10% who is grown up can be by above-mentioned cause of disease secondary.Disease categories such as " edema " of nephrotic syndrome ownership Chinese medicine, " asthenia ".The clinical manifestation of primary disease is: a large amount of albuminuria (＞3.5g/24h), hypoproteinemia (albumin＜30g/L), obviously edema, hyperlipemia.The nephrotic syndrome course of disease is long, the relapse rate height, and simple western medicine treatment often can not obtain ideal effect, some intractable nephrotic syndromes especially, clinical treatment is often more thorny.And adopt the comprehensive method treatment nephrotic syndrome of Chinese and western medicine, and not only enlarged the treatment approach, and clinical confirmation obtained gratifying curative effect, be considered to comparatively ideal therapeutic scheme.

The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as retention of damp-heat in the interior, the wet dipping of water, edema due to YANG-insufficiency, stagnation of dampness due to deficiency of the spleen, edema due to wind pathogen Xiang Bo clinically, obtains very good effect.Therefore invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of nephrotic syndrome.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Fructus Ligustri Lucidi of 1.5～6 parts of Radix Morindae Officinaliss of Radix Rehmanniae Preparata

0.1～2 part of 1.0～4 parts of Fructus Corni of 1.5～6 parts of Cortex Sclerotii Poriae of Rhizoma Atractylodis Macrocephalae (parched)

0.1～2 part of 1.0～4 parts of Rhizoma Chuanxiong of 1.5～6 parts of Herba Leonuris of Rhizoma Imperatae

0.1～2 part of 1.0～4 portions of Semen Plantaginis of 1.0～4 portions of Rhizoma Dioscoreaes of Herba Cistanches.

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 1.5～2.5 parts of Fructus Ligustri Lucidi of 2.5～3.5 parts of Radix Morindae Officinaliss of Radix Rehmanniae Preparata

0.5～1.5 part of 1.5～2.5 parts of Fructus Corni of 2.5～3.5 parts of Cortex Sclerotii Poriae of Rhizoma Atractylodis Macrocephalae (parched)

0.5～1.5 part of 1.5～2.5 parts of Rhizoma Chuanxiong of 2.5～3.5 parts of Herba Leonuris of Rhizoma Imperatae

0.5～1.5 part of 1.5～2.5 portions of Semen Plantaginis of 1.5～2.5 portions of Rhizoma Dioscoreaes of Herba Cistanches.

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 2 parts of Fructus Ligustri Lucidi of 3 parts of Radix Morindae Officinaliss of Radix Rehmanniae Preparata

1 part of 2 parts of Fructus Corni of 3 parts of Cortex Sclerotii Poriae of Rhizoma Atractylodis Macrocephalae (parched)

1 part of 2 parts of Rhizoma Chuanxiong of 3 parts of Herba Leonuris of Rhizoma Imperatae

1 part of 2 portions of Semen Plantaginis of 2 portions of Rhizoma Dioscoreaes of Herba Cistanches.

Drug action mechanism among the present invention is as follows:

The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair, anemia etc.(the 197th page of chief editor such as the firm Xiao Ying of party " Chinese medicine and health food development and exploitation " People's Health Publisher).

Rhizoma Atractylodis Macrocephalae (parched) hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Imperatae property of medicine is sweet, and is cold.GUIXIN, lung, stomach, urinary bladder channel.Has clearing away heat and promoting production of body fluid, cooling blood for hemostasis, the effect of inducing diuresis for treating stranguria syndrome.Can treat the calentura excessive thirst, dyspnea and cough due to lung-heat, the gastric heat vomiting, heat in blood is hemorrhage, the puckery pain of dribbling urination, edema, jaundice etc.(the 992nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Herba Cistanches property of medicine is sweet, salty, temperature.Return kidney, large intestine channel.Has kidney-replenishing, benefiting essence-blood, the effect in intestine moistening road.Can treat the sexual impotence of kidney yang deficiency, asthenia of essence and blood, seminal emission, nebulousurine, the frequent micturition heeltap, the lumbago flaccidity of the lower limbs, tinnitus order flower, menstruation is spread out the phase, infertility, dryness of the intestine constipation etc.(the 1226th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Morindae Officinalis property of medicine suffering, sweet, tepor.Return liver, kidney channel.Has reinforcing the kidney and supporting YANG, bone and muscle strengthening, the effect of expelling wind and removing dampness.Can treat impotence due to deficiency of the kidney, the seminal emission premature ejaculation, few abdomen cold type of pain, incontinence of urine, cold womb is infertile, anemofrigid-damp arthralgia, soreness of the waist and knees, rheumatism beriberi etc.(the 709th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Sclerotii Poriae is flat, and sweet in the mouth, light is nontoxic.Effect with inducing diuresis to remove edema.It is full to treat the water damp-edema, dysuria etc.(the 2156th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Herba Leonuri property of medicine suffering, hardship are slightly cold.Return liver, kidney, pericardium channel.Has promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing.Can treat menoxenia, amenorrhea, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, traumatic injury, dysuria, edema, carbuncle skin infection etc.(the 2697th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Dioscoreae property of medicine is sweet, flat.Return spleen, lung, kidney channel.Have spleen reinforcing, support lung, reinforce the kidney, the effect that benefit is smart.Can treat diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency is quenched one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.Carbuncle is controlled in external, scrofula etc.(the 218th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Fructus Ligustri Lucidi property of medicine is sweet, bitter, cold.Return liver, kidney channel.Has liver and kidney tonifying, clearind deficient heat, the effect that makes eye bright.Can treat Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision etc.(the 324th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The acid of the Fructus Corni property of medicine, tepor.Return liver, kidney channel.Has liver and kidney tonifying, the effect that convergence is taken off admittedly.Can treat and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding etc.(the 248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Chuanxiong property of medicine suffering, temperature.Return liver, gallbladder, pericardium channel.Has blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, the effect of wind-expelling pain-stopping.Can treat menoxenia, the amenorrhea dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal ， mass in the abdomen lump, pain in chest and hypochondrium, it is dizzy to have a headache, anemofrigid-damp arthralgia, traumatic injury, ulcer sores etc.(the 292nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Semen Plantaginis property of medicine is sweet, light, is slightly cold.Return lung, liver, kidney, urinary bladder channel.Have heat clearing away, diuresis makes eye bright, the expectorant effect.Can treat urinary obstruction, stranguria with turbid discharge, leukorrhagia, edema, the heat-damp in summer dysentery, conjunctival congestion is hidden from view, and the expectorant heat syndrome cough is breathed heavily etc.(the 539th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Rehmanniae Preparata, Rhizoma Atractylodis Macrocephalae (parched) and Rhizoma Imperatae; With Fructus Corni, Herba Cistanches, Radix Morindae Officinalis, Cortex Sclerotii Poriae, Herba Leonuri, Rhizoma Dioscoreae and Fructus Ligustri Lucidi is ministerial drug; With Rhizoma Chuanxiong and Semen Plantaginis is adjuvant.All medicines are harmonious, and are total to the tool nourishing the liver and kidney, the effect of yin nourishing row water.The treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment nephrotic syndrome of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat nephrotic syndrome, and the prevention of nephrotic syndrome is also had good effect, and the treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing medicine of the present invention, as follows through clinical test results to treatment management of Idiopathic Nephrotic Syndrome in Children effect; Treatment nephrotic syndrome patient 17 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.9 examples of fully recovering account for 52.94%, and 5 examples that take a turn for the better account for 29.41%, and invalid 3 examples account for 17.65%, and total effective rate reaches 82.35%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

2 parts of 2 parts of Fructus Ligustri Lucidi of 3 parts of Radix Morindae Officinaliss of Radix Rehmanniae Preparata

1 part of 2 parts of Fructus Corni of 3 parts of Cortex Sclerotii Poriae of Rhizoma Atractylodis Macrocephalae (parched)

1 part of 2 parts of Rhizoma Chuanxiong of 3 parts of Herba Leonuris of Rhizoma Imperatae

1 part of 2 portions of Semen Plantaginis of 2 portions of Rhizoma Dioscoreaes of Herba Cistanches.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment nephrotic syndrome that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation of treatment nephrotic syndrome is characterized in that it is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Fructus Ligustri Lucidi of 1.5～6 parts of Radix Morindae Officinaliss of Radix Rehmanniae Preparata

0.1～2 part of 1.0～4 parts of Fructus Corni of 1.5～6 parts of Cortex Sclerotii Poriae of Rhizoma Atractylodis Macrocephalae (parched)

0.1～2 part of 1.0～4 parts of Rhizoma Chuanxiong of 1.5～6 parts of Herba Leonuris of Rhizoma Imperatae

0.1～2 part of 1.0～4 portions of Semen Plantaginis of 1.0～4 portions of Rhizoma Dioscoreaes of Herba Cistanches.

2, a kind of Chinese medicine preparation of treatment nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:

1.5～2.5 parts of 1.5～2.5 parts of Fructus Ligustri Lucidi of 2.5～3.5 parts of Radix Morindae Officinaliss of Radix Rehmanniae Preparata

0.5～1.5 part of 1.5～2.5 parts of Fructus Corni of 2.5～3.5 parts of Cortex Sclerotii Poriae of Rhizoma Atractylodis Macrocephalae (parched)

0.5～1.5 part of 1.5～2.5 parts of Rhizoma Chuanxiong of 2.5～3.5 parts of Herba Leonuris of Rhizoma Imperatae

0.5～1.5 part of 1.5～2.5 portions of Semen Plantaginis of 1.5～2.5 portions of Rhizoma Dioscoreaes of Herba Cistanches.

3, a kind of Chinese medicine preparation of treatment nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:

2 parts of 2 parts of Fructus Ligustri Lucidi of 3 parts of Radix Morindae Officinaliss of Radix Rehmanniae Preparata

1 part of 2 parts of Fructus Corni of 3 parts of Cortex Sclerotii Poriae of Rhizoma Atractylodis Macrocephalae (parched)

1 part of 2 parts of Rhizoma Chuanxiong of 3 parts of Herba Leonuris of Rhizoma Imperatae

1 part of 2 portions of Semen Plantaginis of 2 portions of Rhizoma Dioscoreaes of Herba Cistanches.