CN101264218A - Medicaments assembly for clearing heat and removing dampness, smoothing liver and invigorating spleen and preparation thereof - Google Patents
Medicaments assembly for clearing heat and removing dampness, smoothing liver and invigorating spleen and preparation thereof Download PDFInfo
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Abstract
The invention discloses a medical composition and the preparation method for clearing away heat, removing dampness through diuresis, soothing liver and strengthening spleen. The active ingredients of the medical composition are extracted from the following medicinal materials: vinegar-baked bupleurum, oldenlandia diffusa, oriental wormwood, ash bark, isatis root, dandelion, oriental waterplantain rhizome, poria cocos, siebold stonecrop, weeping forsythia, largehead atractylodes rhizome, plantain seed, fried gardenia, fried rhizoma anemarrhenae, common cephalanoplos herb and root of herbaceous peony. The active ingredients of the medical composition has the advantages of clearing away heat, removing dampness through diuresis, soothing liver, strengthening spleen and curing chronic active hepatitis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to drug regimen of a kind of clearing away heat-damp and promoting diuresis, soothing liver and strengthening spleen and preparation method thereof.
Technical background
Viral hepatitis is caused by hepatitis virus.At present main 5 kinds on the first type, B-mode, third type, fourth type, penta type that divide caused by hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), five kinds of viruses of hepatitis E virus (HEV) respectively.In recent years find to have type hepatitis and hepatitis G again.
Hepatitis A virus is mainly discharged from intestinal, the peroral infection by the daily life contact; Hepatitis B virus can drain into external by various body fluid, as by blood, seminal fluid, vaginal secretions, saliva, milk, menstruation, tear, urine, antiperspirant etc., in fact finds HBsAg in all secretions of patient.Therefore the route of transmission of hepatitis B mainly contains three kinds: (1) mother and baby's perinatal transmission: contact female blood or Sanguis caprae seu ovis during main system childbirth and contact closely with puerperal and cause.(2) iatrogenic infection: syringe needle, acupuncture needle, blood sampling apparatus by blood transfusion, blood plasma, blood product or use Virus Pollution are propagated.(3) closely contact transmission: trafficability characteristic contact transmission or propagate by the mucocutaneous close contact that causes of breakage.Hepatitis C virus causes by blood transfusion that mainly primary disease accounts for more than 70% of post-transfusion hepatitis.Hepatitis D route of transmission and hepatitis B are basic identical, and intravenous injection drug use, commasculatio, prostitute and often use blood product or the kidney dialysis patient are the high-risk group of primary disease.Hepatitis E mainly by contaminated water source, infects through fecal oral route.Hepatitis virus is not separated successfully so far as yet, and its cause of disease is not determined as yet and generally acknowledged.At present type hepatitis had both been lacked sure generally acknowledged object, and lacked the specific diagnostic method yet, and still mainly adopted exclusive method, the approach of its propagation is also very not clear.The route of transmission of hepatitis G and hepatitis B, hepatitis C are basic identical, so Hepatitis G Virus virus can infect simultaneously with hepatitis C or second virus.
Hepatitis belong to the traditional Chinese medical science stagnation of liver-QI, hypochondriac pain, jaundice, pestilence, gather category, main clinical manifestation is fatigue and weak, inappetence, feels sick, symptoms such as distension and fullness in the abdomen, hypochondriac pain, jaundice.Viral hepatitis, it is that basis " stasis of blood stagnates " is a basic pathogenesis that the cause of disease is worked as with " poison ", with the infection is approach, and its etiology and pathogenesis is in general held back the volt taste for the heresy of epidemic disease caused by damp-heat pathogen poison, middle burnt stasis, production of fire due to stagnation of damp, cloudy liquid in the consumer, and cause the hepatic and renal YIN deficiency, so pathologic basis is liver,spleen,kidney three dirty imbalance of YIN and YANG, pathogen is stopped up knot, the damp and hot tired choke blood stasis that stagnates.
The Therapeutic Principle is based on the detoxifcation regulating qi to disperse stagnation, carry out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs in conjunction with state of an illness differentiation, and in conjunction with human body immunity improving function inhibition virus, improve the liver blood circulation, anti-hepatic fibrosis promotes hepatocyte to repair, and its Therapeutic Method is with nourishing the liver, easing the affected liver, soothing liver-QI, regulating the flow of QI to dissipate blood stasis is set upright, the clearing away heat-damp and promoting diuresis detoxifcation.
Summary of the invention
One of purpose of the present invention provides the drug regimen of a kind of clearing away heat-damp and promoting diuresis, soothing liver and strengthening spleen.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Bupleuri (processed with vinegar) 100-300 part Herba Hedyotidis Diffusae 100-300 part Herba Artemisiae Scopariae 100-300 part
Cortex Fraxini 100-300 part Radix Isatidis 60-240 part Herba Taraxaci 60-240 part
Rhizoma Alismatis 100-300 part Poria 100-300 part Herba Lysimachiae 60-240 part
Fructus Forsythiae 60-240 part Rhizoma Atractylodis Macrocephalae (parched) 60-240 part Semen Plantaginis 60-240 part
Fructus Gardeniae (parched) 60-240 part stir-baked RHIZOMA ANEMARRHENAE 60-240 part Herba Cirsii 60-240 part
Radix Paeoniae Alba 60-240 part
The active component that preferred following raw materials according is made, curative effect is better:
1150 parts of 150 portions of Herba Artemisiae Scopariaes of 150 parts of Herba Hedyotidis Diffusaes of Radix Bupleuri (processed with vinegar)
120 parts of 120 parts of Herba Taraxacis of 150 parts of Radix Isatidis of Cortex Fraxini
120 parts of 150 portions of Herba Lysimachiaes of 150 parts of Poria of Rhizoma Alismatis
120 parts of 120 portions of Semen Plantaginiss of 120 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Fructus Forsythiae
120 parts of 120 portions of Herba Cirsiis of 120 parts of stir-baked RHIZOMA ANEMARRHENAEs of Fructus Gardeniae (parched)
120 parts of the Radix Paeoniae Albas
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) getting medical materials such as Radix Bupleuri (processed with vinegar), Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae, Cortex Fraxini, Radix Isatidis, Herba Taraxaci, Rhizoma Alismatis, Poria, Herba Lysimachiae, Fructus Forsythiae, Rhizoma Atractylodis Macrocephalae (parched), Semen Plantaginis, Fructus Gardeniae (parched), stir-baked RHIZOMA ANEMARRHENAE, Herba Cirsii, the Radix Paeoniae Alba adds 8-12 times of decocting and boils 2-3 time, the 1st time 2-3 hour, the 2nd time 1.5-2 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) the gained dried cream powder is broken, sieve, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the effect of clearing away heat-damp and promoting diuresis, soothing liver and strengthening spleen.Be used for the treatment of chronic active hepatitis.
By the following examples technical scheme of the present invention is described further.
The specific embodiment
Embodiment 1: the preparation method of granule
1. write out a prescription:
1150 parts of 150 portions of Herba Artemisiae Scopariaes of 150 parts of Herba Hedyotidis Diffusaes of Radix Bupleuri (processed with vinegar)
120 parts of 120 parts of Herba Taraxacis of 150 parts of Radix Isatidis of Cortex Fraxini
120 parts of 150 portions of Herba Lysimachiaes of 150 parts of Poria of Rhizoma Alismatis
120 parts of 120 portions of Semen Plantaginiss of 120 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Fructus Forsythiae
120 parts of 120 portions of Herba Cirsiis of 120 parts of stir-baked RHIZOMA ANEMARRHENAEs of Fructus Gardeniae (parched)
120 parts of the Radix Paeoniae Albas
2. preparation technology:
(1) getting medical materials such as Radix Bupleuri (processed with vinegar), Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae, Cortex Fraxini, Radix Isatidis, Herba Taraxaci, Rhizoma Alismatis, Poria, Herba Lysimachiae, Fructus Forsythiae, Rhizoma Atractylodis Macrocephalae (parched), Semen Plantaginis, Fructus Gardeniae (parched), stir-baked RHIZOMA ANEMARRHENAE, Herba Cirsii, the Radix Paeoniae Alba adds 8 times of decoctings and boils 2 times, the 1st time 2 hours, the 2nd time 1.5 hours, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) the gained dried cream powder is broken, sieve, add cane sugar powder, mixing is made granule, drying, promptly.Embodiment 2: the preparation method of tablet
1. write out a prescription:
1150 parts of 150 portions of Herba Artemisiae Scopariaes of 150 parts of Herba Hedyotidis Diffusaes of Radix Bupleuri (processed with vinegar)
120 parts of 120 parts of Herba Taraxacis of 150 parts of Radix Isatidis of Cortex Fraxini
120 parts of 150 portions of Herba Lysimachiaes of 150 parts of Poria of Rhizoma Alismatis
120 parts of 120 portions of Semen Plantaginiss of 120 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Fructus Forsythiae
120 parts of 120 portions of Herba Cirsiis of 120 parts of stir-baked RHIZOMA ANEMARRHENAEs of Fructus Gardeniae (parched)
120 parts of the Radix Paeoniae Albas
2. preparation technology
(1) getting medical materials such as Radix Bupleuri (processed with vinegar), Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae, Cortex Fraxini, Radix Isatidis, Herba Taraxaci, Rhizoma Alismatis, Poria, Herba Lysimachiae, Fructus Forsythiae, Rhizoma Atractylodis Macrocephalae (parched), Semen Plantaginis, Fructus Gardeniae (parched), stir-baked RHIZOMA ANEMARRHENAE, Herba Cirsii, the Radix Paeoniae Alba adds 8 times of decoctings and boils 2 times, the 1st time 2 hours, the 2nd time 1.5 hours, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) the gained dried cream powder is broken, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
1150 parts of 150 portions of Herba Artemisiae Scopariaes of 150 parts of Herba Hedyotidis Diffusaes of Radix Bupleuri (processed with vinegar)
120 parts of 120 parts of Herba Taraxacis of 150 parts of Radix Isatidis of Cortex Fraxini
120 parts of 150 portions of Herba Lysimachiaes of 150 parts of Poria of Rhizoma Alismatis
120 parts of 120 portions of Semen Plantaginiss of 120 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Fructus Forsythiae
120 parts of 120 portions of Herba Cirsiis of 120 parts of stir-baked RHIZOMA ANEMARRHENAEs of Fructus Gardeniae (parched)
120 parts of the Radix Paeoniae Albas
2. preparation technology:
(1) getting medical materials such as Radix Bupleuri (processed with vinegar), Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae, Cortex Fraxini, Radix Isatidis, Herba Taraxaci, Rhizoma Alismatis, Poria, Herba Lysimachiae, Fructus Forsythiae, Rhizoma Atractylodis Macrocephalae (parched), Semen Plantaginis, Fructus Gardeniae (parched), stir-baked RHIZOMA ANEMARRHENAE, Herba Cirsii, the Radix Paeoniae Alba adds 8 times of decoctings and boils 2 times, the 1st time 2 hours, the 2nd time 1.5 hours, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) the gained dried cream powder is broken, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, the drug regimen of a kind of clearing away heat-damp and promoting diuresis, soothing liver and strengthening spleen is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Bupleuri (processed with vinegar) 100-300 part Herba Hedyotidis Diffusae 100-300 part Herba Artemisiae Scopariae 100-300 part
Cortex Fraxini 100-300 part Radix Isatidis 60-240 part Herba Taraxaci 60-240 part
Rhizoma Alismatis 100-300 part Poria 100-300 part Herba Lysimachiae 60-240 part
Fructus Forsythiae 60-240 part Rhizoma Atractylodis Macrocephalae (parched) 60-240 part Semen Plantaginis 60-240 part
Fructus Gardeniae (parched) 60-240 part stir-baked RHIZOMA ANEMARRHENAE 60-240 part Herba Cirsii 60-240 part
Radix Paeoniae Alba 60-240 part
2, the drug regimen of a kind of clearing away heat-damp and promoting diuresis according to claim 1, soothing liver and strengthening spleen is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
1150 parts of 150 portions of Herba Artemisiae Scopariaes of 150 parts of Herba Hedyotidis Diffusaes of Radix Bupleuri (processed with vinegar)
120 parts of 120 parts of Herba Taraxacis of 150 parts of Radix Isatidis of Cortex Fraxini
120 parts of 150 portions of Herba Lysimachiaes of 150 parts of Poria of Rhizoma Alismatis
120 parts of 120 portions of Semen Plantaginiss of 120 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Fructus Forsythiae
120 parts of 120 portions of Herba Cirsiis of 120 parts of stir-baked RHIZOMA ANEMARRHENAEs of Fructus Gardeniae (parched)
120 parts of the Radix Paeoniae Albas
3, according to the drug regimen of the described a kind of clearing away heat-damp and promoting diuresis of claim 1-2, soothing liver and strengthening spleen, it is characterized in that adopting following method to make:
(1) getting medical materials such as Radix Bupleuri (processed with vinegar), Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae, Cortex Fraxini, Radix Isatidis, Herba Taraxaci, Rhizoma Alismatis, Poria, Herba Lysimachiae, Fructus Forsythiae, Rhizoma Atractylodis Macrocephalae (parched), Semen Plantaginis, Fructus Gardeniae (parched), stir-baked RHIZOMA ANEMARRHENAE, Herba Cirsii, the Radix Paeoniae Alba adds 8-12 times of decocting and boils 2-3 time, the 1st time 2-3 hour, the 2nd time 1.5-2 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) the gained dried cream powder is broken, sieve, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4,, it is characterized in that this Chinese medicine composition is an oral formulations according to the drug regimen of any one described a kind of clearing away heat-damp and promoting diuresis, soothing liver and strengthening spleen among the claim 1-3.
5,, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet according to the drug regimen of the described a kind of clearing away heat-damp and promoting diuresis of claim 3-4, soothing liver and strengthening spleen.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200810105049 CN101264218A (en) | 2008-04-25 | 2008-04-25 | Medicaments assembly for clearing heat and removing dampness, smoothing liver and invigorating spleen and preparation thereof |
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| CN 200810105049 CN101264218A (en) | 2008-04-25 | 2008-04-25 | Medicaments assembly for clearing heat and removing dampness, smoothing liver and invigorating spleen and preparation thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888017A (en) * | 2015-06-18 | 2015-09-09 | 王萧 | Medicine for treating hepatitis B |
| CN105213888A (en) * | 2015-11-09 | 2016-01-06 | 青岛安倍康生物医药技术有限公司 | Spica Prunellae oral liquid of a kind of toxin expelling fat-reducing that dehumidifies and preparation method thereof |
| CN105288315A (en) * | 2015-12-04 | 2016-02-03 | 青岛安倍康生物医药技术有限公司 | Christina loosestrife herb oral liquid for clearing away heat, removing dampness, benefiting bile and expelling toxin and preparation method of christina loosestrife herb oral liquid |
| CN106472730A (en) * | 2015-08-26 | 2017-03-08 | 安徽恋尚你食品有限公司 | A kind of health preserving milk tea possessing clearing away heat-damp and promoting diuresis effect |
-
2008
- 2008-04-25 CN CN 200810105049 patent/CN101264218A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888017A (en) * | 2015-06-18 | 2015-09-09 | 王萧 | Medicine for treating hepatitis B |
| CN106472730A (en) * | 2015-08-26 | 2017-03-08 | 安徽恋尚你食品有限公司 | A kind of health preserving milk tea possessing clearing away heat-damp and promoting diuresis effect |
| CN105213888A (en) * | 2015-11-09 | 2016-01-06 | 青岛安倍康生物医药技术有限公司 | Spica Prunellae oral liquid of a kind of toxin expelling fat-reducing that dehumidifies and preparation method thereof |
| CN105288315A (en) * | 2015-12-04 | 2016-02-03 | 青岛安倍康生物医药技术有限公司 | Christina loosestrife herb oral liquid for clearing away heat, removing dampness, benefiting bile and expelling toxin and preparation method of christina loosestrife herb oral liquid |
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Open date: 20080917 |