CN102764411B - Drug composite for curing jaundice and preparation method thereof - Google Patents
Drug composite for curing jaundice and preparation method thereof Download PDFInfo
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Abstract
The invention provides a drug composite for curing jaundice. The drug composite comprises, by weight, 4 to 6 parts of veronicastrum caulopterum, 8 to 14 parts of virgate wormwood, 6 to 10 parts of linearstripe rabdosia herb, 3 to 5 parts of cape jasmine fruit, 7 to 10 parts of rhubarb, 4 to 6 parts of plantain seeds, 4 to 8 parts of betelnut peel, 4 to 6 parts of ginger peel, 4 to 6 parts of liquorice root, 3 to 7 parts of dried tangerine peel, 5 to 8 parts of pubescent holly root, 5 to 7 parts of herba hyperici japonici, 5 to 7 parts of semen platycladi, 4 to 6 parts of clerodendrumfortunatum and 5 to 8 parts of aloe. The drug composite both cures primary symptoms and cures accompanied symptoms or complications, strengthens body resistance and eliminates evils, treats both principal and secondary aspects of diseases. When the drug composite is applied to curing, the curing effect is rapid and good, and usually gets effects instantly. The drug composite can be used for emergent first-aids, in general outpatients or clinics, drugstores or as household emergency medicine. The drug composite has wide applications, and is a good medicine.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of compositions for the treatment of jaundice medicine and preparation method thereof.
Background technology
Jaundice claims again jaundice, is commonly called as " jaundice ", is a kind ofly to cause the sings and symptoms of skin, mucosa and sclera jaundice because serum mesobilirubin raises.Some hepatopathy, cholecystopathy and hematopathy often can cause the symptom of jaundice.
The fundamental symptoms of jaundice is:
1, the xanthochromia of the tissue such as skin, sclera, when jaundice is deepened, urine, expectorant, tear and perspiration be also by xanthochromia, the general invariant color of saliva.
2, the color change of urine and excrement.
3, symptom of digestive tract, often has abdominal distention, stomachache, inappetence, feels sick, the symptom such as vomiting, diarrhea or constipation.
4, the performance of cholate mass formed by blood stasis, cardinal symptom has: skin pruritus, bradycardia, abdominal distention, fat are let out, nyctalopia, weak, lethargy and headache etc.
The simultaneous phenomenon of jaundice is:
1, the jaundice heat that occurs together sees acute cholangitis, liver abscess, leptospirosis, septicemia, lobar pneumonia.Viral hepatitis or acute haemolysis can first have heating then to occur jaundice.
2, jaundice companion upper abdomen has an intense pain and is found in Biliary Calculi, liver abscess or biliary ascariasis; Abdomen have an intense pain, shiver with cold high heat and jaundice in upper right is charcot triad, prompting acute pyogenic cholangitis.Persistence upper right abdomen dull pain or distending pain are found in chronic cholecystitis, viral hepatitis, liver abscess or primary hepatocarcinoma etc.
3, jaundice companion hepatomegaly, if slightly to moderate swelling, quality soft or medium hardness and smooth surface, see viral hepatitis acute biliary infection or biliary obstruction.Obviously the rough and uneven in surface nodosity of enlargement quality rigid surface sees constitutional or secondary liver cancer.Hepatomegaly is not obvious and quality has lesser tubercle compared with the not whole surface of hard edge that person sees liver cirrhosis.
Modern medicine is for clinical a certain symptom treatment, often fall flat, can not find suitable Therapeutic Method, and the traditional Chinese medical science can be utilized the differential diagnosis of diseases and the dialectical principle combining for the treatment of jaundice, adopt treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical tune, emergency is taken in concurrently, filter out the natural plant that dampness removing jaundice eliminating, heat-clearing and toxic substances removing, removing heat from blood are had one's ideas straightened out, according to theory of Chinese medical science prescription, be prepared from the Chinese medicine composition of the treatment jaundice of provide evident in efficacy, with low cost, toxic and side effects is minimum according to certain weight proportion.
As Chinese invention patent publication number CN102335261A, denomination of invention is: " a kind of pharmaceutical composition for the treatment of jaundice and preparation method thereof " discloses a kind of pharmaceutical preparation for the treatment of jaundice.Be specifically related to a kind of pharmaceutical composition and preparation method of the treatment jaundice of making taking Chinese herbal medicine as raw material.The pharmaceutical composition of described treatment jaundice comprises that the crude drug of following weight proportion is formulated: Herba Artemisiae Scopariae 2-3 part, Herba Lysimachiae 2-3 part, Fructus Gardeniae 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Radix Scutellariae 1-2 part, Poria 1-2 part, Polyporus 1-2 part, Radix Salviae Miltiorrhizae 1-2 part, Radix Paeoniae Rubra 1-3 part.The method of the drug combination preparation of described preparation treatment jaundice comprises the steps: 1) get Herba Artemisiae Scopariae 2-3 part, Herba Lysimachiae 2-3 part, Fructus Gardeniae 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Radix Scutellariae 1-2 part, Poria 1-2 part, Polyporus 1-2 part, Radix Salviae Miltiorrhizae 1-2 part, Radix Paeoniae Rubra 1-3 part; 2) by step 1) thing of getting it filled decocts with water three times, each 1 hour, filters merging filtrate.This kind of medicine can be treated jaundice, but cannot dialectically treat, because jaundice " negative and positive " is divided into two large classes: the YANG jaundice of-retention and fumigation of damp-heat inside the body is separately the YIN jaundice of stagnation of cold-damp; So still there is incomplete place.
Summary of the invention
In order to address the above problem, the invention provides that a kind of quality of the pharmaceutical preparations is stable, determined curative effect, toxic and side effects are low, safe and effective, corresponding treatment partial heat type jaundice, the pharmaceutical composition of wet type jaundice, YIN jaundice (being type of deficiency of both QI and YIN) jaundice partially respectively; It has the resistance of raising, reaches effect of damp eliminating, heat clearing away, jaundice eliminating.
In addition, the present invention also provides the preparation method of this kind of pharmaceutical composition.
For reaching above object technical scheme of the present invention:
Treat a pharmaceutical composition for partial heat type jaundice, pharmaceutical composition of the present invention is to comprise: Herba Veronicastri caulopteri (claiming again: four directions is practiced hard), Herba Artemisiae Scopariae, Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Ilicis Pubescentis, Herba Hyperici Japonici, Semen Platycladi are spent Herba Clerodendri fortunati, Aloe in vain;
The consumption of the each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through inventor, and each component raw material medicine has good curative effect at following weight parts ratio range:
5-7 parts of 4-6 parts of grass before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, east, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts, Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 4-6 parts of Herba Clerodendri fortunati, 5-8 parts of Aloes in vain.
Further, the preferred each component raw material medicine of pharmaceutical composition of the present invention has good curative effect at following weight parts ratio range: before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniae, 8 parts of Radix Et Rhizoma Rhei, east, 7 parts of careless 6 parts, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts, Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain.
A step ground again, the each component raw material medicine of another preferred pharmaceutical composition of the present invention has good curative effect at following weight parts ratio range: careless 4 parts, 8 parts of Pericarpium Arecae, 6 parts of Cortex Zingiberiss, 6 parts, Radix Glycyrrhizae, 6 parts of Pericarpium Citri Reticulataes, 7 parts of Radix Ilicis Pubescentiss, 6 parts of Herba Hyperici Japonici, 6 parts of Semen Platycladi before 4 parts of Herba Veronicastri caulopteris, 14 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 5 parts of Fructus Gardeniae, 7 parts of Radix Et Rhizoma Rhei, east, spend 5 parts of Herba Clerodendri fortunati, 6 parts of Aloes in vain.
Treat a pharmaceutical composition for inclined to one side wet type jaundice, pharmaceutical composition of the present invention is to comprise: Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri, Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis;
The consumption of the each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through inventor, and each component raw material medicine has good curative effect at following weight parts ratio range:
8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, 6-12 points, Poria, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis.
Further, the preferred each component raw material medicine of pharmaceutical composition of the present invention has good curative effect at following weight parts ratio range: 12 parts of Rhizoma Atractylodis, 8 parts of Polyporus, 5 parts of Herba Veronicastri caulopteris, 10 points, Poria, 3 parts of Rhizoma Zingiberiss, 8 parts of Herba Rabdosiae Lophanthoidiss, 7 parts of Cortex Cinnamomis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of Massa Medicata Fermentatas, 4 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Kalimeridis.
One is treated the pharmaceutical composition of YIN jaundice (being called in theory of Chinese medical science: deficiency of both QI and YIN) jaundice, and pharmaceutical composition of the present invention is to comprise: 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts, Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts, mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae;
The consumption of the each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through inventor, and each component raw material medicine has good curative effect at following weight parts ratio range:
12 parts of Radix Codonopsis, 10 parts of Radix Astragali, 8 parts of the Radixs Polygoni Multiflori, 10 parts of the Radix Paeoniae Albas, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 5 parts of Radix Angelicae Sinensis, 5 parts, mountain Cornu Cervi Pantotrichum, 5 parts of Folium Artemisiae Argyis, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Caulis Spatholobis, 12 parts of Rhizomadioscoreae.
Above medicine of the present invention can be made any preparation on pharmaceutics; Preferably make tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, drop pill; The best is made oral liquid, tablet, capsule, granule, drop pill, soft capsule.
The preparation of the effective ingredient of the described present composition and preparation can adopt following methods: one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous circumfluence extraction method, macroreticular resin absorbing method.For example, these crude drug pulverize mix homogeneously can be made to powder takes after mixing it with water; Also can be by these medicines together decocting, then condensed water decocting liquid, makes oral liquid; But in order to make the each crude drug of this medicine bring into play better drug effect, the present invention preferably adopts following technique to extract to raw material, make pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit the scope of the invention.
The weight portion proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight portion proportioning is dosage range provided by the present invention.
The preparation method for the treatment of the oral liquid of partial heat type jaundice drug composition in the present invention, comprises the steps:
A. get 4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts, Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, 5-7 parts of Semen Platycladi before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, east, spend 4-6 parts of Herba Clerodendri fortunati in vain, 5-8 parts of Aloes are for subsequent use;
B. the extraction of extractum I: Herba Veronicastri caulopteri, the Herba Artemisiae Scopariae warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae decocting in water secondary, boil 2 hours with 10-15 times of water gaging for the first time, doubly measures for the second time with 6-12, and decocting in water 2 hours, merges water cooking liquid; Pericarpium Citri Reticulatae decocting in water secondary, boil 2 hours with 6-12 times of water gaging for the first time, boil 2 hours with 3-8 times of water gaging for the second time, merge above-mentioned warm macerating liquid and water cooking liquid, and by the Radix Ilicis Pubescentis warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, within 1 hour, being filtered into 6-10 times of water gaging warm macerating for the second time, merge and be condensed into cream (surveying relative density 1.2-1.3 for 50 DEG C), obtain extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Hyperici Japonici, Semen Platycladi, spend Herba Clerodendri fortunati in vain, Aloe four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopt steam distillation 1～8 hour, collect the another device of volatile oil and preserve, medicinal residues continue to extract; 2. extract: the medicinal residues after the extraction volatile oil such as all the other medical materials and Herba Veronicastri caulopteri, Herba Artemisiae Scopariae medicinal residues and Herba Veronicastri caulopteri decoct with water 1～3 time, decoct 0.5～3 hour at every turn, collecting decoction, filters, and filtrate is concentrated into relative density 1.00～1.35 in the time of 50～80 DEG C, lets cool; 3. precipitate with ethanol: add ethanol to make to reach 10～85% containing alcohol amount, leave standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 DEG C, obtain extractum II;
C. dosing: take extractum I, add water, boiled under stirring 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 DEG C and keep 2～30 minutes, filter; In appropriate polysorbate, add volatile oil, be stirred to mix homogeneously, obtain fragrant solution; Above-mentioned three kinds of medicinal liquids are merged, add water, stir, heated and boiled 5～50 minutes, lets cool, to below 80 DEG C, then by medical filtration;
D. fill, gland, then logical 90～150 DEG C of sterilizings of steam 5～60 minutes, obtain oral liquid.
The preparation method for the treatment of the oral liquid of inclined to one side wet type jaundice in the present invention, comprises the steps:
A '. get 8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, 6-12 points, Poria, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis for subsequent use;
B '. the extraction of extractum I: Rhizoma Atractylodis, Polyporus, the Herba Veronicastri caulopteri warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis decocting in water secondary, boil 2 hours with 10-15 times of water gaging for the first time, doubly measures for the second time with 6-12, and decocting in water 2 hours, merges water cooking liquid; Cortex Cinnamomi decocting in water secondary, boil 2 hours with 6-12 times of water gaging for the first time, boil 2 hours with 3-8 times of water gaging for the second time, merge above-mentioned warm macerating liquid and water cooking liquid, and by the Rhizoma Atractylodis Macrocephalae warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, within 1 hour, being filtered into 6-10 times of water gaging warm macerating for the second time, merge and be condensed into cream (surveying relative density 1.2-1.3 for 50 DEG C), obtain extractum I;
The extraction of extractum II: 1. extract volatile oil: get Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis gomi herbs, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopt steam distillation 1～8 hour, collect the another device of volatile oil and preserve, medicinal residues continue to extract; 2. extract: the medicinal residues after the extraction volatile oil such as all the other medical materials and Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri medicinal residues and Flos Lonicerae decoct with water 1～3 time, each decoction 0.5～3 hour, collecting decoction, filters, filtrate is concentrated into relative density 1.00～1.35 in the time of 50～80 DEG C, lets cool; 3. precipitate with ethanol: add ethanol to make to reach 10～85% containing alcohol amount, leave standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 DEG C, obtain extractum II;
C '. dosing: take extractum I, add water, boiled under stirring 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 DEG C and keep 2～30 minutes, filter; In appropriate polysorbate, add volatile oil, be stirred to mix homogeneously, obtain fragrant solution; Above-mentioned three kinds of medicinal liquids are merged, add water, stir, heated and boiled 5～50 minutes, lets cool, to below 80 DEG C, then by medical filtration;
D '. fill, gland, then logical 90～150 DEG C of sterilizings of steam 5～60 minutes, obtain oral liquid.
The preparation method for the treatment of the oral liquid of YIN jaundice (being called in theory of Chinese medical science: deficiency of both QI and YIN) jaundice drug composition in the present invention, comprises the steps:
A. get 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts, Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts, mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae for subsequent use;
B. the extraction of extractum I: Radix Codonopsis, Radix Astragali, the Radix Polygoni Multiflori, the Radix Paeoniae Alba warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; The Rhizoma Atractylodis Macrocephalae, Poria boil secondary, boil 2 hours for the first time with 10-15 times of water gaging, doubly measure for the second time with 6-12, and decocting in water 2 hours, merges water cooking liquid; Radix Angelicae Sinensis decocting in water secondary, boil 2 hours with 6-12 times of water gaging for the first time, boil 2 hours with 3-8 times of water gaging for the second time, merge above-mentioned warm macerating liquid and water cooking liquid, and by the mountain Cornu Cervi Pantotrichum warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, within 1 hour, being filtered into 6-10 times of water gaging warm macerating for the second time, merge and be condensed into cream (surveying relative density 1.2-1.3 for 50 DEG C), obtain extractum I;
The extraction of extractum II: 1. extract volatile oil: get Folium Artemisiae Argyi, Pericarpium Citri Reticulatae, Caulis Spatholobi, Rhizomadioscoreae four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopt steam distillation 1～8 hour, collect the another device of volatile oil and preserve, medicinal residues continue to extract; 2. extract: the medicinal residues after the extraction volatile oil such as all the other medical materials and Radix Codonopsis, Radix Astragali medicinal residues and mountain Cornu Cervi Pantotrichum decoct with water 1～3 time, decoct 0.5～3 hour at every turn, collecting decoction, filters, and filtrate is concentrated into relative density 1.00～1.35 in the time of 50～80 DEG C, lets cool; 3. precipitate with ethanol: add ethanol to make to reach 10～85% containing alcohol amount, leave standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 DEG C, obtain extractum II;
C. dosing: take extractum I, add water, boiled under stirring 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 DEG C and keep 2～30 minutes, filter; In appropriate polysorbate, add volatile oil, be stirred to mix homogeneously, obtain fragrant solution; Above-mentioned three kinds of medicinal liquids are merged, add water, stir, heated and boiled 5～50 minutes, lets cool, to below 80 DEG C, then by medical filtration;
D. fill, gland, then logical 90～150 DEG C of sterilizings of steam 5～60 minutes, obtain oral liquid.
More than form in the time producing and can increase or reduce according to corresponding ratio, as large-scale production can with kilogram or taking ton as unit, small-scale production also can be in grams, and weight can increase or reduce, but crude drug material weight proportion constant rate between each composition.
Advantage of the present invention and beneficial effect:
Medicine of the present invention adopts not homogeneity, and with different determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, to YANG jaundice treatment, clearing away heat-damp and promoting diuresis is principle, but have domination of damp pathogen and domination of heat point, the domination of heat person that wets, sees heating, thirsty, abdominal distention constipation, oliguria with yellow urine, red tongue, icteric sclera, wiry and frequent pulse; With liver-cleansing yellow-removing soup addition or subtraction of changes, accelerate clearing heat and expelling damp, relieving constipation in conjunction with medical herbs secret recipe, the hot person's disease of domination of damp pathogen is seen, tired nose heave, lazyness is sayed, is stayed and receive, feel sick, the dark micro-Huang of face, and tongue fur is white, moderate pulse, with righting dampness-eliminating soup addition or subtraction of changes, in conjunction with medical herbs proved recipe, reach removing dampness heat clearing away jaundice eliminating object.
The present invention focuses on organic conception, as the disease of seeing liver, do not treat merely hepatitis, be not limited to special side, specially medicine, and execute the method that the heart is made overall plans, situation of change direct or indirect its internal organs meridians is pressed biochemical, inhibition and generation, consider according to the four methods of diagnosis and eight key links comprehensively, join that method is double to be controlled, thereby could internal organs meridians be then the biochemical promotion that becomes from restraint, by badly improving, becoming reason from disorder controls, the hope that just may have, this project therapy dare to be innovated, treating the same disease with different methods, on conventional formulation basis, increase medical herbs secret recipe, to improve resistance, reach damp eliminating, heat clearing away, jaundice eliminating, evident in efficacy.
The present invention had both treated primary symptom, the double disease for the treatment of or complication again, and strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease, is used for the treatment of, and curative effect is faster and better, often can get instant result.Can be used for emergency first-aid, also can be used for general out patient service or clinic, pharmacy or home-use medicine for subsequent use.Being widely used, is really good side's good medicine.
Detailed description of the invention
Treat a pharmaceutical composition for partial heat type jaundice, pharmaceutical composition of the present invention is to comprise: Herba Veronicastri caulopteri (claiming again: four directions is practiced hard), Herba Artemisiae Scopariae, Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Ilicis Pubescentis, Herba Hyperici Japonici, Semen Platycladi are spent Herba Clerodendri fortunati, Aloe in vain;
The consumption of the each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through inventor, and each component raw material medicine has good curative effect at following weight parts ratio range:
5-7 parts of 4-6 parts of grass before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, east, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts, Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 4-6 parts of Herba Clerodendri fortunati, 5-8 parts of Aloes in vain.
The preferred each component raw material medicine of pharmaceutical composition of the present invention has good curative effect at following weight parts ratio range: before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniae, 8 parts of Radix Et Rhizoma Rhei, east, 7 parts of careless 6 parts, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts, Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain.
The each component raw material medicine of another preferred pharmaceutical composition of the present invention has good curative effect at following weight parts ratio range: careless 4 parts, 8 parts of Pericarpium Arecae, 6 parts of Cortex Zingiberiss, 6 parts, Radix Glycyrrhizae, 6 parts of Pericarpium Citri Reticulataes, 7 parts of Radix Ilicis Pubescentiss, 6 parts of Herba Hyperici Japonici, 6 parts of Semen Platycladi before 4 parts of Herba Veronicastri caulopteris, 14 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 5 parts of Fructus Gardeniae, 7 parts of Radix Et Rhizoma Rhei, east, spend 5 parts of Herba Clerodendri fortunati, 6 parts of Aloes in vain.
Treat a pharmaceutical composition for inclined to one side wet type jaundice, pharmaceutical composition of the present invention is to comprise: Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri, Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis;
The consumption of the each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through inventor, and each component raw material medicine has good curative effect at following weight parts ratio range:
8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, 6-12 points, Poria, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis.
Further, the preferred each component raw material medicine of pharmaceutical composition of the present invention has good curative effect at following weight parts ratio range: 12 parts of Rhizoma Atractylodis, 8 parts of Polyporus, 5 parts of Herba Veronicastri caulopteris, 10 points, Poria, 3 parts of Rhizoma Zingiberiss, 8 parts of Herba Rabdosiae Lophanthoidiss, 7 parts of Cortex Cinnamomis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of Massa Medicata Fermentatas, 4 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Kalimeridis.
One is treated the pharmaceutical composition of YIN jaundice (being called in theory of Chinese medical science: deficiency of both QI and YIN) jaundice, and pharmaceutical composition of the present invention is to comprise: 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts, Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts, mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae;
The consumption of the each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through inventor, and each component raw material medicine has good curative effect at following weight parts ratio range:
12 parts of Radix Codonopsis, 10 parts of Radix Astragali, 8 parts of the Radixs Polygoni Multiflori, 10 parts of the Radix Paeoniae Albas, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 5 parts of Radix Angelicae Sinensis, 5 parts, mountain Cornu Cervi Pantotrichum, 5 parts of Folium Artemisiae Argyis, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Caulis Spatholobis, 12 parts of Rhizomadioscoreae.
Medicine of the present invention can be made any preparation on pharmaceutics; Preferably make tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, drop pill; The best is made oral liquid, tablet, capsule, granule, drop pill, soft capsule.
The preparation of the effective ingredient of the described present composition and preparation can adopt following methods: one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous circumfluence extraction method, macroreticular resin absorbing method.For example, these crude drug pulverize mix homogeneously can be made to powder takes after mixing it with water; Also can be by these medicines together decocting, then condensed water decocting liquid, makes oral liquid; But in order to make the each crude drug of this medicine bring into play better drug effect, the present invention preferably adopts following technique to extract to raw material, make pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit the scope of the invention.
The weight portion proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight portion proportioning is dosage range provided by the present invention.
The preparation method of the oral liquid of Chinese medicine composition of the present invention, comprises the steps:
The preparation method for the treatment of the oral liquid of partial heat type jaundice drug composition in the present invention, comprises the steps:
A. get 4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts, Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, 5-7 parts of Semen Platycladi before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, east, spend 4-6 parts of Herba Clerodendri fortunati in vain, 5-8 parts of Aloes are for subsequent use;
B. the extraction of extractum I: Herba Veronicastri caulopteri, the Herba Artemisiae Scopariae warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae decocting in water secondary, boil 2 hours with 10-15 times of water gaging for the first time, doubly measures for the second time with 6-12, and decocting in water 2 hours, merges water cooking liquid; Pericarpium Citri Reticulatae decocting in water secondary, boil 2 hours with 6-12 times of water gaging for the first time, boil 2 hours with 3-8 times of water gaging for the second time, merge above-mentioned warm macerating liquid and water cooking liquid, and by the Radix Ilicis Pubescentis warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, within 1 hour, being filtered into 6-10 times of water gaging warm macerating for the second time, merge and be condensed into cream (surveying relative density 1.2-1.3 for 50 DEG C), obtain extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Hyperici Japonici, Semen Platycladi, spend Herba Clerodendri fortunati in vain, Aloe four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopt steam distillation 1～8 hour, collect the another device of volatile oil and preserve, medicinal residues continue to extract; 2. extract: the medicinal residues after the extraction volatile oil such as all the other medical materials and Herba Veronicastri caulopteri, Herba Artemisiae Scopariae medicinal residues and Herba Veronicastri caulopteri decoct with water 1～3 time, decoct 0.5～3 hour at every turn, collecting decoction, filters, and filtrate is concentrated into relative density 1.00～1.35 in the time of 50～80 DEG C, lets cool; 3. precipitate with ethanol: add ethanol to make to reach 10～85% containing alcohol amount, leave standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 DEG C, obtain extractum II;
C. dosing: take extractum I, add water, boiled under stirring 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 DEG C and keep 2～30 minutes, filter; In appropriate polysorbate, add volatile oil, be stirred to mix homogeneously, obtain fragrant solution; Above-mentioned three kinds of medicinal liquids are merged, add water, stir, heated and boiled 5～50 minutes, lets cool, to below 80 DEG C, then by medical filtration;
D. fill, gland, then logical 90～150 DEG C of sterilizings of steam 5～60 minutes, obtain oral liquid.
The preparation method for the treatment of the oral liquid of inclined to one side wet type jaundice in the present invention, comprises the steps:
A '. get 8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, 6-12 points, Poria, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis for subsequent use;
B '. the extraction of extractum I: Rhizoma Atractylodis, Polyporus, the Herba Veronicastri caulopteri warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis decocting in water secondary, boil 2 hours with 10-15 times of water gaging for the first time, doubly measures for the second time with 6-12, and decocting in water 2 hours, merges water cooking liquid; Cortex Cinnamomi decocting in water secondary, boil 2 hours with 6-12 times of water gaging for the first time, boil 2 hours with 3-8 times of water gaging for the second time, merge above-mentioned warm macerating liquid and water cooking liquid, and by the Rhizoma Atractylodis Macrocephalae warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, within 1 hour, being filtered into 6-10 times of water gaging warm macerating for the second time, merge and be condensed into cream (surveying relative density 1.2-1.3 for 50 DEG C), obtain extractum I;
The extraction of extractum II: 1. extract volatile oil: get Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis gomi herbs, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopt steam distillation 1～8 hour, collect the another device of volatile oil and preserve, medicinal residues continue to extract; 2. extract: the medicinal residues after the extraction volatile oil such as all the other medical materials and Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri medicinal residues and Flos Lonicerae decoct with water 1～3 time, each decoction 0.5～3 hour, collecting decoction, filters, filtrate is concentrated into relative density 1.00～1.35 in the time of 50～80 DEG C, lets cool; 3. precipitate with ethanol: add ethanol to make to reach 10～85% containing alcohol amount, leave standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 DEG C, obtain extractum II;
C '. dosing: take extractum I, add water, boiled under stirring 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 DEG C and keep 2～30 minutes, filter; In appropriate polysorbate, add volatile oil, be stirred to mix homogeneously, obtain fragrant solution; Above-mentioned three kinds of medicinal liquids are merged, add water, stir, heated and boiled 5～50 minutes, lets cool, to below 80 DEG C, then by medical filtration;
D '. fill, gland, then logical 90～150 DEG C of sterilizings of steam 5～60 minutes, obtain oral liquid.
The preparation method for the treatment of the oral liquid of YIN jaundice (being called in theory of Chinese medical science: deficiency of both QI and YIN) jaundice drug composition in the present invention, comprises the steps:
A. get 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts, Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts, mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae for subsequent use;
B. the extraction of extractum I: Radix Codonopsis, Radix Astragali, the Radix Polygoni Multiflori, the Radix Paeoniae Alba warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merges infusion for the second time; The Rhizoma Atractylodis Macrocephalae, Poria boil secondary, boil 2 hours for the first time with 10-15 times of water gaging, doubly measure for the second time with 6-12, and decocting in water 2 hours, merges water cooking liquid; Radix Angelicae Sinensis decocting in water secondary, boil 2 hours with 6-12 times of water gaging for the first time, boil 2 hours with 3-8 times of water gaging for the second time, merge above-mentioned warm macerating liquid and water cooking liquid, and by the mountain Cornu Cervi Pantotrichum warm macerating secondary that adds water, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, within 1 hour, being filtered into 6-10 times of water gaging warm macerating for the second time, merge and be condensed into cream (surveying relative density 1.2-1.3 for 50 DEG C), obtain extractum I;
The extraction of extractum II: 1. extract volatile oil: get Folium Artemisiae Argyi, Pericarpium Citri Reticulatae, Caulis Spatholobi, Rhizomadioscoreae four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopt steam distillation 1～8 hour, collect the another device of volatile oil and preserve, medicinal residues continue to extract; 2. extract: the medicinal residues after the extraction volatile oil such as all the other medical materials and Radix Codonopsis, Radix Astragali medicinal residues and mountain Cornu Cervi Pantotrichum decoct with water 1～3 time, decoct 0.5～3 hour at every turn, collecting decoction, filters, and filtrate is concentrated into relative density 1.00～1.35 in the time of 50～80 DEG C, lets cool; 3. precipitate with ethanol: add ethanol to make to reach 10～85% containing alcohol amount, leave standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 DEG C, obtain extractum II;
C. dosing: take extractum I, add water, boiled under stirring 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 DEG C and keep 2～30 minutes, filter; In appropriate polysorbate, add volatile oil, be stirred to mix homogeneously, obtain fragrant solution; Above-mentioned three kinds of medicinal liquids are merged, add water, stir, heated and boiled 5～50 minutes, lets cool, to below 80 DEG C, then by medical filtration;
D. fill, gland, then logical 90～150 DEG C of sterilizings of steam 5～60 minutes, obtain oral liquid.
More than form in the time producing and can increase or reduce according to corresponding ratio, as large-scale production can with kilogram or taking ton as unit, small-scale production also can be in grams, and weight can increase or reduce, but crude drug material weight proportion constant rate between each composition.
Certainly, the pharmaceutical composition for the treatment of jaundice of the present invention also can adopt traditional method: the medicine of above composition is placed in clean marmite, adds clean drinking water, submergence medicine 3-5 centimetre, soak after 15-20 minute, slow fire heating changes intense fire after 3-5 minute and boils.From the timing of when boiling and use slow fire instead and continue to boil 45 minutes to one hour, during this time as moisture can add boiling water not, after the time arrives, filter and remove residue, acquisition medicinal liquid, natural cooling.
Weight portion in this detailed description of the invention is all adopted as metric unit: gram.
The drug combination preparation for the treatment of jaundice of the present invention, in the time being prepared into medicament, can add the acceptable adjuvant of medicine, described pharmaceutically acceptable adjuvant, comprise diluent conventional in preparation, filler is (as mannitol, lactose, Polyethylene Glycol), binding agent (starch, microcrystalline Cellulose), disintegrating agent is (as carboxymethyl cellulose, the hydroxypropyl cellulose of low replacement), lubricant is (as Pulvis Talci, magnesium stearate), wetting agent is (as propylene glycol, ethanol), stabilizing agent (EDTA-2Na, sodium thiosulfate, sodium pyrosulfite, sodium sulfite, ethanolamine, sodium bicarbonate, nicotiamide) etc.Above-mentioned adjuvant can be common dose, mixes with Principle component extraction thing with the proportioning of commonly using, and when after Principle component extraction thing Determination of quantity, the proportioning between each pharmaceutic adjuvant can suitably regulate as required.
The pharmacodynamics Analysis on TCM prescriptions of pharmaceutical composition and the clinical efficacy experiment for the treatment of jaundice by the present invention below, further illustrate good effect of the present invention.
Wherein, the drug regimen object space solution for the treatment of partial heat type jaundice:
Herba Veronicastri caulopteri, Herba Artemisiae Scopariae, Herba Rabdosiae Lophanthoidis; Effect of the damp eliminating of Fructus Gardeniae energy, heat clearing away, removing toxic substances, jaundice eliminating is monarch, and Radix Et Rhizoma Rhei, Radix Ilicis Pubescentis, Herba Hyperici Japonici, Semen Platycladi, Aloe etc. have dampness, heat clearing away, removing heat from blood, toxin expelling, make damp and hotly to discharge from stool: Dong Qiancao,
Pericarpium Arecae, Cortex Zingiberis, spend Herba Clerodendri fortunati in vain and there is liver heat removing, toxin expelling, circulation of qi promoting, diuretic, solution steam, dirty long-pending toxin is discharged from urine, Radix Glycyrrhizae has priming and clears the way focus for making it effect: above yellow cellulitis YANG jaundice partial heat type scientific formula energy clearing heat and expelling damp, removing toxic substances,
Resolving functions, to reach liver heat removing, eliminating pathogen in the liver, damp eliminating heat, toxin expelling, quick damp eliminating heat, makes two just can lead to, soothing the liver recovery liver function, yellow cellulitis Lock-out, recovery from illness, 886 routine patient's cure rates 9 2.6%, though all the other patients do not fully recover, disease takes a turn for the better gradually, alleviates until fully recover.
Treat the drug regimen object space solution of inclined to one side wet type jaundice: energy damp eliminating heat clearing away toxin expelling jaundice eliminating is practiced hard in Herba Rabdosiae Lophanthoidis, Rhizoma Atractylodis, Polyporus, four directions; Poria, Rhizoma Zingiberis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Astragali, can be pungent wetly activate yang, hold up the moon, help gasification, invigorating primordial QI, invigorate blood circulation, tune reaches the adjuvant drug of liver spleen organ, Herba Kalimeridis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, theory of Chinese medical science are shown in disease, the knowing the liver disease will be transmitted into the spleen of liver, tonifying the spleen impels liver equilibrium between yin and yang in the ban, add Radix Glycyrrhizae for making priming reach focus, disease must be removed. get well.
The drug regimen object space solution for the treatment of YIN jaundice (being called in theory of Chinese medical science: deficiency of both QI and YIN) jaundice:
In the QI invigorating benefits such as Radix Codonopsis, Radix Astragali, Folium Artemisiae Argyi, Rhizomadioscoreae, spleen invigorating is monarch: the Radix Polygoni Multiflori, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Radix Angelicae Sinensis, can be to consolidate the nourishing liver-YIN of getting rid of evils as minister, and Poria, Pericarpium Citri Reticulatae, mountain Cornu Cervi Pantotrichum etc. are assistant, and with damp eliminating circulation of qi promoting, gas is capable, and blood is gone, and changes
Kind blood circulation, makes equilibrium between yin and yang, and sun is raw cloudy long, and the long fire of sun dissipates from diving, and sick naturally good, this therapy truly has unique distinction, spends few, and curative effect is high, short treating period, and especially medical herbs is welcome by patient deeply.
The all medicines of the present invention, the dosage 1-3 gram of every taste medicine is applicable to 1-3 year child, but Semen Armeniacae Amarum is slightly poisonous, 1-3 year child should not with or be cautious use of, as used, please application under doctor instructs.Clear thinking of the present invention, compatibility is tightly accurate, and any Herba indigoferae Pseudotinctoriae all can not lack, and lacking simply curative effect will have a greatly reduced quality.
Typical case's case history:
Case 1.
Chen, man, 47 years old, patient's calling, disease is seen, heating is thirsty, icteric sclera, all skin turning yellow, oliguria is helvolus, stool, abdominal distention, tongue fur is red, wiry and frequent pulse, liver helps down, 2CM, spleen.Body temperature 39.2.C, liver function: icteric index 18u, pyruvic transaminase 98u, Lu Geer iodine test solely test 16 u is in hospital because of seriously ill.
Dialectical: YANG jaundice, partial heat type.
The rule for the treatment of: liver heat removing gallbladder damp eliminating heat, Huang disappears;
The pharmaceutical composition for the treatment of jaundice using is: 6 parts of grass, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts, Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, 7 parts of Semen Platycladi before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniae, 8 parts of Radix Et Rhizoma Rhei, east, spend 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain.
Three doses, decoction, every day twice, sooner or later respectively once, cool clothes.
Curative effect: use this pharmaceutical composition, every day 3 times, each 20, taking medicine after meal, first course for the treatment of, its disease is taken a turn for the better, and takes second course for the treatment of with disease, and patient's heat is moved back, and Huang moves back, and appetite is slightly good.Through the 3rd course for the treatment of, in high spirits, each disease disappears, and it is normal that liver function test recovers, icteric index 4u, and 7u is solely tested in Lu Geer iodine test () brain wadding test (), and the More that fullys recover from an illness leaves hospital.
Case 2.
Zhang, man, 52 years old, it is medical that patient comes institute: disease is seen lack of appetite, uncomfortable in chest, uncomfortable under both sides of the chest, tired, sometimes half congealed wet when stool, yellowish or reddish urine, the micro-Huang of order and the whole body, thick fur is greasy, stringy and rolling pulse, 2.5cm under liver rib, spleen (+), body temperature 38.4.C, liver function icteric index 21u, Lu Geer iodine test, the turbid test of Moschus moschiferous 15u, brain wadding (+++), transaminase 86u, card is shown in.
Diagnosis: the inclined to one side wet type of YANG jaundice,
Rule: dampness removing, heat clearing away, jaundice eliminating,
The pharmaceutical composition of the treatment jaundice using is: 12 parts of Rhizoma Atractylodis, 8 parts of Polyporus, 5 parts of Herba Veronicastri caulopteris, 10 points, Poria, 3 parts of Rhizoma Zingiberiss, 8 parts of Herba Rabdosiae Lophanthoidiss, 7 parts of Cortex Cinnamomis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of Massa Medicata Fermentatas, 4 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Kalimeridis.
Three doses, decoction, every day potion, sooner or later respectively once, cool clothes;
After the preferred embodiment describing in detail, being familiar with this technology personage can be well understood to, can carry out various variations and amendment not departing under above-mentioned claim and spirit, any simple modification, equivalent variations and modification that all foundations technical spirit of the present invention is done above embodiment, all belong to the scope of technical solution of the present invention.And the present invention is not also limited to the embodiment of example in description.
Claims (3)
1. treat the pharmaceutical composition of jaundice for one kind, it is characterized in that, it is to be made up of the crude drug of following weight portion proportioning: 4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts, Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, 5-7 parts of Semen Platycladi before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniaes, 7-10 parts of Radix Et Rhizoma Rhei, east, spend 4-6 parts of Herba Clerodendri fortunati, 5-8 parts of Aloes in vain.
2. treat as claimed in claim 1 the pharmaceutical composition of jaundice, it is characterized in that, it is to be made up of the crude drug of following weight portion proportioning: 6 parts of grass, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts, Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, 7 parts of Semen Platycladi before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniaes, 8 parts of Radix Et Rhizoma Rhei, east, spend 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain.
3. treat as claimed in claim 1 the pharmaceutical composition of jaundice, it is characterized in that, it is to be made up of the crude drug of following weight portion proportioning: 4 parts of grass, 8 parts of Pericarpium Arecae, 6 parts of Cortex Zingiberiss, 6 parts, Radix Glycyrrhizae, 6 parts of Pericarpium Citri Reticulataes, 7 parts of Radix Ilicis Pubescentiss, 6 parts of Herba Hyperici Japonici, 6 parts of Semen Platycladi before 4 parts of Herba Veronicastri caulopteris, 14 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 5 parts of Fructus Gardeniaes, 7 parts of Radix Et Rhizoma Rhei, east, spend 5 parts of Herba Clerodendri fortunati, 6 parts of Aloes in vain.
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| CN201210285751.3A CN102764411B (en) | 2012-07-13 | 2012-08-13 | Drug composite for curing jaundice and preparation method thereof |
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| CN201210242546.9 | 2012-07-13 | ||
| CN201210285751.3A CN102764411B (en) | 2012-07-13 | 2012-08-13 | Drug composite for curing jaundice and preparation method thereof |
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| CN102764411B true CN102764411B (en) | 2014-08-20 |
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| CN104189579B (en) * | 2014-08-28 | 2017-11-21 | 邓鑫 | A kind of Chinese medicine composition for treating liver cancer jaundice |
| CN105012370A (en) * | 2015-07-03 | 2015-11-04 | 刘明璇 | Medicine for treating infant jaundice |
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